What is the physics of the 'phenomena' of Nirvana? Although a lot has been said and written on the internet about Nirvana, the physics behind it seems to be an obscure and elusive area. 

Human experience seems to be summed up in five-skandhas, dependent origination and six-sense bases.Existence of all of them seems to be physically provable. I want an answer based on such arguments for an e.g. interaction of skandhas etc.  

Nibbana is also said to be 'unconditioned' phenomena, all that is made of Matter or contains Matter is 'conditioned'. If it is nothingness or emptiness, what is the underlying Physics?

Physics has not yet arrived at the definition and exact phenomena of Consciousness. It is called the hard problem of Consciousness. As of now, it has not been explained in terms of physical interaction or as an emergent phenomenon. Consciousness is the only thing that seems to transmute in Nirvana. I have long held the belief that 'Consciousness conscious of itself is Nirvana.

A blind, deaf, mute, senseless, touchless, everyone can get Nirvana but someone without consciousness cannot get Nirvana, that person is essentially dead. After Nirvana the person remains conscious, so what is it that essentially transmutes? 

I am asking, what's the physics?

I am aware this is kind of a question that the Buddha discouraged to ask for e.g. in the Parable of Poisoned Arrow, but still, I have to ask.
In the case of the human mind (or any kind of mind), we're not talking as much about physics as about cognitive functions and the capacity for interpretation.

Chemistry emerges from Physics and physical phenomena; Biology emerges from chemistry; cognitive functions emerge from biology; language emerge from cognitive function; society emerge from language, and so on. Can we explain society just from laws of physics? The more complex are the new emergent processes, the less useful is to use "basic" laws to explain such new complex phenomena. 

"Mind" is a term we use to describe and group all the processes that allow us to build interpretations about the world from sense-data, in orden to make some sense from it and to adapt to the ever changing world.

Emotions and mind-states in general are habitual responses that arise from how the mind has learnt to react under determined circumstances. And those reactions come from the nature of the interpretation built previously in the mind.

We have learnt to control and arrange in specific ways the conditions of the world in order to receive and specific kind of sense-data; namely, that which we perceive as desirable. Also, the opposite is true: we want to put away any part of the sense-data that might be perceived as undesirable.

The Buddhist Path is a gradual training for elininating cognitive ignorance and wrong interpretations about the world and reality, in order to eradicate the habitual emotional and mind-states reactions that lead to insatisfaction and suffering.

Nibbana is the state where, to be at peace, there's no need for an specific set of sense-data information. No matter what enters through the sense-doors, emotions and mind-states will no give rise to insatisfaction, because there's no need to arrange and control the world and the input of sense-data that comes from it. In other words, craving for sense-data and craving for specific states of the idea of the self are uprooted. Nibbana is peace without conditions.

Kind regards!