The best initial antibiotic choice is thought to be a macrolide. Macrolides provide the best coverage for the most likely organisms in community-acquired bacterial pneumonia (CAP). Macrolides have effective coverage for gram-positive, Legionella, and Mycoplasma organisms.
http://emedicine.medscape.com/article/300157-medication
Ceftriaxone (Rocephin). Ceftriaxone is a third-generation cephalosporin with broad-spectrum gram-negative activity; low efficacy against gram-positive organisms; and high efficacy against resistant organisms. It is considered the drug of choice for parenteral agents in community-acquired pneumonia.
http://emedicine.medscape.com/article/300157-medication
Other important factors that have yet to be determined include determining the superiority of site-specific versus organism-specific rotation strategies, optimal duration of rotation periods, optimal number of antibiotics utilized in a rotation protocol, types of antibiotics utilized, and in what order.
http://www.medscape.com/viewarticle/445667_4
The effect of a rotation protocol should be cumulative thus making analysis of the effect of specific time periods and specific antibiotics less meaningful. To date only a handful of prospective antibiotic rotation studies have been performed, but all have shown uniformly encouraging results. Kollef et al. Further investigation by Gruson and colleagues Staphylococcus aureus pneumonia (60% vs 37%; p = 0.013). There was no difference in associated mortality (40.6% vs 37.2%; p = NS), however mortality was not a primary end point of the study.
http://www.medscape.com/viewarticle/445667_4
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1 Antibiotics. 2  Bacteria and Antibiotics. 3  Antibiotics--the Basics. 4  Drugs-Antibiotics. 5  MIP: Antibiotics. 6  antibiotic questions. 7  Introduction to Antibiotics. 8  Antibiotics use. 9  Bacterial Antibiotic Therapy. 10  Infections Bacterial Pathogens and An...
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TMP/SMX or FQ. Yersinia pestis. Streptomycin, gentamicin. {cdnAssetsUrl:\/\/fce-study.netdna-ssl.com\/44a60677764b,site_dot_caption:Cram.com,premium_user:false,premium_set:false,payreferer:clone_set,payreferer_set_title:Antibiotics for specific organisms,payreferer_url ....
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Medication Summary. The mainstay of drug therapy for bacterial pneumonia is antibiotic treatment. The choice of agent is based on the severity of the patient's illness, host factors (eg, comorbidity, age), and the presumed causative agent.
http://emedicine.medscape.com/article/300157-medication
Imipenem and cilastatin is a carbapenem antibiotic used for treatment of multiple organism infections in which other agents do not have wide spectrum coverage or are contraindicated due to the potential for toxicity.
http://emedicine.medscape.com/article/300157-medication
Finally, we have recently published our experience at the University of Virginia. Although the data certainly support the use of antibiotic rotation or cycling as an effective means to limit antibiotic resistance, many questions remain.
http://www.medscape.com/viewarticle/445667_4
organism-specific antibiotics are used to treat:
Organism-specific antibiotics are used to treat organism infections.