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11-3 Effector T cells are guided to specific tissues and sites of infection by changes in their expression of adhesion molecules and chemokine receptors.
Griffith, J.W., Sokol, C.L., and Luster, A.D.: Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu. Rev. Immunol. 2014, 32:659–702.
Hidalgo, A., Peired, A.J., Wild, M.K., Vestweber, D., and Frenette, P.S.: Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44. Immunity 2007, 26:477–489.
MacKay, C.R., Marston, W., and Dudler, L.: Altered patterns of T-cell migration through lymph nodes and skin following antigen challenge. Eur. J. Immunol. 1992, 22:2205–2210.
Mantovani, A., Bonecchi, R., and Locati, M.: Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat. Rev. Immunol. 2006, 6:907–918.
Mueller, S.N., Gebhardt, T., Carbone, F.R., and Heath, W.R.: Memory T cell subsets, migration patterns, and tissue residence. Annu. Rev. Immunol. 2013, 31:137–161.
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11-4 Pathogen-specific effector T cells are enriched at sites of infection as adaptive immunity progresses.
Jenkins, M.K., Khoruts, A., Ingulli, E., Mueller, D.L., McSorley, S.J., Reinhardt, R.L., Itano, A., and Pape, K.A.: In vivo activation of antigen-specific CD4 T cells. Annu. Rev. Immunol. 2001, 19:23–45.
11-5 TH1 cells coordinate and amplify the host response to intracellular pathogens through classical activation of macrophages.
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Ehlers, S., Kutsch, S., Ehlers, E.M., Benini, J., and Pfeffer, K.: Lethal granuloma disintegration in mycobacteria-infected TNFRp55–/– mice is dependent on T cells and IL-12. J. Immunol. 2000, 165:483–492.