sjogren's syndrome
"It also took ten years to diagnose correctly.  At first I took 2- 200 mgs of Plaquenil and it gave me an irregular heartbeat.  Discontinued for a few weeks, then rheumy asked me to try again, one 200 mgm every other day. After six weeks had improvement in CRP and sed rate, even though the doc  didn't expect any improvement on that low dose. Then he increased me to one pill each day.  It did increase my migraines so he said to take it before bedtime with anti-anxiety drug.   Side effect.....sleeping much better.....wonderful side effect.  Occasionally I have to take Tylenol during night if headache wakes me up. Now I realize my extreme dry mouth seems slightly improved. Joint pain and foot pain is much better. HAPPY!"