Matsumoto, R., Wang, D., Blonska, M., Li, H., Kobayashi, M., Pappu, B., Chen, Y., Wang, D., and Lin, X.: Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NFκB activation. Immunity 2005, 23:575–585.
Rueda, D., and Thome, M.: Phosphorylation of CARMA1: the link(Er) to NFκB activation. Immunity 2005, 23:551–553.
Sommer, K., Guo, B., Pomerantz, J.L., Bandaranayake, A.D., Moreno-García, M.E., Ovechkina, Y.L., and Rawlings, D.J.: Phosphorylation of the CARMA1 linker controls NFκB activation. Immunity 2005, 23:561–574.
Thome, M., and Weil, R.: Post-translational modifications regulate distinct functions of CARMA1 and BCL10. Trends Immunol. 2007, 28:281–288.
7-17 PI 3-kinase activation upregulates cellular metabolic pathways via the serine/threonine kinase Akt.
Gamper, C.J., and Powell, J.D.: All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells. Front. Immunol. 2012, 3:312.
Kane, L.P., and Weiss, A.: The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol. Rev. 2003, 192:7–20.
Pearce, E.L.: Metabolism in T cell activation and differentiation. Curr. Opin. Immunol. 2010, 22:314–320.
7-18 T-cell receptor signaling leads to enhanced integrin-mediated cell adhesion.
Bezman, N., and Koretzky, G.A.: Compartmentalization of ITAM and integrin signaling by adapter molecules. Immunol. Rev. 2007, 218:9–28.
Mor, A., Dustin, M.L., and Philips, M.R.: Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol. Rev. 2007, 218:114–125.
7-19 T-cell receptor signaling induces cytoskeletal reorganization by activating the small GTPase Cdc42.
Burkhardt, J.K., Carrizosa, E., and Shaffer, M.H.: The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 2008, 26:233–259.
Tybulewicz, V.L.J., and Henderson, R.B.: Rho family GTPases and their regulators in lymphocytes. Nat. Rev. Immunol. 2009, 9:630–644.
7-20 The logic of B-cell receptor signaling is similar to that of T-cell receptor signaling, but some of the signaling components are specific to B cells.
Cambier, J.C., Pleiman, C.M., and Clark, M.R.: Signal transduction by the B cell antigen receptor and its coreceptors. Annu. Rev. Immunol. 1994, 12:457–486.