hiv infection
"I have been on the combination of Truvada/Prezista/Norvir for over 2 years now.  The side effects that cause me the most problems are the ones dealing with my kidneys!  The Truvada has made my GFR go down to 30, very close to changing medicines at that point. But it has been working so well that we took a very close monitoring of my kidney function, and my GFR has stabilized around 55.  Other than that the side effects have been minimal to none.  Great medicine overall!"