narcolepsy
"I was given Xyrem two months ago to help with narcolepsy with cataplexy along with fibromyalgia.  I had an expectation based on what I was told it would do that I would instantly be falling asleep.  It didn't happen.  Minimal effects.  My neurologist started me on 2.25mg x 2 at night.  When we discussed the situation on my next visit and I talked with the Xyrem nurse, this was common on this dosage.  He increased it to 3.0 for the next six weeks.  I am now seeing some results in sleep, cataplexy and narcolepsy.  He did tell me that he increases to maximum dosage at much slower rates than any doctors to lessen the side effects.  To date all I have had was a slight headache several days which might or might not be related.  So far so good!"