Adobe CS5 Mac iOS High Sierra 10.13.6 Just stopped working! Help My Gear:
iMac (Retina 5K, 27-inch, Late 2015)
Processor: 3.2 GHz Intel Core i5
Memory: 16 GB 1867 MHz DDR3
Graphics Card: AMD Radeon R9 M380 2048 MB

iOS: High Sierra 10.13.6

Preferences: The programs that are problematic are enabled. Only Photoshop works.

Problem:
I have been running CS5 for quite a few years now, relatively trouble free other than some minor quirks.

Primarily, I use Photoshop, Illustrator, Acrobat Pro, InDesign.

Yesterday, everything but Photoshop all suddenly came to a crashing halt.  Cannot start up the programs again.  A long time ago, I turned off all auto updates. 

What changed? 
Why, out of the blue, would all these Adobe programs just stop working?

Any help is greatly appreciated.
After paying $1800 at the time for Adobe Creative Suite CS5, I too have no desire to go to a cloud based &quot;pay for play&quot; software, especially during these uncertain financial times.
Have you tried having two hard drives which contain two different operating systems on them?
I have Mac OS 10.8.5 on one hard drive so that I can used Steinberg's Cubase version 6, and I have MAC OS 10.13.6 Hign Sierra on a my main hard drive - I just switch to my &quot;downgrade&quot; hard drive and keep working...and you can access both drives from the menu like normal.
That was my saving grace!  I can still use Photoshop on 10.13.6, but it won't let me run Adobe Premiere CS5.
Sadly, in all my Mac years no one ever told me I could do that.  It would've saved me a lot of upgrade money when a new OS didn't work with my audio software (especially WAVES plugins which I paid lots of money for and it became obsolete, since WAVES too is on a cloud-based-pay-to-play model)
Hope this helps.