depression
"The first time I took Zoloft, it was a life-saver, it dragged me out of a deep depression and alleviated most of my anxiety, allowing me to get out of the house and get a job and live a normal life, with no REAL noticeable side-effects, (at higher doses it became difficult to orgasm, but I just didn't take as much and I was fine) 12 years later I tried it again, after falling back into severe depression, anxiety and agoraphobia. It did help, but this time not nearly as much. It lifted my mood and helped me have less mood swings. It barely touched my anxiety and agoraphobia, plus this time around the sexual side effects were devastating. The effort it took to have an orgasm was unbelievable! Even at a dose of only 50mg."