NOECs and LOECs are determined by hypothesis testing ( Dunnett 's Test , a t test with the Bonferroni adjustment , Steel 's Many-one Rank Test , or the Wilcoxon Rank Sum Test with the Bonferroni adjustment ) , whereas LCs , ICs , and ECs are determined by point estimation techniques ( Probit Analysis , Spearman-Karber Method , Trimmed Spearman-Karber Method , Graphical Method or Linear Interpolation Method ) .
Hypothesis testing is how LOECs are calculated .