chronic pain
"I have been taking narcotics for chronic pain for about 25 years now.  I started with Tylenol with codeine and have progressed through just about everything (morphine, oxycodone, Dilaudid, Oxycontin, Fentanyl patches, etc.).  My pain management doctor had me on 60 mg of Oxycontin 3 X daily and it worked (somewhat) for a while until I developed a tolerance and it too became ineffective.  So the doctor switched me to 16 mg. Exalgo 2 X daily.  I was resistant at first, mainly because of reducing the number of doses per day but after I took it for a few days I was amazed. I don't wake up in excruciating pain anymore and, even though the effects are subtle and come on slowly, it works better in controlling my pain than anything else I've used."