major depressive disorde
"My experience with Remeron is short.
It worked wonders for me, but I stopped it as it causes awful weight gain.
21 pounds in 4 weeks. 
I looked pregnant.  It made me more depressed.
I would just eat. It does something to your brain that makes you feel as though you are never full. 
At night I would sneak food. 
I could not stop. 
I was at 30mg. 
I've heard 15 mg is worse for weight gain. 
Also, this drug is also given to elderly patients who are undergoing chemotherapy and also given to people with eating disorders. (Bulimia and anorexia ) 

As I said. In one respect,  it did Wonders for me with anxiety and depression and stopped the voices in my head and helped me sleep.  
But I couldn't go through gaining any more weight."