Who were the first and second persons to use Mangekyou Sharingan? In episode 132 of Naruto, in the middle of the fight between Naruto and Sasuke, there is a flashback in which Itachi asks Sasuke to obtain Mangekyou Sharingan, and if he is able to obtain it, he will be the third guy to use it.

Who were the first and second persons, as both of his father and Tobi had Mangekyou Sharingan and he himself was using Mangekyou Sharingan?
The first one is Obito, then known as Madara Uchiha.
The second one is Shisui Uchiha, a very good friend of Itachi. Shisui gave one of his eyes to Itachi, the other one was stolen by Danzo.