Molecular knots absolute configuration How is the absolute configuration of chiral molecular knots determined? What rules should be applied? For centrochiral compounds, the CIP rules are applied, for axially chiral is described here and for planar chiral here. I can't find the system for assigning R/S (or possibly some other stereodescriptors) for molecular knots, e.g  the attached knot doesn't contain an Sn improper axis, therefore it is chiral.
I guess that the IUPAC Gold Book rules for helicity apply here.


  The chirality of a helical, propeller or screw-shaped molecular entity. A right-handed helix is described as P (or plus), a left-handed one as M (or minus).


The above knotane is right-handed, so it should be P.

For more complex molecular knots such simple rules most likely will fail.