bacterial skin infection
"Super bad reaction. TERRIBLE! High fever, loss of appetite, lethargy, brown urine, LIVER INFLAMATION. NO RASH. After 7 days on Bactrim DS, feeling beyond terrible, I did some internet research and suspected drug fever. Ceased taking. Went to my doctor who ran blood tests which confirmed my suspicions. Liver enzymes: 

AST/SGOT	335  H (mine) 14-36 (unit/L) (normal range)

ALT/SGPT	581  H	         9-52 (unit/L)

Alk Phos	        307  H	        38-126 (unit/L)

Levels started to go down after I stopped taking it; it took 3 

months for levels to return to normal. A lot of information says you have a rash with drug reactions. I did NOT. My skin infection did clear up. It wasn't that bad to start with. I asked him for something topical. Was not my regular Doc who prescribed it. My Doc said it was overkill. Just because the guy's a doctor doesn't  mean he is a good doctor! Be your own advocate. Another round of this crap--who knows! Sulfonamides are one of the drugs that can cause a severe reaction"