Wang, S., Zhu, G., Chapoval, A.I., Dong, H., Tamada, K., Ni, J., and Chen, L.: Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000, 96:2808–2813.
9-16 CD28-dependent co-stimulation of activated T cells induces expression of interleukin-2 and the high-affinity IL-2 receptor.
Acuto, O., and Michel, F.: CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat. Rev. Immunol. 2003, 3:939–951.
Gaffen, S.L.: Signaling domains of the interleukin 2 receptor. Cytokine 2001, 14:63–77.
Seko, Y., Cole, S., Kasprzak, W., Shapiro, B.A., and Ragheb, J.A.: The role of cytokine mRNA stability in the pathogenesis of autoimmune disease. Autoimmun. Rev. 2006, 5:299–305.
Zhou, X.Y., Yashiro-Ohtani, Y., Nakahira, M., Park, W.R., Abe, R., Hamaoka, T., Naramura, M., Gu, H., and Fujiwara, H.: Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation. J. Immunol. 2002, 168:3847–3854.
9-17 Additional co-stimulatory pathways involved in T-cell activation.
Croft, M.: The role of TNF superfamily members in T-cell function and diseases. Nat. Rev. Immunol. 2009, 9:271–285.
Greenwald, R.J., Freeman, G.J., and Sharpe, A.H.: The B7 family revisited. Annu. Rev. Immunol. 2005, 23:515–548.
Watts, T.H.: TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 2005, 23:23–68.
9-18 Proliferating T cells differentiate into effector T cells that do not require co-stimulation to act.
Gudmundsdottir, H., Wells, A.D., and Turka, L.A.: Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 1999, 162:5212–5223.
London, C.A., Lodge, M.P., and Abbas, A.K.: Functional responses and costimulator dependence of memory CD4+ T cells. J. Immunol. 2000, 164:265–272.
Schweitzer, A.N., and Sharpe, A.H.: Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production. J. Immunol. 1998, 161:2762–2771.
9-19 CD8 T cells can be activated in different ways to become cytotoxic effector cells.
Andreasen, S.O., Christensen, J.E., Marker, O., and Thomsen, A.R.: Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J. Immunol. 2000, 164:3689–3697.