Can I have different virtual desktops with different resolutions/scaling? I'm really frustrated by the way some applications are not HiDPI aware and resort to pixel doubling - video games, GIMP, etc.

Is it possible to have one of my virtual desktops (I think apple uses a different term? "Workspaces"?) be at the native resolution (ie "scaled" to "more space") while the other remain at "best for this display"?

I've done a tonne of searching and I can't find anything, but maybe it's just hurt by the fact I don't know the apple jargon.

I'd be happy with something like windows has that allows me to turn off DPI scaling for specific applications. 

I have a 2014 Macbook Pro 15" retina with a 2880x1800 resolution.

Thank you for any help :)
No, each Desktop (Space) will have the same resolution, whatever the Display's resolution is set at.

You could use an App like Display Menu to more easily/quickly change the resolution as needed/wanted as you change between Desktops.