rheumatoid arthritis
"When all other meds/combo of meds failed my rheumy put me on mtx (8 tabs@ 2.5 mg. once a week).   I still take 4 mg prednisone twice a day, 400 mg of plaquenil at night, and folic acid every morning.  It's been a long road and a lot of ups and downs but I have seen the most progress since mtx was added to my combo of meds.   I still have some pain but the stiffness (which used to last most of the day) and the swelling has improved.  I am always nauseous and feel lethargic the first 24 - 48 hours after the mtx dose but 1-2 days of that is better than the alternative.   I've always been extremely active so it has been rough struggling to do simple things."