endometriosis
"I've been on Lupron for 8 months now. I have very very painful endo that has put me in the ER at least 50X in the last 5 years. I tried depo shot and continuous use of the Nuva ring before this. Nothing has worked, except Lupron. 
I do suffer hot flashes and a bit of fatigue/joint point around the time that would be my cycle. The first cycle on the injection was still hell, second I could still work :)! My doctor wants me on it for a while, as I'm only 23 and she does want to jump to a hysterectomy just yet. 
I'm scared to go beyond the recommended year of Lupron, but so far so good and it's the only thing that's given my life back. I hope that if you try it, it works for you. Though, we are all different."