How has CAD influenced aircraft design in the last few decades? I know that computer aided design was used extensively when designing the Boeing 777, are there any other good examples of aircraft where CAD was essential in the design process?

Are there any major leaps forward in aircraft technology that would have been impossible without CAD?
We used CATIA extensively in the design of the F-22.  It helped all the supporting "ilities" also in their tasks.  Great tool.