People with acute promyelocytic leukemia are especially susceptible to developing bruises, small red dots under the skin (petechiae), nosebleeds, bleeding from the gums, blood in the urine (hematuria), or excessive menstrual bleeding.
https://ghr.nlm.nih.gov/condition/acute-promyelocytic-leukemia
Acute promyelocytic leukemia (APL) accounts for 5-15% of all adult leukemias.There are approximately 30,800 cases of acute leukemia diagnosed yearly; about 1000 of these are acute promyelocytic leukemia (APL). The annual incidence of acute promyelocytic leukemia (APL) in Italy is approximately 0.6 per 1 million people.
http://emedicine.medscape.com/article/1495306-overview
Acute promyelocytic leukemia (APL) is a unique subtype of the acute leukemias. It has distinct cytogenetics, clinical features, and biologic characteristics. APL is caused by an arrest of leukocyte differentiation at the promyelocyte stage.
http://emedicine.medscape.com/article/1495306-overview
The low number of red blood cells (anemia) can cause people with acute promyelocytic leukemia to have pale skin (pallor) or excessive tiredness (fatigue). In addition, affected individuals may heal slowly from injuries or have frequent infections due to the loss of normal white blood cells that fight infection.
https://ghr.nlm.nih.gov/condition/acute-promyelocytic-leukemia
Up to 70% of leukemia cases are over the age of 50, which is enough to officially classify age as the biggest risk factor for developing leukemia. The reasons for this is that in older people, the chromosomes of white blood cells are more fragile than in younger people and thus are more susceptible to DNA damage.
https://www.quora.com/How-does-leukemia-develop
Great question. Leukemia develops when DNA damage occurs in white blood cells, the cells that fight pathogens and protect the body from infection. Leukemia is associated with several genetic abnormalities, including chromosome translocations ( shifting, rearranging of chromosomes ) and mutations.
https://www.quora.com/How-does-leukemia-develop
Acute promyelocytic leukemia (APL) is defined by its cytogenetic properties. Over 95% of cases are characterized by a balanced translocation between chromosome 17q21 and chromosome 15q22. This leads to an abnormal fusion protein called PML-RARA.
http://emedicine.medscape.com/article/1495306-overview
In fact, this treatment is recognized as a major cause of AML ( a type of leukemia ) in children. AML can also stem from treatment for breast cancer, ovarian cancer, Hodgkin's Disease, and non-Hodgkin's lymphoma, accounting for 20% of AML cases. Radiation.
https://www.quora.com/How-does-leukemia-develop
Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow).
https://ghr.nlm.nih.gov/condition/acute-promyelocytic-leukemia
In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.
https://ghr.nlm.nih.gov/condition/acute-promyelocytic-leukemia
how does acute promyelocytic leukemia develop
The low number of red blood cells can cause people with acute promyelocytic leukemia to have pale skin or excessive tiredness. The low number of red blood cells can cause people with acute Promyelocytic Leukemia to have pale skin and excessive tiredness.