When doing exercises on piano, what is the fundamental reason why some arpeggios are more difficult than others?

Here is an example of extremely hard arpeggio (if using the fingering 1, 2, 4): A major, first inversion
[![enter image description here](https://i.stack.imgur.com/ilVIN.png)](https://i.stack.imgur.com/ilVIN.png)

I could not go faster than 95 for a quarter.

Here is an example of a difficult but much more easy : F sharp

[![enter image description here](https://i.stack.imgur.com/QoAOo.png)](https://i.stack.imgur.com/QoAOo.png)

I could play this one at 160 for a quarter with difficulty, when I'm in a very good shape.