depression
"I have had recurrent depression for over 35 years, tried loads of different antidepressants over that time. Never fully recovered from last bout 2 years ago, and became sensitive to four different drugs since then. 
At last saw a consultant psychiatrist who prescribed Mirtazapine on top of the 60mg duloxetine I was already on. In 2 days I feel better than I have for several years, so much energy and return of old concentration skills. I am on 15mg, then will up to 30mg in 2 weeks, and 45mg if need be. 
Yes, I am very sleepy, and yes the dreams are mind blowing if the only downside is I gain weight I can live with that. I would rather have my brain back functioning as it ought to and enjoy my life. For me, this has been a miracle so far!"