Does adding Yosemite Tags to a File change its MD5 Signature? I have a cloud backup system that relies on MD5 hash signatures for de-duplication.

Does adding OSX tags to a file change its MD5 hash?

EDIT: I did some testing and got mixed results depending on the filetype/app used. So not sure if the tag itself is making a difference or something else change by the app.
I ran md5 file in Terminal.app, applied a tag to file, and re-ran md5. The hash returned was the same. Without knowing your exact setup it's impossible to know for sure, but it looks like you're OK.