opiate withdrawal
"I had to come off 450 mg a day of Tramadol before a pain pump trial, which is coming up shortly.  I thought I was going to lose my marbles for a couple of days when the pain was so intense I couldn't bear it.  Besides a crappy back, I have PLMD and diabetic neuropathy.  I can't take stronger opiates because of allergies.  I learned that the Tramadol helped more with my leg pain than my back pain, though by the time I was totally weaned off a couple of days ago, my back was starting to be pretty sore, too.  I'm taking Tylenol (LOL, what a joke, but it beats nothing), plus 1 mg of clonidine every 8 hours.  For me, it has been quite helpful.  When I was just taking it once a day, I was miserable."