melanoma, metastatic
"I don't have melanoma but was approved for the trial 2B of Zelboraf due to my BRAF mutation ( I have Pancreatic Adenocarcinoma, unresectable, BRAF mutation ) Scans showed a depreciation in size but I couldn't stay on the study or drug due to the effects.  I was severely nauseous, had and still do haave horrible ugly painful and itchy raised skin lesions that I am still getting after 3 months off of the drug.  I was incapacitated and in bed.  Titrated down twice didn't change anything.  I was immobilized, felt a severe malaise, could barely get out of bed and months later I am still recovering from the effects of taking the drug.  I was pulled from the study by my oncologist due to the toxicity.  This was very disappointing as it affected me as badly as Folfironox; its chemo in a pill. Too bad, really."