depression
"I have had treatment-resistant depression for 20 years and have tried Zoloft, Prozac, Effexor, Paxil, Celexa, Wellbutrin, Lexapro and Viibryd.  Lexapro (20 mg) and Wellbutrin (300mg XL) seem to work best but even with talk therapy, good diet and exercise I still have never achieved full remission.  After my psych doctor retired, I switched to another who had me tested for MTHFR mutations and started me on 15mg of Deplin. Within 7 days I felt better than I could ever remember - it was like a light switch!  Test results showed I am homozygous for the C677T MTHFR mutation.  I stopped taking Deplin after some agitation & anxiety started; I restarted on a lower dose before ramping up to 15 again.  I have yet to see the same improvement after 3 weeks."