osteoarthritis
"I am in the middle of my second course of Euflexxa.  I had it six months ago, and the pain relief was significant.

One thing to note is that your doctor should place the injection exactly where your arthritis is.  No improvement could mean he or she is not doing the injection in the right place.

Another thing to note is that your activity tolerance in the first 48 hours after a Euflexxa shot can vary tremendously.  I think most doctors use local anesthetic, and last shot I "felt fine" and was walking around and using short flights of stairs too much, resulting in severe pain that night (Percocet needed) and still a lot of pain the next day.  The third day I was fine though.

Today I got a shot and I am taking it easy to avoid pain."