 using targeted exome sequencing we identified mutations in nnt , an antioxidant defence gene , in patients with familial glucocorticoid deficiency . in mice with nnt loss , higher levels of adrenocortical cell apoptosis and impaired glucocorticoid production were observed . 
 nnt knockdown in a human adrenocortical cell line resulted in impaired redox potential and increased ros levels . 
 our results suggest that nnt may have a role in ros detoxification in human adrenal glands . 
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