Shortcuts failing constantly I am using Adobe Audition. I have defined a few shortcuts for functions I use the most. These shortcuts work sometimes, sometimes don't.

This is also true for shortcuts I have defined for other applications.

When these shortcuts fail, I click on the menu where their respective functions are and then if I try the shortcuts again they work but seconds later they fail again.

Is there a way to make they always work?
That would happen if you set up Shortcuts to work in "All Applications"

Try setting them Application Specific.

Example 





Alternately monitor the com.apple.systempreferences.plist

located in ~/Library/Preferences and sort by date, to see if it changes without your interaction.