Distilling small volume I have 50 ml of a compound I would like to purify. Since the impurities presents have close boiling points (b.p.), I have to use fractional distillation. Am I going to lose significant quantity of my product volume because of loss related to the distillation itself?

If so, what can I do to minimize the loss?

I thought about adding a higher b.p. solvent to the distillation flask so I can distill all the compound without leaving some in the flask. What do think about this method?

Are there any other strategies?
In order to both achieve sufficient separation and minimize loss during fractional distillation, you want 


a large inner column surface for optimal contact of the vapour phase (upstream) and the liquid phase (downstream)
a rather small inner column volume


Often, these destillation are performed using a Spaltrohr distillation apparatus. Here, the vertical column consists of two concentrical, threaded glas tubes with a gap of 1-2 mm  in between.