Time Machine on High Sierra failure I have tried a lot of things but I keep getting failed backups when doing a first backup on High Sierra. I have not used Time Machine previously and I am trying to backup to a usb drive. 

Checking the logs after a failure I get something like: 

Last failure: 

 (TimeMachine) [com.apple.TimeMachine:TMLogError] Error: (-50) SrcErr:NO Copying /Volumes/com.apple.TimeMachine.localsnapshots/Backups.backup‌​db/&lt;NAME OF MY COMPUTER&gt;/2017-12-29-105925/Macintosh HD/usr/local/texlive/2015/texmf-dist/tex/latex/seminar/semin‌​ar.cls to /Volumes/Backup/Backups.backupdb/&lt;NAME OF MY COMPUTER&gt;/2017-12-29-105925.inProgress/15E91B0A-F367-4968-A9‌​48-04FF05E7404A/Maci‌​ntosh HD/usr/local/texlive/2015/texmf-dist/tex/latex/seminar 


The errors are always Error (-50) SrcErr:NO Copying and it is always some file from /usr/local (or /usr/) that fails. Could this have to do anything with permissions? I previously had Homebrew installed (which modifies the permissions for some of the subfolders of /usr/local/) and I also have Tex-Live 2016 installed. 

Any suggestions on how to fix this would be greatly appreciated as I am pulling my hair out on this one.
Turns out that it was the hard drive that was the problem. Changing to another drive solved my problem. 

Perhaps Error (-50) is an indication that the drive is failing? I am not sure, but I will leave this here in case someone else runs into the same problem. 

Edit: I ran some diagnostics and the SMART test fails so it was definitely the disk.