osteoarthritis
"I have 5 lumbar  5 cervical bulging discs =  left sciatic, left hip pain, bilateral wrist to above elbow pain.  The pain is severe.   Per MD orders,  I took Duexis 7 days on/7 days off for two cycles.  When I stop,  within 3-4 days pain makes my life dysfunctional.  Within 2 days of starting, the pain decreases significantly.   The drug is extremely expensive so MD ordered 800 mg tablets ibuprofen and I bought over the counter 10 mg famotadine tabs.  I have been taking that duo twice a day and the Duexis once a day.  I am very reluctant to take this med long term because of  my age (70 ), IBS, and possible  liver/kidney problems.  However, it is the ONLY regime right now that relieves the pain."