Advice on increasing dosage? I'm almost 5 months on HRT, the last 3 of which have been 50mg cypro and 6mg estradiol daily, taken orally. Overall I've never felt better, and physical changes are happening at a rate I'm happy with. 

After my most recent blood test, my doctor commented that while my levels were good (testosterone 0.8 L, estradiol 327 H), my E level was on the low side. He said that the level itself is irrelevant as long as I'm feeling good and experiencing results, but floated the option of going up to 8mg daily with my next prescription.

Is there any benefit to going on a higher dose given I'm happy with how things currently are? Would there be potential downsides?