irritable bowel syndrome
"I can't believe my insurance agreed to cover this! It's $10 per pill otherwise.  
The 145mcg is a high enough dosage. 290mcg and your system will go nuts. 
This medicine works great and usually within 12 hours.  Take it at the night, not in the morning like the instructions say.   Make sure you have the day off.  Best way to take it, have a light dinner, wait one hour, have dessert.  In one hour you will have bloating, cramps and gas. The cramps and bloating are normal. It means your system is moving. By the next morning (maybe sooner) the bowel movements will start.  
DO NOT TAKE THIS EVERYDAY!  Your body will build an immunity if you do.  Keep hydrated as you will lose quite a bit of water."