major depressive disorde
"Switched to Pristiq from SSRI after burning through most of the SSRIs and finding Wellbutrin was great but not enough. I had GeneSight and Pristiq and Fetzima were the only green a/ds that were green lighted. Started with 50, side effects waned after a few weeks, but didn't really kick in, so upped to 100 and lowered WB. It was awful. My memory has been destroyed on Pristiq, so I can't tell you what specifically but all of my symptoms worsened. Went right back to 50 and WB 450.

Pristiq is ok. It helped the incredible sadness and hopelessness and affect/flatness, nothingness. Didn't help with motivation, getting out of bed, happiness, socialization, cognition. Switching to Fetzima and crossing fingers."