Oxycodone/paracetamol
Oxycodone/paracetamol, sold under the brand name Percocet among others, is a combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.
In 2019, it was the 59th most commonly prescribed medication in the United States, with more than 11 million prescriptions.

History
The United States Food and Drug Administration (FDA) first approved Percocet in 1976, under application ANDA 085106.

Implicated in deaths
On June 30, 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.In March 2017, U.S. President Donald Trump initiated the Opioid and Drug Abuse Commission.
In July 2017, an interim report was published. Some excerpts:

References
External links
"Acetaminophen mixture with Oxycodone". Drug Information Portal. U.S. National Library of Medicine.
"Prescription Acetaminophen Products to be Limited to 325 mg Per Dosage Unit; Boxed Warning Will Highlight Potential for Severe Liver Failure". U.S. Food and Drug Administration. 13 January 2011.
"FDA warns about several safety issues with opioid pain medicines; requires label changes". U.S. Food and Drug Administration. 22 March 2016.
"FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines; requires its strongest warning". U.S. Food and Drug Administration. 31 August 2016.