bipolar disorde
"My original experience with Zoloft was over ten years ago, during a serious depressive episode - it seemed to be effective as a stabilizer.  This past December, a doctor prescribed it again to help pull me out of another down-turn.  Within the course of a month I progressed from severe depression to ultradian mood cycling, which resulted in a nervous breakdown.  The cycling abated within a couple weeks of discontinued treatment with Zoloft. "