depression
"I'm at 225mg.

There may, or there may not, be leg side effects. It can create -- or increase -- muscle rigidity. A massage will painful to the point of bliss -- the pain feels soooo good.

But, if you start to get spasms WHEN YOU LIE DOWN they will be a whole different kind of pain! So strong they have now torn two tendens in my left leg the last 2 years. Effexor?

In hospital they gave me my dose in the early morning and I had no spasms at night. But they also gave me morphine, oxy, and valium. NICE!!!

At home, night dose > night spasms!  Dose in afternoon > very few spasms. Love to hear from others!"