debase was invalid. (Exception from HRESULT: 0x80131047).
Run a repair on BizTalk?
360 suggests running lodctr /r as a last resort, any risks involved?
The first thing to try is a Repair of the BizTalk installation.
Then reapplication of the latest CU you have installed.
Try to check and see if there are missing dependencies.
Also check BAM databases and credentials that is running under.
Also check tracking host instance and credentials since BAM data is moving under tracking host as well. So you may rerun BizTalk configuration and recheck the settings.