psoriasis
"Entire palms of my hands and fingertips in the exact same locations become afflicted with hard skin then cracks making it very painful & extremely difficult for work and do normal activities. Prescribed  Betamethasone Valerate 0.1% & had no effect, appeared to make the condition worse.  Dermatologist took skin graph with positive test results for psoriasis.  I was then Prescribed Topicort and used it twice a day, once in the morning & once at night for two weeks. What a relief !  My skin cleared up completely !  No cracks, No peeling skin, No redness & my hands actually feel pliable again.  This lasts for maybe 3 weeks and I will begin to get hardening of palms and finger tips again and have to complete another two week cycle of Topicort."