Abstract
 We show two atypical Cogan’s syndrome cases in forty-seven and fifty-six years old individuals. Characteristical symptoms of the syndrome were detected in both (interstitial keratitis, sensorineural deafness and vestibular dysfunction), but they could be considered as unusual because of the association of sistematic symptoms and an onset with hearing loss.
Atypical cogan’s syndrome. Clinical features and laboratory findings. report of two cases
 
  Key words
 
 
  
   Cogan’s syndrome
  
 
 
  
   Autoimmune disease
  
 
 
  
   Western-blot
  
 
 
  
   Immunodiagnosis
  
 
Abstract
 We show two atypical Cogan’s syndrome cases in forty-seven and fifty-six years old individuals.
Characteristical symptoms of the syndrome were detected in both (interstitial keratitis, <dis>sensorineural deafness</dis> and vestibular dysfunction), but they could be considered as unusual because of the association of sistematic symptoms and an onset with <dis>hearing loss</dis>.
In both cases there was an increase in erythrosedimentation rate and immunoglobulins leveles, as well as high titles for rheumatoid factor and non-specific autoantibodies.
By means of a Western-blot technique, several choclear antibodies with distinct molecular weight were detected, but the 68 KD appeared in both.
Metil-prednisolone treatmen did not avoid ocular and auditive reactivation in ne of the patients.
Abstract
 We show two atypical Cogan’s syndrome cases in forty-seven and fifty-six years old individuals.
Characteristical symptoms of the syndrome were detected in both (interstitial keratitis, sensorineural deafness and vestibular dysfunction), but they could be considered as unusual because of the association of sistematic symptoms and an onset with hearing loss.
In both cases there was an increase in erythrosedimentation rate and immunoglobulins leveles, as well as high titles for rheumatoid factor and non-specific autoantibodies.
By means of a Western-blot technique, several choclear antibodies with distinct molecular weight were detected, but the 68 KD appeared in both.
Metil-prednisolone treatmen did not avoid ocular and auditive reactivation in ne of the patients.
Abstract
 We show two atypical Cogan’s syndrome cases in forty-seven and fifty-six years old individuals. Characteristical symptoms of the syndrome were detected in both (interstitial keratitis, <dis>sensorineural deafness</dis> and vestibular dysfunction), but they could be considered as unusual because of the association of sistematic symptoms and an onset with <dis>hearing loss</dis>.
sensorineural deafness
DISABILITY
hearing loss
DISABILITY