Is it possible to enable OSX keyboard text substitution in more apps? OSX has built into text substitution that is configured in System Preferences > Keyboard > Text. This works great in certain apps, such as Evernote and Textedit, but seems to be disabled in other apps/content areas. Is it possible to enable it in other apps, such as Google Chrome?

I would like to use text substitution to drop in signatures when composing emails at gmail.com while using Google Chrome.
The application needs to implement Auto Text Expansion and it hasn't been implemented in Chrome yet. You could try this Chrome plugin Auto Text Expander. You'll have to again add the text-expansions though.

Mac's Text expansion should work in Safari though. If not already enabled, you can enable by typing the following in terminal.

defaults write -g WebAutomaticTextReplacementEnabled -bool true