Is there a good reason why modern airliners can't have conventional landing gears (vs. tricycle landing gears)? By "good reason", I mean a reason that we definitely cannot overcome with reasonable changes in aircraft design, control laws or procedures.

As possible benefits of this I see a much smaller (= lighter) tail landing-gear than the nose landing-gear. Also, an opportunity to reduce tail-strike margins (=increase incidence, reduce landing speed). And of course there is all that space at the front of the fuselage that is freed for other uses (systems, cargo, stairs,...?)

One drawback is of course passenger comfort. But passengers already experience high pitch angles during climb, and we could imagine to have the tail of the aircraft raised up (on a stand?) for boarding/deboarding. Also the APU has be moved (but I don't think this is impossible).
Short answer: Yes. Not one, but several. A taildragger configuration for modern airliners comes with several disadvantages:


Visibility during taxiing is much worse.



Visibility while taxiing is a safety-relevant issue (Picture source)


Braking hard will result in a headstand. And with today's landing speeds, braking hard is needed if you want to fly from standard length runways. Carrier-borne aircraft were the first to feel this consequence of increasing landing speeds, so they converted first to tricycle gears.



That is what is colloquially called a "headstand" (Picture source)


Loading and unloading will become more complicated. The current way of sliding containers manually on a flat deck would need to be replaced by internal winches pulling the containers up the ramp to the door.
Drag during ground roll is much higher as long as tail lift is not sufficient to get the tail up. Take-off distances would also become longer.


In short, it comes down to minimizing field lengths and increasing safety.



Who says there are no taildragger airliners? (Picture source)