Lymphocytes circulate through both lymphatic and blood vessels.
The circulation of lymphocytes through the lymphatic vessels and the bloodstream enables them to move from one part of
TABLE Characteristics of Interleukins14.3 Interleukin 12 IL-12 T cells Stimulates growth of NK cells, CD4T cells, and CD8T cells Interleukin 13 IL-13 T cells Modulates B-cell responses and promotes IgE synthesis Interleukin 14 IL-14 T cells, follicular dendritic cells Induces production of memory B cells Interleukin 15 IL-15 T cells, monocytes Induces proliferation and differentiation of CD8T cells Interleukin 16 IL-16 T cells Activates migration of CD8T cells, mono-cytes, and eosinophils Interleukin 17 IL-17 Memory CD4T cells Stimulates endothelial cells and fibroblasts to secrete cytokines Name Symbol Source Major Functions Interleukin 1 IL-1 Neutrophils, monocytes, macrophages, endothelial cells Stimulates various cells in inflammatory response Induces fever Facilitates proliferation of CD4T cells and proliferation and differentiation of B cells Interleukin 2 IL-2 CD4T cells Induces proliferation and differentiation of CD4T cells and to a lesser degree CD8T cells, B cells, and NK cells Interleukin 3 IL-3 CD4T cells Induces proliferation of hematopoietic stem cells Interleukin 4 IL-4 CD4T cells, mast cells Induces proliferation and differentiation of B cells, CD4T cells Activates macrophages Promotes synthesis of IgE and IgG Interleukin 5 IL-5 CD4T cells Induces proliferation and differentiation of eosinophils Stimulates B cells to secrete IgA Interleukin 6 IL-6 Endothelial cells, neutrophils, macrophages, T cells Stimulates differentiation of hematopoietic cells Induces growth of activated B cells Interleukin 7 IL-7 Adventitial cells of bone marrow Stimulates growth and differentiation of progenitor B and T cells Interleukin 8 IL-8 Macrophages, endothelial cells Acts as chemotactic factor on T lymphocytes and neutrophils Interleukin 9 IL-9 CD4T cells Facilitates growth of CD4T cell (but not CD8T cells) Stimulates growth of hematopoietic cells Activates mast cells Interleukin 10 IL-10 Macrophages, T cells Acts on T cells as cytokine synthesis inhibitory factor Inhibits macrophage functions Interleukin 11 IL-11 Macrophages Facilitates growth of hematopoietic cells, mainly megakaryocytes  FOLDER 14.3 Clinical Correlation: Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency