Grandmother recently diagnosed with RRMS having bad experience with Aubagio. Curious about potential efficacy of alternatives. My grandmother was recently diagnosed and prescribed Aubagio. Basically, it makes her feel like crap.  So she asked me to look into alternative treatments.  It occurred to me that there may be some overlap between MS research and nootropics research.  The potential for Lions Mane mushroom for treatment of MS is my first suspect due to its ability to stimulate levels of nerve growth factor.  But I'm certainly curious about all relevant information on this topic. So, have there been any reputable studies looking into nootropic-like treatments for MS?