Sakaguchi, S., Yamaguchi, T., Nomura, T., and Ono, M.: Regulatory T cells and immune tolerance. Cell 2008, 133:775–787.
Saraiva, M., and O’Garra, A.: The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 2010, 10:170–181.
9-24 Effector T-cell interactions with target cells are initiated by antigen-nonspecific cell-adhesion molecules.
Dustin, M.L.: T-cell activation through immunological synapses and kinases. Immunol. Rev. 2008, 221:77–89.
van der Merwe, P.A., and Davis, S.J.: Molecular interactions mediating T cell antigen recognition. Annu. Rev. Immunol. 2003, 21:659–684.
targets to regulate signaling and to direct the release of effector molecules.
Bossi, G., Trambas, C., Booth, S., Clark, R., Stinchcombe, J., and Griffiths, G.M.: The secretory synapse: the secrets of a serial killer. Immunol. Rev. 2002, 189:152–160.
Montoya, M.C., Sancho, D., Vicente-Manzanares, M., and Sanchez-Madrid, F.: Cell adhesion and polarity during immune interactions. Immunol. Rev. 2002, 186:68–82.
Trambas, C.M., and Griffiths, G.M.: Delivering the kiss of death. Nat. Immunol. 2003, 4:399–403.
9-26 The effector functions of T cells are determined by the array of effector molecules that they produce. & 9-27 Cytokines can act locally or at a distance.
Basler, C.F., and Garcia-Sastre, A.: Viruses and the type I interferon antiviral system: induction and evasion. Int. Rev. Immunol. 2002, 21:305–337.
Boulay, J.L., O’Shea, J.J., and Paul, W.E.: Molecular phylogeny within type I cytokines and their cognate receptors. Immunity 2003, 19:159–163.
Guidotti, L.G., and Chisari, F.V.: Cytokine-mediated control of viral infections. Virology 2000, 273:221–227.
Harty, J.T., Tvinnereim, A.R., and White, D.W.: CD8+ T cell effector mechanisms in resistance to infection. Annu. Rev. Immunol. 2000, 18:275–308.
Proudfoot, A.E.: Chemokine receptors: multifaceted therapeutic targets. Nat. Rev. Immunol. 2002, 2:106–115.
9-28 T cells express several TNF-family cytokines as trimeric proteins that are usually associated with the cell surface.
Bekker, L.G., Freeman, S., Murray, P.J., Ryffel, B., and Kaplan, G.: TNF-alpha controls intracellular mycobacterial growth by both inducible nitric oxide synthase-dependent and inducible nitric oxide synthase-independent pathways. J. Immunol. 2001, 166:6728–6734.
Hehlgans, T., and Mannel, D.N.: The TNF–TNF receptor system. Biol. Chem. 2002, 383:1581–1585.