pain
"I have arthritis and have tried many over the counter medicines as Aspirin, Motrin, etc.  These medicines increased my diastolic blood pressure upwards of 30 points.  (I already have high blood pressure).  The doctor then tried Oxycodone and again my BP went significantly up.  Hydrocodone had the same result.  As a last resort for a pain med I was given Demerol (50MG).  No increase in BP and no side effects.  It takes upwards of two hours to kick in but does a good job of numbing pain.  Apparently I am sensitive to all NSAIDS. (Non-steroidal anti-inflammatory medications).  "