barrett's esophagus
"I was diagnosed with Barrett's Esophagus six years ago, and regularly used Prilosec for the past 8 years, but I occasionally still had severe heartburn.  Like the last post, I too was prescribed a higher and higher dose until I was taking 4-6 pills a day, still getting occasional heartburn.  Last year I started taking only 40 mg per day of Pantoprazole, and I seldom (less than once a month when I get careless with food and/or alcohol) have had heartburn at all.  I highly recommend asking your doctor about this medication, if you suffer from long term frequent heartburn and Prilosec no longer sees to work as well."