restless legs syndrome
"I have had restless legs syndrome for over a decade varying from mild, moderate to quite severe at times. After being prescribed Prozac I found that it helped the depression but made the restless legs syndrome worse.  After falling and cracking my ribs I was prescribed 100mg Tramadol twice daily. It was excellent for pain relief, RLS completely disappeared and I got a good night's sleep. I stopped the Tramadol after 2 weeks and experienced flu like withdrawal symptoms and RLS returned with a vengeance. Internet info is that Prozac can affect restless legs syndrome and taken with Tramadol can cause serotonin syndrome. I contacted doctor and requested lower dose Tramadol to wean myself off. I am still taking  one 50mg at 4pm, any later and the RLS kicks in and is harder to control."