depression
"I experienced only adverse reactions to SSRIs and TCAs thanks in part to being bipolar, but Tramadol has been a God send for my depression. I was sick and tired, literally, of trying different medicines only to have my mood get thrown around crazily. Tramadol worked when nothing else could touch the depression. I take it twice daily. Could not live without it. I am so thankful that my psychiatrist is open to new ideas and tried this, I only will encourage others to try this also. Because of the Tramadol I am now recovered from any form of self injury - I am free for over 3 years.  It works. Simple."