depression
"Started at 150 mg, took half a day and felt like a new person - it changed my life.  Quickly found I need to take the full tablet to get the same effect.  Three months ago doctor increased to 250 mg, take full tablet but the effect only lasts 3-4 hours.  Your body becomes immune and needs more and more.  And now I "crash" early afternoon and become very  depressed.  Took appetite away, lost 20 lbs in little over a year."