abnormal uterine bleeding
"I have been using the Depo for 2 1/2 years now. I noticed during the first year I would spot lightly when I usually got my period and my cramps went away. After the first year my period pretty much went away for the most part. However, when I do occasionally get spotting, it lasts for about 2 weeks and it comes at random times. In the past year I can recall it happening three times. For me it still beats getting reglar periods and it has taken away my horrible cramps so I deal with it. The pill always made me sick no matter what brand I tried so that is another plus with the Depo.  But everyone is different and everyone will react differently."