The CSF is formed by the choroid plexus (50%) and directly from the walls of the ventricules (50%). CSF flows through the foramens of Magendie & Luschka into the subarachnoid space of the brain and spinal cord. It is absorbed by the arachnoid villi (90%) and directly into cerebral venules (10%).
http://www.anaesthesiamcq.com/FluidBook/fl3_6.php
The concurrent values in the cerebrospinal fluid were pH of 7.365, PCO2 of 15.5 mm. of mercury and bicarbonate of 8.5 mEq. per liter. Fluids containing 100 to 150 mEq. of sodium bicarbonate per liter were infused intravenously at a rate of 3 liters per day, and the serum pH returned to normal during the next 2 days.
http://www.nejm.org/doi/full/10.1056/NEJM196709212771201
3.6 Cerebrospinal Fluid. Cerebrospinal fluid (CSF) is considered a part of the transcellular fluids. It is contained in the ventricles and the subarachnoid space and bathes the brain and spinal cord. The CSF is contained within the meninges and acts as a cushion to protect the brain from injury with position or movement.
http://www.anaesthesiamcq.com/FluidBook/fl3_6.php
In 5 patients severe metabolic acidosis (serum pH less than 7.0 in 3) was associated with a near normal pH in the cerebrospinal fluid and with normal mental function. Two of the 5 patients, when treated rapidly with sodium bicarbonate infusions, had an acid pH in the cerebrospinal fluid as the serum pH was corrected.
http://www.nejm.org/doi/full/10.1056/NEJM196709212771201
RECENTLY, we have encountered a series of patients with severe metabolic acidosis and serum pH values less than 7.0. Although such severe acidosis is widely regarded as leading rapidly to delirium and unconsciousness, only some of these patients were in coma; the others were awake and alert.
http://www.nejm.org/doi/full/10.1056/NEJM196709212771201
The cerebrospinal fluid (CSF) is produced from arterial blood by the choroid plexuses of the lateral and fourth ventricles by a combined process of diffusion, pinocytosis and active transfer. A small amount is also produced by ependymal cells.
http://neuropathology-web.org/chapter14/chapter14CSF.html
The initial serum and cerebrospinal-fluid acid–base values (Table 1) revealed a severe serum acidosis (pH 6.988) partially compensated by hyperventilation (PaCO2 of 11 mm. of mercury); the pH of the cerebrospinal fluid was minimally acidotic (7.255).
http://www.nejm.org/doi/full/10.1056/NEJM196709212771201
At a pressure of about 11cmsH2O, the rate of secretion & absorption are equal. The CSF has a composition identical to that of the brain ECF but this is different from plasma. The major differences from plasma are: The pCO2 is higher (50 mmHg) resulting in a lower CSF pH (7.33)
http://www.anaesthesiamcq.com/FluidBook/fl3_6.php
These are covered by modified ependymal cells with bulbous microvilli. The total volume of CSF in the adult ranges from140 to 270 ml. The volume of the ventricles is about 25 ml. CSF is produced at a rate of 0.2 - 0.7 ml per minute or 600-700 ml per day. The circulation of CSF is aided by the pulsations of the choroid plexus and by the motion of the cilia of ependymal cells.
http://neuropathology-web.org/chapter14/chapter14CSF.html
How long the first 3 patients had serum pH levels of 6.9 is unknown; it was probably a short time in Cases 1 and 2, with acute diabetic acidosis, but Case 3 had had diarrhea for over a year, and his increased symptoms had been present for two weeks before his elective hospital admission.
http://www.nejm.org/doi/full/10.1056/NEJM196709212771201
what is the ph of spinal fluid
The pH of spinal fluid is 7.365. The ph of spinal fluid is 7.365.