depression
"Used to be somewhat effective (hence it even getting a 3) but now is about as effective as placebo at best. The only things keeping me stable right now are Seroquel XR, Wellbutrin XL, and a lot of caffeine. I'm still trying to even get an appointment scheduled with my psychiatrist so I can get off of this useless drug and on to something that might actually work, and it's probably not going to be an SSRI, since I've taken several of them before and none of them have worked except Paxil, but that gave me too many side effects."