constipation, chronic
"I have had constipation for one year. My Dr. had me try all the usual, after having a colonoscopy. High-fibre diet did not help. Had a CT of abdomen and pelvis, with no problems. Also had a gall bladder scan. 
The first 2 days on Linzess were awful: cramps, bloating, nausea, and unexpected diarrhea. It took about 10 days for me to acclimate. My gastroenterologist tweaked the dose to take the capsule after breakfast. Then, after another adjustment (taking the capsule every other day), everything is fine. Routinely, I do not plan to be away from a bathroom for 2 hours after taking a capsule."