Posterior duodenal ulcers erode either directly onto the gastroduodenal artery or, more commonly, onto the posterior superior pancreaticoduodenal artery, which can produce torrential hemorrhage, which may be fatal in some patients. Treatment may involve extensive upper abdominal surgery with ligation of the vessels or by endovascular means whereby the radiologist may place a very fine catheter retrogradely from the femoral artery into the celiac artery. The common hepatic artery and the gastroduodenal artery are cannulated and the bleeding area may be blocked using small coils, which stem the flow of blood.
Anterior duodenal ulcers erode into the peritoneal cavity, causing peritonitis. This intense inflammatory reaction and the local ileus promote adhesion of the greater omentum, which attempts to seal off the perforation. The stomach and duodenum usually contain considerable amounts of gas, which enters the peritoneal cavity and can be observed on a chest radiograph of an erect patient as subdiaphragmatic gas. In most instances, treatment for the ulcer perforation is surgical.
In the clinic
Examination of the upper and lower
It is often necessary to examine the esophagus, stomach, duodenum, proximal jejunum, and colon for disease. After taking an appropriate history and examining the patient, most physicians arrange a series of simple blood tests to look for bleeding, inflammation, and tumors. The next steps in the investigation assess the three components of any loop of bowel, namely, the lumen, the wall, and masses extrinsic to the bowel, which may compress or erode into it.
Examination of the bowel lumen
Barium sulfate solutions may be swallowed by the patient and can be visualized using an X-ray fluoroscopy unit. The lumen can be examined for masses (e.g., polyps and tumors) and peristaltic waves can be assessed. Patients may also be given carbon dioxide–releasing granules to fill the stomach so that the barium thinly coats the mucosa, resulting in images displaying fine mucosal detail. These tests are relatively simple and can be used to image the esophagus, stomach, duodenum, and small bowel. For imaging the large bowel, a barium enema can be used to introduce barium sulfate into the colon. Colonoscopy and CT colonography are also used.
Examination of the bowel wall and extrinsic masses
Endoscopy is a minimally invasive diagnostic medical procedure that can be used to assess the interior surfaces of an organ by inserting a tube into the body. The instrument is typically made of a flexible plastic material through which a light source and eyepiece are attached at one end. The images are then projected to a monitor. Some systems allow passage of small instruments through the main bore of the endoscope to obtain biopsies and to also undertake small procedures (e.g., the removal of polyps).
In gastrointestinal and abdominal medicine an endoscope is used to assess the esophagus, stomach, duodenum, and proximal small bowel (Figs. 4.72 to 4.75). The tube is swallowed by the patient under light sedation and is extremely well tolerated.
Assessment of the colon (colonoscopy) is performed by passage of the long flexible tube through the anus and into the rectum. The endoscope is then advanced into the colon to the cecum and sometimes to the terminal ileum. The patient undergoes bowel preparation before the examination to allow good visualization of the entire large bowel. Specially designed solutions are taken orally to help clear the bowel of fecal material. Air, water, and suction may be used during the examination to improve visualization. Biopsies, polyp removal, cauterization of bleeding, and stent placement can also be performed using additional instruments that can be passed through special openings in the colonoscope.