An adjunct in monitoring sex-steroid and anti-androgen therapy. An adjunct in the diagnosis of disorders of puberty. An adjunct in the diagnosis and follow-up of anorexia nervosa. An adjunct in the diagnosis of thyrotoxicosis (tissue marker of thyroid hormone excess)
http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9285
Interpretation Provides information to assist in interpretation of the test results. Many conditions of mild-to-moderate androgen excess in women, particularly polycystic ovarian syndrome, are associated with low sex hormone-binding globulin (SHBG) levels. Most of these women are also insulin resistant and many are obese.
http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9285
Globulin is a generic term used to describe a set of sixty proteins including the antibodies or gamma globulins and protein-carbohydrate compounds known as glycoprotein. There are four basic groups of globulin proteins known as the alpha-1, alpha-2, beta and gamma proteins.
http://www.md-health.com/Globulin.html
SHBG levels are typically very low in these individuals. However, in most patients, SHBG levels are mildly depressed or even within the lower part of the normal range. In these patients, the primary problem may be androgen overproduction, insulin resistance, or both.
http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9285
The proper globulin to albumin ratio is 1:2, though this can range from 1.7-2.2 and still remain healthy. If this ratio changes to an extreme level it can cause a number of health concerns. High levels of globulin can be caused by an overproduction of globulin, an underproduction of albumin or a loss of albumin.
http://www.md-health.com/Globulin.html
If your globulin levels are normal you will have a total level of 6.0-8.4 gm/dL of protein in the blood stream. Ideally, this level will fall at 7.5 g/dL. This should be comprised approximately of 3.5-5 gm/dL of albumin and 2.3-3.5 gm/dL of globulin.
http://www.md-health.com/Globulin.html
How is it used? Total protein and albumin tests are routinely included in the panels of tests performed as part of a health examination, such as a comprehensive metabolic panel (CMP), so they are frequently used to help evaluate a person's overall health status.
https://labtestsonline.org/understanding/analytes/tp/tab/test
Additionally, since total protein can be low, increased, or the component globulin proteins altered with many different diseases and disorders, total protein and albumin tests may be ordered in a variety of settings to help diagnose disease, to monitor changes in health status, and as a screen that may indicate the need for various follow-up tests.
https://labtestsonline.org/understanding/analytes/tp/tab/test
Some laboratories report total protein, albumin, and the calculated ratio of albumin to globulins, termed the A/G ratio. The A/G ratio is calculated from measured total protein, measured albumin, and calculated globulin (total protein - albumin). Because disease states affect the relative amounts of albumin and globulin, the A/G ratio may provide a clue as to the cause of the change in protein levels.
https://labtestsonline.org/understanding/analytes/tp/tab/test
The liver produces much of the alpha and beta globulins used for this purpose. The level of these proteins is measured against the levels of albumin, the other major type of protein in the bloodstream. A specific ratio must be met in order to maintain healthy circulatory function. Ratios of globulin compared to albumin can be low or high, and each presents its own dangers.
http://www.md-health.com/Globulin.html
what is the range for globulin,serum
The range for globulin serum is 6.0-8.4 gm/dL. The range for globulin,serum is 6.0 to 8.4 grams per deciliter.