cardiovascular prevention and rehabilitation improves functional and clinical status , health - related quality of life , and prognosis in patients with coronary heart disease ( chd ) recovering from acute events and invasive interventions.1 for more than a decade , cardiac rehabilitation ( cr ) has been recommended for chd as part of integrated cardiac care.2,3 despite this , studies from the us and europe , including denmark , have documented that less than half of eligible patients participate in cr.4 systematic monitoring of delivery and outcomes of cr is recommended to meet this challenge.5,6 thus , the national working group on preventive cardiology and rehabilitation , under the danish society of cardiology , initiated a national clinical quality registry on cr approved by the danish health and medicines authority , in 2011 .
although danish cardiac rehabilitation database ( dhrd ) was initially implemented on september 1 , 2013 , as a result of a breakdown of the database system , data collection ceased until august 14 , 2015 , at which point the database was implemented once again .
the overall aim of the dhrd is to monitor and improve the quality of phase ii cr throughout denmark , in order to improve the outcome for patients recovering from cardiac events .
phase ii cr in denmark refers to the initial 812 weeks of outpatient cr performed at hospitals and municipalities .
data are collected at a patient level as well as program level ( figure 1 ) , as recommended by scientific associations in europe and the us.5,6 furthermore , the database aims to support research within the field of cr .
it is mandatory for all hospitals delivering phase ii cr to register all patients onto the dhrd , who are discharged alive and receiving cr following hospitalization for chd ( ie , acute coronary syndrome , or stable angina pectoris with proven stenosis on coronary angiography treated with percutaneous coronary intervention , coronary artery bypass grafting , or medication alone ) .
all patients discharged alive from hospitals are identified from the national patient register7 using the who s international classification of diseases , 10th edition ( icd-10 ) coding system : acute coronary syndrome ( st - elevation myocardial infarction , non  st - elevation myocardial infarction , and unstable angina ) as primary diagnosis , or secondary diagnoses ( di210di219 , di248 , di240 , di249 ) and stable angina pectoris as primary diagnoses ( di209 , di251 , di251b , di251c ) .
furthermore , the nordic classification of surgical procedures is used to identify coronary angiograms and invasive procedures ( coronary angiograms : uxac40 , uxac85 , uxac90 , uxuc85 , uxuc86 , uxuc87 , ufya20 ; percutaneous coronary intervention : kfng00 , kfng02 , kfng02a , kfng05 , kfng05a , kfng10 , kfng12 , kfng20 , kfng22 , kfng30 , kfng40 , kfng96 , kzfx01 ; and coronary artery bypass grafting : kfna , kfnb , kfnc , kfnd , kfne , kfnf , kfnh , kfnj , kfnk , kfnw ) .
the database will include information on approximately 14,000 patients annually . based on administrative data on ambulatory visits ( ie ,
data from the danish national patient register7 cross - checked with procedure codes referring to cr services ) , 75% of eligible patients are receiving one or more outpatient rehabilitation services from all 35 hospitals in the five regions of denmark that were delivering cr in denmark by 2013.8 the database is also capable of including other patient groups receiving cr .
patient - level data are collected by the clinical team and registered directly onto an online system at the time of entry into phase ii cr .
the team comprises multidisciplinary professionals involved in the rehabilitation intervention ( ie , nurses , medical doctors , physiotherapists , and dieticians ) . to minimize the registration workload and
double registration , simultaneous linkage to national administrative patient registers has been established ( the danish civil registration system,9 the danish national patient register,7 and the danish national database of reimbursed prescriptions).10 linkage to the clinical laboratory information system11 is also planned . at baseline ,
data are captured from the aforementioned registers and then validated and approved by the clinical staff , by reading and validating the captured information .
registration of data into the dhrd began on august 14 , 2015 , which led to the collection of data on 3,846 patients by march 2016 .
the quality of data is assessed as part of an annual data audit with feedback to clinicians .
patient - level data are collected by the clinical team and registered directly onto an online system at the time of entry into phase ii cr .
the team comprises multidisciplinary professionals involved in the rehabilitation intervention ( ie , nurses , medical doctors , physiotherapists , and dieticians ) . to minimize the registration workload and
double registration , simultaneous linkage to national administrative patient registers has been established ( the danish civil registration system,9 the danish national patient register,7 and the danish national database of reimbursed prescriptions).10 linkage to the clinical laboratory information system11 is also planned . at baseline , data are captured from the aforementioned registers and then validated and approved by the clinical staff , by reading and validating the captured information .
registration of data into the dhrd began on august 14 , 2015 , which led to the collection of data on 3,846 patients by march 2016 .
the quality of data is assessed as part of an annual data audit with feedback to clinicians .
the variables recorded in the dhrd are related to patient characteristics at baseline , for example , smoking status , exercise capacity , height , weight , blood pressure , and pharmacological therapy . also , data on performed diagnostic tests ( eg , diabetes and depression ) are recorded in the database , along with the individual plan for rehabilitation ( eg , training sessions , dietary treatment , and/or smoking cessation ) . data on physical capacity , lifestyle , and patient - reported outcome measures are reentered at follow - up , in order to monitor progression and outcome of cr .
the data collected are aligned with the european core cr dataset ( mcgee , unpublished data , 2004 ) and the variables of european cardiac rehabilitation database project , in order to make sure that data from denmark can be compared to data from other european countries .
data at a program level are collected every third year through surveys targeted at cr staff .
these surveys gather information about the structure and provision of cr , and provide program - level information that can be compared with patient outcome over time .
a set of outcome variables has been defined and approved nationally , in order to provide a set of benchmark quality indicators .
the performance on the quality indicators is published in annual feedback reports at a national , regional , and hospital level as part of the annual audit of cr . the indicator list and
benchmarks are subject to regular adjustments , in order to keep the database in line with current evidence .
the database has been implemented since the summer of 2015 ; consequently , the first patient - level data will be available by autumn 2016 .
applications for access to use data are reviewed by the chair and executive committee upon application to the danish clinical registries . in the short term ,
program - level data and administrative data have been presented as part of an annual report from dhrd8 and will be analyzed as part of an implementation research program investigating the gap between guidelines , clinical practice , and use of a clinical registry.12 data are collected and maintained according to danish data protection laws and regulations , without the need to obtain patient consent .
the dhrd was initiated by the national working group on preventive cardiology and rehabilitation , under the danish society of cardiology , and was approved as a national clinical quality registry on cr by the danish health and medicines authority in 2011 .
the dhrd is supported by the cross - disciplinary professional associations : the danish society of cardiology , the danish nurses organisation , the association of danish physiotherapists , and the danish association of clinical dieticians .
the database is available at www.danheart.dk ; however , this web site can only be accessed through the danish hospital internet networks .
the danish clinical registries , which constitutes the infrastructure of the danish national clinical quality registries , has responsibility for the maintenance of majority of the data and data protection , as well as seeking funding .
the database is headed by a steering committee with an elected chair , an executive committee , and an academic secretariat .
data are collected and maintained according to danish data protection laws and regulations , without the need to obtain patient consent .
the dhrd was initiated by the national working group on preventive cardiology and rehabilitation , under the danish society of cardiology , and was approved as a national clinical quality registry on cr by the danish health and medicines authority in 2011 .
the dhrd is supported by the cross - disciplinary professional associations : the danish society of cardiology , the danish nurses organisation , the association of danish physiotherapists , and the danish association of clinical dieticians .
the database is available at www.danheart.dk ; however , this web site can only be accessed through the danish hospital internet networks .
the danish clinical registries , which constitutes the infrastructure of the danish national clinical quality registries , has responsibility for the maintenance of majority of the data and data protection , as well as seeking funding .
the database is headed by a steering committee with an elected chair , an executive committee , and an academic secretariat .
the national dhrd , aimed at monitoring and improving the quality of cr programs , has recently been established in denmark .
the dhrd is unique due to the direct and simultaneous linkages to the administrative hospital registers .
this resource makes follow - up on clinically important outcomes , such as the number of hospitalizations and mortality rate , directly accessible .
accreditation by use of clinical quality registries has been pointed out as an important tool to improve clinical practice within cr and clinical follow - up care13 ( figure 2 ) , and referral to cr has been added as a performance measure following acute coronary syndrome by the european society of cardiology and the american heart association.14,15 the growing literature indicates that clinical quality registries can provide vital information that can be used to facilitate improvements in practice16 with positive effects primarily on the processes of care , whereas measures on outcome of care are less often positively affected.16 findings , however , are heterogeneous , indicating that neither a registry itself nor the reporting of data initiates change as quality improvement requires comprehensive approaches,17 including successful implementation of the registry and continuous data quality assurance , as well as transparency and timely feedback.18 based on experiences from the field of stroke care , embracing a comprehensive quality assurance approach , including a culture with focus on quality , thorough data entry , and availability of feedback as well as willingness to act on feedback , is critical in order to achieve improved quality of care.18 this can not be achieved by dhrd alone , but is a shared responsibility of the cr team and the health care sector . the dhrd includes all hospitals offering cr and will , therefore , reflect all hospital - based cr services at a national level .
since 2007 , the municipalities in denmark have had the overall responsibility for prevention and rehabilitation following discharge .
cr services were , hence , transferred from hospitals to the municipalities ( either partly or fully ) in 2007 .
quality assurance and accreditation of municipality - based cr will , therefore , become an important focus for dhrd in the future .
a high reporting and coverage rate of patients with chd is , therefore , essential .
coverage of the database will be closely monitored and routinely evaluated by matching data to the administrative data in the danish national patient register.7 the aim is to achieve > 90% coverage of cr activities in all cr programs .
dhrd is an online , clinical quality database that aims toward providing higher quality cr for patients with chd in denmark .
data can be assessed as a part of research related to both the outcome and organization of cr .
 aim of databasethe danish cardiac rehabilitation database ( dhrd ) aims to improve the quality of cardiac rehabilitation ( cr ) to the benefit of patients with coronary heart disease ( chd).study populationhospitalized patients with chd with stenosis on coronary angiography treated with percutaneous coronary intervention , coronary artery bypass grafting , or medication alone . reporting is mandatory for all hospitals in denmark delivering cr . 
 the database was initially implemented in 2013 and was fully running from august 14 , 2015 , thus comprising data at a patient level from the latter date onward.main variablespatient - level data are registered by clinicians at the time of entry to cr directly into an online system with simultaneous linkage to other central patient registers . 
 follow - up data are entered after 6 months . 
 the main variables collected are related to key outcome and performance indicators of cr : referral and adherence , lifestyle , patient - related outcome measures , risk factor control , and medication . 
 program - level online data are collected every third year.descriptive databased on administrative data , approximately 14,000 patients with chd are hospitalized at 35 hospitals annually , with 75% receiving one or more outpatient rehabilitation services by 2015 . 
 the database has not yet been running for a full year , which explains the use of approximations.conclusionthe dhrd is an online , national quality improvement database on cr , aimed at patients with chd . 
 mandatory registration of data at both patient level as well as program level is done on the database . 
 dhrd aims to systematically monitor the quality of cr over time , in order to improve the quality of cr throughout denmark to benefit patients . 
Aim of database
Study population
Data collection
Main variables
Follow-up
Examples of research
Ethics, funding, and administrative issues
Discussion
Conclusion