A compound is known to have a free amino group with a pKa of 8.8, and one other ionizable group with a pKa between 5 and 7. To 100 mL of a 0.2 M solution of this compound at pH 8.2 was added 40 mL of a solution of 0.2 M hydrochloric acid. The pH changed to 6.2.
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E-pharmacophore was generated by using all the default chemical features [hydrogen bond acceptor (A), hydrogen bond donor (D), hydrophobe (H), aromatic ring (R), positive ionizable (P), and negative ionizable (N)] (23).
http://www.thefreedictionary.com/ionizable
ionizable side-chain groups. ionizable side-chain groups. side-chains predominantly of amino acids capable of ionization in aqueous solution depending on pH. Lysine, arginine and histidine have basic ionizable side-chains and aspartate and glutamate have acidic ionizable side-chains.
http://medical-dictionary.thefreedictionary.com/ionizable+side-chain+groups
Adiabatic ionization is a form of ionization in which an electron is removed from or added to an atom or molecule in its lowest energy state to form an ion in its lowest energy state. The Townsend discharge is a good example of the creation of positive ions and free electrons due to ion impact.
https://en.wikipedia.org/wiki/Ionizable
verb (used with object), ionized, ionizing. 1. to separate or change into ions. 2. to produce ions in. verb (used without object), ionized, ionizing. 3. to become changed into the form of ions, as by dissolving.
http://www.dictionary.com/browse/ionizable
This article is about physical processes. For devices, see Ion source. Ionization is the process by which an atom or a molecule acquires a negative or positive charge by gaining or losing electrons to form ions, often in conjunction with other chemical changes.
https://en.wikipedia.org/wiki/Ionizable
The a carbon of most of the amino acids is chiral. Thus there are two stereoisomers of most of the amino acids. Each amino acid has a different side chain (or R group). The side chains vary greatly in their complexity and properties. The side chain of glycine is simply a hydrogen. The side chain of tryptophan is based on the aromatic, bicyclic indole group. Amino acids are classified by the chemical nature of their side chains.
http://webhost.bridgew.edu/fgorga/proteins/aminoacids.htm
The rate of absorption of the drug, and hence exposure, is inextricably linked to the intrinsic dissolution rate, which is governed by properties such as crystallinity and hydrophobicity, and the inherent solubility of the drug molecule, which is driven by factors embedded within the chemical structure, such as the number of ionisable groups and ...
http://www.thefreedictionary.com/ionisable
A true statement about hydrophobic interactions is that they: A) are the driving force in the formation of micelles of amphipathic compounds in water. B) do not contribute to the structure of water-soluble proteins. C) have bonding energies of approximately 20-40 Kjoule per mole.
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Amino acids are organic compounds that consist of a basic amino group and acidic. carboxylic acid moiety. The properties of these individual functional groups are. described in more detail in the Carboxylic Acid and Amine Tutorials. Amino acids of.
http://www.auburn.edu/~deruija/pda1_aminoacids.pdf
what is an ionizable group
 An ionizable group is ionizable side-chains and aspartame and glutamate have acidic ionizable side-chains.