What are some of the simplest chiral molecules in biological systems I have understood generally for a while there is a significant preference in "life" for so-called "left-handed" (chiral) molecules, though I'm reading things now that say "life" sugars are right-handed, while "life" amino-acids are left-handed. 

I'm wondering: how simple do these molecules get (particularly the molecules that are in intelligent life, if there happen to be any that are exclusive to intelligent life)?
Don't get hung up on the "left-handed" and "right-handed" designations for amino acids and sugars. Those are just conventions for distinguishing one mirror image (enantiomer) of a chiral molecule from another. It just so happens that based on a particular way of drawing (Fisher projection) amino acids and sugars that it appears that the configurations are "left-handed" or "right-handed."

As for how simple chiral biological molecules get, the simplest ones that I can think of are alanine or lactic acid. I'm not sure what you consider "intelligent", but these are likely to be found in all life (as we know it).