Do the regions in Soul Eater match perfectly to the real world? The Death Sycthes' manage real world regions as like a replacement to Death's Eight Guardians, they are. 


Spirit Albarn - North America 
Marie Mjolnir - Oceania 
Azusa Yumi - Eastern Asia 
Justin Law - Western Europe 
Tezca Tlipoca - South America 
Tsar Pushka - Eastern Europe 
Deng Dinga and Djinn Galland - Africa and Western Asia (How Wikipedia list them, not sure which is which)


I am wondering if these region are the same as the regions in our world? if so would that make Death City be located in North America?
Yes, it is related to the real world. There's no map ever shown, but Death City is a fictional city set in Nevada, USA.


  Shibusen is an academy located in the fictional Death City, of Nevada where Meisters and Weapons attend.


Source: Soul Eater wiki: Shibusen

Also, it's not listed, but I'm quite sure (judging by appearance) that Deng Dinga is from Africa, and Djinn Galland is from Western Asia.