Homebrew / link osxfuse not possible I didn't run brew doctor since a lot of time. Know it tell me I should run brew link osxfuse. Here I show you the rest:

Newton:~$ brew link --overwrite osxfuse
Warning: Could not link osxfuse. Unlinking...
Linking /usr/local/Cellar/osxfuse/2.6.2... 
Error: Permission denied - /usr/local/include/osxfuse/fuse.h

When I run it with sudo, it says it is better that I shouldn't do it. So I didn't try.
Here is the permission.

Newton:~$ ls -l /usr/local/include/osxfuse/fuse.h
-rw-r--r--  1 root  wheel  246 17 Dez  2011 /usr/local/include/osxfuse/fuse.h

What can I do?
It seems to work if you change the permissions of the parent directory /usr/local/include/osxfuse

You need to ensure that your user has write permissions to this directory and all of it's files.  This should work:

sudo chown USERNAME /usr/local/include/osxfuse
sudo chgrp GROUPNAME /usr/local/include/osxfuse
sudo chmod o+w /usr/local/include/osxfuse