Is it possible to reduce memory usage by iTunes 11 on Mac? I have iTunes 11.0.1 running on Mac OS 10.8.2 with quite a large music library, some podcasts and my iPhone connected. According to Activity Monitor, the iTunes process is taking 1.6 GB real memory, and 4.26 GB virtual. How can this be? Of 16 GB in my machine, I have 60MB free. Is it automatically grabbing all free memory? 

Does anyone know any tricks for reducing this and/or making iTunes less greedy?
If your iTunes is using this much memory, something is wrong.

Just how large your library is? My 700 GB audio + video library takes far less than 500 MB of physical RAM and I actually have my virtual memory disabled.

I will suggest you do the following,

a) Quit iTunes more often.

b) For testing, create a new clean library and monitor the memory usage

c) For testing, reinstall iTunes

Good luck. If you have any more question, comment below!