migraine
"I have had migraines for 30 years.  In the last year and a half they went from 15 day/month to practically every day.  Triptans do not work as an abortive for me.  Propananol is the only preventative thus far that has worked - but it stopped working after 4 weeks.  My neurologist prescribed DHE in the injectible form.  I do not like the little glass vials the DHE comes in, breaking them open, and using the syringe.  That said, almost every time I use it, it breaks the migraine.  Unfortunately, it does not always last more than 4-6 hours.  I can get this at my local CVS (though they don't carry it in stock).  I don't notice any side-effects but I generally take a nap afterward to let it do it's thing."