anxiety
"My doctor prescribed this for my anxiety due to perimenopause, 37 mg.  I was always tired on it so he increased it to 75mg xr.  I'm not as tired as I used to be and I no longer wake with anxiety and can sleep through the night.  My energy level is not as high as it used to be before Effexor.  My appetite has also increased.  I've heard this can be due to a combination of the Effexor and menopause.  If I skip a dose, I get headaches."