Should I disable Virtual Memory on SSD in OS X Yosemite? Should I, or do I need to, disable memory swapping when my OS is installed on an SSD? I run OSX 10.10.2 with 16GB of memory. Currently, Activity Monitor reports I have 16GB of virtual memory allocated, with 0Bytes actually being used. 5,28GB of Memory is in use.

I understand that it's beneficial for the longevity of as SSD to reduce the amount of write-actions to it, which leads me to believe it's also beneficial to not have a swap-file on that drive. If I really need one, can I move it to my internal HDD? If so: how?
For how to do that, I recommend this excellent sophisticated answer: How can I move virtual memory swap files to a different drive or partition?

But keep in mind that your SSD does NOT wear out as bad as most youngsters tell you. In fact, I experience HDs breaking a lot more often than SSDs. Besides, your computer only swaps if it's really necessary as it comes with enormous memory access speed penalties. And even if it was: I'd prefer keeping the swap on the SSD rather than moving it to a slow HD. 

But always keep in mind: Storage media are expendable parts.