irritable bowel syndrome
"I'm 65, have suffered from Irritable Bowel Syndrome-Constipation my entire adult life.  Have taken 145 mcg dose of Linzess off and on since the middle of August 2013.  The longest stretch I have taken it for is 12 days.  I was also taking Align, but discontinued it during the 12-day Linzess experiment so I could evaluate the Linzess objectively, and got horrible trapped gas and splenic flexure syndrome for my troubles.  I resumed the Align, which has been a blessing, and now do Linzess every second or third day.  The Linzess is a very effective laxative, although it will give you at least one or two bouts of diarrhea every time.  But without the Align it seems to aggravate the abdominal pain and bloating, NOT alleviate it.  Align is more effective for gut pain."