acne
"I’ve been on Loryna for a couple of years now (maybe 3 or 4?). I absolutely LOVE this pill for controlling my acne. It is the only other thing besides daily antibiotics (doxycycline) that have controlled my acne. I tried Sprintec prior to this and it did nothing for my acne. Short term, I have had no side effects from Loryna. No weight gain, no extreme mood swings, nothing. My only complaint and reason for considering switching is that after taking this long term, I recently developed spider veins on my thighs. I have NEVER had such a thing so it was very concerning as I am only 25 and in very good health, and as I know there are increased risks for DVT while taking this drug. Recently the areas on my thigh where the spider veins developed have become somewhat painful at work (as I stand all day). I attribute the development of the spider veins directly to Loryna as this is only medication I have taken the past couple years. It is such a shame because I absolutely love what it has done for my skin (flawless even during the time around my period), but the veins cause a large concern for me so I am heavily considering switching. 
Overall, I love Loryna for the shorter term, however if you plan to be on it for a few years, it may be concerning.

I also know someone else who was on Gianvi (another generic for Yaz) and the same thing happened to her regarding spider/varicose veins."