gout
"Been taking Febuxostat for 20 months or so. Prior to doing so I had major agony gout attacks every two weeks. First year the tablets activated all the stored crystals and I was in agony, but not as frequent...anyway I stuck with it and have had 2 minor not too painful attacks in the last 8 months...after 2 yrs I should have cleared all the joints and won't have any further attacks. I'm running and in the gym for the first time in nearly 3 years, so feel better all round. Stick with it, is my advice. The only downside has been a reduction in libido, but I'll take that over the agony of gout."