acute myocardial infarction ( ami ) is complicated by cardiogenic shock ( cs ) in approximately 510  % of patients [ 1 , 2 ] .
intra - aortic balloon counterpulsation ( iabp ) has been used as a haemodynamic support system for patients with ami complicated by cs since 1968 .
treatment with iabp is supposed to increase cardiac output by more effective emptying of the left ventricle , decreasing workload and thereby oxygen demand of the heart , and to reduce myocardial ischaemia by augmentation of coronary perfusion [ 4 , 5 ] .
evidence for iabp use in patients with ami complicated by cs is largely based upon pathophysiological considerations and non - randomised , small trials of patients treated with thrombolytic therapy .
however , the most recent large randomised trial on the use of iabp in patients with ami complicated by cs showed no benefit on 30-day mortality . as a result , the efficacy of iabp to treat patients with cs has been questioned .
in contrast , an area of increasing interest is the use of iabp in patients with persistent ischaemia ( pi ) after primary pci for ami ( no - reflow phenomenon ) . because pi is thought to be reversible over time ( within hours to days ) , decreasing the workload of the myocardium and increasing coronary blood flow by iabp is suggested to limit the final size of the infarcted territory . in this paper , we report our complete experience with the use of iabp in acute myocardial infarction , either as treatment for cardiogenic shock or to treat persistent ischaemia , over a period of 3  years .
all patients admitted to the catharina hospital eindhoven for primary pci in ami ( with st elevation ) during a 3-year period ( 1 january 2008 to 31 december 2010 ) were studied ( fig .  1 ) . of all patients , we analysed those who survived the interventional procedure and were treated by iabp .
baseline characteristics including cardiovascular risk factors , patient history , electrocardiograms , coronary anatomy , indication for iabp insertion , haemodynamic parameters at time of iabp insertion and possible complications were acquired from patient medical records and local databases.fig .
1flowchart . patients admitted for acute myocardial infarction to the catharina hospital eindhoven , period 20082010 flowchart .
patients admitted for acute myocardial infarction to the catharina hospital eindhoven , period 20082010 patients were retrospectively divided into two subgroups , based on the indication for treatment with iabp , i.e. cs or pi ( without cs ) .
cs was defined as a persistent state of hypotension ( systolic blood pressure < 90  mmhg or mean arterial pressure 30  mmhg lower than baseline ) and clinical signs of cs ( abnormal mental status , cold clammy skin , oliguria ) .
patients in whom iabp was inserted because of mechanical complications of ami ( ventricular septal rupture , papillary muscle rupture ) were assigned to the cs group by definition .
pi was defined as persistent or recurrent chest pain and st elevation despite successful epicardial reperfusion therapy ( no - reflow phenomenon ) , failed primary pci with persistent chest pain and st elevation , or bridge to cabg .
recurrent st elevation was defined as return of st elevation before leaving the catheterisation laboratory after initial regression due to successful reperfusion therapy .
patients presenting with both cs and pi were assigned to the cs group by definition . the datascope 300 cs console , combined with the maquet sensation 7 fr .
40 cc balloon , was used in all patients ( maquet inc , wayne , nj ) .
iabp - related complications were defined as peripheral ischaemia requiring iabp removal ( absence of peripheral pulsation combined with white colouration of the leg on the side of iabp insertion ) , bleeding requiring transfusion or need for vascular surgery , and infection because of iabp insertion ( fever and signs of inflammation , combined with increased c - reactive protein levels ( > 6  mg / l ) ) .
follow - up was obtained at the time of iabp removal , hospital discharge , 30-day and 1-year follow - up .
outcome measures were all - cause mortality within 30  days and all - cause mortality at 1  year .
discrete variables are presented as percentages , while continuous variables are presented as mean  standard deviations .
continuous variables were compared using the student s t test or mann  whitney - u test as appropriate . since hazard ratios of the covariates are not constant over time , we used multivariate regression analysis to identify predictors of 30-day and 1-year mortality .
the patients lost to follow - up were censored at the date of last contact ( in all cases the date of hospital discharge ) .
a limited number of variables were preselected for multivariate regression analysis according to the size of the study population .
the preselected variables were age , cs , cardiopulmonary resuscitation , use of antiarrhythmic drugs , use of inotropic agents and coronary artery bypass grafting ( cabg ) .
the acquired data were analysed using ibm statistical package for social sciences ( spss ) for windows version 19.0.0.1 ( ibm corporation , armonk , ny ) .
all statistical tests were two - tailed and p - value < 0.05 was considered statistically significant .
all patients admitted to the catharina hospital eindhoven for primary pci in ami ( with st elevation ) during a 3-year period ( 1 january 2008 to 31 december 2010 ) were studied ( fig .  1 ) . of all patients , we analysed those who survived the interventional procedure and were treated by iabp .
baseline characteristics including cardiovascular risk factors , patient history , electrocardiograms , coronary anatomy , indication for iabp insertion , haemodynamic parameters at time of iabp insertion and possible complications were acquired from patient medical records and local databases.fig .
1flowchart . patients admitted for acute myocardial infarction to the catharina hospital eindhoven , period 20082010 flowchart .
patients admitted for acute myocardial infarction to the catharina hospital eindhoven , period 20082010 patients were retrospectively divided into two subgroups , based on the indication for treatment with iabp , i.e. cs or pi ( without cs ) .
cs was defined as a persistent state of hypotension ( systolic blood pressure < 90  mmhg or mean arterial pressure 30  mmhg lower than baseline ) and clinical signs of cs ( abnormal mental status , cold clammy skin , oliguria ) .
patients in whom iabp was inserted because of mechanical complications of ami ( ventricular septal rupture , papillary muscle rupture ) were assigned to the cs group by definition .
pi was defined as persistent or recurrent chest pain and st elevation despite successful epicardial reperfusion therapy ( no - reflow phenomenon ) , failed primary pci with persistent chest pain and st elevation , or bridge to cabg .
recurrent st elevation was defined as return of st elevation before leaving the catheterisation laboratory after initial regression due to successful reperfusion therapy .
patients presenting with both cs and pi were assigned to the cs group by definition . the datascope 300 cs console , combined with the maquet sensation 7 fr .
40 cc balloon , was used in all patients ( maquet inc , wayne , nj ) .
iabp - related complications were defined as peripheral ischaemia requiring iabp removal ( absence of peripheral pulsation combined with white colouration of the leg on the side of iabp insertion ) , bleeding requiring transfusion or need for vascular surgery , and infection because of iabp insertion ( fever and signs of inflammation , combined with increased c - reactive protein levels ( > 6  mg / l ) ) .
follow - up was obtained at the time of iabp removal , hospital discharge , 30-day and 1-year follow - up .
outcome measures were all - cause mortality within 30  days and all - cause mortality at 1  year .
discrete variables are presented as percentages , while continuous variables are presented as mean  standard deviations .
continuous variables were compared using the student s t test or mann  whitney - u test as appropriate . since hazard ratios of the covariates are not constant over time , we used multivariate regression analysis to identify predictors of 30-day and 1-year mortality .
the patients lost to follow - up were censored at the date of last contact ( in all cases the date of hospital discharge ) .
a limited number of variables were preselected for multivariate regression analysis according to the size of the study population .
the preselected variables were age , cs , cardiopulmonary resuscitation , use of antiarrhythmic drugs , use of inotropic agents and coronary artery bypass grafting ( cabg ) .
the acquired data were analysed using ibm statistical package for social sciences ( spss ) for windows version 19.0.0.1 ( ibm corporation , armonk , ny ) .
all statistical tests were two - tailed and p - value < 0.05 was considered statistically significant .
in total , 4076 patients were admitted to the hospital for ami . of those patients , 42 ( 1  % ) were moribund and died in the catheterisation laboratory and were excluded from this analysis .
overall in - hospital mortality was 2.6  % . in 239 patients ( 5.9  % ) ,
an iabp was inserted at the catheterisation laboratory during or immediately following the revascularisation procedure ( fig .  1 ) .
reperfusion was achieved in 87  % of the patients receiving iabp ( study population ) , either by primary pci ( 49  % ) or by emergency cabg if primary pci failed or was considered inferior to emergency cabg ( 38  % ) .
table  1 shows the baseline characteristics of these patients and the subgroups based upon indication for iabp insertion ( cs or pi).table 1baseline characteristics of patients receiving intra - aortic balloon counterpulsationtotal ( n  =  239)indication for iabp insertion 
 p - valuecardiogenic shock ( n  =  151)persistent ischaemia ( n  =  88)age ( years)64    1164    1165    110.87male sex ( % ( n))75 ( 180)74 ( 111)78 ( 69)0.40risk factors  hypertension ( % ( n))40 ( 96)38 ( 59)42 ( 37)0.65  diabetes mellitus ( % ( n))20 ( 47)20 ( 30)19 ( 17)0.92  hypercholesterolaemia ( % ( n))24 ( 58)20 ( 30)32 ( 28)0.04  smoking ( % ( n))32 ( 77)31 ( 47)34 ( 30)0.58  renal insufficiency ( % ( n))5 ( 12)4 ( 6)7 ( 6)0.37  peripheral arterial disease ( % ( n))8 ( 20)7 ( 10)11 ( 10)0.20history of  coronary disease ( % ( n))32 ( 77)29 ( 43)39 ( 34)0.11  cva / tia ( % ( n))9 ( 22)9 ( 14)9 ( 8)0.96  atrial fibrillation ( % ( n))3 ( 8)4 ( 6)2 ( 2)0.71systolic blood pressure ( mmhg)96    3080    27121    20<0.01diastolic blood pressure ( mmhg)55    1847    1868    14<0.01heart rate ( beats per minute)92    2295    2584    18<0.01out of hospital cardiac arrest ( % ( n))25 ( 60)32 ( 48)14 ( 12)<0.01mechanical ventilation ( % ( n))23 ( 55)29 ( 44)13 ( 11)<0.01location of stemi 
anterior / septal ( % ( n))43 ( 103)40 ( 61)48 ( 42)0.27  inferior / posterior ( % ( n))34 ( 81)37 ( 56)28 ( 25)0.17  undetermined / pan - ischaemia ( % ( n))22 ( 53)22 ( 33)22 ( 20)0.88three vessel / left main stem coronary disease ( % ( n))62 ( 147)61 ( 92)63 ( 55)0.86mechanical complication ( % ( n))8 ( 20)13 ( 20)0 ( 0)<0.01reperfusion therapy  primary pci ( % ( n))49 ( 118)59 ( 89)33 ( 29)<0.01  cabg ( % ( n))38 ( 91)33 ( 50)47 ( 41)0.04  no reperfusion or thrombolytic therapy ( % ( n))13 ( 30)8 ( 12)21 ( 18)<0.01indication for iabp - implantation  reduction of ischaemia ( % ( n))37 ( 88)0 ( 0)100 ( 88 )  cardiogenic shock ( % ( n))63 ( 151)100 ( 151)0 ( 0)complications during hospitalisation  use of inotropic agents ( % ( n))78 ( 186)93 ( 140)52 ( 46)<0.01  use of antiarrhythmic agents ( % ( n))38 ( 90)45 ( 68)25 ( 22)<0.01  renal failure ( renal replacement therapy ) ( % ( n))3 ( 6)3 ( 5)1 ( 1)0.42iabp running time  1  day ( % ( n))38 ( 91)31 ( 46)51 ( 45)<0.01  1  days ( % ( n))62 ( 148)70 ( 105)49 ( 43)<0.01data are presented as mean  sd or percentagescabg indicates coronary artery bypass grafting ; cva cerebrovascular event , iabp intra - aortic balloon pump , pci percutaneous coronary intervention , stemi st - segment elevation myocardial infarction tia transient ischemic attack baseline characteristics of patients receiving intra - aortic balloon counterpulsation data are presented as mean  sd or percentages cabg indicates coronary artery bypass grafting ; cva cerebrovascular event , iabp intra - aortic balloon pump , pci percutaneous coronary intervention , stemi st - segment elevation myocardial infarction tia transient ischemic attack overall , patients had multiple risk factors for coronary artery disease . at the time of presentation ,
25  % of the patients were resuscitated and 23  % were mechanically ventilated . in 63  % of the patients ,
the baseline systolic and diastolic blood pressures were significantly higher in the patients treated for pi , while the need for inotropic agents ( dobutamine and norepinephrine ) was significantly lower .
the iabp was used during 1  day in 38  % of the patients , 62  % of the patients were supported by iabp 1  days .
there was a relatively low incidence of iabp - related complications of 4  % , due to major bleeding ( 2  % ) and ischaemia ( 2  % ) .
follow - up at 30-days and 1-year was obtained in 98  % of the patients .
four patients ( 2  % ) were lost during follow - up due to transportation to their native country .
cumulative 30-day mortality and 1-year mortality for patients treated with iabp was 26  % and 31  % , respectively .
figure  2 shows the kaplan - meier survival curves of the two groups classified by indication of iabp use .
the patients with cs had a 30-day mortality of 36  % and a 1-year mortality of 41  % .
the patients treated with iabp because of pi had a 30-day mortality of 7  % ; 1-year mortality was 11  % .fig .
panel a shows the kaplan meier curve of the patients treated with iabp for cs .
panel b shows the kaplan meier curve of the patients treated with iabp for pi one - year survival of patients treated with intra - aortic balloon counterpulsation .
panel a shows the kaplan meier curve of the patients treated with iabp for cs .
panel b shows the kaplan meier curve of the patients treated with iabp for pi the results from the multivariate regression analyses are shown in table  2 .
the presence of cs ( or , 4.7 ; 95  % ci , 1.812.4 ) was independently associated with higher 30-day mortality.table 2multivariate regression analyses of 30-day survival in all patients treated with iabp and 1-year survival in patients who survived until weaning of iabp30-day follow up1-year follow upor95  % ci 
 p - valueor95  % ci 
 p - valueage1.031.001.060.061.041.01.080.03cardiogenic shock4.71.812.40.0021.80.74.60.19cpr1.80.83.70.132.21.05.30.06anti - arrhythmic drugs1.10.52.20.801.20.52.70.65inotropic agents2.90.99.70.082.60.78.90.14cabg0.30.10.60.0020.30.10.80.01cabg indicates coronary artery bypass grafting ; ci confidence intervals , cpr cardiopulmonary resuscitation , iabp intra - aortic balloon pump , or odds ratio multivariate regression analyses of 30-day survival in all patients treated with iabp and 1-year survival in patients who survived until weaning of iabp cabg indicates coronary artery bypass grafting ; ci confidence intervals , cpr cardiopulmonary resuscitation , iabp intra - aortic balloon pump , or odds ratio for long - term survival , we performed a subanalysis of all patients successfully weaned from iabp after haemodynamic stabilisation ( table  2 ) .
older age ( or , 1.04 ; 95  % ci , 1.01.08 ) was independently associated with higher 1-year mortality . in both 30-day mortality ( or , 0.3
; 95  % ci , 0.10.6 ) and 1-year mortality ( or , 0.3 ; 95  % ci , 0.10.8 ) , cabg was an independent predictor for better survival .
in total , 4076 patients were admitted to the hospital for ami . of those patients , 42 ( 1  % ) were moribund and died in the catheterisation laboratory and were excluded from this analysis .
overall in - hospital mortality was 2.6  % . in 239 patients ( 5.9  % ) ,
an iabp was inserted at the catheterisation laboratory during or immediately following the revascularisation procedure ( fig .  1 ) .
reperfusion was achieved in 87  % of the patients receiving iabp ( study population ) , either by primary pci ( 49  % ) or by emergency cabg if primary pci failed or was considered inferior to emergency cabg ( 38  % ) .
table  1 shows the baseline characteristics of these patients and the subgroups based upon indication for iabp insertion ( cs or pi).table 1baseline characteristics of patients receiving intra - aortic balloon counterpulsationtotal ( n  =  239)indication for iabp insertion 
 p - valuecardiogenic shock ( n  =  151)persistent ischaemia ( n  =  88)age ( years)64    1164    1165    110.87male sex ( % ( n))75 ( 180)74 ( 111)78 ( 69)0.40risk factors  hypertension ( % ( n))40 ( 96)38 ( 59)42 ( 37)0.65  diabetes mellitus ( % ( n))20 ( 47)20 ( 30)19 ( 17)0.92  hypercholesterolaemia ( % ( n))24 ( 58)20 ( 30)32 ( 28)0.04  smoking ( % ( n))32 ( 77)31 ( 47)34 ( 30)0.58  renal insufficiency ( % ( n))5 ( 12)4 ( 6)7 ( 6)0.37  peripheral arterial disease ( % ( n))8 ( 20)7 ( 10)11 ( 10)0.20history of  coronary disease ( % ( n))32 ( 77)29 ( 43)39 ( 34)0.11  cva / tia ( % ( n))9 ( 22)9 ( 14)9 ( 8)0.96  atrial fibrillation ( % ( n))3 ( 8)4 ( 6)2 ( 2)0.71systolic blood pressure ( mmhg)96    3080    27121    20<0.01diastolic blood pressure ( mmhg)55    1847    1868    14<0.01heart rate ( beats per minute)92    2295    2584    18<0.01out of hospital cardiac arrest ( % ( n))25 ( 60)32 ( 48)14 ( 12)<0.01mechanical ventilation ( % ( n))23 ( 55)29 ( 44)13 ( 11)<0.01location of stemi 
anterior / septal ( % ( n))43 ( 103)40 ( 61)48 ( 42)0.27  inferior / posterior ( % ( n))34 ( 81)37 ( 56)28 ( 25)0.17  undetermined / pan - ischaemia ( % ( n))22 ( 53)22 ( 33)22 ( 20)0.88three vessel / left main stem coronary disease ( % ( n))62 ( 147)61 ( 92)63 ( 55)0.86mechanical complication ( % ( n))8 ( 20)13 ( 20)0 ( 0)<0.01reperfusion therapy  primary pci ( % ( n))49 ( 118)59 ( 89)33 ( 29)<0.01  cabg ( % ( n))38 ( 91)33 ( 50)47 ( 41)0.04  no reperfusion or thrombolytic therapy ( % ( n))13 ( 30)8 ( 12)21 ( 18)<0.01indication for iabp - implantation  reduction of ischaemia ( % ( n))37 ( 88)0 ( 0)100 ( 88 )  cardiogenic shock ( % ( n))63 ( 151)100 ( 151)0 ( 0)complications during hospitalisation  use of inotropic agents ( % ( n))78 ( 186)93 ( 140)52 ( 46)<0.01  use of antiarrhythmic agents ( % ( n))38 ( 90)45 ( 68)25 ( 22)<0.01  renal failure ( renal replacement therapy ) ( % ( n))3 ( 6)3 ( 5)1 ( 1)0.42iabp running time  1  day ( % ( n))38 ( 91)31 ( 46)51 ( 45)<0.01  1  days ( % ( n))62 ( 148)70 ( 105)49 ( 43)<0.01data are presented as mean  sd or percentagescabg indicates coronary artery bypass grafting ; cva cerebrovascular event , iabp intra - aortic balloon pump , pci percutaneous coronary intervention , stemi st - segment elevation myocardial infarction tia transient ischemic attack baseline characteristics of patients receiving intra - aortic balloon counterpulsation data are presented as mean  sd or percentages cabg indicates coronary artery bypass grafting ; cva cerebrovascular event , iabp intra - aortic balloon pump , pci percutaneous coronary intervention , stemi st - segment elevation myocardial infarction tia transient ischemic attack overall , patients had multiple risk factors for coronary artery disease . at the time of presentation ,
25  % of the patients were resuscitated and 23  % were mechanically ventilated . in 63  % of the patients ,
the baseline systolic and diastolic blood pressures were significantly higher in the patients treated for pi , while the need for inotropic agents ( dobutamine and norepinephrine ) was significantly lower .
the iabp was used during 1  day in 38  % of the patients , 62  % of the patients were supported by iabp 1  days .
there was a relatively low incidence of iabp - related complications of 4  % , due to major bleeding ( 2  % ) and ischaemia ( 2  % ) .
follow - up at 30-days and 1-year was obtained in 98  % of the patients .
four patients ( 2  % ) were lost during follow - up due to transportation to their native country .
cumulative 30-day mortality and 1-year mortality for patients treated with iabp was 26  % and 31  % , respectively .
figure  2 shows the kaplan - meier survival curves of the two groups classified by indication of iabp use .
the patients with cs had a 30-day mortality of 36  % and a 1-year mortality of 41  % .
the patients treated with iabp because of pi had a 30-day mortality of 7  % ; 1-year mortality was 11  % .fig .
panel a shows the kaplan meier curve of the patients treated with iabp for cs .
panel b shows the kaplan meier curve of the patients treated with iabp for pi one - year survival of patients treated with intra - aortic balloon counterpulsation .
panel a shows the kaplan meier curve of the patients treated with iabp for cs .
panel b shows the kaplan meier curve of the patients treated with iabp for pi the results from the multivariate regression analyses are shown in table  2 .
the presence of cs ( or , 4.7 ; 95  % ci , 1.812.4 ) was independently associated with higher 30-day mortality.table 2multivariate regression analyses of 30-day survival in all patients treated with iabp and 1-year survival in patients who survived until weaning of iabp30-day follow up1-year follow upor95  % ci 
 p - valueor95  % ci 
 p - valueage1.031.001.060.061.041.01.080.03cardiogenic shock4.71.812.40.0021.80.74.60.19cpr1.80.83.70.132.21.05.30.06anti - arrhythmic drugs1.10.52.20.801.20.52.70.65inotropic agents2.90.99.70.082.60.78.90.14cabg0.30.10.60.0020.30.10.80.01cabg indicates coronary artery bypass grafting ; ci confidence intervals , cpr cardiopulmonary resuscitation , iabp intra - aortic balloon pump , or odds ratio multivariate regression analyses of 30-day survival in all patients treated with iabp and 1-year survival in patients who survived until weaning of iabp cabg indicates coronary artery bypass grafting ; ci confidence intervals , cpr cardiopulmonary resuscitation , iabp intra - aortic balloon pump , or odds ratio for long - term survival , we performed a subanalysis of all patients successfully weaned from iabp after haemodynamic stabilisation ( table  2 ) . older age ( or , 1.04 ; 95  % ci , 1.01.08 ) was independently associated with higher 1-year mortality . in both 30-day mortality ( or , 0.3 ; 95  % ci , 0.10.6 ) and 1-year mortality ( or , 0.3 ; 95  % ci , 0.10.8 ) , cabg was an independent predictor for better survival .
this study describes iabp use in a population of consecutive patients over a 3-year period presenting with ami , in whom either cardiogenic shock or persistent ischaemia was present after ( successful or failed ) primary pci .
it does not compare two groups of patients , but solely reflects on two different indications of iabp use .
on the one hand , it confirms the poor outcome of cs , but at the same time , it opens the window for a potentially better treatment of another group of patients with a poor prognosis , i.e. patients with persistent ischaemia . in patients with cs , 30-day survival was 64  % , in accordance with the existing literature [ 7 , 9 ] .
in contrast , in patients with pi 30-day survival and 1-year survival were high ( 93  % and 89  % , respectively ) .
although there are no randomised data in the literature to compare survival of patients treated with iabp for pi , survival of patients with pi treated medically is much worse [ 10 , 11 ] .
reperfusion by cabg was independently associated with better 30-day survival , most likely because of selection bias through acceptance for emergency cabg . in this study , there were few complications of iabp use ( 4  % ) , comparable with the percentage of complications in the iabp - shock ii trial .
patients treated with iabp in our study who met the criteria of cs had a 30-day survival of 64  % , which is in line with the recent iabp - shock ii trial , showing a 30-day survival of 61  % .
these survival rates are high when compared with other , older studies [ 12 , 13 ] , most likely because of the high percentage of early revascularisation ( 90  % ) [ 14 , 15 ] .
the iabp - shock ii trial was the first randomised controlled trial on the use of iabp in patients presenting with ami complicated by cs where reperfusion was achieved mostly by pci and showed no reduction in short - term mortality .
the study was underpowered due to the 30-day mortality which was significantly lower than expected .
also , there was a relatively high rate of crossover in the control group ( 10  % ) and there was a trend towards an increase in the use of left ventricular assist devices in the control group .
these limitations are inherent in such a study in  back - against - the - wall patients , but could mask the potential benefit of iabp use .
nonetheless , these results question if iabp deserves its place as routine treatment of patients with ami complicated by cs , but do not exclude a beneficial effect in some patients .
the challenge is to find a way to distinguish between those patients and not abandon such a potentially life - saving treatment regardlessly .
at least , it can be expected that a beneficial effect of augmented diastolic pressure only plays a role in case of pi with exhausted autoregulation . in case of cs without pi ,
use of iabp after successful epicardial reperfusion complicated by pi ( no - reflow phenomenon ) , or after failed pci , is an area which has not been investigated extensively .
this no - reflow phenomenon is attributable to a variety of factors , including micro - embolisation , spasm , intramyocardial oedema and other entities incompletely understood , but leading to enlargement of the area of myocardial necrosis . in a number of these patients ,
dramatic relief of ischaemia occurs after insertion of iabp , most likely due to afterload reduction and augmentation of myocardial blood flow . since coronary autoregulation is completely exhausted in these patients , myocardial blood flow is directly dependent on perfusion pressure . because of that exhausted flow reserve , a positive effect of augmented perfusion pressure is well conceivable .
described a 30-day mortality of 12  % in 64 patients who suffered from severely impaired myocardial blush grade after pci for ami .
mehta et al . confirmed this poor prognosis with a 1-year mortality of 23  % in patients with stemi undergoing primary pci with final timi   2 flow .
because of this poor prognosis , the value of attempts to relieve pi is undisputable . in our study , patients treated with iabp for pi had a favourable 30-day survival of 93  % and a 1-year survival of 89  % . since this study was performed retrospectively , there is no control group .
outcome data can therefore only be compared with the historical data , but are favourable and mandate further randomised studies in such patients with stemi undergoing primary pci complicated by pi .
favourable long - term survival rates have been described after iabp support in myocardial infarctions in non - randomised studies .
a randomised trial ( crisp - ami ) on adjunctive iabp therapy to limit infarct size in patients with ami in the absence of cs , failed to show benefit of iabp treatment .
all - cause mortality at 6  months was less in the iabp group ( 1.9  % versus 5.2  % ; p  =  0.12 ) , but was not statistically significant due to the low rate of events ( underpowered study ) .
we believe iabp should not be used regularly in every patient presenting with ami , but there might be a subset of patients  those with pi or no - reflow  who might benefit from iabp support . in the presence of pi , this potentially detrimental phenomenon might be bridged by using iabp to reduce workload and oxygen demand of the myocardium and increase myocardial perfusion . in this context , it has been speculated in the literature whether timing of initiation of iabp support is important , i.e. just before or after opening of the occluded artery .
a recent study with respect to timing did not show any significant differences in odds of mortality .
this study is a retrospective analysis of all ami patients but with two fundamentally different characteristics ( cs and pi ) .
there are no matched - control groups and the results of iabp treatment in both groups had to be compared with historical data .
furthermore , in the setting of no - reflow , additional medical therapy is sometimes suggested , such as abciximab or verapamil . in our study
verapamil was used in 4 patients , while gp iib / iiia inhibitors were used only in 13 patients because of angiographic signs of distal embolisation .
nevertheless , this analysis of iabp use includes all consecutive patients with ami during 3  years within one large heart centre , is not limited to the traditional cs patients but also studied systematically patients with pi and is hypothesis - generating for the future .
patients treated with iabp in our study who met the criteria of cs had a 30-day survival of 64  % , which is in line with the recent iabp - shock ii trial , showing a 30-day survival of 61  % .
these survival rates are high when compared with other , older studies [ 12 , 13 ] , most likely because of the high percentage of early revascularisation ( 90  % ) [ 14 , 15 ] .
the iabp - shock ii trial was the first randomised controlled trial on the use of iabp in patients presenting with ami complicated by cs where reperfusion was achieved mostly by pci and showed no reduction in short - term mortality .
the study was underpowered due to the 30-day mortality which was significantly lower than expected .
also , there was a relatively high rate of crossover in the control group ( 10  % ) and there was a trend towards an increase in the use of left ventricular assist devices in the control group .
these limitations are inherent in such a study in  back - against - the - wall patients , but could mask the potential benefit of iabp use .
nonetheless , these results question if iabp deserves its place as routine treatment of patients with ami complicated by cs , but do not exclude a beneficial effect in some patients .
the challenge is to find a way to distinguish between those patients and not abandon such a potentially life - saving treatment regardlessly .
at least , it can be expected that a beneficial effect of augmented diastolic pressure only plays a role in case of pi with exhausted autoregulation . in case of cs without pi ,
use of iabp after successful epicardial reperfusion complicated by pi ( no - reflow phenomenon ) , or after failed pci , is an area which has not been investigated extensively .
this no - reflow phenomenon is attributable to a variety of factors , including micro - embolisation , spasm , intramyocardial oedema and other entities incompletely understood , but leading to enlargement of the area of myocardial necrosis . in a number of these patients ,
dramatic relief of ischaemia occurs after insertion of iabp , most likely due to afterload reduction and augmentation of myocardial blood flow . since coronary autoregulation is completely exhausted in these patients , myocardial blood flow is directly dependent on perfusion pressure . because of that exhausted flow reserve , a positive effect of augmented perfusion pressure is well conceivable .
described a 30-day mortality of 12  % in 64 patients who suffered from severely impaired myocardial blush grade after pci for ami .
mehta et al . confirmed this poor prognosis with a 1-year mortality of 23  % in patients with stemi undergoing primary pci with final timi   2 flow .
because of this poor prognosis , the value of attempts to relieve pi is undisputable . in our study , patients treated with iabp for pi had a favourable 30-day survival of 93  % and a 1-year survival of 89  % . since this study was performed retrospectively , there is no control group .
outcome data can therefore only be compared with the historical data , but are favourable and mandate further randomised studies in such patients with stemi undergoing primary pci complicated by pi .
favourable long - term survival rates have been described after iabp support in myocardial infarctions in non - randomised studies . a randomised trial ( crisp - ami ) on adjunctive iabp therapy to limit infarct size in patients with ami in the absence of cs , failed to show benefit of iabp treatment .
all - cause mortality at 6  months was less in the iabp group ( 1.9  % versus 5.2  % ; p  =  0.12 ) , but was not statistically significant due to the low rate of events ( underpowered study ) .
we believe iabp should not be used regularly in every patient presenting with ami , but there might be a subset of patients  those with pi or no - reflow  who might benefit from iabp support . in the presence of pi , this potentially detrimental phenomenon might be bridged by using iabp to reduce workload and oxygen demand of the myocardium and increase myocardial perfusion . in this context
, it has been speculated in the literature whether timing of initiation of iabp support is important , i.e. just before or after opening of the occluded artery .
a recent study with respect to timing did not show any significant differences in odds of mortality .
this study is a retrospective analysis of all ami patients but with two fundamentally different characteristics ( cs and pi ) .
there are no matched - control groups and the results of iabp treatment in both groups had to be compared with historical data .
furthermore , in the setting of no - reflow , additional medical therapy is sometimes suggested , such as abciximab or verapamil . in our study , none of these drugs were systematically investigated .
verapamil was used in 4 patients , while gp iib / iiia inhibitors were used only in 13 patients because of angiographic signs of distal embolisation .
nevertheless , this analysis of iabp use includes all consecutive patients with ami during 3  years within one large heart centre , is not limited to the traditional cs patients but also studied systematically patients with pi and is hypothesis - generating for the future .
in this large retrospective study in 4076 consecutive patients presenting with acute myocardial infarction during 3  years , iabp was used in 6  % ( n  =  239 ) of all cases because of two different indications : cardiogenic shock ( 3.8  % ) or persistent ischaemia ( 2.2  % ) .
outcome in patients with persistent ischaemia was favourable when compared with historical data , and mandates further prospective studies .
this work was supported by the dutch technology foundation stw ( stichting voor de technische wetenschappen ) under project number 11052 .
 backgroundrecent evidence questions the role of intra - aortic balloon counterpulsation ( iabp ) in the treatment of acute myocardial infarction ( ami ) complicated by cardiogenic shock ( cs ) . 
 an area of increasing interest is the use of iabp for persistent ischaemia ( pi ) . 
 we analysed the use of iabp in patients with ami complicated by cs or pi.methodsfrom 2008 to 2010 , a total of 4076 patients were admitted to our hospital for primary percutaneous coronary intervention ( pci ) for ami . out of those , 
 239 patients received an iabp either because of cs or because of pi . 
 characteristics and outcome of those patients are investigated.resultsthe mean age of the study population was 64    11  years ; 75  % were male patients . 
 of the patients , 63  % had cs and 37  % had pi . 
 patients with cs had a 30-day mortality rate of 36  % ; 1-year mortality was 41  % . 
 patients with pi had a 30-day mortality rate of 7  % ; 1-year mortality was 11  % .conclusionsmortality in patients admitted for primary pci because of ami complicated by cs is high despite iabp use . 
 outcome in patients treated with iabp for pi is favourable and mandates further prospective studies . 
Introduction
Methods
Patient population
Follow-up and data collection
Statistical analysis
Results
Baseline characteristics and in-hospital outcome
Thirty-day and one-year follow-up
Discussion
IABP as treatment of cardiogenic shock
IABP as treatment of persistent ischaemia
Limitations
Conclusions
Funding