ibromyalgia
"2017 marks my 21st year on Ultram.  Initially it was prescribed for migraines. I was later diagnosed with fibromyalgia, and continued on Ultram, as it eased the stiffness and difficulty of movement.  Soon enough I needed more than prescribed.  My doctor  took it away for 8 horrific months.  Withdrawal never let up. Weakness, crying, vomiting, MDD.  I used those 8 months for research, eventually coming up with proof that Ultram was the drug of choice for FMS. My doctor gave it back in a lower dose, and a different medication to control withdrawal. Next step was bloodwork in a genetics lab. I metabolize Ultram 4x faster than average. Now I'm over 50, using Ultram as a mood stabilizer.  It can be psychologically addictive;  caveat emptor!"