gout, acute
"This is a useful drug but care must be taken not to take too much when trying to get relief.The maximum start-up dose is usually greater than that needed to create problems in sensitive individuals - or if taken with another (incompatible) drug. I took 6 x 0.5 mg tablets for 2 days recently for an attack of left toe gout whilst starting on Simvastatin (for blood lipid lowering) and ended up with severe diarrhea (without any stomach pain). This knocked back the gout attack also, but cessation of therapy allowed it back with a vengeance and two very bad nights followed.
I have cleared the statin after 2 days - so will start low dose Colchicine again if needed tonight- but keeping to 1-2mg max dose in future."