major depressive disorde
"Pristq. Well. 

It's still early days but I'd like to share my experience already with this medication. (I'm only on 50mg, no idea how in the world people are surviving on 100mg). The first few days can be described basically as absolute hell on earth. The side effects kicked in almost immediately after waking up the morning after taking it (night dose). It honestly felt exactly like coming down hard off ecstasy. I had absolutely no ability to function for hours. Then the nausea, the dizziness, the headaches, the jaw clenching, out of body feeling, feelings of euphoria and depression all at once. In short it was an absolute joy! But it does get better! And it really works a treat. I find myself laughing a lot more, anxiety is half as bad."