constipation, chronic
"I've had chronic constipation for as long as I can remember.  Tried eating more fiber and drinking more water and that just makes things worse.  Prescribed the 145 and took it in the morning.  Nothing for the first 4 days then remembered my doc said that some of her patients had better luck taking it at night.  It worked great then.  Some times I have  diarrhea but not always.  The only downside is unpredictability.  I will take this over constipation any day.  Other then diarrhea, I have no side affects.  So give it a try at night if you aren't having luck in the morning."