Hsieh, C.S., Macatonia, S.E., Tripp, C.S., Wolf, S.F., O’Garra, A., and Murphy, K.M.: Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993, 260:547–549.
Muñoz-Fernández, M.A., Fernández, M.A., and Fresno, M.: Synergism between tumor necrosis factor-α and interferon-γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur. J. Immunol. 1992, 22:301–307.
Murray, P.J., and Wynn, T.A.: Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 2011, 11:723–737.
Stout, R.D., Suttles, J., Xu, J., Grewal, I.S., and Flavell, R.A.: Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J. Immunol. 1996, 156:8–11.
11-6 Activation of macrophages by TH1 cells must be tightly regulated to avoid tissue damage.
Duffield, J.S.: The inflammatory macrophage: a story of Jekyll and Hyde. Clin. Sci. 2003, 104:27–38.
Labow, R.S., Meek, E., and Santerre, J.P.: Model systems to assess the destructive potential of human neutrophils and monocyte-derived macrophages during the acute and chronic phases of inflammation. J. Biomed. Mater. Res. 2001, 54:189–197.
Wigginton, J.E., and Kirschner, D.: A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis. J. Immunol. 2001, 166:1951–1967.
11-7 Chronic activation of macrophages by TH1 cells mediates the formation of granulomas to contain intracellular pathogens that cannot be cleared.
James, D.G.: A clinicopathological classification of granulomatous disorders. Postgrad. Med. J. 2000, 76:457–465.
11-8 Defects in type 1 immunity reveal its important role in the elimination of intracellular pathogens.
Berberich, C., Ramirez-Pineda, J.R., Hambrecht, C., Alber, G., Skeiky, Y.A., and Moll, H.: Dendritic cell (DC)-based protection against an intracellular pathogen is dependent upon DC-derived IL-12 and can be induced by molecularly defined antigens. J. Immunol. 2003, 170:3171–3179.
Biedermann,T., Zimmermann, S., Himmelrich, H., Gumy,A., Egeter, O., Sakrauski, A.K., Seegmuller, I., Voigt, H., Launois, P., Levine, A.D., et al.: IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat. Immunol. 2001, 2:1054–1060.