Mechanism of action. The binding site for clindamycin is on the 50S subunit of the bacterial ribosome which is identical with that for erythromycin. Clindamycin, like erythromycin, suppresses protein synthesis by interfering with the development of initiation complexes and with aminoacyl translocation reactions.
http://www.antibiotics-info.org/clindamycin.html
Resistance to clindamycin, which usually confers cross-resistance to macrolides, is due to (1) mutation of the ribosomal receptor site; (2) modification of the receptor by a constitutively expressed adenine methylase ; and (3) enzymatic inactivation (plasmid mediated adenyl transferase) of clindamycin.
http://www.antibiotics-info.org/clindamycin.html
Take clindamycin for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Clindamycin will not treat a viral infection such as the common cold or flu.
https://www.drugs.com/clindamycin.html
You should not use this medicine if you are allergic to clindamycin or lincomycin. To make sure clindamycin is safe for you, tell your doctor if you have: a history of colitis, Crohn's disease, or other intestinal disorder; a history of eczema, or allergic skin reaction;
https://www.drugs.com/clindamycin.html
Clindamycin is an antibiotic that fights bacteria in the body. Clindamycin is used to treat serious infections caused by bacteria. Clindamycin may also be used for purposes not listed in this medication guide.
https://www.drugs.com/clindamycin.html
Clindamycin (600 mg IV 8 hourly, or 300-450 mg orally 6 hourly for less severe disease) in combination with primaquine (15 mg of base once daily) is beneficial for the treatment of mild to moderate cases of P. jiroveci pneumonia in AIDS patients.
http://www.antibiotics-info.org/clindamycin.html
Clindamycin is inactivated by metabolism to N-demethylclindamycin and clindamycin sulfoxide, which are excreted in the urine and bile. Build-up of clindamycin can occur in severe hepatic failure, and dosage adjustments may be essential.
http://www.antibiotics-info.org/clindamycin.html
Clindamycin is a chlorine-substituted derivative of lincomycin, an antibiotic that is elaborated by Streptomyces lincolnensis. It issemi-synthetic and belongs to lincosamide class. It isa derivative of the amino acid trans-L-4-n-propylhygrinic acid, attached to a sulfur-containing derivative of an octose.
http://www.antibiotics-info.org/clindamycin.html
Lincosamides are a class of antibiotics which include lincomycin, clindamycin, and pirlimycin.
https://en.wikipedia.org/wiki/Lincosamides
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Clindamycin will not treat a viral infection such as the flu or a common cold.
https://www.drugs.com/clindamycin.html
is clindamycin a derivative of penicillin
No, Clindamycin is not a derivative of penicillin.