 mutations in an enzyme can result in a neomorphic catalytic activity in cancers . 
 we applied cancer - associated mutations from isocitrate dehydrogenases ( idhs ) to homologous residues in the active sites of homoisocitrate dehydrogenases ( hidhs ) to derive enzymes that catalyze the conversion of 2-oxoadipate to ( r)-2-hydroxyadipate , a critical step for adipic acid production . 
 thus , we provide a prototypic example of how insights from cancer genome sequencing and functional studies can aid in enzyme redesign . 
Supplementary Material