pain
"I went through the myriad of short acting oral analgesics, and just couldn't stand the constant ups and downs, and always felt like I was only comfortable for half of the life of the pill. I asked my doctor to take me off OxyContin (40 mg.), he offered Duragesic as an alternative. 

I use 100 mcg every 3 days with no problem.  Side effects are constipation, and short term memory loss. I'll happily trade that for effective pain relief. A huge plus is not developing a tolerance for it, so I don't have to have it constantly increased over the years. I don't use "breakthrough" meds, but I use Lyrica (about 6 years now) to help with pain from nerve damage. The combination works great for me."