we performed a secondary data analysis of the 2006 wave of the health and retirement study ( hrs ) .
the hrs is a biennial longitudinal health interview survey designed to study health transitions in u.s .
it is sponsored by the national institute on aging and performed by the institute for social research at the university of michigan . of the 18,469 respondents eligible for the 2006 wave of the hrs interview , a random one - half sample ( n = 8,379 ) of noninstitutionalized respondents
we limited the study to the 5,991 respondents who were 53 years of age ( the age group with nationally representative sample weights ) and who had valid hba1c measurements ( 76.5% of eligible respondents 53 years of age ) .
respondents not eligible for the enhanced face - to - face interview included 224 nursing home residents , 459 people who required proxy respondents , and 508 people interviewed by telephone only .
the hrs was approved by the behavioral sciences committee institutional review board at the university of michigan .
hrs data are publicly available and contain no unique identifiers , thus ensuring respondent anonymity . as part of the enhanced face - to - face interview , hba1c was measured with random blood samples collected by trained interviewers ( 19 ) .
instructions and kits from biosafe laboratories ( chicago , il ) , a clinical laboratory improvement amendments  certified laboratory ( 19 ) , were used for blood acquisition and hba1c determination .
the biosafe hba1c assay was not ngsp certified and had an expected normal range of 3.85.9% compared with 4.06.0% for ngsp - certified hba1c assays ( 20 ) .
we considered respondents to have diabetes if they reported having received a physician diagnosis of diabetes , regardless of their hba1c results ( n = 1,270 ) .
we divided respondents who did not self - report diabetes into three groups : 1 ) normoglycemia ( hba1c < 5.7% [ 39 mmol / mol ] , n = 2,752 ) , 2 ) prediabetes ( hba1c 5.76.4% [ 3946 mmol / mol ] , n = 1,803 ) , and 3 ) undiagnosed diabetes ( hba1c 6.5% [ 48 mmol / mol ] , n = 166 ) .
we calculated the body mass index ( bmi ) for the 5,962 respondents having both measured height and measured weight .
there were 29 respondents who either weighed 300 lb or were unable to stand ; we used self - reported heights or weights to calculate their bmis .
respondents self - reported their sociodemographic characteristics , including age , sex , race , marital status , educational achievement , and net worth ( i.e. , total household assets  current debt ) .
respondents also self - reported their comorbidities , which included both chronic diseases and geriatric conditions .
we assessed the following seven chronic diseases : hypertension , arthritis , coronary artery disease , cancer ( excluding minor skin cancers ) , psychiatric disorders , chronic lung disease , and stroke .
we considered a chronic disease to be present if 1 ) a respondent reported having received a physician diagnosis and 2 ) the disease was active or severe ( e.g. , requiring medications for treatment ) on the basis of follow - up questions about the disease .
we assessed six geriatric conditions based on the following criteria : cognitive impairment : with the use of a performance - based measure adapted from the telephone interview for cognitive status ( 21 ) , we defined respondents as cognitively impaired if they had dementia ( a score of 06 on the 27-point cognitive scale ) or mild cognitive impairment ( a score of 711 ) .
falls : a fall resulting in injury or falling two or more times in the past 2 years .
each respondent was asked to report his or her difficulty with performing physical tasks because of a health condition .
a physical function limitation was present if a respondent reported yes or ca nt do to any one of the following tasks : 1 ) 5 activities of daily living ( adls ) ( bathing , dressing , eating , transferring , and toileting ) ; 2 ) 5 instrumental adls ( iadls ) ( meal preparation , shopping for groceries , managing medications , making telephone calls , and managing finances ) ; and 3 ) 12 higher - level physical function items based on rosow and breslau ( 22 ) and nagi ( 23 ) ( rbn ) tasks ( walking 1 blocks ; climbing 1 flights of stairs without resting ; running [ or jogging ] 1 mile ; sitting for 2 h ; getting up from a chair after sitting for long periods ; stooping , kneeling , or crouching ; reaching or extending arms above shoulder level ; pulling or pushing large objects such as a living room chair ; lifting a weight > 10 lb ; and picking up a dime from the table ) . to adjust for the complex sample design of the hrs , the differential probability of participation in the enhanced face - to - face interview , and lack of valid response from eligible respondents , all analyses were weighted with the use of stata 9.0 ( stata corp , college station , tx ) software to produce national population estimates .
we used standard descriptive methods ( frequencies , means , and ses ) to estimate the prevalence of sociodemographic characteristics , physical function limitations , and comorbidities by glycemic status ( i.e. , normoglycemia , prediabetes , diabetes ) .
then we compared two glycemic groups separately to focus on pairwise differences ( prediabetes vs. normoglycemia and prediabetes vs. diabetes ) .
we used latent class factor analysis to identify discrete latent variables that best grouped the 12 higher - level physical function ( rbn ) tasks together ( 24 ) .
we selected models based on the smallest bayesian information criterion and akaike information criterion with best model fit ( p > 0.05 ) and highest r. using the best model , we categorized respondents as belonging to one of three rbn groups : 1 ) mobility limitation ( respondents reporting difficulty in walking several blocks and/or climbing a flight of stairs ) , 2 ) lower - extremity limitation ( respondents reporting difficulty with getting up from a sitting position and/or stooping , kneeling , or crouching ) , and 3 ) upper - extremity limitation ( respondents reporting difficulty with pulling or pushing large objects and/or lifting > 10 lb ) .
if a respondent had a physical function limitation in one of the three rbn groups , then he or she was considered part of that group .
if a respondent had multiple physical function limitations , he or she was considered to be part of more than one rbn group .
we used logistic regression models to determine the odds of respondents with prediabetes having physical function limitations as defined by the three rbn groups , with the normoglycemia group serving as the reference . for comparison
, we also determined the odds of respondents with diabetes having physical function limitations compared with those with normoglycemia .
the models were adjusted for age , sex , bmi , and chronic diseases to examine whether prediabetes would independently predict limitations in physical functioning .
we performed sensitivity analyses by including the 166 respondents with undiagnosed diabetes in the diabetes group or by excluding them ; the results did not change .
we also performed sensitivity analyses to define the three glycemic groups accounting for the small difference in the expected normal hba1c range for the biosafe hba1c assay relative to the ngsp criteria .
we divided respondents who did not self - report diabetes into three groups : 1 ) normoglycemia ( hba1c < 5.6% [ 38 mmol / mol ] n = 2,283 ) , 2 ) prediabetes ( hba1c
5.66.3% [ 3845 mmol / mol ] , n = 1,497 ) , and 3 ) undiagnosed diabetes ( hba1c 6.4% [ 46 mmol / mol ] , n = 227 ) . the results did not change ; therefore , we present the results with the original hba1c classification for the three glycemic groups .
as part of the enhanced face - to - face interview , hba1c was measured with random blood samples collected by trained interviewers ( 19 ) .
instructions and kits from biosafe laboratories ( chicago , il ) , a clinical laboratory improvement amendments  certified laboratory ( 19 ) , were used for blood acquisition and hba1c determination .
the biosafe hba1c assay was not ngsp certified and had an expected normal range of 3.85.9% compared with 4.06.0% for ngsp - certified hba1c assays ( 20 ) .
we considered respondents to have diabetes if they reported having received a physician diagnosis of diabetes , regardless of their hba1c results ( n = 1,270 ) .
we divided respondents who did not self - report diabetes into three groups : 1 ) normoglycemia ( hba1c < 5.7% [ 39 mmol / mol ] , n = 2,752 ) , 2 ) prediabetes ( hba1c 5.76.4% [ 3946 mmol / mol ] , n = 1,803 ) , and 3 ) undiagnosed diabetes ( hba1c 6.5% [ 48 mmol / mol ] , n = 166 ) .
we calculated the body mass index ( bmi ) for the 5,962 respondents having both measured height and measured weight .
there were 29 respondents who either weighed 300 lb or were unable to stand ; we used self - reported heights or weights to calculate their bmis .
respondents self - reported their sociodemographic characteristics , including age , sex , race , marital status , educational achievement , and net worth ( i.e. , total household assets  current debt ) .
respondents also self - reported their comorbidities , which included both chronic diseases and geriatric conditions .
we assessed the following seven chronic diseases : hypertension , arthritis , coronary artery disease , cancer ( excluding minor skin cancers ) , psychiatric disorders , chronic lung disease , and stroke .
we considered a chronic disease to be present if 1 ) a respondent reported having received a physician diagnosis and 2 ) the disease was active or severe ( e.g. , requiring medications for treatment ) on the basis of follow - up questions about the disease .
we assessed six geriatric conditions based on the following criteria : cognitive impairment : with the use of a performance - based measure adapted from the telephone interview for cognitive status ( 21 ) , we defined respondents as cognitively impaired if they had dementia ( a score of 06 on the 27-point cognitive scale ) or mild cognitive impairment ( a score of 711 ) . falls : a fall resulting in injury or falling two or more times in the past 2 years .
each respondent was asked to report his or her difficulty with performing physical tasks because of a health condition .
a physical function limitation was present if a respondent reported yes or ca nt do to any one of the following tasks : 1 ) 5 activities of daily living ( adls ) ( bathing , dressing , eating , transferring , and toileting ) ; 2 ) 5 instrumental adls ( iadls ) ( meal preparation , shopping for groceries , managing medications , making telephone calls , and managing finances ) ; and 3 ) 12 higher - level physical function items based on rosow and breslau ( 22 ) and nagi ( 23 ) ( rbn ) tasks ( walking 1 blocks ; climbing 1 flights of stairs without resting ; running [ or jogging ] 1 mile ; sitting for 2 h ; getting up from a chair after sitting for long periods ; stooping , kneeling , or crouching ; reaching or extending arms above shoulder level ; pulling or pushing large objects such as a living room chair ; lifting a weight > 10 lb ; and picking up a dime from the table ) .
to adjust for the complex sample design of the hrs , the differential probability of participation in the enhanced face - to - face interview , and lack of valid response from eligible respondents , all analyses were weighted with the use of stata 9.0 ( stata corp , college station , tx ) software to produce national population estimates .
we used standard descriptive methods ( frequencies , means , and ses ) to estimate the prevalence of sociodemographic characteristics , physical function limitations , and comorbidities by glycemic status ( i.e. , normoglycemia , prediabetes , diabetes ) .
then we compared two glycemic groups separately to focus on pairwise differences ( prediabetes vs. normoglycemia and prediabetes vs. diabetes ) .
we used latent class factor analysis to identify discrete latent variables that best grouped the 12 higher - level physical function ( rbn ) tasks together ( 24 ) .
we selected models based on the smallest bayesian information criterion and akaike information criterion with best model fit ( p > 0.05 ) and highest r. using the best model , we categorized respondents as belonging to one of three rbn groups : 1 ) mobility limitation ( respondents reporting difficulty in walking several blocks and/or climbing a flight of stairs ) , 2 ) lower - extremity limitation ( respondents reporting difficulty with getting up from a sitting position and/or stooping , kneeling , or crouching ) , and 3 ) upper - extremity limitation ( respondents reporting difficulty with pulling or pushing large objects and/or lifting > 10 lb ) . if a respondent had a physical function limitation in one of the three rbn groups , then he or she was considered part of that group .
if a respondent had multiple physical function limitations , he or she was considered to be part of more than one rbn group .
we used logistic regression models to determine the odds of respondents with prediabetes having physical function limitations as defined by the three rbn groups , with the normoglycemia group serving as the reference . for comparison
, we also determined the odds of respondents with diabetes having physical function limitations compared with those with normoglycemia .
the models were adjusted for age , sex , bmi , and chronic diseases to examine whether prediabetes would independently predict limitations in physical functioning .
we performed sensitivity analyses by including the 166 respondents with undiagnosed diabetes in the diabetes group or by excluding them ; the results did not change .
we also performed sensitivity analyses to define the three glycemic groups accounting for the small difference in the expected normal hba1c range for the biosafe hba1c assay relative to the ngsp criteria .
we divided respondents who did not self - report diabetes into three groups : 1 ) normoglycemia ( hba1c < 5.6% [ 38 mmol / mol ] n = 2,283 ) , 2 ) prediabetes ( hba1c
5.66.3% [ 3845 mmol / mol ] , n = 1,497 ) , and 3 ) undiagnosed diabetes ( hba1c 6.4% [ 46 mmol / mol ] , n = 227 ) .
the results did not change ; therefore , we present the results with the original hba1c classification for the three glycemic groups .
the prevalence of prediabetes as defined by hba1c in respondents 53 years of age was 29% , representing 21 million u.s .
of adults 65 years of age , 33% were estimated to have prediabetes , representing 12 million adults .
the mean age of the adults with prediabetes was 67.6 years , which was higher than those with normoglycemia ( p < 0.001 ) , although nearly one - half ( 46% ) of respondents with prediabetes were 5364 years of age .
respondents with prediabetes were more likely to be female than in the other two groups ( p < 0.001 ) .
they were more likely than respondents with normoglycemia but less likely than respondents with diabetes to be black or hispanic and to have less education , a lower net worth , a higher bmi , more chronic diseases , and more geriatric conditions ( p < 0.001 ) .
adults 53 years of age and older by glycemic status like respondents with normoglycemia or diabetes , respondents with prediabetes were likely to have the same leading chronic diseases and geriatric conditions , including hypertension ( 48% ) , arthritis ( 26% ) , chronic pain ( 36% ) , and falls ( 23% ) .
thirty - six percent of respondents with prediabetes reported two or more chronic diseases compared with 28% of those with normoglycemia and 50% of those with diabetes ( all p < 0.001 ) .
additionally , 20% of respondents with prediabetes had at least mild cognitive impairment compared with 13% of those with normoglycemia and 24% of those with diabetes ( all p < 0.001 ) .
figure 2 shows the prevalence of physical function limitations as measured by the 12 rbn tasks , any adls , and any iadls by glycemic status .
the pattern of physical function limitations among the three glycemic groups was similar ; all respondents were most likely to report difficulty running 1 mile ; stooping , kneeling , or crouching ; and climbing several flights of stairs . among respondents with prediabetes ,
84% reported difficulty with running 1 mile ; 47% with stooping , kneeling , or crouching ; and 46% with climbing several flights of stairs .
fourteen percent of respondents with prediabetes reported difficulty with at least one adl , which was significantly fewer than those with diabetes but more than those with normoglycemia ( all p < 0.001 ) .
weighted percentages were derived with the use of hrs respondent population weights to adjust for differential probability of selection into the sample and differential nonresponse .
p values are from  test for the association between the indicated variables and the three glycemic groups .
p < 0.01 when comparing the three glycemic groups and prediabetes vs. diabetes . * p < 0.02 comparing respondents with prediabetes vs. normoglycemia .
respondents with diabetes had the highest prevalence of physical function limitations as measured by the 12 rbn tasks , any adls , and any iadls ; this was followed by respondents with prediabetes and then those with normoglycemia .
this pattern was statistically significant for each physical function task ( all p < 0.01 ) .
subgroup analyses showed that respondents with prediabetes had a significantly higher prevalence of limitations for 10 of the 12 rbn tasks ( except for sitting for 2 h and picking up a dime ) , any adls , and any iadls than those with normoglycemia ( p  0.02 ) ( data not shown ) .
fewer respondents with prediabetes than those with diabetes reported any physical function limitations ( p < 0.002 ) .
the pattern of physical function limitations for men and women is similar to that shown in fig .
the prevalence was highest among diabetic respondents , lower in prediabetic respondents , and lowest in those with normoglycemia regardless of sex ( p < 0.01 for each physical function task ) .
we grouped the 12 rbn tasks into three rbn groups ( see statistical analysis ) to simplify the analysis and presentation . among respondents with prediabetes ,
32% reported difficulty with walking several blocks and/or climbing a flight of stairs ( mobility limitation group ) , 56% reported difficulty with getting up from a chair and/or stooping , kneeling , or crouching ( lower - extremity limitation group ) , and 33% reported difficulty with pulling or pushing large objects and/or lifting > 10 lb ( upper - extremity limitation group ) .
table 2 shows the odds of respondents with prediabetes and diabetes reporting physical function limitations according to the three rbn groups compared with those with normoglycemia . in the unadjusted model ( model 1 ) ,
respondents with prediabetes compared with normoglycemia had a higher odds of having limitations in all three rbn groups , any adls , and any iadls ( odds ratio [ or ] 1.351.48 , p < 0.01 ) .
after adjusting for age and sex ( model 2 ) , there was a slight reduction in the odds of limitations among all physical function groups .
the odds of having a limitation in mobility remained statistically significant after adjusting for age , sex , and bmi ( model 3 ) . when chronic diseases were added ( model 4 ) , the odds of having limitations in mobility were no longer statistically significant . by comparison ,
respondents with diabetes had consistently higher odds of physical function limitations than those with normoglycemia in all three rbn groups , any adls , and any iadls , even after adjusting for age , sex , bmi , and chronic diseases ( 1.461.93 , p < 0.01 ) .
the c statistic ( area under the curve ) to assess model fit for all physical function limitations ( model 4 for each ) was > 0.72 , confirming good model fit .
with the use of the ada - recommended definition based on hba1c measurement , we estimated the prevalence of prediabetes in a nationally representative sample of u.s . adults .
adults 53 years of age have prediabetes . confirming our hypothesis , we found that individuals with prediabetes had more physical function limitations and comorbidities than those with normoglycemia but fewer than those with diabetes .
estimates of prediabetes prevalence based on assessment of impaired fasting glucose , impaired glucose tolerance , and hba1c , which range from 15 to 43% for adults 45 years of age ( 3 ) .
our estimate that 33% of adults 65 years of age have prediabetes is higher than the 26% estimate from the 2005 to2008 national health and nutrition examination survey ( nhanes ) ( 3 ) .
although both the hrs and the nhanes are population - based health surveys , the hrs includes a larger sample of middle - aged and older adults , which may partially explain the different estimates in these two samples .
we were able to analyze hrs data for > 1,800 adults 53 years of age with prediabetes , whereas nhanes included only 696 adults 18 years of age with prediabetes .
other potential reasons for the different estimates are different study methods and respondent characteristics . like a prior study that identified individuals with prediabetes based on impaired fasting glucose or impaired glucose tolerance criteria ( 9 )
, we found that adults with prediabetes were older , had lower educational attainment , and a higher bmi than those with normoglycemia .
however , we found that women were more likely to have prediabetes than men likely because this population was older than that in the prior study and because there were more women in the older age group .
the findings further highlight the high prevalence of prediabetes among middle - aged and older adults .
we have furthered the understanding of physical function limitations and comorbidities associated with glycemic abnormalities by including the full spectrum of individuals with normoglycemia , prediabetes , and diabetes in our analysis .
previous studies described the high rates of physical function limitations ( 12,13 ) and comorbidities ( 14,15,25,26 ) among adults with diabetes but not among those with prediabetes .
the present finding of a high level of physical function limitation among adults with prediabetes is consistent with a previous report on older mexican americans with the metabolic syndrome ( 27 ) .
furthermore , the present results support the hypothesis that diabetes diagnosis may lag the development of its associated complications and physical function limitations , suggesting that interventions are needed early , before diabetes diagnosis , to delay or prevent the development of complications and physical function limitations .
our findings have important implications for the design of lifestyle interventions for middle - aged and older adults at risk for diabetes .
clinical trials such as the dpp ( 5 ) and the finnish diabetes prevention study ( 28 ) demonstrated that intensive lifestyle interventions can effectively delay or prevent diabetes .
however , adults with multiple comorbidities and physical function limitations were excluded from these trials because their comorbidities and functional limitations might interfere with their participation in the interventions ( 29 ) . as demonstrated in the present study , comorbidities that might preclude participation in intensive lifestyle interventions were prevalent among adults with prediabetes .
more than one - third of the respondents reported chronic pain , one - fourth reported arthritis requiring medical treatment , nearly 20% were found to have at least mild cognitive impairment , and nearly one - fourth reported having had an injurious fall or two or more falls in the past 2 years . furthermore , because nearly one - third of respondents with prediabetes reported difficulty walking several blocks or climbing a flight of stairs , they would have been excluded from the dpp because it excluded subjects who were unable to walk 0.25 mile in 10 min ( 30 ) . because most lifestyle interventions involve brisk walking , if not jogging or cycling ( 29 )
, we would expect that most , if not all the respondents with prediabetes might have difficulty in performing this activity .
physical function limitations were prevalent among respondents with prediabetes ( 32 and 56% had mobility limitations and lower - extremity limitations , respectively ) .
more women than men reported physical function limitations ( walking several blocks 32 vs. 23% , stooping , kneeling , or crouching 52 vs. 40% ) .
women may be especially limited in their ability to participate in lifestyle interventions . although age , sex , obesity , and chronic diseases partially explained the difference in physical function limitation between respondents with prediabetes and respondents with normoglycemia
a major strength of this study is that it involved a large , nationally representative sample of middle - aged and older adults ; therefore , the results can be generalized to the u.s .
geriatric conditions , such as chronic pain , falls , and cognitive impairment , often are not considered to be chronic diseases and , thus , have not been well investigated ( 9 ) .
however , these conditions are associated with physical disability ( 16 ) and can certainly affect the ability of individuals to participate in lifestyle interventions .
the hrs did not determine fasting plasma glucose ( fpg ) levels or perform oral glucose tolerance tests ( ogtts ) .
although the ada and other expert panels recommend the use of hba1c to identify adults with prediabetes and diabetes , a number of studies identified discordance among fpg , ogtt , and hba1c ( 31,32 ) . on the other hand ,
the use of hba1c for epidemiologic studies has advantages over fpg or ogtt , including convenience , less day - to - day variability , and international standardization ( 31 ) .
second , the hrs used self - reported data to define diabetes , other chronic diseases , geriatric conditions , and physical function limitations .
the data chosen for this study were limited by the questions included in the hrs and were not verified by medical record review .
we were unable to determine the severity of the conditions on the basis of the responses .
third , only 76.5% of the eligible respondents were included in the study because others did not consent to the study or provide valid hba1c measurements .
( 33 ) found that younger hrs respondents and respondents with more physical function limitations were less likely to consent to the enhanced face - to - face interview and that respondents with diabetes were more likely to consent .
therefore , our estimates of physical function limitations among respondents with prediabetes or normoglycemia are likely conservative estimates .
this study highlights the high prevalence of physical function limitations and comorbidities among middle - aged and older adults with prediabetes .
particularly striking is the high prevalence of difficulty with physical function essential for lifestyle interventions . the findings may help to explain the low rates of physical activity participation among adults despite their knowledge of having prediabetes ( 8) . on the other hand , physician advice can potentially improve physical activity participation ( 34 ) .
our findings suggest that when providing advice on physical activity , health providers should inquire about the patient s physical function limitations and make specific recommendations to accommodate those limitations .
for example , it would be impractical to simply recommend walking 30 min / day to a patient who has chronic knee pain from arthritis .
additional guidance about how to be physically active with a chronic pain condition may be more helpful .
knowledge about physical function limitations among patients with prediabetes will help providers to make tailored physical activity recommendations , to consider referring patients to rehabilitation programs to increase physical activity , or to perhaps recommend pharmacologic therapy for diabetes prevention . in summary , we found a high prevalence of comorbidities and physical function limitations in a nationally representative sample of middle - aged and older adults with prediabetes .
 objectiveto describe the prevalence of physical function limitations among a nationally representative sample of adults with prediabetes.research design and methodswe performed a cross - sectional analysis of 5,991 respondents 53 years of age from the 2006 wave of the health and retirement study . 
 all respondents self - reported physical function limitations and comorbidities ( chronic diseases and geriatric conditions ) . respondents with prediabetes reported no diabetes and had a measured glycosylated hemoglobin ( hba1c ) of 5.76.4% . 
 descriptive analyses and logistic regressions were used to compare respondents with prediabetes versus diabetes ( diabetes history or hba1c 6.5% ) or normoglycemia ( no diabetes history and hba1c < 5.7%).resultstwenty - eight percent of respondents 53 years of age had prediabetes ; 32% had mobility limitations ( walking several blocks and/or climbing a flight of stairs ) ; 56% had lower - extremity limitations ( getting up from a chair and/or stooping , kneeling , or crouching ) ; and 33% had upper - extremity limitations ( pushing or pulling heavy objects and/or lifting > 10 lb ) . 
 respondents with diabetes had the highest prevalence of comorbidities and physical function limitations , followed by those with prediabetes , and then normoglycemia ( p < 0.05 ) . compared with respondents with normoglycemia 
 , respondents with prediabetes had a higher odds of having functional limitations that affected mobility ( odds ratio [ or ] 1.48 ) , the lower extremities ( or 1.35 ) , and the upper extremities ( or 1.37 ) ( all p < 0.01 ) . the higher odds of having lower - extremity limitations remained after adjusting for age , sex , and body mass index ( or 1.21 , p < 0.05).conclusionscomorbidities and physical function limitations are prevalent among middle - aged and older adults with prediabetes . 
 effective lifestyle interventions to prevent diabetes must accommodate physical function limitations . 
RESEARCH DESIGN AND METHODS
Physical measures and biomarkers
Covariates
Physical function
Statistical analysis
RESULTS
CONCLUSIONS