How to prevent Option+Command+Space from opening "Searching This Mac"? The following keyboard shortcut will always bring up a window that says Searching "This Mac":

Option+Command+Space

I would like to use this shortcut for another purpose.  Is there any way to disable this shortcut?
Yes. Go to System Preferences → Spotlight and uncheck the box for the Spotlight window keyboard shortcut. Alternatively, replace the shortcut with a different shortcut.



You can also enable/disable/modify the shortcut through System Preferences → Keyboard → Spotlight → Show Spotlight Window: