Does using Izanagi require the Mangekyo Sharingan? Does using Izanagi require the Mangekyo Sharingan? I'm asking this question because on other questions, people are saying that the Izanagi and Izanami does not require the Mangekyo Sharingan, but rather, Senju and Uchiha DNA, plus a Sharingan. However, it is seen that many people used Izanagi without Senju and Uchiha DNA, as well as no Mangekyo Sharingan, but,

Black Zetsu's statement contradicts that entire argument.
So does using Izanagi really require a Mangekyo Sharingan? Or was this just a mistake?
NO, just like what you said, they only need a Senju DNA and a Uchiha DNA, plus a Sharingan which means genetic traits of the Sage of the Six Paths. The Uchiha, descended from the Sage, are able to perform Izanagi with their Sharingan.
You could check HERE about Izanagi.
For Madara case, his Sharingan already upgraded to another level. So he have to use his MS(Mangekyo Sharingan) for the activation. But still, MS is from Sharingan. I see no error here.
However, could you list out who used Izanagi without about these condition?

However, it is seen that many people used Izanagi without Senju and Uchiha DNA, as well as no Mangekyo Sharingan