telestroke is becoming a widespread and fast growing practice model for increasing access to thrombolysis .
the european stroke organisation and the american heart association / american stroke association have both issued guidelines encouraging the formation of telestroke networks and development of teleconsultation services .
hubandspoke  model , whereby 1 or more regional centers provide expertise via a telecommunication link to peripheral centers .
these models may be challenging to implement in largely rural landscapes , where transport links to regional centers present difficulties .
the east of england is a large , predominantly rural region covering 7500 square miles , a population of 5.6 million people , and approximately 6000 stroke patients , annually .
prior to the current telemedicine set up in november 2010 , there were 2 regional centers providing thrombolysis 7 days a week , 24 hours a day .
projected ambulance travel time of 45 to 60 minutes from peripheral centers to either one of these 2 regional centers ruled out a 2hub model of telestroke in our region .
this motivated horizontal organization of the program , which was rolled out following successful completion of a pilot project between september 2009 and january 2010 .
figures from the department of health , uk suggest that 5% of stroke patients are thrombolyzed on average across the country . in our region alone
, by increasing the thrombolysis rates to an average of 10% , the estimated cost savings to the national health service ( nhs ) would be nearly  2.7 million , by preventing longterm disability .
based on figures from the european safe implementation of treatments in stroke ( sits ) database for our region for 20092010 , 382 stroke patients received thrombolysis for stroke .
thus , for an average annual load of 6000 cases , average overall thrombolysis rates are 6.36% across the region .
the east of england telestroke project is hosted jointly by the cambridge university hospitals nhs foundation trust and the regional strategic health authority .
the program runs across 7 hospitals ( figure ) , namely , ipswich hospital , james paget university hospital , lister hospital , peterborough hospital , queen elizabeth hospital , watford general hospital , and west suffolk hospital .
all these hospitals are classified as district general hospitals with an inpatient capacity of approximately 500 beds . detailed bed size figures and annual emergency attendance numbers , as obtained from the nhs information centre for health and social care , are outlined in the figure .
each of these hospitals runs their own thrombolysis rotas during working hours with onsite stroke specialists .
the main objective of the telemedicine service is to provide realtime , outofhours access to thrombolysis , ie , evenings ( 17:00 to 08:00 ) , weekends and bank holidays .
a regional rota of 10 stroke specialists from across the sites has been created to deliver the service .
all participating specialists had attended regional thrombolysis training days , had access to case discussions in peerreview format via regional videoconferencing meetings and were registered users for the european safe implementation of treatments in stroke ( sits ) database .
thrombolysis was administered as per standard clinical guidelines and the time window for thrombolysis was 0 to 4.5 hours .
definition of symptomatic intracranial haemorrhage ( sich ) was the same as that from the ninds trial , ie , any deterioration in neurological status accompanied by intracranial haemorrhage .
geographical organization of the east of england telestroke network . as per data from national health service ( nhs ) information centre for health and social care , annual overall emergency attendances ( case load for all emergency cases , not stroke alone ) and hospital bed size for each of the participating sites is shown for 20092010 , except for lister hospital for which these figures were not available and thus 20122013 figures have been mentioned . the telemedicine cart , provided to the emergency departments of participating hospitals , is comprised of of a pc in a bespoke mobile trolley ( parity medical ) with an additional highresolution cctv camera mounted on top of the screen .
each consultant has access to a 17 laptop coupled to the telemedicine cart using visimeet videoconferencing software , allowing rapid access to the virtual consultation  room  accessed by a wired / less connection to a dedicated server on a secure nhs ( n3 ) network .
the clinical team at the participating hospital can view and speak to the remote telestroke consultant via the cart , using the camera that can be controlled from both sides .
the telemedicine project was reviewed and approved by the institutional review boards at the individual hospitals and the strategic health authority for administration of thrombolysis via standard clinical guidelines .
verbal consent was obtained from the patient or next of kin prior to telemedicine consultation .
the project was registered with the institutional review boards at each site for prospective audit data collection , for the pilot phase , and subsequently for the first year of service rollout .
mean values with standard deviations ( sd ) and median values with interquartile ranges ( iqr ) are reported here with comparisons between patients in  thrombolysis  and  no thrombolysis 
groups , using 2sample t tests and wilcoxon rank sum test where appropriate , alongside 2sided p values .
the east of england telestroke project is hosted jointly by the cambridge university hospitals nhs foundation trust and the regional strategic health authority .
the program runs across 7 hospitals ( figure ) , namely , ipswich hospital , james paget university hospital , lister hospital , peterborough hospital , queen elizabeth hospital , watford general hospital , and west suffolk hospital .
all these hospitals are classified as district general hospitals with an inpatient capacity of approximately 500 beds . detailed bed size figures and annual emergency attendance numbers , as obtained from the nhs information centre for health and social care , are outlined in the figure .
each of these hospitals runs their own thrombolysis rotas during working hours with onsite stroke specialists .
the main objective of the telemedicine service is to provide realtime , outofhours access to thrombolysis , ie , evenings ( 17:00 to 08:00 ) , weekends and bank holidays .
a regional rota of 10 stroke specialists from across the sites has been created to deliver the service .
all participating specialists had attended regional thrombolysis training days , had access to case discussions in peerreview format via regional videoconferencing meetings and were registered users for the european safe implementation of treatments in stroke ( sits ) database .
thrombolysis was administered as per standard clinical guidelines and the time window for thrombolysis was 0 to 4.5 hours .
definition of symptomatic intracranial haemorrhage ( sich ) was the same as that from the ninds trial , ie , any deterioration in neurological status accompanied by intracranial haemorrhage .
geographical organization of the east of england telestroke network . as per data from national health service ( nhs ) information centre for health and social care , annual overall emergency attendances ( case load for all emergency cases , not stroke alone ) and hospital bed size for each of the participating sites is shown for 20092010 , except for lister hospital for which these figures were not available and thus 20122013 figures have been mentioned .
the telemedicine cart , provided to the emergency departments of participating hospitals , is comprised of of a pc in a bespoke mobile trolley ( parity medical ) with an additional highresolution cctv camera mounted on top of the screen .
each consultant has access to a 17 laptop coupled to the telemedicine cart using visimeet videoconferencing software , allowing rapid access to the virtual consultation  room  accessed by a wired / less connection to a dedicated server on a secure nhs ( n3 ) network .
the clinical team at the participating hospital can view and speak to the remote telestroke consultant via the cart , using the camera that can be controlled from both sides .
the telemedicine project was reviewed and approved by the institutional review boards at the individual hospitals and the strategic health authority for administration of thrombolysis via standard clinical guidelines .
verbal consent was obtained from the patient or next of kin prior to telemedicine consultation .
the project was registered with the institutional review boards at each site for prospective audit data collection , for the pilot phase , and subsequently for the first year of service rollout .
all data were analyzed using ibm spss 19 for mac . mean values with standard deviations ( sd ) and median values with interquartile ranges ( iqr ) are reported here with comparisons between patients in  thrombolysis  and  no thrombolysis  groups , using 2sample t tests and wilcoxon rank sum test where appropriate , alongside 2sided p values .
for safety and feasibility assessment , a pilot phase was run between september 2009 and january 2010 across 4 regional hospitals .
mean ( range ) consultation length was 30 ( 10 to 70 ) minutes for the cases that received treatment versus 18 ( 2 to 55 ) minutes for the others .
mean age of patients was 72 years ( range 54 to 88 ) , median nihss 13 , mean doortoneedle time 56 minutes , mean onsettoneedle time 131 minutes and there were no symptomatic hemorrhages ; asymptomatic hemorrhage rate was 13.3% . following on from the successful pilot phase , 164 consultations were recorded between november 2010 and november 2011 .
clinical data were incomplete for 22 cases ; hence , 142 cases ( table 1 ) are included in this report .
mean ( sd ) age of  thrombolysis  group was 69.4 ( 14.3 ) years ; for  no thrombolysis 
median nihss was higher ( 10 versus 5 , p=0.006 ) in the  thrombolysis  group .
for the  thrombolysis  group , median ( iqr ) doortoneedle time was 94 ( 72 to 113.5 ) minutes and median ( iqr ) onsettoneedle time was 169 ( 141.5 to 201.5 ) minutes .
baseline characteristics of patients in the telestroke cohort mean call duration available for 89 cases overall ; n=50 thrombolyzed cases and n=39 for cases not thrombolyzed .
iqr indicates interquartile ranges ; ninds , national institute of neurological disorders and stroke ; nihss , national institutes of health stroke scale . among the 68 cases that did not receive thrombolysis , 18 were stroke mimics including migraine , seizures , and functional illness .
reasons for not treating patients with a final diagnosis of stroke included uncertain time of onset ( n=7 ) , severe stroke with comorbidities and high hemorrhage risk ( n=4 ) , low nihss at presentation and/or improving neurological deficit at the time of assessment ( n=23 ) , 1 recognized contraindications for thrombolysis ( n=10 ) , hemorrhage on initial ct ( n=6 ) , age with comorbidities ( n=1 , age=93 years ) . in 2 cases ,
we also provide a comparison of our performance against figures from major published telestroke series across the world ( table 2 ) .
comparison of thrombolysis figures from representative published telestroke programs around the world and the east of england ( eoe ) project telemedicine / telephone only consultations .
quarterly audit figures for thrombolysis rates prior to and post commencement of telemedicine are available for 5 of the 7 hospitals ( table 3 ) . note that the pretelemedicine figures represent daytime thrombolysis activity as these hospitals did not have an outofhours service before telemedicine was set up .
quarterly thrombolysis figures from audit data prior to and after roll out of the telemedicine service note that these figures were not available for 2 of the 7 hospitals , namely lister hospital and watford hospital .
pre thrombolysis rates represent daytime activity whereas post telemedicine rates , when the thrombolysis service became 247 , are overall rates including daytime and outofhours work .
our series demonstrates that a locally based model for telestroke consultations is deliverable and safe .
the novelty of this structure is that local stroke physicians participate in the regional service ; thus delivery is not dependent on regional centers .
this has advantages for local specialists in that they retain competencies in treating sufficient numbers of thrombolysis cases , even though their own services are relatively small ; while more effectively sharing the burden of overnight call for lowfrequency , highimpact events . also , it has potential logistic advantages in organizing followup care . this hubless model of organization of our telestroke network is what distinguishes it from the majority of other successfully running telestroke services across the world . keeping services local has particular advantages in relatively large rural landscapes by minimizing dependence on regional transport services and developing rehabilitation and followup care for patients closer to where they live .
our figures compare well with published telemedicine series , apart from slightly longer doortoneedle and onsettoneedle time , which may partly be a reflection of our geographical location and transport challenges .
while our door to scan times are comparable to published ukwide time metrics from the sits database for a similar time period ( median onsettoneedle=150 minutes , doortoneedle=65 minutes , doortoscan=31 minutes ) and the stroke improvement national audit programme published by the royal college of physicians , uk ( median doortoneedle=60 minutes , doortoscan=32 minutes ) , our doortoneedle and onsettoneedle times could be improved further .
attempts , such as involvement of onsite specialist nurses , are underway for further improvement . however , the differences need to be interpreted in light of the fact that the telemedicine service runs for outofhours only and direct comparisons or outofhours figures are not available for each site or separately from national audit figures . our teleconsultation thrombolysis rate ( 52.1% ) approaches the highest figure reported to date , from the finnish telestroke network ( 57.5% ) and compares well with earlier models such as tempis ( 29.8% ) and reach ( 15.5% ) .
the high rate of thrombolysis may suggest that the service may be currently underutilized . besides , the number of overall consultations in the first year of service roll out is smaller than some of the wellestablished telestroke projects like tempis .
thus , our model has potential for a greater impact on thrombolysis delivery with further establishment of its role . as outlined earlier
table 3 shows an increase in thrombolysis activity for the hospitals , where quarterly audit data for overall thrombolysis rates were available before and after commencing telemedicine .
symptomatic hemorrhage rate of 7.3% is at par with other series and early trial data ( table 2 ) . also , noteworthy
is that no cases of inhospital mortality occurred due to hemorrhage , indicating safety of the approach .
mean call duration data ( available for n=89 cases ; table 1 ) did not differ between the 2 groups ( p=0.395 ) .
it would be interesting to examine whether there is meaningful variability in how well the network works for different hospitals and whether the success depends on local expertise and/or varying patient populations .
while table 3 highlights this variability , the sample size for the project data is too small to examine such factors for each site individually .
currently , the project is successfully running across 14 hospitals , from which further clinical data collection is in progress .
in summary , the east of england telestroke project has demonstrated safe and efficacious delivery of an outofhours thrombolysis service across regional hospitals in a large rural landscape .
genevieve dalton , east of england strategic health authority and anglia stroke and heart network , for support with management issues .
s.a . was supported by a national institute of health research biomedical centre grant to clinical neurosciences , cambridge , uk .
 backgroundthe majority of established telestroke services are based on  hubandspoke 
  models for providing acute clinical assessment and thrombolysis . 
 we report results from the first year of the successful implementation of a locally based telemedicine network , without the need of 1 or more hub hospitals , across a largely rural landscape.methods and resultsfollowing a successful pilot phase that demonstrated safety and feasibility , the east of england telestroke project was rolled out across 7 regional hospitals , covering an area of 7500 square miles and a population of 5.6 million to enable outofhours access to thrombolysis . between november 2010 and november 2011 , 
 142 telemedicine consultations were recorded outofhours . 
 seventyfour ( 52.11% ) cases received thrombolysis . 
 median ( iqr ) onsettoneedle and doortoneedle times were 169 ( 141.5 to 201.5 ) minutes and 94 ( 72 to 113.5 ) minutes , respectively . 
 symptomatic hemorrhage rate was 7.3% and stroke mimic rate was 10.6%.conclusionswe demonstrate the safety and effectiveness of a horizontal networking approach for stroke telemedicine , which may be applicable to areas where traditional  
 hubandspoke  
 models may not be geographically feasible . 
Introduction
Methods
Organization of the Network
Technology and Process
Approvals
Statistical Analysis
Results
Discussion
Conclusion
Acknowledgments