Set Spotify as the source for song titles instead of iTunes A lot of applications say something to the effect of "get the current song title from iTunes for your status", so is there any way to have those pull from Spotify instead of iTunes?

I'm willing to jump through a few hoops, and I'm a software developer so I don't mind some hacks, but I would love to be able to have those apps pull from my Spotify playlist instead of iTunes (who even downloads music anymore? Savages! :p )
What application are you interested in exactly?

One workaround could be to make Spotify scrobble to Last.fm (in preferences), and then get the song title from Last.fm. Iirc, there is a plugin for Adium that does this. Caveat: there'll be some delay in the updates when using this method.