rheumatoid arthritis
"A couple of years ago my husband was at the point where he was limping severely, with swollen joints in his hands and feet. He was diagnosed with rheumatoid arthritis and began taking methotrexate at 20 mg once a week; he has since cut back to 17.5 mg. It has made a huge difference in his functioning, and he's pretty much back to normal. (Regular strength training at the YMCA has also helped a lot). He was also told to take folic acid once a day, which he does. The only negative is that his hair has thinned quite a bit, which is a common side effect. He is in his 70s."