narcolepsy
"I've been on Nuvigil for 4 years and it's stopped being as effective.  I'm currently on 125 mg twice a day, and 37.5 mg Adipex twice a day. The Adipex has absolutely helped my weight (down 14 lbs in 15 days, 40lbs to go) but not much help with the wakefulness.  I'm falling asleep in the afternoon and driving is a nightmare.

It takes A LOT for insurance to cover.  Without all the hoops my doctor has agreed to jump through, it would be $685 per month."