Are the peculiar One Piece laughs based on anything? In One Piece, there are several strange laughs such as 


Donquixote Doflamingo with his Fuffuffuffuffu
Dorry with his Gegyagyagyagya 


Are laughs like these based on anything? Or are they just randomly chosen for comedic purposes ?
In One Piece, the laughters are very unique and can be based on personalities or appearances of the said characters. 

By giving them different laughs, IMO, gives a sense of their aura and keeps the character entertaining.