the loss - of - resistance ( lor ) technique is routinely used to identify the epidural space . the episure autodetect syringe ( eas ) manufactured by indigo orb , inc . ,
santa clara , ca , usa is a new lor syringe with an internal compression spring that applies constant pressure on the plunger [ figure 1 ] .
this obviates the need to apply pressure on plunger , allowing operator to use both hands while continuously advancing the epidural needle .
the plunger automatically depresses when needle enters epidural space , providing an objective , visual confirmation of lor , as opposed to subjective  feel  required with standard lor syringes .
these advantages may help the resident anaesthesiologist to achieve higher success rate in identifying the epidural space .
the components of the syringe are named in an observational pilot study , the use of the device was reported to confer increased success in epidural space identification , primarily with resident anaesthesiologists .
few studies had demonstrated the usefulness of this syringe in identifying lumbar epidural space in labour analgesia , but none of the studies tested this device in thoracic epidural . in this study
, we compared the performance and the success rate of eas , a spring - loaded syringe versus glass syringe ( gs ) when used to identify epidural space using lor technique with saline for lower thoracic epidurals by resident anaesthesiologists .
after ethical committee approval and written informed patient consent , patients aged 1860 years , american society of anesthesiolgists ( asa ) physical status i - ii , who were planned to undergo upper and lower abdominal surgeries and needed post - operative analgesia were enrolled for the study .
exclusion criteria were asa physical status grade 3 or more , history of anticoagulant treatment , abnormal spine , history of neurologic , psychiatric and cardiopulmonary disease , active liver or renal impairment and pregnant women . in this prospective randomised control study , epidural analgesia was performed by resident anaesthesiologists ( who had already performed at least 50 thoracic or lumbar epidurals ) using an 18-gauge tuohy needle in the space between t10-t11 with the standard gs or the spring - loaded syringe in the right lateral position .
the residents performed epidurals using gs , which was alternated with the spring - loaded syringe .
i ( eas ) , epidural space was identified with eas , a spring - loaded syringe and group ii ( gs ) , with gs .
all providers watched a training video about the spring - loaded syringe before study commencement .
the placement of the epidural catheter was performed before the induction of general anaesthesia ( ga ) .
epidural analgesia was initiated using 10 ml of 0.25% bupivacaine with fentanyl 2 g / ml , ga was performed after confirming the success of epidural block . at the end of surgery , epidural
the following variables were recorded : patient demographic data , depth of the epidural space , number of attempts , time to locate the epidural space , and inadvertent dural puncture . in case of accidental dural pucture ,
the failed epidural analgesia was defined as the need to resite the epidural catheter due to failure to obtain sensory blockade after giving an initial loading dose of the local anaesthetic .
the time to locate the epidural space was measured by the attending anaesthesiologist supervising the resident using a stopwatch that was started as soon as the syringe was attached to the tuohy needle ( with the needle tip in interspinous ligament , as per the manufacturer 's recommendation ) , and stopped when the epidural space was identified as indicated by visual inspection of lor . to calculate the required sample size ,
based on the values of difference in mean time to reach epidural space from these observations , minimum sample size required was calculated as 120 cases ( 60 cases in each group ) , with 95% power ( beta error ) .
data analysis was done with the help of computer using epidemiological information package ( epi info 7 ) developed by centre for disease control , atlanta .
using this software , range , frequencies , percentages , means , standard deviations , chi - square , 
t - test was used to test the significance of the difference between quantitative variables and yate 's and fisher 's chi - square tests for qualitative variables .
of 140 patients that were evaluated for the study , 16 patients were excluded according to the exclusion criteria and four patients did not give informed consent ; hence , we randomised 120 patients in two groups of 60 each .
demographic data were similar in both the groups [ table 1 ] and there was no difference in the depth of epidural space between two groups [ figure 2 ] .
in group i , using eas , 55 residents succeeded in identifying the epidural space in the first attempt itself whereas in gs group , 46 residents succeeded in the first attempt [ table 2 ] .
the number of attempts taken to identify the epidural space was significantly lower in group i. the time taken to identify the epidural space was also significantly less in group i ( 31.63  9.4 s ) as compared to group ii ( 39.0  14.3 s [ table 2 and figure 3 ] .
profile of cases studied depth of epidural space efficacy of the two syringes time to reach epidural space there were five cases of inadvertent dural puncture in group ii ( gs ) but no such incidence in group i ( eas ) .
the failed epidural analgesia was reported in five cases , and all happened in gs group ii [ figure 4 ] .
epidural analgesia and anaesthesia are commonly used as a form of pain relief during childbirth , for the treatment of chronic back pain or as a means to provide anaesthesia or analgesia during specific operations .
the failure of epidural analgesia usually results from failure to identify the epidural space correctly . during an epidural insertion , the operator tries to perceive which tissue layer the needle tip is passing through by feeling the resistances on the needle .
a well - known technique referred to as lor essentially involves identification of the epidural space by compression of either fluid or air as the epidural needle encounters the various ligaments of the lumbar vertebral column .
this was first explained in early 20 century and is the most common method used by many anaesthesiologists .
the advantages of this technique are that it is easy to learn , cost effective , and not cumbersome with high sensitivity and specificity .
both air and fluid can be used as a medium for this technique , but the debate is still on as to which medium is superior .
first is historical , as until the 70 's , syringes were made from glass and were non - disposable .
disadvantages of using air are possibility of causing pneumocephalus headache , cervical emphysema , patchy block , and air embolism . with the availability of plastic syringes
fluid gained popularity as a medium as it eliminated most of the problems of air as a medium .
the main disadvantages with the use of saline are dilution of local anaesthetic agent affecting sensory blockade , and confusion with cerebrospinal fluid if accidental dural puncture occurs .
the lor is a subjective feeling , so most of the failure rates occur with inexperienced practitioners .
baraka a reported  saline infusion technique in which the saline from the infusion set enters the epidural space as there is negative pressure in the epidural space .
the main advantage of this technique is that the needle can be gripped by both the hands and also directed according to the needs .
based on this principle , a new spring - loaded autodetect syringe episure was designed by indigo orb , inc . , santa clara , ca , usa . in eas , the constant pressure applied may confer increased success of correct epidural space identification .
visual observation of lor with the spring - loaded syringe removes operator subjectivity and variability ; thus , its use might offer a more precise end - point compared with the standard gs .
it has been suggested that the incidence of dural puncture might be reduced when using lor to saline while applying constant pressure on the plunger . in our study , there were five cases of inadvertent dural puncture in gs .
the incidence of dural puncture was nil with use of spring - loaded syringe ; this might be due to use of lor to saline by applying constant pressure on the plunger . with this technique
, needle advancement is prevented the instant the epidural space is identified , and pressurised saline pushes the dura away from the tip of the tuohy needle as soon as it enters the epidural space . during intermittent needle advancement , there is a risk that even with small incremental advancement ,  overshooting into the subarachnoid space may occur .
the quicker identification of the epidural space with the spring - loaded syringe ( 31.63  9.4 s ) as compared to gs ( 39.0  14.3 s ) might partly be attributed to the difference between using continuous pressure to advance the needle in the spring - loaded syringe group compared with intermittent advancement by some providers in the gs group .
this finding is similar to that of habib et al . , who noted that the median elapsed time with the spring - loaded syringe versus a conventional gs was 20 s ( 1128 s ) and 40 s ( 2558 s ) respectively ( p < 0.001 ) with epidural analgesia in parturient .
the impact of the spring - loaded syringe on the establishment of successful epidural labour analgesia ( primary outcome ) , elapsed time for catheter placement , and learning curve ( cumulative summary analysis , i.e. cusum ) of experienced anaesthesiologists were assessed in a study .
it was concluded that with experienced obstetric anaesthesiologists , the spring - loaded syringe is associated with a similar success rate for establishing successful epidural labour analgesia , a more rapid elapsed time to epidural catheter insertion , and a similar cusum curve when compared with a conventional gs .
most of the residents ( 55/60 ) were able to identify the epidural space in the first attempt itself using this spring - loaded syringe .
the overall successful epidural analgesia in spring - loaded syringe is attributed to both hands - free technique , constant pressure on plunger and visual observation of lor .
previous studies demonstrated the success of spring - loaded syringe in lumbar epidural for labour analgesia , but in our study done in lower thoracic epidurals for abdominal surgeries are equally efficient and successful even though the thickness of ligamentum flavum is thinner in thoracic epidural space .
the problems encountered by our residents initially were difficulty in holding the spring - loaded syringe with saline in one hand that was overcome later after the subsequent experience .
some residents preferred to have a locking mechanism on the spring - loaded syringe to prevent expulsion of saline before its attachment to the tuohy needle .
this also prevented the saline loss during any detachment or withdrawal into the subcutaneous tissue to redirect the needle . a locking mechanism ( three - way adapter with locking ) for redirection would be a good addition especially for difficult epidural placement in obese patients .
though this study demonstrated statistically significant difference between the two syringes in the time to identify the epidural space , a difference of 810 s did nt give much advantage of eas over gs .
future studies are required to determine if the spring - loaded syringe leads to similar reduction in accidental dural punctures and reduces the time to enter epidural space by experienced anaesthesiologists .
the spring - loaded syringe provides an opportunity to use both hands and hence the residents had better control over the needle advancement and success rate improved when compared to the gs .
in addition , with eas , residents had both subjective and objective confirmation of epidural space by the depression of the plunger .
this objective confirmation of epidural space prevented the overshooting and thereby accidental dural puncture by the residents .
 background and aims : episure autodetect syringe ( eas ) , a spring - loaded syringe , is a new loss - of - resistance syringe used to identify epidural space . 
 it has an advantage of subjective and objective confirmation in identifying epidural space over glass syringe ( gs ) for beginners . we compared the performance of eas with that of gs for identifying epidural space in lower thoracic epidurals.methods:a total of 120 american society of anesthesiolgists i 
 - ii patients aged 1860 years requiring lower thoracic epidural analgesia for surgery were randomised into group i ( eas ) : epidural identified using eas and group ii ( gs ) epidural identified with gs . 
 patient demographic data , depth to epidural space ( cm ) , number of attempts , time to locate epidural space ( s ) , inadvertent dural puncture and failed epidural analgesia were the parameters noted.results:there were no differences in patient demographics or depth to the epidural space between the two groups . 
 there were five failed blocks in the gs group and none in the eas group ( p = 0.0287 ) . 
 similarly , there were five inadvertent dural punctures in the gs group and none in the eas group ( p = 0.0287 ) . when epidural was identified in fewer attempts , the time needed to identify epidural space was quicker with eas ( p = 0.0012).conclusion : using eas allowed reliable and quick identification of the epidural space in lower thoracic epidural technique as compared to use of glass syringe . 
 there was no incidence of inadvertent dural puncture or failed blocks with the eas . 
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONCLUSION