hypoestrogenism
"I have taken .9 Premarin (natural estrogen) for 23 years (after my uterus was removed at 34 and symptoms developed), and I am just fine (unless I don't take it).  Any attempt to use any oral artificial estrogen made me very sick and the patches left red welts that lasted for months. So I have stayed with oral Premarin, and although I don't appreciate the way horses are treated in order to produce it, I am very grateful that it stops the severe sweating, hot flashes, shakiness and weakness that comes if I miss it for a day or two.  It did not prevent osteoporosis.  I do look 15  years younger than I should - possible good side effect. 23 years and no problems."