Amyloidosis. Amyloidosis is a clinical disorder caused by extracellular and/or intracellular deposition of insoluble abnormal amyloid fibrils that alter the normal function of tissues.
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Systemic amyloidosis Internal medicine A group of diseases in which amyloid protein is deposited in specific organs–localized amyloidosis or throughout the body–systemic amyloidosis deposition of amyloid, which can be 1º, which usually affects nerves, skin, tongue, joints, heart, or liver, or 2º to other conditions–eg, TB, CA, leprosy, and accompanied by immune system changes, which affect the spleen, kidneys, liver, and adrenal glands.
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Both types of amyloidosis contain amyloid P component, a non-fibrillary glycoprotein found in the circulation; scintigraphy after injection of 123I-labelled serum amyloid P component can locate tissue deposition of amyloidosis and, if the deposition is active, cytotoxic therapy may be instituted; focal amyloidosis commonly occurs in those organs most susceptible to ageing (e.g., the heart and brain), and is only symptomatic if the amyloid deposition is significant.
https://medical-dictionary.thefreedictionary.com/amyloidosis
familial amyloidosis any inherited form of amyloidosis; usually used to denote any of various systemic autosomal dominant disorders of amyloid deposition that involve the nervous system. The most common form, ATTR amyloidosis, is associated with mutations of the transthyretin protein, but rare mutations of other proteins can also be a cause.
https://medical-dictionary.thefreedictionary.com/amyloidosis
Amyloidosis - Treatment of Amyloidosis. 1  A pilot study demonstrated reduction in arthralgia and increased range of motion with doxycycline treatment. 2  β2-m–adsorbing columns have demonstrated some benefit in dialysis-related amyloidosis. 3  Aβ immunotherapies have shown some promise in the treatment of Alzheimer disease.
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For example, in most cases formerly called primary amyloidosis and in myeloma-associated amyloidosis, the fibril protein is an immunoglobulin light chain or light chain fragment (abbreviated L); thus, patients with these amyloidoses are now said to have light chain amyloidosis (AL).
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Amyloidosis occurs in conditions of chronic inflammation, such as TUBERCULOSIS, leprosy (HANSEN'S DISEASE) and RHEUMATOID ARTHRITIS and in B lymphocyte disorders, such as MYELOMATOSIS. Local amyloidosis of the islets of Langerhans in the pancreas is a feature of maturity onset (Type II) DIABETES. Rarely, no predisposing cause can be identified.
https://medical-dictionary.thefreedictionary.com/amyloidosis
Amyloid is defined as in vivo deposited material distinguished by the following: 1  Fibrillar appearance on electron micrography. 2  Amorphous eosinophilic appearance on hematoxylin and eosin staining (see first image below) 3  Beta-pleated sheet structure as observed by x-ray diffraction pattern.
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Amyloid proteins are manufactured by malfunctioning bone marrow. Amyloidosis, which occurs when accumulated amyloid deposits impair normal body function, can cause organ failure or death. It is a rare disease, occurring in about eight of every 1,000,000 people. It affects males and females equally and usually develops after the age of 40.
https://medical-dictionary.thefreedictionary.com/amyloidosis
Amyloidosis - Definition of Amyloid and Amyloidosis. 1  Amyloid is defined as in vivo deposited material distinguished by the following... 2  All types of amyloid consist of one major fibrillar protein that defines the type of amyloid.
http://emedicine.medscape.com/article/335414-overview
define amyloidosis
Amyloidosis is a clinical disorder caused by extracellular and or intracellular deposition of insoluble abnormal amyloid fibrils that alter the normal function of tissues.   Amyloidosis is a clinical disorder caused by extracellular and/or intracellular deposition of insoluble abnormal amyloid fibrils that alter the normal function of tissues.