Best way to run WINE on OS X? What is it?

(I know, oh so subjective.)

So let's make that, what's the most effective and pain free way to do it? I realize those may be contradictory conditions.
The easiest and most pain free way is to use homebrew

https://github.com/mxcl/homebrew

Once you follow the instructions to install homebrew on this page (which include installing Xcode), you can then simply type 

brew install wine


And this will download and compile wine and all its dependendencies.