The roles played by LPIN2 and the human homolog of pstpip2, PSTPIP2, in the etiology of chronic recurrent multifocal osteomyelitis are uncertain but are currently being investigated.. The professional theories seem to be moving in the direction of an inherited gene.
https://en.wikipedia.org/wiki/Chronic_recurrent_multifocal_osteomyelitis
The clinical and radiological features on the disease are variable and the diagnosis can be difficult. This disease is rare, and often affects children, more commonly girls than boys. The peak age of incidence is around 10 years, with the range being four to 55 years. Adults can be affected.
http://bonetumor.org/tumors-unknown-type/chronic-recurrent-multifocal-osteomyelitis-crmo
There have been reported associations with multiple auto-immune diseases, including but not limited to peripheral arthri-tis [8, 9], inflammatory bowel disease [3, 26], psoriasis [3, 27], and sacroiliitis [28, 29]. It is possible that CRMO may represent a juvenile form of seronegative spondyloarthropathy [5]. A Fig.
http://www.ajronline.org/doi/pdf/10.2214/AJR.09.7212
CRMO was once considered strictly a childhood disease, but adults have been diagnosed with it. The affected tends to range from 4 to 14 years old, with 10 as the median age. As stated above, CRMO occurs 1:1,000,000 and primarily in girls with a 5:1 ratio.
https://en.wikipedia.org/wiki/Chronic_recurrent_multifocal_osteomyelitis
Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis, uncommon childhood diseases of unknown cause, occurred in three children (two brothers and a female cousin). Their parents are consanguineous, and the clinical course of their illness was similar.
https://en.wikipedia.org/wiki/Chronic_recurrent_multifocal_osteomyelitis
Cutting edge research now classifies CRMO as an inherited autoinflammatory disease but have yet to isolate the exact gene responsible for it. Some specialists believe they have discovered a link between CRMO with a rare allele of marker D18S60, resulting in a haplotype relative risk (HRR) of 18.
https://en.wikipedia.org/wiki/Chronic_recurrent_multifocal_osteomyelitis
Antibiotics also do not alter the course of disease [5]. Previously described isolation of organisms such as Staphylococcus epidermidis and Propionibacterium acne has generally been attributed to sample contamination [7].CRMO has also been hypothesized to be an autoimmune dis-order.
http://www.ajronline.org/doi/pdf/10.2214/AJR.09.7212
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory (NOT autoimmune) disorder that mostly affects children.
http://bonetumor.org/tumors-unknown-type/chronic-recurrent-multifocal-osteomyelitis-crmo
Multiple names have used to describe this entity. These include chronic multifocal osteomyelitis, chronic recurrent multifocal osteomyelitis, and SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis). The cause of this condition is unknown, despite intensive investigation over a period of more than 30 years.
http://bonetumor.org/tumors-unknown-type/chronic-recurrent-multifocal-osteomyelitis-crmo
Dermatological manifestations may occur and include psoriasis, acne, and pustules on the palms of the hands and soles of the feet. Uveitis, and inflammatory bowel disease have also been described. Majeed syndrome consists of CRMO and congenital dyserythropoietic aneama, has been reported in families.
http://bonetumor.org/tumors-unknown-type/chronic-recurrent-multifocal-osteomyelitis-crmo
is crmo an immune disorder
No, Chronic Recurrent Multifocal Osteomyelitis is not an immune disorder. Chronic recurrent multifocal osteomyelitis is not an immune disorder.