Noise canceling headphones make strange sound when I touch my MacBook Pro I've got headphones plugged into my desktop, and a laptop nearby that I use for work as well.  Whenever I touch my MacBook Pro with the noise-canceling on my headphones turned on, it makes my headphones go nuts, creating a lot of buzzing, crackling, and popping.

I assume this has something to do with conduction between my hands and the computer, but is there any way to get around this?
It appears your wall socket is not properly grounded, which may cause electrical interference on your headphones when touching the MacBook Pro.

Have a look at this related answer on possible measures you can take to establish a proper electrical grounding.