restless legs syndrome
"I am unaware of any severely adverse reactions regarding the use of Tramadol.  I use 50mg two to three times per day for arthritic pain and for restless leg syndrome. I have also found that the more you use your back and legs during the day, (exercise, walking, biking, running) the less symptomatic the restless legs syndrome is. Perhaps there is a connection between the neurological pathology of RLS and exercise.  Maybe the increase in endorphins caused by exercise has something to do with it.  Sorry, I digress.  In the meantime, when RLS is symptomatic, Tramadol is a God send. Tramadol is quite effective as well for arthritic pain.  I wouldn't take anything else."