Application Support directory, some apps are using tons of space! After running out of space multiple times, I started researching and putting a strategy to permanently fix this issue.

In the end I found that Application Support is an important directory for most of apps, but I've a directory called Google with 2.2 GB size. Most probably this is for Chrome only. What does this directory include and what will happen if I delete it?

Including information about directories and their sizes:
It appears to be local storage, used by websites to store temporary files. This article explains how you can use Chrome itself to inspect the contents in more detail.

Seems like it should be safe enough to delete (the article also describes a Chrome extension that can safely do that), but as always, make sure you have a backup just in case.