Google Chrome confirm close Many a time and oft I get confused between close tab (⌘+w) and close (⌘+q) in Google Chrome, closing dozens of tabs at once.

How do I specify a close prompt before closing multiple tabs on Chrome (version 18.0.1025.168)? 

I have tried chrome://flags/, and the wrench menues but found no such option.
Enabling "Warn Before Quitting" should prevent that from happening. You can find that option in the Chrome menu in the menubar.

When enabled, you need to hold down ⌘+Q for a bit before it actually quits.