abnormal uterine bleeding
"I have been on depo for about 7 years and am now just switching over to Kyleena (IUD). This was the best birth control for what I needed at the time. At the start I had severe cramps and highly abnormal bleeding. This was the ultimate lifesaver! After about 6 months of abnormal bleeding (this is very common when first starting depo), I stopped having a period all together. I would have given this a 10 if not for the more recent side effects I started experiencing. In the last year or so, I started experiencing a steady state of feeling down/low, easily agitated/quick to anger, and low libido. After some research I found other testimonials of people experiencing the same mood changes after being on depo for 5+ years. Only reason I'm switching."