Padovan, E., Casorati, G., Dellabona, P., Meyer, S., Brockhaus, M., and Lanzavecchia, A.: Expression of two T-cell receptor α chains: dual receptor T cells. Science 1993, 262:422–424.
Petrie, H.T., Livak, F., Schatz, D.G., Strasser, A., Crispe, I.N., and Shortman, K.: Multiple rearrangements in T-cell receptor α-chain genes maximize the production of useful thymocytes. J. Exp. Med. 1993, 178:615–622.
8-19 Only thymocytes whose receptors interact with self peptide:self MHC complexes can survive and mature.
Hogquist, K.A., Tomlinson, A.J., Kieper, W.C., McGargill, M.A., Hart, M.C., Naylor, S., and Jameson, S.C.: Identification of a naturally occurring ligand for thymic positive selection. Immunity 1997, 6:389–399.
Kisielow, P., Teh, H.S., Blüthmann, H., and von Boehmer, H.: Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 1988, 335:730–733.
8-20 Positive selection acts on a repertoire of T-cell receptors with inherent specificity for MHC molecules.
Marrack, P., Scott-Browne, J.P., Dai, S., Gapin, L., and Kappler, J.W.: Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu. Rev. Immunol. 2008, 26:171–203.
Merkenschlager, M., Graf, D., Lovatt, M., Bommhardt, U., Zamoyska, R., and Fisher, A.G.: How many thymocytes audition for selection? J. Exp. Med. 1997, 186:1149–1158.
Scott-Browne, J.P., White, J., Kappler, J.W., Gapin, L., and Marrack, P.: Germlineencoded amino acids in the αβ T-cell receptor control thymic selection. Nature 2009, 458:1043–1046.
Zerrahn, J., Held, W., and Raulet, D.H.: The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 1997, 88:627–636.
8-21 Positive selection coordinates the expression of CD4 or CD8 with the specificity of the T-cell receptor and the potential effector functions of the T cell.
Egawa, T., and Littman, D.R.: ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat. Immunol. 2008, 9:1131–1139.
He, X., Xi, H., Dave, V.P., Zhang, Y., Hua, X., Nicolas, E., Xu, W., Roe, B.A., and Kappes, D.J.: The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 2005, 433:826–833.
Singer, A., Adoro, S., and Park, J.H.: Lineage fate and intense debate: myths, models and mechanisms of CD4versus CD8-lineage choice. Nat. Rev. Immunol. 2008, 8:788–801.