Faster way to close OS X Windows with only a mouse In applications that open a lot of windows, the most common thing I do with a window (aside from scrolling it) is closing one window. The little red dot in the upper-left corner of a window is the obvious way to close it, but that little dot requires careful (aka slower) mousing to hit it, especially when compared to a browser tab, dock icon, or other frequently-clicked areas that are much larger.

Can I make the little red "window close" button larger?  If not, is there some other mouse-only way to close a window that is easier to target with a fast mouse?

I know I can switch over to the keyboard and use ⌘ Command W to close the window, but I'm a lefty mouse user so I'd have to move my hand off the mouse to hit this key combo, and then move my hand back to the mouse again to continue working. Given that this mouse->close window->mouse sequence is an action I do 100+ times per day, I was hoping to have a faster way to do it.

I'm currently using an old USB mouse with a wheel and two buttons.
If you are using Magic Mouse - there's BetterTouchTool where you can set custom gestures. 
For example you can assign ⌘+w to three fingers click globally. Here's how this looks like:



You can also assign actions to "Normal Mice" if it has additional keys.