"Application opened for the first time" warning after every reboot I have a problem with Lion 10.7.5.: the system does not remember that I already opened applications before. After every reboot, every time I open an application it displays the warning as if it's the first time I'm opening it. After various tests I think the culprit is lsregister. Anyone knows how to solve this problem? Or as an alternative, anyone knows if there is a plist file that can be edited manually to tell the system that the application has already been opened?

Thanks in advance for your help.
It sounds like there is a permissions error somewhere. Run Disk Utility (from the /Applications/Utilities folder), select your boot drive and click on the "Repair Disk Permissions" button. I usually keep pressing the buttons until there are no errors left. Reboot and try running one of your problem apps. It may warn you again, but after that it should remember that you have run it before.

Good Luck.