Middle mouse button stops working from time to time I have a very strange problem, and it started since I got my LG 5K Ultrafine screen and started using an external keyboard and mouse.

I usually notice it in Blender, so it might be related to that.

I use the middle mouse button to rotate the view in Blender, and suddenly it acts as if I'm holding down the mouse button, even if I'm not, and when I move the mouse the view rotates.

Now if I switch to a browser, like Chrome, the middle mouse button doesn't work. I can't close tabs for example, which usually works.

Using the track pad, I can triple finger click, and it works as it should.

I have a couple of mouse controlling apps, to make it work like I'm used to from PC, and it might be causing these issues.


Smart scroll (to controll scroll speed in different apps)
USB overdrive (to disable the horrible acceleration)
Logitech control center (which only works when a Logitech mouse is in)


I just tried switching to a Logitech mouse, and it has the same issues as the other mouse, which is a Corsair (which doesn't have Mac drivers, but it usually just works)

Suddenly it just starts working again, and also a reboot helps, but it's so annoying since it happens like once every 30 minutes or so.

So it's a weird problem, and I'd be happy to know if anyone has had anything similar?
USB Overdrive was the culprit, and I found that it happened when I held the scroll wheel clicked and scrolled at the same time. By disabling/enabling USB Overdrive, it started to work again.

However, when I disable the setting "Wheel button: Middle button", this stopped happening, and the middle mouse button works as it should.