Clifford DB: Neurological immune reconstitution inflammatory response: riding the tide of immune recovery, Curr Opin Neurol 28(3):295–301, 2015. [Discusses the clinical and pathological aspects of the inflammatory syndrome which can accompany initiation of HAART as a result of recovery of aspects of the immune system.]
Saylor D, Dickens AM, Sacktor N, et al: HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment, Nat Rev Neurol 12(4):234–248, 2016. [Summary of the underlying mechanisms for HIV-induced neurologic dysfunction and the impact of existing therapies on these complications of infection.]
Dendrou CA, Fugger L, Friese MA: Immunopathology of multiple sclerosis, Nat Rev Immunol 15(9):545–558, 2015. [While the immune basis of MS has been accepted for many years, it has become clear that there are increasing complexities of this injury to myelin, axons, and oligodendrocytes than previously assumed.]
Podestà MA, Faravelli I, Cucchiari D, et al: Neurological counterparts of hyponatremia: pathological mechanisms and clinical manifestations, Curr Neurol Neurosci Rep 15(4):18, 2015. [The mechanistic relationship between alterations in serum osmolality and acute injury to myelin remains complex but is partially addressed in this discussion.]
Yang X, Ransom BR, Ma JF: The role of AQP4 in neuromyelitis optica: More answers, more questions, J Neuroimmunol 298:63–70, 2016. [While the presence of antibodies to aquaporin-4 helped clarify the syndrome of neuromyelitis optica, it remains a more complex disease than a simple autoimmune disorder.]
Barker RA, Williams-Gray CH: Review: the spectrum of clinical features seen with alpha synuclein pathology, Neuropathol Appl Neurobiol 42(1):6–19, 2016. [Aggregation of α-synuclein marks several neurodegenerative diseases, and this review considers shared and distinct aspects of the pathologic findings.]
Colonna M, Wang Y: TREM2 variants: new keys to decipher Alzheimer disease pathogenesis, Nat Rev Neurosci 17(4):201–207, 2016. [One of the strongest links between Alzheimer disease and microglia is the risk associated with variants of TREM2 on the surfaces of microglia.]
Ling SC, Polymenidou M, Cleveland DW: Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis, Neuron 79(3):416–438, 2013. [A clear summary of mechanisms associated with neurodegeneration that can be linked to the consequences of altered RNA dynamics within cells and the consequence of this for proteins.] http://ebooksmedicine.net
Mackenzie IR, Neumann M: Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies, J Neurochem 138(Suppl 1):54–70, 2016. [A consideration of the complex family of disorders that give rise to frontotemporal lobe degenerations, with different clinical pictures as well as different histologic findings and associated mechanisms.]
Selkoe DJ, Hardy J: The amyloid hypothesis of Alzheimer’s disease at 25 years, EMBO Mol Med 8(6):595–608, 2016. [A current summary of the relationship of Aβ to the pathogenesis of Alzheimer disease.]