migraine prevention
"I found that topiramate was reasonably effective in preventing my migraines, however it completely rid me of any and all appetite.  Within the first week I lost about 7 lbs, and within 3 weeks I had lost a total of 20 lbs.  I'm not a big guy (5'6", 160 lbs) so it was a very significant weight loss.  I became very weak and became ill from fatigue due to no appetite and weight loss.  It did lessen my migraines, however I still had them about once a week or so.  The weight loss, fatigue and overall effectiveness of the medication caused me to discontinue its usage."