major depressive disorde
"Having failed most SSRI's Remeron was a real surprise. It calmed me, helped me sleep, helped me focus but most importantly had almost no side effects. My appetite went crazy the first week but mellowed out afterwards. I get pretty drowsy about an hour after taking it, so I only take it at bedtime. I had to drop from 45 mg to 30 mg due to it amping me up rather than sedating. Works fine, no tolerance type effects unlike Z-drugs."