myocardial bridging is defined as a segment of the major coronary artery running intramurally through the myocardium , deviating from its usual epicardial course.[13 ] myocardial bridging is most commonly seen in the left coronary artery distribution .
the clinical significance of this common congenital condition of the coronary arteries is controversial , with some believing it to be completely benign while others attach a pathological tag to myocardial bridges .
although myocardial bridges are a relatively common congenital condition , it has been believed that the intramyocardial segment of the coronary artery is protected from atherosclerosis compared to the proximal portion of the artery due to variable shear forces of blood flow .
herein , we report an unusual case with a combination of myocardial bridging over the left anterior descending artery with obstructive atherosclerosis in the intramyocardial part .
autopsy was conducted on a 45-year - old male patient who had suddenly collapsed while at work and died before any medical help could arrive .
dissection of the coronary arteries in the heart showed a 2.5-cm ( 25 mm ) long myocardial bridge present over the left anterior descending artery [ figures 1 and 2 ] .
gross examination of the coronaries and aorta showed presence of atherosclerosis in most parts of the arteries .
atherosclerosis was also present in the intramyocardial segment of the left anterior descending artery as well as in the part proximal to it .
microscopic examination revealed thick fibrous cap atheroma being present in the intramyocardial segment , causing significant occlusion [ figure 3 ] .
myocardium supplied by the left anterior descending artery beyond the myocardial bridge showed early changes of infarction such as waviness of fibers and a few neutrophils .
gross photograph showing myocardial bridge over the left anterior descending artery gross photograph showing cut myocardial bridge over the left anterior descending artery microphotograph showing fibrous cap atheroma with cardiac muscle covering the adventitia of the artery ( h and e 100 )
myocardial bridging was first described by reyman in 1737 at autopsy , and since then it has been the topic of much debate regarding its clinical significance .
it has been given various names like  myocardial bridge ,   intramural coronary artery , 
 mural coronary artery ,   coronary artery overbridging  and  myocardial loop . 
the first angiographic description of myocardial bridge in vivo was given by porstmann and iwig in 1960 .
the incidence of myocardial bridges has been reported to vary between 15 and 85% at autopsy and 1.5 and 16% in angiographic series .
this discrepancy might be due to the difficulty of picking up the systolic narrowing in angiography and also due to the inclusion of epicardial artery loops with myocardial bridging in autopsy series .
major part of the blood flow to the cardiac musculature occurs during the diastolic phase .
the myocardial bridge causes coronary artery narrowing during systole and therefore technically speaking , myocardial bridges should not compromise blood supply to the musculature during diastole . various complications like ischemia and acute coronary syndromes , coronary spasm , arrhythmias , exercise - induced atrioventricular conduction block , cardiac stunning and sudden death are known to occur due to myocardial bridging.[1367 ] the study by bourassa et al .
, states that milking effect of the myocardial bridge on the coronary artery extends from systole into diastole , leading to delay in early diastolic diameter gain and also mid - diastolic diameter reduction .
the reduction in the diameter of the coronary artery during diastole can have clinical effects like ischemia when the patient has a rapid heart rate where the diastolic phase is relatively shortened , leading to decreased blood supply to the musculature .
one of the hypothesis states that the systolic kinking may lead to trauma to the endothelial cells and starting off platelet aggregation and vasospasm , resulting in an acute coronary syndrome .
hence , coronary vasospasm of the atherosclerosed arterial segment possibly could have led to the myocardial ischemia and death , as no other cause for sudden death in the patient could be found .
the musculature deriving blood supply from the affected artery showed early changes of myocardial infarction in our case .
the degree of the obstruction caused by the myocardial bridge depends on factors such as location , thickness and length of the muscle bridge .
studies have shown that the intima of the intramyocardial segment is significantly thinner than the proximal segment and that it could be protected by pro - atherosclerotic factors such as shear stress .
histologic studies have shown that the intramyocardial segment consists only of contractile type smooth muscle cells and lacks synthetic type of smooth muscle , explaining the absence of atherosclerosis .
ge et al . , studied 14 cases of which 86% had atherosclerotic lesions , but all of these were located proximal to the bridged segment with no atherosclerotic lesions in the intramyocardial segment .
a few case reports of atherosclerosis occurring in the intramyocardial segment like the one by winter rje et al .
myocardial bridging is a commonly found , mostly benign , anatomic variation found at autopsy or angiographic evaluation .
myocardial bridging should be kept in mind as a differential diagnosis in patients who have angina but do not have the traditional risk factors or in those patients where the angina is induced by strenuous exercise . as seen in this case
, atherosclerosis can occur in the intramyocardial segment of the artery , and this fact should be kept in mind for the effective treatment of the patient .
 myocardial bridging is a congenital coronary anomaly with a variety of clinical manifestations . traditionally , myocardial bridging has been considered a benign condition , but some cases of myocardial ischemia , infarction and sudden cardiac death due to myocardial bridging have been reported . 
 various studies have suggested that in their intramyocardial segments , these vessels are protected from obstructive atherosclerosis , with atherosclerosis being present in the proximal part of the artery . 
 we report a case in a 45-year - old male who had a 2.5-cm long myocardial bridging over the left anterior descending artery , with obstructive atherosclerosis being present in the proximal as well as the intramyocardial part ( part of the artery below the myocardial bridge ) . 
 atherosclerosis occurring in the intramyocardial segment is a rare occurrence , and combined with systolic narrowing by the myocardial bridge can lead to ischemia of the cardiac musculature . 
INTRODUCTION
CASE REPORT
DISCUSSION
CONCLUSION