rheumatoid arthritis
"I had rheumatoid arthritis onset literally overnight in wrist, and within short period, all fingers, elbows and shoulders.  I have negative RF, but elevated Sed Rate.  I pushed my Rheumatologist hard to get in front of the disease progression. I was on Methotrexate alone for about 10 wks, increasing dosage from 12.5mg - 17.5mg but it had marginal impact. I pushed for Humira and within 48 hrs after first injection, I noticed improvement.  I'm six weeks into combination therapy and I'd say I'm 60-70% improved.   Large joints are 90% better but fingers remain stubborn.  Yes, the shot hurts for 10 flipping seconds.  I let it get to room temp for about 30-40 minutes..speciality pharmacist said that was fine.  This medicine is awesome."