Conclusions
Fragile X premutation is a risk for movement disorders and cognitive dysfunction and it should be considered in patients with a family history of mental retardation or autism, and particularly in those females with premature ovarian failure.
Neurological signs in the adult with fragile-X premutation
 
  Keywords
 
 
  
   Fragile X permutation
  
 
 
  
   Tremor/ataxia syndrome
  
 
 
  
   Parkinsonism
  
 
 
  
   Cognitive deficit
  
 
Abstract
 Introduction
Fragile X syndrome is an inherited form of <dis>mental retardation</dis>.
It results from an abnormally expanded number of trinucleotide CGG repeats.
Some grandfathers of these children become forgetful, have frequent falls and other neurological problems.
Researchers have found a connection between fragile X syndrome and the neurological symptoms in elderly men.
This resulted in the recognition of a syndrome originally referred to as “intention tremor, parkinsonism and generalised brain atrophy in carriers of a fragile X premutation”.
This premutation is also associated with premature ovarian failure.
Methodology
This paper reviews the literature on the neurological signs of fragile X premutation.
Conclusions
Fragile X premutation is a risk for <dis>movement disorders</dis> and <dis>cognitive dysfunction</dis> and it should be considered in patients with a family history of <dis>mental retardation</dis> or <dis>autism</dis>, and particularly in those females with premature ovarian failure.
Abstract
 Introduction
Fragile X syndrome is an inherited form of mental retardation.
It results from an abnormally expanded number of trinucleotide CGG repeats.
Some grandfathers of these children become forgetful, have frequent falls and other neurological problems.
Researchers have found a connection between fragile X syndrome and the neurological symptoms in elderly men.
This resulted in the recognition of a syndrome originally referred to as “intention tremor, parkinsonism and generalised brain atrophy in carriers of a fragile X premutation”.
This premutation is also associated with premature ovarian failure.
Methodology
This paper reviews the literature on the neurological signs of fragile X premutation.
Conclusions
Fragile X premutation is a risk for movement disorders and cognitive dysfunction and it should be considered in patients with a family history of mental retardation or autism, and particularly in those females with premature ovarian failure.
Conclusions
Fragile X premutation is a risk for <dis>movement disorders</dis> and <dis>cognitive dysfunction</dis> and it should be considered in patients with a family history of <dis>mental retardation</dis> or <dis>autism</dis>, and particularly in those females with premature ovarian failure.
movement disorders
DISABILITY
cognitive dysfunction
DISABILITY
mental retardation
DISABILITY
autism
DISABILITY