obesity
"I am in a clinical research study. I began this in July 2011.  At first I lost a lot of weight quickly (about 15 lbs in 2 months).  I lost 21lbs altogether.  My appetite was nil and my blood pressure went down!  But after about a year, the appetite is back in full swing and blood pressure is going back up.  Have also gained 10 pounds back.  Also still pre-diabetic.  I guess after a while it stops working.  I have 1 more year to go in the study."