narcolepsy
"I have had narcolepsy since at least age 15 but was not diagnosed until around age 27.  I started with 200mg of Provigil, then when that didn't work 400mg Provigil.  That didn't work so we tried 200mg Provigil with 15mg Adderall. That helped some for a while.  Then when adderall was affecting my blood pressure we moved to Nuvigil and away from the combination. I have been on 250 Nuvigil for about 2 yrs.  It has done well but now within recent weeks, it is not holding it's own.  I just wonder, at this point what hope is there? If Provigil and Nuvigil do not work, how can I continue working? I can't drive like this, I can't focus, I can't stay awake."