diabetes, type 2
"After 10 years on metformin XR, my blood sugars began to creep up.  My A1c was now in the mid-7's.  Doctor kept me on my 4 tabs of 500 mg each of metformin XR - which I take four times per day, about every 8 hours.  He added 1-2mg tablet of glimepiride, 1/2 at breakfast, and half at dinner.  The lows about 2 hours after taking the breakfast dose were immediately a problem.  I then switched to a 1/4 tab (cutting that tab into 4 parts is a skill in itself), four times per day, and the lows became minimal. And my A1c is back to 6.4.  I see that it is recommended to take at breakfast, but my doctor has allowed me to adjust my medications.  It has been better that I control the times."