Cornall, R.J., Goodnow, C.C., and Cyster, J.G.: The regulation of self-reactive B cells. Curr. Opin. Immunol. 1995, 7:804–811.
Melamed, D., Benschop, R.J., Cambier, J.C., and Nemazee, D.: Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 1998, 92:173–182.
Nemazee, D.: Receptor editing in lymphocyte development and central tolerance. Nat. Rev. Immunol. 2006, 6:728–740.
Prak, E.L., and Weigert, M.: Light-chain replacement—a new model for antibody gene rearrangement. J. Exp. Med. 1995, 182:541–548.
8-7 Lymphocytes that encounter sufficient quantities of self antigens for the first time in the periphery are eliminated or inactivated.
Cyster, J.G., Hartley, S.B., and Goodnow, C.C.: Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 1994, 371:389–395.
Goodnow, C.C., Crosbie, J., Jorgensen, H., Brink, R.A., and Basten, A.: Induction of self-tolerance in mature peripheral B lymphocytes. Nature 1989, 342:385–391.
Lam, K.P., Kuhn, R., and Rajewsky, K.: In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997, 90:1073–1083.
Russell, D.M., Dembic, Z., Morahan, G., Miller, J.F.A.P., Burki, K., and Nemazee, D.: Peripheral deletion of self-reactive B cells. Nature 1991, 354:308–311.
Steinman, R.M., and Nussenzweig, M.C.: Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl Acad. Sci. USA 2002, 99:351–358.
8-8 Immature B cells arriving in the spleen turn over rapidly and require cytokines and positive signals through the B-cell receptor for maturation and survival.
Allman, D.M., Ferguson, S.E., Lentz, V.M., and Cancro, M.P.: Peripheral B cell maturation. II. Heat-stable antigenhi splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 1993, 151:4431–4444.
Harless, S.M., Lentz, V.M., Sah, A.P., Hsu, B.L., Clise-Dwyer, K., Hilbert, D.M., Hayes, C.E., and Cancro, M.P.: Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. Curr. Biol. 2001, 11:1986–1989.
Levine, M.H., Haberman, A.M., Sant’Angelo, D.B., Hannum, L.G., Cancro, M.P., Janeway, C.A., Jr., and Shlomchik, M.J.: A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proc. Natl Acad. Sci. USA 2000, 97:2743–2748.