opioid-induced constipation
"Works well IF you are meticulous with instructions. My notes: Reliable if taken FIRST THING in the morning with nothing else and full glass of water.  Don't eat or ingest for 1+ hrs. If you take a whole tablet after 3-5 days of no BM, expect 4+ bathroom events with 1 life-altering. Don't wait until 5 days have passed.  Take a HALF pill every 2-3 days.  Then two or three fairly normal events.  It will not work as well if you take it later in the day and if you have eaten something that day expect only a 25% function. If you MUST take it later in the day wait for 3 hours after eating and don't eat for several hours. For me it causes slight physical withdrawal symptoms.  Used discount card for $20 copay (online)."