Setup wireless iPad - iTunes connection without connecting via USB first? If a user plugs in an iPad into the USB port of a computer which is running iTunes, iTunes recognises iPad, and allows the user to manage apps or media files on the iPad from iTunes. 

I know iTunes allows users to do that wirelessly (meaning that the iPad is not connected to the USB port of the computer running iTunes) if the iPad and the computer are connected to the same Wi-Fi network, but it seems that one must first connect the iPad to the computer at least once to make the iTunes recognise the iPad. 

Is there any way to set up the wireless connection between an iPad and an iTunes (computer) without the initial USB connection?
No, they have to the 'paired' via USB first.