abnormal uterine bleeding
"I gained a few pounds on the Depo shot but that wasn't too bad. Was on it for 2 years. The first 1 1/2 years were great, although I had a decreased sex drive and the shots left my arm sore for days. Had about 1 week long period just before getting the next shot, so about every 3 months. Bled almost constantly the last 6 months."