Evidence-based clinical management in pediatric nephrology is a challenging and major goal of our Society. Indeed, most diseases pediatric nephrologists deal with are severe rare diseases requiring optimal management in the face of a limited number of randomized clinical trials. To this end, IPNA has successfully begun a new initiative in 2018 with the aim of developing “IPNA Clinical Practice Recommendations (IPNA-CPR)”, addressing important global topics in the field of pediatric nephrology. The first IPNA CPR Workshop on steroid-resistant nephrotic syndrome took place in Leuven, Belgium on Dec 13 & 14, 2018. This IPNA-CPR is currently on the way to finalization and publication in Pediatric Nephrology.