MacOS: iTunes switches to safe mode occasionally Once a week or so, this message pops up on my Macbook Pro:

why?  When I restart iTunes, iTunes seems happy again (for a time).
Safe mode is (usually) triggered by holding  Cmd ⌘  &amp;  Opt ⌥  as you launch iTunes. It's a diagnostic mode for troubleshooting.
I can't imagine why it would do this alone, unless you have stuck keys… but you'd have very probably noticed that by now.