O’Shea JJ, Paul WE: Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells, Science 327:1098, 2010. [An excellent review of the development and functions of helper T cell subsets, and the uncertainties in the field.]
Ohkura N, Kitagawa Y, Sakaguchi S: Development and maintenance of regulatory T cells, Immunity 38:414–423, 2013. [An excellent review of the molecular mechanisms underlying the generation, maintenance, and stability of regulatory T cells.]
Pattanaik D, Brown M, Postlethwaite BC, et al: Pathogenesis of systemic sclerosis, Front Immunol 6:272, 2015. [A discussion of current concepts of the pathogenesis of systemic sclerosis.]
Parvaneh N, Casanova JL, Notarangelo LD, et al: Primary immunodeficiencies: a rapidly evolving story, J Allergy Clin Immunol 131:314–323, 2013. [An excellent review of newly described primary immunodeficiency syndromes.]
Schwartz RH: Historical overview of immunological tolerance, Cold Spring Harb Perspect Biol 4:a006908, 2012. [A thoughtful summary of the mechanisms of tolerance, the experimental studies behind the elucidation of these mechanisms, and how they may be disrupted to give rise to autoimmunity.]
Tsokos GC: Systemic lupus erythematosus, N Engl J Med 365:2110, 2011. [An excellent review of the clinical features and pathogenesis of lupus.]
Westermark GT, Fandrich M, Westermark P: AA amyloidosis: pathogenesis and targeted therapies, Annu Rev Pathol 10:321, 2015. [An excellent review of the pathogenesis and clinical features of a major form of amyloidosis.]
Victora GD, Nussenzweig MC: Germinal centers, Annu Rev Immunol 30:429–457, 2012. [An excellent review of the properties and formation of germinal centers and their roles in antibody responses and autoimmune diseases.]
Voight BF, Cotsapas C: Human genetics offers an emerging picture of common pathways and mechanisms in autoimmunity, Curr Opin Immunol 24:552–557, 2012. [A discussion of the genetic associations with autoimmune diseases and the implications for understanding pathways of autoimmunity.]
Weaver CT, Elson CO, Fouser LA, et al: The TH17 pathway and inflammatory diseases of the intestines, lungs, and skin, Annu Rev Pathol 8:477, 2013. [An excellent review of the development and lineage relationships of TH17 cells and their roles in autoimmune and other inflammatory diseases.]
Zenewicz L, Abraham C, Flavell RA, et al: Unraveling the genetics of autoimmunity, Cell 140:791, 2010. [An update on susceptibility genes for autoimmune diseases, how these are identified, and their significance.] http://ebooksmedicine.net studentconsult.com
Carcinogenesis:AMultistepProcess
Insensitivity to Growth Inhibitory Signals:Tumor
Evasion of Cell Death
Evasion of Immune Surveillance
Tumor-Promoting Inflammation as an Enabler of Malignancy
EtiologyofCancer:CarcinogenicAgents
Effects of Tumor on Host
Grading and Staging of Cancer
Laboratory Diagnosis of Cancer