psoriatic arthritis
"Otezla had recently been approved. After three months on Otezla my skin was mostly clear (psoriasis returned FAST post-Embrel). I was able to stop ibuprofen completely. The pain was reduced to 1/10. Anti-nausea meds helped with stomach discomfort of Otezla side effects. Fourteen months in, the nausea was getting worse, lasting all day. Tremors. Appetite non-existent. Fatigue and anxiety increasing to unbearable levels. Spending more time in bed than not. Pain returning to joints... especially hands, feet, and lower back. Stopped Otezla three weeks ago. Appetite is back, nausea and diarrhea gone. Anxiety minimal.  Energy level much higher. Was only going to stop Otezla for two weeks. I believe I am done with Otezla. Quality of life decision."