depression
"I have been on and off Zoloft (Lustral) for about 8 years.  My usual dose is 200mg but every time I try to come off them depression comes back with a vengeance.  I have severe treatment resistant depression and have had over 60 ECT treatments. Zoloft has been the only antidepressant which has helped me in any way and believe me I have been on them all. But as everyone is different I can't say it will necessarily be the one for you but in my experience of all the tricyclic antidepressants, SSRIs and MAOI's, Zoloft has far outweighed the others.  As I'm here just thought I'd mention that I am also on a new antidepressant called Valdoxan which is very new and also very good. It is available in Europe but I'm not sure if its available in the United States yet. Good luck. "