Does the iPad setup wizard require a home button in iOS 10? I'm about to factory reset an iPad with a broken home button. I've been using AssistiveTouch in place of the button.  In iOS 10, unlocking requires the home button, so I have to use AssistiveTouch every time I turn the iPad on. My question is—if I factory reset it, is there a part of the iOS 10 setup screen that requires the home button to proceed? If I reset, AssistiveTouch will not be enabled and I won't be able to enable it until the iPad is finished being set up. This could make the device unusable.
The first thing you have to do is unlock the device, which requires you to press the home button.

A thread on Apple Support Communities has a possible workaround, but I can't verify it:


  Once you download iOS10 and get to "Hello" screen, connect your iPhone to iTunes. Under iPhone>Summary page, there is an icon that says "configure accesibility".  Click on it and a window pops up, and enable "Speak auto-text" under "seeing" and "mono-audit" under hearing.  I THINK it should work with just choosing one or the other or any other options for those with seeing/hearing problems.  Click on done, and you see your vertual home button is back on "Hello" screen.


https://discussions.apple.com/thread/7667716