Fixing Night Shift incompatibility with external monitors If you use an external monitor for your Mac of any shape or size and recently updated to macOS Sierra 10.12.4, chances are you've had some trouble with Night Shift. 

Common issues include:


the inability to configure Night Shift from your external monitor
Night Shift being impossible to disable (as a result of the former)
a substantial loss of colour quality (as a result of both of the former happening at once on some connection or screen types, most commonly DVI-D to VGA, DisplayPort, and LCD screens of all kinds.)


How do you get past these issues? Is there a way to enable access to the Night Shift pane on any display?
Unplug the cable and insert it again.

It works for me.

Update for Catalina (macOS 10.15): For secondary monitors, you may have to unplug primary monitor, so that the secondary monitor is the primary monitor. (Doing this once should be enough)

by @Michael_Scharf