Geddes, K., Rubino, S.J., Magalhaes, J.G., Streutker, C., Le Bourhis, L., Cho, J.H., Robertson, S.J., Kim, C.J., Kaul, R., Philpott, D.J., et al: Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat. Med. 2011, 17:837–844.
Lassen, K.G., Kuballa, P., Conway, K.L., Patel, K.K., Becker, C.E., Peloquin, J.M., Villablanca, E.J., Norman, J.M., Liu, T.C., Heath, R.J., et al.: Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc. Natl Acad. Sci. USA 2014, 111:7741–7746.
Prescott, D., Lee, J., and Philpott, D.J.: An epithelial armamentarium to sense the microbiota. Semin. Immunol. 2013, 25:323–333.
Song-Zhao, G.X., Srinivasan, N., Pott, J., Baban, D., Frankel, G., and Maloy, K.J.: Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen. Mucosal Immunol. 2014, 7:763–774.
12-16 Pathogens induce adaptive immune responses when innate defenses have been breached.
Bain, C.C., and Mowat, A.M.: Macrophages in intestinal homeostasis and inflammation. Immunol. Rev. 2014: 260:102–117.
Farache, J., Koren, I., Milo, I., Gurevich, I., Kim, K.W., Zigmond, E., Furtado, G.C., Lira, S.A., and Shakhar, G.: Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation. Immunity 2013, 38:581–595.
Persson, E.K., Scott, C.L., Mowat, A.M., and Agace, W.W.: Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function. Eu. J. Immunol. 2013, 43:3098–3107.
Salazar-Gonzalez, R.M., Niess, J.H., Zammit, D.J., Ravindran, R., Srinivasan, A., Maxwell, J.R., Stoklasek, T., Yadav, R., Williams, I.R., Gu, X., et al.: CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer’s patches. Immunity 2006, 24:623–632.
Uematsu, S., Jang, M.H., Chevrier, N., Guo, Z., Kumagai, Y., Yamamoto, M., Kato, H., Sougawa, N., Matsui, H., Kuwata, H., et al.: Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat. Immunol. 2006, 7:868–874.
12-17 Effector T-cell responses in the intestine protect the function of the epithelium.