How to set permanent default applications on El Capitan Every time I restart my mac book pro, all my settings of default applications change to factory default applications. For eg, I set adobe acrobat reader DC as my default PDF viewer, sublime text as default text editor and google chrome as default browser but on next restart/power on, the default applications change back to preview, textedit and safari.

How can I make my changes permanent and prevent this change from happening?

Right now, for setting default apps, I right click on file -> Get Info -> Open With -> Change All
But this has to be done on every power on/restart.
Never face this, but I would say to delete the 
/users//library/preferences/com.apple.launchservices.plist file
where  is your username

Then, define a preferred app for your PDFs, shutdown, restart and check