Four very different African-American women share adventures, advice and an exclusive brownstone in New York City as they hilariously celebrate Living Single. Khadijah (Queen Latifah), is a go-getting entrepreneur with her own magazine. Her cousin Synclaire (Kim Coles) moved from the Midwestern suburbs of Minneapolis and Kadijah's childhood friend and roommate Regine (Kim Fields) often has her head in the clouds, but her sharp-tongue keeps her feet on the ground. Adding to the mix is Khadijah's college classmate and best friend, Maxine (Erika Alexander).
In season four, Overton finally proposes marriage to Synclaire, and Khadijah sells 25% of the magazine to save her business. Max explores other relationships, but is ultimately drawn back to Kyle. Regine encounters romantic problems with her longtime boyfriend, and Overton and Synclaire finally get married.