Is it safe to delete ~/Library/Caches? Is it safe to delete the file Caches, in the Library of the Mac OS X Hard Drive?

It's a pretty big file, 3.56 GB, Caches reminds me of logs i don't need or browser cookies. 

Is it safe to delete the folder "Caches"?
It's generally safe, though a little dangerous depending, to do it but often not worth the effort.

The caches in /System/Library/Caches are generally small and useful, the ones in /Library/Caches are less system caches and much more readily cleared.

If you have a look in ~/Library/Caches you will find a bunch of applications have a cache in there, none of them particularly large though dropbox sometimes has a fair sized cache. This folder can run quite large just because so many apps cache something in there.

If the cache /Library/Caches folder is over 3Gb then you have something that is caching quite a lot. On the three machines I just checked none had a /Library/Caches folder over .75 Gb so I'd go right ahead and remove some of it.

Don't worry about age, I'd worry about size.

In the terminal run the following to sort all of the files in that directory by size (ascending):

du -s /Library/Caches/* | sort -h


Of course the best way to clear the caches is to install AppleJack and do it with that in single user mode. Doing it with the System fully up can be a little dangerous. If you do it then I'd reboot immediately afterwards.