Has there ever been a fully automated takeoff, cruise, and landing of a large aircraft similar to commercial airliners? Has there ever been a fully automated takeoff, cruise, and landing of a large aircraft similar to commercial airliners?

In fact, has there ever been a fully automatic flight of any pure aircraft whatsoever? This is gonna sound crazy, but the only thing I know that comes close is the Soviet Space Shuttle Buran. It launched unmanned and returned successfully under computer control, including its glide and landing.

So I'm interested in automatic aircraft similar to large commercial airlines. BTW, remote control toy planes wouldn't count because that is not automated (a person is manually controlling it).
The book The Glass Cage describes a fully autopilot-controlled military test flight in 1947. The plane was a C-54 Skymaster with seven men aboard. According to this source, the pilot aligned the plane on the runway for takeoff, but the takeoff, course control, and landing were performed by autopilot with no human engagement. See also this report from the Chicago Tribune at the time.