Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.
Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
Direct visualization of newly synthesized target proteins in situ.
Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses.
Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression.
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging.
On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
We use anisomycin to increrase p38 MAPK activity, though it can also be used to block protein synthesis.