Jack Corbin is an American gunfighter hired to come to Sangre De Cristo to bring in a family of murderers dead or alive. However everything is turned upside down when he learns the family he is hired to hunt down are actually vampires and that he is completely outclassed and outgunned. With the help of an Indian medicine man he learns to drink the blood of the one vampire he has killed and become fast enough in the daytime to take a vampire. The downside is his body will become addicted to vampire blood and rapidly and painfully die if he does not keep hunting vampires. A mysterious young Asian woman hovers around all of this as she waits to see the outcome. She is the 650 year old Iron Lotus who has been hunting vampires for the Catholic church since the mid 1200s. She too drinks vampire blood to kill vampires and this has stopped her own aging process. She too now requires their blood to survive. She is a master in martial arts and though quite attractive is also incredibly deadly. If Jack can prove himself with these vampires here the Catholic church will want her to team up with him to hunt more vampires. What our heroes do not know is the Church is just using them until they have eradicated vampires and then will hunt Jack and Iron Lotus down as they are now considered part demonic themselves. The vampires all have a human that drinks their blood and then protects the vampires in the daylight. These blood drinkers are called 'halflings' and must be battled through to get to the vampires. Our heroes can not hope to beat a vampire at night and must hide in safe places such as churches when night falls then hunt again in the daylight hours. Even then their edge is only slight and the danger is always intense. Because the heroes do not age this show can move forward in time for some episodes to one of the episodes we already have written takes place in modern times where we follow a particularly unsavory vampire who hunts down his teenage girl victims using social media.