Human transferrin is encoded by the TF gene. Transferrin glycoproteins bind iron tightly, but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of total body iron, it forms the most vital iron pool with the highest rate of turnover (25 mg/24 h).Transferrin has a molecular weight of around 80 KDa and contains two specific high-affinity Fe(III) binding sites.ach transferrin molecule has the ability to carry two iron ions in the ferric form (Fe3+). The gene coding for transferrin in humans is located in chromosome band 3q21. Medical professionals may check serum transferrin level in iron deficiency and in iron overload disorders such as hemochromatosis.
https://en.wikipedia.org/wiki/Transferrin
Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration.It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis.fR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and is unaffected by intracellular iron concentrations. TfR2 binds to transferrin with a 25-30 fold lower affinity than TfR1.
https://en.wikipedia.org/wiki/Transferrin_receptor
The transferrin is abnormally high in iron deficiency anemia. The gene for transferrin is in chromosome band 3q21. Hereditary absence of transferrin is called atransferrinemia. It is characterized by anemia and hemosiderosis (iron deposition) in the heart and liver.The iron damage to the heart can lead to heart failure.The anemia is typically microcytic and hypochromic (the red blood cells are abnormally small and pale).he blood transferrin level is tested for diverse reasons: to determine the cause of anemia, to examine iron metabolism (for example, in iron deficiency anemia) and to determine the iron-carrying capacity of the blood.
http://www.medicinenet.com/script/main/art.asp?articlekey=15591
Human holo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Human holo-transferrin is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media.ransferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface.
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Transferrin is the iron-transport protein of vertebrate serum and donates iron to cells through interaction with a specific membrane receptor, CD71. Transferrin appears to be indispensable for most cells growing in tissue culture.uman Holo Transferrin is a glycoprotein of approximately 77 kDa containing 679 amino acids. Physical Appearance.
http://www.prospecbio.com/Holo_Transferrin_Human_11_121
Definition: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation.efinition: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation.
http://www.reference.md/files/C110/mC110714.html
Transferrin also has a transferrin iron-bound receptor; it is a disulfide-linked homodimer. In humans, each monomer consists of 760 amino acids. It enables ligand bonding to the transferrin, as each monomer can bind to one or two molecules of iron.ach transferrin molecule has the ability to carry two iron ions in the ferric form (Fe3+). The gene coding for transferrin in humans is located in chromosome band 3q21. Medical professionals may check serum transferrin level in iron deficiency and in iron overload disorders such as hemochromatosis.
https://en.wikipedia.org/wiki/Transferrin
The ferric iron then binds to. (the iron-free form of transferrin) in the plasma to form Fe(III)-transferrin (TF) complex, which is the major type of iron present in blood.Iron transport & homeostasis mechanisms: their role in health & ...by Nadadur, S.S.; Srirama, K.; Mudipalli, Anuradha / Indian Journal of Medical Research.he ferric iron then binds to. (the iron-free form of transferrin) in the plasma to form Fe(III)-transferrin (TF) complex, which is the major type of iron present in blood. Iron transport & homeostasis mechanisms: their role in health & ...
http://medical-dictionary.thefreedictionary.com/Apotransferrin
Apart from its role as an iron transport protein transferrin acts as a cytokine and has functions that may not be related to its iron-carrying capacity.Human Transferrin is a crucial component for the cultivation of mammalian cells in-vitro. Human Transferrin is Critical for long-term cells growth in-vitro.uman Holo Transferrin is a glycoprotein of approximately 77 kDa containing 679 amino acids. Physical Appearance.
http://www.prospecbio.com/Holo_Transferrin_Human_11_121
Description. Human Holo Transferrin is a glycoprotein of approximately 77 kDa containing 679 amino acids.Physical Appearance.uman Holo Transferrin is a glycoprotein of approximately 77 kDa containing 679 amino acids. Physical Appearance.
http://www.prospecbio.com/Holo_Transferrin_Human_11_121
holotransferrin definition
Human holo-transferrin is a high affinity transferrin that can be used with a wide range of cells types.