Is there a role for TFII-I in megakaryopoiesis?
Yes. TFII-I acts as a repressor of β-globin gene transcription and is implicated in the differentiation of erythrocytes into megakaryopoiesis.  Mutations in exon 2 interfere with the synthesis of the full-length isoform of TF II-I and lead to the production of a shortened isoform, TFII, in erythroid cells. TF2-I has a role in embryonic development and differentiation of all eukaryotes but its physiological function is still unclear.