depression
"I had been in and out of the hospital for many years, tried all classes of anti depressants and even several in different classes, BICYCLICS, TRICYCLICS, then most of the SSRI's.  After continuing to get worse, my doctor and I decided to try ECT (shock treatment). I received 13 treatments (and no, it was nothing like One Flew Over The Cookoo's Nest lol) but it also didn't help at all.  Thirty years burning down the road,  nowhere to run, got nowhere to go... he, as a last ditch effort, tried Nardil and to almost sound trite, I pulled a full 180 degree turn around. 
There were a few side-effects, some weight gain and a lessor libido and difficulty to orgasm,  though if you knew me now, you'd know NONE of these side effects exist any longer!"