presence of a solitary symmetrical maxillary central incisor of normal crown dimensions situated precisely in the midline in both primary and permanent dentitions was apparently first reported by scott . since then
, smmci has been reported both as an apparently isolated dental finding and with a variety of midline developmental defects , e.g. holoprosencephaly ( hpe ) , and/or pituitary dysfunction .
various terminologies like  monosuperoincisivodontic dwarfism ,   single central incisor syndrome ,   single maxillary central incisor ,  and  single incisor ,  suggested by other authors,[47 ] do not adequately describe the peculiarly formed incisor tooth .
the smmci differs from normal incisor in that the crown form is symmetric and it develops precisely in midline of maxillary dental arch in both primary and permanent dentitions and is not a supernumerary tooth .
smmci may occur in isolation or in association with other systemic abnormalities like short stature , pituitary insufficiency , microcephaly , choanal atresia , midnasal stenosis , and congenital nasal pyriform aperture stenosis .
it is considered as one of the most minimal expressions ( microforms ) of the hpe spectrum .
deletions on chromosomes 7 and 18 ( at 7q36.1 and 18p- ) , which are in chromosomal regions that harbor hpe genes , have been reported to be associated with smmci.[1013 ] some investigators found sonic hedgehog ( shh)mutation in patients affected by smmci .
hemifacial microsomia ( hfm ) is believed to be the second most common craniofacial anomaly following cleft lip and palate , involving first and second branchial arch derivatives .
an association has been described between hfm and hypodontia . barring a single case report ,
the presence of single maxillary central incisor has not been reported in association with hfm .
this article reports the case of a boy with hfm syndrome who presented with the classical signs of the syndrome and an smmci .
a 6-year - old boy of indian origin attended cleft and craniofacial clinic at oral health science centre , pgimer , chandigarh , with the chief complaint of asymmetry of face .
there was no history of medication during pregnancy and the delivery was atraumatic and full term .
the patient had undergone surgical procedure 1 year after birth for torticollis and had average built and normal mental development . there was no history of nasal malformation or stenosis .
the masseter and temporalis muscles were hypolplastic and mastoid prominence was small [ figure 1 ] .
frontal view of the patient at 6 years showing facial asymmetry , indistinct philtrum and smmci intraoral examination revealed the presence of single deciduous central incisor .
the incisor was placed in midline and had symmetrical right and left contours , which resembled distal contour of central incisors .
the palate had characteristic v shape , with fine bony ridge running along the length .
the arches were narrow in size with the left side more collapsed than the right [ figure 2 ] .
intraoral view showing the presence of smmci ( primary central incisor ) and absence of labial frenum intraoral periapical x - ray views of the patient 's maxillary incisor region confirmed the presence of solitary incisor .
intraoral periapical radiograph confirming the presence of smmci and intermaxillary suture the patient required a multidisiciplinary management and long - term follow - up . in the first phase ,
the patient was reviewed every 6 months and radiographs for regular monitoring of facial growth were done . the facial asymmetry aggravated as the age advanced due to differential growth of right and left sides [ figures 46 ] . at the age of 8 years
, the permanent maxillary central incisor which has the morphology of fused central incisors erupted in midline .
the size of this central incisor was comparable to normal central incisor [ figure 7 ] .
panoramic view showed that the coronoid process , condylar process , and mandibular ramus were hypoplastic on the left side and eruption of teeth was delayed due to lack of space in arch [ figure 8 ] .
extraoral frontal view at 8 years showing exaggerated asymmetry and retarded growth on the left side right lateral view showing normal development left lateral view showing stunted growth intraoral view at 8 years showing smmci ( permanent central incisor ) panoramic radiograph at 8 years of age showing hfm , smmci , and delayed eruption on the left side as a part of dental treatment , maxillary expansion can be commenced in late mixed dentition and the space created after moving smmci to one side of the arch can be replaced by a single tooth implant or crown by a prosthodontist .
genetic counseling is required , as some individuals with smmci , normal intelligence , and normal brain image have had children with hpe and smmci has been recognized as a risk factor for holoprosencephalic offspring .
to the best of our knowledge , this is the second case report in literature in which smmci was found in association with hfm .
the first was reported by garcia de paula e silva et al . in a 10-year - old male patient .
it is likely that a number of mechanisms can give rise to smmci syndrome , some of which may also cause hpe .
hall et al . reported a series of 21 consecutive cases of smmci , the spectrum of anomalies , and associated features present in these cases , and defined smmci syndrome .
smmci can also be a feature of recognized syndromes or associations or a finding in patients with specific chromosomal abnormalities .
reviewed the extensive number of anomalies in addition to hpe with which smmci had been reported .
the correlation has been found with , velocardiofacial ( vcf ) , digeorge syndrome , hpe , ectodermal dysplasia , and duane retraction syndrome , but not with hfm .
the incidence of this condition , also known as oculoauriculovertebral dysplasia , is about 1 in 5000 to 25,000 live births .
the phenotype is highly variable and the features include unilateral deformity of the external ear and small ipsilateral half of the face with epibulbar dermoid and vertebral anomalies .
the ear deformities range from preauricular tags of cartilagenous masses to atresia of the external auditory canal , anomalies in the size and shape of the external auricle , and even anotia .
in addition to the craniofacial anomalies , there may be cardiac , vertebral , and central nervous system defects .
commonly observed malformations include microtia , macrostomia , and failure of formation of mandibular ramus and condyle .
a factor aggravating asymmetry at an earlier age might be torticollis , but due to early release ( within 1 year ) , the effect on growth of face is expected to be minimum .
the smmci may be due to a congenitally missing tooth bud with agenesis of the incisor and the remaining incisor erupts in the midline .
it has been hypothesized that the formation of one instead of two teeth could result from a disturbance in the mitotic potential of the incisor tooth bud , which could be under genetic and environmental determinants .
it has also been proposed that for smmci to form , the dental lamina must have fused prematurely in midline , resulting in apposition and fusion of forming tooth buds .
it has also been suggested that space limitation in maxillary arch or deficiency of lateral growth from midline would result in premature fusion of spreading lamina from the right and left sides . in this patient ,
the solitary incisor might be a result of premature fusion in midline as in hfm there is lack of space in jaws .
although genetic and environmental pathogenic mechanisms have been proposed for hfm , it is likely that the cause is multifactorial . in a review of various pathogenic models ,
several investigators favor a vascular basis for the development of this anomaly.[2731 ] another theory is based on disruption of migration of neural crest cells during craniofacial development.[173234 ] if a disturbance in neural crest cell development or migration plays a role in hfm and hypodontia , it would follow that a correlation between the two conditions should occur .
it is generally accepted that normal odontogenesis requires the presence and interaction of neural crest ectoderm and mesenchymal cells .
disturbances in the odontogenic process can produce abnormal or incomplete dental development . in a previous study
it should be noted that the smmci may occur alone or in other conditions bearing no relationship to hpe .
cohen states that rather than thinking about a single central incisor as a microform of hpe , it is better to think of it as 
 an integral component of severe hpe , an anomaly that occurs alone and in other conditions unrelated to hpe , the only manifestation in some members of a dominantly affected family with variable expressivity of hpe and incomplete penetrance , andrarely as an isolated dominant trait with an shh mutation . 
 
an integral component of severe hpe , an anomaly that occurs alone and in other conditions unrelated to hpe , the only manifestation in some members of a dominantly affected family with variable expressivity of hpe and incomplete penetrance , and rarely as an isolated dominant trait with an shh mutation . in this case
, smmci along with hfm may be considered as an anomaly that has occurred alone and is unrelated to hpe.it is also possible that in patients presenting with hfm , the smmci may be more than a chance finding .
a further critical evaluation of patients with hfm and association between the two might be helpful in providing insight into the unknown etiology of the two conditions .
 solitary median maxillary central incisor ( smmci ) is a rare dental anomaly . 
 it is estimated to occur in 1:50,000 live births . 
 the smmci tooth differs from the normal central incisor in that the crown form is symmetric and it develops and erupts precisely in the midline of the maxillary dental arch in both primary and permanent dentitions . 
 presence of smmci with hemifacial microsomia ( hfm ) is a very rare clinical condition . 
 we report a case of hfm in a male of indian origin who presented with smmci in both primary and permanent dentitions . 
 the association of hfm with smmci may be due to defective development of neural crest cells and/or lack of space in maxilla . 
Introduction
Case Report
Discussion