rheumatoid arthritis
"I am 3 weeks into my second dose of Simponi. Was on Enbrel for 4 1/2 yrs. with good results then it stopped working.  the numerous side effects following my first dose came close to keeping me from trying a second month. this month i have had diarrhea for 3 weeks but that's an improvement over last month.  joint pain, stiffness are better; but no effect on fatigue so far.  It takes 6-8 weeks to know for sure how it will work.  It is not possible to see results in hours or days. I have decided to try one more month since  my next step is infusion mediciness."