abnormal uterine bleeding
"I have been on the Depo for 13 yrs and it has been great no periods not even spotting but I did however gain a lot of weight and I have experienced headaches but I just stopped because I have been on it to long, it will cause bone loss I probably experienced a lot of the side effects but nothing worse then bleeding and cramping for months at a time I would have definitely go back to it if I could."