major depressive disorde
"I have been on Wellbutrin for a year and a half. If you do not respond to SSRIs (like me) I would definitely recommend giving Wellbutrin/Bupropion a go. At the end of the fourth week on 150mg, just before I was about to tell my doctor it was another dud - I very suddenly felt clear and not like a slug human. I would say it's such a strong feeling that you will know if it works and the day it starts. I had a horrible time falling asleep, lost my appetite, but  felt super ecstatic! Maybe it's because for the first time in 8 years (I am 26) I felt what it's like to not see doing the most simplest of tasks as a stressful chore. I could have cried! I've lost a bit over ten pounds since being on it. Currently I am on the highest dose which is 600"