Results
The impact of sequencing the human genome in the knowledge of genome architecture, DNA variability and the significance of structural variations in the sequence to cause diseases is presented. The evolution of sequencing technology has determined the design and performance of genetic association studies. Finally, we present genetic association studies performed in common causes of ear diseases.
Role of genomic medicine in middle and inner ear diseases
 
  Keywords
 
 
  
   Chronic otitis media
  
 
 
  
   Otosclerosis
  
 
 
  
   Age-related hearing loss
  
 
 
  
   Meniere's disease
  
 
 
  
   DNA variability
  
 
 
  
   Genome-association studies
  
 
Abstract
 Introduction and objectives
Genomic medicine investigates groups of genetic markers that determine susceptibility for complex diseases.
The aim of this review was to introduce genomics to the clinical otorhinolaryngologist.
Technological advances in genotyping and sequencing that have facilitated genome-wide association studies in common causes of <dis>hearing loss</dis> during the last years are summarised.
Methods
A search strategy in _PubMed_ was designed using the following keywords: (gene OR genomics OR GWAS OR high throughput) AND (hearing loss OR chronic otitis media OR age-related hearing loss OR otosclerosis OR Meniere's disease) during the last 5 years.
A total of 1,846 references were obtained.
After filtering by human studies and English as the language of publication, 1,295 summaries were evaluated, selecting 58 papers.
Results
The impact of sequencing the human genome in the knowledge of genome architecture, DNA variability and the significance of structural variations in the sequence to cause diseases is presented.
The evolution of sequencing technology has determined the design and performance of genetic association studies.
Finally, we present genetic association studies performed in common causes of ear diseases.
Abstract
 Introduction and objectives
Genomic medicine investigates groups of genetic markers that determine susceptibility for complex diseases.
The aim of this review was to introduce genomics to the clinical otorhinolaryngologist.
Technological advances in genotyping and sequencing that have facilitated genome-wide association studies in common causes of hearing loss during the last years are summarised.
Methods
A search strategy in _PubMed_ was designed using the following keywords: (gene OR genomics OR GWAS OR high throughput) AND (hearing loss OR chronic otitis media OR age-related hearing loss OR otosclerosis OR Meniere's disease) during the last 5 years.
A total of 1,846 references were obtained.
After filtering by human studies and English as the language of publication, 1,295 summaries were evaluated, selecting 58 papers.
Results
The impact of sequencing the human genome in the knowledge of genome architecture, DNA variability and the significance of structural variations in the sequence to cause diseases is presented.
The evolution of sequencing technology has determined the design and performance of genetic association studies.
Finally, we present genetic association studies performed in common causes of ear diseases.
Results
The impact of sequencing the human genome in the knowledge of genome architecture, DNA variability and the significance of structural variations in the sequence to cause diseases is presented. The evolution of sequencing technology has determined the design and performance of genetic association studies. Finally, we present genetic association studies performed in common causes of ear diseases.