chronic pain
"All I have to say is, give them a bit of time to work. Especially if you were on high doses of another opiate. Your body will not even feel them for the first 4 or 5 days. I was taking 3x40mgs of methadone along with 6x15mgs of oxycodone per day for 4 years until I had a heart attack. My dr. sent me for an EKG and my "QT" interval was in the 500s along with leg and body swelling, tightness in the chest along with severe constipation (most likely from methadone). Once they got me weaned down of the methadone they prescribed 2x16mg Exalgo per day keeping the oxycodone as breakthrough. I started taking them as directed with no relief and I felt nauseous with afternoon headaches. At the 4th day I started feeling more relief. Give me time."