 chlordimeform is a relatively new acaricide / insecticide , whose mode of action we have investigated . 
 it appears to interfere with amine - mediated control of nervous and endocrine systems in a variety of ways . 
 specifically , chlordimeform causes a build - up of the amines 5-hydroxytryptamine and to a lesser extent norepinephrine in the rat brain in vivo , antagonizes the in vivo action of reserpine in the rat ( reserpine depletes amine stores in the cns ) , inhibits monoamine oxidase from rat liver in vitro , and causes hypotension in rabbits . in the american cockroach 
 it directly stimulates the heart in situ , acts synergistically with tryptamine in vivo , inhibits amine - n - acetyltransferase from cockroach head in vitro , causes accumulation of indolamines in cockroaches in vivo , and blocks the stimulation of adenylate cyclase by octopamine in the cockroach cns in situ . 
 it also inhibits tryptamine metabolism in whole mites in vitro.imagesfigure 3.figure 4 . 
 afigure 4 . 
 bfigure 4 . 
 cfigure 4 . 
 d 
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