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7-8 Antigen recognition by the T-cell receptor and its co-receptors transduces a signal across the plasma membrane to initate signaling.
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7-9 Antigen recognition by the T-cell receptor and its co-receptors leads to phosphorylation of ITAMs by Src-family kinases, generating the first intracellular signal in a signaling cascade.
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7-10 Phosphorylated ITAMs recruit and activate the tyrosine kinase ZAP-70.
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7-11 ITAMs are also found in other receptors on leukocytes that signal for cell activation.
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7-12 Activated ZAP-70 phosphorylates scaffold proteins and promotes PI 3-kinase activation.