depression
"For anyone taking this or planning on taking this, DO NOT DISCONTINUE WITHOUT WEANING OFF!  

That said, besides brain zap, yawning and anorgasmia over the first 3 months of treatment (18 months and counting ), Cymbalta has been a great treatment for my anxiety / depression issues. I have only experienced these side effects when changing dose or missing a dose (30mg a day, last 15 months, 60mg a day for first 3). At one point I wanted to come off it, GP guided me through a 12 week taper off course, but my 2-5 drinks a month were causing the problems I had associated with the medicine. I no longer drink, and it's all so cruisy.

I take mine 1-2 hours before 'bed time'. Works for me because I tend to sleep deeper and wake with lots of energy."