endometriosis
"My doctor put my on Depo-Provera after laproscopy for endometriosis.  I had irregular periods after the first shot and after the second I remember I had one period that seemed to last for a month. This is a known side effect and as promised it went away after the third shot.  I haven't had my period now in about a year.  I also haven't had any debilitating endometriosis symptoms either.  I think I gained about 5 lbs total but then again I'm also in my 40s and that could simply be a part of aging. I am a big fan.  It gave me nearly total relief after getting through the first 6 months."