What are the best bang-for-buck methods for multiplying ores? For early game, (doubling/tripling) and for late game, (quad/quintupling) what is the most efficient/fastest method to multiply ores?

Side question: Is it possible to multiply ore beyond quintupling? I haven't seen any other mod go as high as mekanism does with ore quintupling, but i was curious if there was a way to go beyond 5x multiplication.