Single-purpose app to prevent .DS_Store creation under Mavericks Asepsis is currently not working under Mavericks. It's, in my knowledge, the only single-purpose app existing for this job. Therefore, what is the less intrusive solution to prevent .DS_Store creation after the update to Mavericks?
Asepsis updates have been officially released for Mavericks compatibility - http://asepsis.binaryage.com/

I've personally tested it, working like a charm!