Is there a way to tweet from a keyboard command? I use CMD space a million times a day to find files, launch apps, etc.

Wouldn't it be cool if I could press a keyboard combination and get a box to send a tweet?  I know I can do it through notification center but I'm looking for a method that doesn't require me to leave the keyboard.
The official Twitter app lets you define a shortcut in its settings (Global new tweet):


As far as native Twitter integration goes, I really don't know :)