multiple sclerosis
"Copaxone was working great for over 10 years, until the day came that my injection site reaction went anaphylactic.  Not a pleasant experience, especially when health care providers (of which I am/was one) refuse to believe that the only potential exposure agent was Copaxone.  
I would be willing to give it another try (in a controlled hospital setting with emergency medicines on hand), but my neurologist and PCP won't let me.  
If you can take it, site reactions are the only problem I ever had, as they only occurred the last year I was on it.  Side effects were virtually non-existent compared to the other ABC medicines and the new treatment modalities."