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15-3 Central deletion or inactivation of newly formed lymphocytes is the first checkpoint of self-tolerance.
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B. Type I diabetes mellitus ii. T‑cell‑mediated autoimmune attack against central nervous system myelin antigens, leading to demyelinating       disease with neurological phenotypes
C. Multiple sclerosis iii. Autoantibodies against IgG
D. Hashimoto’s thyroiditis iv. Autoantibodies against the GpIIb:IIIa fibrinogen  receptor on platelets
E. Autoimmune hemolytic v. Autoantibodies against anemia red blood cells
F. Autoimmune vi. TH1‑dependent thrombocytopenic autoimmune attack of purpura β cells in the pancreas
G. Goodpasture’s vii. Autoantibodies against syndrome the α3 chain of basement membrane collagen (type IV collagen)
H. Mixed essential viii. Cell‑ and autoantibody cryoglobulinemia mediated autoimmune  attack of the thyroid  leading to hypothyroidism
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15-4 Lymphocytes that bind self antigens with relatively low affinity usually ignore them but in some circumstances become activated.
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