Perelson, A.S., Essunger, P., Cao, Y.Z., Vesanen, M., Hurley, A., Saksela, K., Markowitz, M., and Ho, D.D.: Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997, 387:188–191.
Wei, X., Ghosh, S.K., Taylor, M.E., Johnson, V.A., Emini, E.A., Deutsch, P., Lifson, J.D., Bonhoeffer, S., Nowak, M.A., Hahn, B.H., et al.: Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995, 373:117–122.
13-36 In the course of infection HIV accumulates many mutations, which can result in the outgrowth of drug-resistant variants.
Condra, J.H., Schleif, W.A., Blahy, O.M., Gabryelski, L.J., Graham, D.J., Quintero, J.C., Rhodes, A., Robbins, H.L., Roth, E., Shivaprakash, M., et al.: In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 1995, 374:569–571.
Finzi, D., and Siliciano, R.F.: Viral dynamics in HIV-1 infection. Cell 1998, 93:665–671.
Katzenstein, D.: Combination therapies for HIV infection and genomic drug resistance. Lancet 1997, 350:970–971.
Moutouh, L., Corbeil, J., and Richman, D.D.: Recombination leads to the rapid emergence of HIV 1 dually resistant mutants under selective drug pressure. Proc. Natl Acad. Sci. USA 1996, 93:6106–6111.
13-37 Vaccination against HIV is an attractive solution but poses many difficulties.
Baba, T.W., Liska, V., Hofmann-Lehmann, R., Vlasak, J., Xu, W., Ayehunie, S., Cavacini, L.A., Posner, M.R., Katinger, H., Stiegler, G., et al.: Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian– human immunodeficiency virus infection. Nat. Med. 2000, 6:200–206.
Barouch, D.H.: The quest for an HIV-1 vaccine--moving forward. N. Engl. J. Med. 2013, 369:2073–2076.
Barouch, D.H., Kunstman, J., Kuroda, M.J., Schmitz, J.E., Santra, S., Peyerl, F.W., Krivulka, G.R., Beaudry, K., Lifton, M.A., Gorgone, D.A., et al.: Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature 2002, 415:335–339.
Isitman, G., Stratov, I., and Kent, S.J.: Antibody-dependent cellular cytotoxicity and Nk cell-driven immune escape in HIV Infection: Implications for HIV vaccine development. Adv. Virol. 2012, 212:637208.
Letvin, N.L.: Progress and obstacles in the development of an AIDS vaccine. Nat. Rev. Immunol. 2006, 6:930–939.