Big Sur - unresponsive dialogs to mouse actions Sometimes at the beginning of 2021, I started to have a problem with the &quot;File upload&quot; dialogs in the web browser. The dialog is unresponsive to the mouse. I can use the keyboard for navigation, but the Tab key only switches between the left panel and the &quot;Search&quot; field and I'm unable to focus the main area with files. Thus I'm unable to select a file, but I can escape that dialog with Esc and, as this regards also &quot;Save as&quot; dialogs, I'm able to select some directory in left panel's &quot;Favorites&quot; and confirm with Enter.
As time passes, I realized, that this problem applies to almost all native dialogs. I'm currently unable to open e.g. Pages or TextEdit, as it starts with the &quot;File open&quot; dialog, which I'm unable to handle.
And yesterday, I needed to tweak some configuration in &quot;Security &amp; Privacy&quot; in &quot;System Preferences&quot; and I realized it has the same symptoms. I can click on the top navigation panel and return back to the &quot;System Preferences&quot; main screen, but I'm unable to click on anything in the &quot;Security &amp; Privacy&quot; main section. The keyboard navigation works, but, again, the Tab key only switches between the left list and the &quot;Search&quot; field, and I'm unable to click on &quot;Click the lock to make changes&quot; so, it's all helpless.
I Googled for similar issues, but so far found nothing heplful.
Does anyone have some idea where to look, what to try?
So I tested it in the &quot;Safe mode&quot; and no problem. After I restarted to normal mode, the problem is also gone ‍♂️
Strange, I know I have quite a long uptime, but I installed an update to macOS 11.2.2 last week and the problem survived the installation of the update and restart.
Hope it will never return