restless legs syndrome
"I started on pramipexole hydrochloride 6 years ago and at first suffered from jerking all the time. My head would always jerk to the left, my shoulders would jerk up and down and my legs shook all the time if I stood still or sat down. The recommended dosage didn't have any effect on the RLS at all and slowly the dose was raised. The jerking subsided after a few weeks and I was able to lead a happy life until a couple of months ago when it stopped working. It was wonderful for 6 years then over about a month it stopped having any effect whatsoever."