Can you change your skewer frame into to thru axle one? I have a frame that uses QR skewers.  Can I modify the frame to use thru axles?Has anyone done it??
Frame rear dropouts and forks for through-axles are of a substantially different design than those designed for quick-release hubs. Through axles are essentially a large bolt that attaches the wheel to the frame whereas quick releases (and older threaded axles clamp the hub into slots.

Most frames and forks cannot be easily modified, the dropouts are permanently attached. Steel or aluminum frames or forks could be cut and new dropouts welded in, but this of course would be difficult and expensive, especially as through axle dropouts have to be aligned much more precisely than quick release ones. Carbon fiber composite frames I suppose could be cut and new dropouts bonded in, but this would likely be more expensive than modifying a metal frame.

Forks can of course be easily replaced. some manufacturers offer frames have removable rear dropouts that can be swapped for through-axle, quick release other style dropouts.