Can I delete files and folders in /private/var/tmp folder? I ran into the situation where using simultaneously Google Drive File Stream (DFS) and Code42 Crashplan and some other Corporate SW like CrowdStrike's Falcon, Bitdefender, etc... which seems are not liking each other (see this article).
Anyway, there turned up two issues:

one which was manageable in user accessible space (DFS cache was ~60GB)
the other beyond standard user access, where in /private/var/tmp folder occupied 210+GB

Resolving issue #1 was relatively &quot;trivial&quot; still not sure how to go around it in the future.
Resolving issue #2 took me several days of investigation and trials.
The solution now, seems quite straight forward possible to achieve in 5 or 6 main steps.
Not to repeat myself here again, I'd rather post link to Apple forum where I post similar question: How to safely delete a content of /private/var/tmp