depression
"I have been on 200mg of buproprion xl for about 2 years and I can say that it has had a great effect on my life.  First off, I quit smoking.  The urge to smoke was like, GONE!  My mood was great for about 1 1/2 yrs and I feel that this is a great medicine for most.  I did gain weight on it and my appetite has actually INCREASED, so I guess I am one of the unlucky ones.  I have noticed some withdrawal symptoms if I miss a dose, which is something else to consider.  It has stopped being effective for me and I am concerned about raising my dosage due to the withdrawal symptoms I have experienced.  I am constantly tired and lethargic and recently had a major depressive episode. "