depression
"I've used tricyclics and SSRIs before.  Both caused huge weight gain, and were only moderately effective.  Effexor XR worked very well for me at 150mg for several years.  I was able to lose a small amount of weight, and stopped having late night craving for sugary stuff, and it was very effective in combating the depression symptoms. I slept well but was not lethargic during the day; I took it at night.  Later on I needed to increase my dose. I am now on 300mg, and started losing weight again (a good thing in my case) and have more energy.  It takes longer to have an orgasm but other than that, I've been very lucky in having few to no side effects. The one thing I hate is that if I miss a dose, side effects are AWFUL!"