gout
"I rarely had gout flare ups despite having high levels for 10 years, I couldn't take the allopurinol, and when I started having small more frequent flare ups my doctor urged me to try Uloric, warning me that I was damaging my joints even if I wasn't having flare ups.  The first 4 months on it I had probably 7 flare ups, more than I had ever had before, but my levels were low.  Finally after 6 months they stopped and I have had zero issues for months. I think that what happens is that you build up crystals in your joints over the years if you don't treat your gout, then when you go on this medicine your levels drop so fast that the crystals dissolve and fall out into your joints.  Stick with it, it's worth it.  Not sure what it costs."