high blood pressure
"Everyone's physiology reacts uniquely.  Calcium channel blockers cause my ankles to swell.  One beta blocker didn't work; another worked for 10 years before stopping.  Alpha blockers gave me orthostatic hypotension.  The perfect combination seemed to be an ace inhibitor and a diuretic, but the diuretic gives me dangerously high uric acid. It lowers fluid volume and decreases the kidney's ability to excrete uric acid. Losartan is the only BP medication that lowers uric acid, so I was switched to losartan with a small dose of HCTZ.  Working well so far."