Can I use a Center Lock hub and disc brake rotor in place of an ISO hub? I currently have a regular ISO disc brake hub and rotor on my front wheel. I'd like to replace it with a Shimano generator hub, but all Shimano hubs use Center Lock rotors instead of ISO. The Center Lock to ISO adapters seem really hokey, so I was thinking I could just get a new Center Lock rotor of the same size.

I don't know how to tell if the left-to-right alignment of the rotors is the same between the two mounting standards. Will this work without any additional adapters or modifications?
Yes, this should work just fine. CenterLock and ISO six bolt wheels should be interchangeable w/o problems as long as they use the same rotor diameter.