depression
"Desipramine has worked wonders for me. After many years on and off of various medications that would - at best, if they worked at all - help briefly and degenerate into vicious side effects, this one worked like a charm. The only down-side is that it is so innocuous that it's easy to get used to the improvement; since the improvements it can be tempting to consider oneself "better" and discontinue prematurely. Fortunately there are no discontinuation effects, and the only side effect I have experienced is slight photosensitivity."