The team struggles with the news that Warehouse 13 will be moving to a new host country.
Pete and Myka capture Paracelsus but not before he makes himself immortal. When Myka's cancer becomes worse, Pete must make a deal with Paracelsus to cure his partner. Meanwhile, Claudia receives some startling news from Artie.
The team have no time to mourn a fallen comrade as they go after the person responsible, the nemesis that has been stalking Artie since he used Magellan's Astrolabe to save the world.
Pete, Myka, and Claudia set off to rescue their loved ones when Brother Adrian sends them deadly artifacts. Meanwhile, Mrs. Frederic and Steve travel to Rome and learn Adrian's dark secret.
Sally Stukowski and her partner make their move, attacking the Regents and using an artifact to trap them in a building and bring it down around them.
The agents track down a cache of artifacts stolen from Warehouse 12 by the infamous Roaring Dan Seavey... and guarded by his ghost. Meanwhile, Charlotte Dupres makes her move with the help of her inside person.
When Mrs. Frederic is stricken ill, the agents must search for a cure before it's too late. Their quest takes them to Egypt and the long-lost Warehouse 2.
Pete, Myka, and Charlotte must track down Sutton, the only man who knows where they can find Paracelsus and exchange the Philosopher's Stone for the stele that will free Claudia from her bronze imprisonment... before she disintegrates.
After Myka leaves the warehouse, Pete gets a new partner: ATF agent Steven Jinks, who has a gift for sensing when someone is lying. Pete and Steven take on a new case in Denver, while Artie, Claudia, and Leena deal with a deadly pair of statues at Warehouse 13.
The team discovers that MacPherson is auctioning artifacts he has siphoned from the Warehouse shelves.
While Claudia and Steve attempt to infiltrate a Civil War reenactment to recover U.S. Grant's flask, Pete and Myka must deal with Pete's ex-wife... who has been stung by an artifact bee that has turned her into a human queen bee.
Holiday Special: Pete is hit in the head by an artifact and wakes up to a life where he was never born. Pete must hunt down and persuade the Warehouse team (none of whom recognize him) to go on this life or death mission with him to vanquish a long dead nemesis from the past to get everyone’s lives back.
H.G. has created a new life for herself in Wisconsin, but calls in the agents when she comes up against an unidentified artifact. Meanwhile, Abigail joins the others on the floor of the Warehouse to track down the source of mysterious tremors that threaten to destroy the building.
The Warehouse team struggles with the horrible reality of the Warehouse's destruction and the tragic loss of Steve Jinks, Mrs. Frederic and H. G. Wells. With matters so desperate, Pete, Myka, Artie, Leena and Claudia must decide whether to knowingly use a dangerous artifact for their own personal gain — at the risk of deadly consequences.
While Pete and Claudia help Hugo Miller track down a bag of marbles at a boy's academy, Myka and Steve travel to New Orleans on the trail of another artifact while Artie meets with Brother Adrian.
Pete and Myka face a curious executive from a drug company as they deal with a pill that may increase people's height. Meanwhile, Artie, Steve and Claudia follow Brother Adrian to the place where he's hiding.
While in Denver, Myka picks up the trail of the counterfeiter who killed her former partner, Sam Martino. Meanwhile, Artie, Claudia, and Steve interrogate a dog that witnessed the theft of an artifact.
While Pete and Myka go to Toronto to investigate an invulnerable hockey player, Steve helps Artie track down stolen artifacts while Claudia meets with Mrs. Frederic to discuss her future as a Warehouse guardian.
Valda tries to move the warehouse to China and use Claudia's comatose sister as a puppet caretaker.
While Pete and his mother Jane try to determine the origins of their mysterious opponents, Myka and Claudia travel to Portland to stop a girl who can apparently vaporize anyone she hates with blasts of radiation.