Cefotaxime is contraindicated in patients with a known hypersensitivity to cefotaxime or other cephalosporins. Caution should be used and risks weighed against potential benefits in patients with an allergy to penicillin, due to cross-reactivity between the classes.
https://en.wikipedia.org/wiki/Cefotaxime
Cefotaxime is the only cephalosporin which has very low toxicity in plants, even at higher concentration (up to 500 mg/l). It is widely used to treat plant tissue infections with Gram-negative bacteria, while vancomycin is used to treat the plant tissue infections with Gram-positive bacteria.
https://en.wikipedia.org/wiki/Cefotaxime
Cephalosporins are b-lactam antibiotics that differ from the penicillins in that the B ring is a 6-. membered dihydrothiazine ring. Variations among the cephalosporins are made on either the acyl side. chain at the 7-position to change antibacterial activity or at the 3-position to alter the pharmacokinetic. profile.
http://courses.ahc.umn.edu/pharmacy/6124/remmel_notes/cephalosporins.pdf
Cefotaxime is a β-lactam antibiotic (which refers to the structural components of the drug molecule itself). As a class, β-lactams inhibit bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
https://en.wikipedia.org/wiki/Cefotaxime
Cefotaxime was discovered in 1976. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
https://en.wikipedia.org/wiki/Cefotaxime
Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls.
http://www.fpnotebook.com/ID/Pharm/ThrdGnrtnBrdSpctrmCphlsprns.htm
• However, degree and extent of binding to different PBPs may be different for the cephalosporins. than for penicillins. For example, cephalothin causes lysis of Staph. aureus, whereas cephalexin. produces long filamentous forms in E. coli. • In general, cephalosporins are less susceptible to b-lactamases compared to penicillins. 47. Cephalosporin!!!!!!!!!!!!!R1!!!!!!!!!!!!!!!!!!!!!!!!!R2!!!!!!!!!!!!!!!!!!!!!!!!R3. Table 18.
http://courses.ahc.umn.edu/pharmacy/6124/remmel_notes/cephalosporins.pdf
As a β-lactam antibiotic in the third-generation class of cephalosporins, cefotaxime is active against numerous Gram-positive and Gram-negative bacteria, including several with resistance to classic β-lactams such as penicillin.
https://en.wikipedia.org/wiki/Cefotaxime
These images are a random sampling from a Bing search on the term Third Generation Broad-Spectrum Cephalosporins.. Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images.
http://www.fpnotebook.com/ID/Pharm/ThrdGnrtnBrdSpctrmCphlsprns.htm
Third Generation Broad-Spectrum Cephalosporins. Aka: Third Generation Broad-Spectrum Cephalosporins, Third Generation Cephalosporins, Ceftriaxone, Ceftizoxime, Cefotaxime, Cefpodoxime, Cefixime, Claforan, Rocephin, Vantin.
http://www.fpnotebook.com/ID/Pharm/ThrdGnrtnBrdSpctrmCphlsprns.htm
what generation is cefotaxime
Cefotaxime is athird generation. Cefotaxime is third generation.