depression
"When I started Trintellix 2 years ago, within a couple days, my mood and energy improved and the physical side effects were tolerable.  As time went on my energy level went down and I started gaining weight (15 lbs )   My muscles were always aching and I couldn't feel joy or sadness.  I was numb.  Don't ask me why I stayed on it for 2 years.  My cognition was so sharp though.  Maybe that's why.  Trintellix made me a bit paranoid and socially uncomfortable ..  Anyways to make a long story short, I switched to Pristiq 50mg and I'm doing better socially and I'm sleeping through the night.  On Trintellix , I was up at 3 or 4 every morning.  I think I would try Trintellix again if I ever went into a severe depression again.  Take care"