Abney, E.R., Cooper, M.D., Kearney, J.F., Lawton, A.R., and Parkhouse, R.M.: Sequential expression of immunoglobulin on developing mouse B lymphocytes: a systematic survey that suggests a model for the generation of immunoglobulin isotype diversity. J. Immunol. 1978, 120:2041–2049.
Blattner, F.R., and Tucker, P.W.: The molecular biology of immunoglobulin D. Nature 1984, 307:417–422.
Enders, A., Short, A., Miosge, L.A., Bergmann, H., Sontani, Y., Bertram, E.M., Whittle, B., Balakishnan, B., Yoshida, K., Sjollema, G., et al.: Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. Proc. Natl Acad. Sci. USA 2014, 111:4513–4518.
Goding, J.W., Scott, D.W., and Layton, J.E.: Genetics, cellular expression and function of IgD and IgM receptors. Immunol. Rev. 1977, 37:152–186.
5-15 Transmembrane and secreted forms of immunoglobulin are generated from alternative heavy-chain mRNA transcripts.
Early, P., Rogers, J., Davis, M., Calame, K., Bond, M., Wall, R., and Hood, L.: Two mRNAs can be produced from a single immunoglobulin μgene by alternative RNA processing pathways. Cell 1980, 20:313–319.
Martincic, K., Alkan, S.A., Cheatle, A., Borghesi, L., and Milcarek, C.: Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nat. Immunol. 2009, 10:1102–1109.
Peterson, M.L., Gimmi, E.R., and Perry, R.P.: The developmentally regulated shift from membrane to secreted μ mRNA production is accompanied by an increase in cleavage-polyadenylation efficiency but no measurable change in splicing efficiency. Mol. Cell. Biol. 1991, 11:2324–2327.
Rogers, J., Early, P., Carter, C., Calame, K., Bond, M., Hood, L., and Wall, R.: Two mRNAs with different 3ʹ ends encode membrane-bound and secreted forms of immunoglobulin μchain. Cell 1980, 20:303–312.
Takagaki, Y., and Manley, J.L.: Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. Mol. Cell. 1998, 2:761–771.
Takagaki, Y., Seipelt, R.L., Peterson, M.L., and Manley, J.L.: The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain premRNA during B cell differentiation. Cell 1996, 87:941–952.
5-16 IgM and IgA can form polymers by interacting with the J chain.