osteoarthritis
"My doctor recommended Euflexxa in a severely arthritic left knee after 18 months of cortisone shots.  The cortisone worked very well but there were concerns about using it "long term".   I had the 3 rounds of shots, with the last round 5 weeks ago.  I have more pain now than before the shots.  I am woken more at night with pain, and have more constant pain throughout the day.  The only benefit from the Euflexxa is a mild increased tolerance for kneeling."