major depressive disorde
"I have an extreme case of depression that very few experience, and I have had extreme depression for over 25 years with pain I cannot begin to describe. In the past, Nefazodone and Cymbalta rescued me and each worked for a decade or more, but they eventually pooped out.  None of the SSRIs and other drugs worked for me.  I switched from Cymbalta to this drug and within days this drug started working.  If you are one of the 10% of depressed people where only norepinephrine antidepressants work for your depressed (SNRIs, Tricyclics) then this is a good drug to try. It is too early to tell if this drug will work long term for me.  The side effects of this drug went away within a week for me."