bipolar disorde
"I'm one of those unlucky people that doesn't really respond to antidepressants, so I need an antipsychotic to stabilize my mood.  I was on Seroquel for a many years but switched after the negative effects of my memory and concentration, which ended up being not so subtle; weight gain and oversleeping came a little while after as well, so I found it was time to switch. This is my best try so far after Seroquel, but that's not saying much.  Having to take this with food   needing to go to sleep pretty much Right After or else getting lost in a paranoid/anxious frenzy/limbo-type state is really quite challenging. I also get tired pretty early which I believe is due to the half-life of the medication (18 hours or so)"