13-30 A genetic deficiency of the co-receptor CCR5 confers resistance to HIV infection.
Gonzalez, E., Kulkarni, H., Bolivar, H., Mangano, A., Sanchez, R., Catano, G., Nibbs, R.J., Freedman, B.I., Quinones, M.P., Bamshad, M.J., et al.: The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science 2005, 307:1434–1440.
Liu, R., Paxton, W.A., Choe, S., Ceradini, D., Martin, S.R., Horuk, R., Macdonald, M.E., Stuhlmann, H., Koup, R.A., and Landau, N.R.: Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exposed individuals to HIV 1 infection. Cell 1996, 86:367–377.
Samson, M., Libert, F., Doranz, B.J., Rucker, J., Liesnard, C., Farber, C.M., Saragosti, S., Lapoumeroulie, C., Cognaux, J., Forceille, C., et al.: Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR 5 chemokine receptor gene. Nature 1996, 382:722–725.
13-31 An immune response controls but does not eliminate HIV.
Baltimore, D.: Lessons from people with nonprogressive HIV infection. N. Engl. J. Med. 1995, 332:259–260.
Barouch, D.H., and Letvin, N.L.: CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses. Curr. Opin. Immunol. 2001, 13:479–482.
Haase, A.T.: Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010, 464:217–223.
Ho, D.D., Neumann, A.U., Perelson, A.S., Chen, W., Leonard, J.M., and
Markowitz, M.: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123–126.
Liao, H.-X., Lynch, R., Zhou, T., Gao, F., Alam, S.M., Boyd, S.D., Fire, A.Z., Roskin, K.M., Schramm, C.A., Zhang, Z., et al.: Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 2013, 496:469–476.
Johnson, W.E., and Desrosiers, R.C.: Viral persistance: HIV’s strategies of immune system evasion. Annu. Rev. Med. 2002, 53:499–518.
McMichael, A.J., Borrow, P., Tomaras, G.D., Goonetilleke, N., and Haynes, B.F.: The immune response during acute HIV-1 infection: clues for vaccine development. Nat. Rev. Immunol. 2010, 10:11–23.
Price, D.A., Goulder, P.J., Klenerman, P., Sewell, A.K., Easterbrook, P.J., Troop, M., Bangham, C.R., and Phillips, R.E.: Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl Acad. Sci. USA 1997, 94:1890–1895.