Brand Name: Zaroxolyn. Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Metolazone is used to treat fluid retention (edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome. Metolazone is also used to treat high blood pressure (hypertension).
https://www.drugs.com/mtm/zaroxolyn.html
What is Zaroxolyn (metolazone)? Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Metolazone is used to treat fluid retention (edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome. Metolazone is also used to treat high blood pressure (hypertension). Metolazone may also be used for purposes not listed in this medication guide.
https://www.drugs.com/mtm/zaroxolyn.html
Other products introduced at the end of or subsequent to the third quarter ended September 30, 2003 that also contributed to the increase in net sales included Midodrine HCl, Metolazone USP, Benazepril HCl and Benazepril HCl/HCTZ and Fosinopril.
http://medical-dictionary.thefreedictionary.com/metolazone
Other products introduced at the end of or subsequent to the fourth quarter ended December 31, 2003 that also contributed to the increase in net sales included Metolazone, Citalopram, Fosinopril and Cilostazol.
http://medical-dictionary.thefreedictionary.com/metolazone
The primary target of all thiazide diuretics, including metolazone, is the distal convoluted tubule, part of the nephron in the kidney, where they inhibit the sodium-chloride symporter. In the kidney, blood is filtered into the lumen, or open space, of the nephron tubule.
https://en.wikipedia.org/wiki/Metolazone
Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, blood dyscrasias, chest or joint pain, cutaneous vasculitis.
http://www.empr.com/zaroxolyn/drug/210/
In mild heart failure, metolazone or another diuretic may be used alone, or combined with other diuretics for moderate or severe heart failure. In addition to preventing fluid buildup, the use of metolazone may allow the patient to relax the amount of sodium restriction that is required.
https://en.wikipedia.org/wiki/Metolazone
Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream.
https://en.wikipedia.org/wiki/Metolazone
It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases.
https://en.wikipedia.org/wiki/Metolazone
Metolazone is a quinazoline, a derivative of the similar diuretic quinethazone, as well as a sulfonamide. It is related to analogs of 1,2,4-benzothiadizine-1,1-dioxide (benzothiadiazine). These drugs are called benzothiadiazides, or thiazides for short.
https://en.wikipedia.org/wiki/Metolazone
what is zaroxolyn
Zaroxolyn is a thiazide diuretic or water pill that helps prevent your body from absorbing too much salt, which can cause fluid retention.