1 Children of a parent with bipolar disorder have a 50% chance of having a major psychiatric illness. 2  Children remain at an increased risk even if they are raised in the home of parents without the illness.
http://www.healthyplace.com/bipolar-disorder/bipolar-information/causes-of-bipolar-disorder-what-causes-bipolar-disorder/
There may be no single cause of bipolar disorder (aka manic depression). Instead, research indicates the causes of bipolar disorder are probably a combination of biochemical, genetic and environmental factors that may trigger and perpetuate the chemical imbalances in the brain.
http://www.healthyplace.com/bipolar-disorder/bipolar-information/causes-of-bipolar-disorder-what-causes-bipolar-disorder/
Researchers have discovered that some people with bipolar disorder have: 1  biochemical imbalances of hormones and certain neurotransmitters in the brain; especially dopamine, serotonin, norepinephrine, and acetylcholine. 2  1. 3  an over-secretion of cortisol, a stress hormone.
http://www.healthyplace.com/bipolar-disorder/bipolar-information/causes-of-bipolar-disorder-what-causes-bipolar-disorder/
A. A. A. Bipolar disorder, also known as manic depression, is an illness in which a person has periods of high mood and energy and other times of depression. People diagnosed with bipolar disorder usually have one or more major depressive episodes along with one or more manic or mixed episodes.
http://www.webmd.com/bipolar-disorder/guide/bipolar-disorder-whos-at-risk
Experts believe bipolar disorder is partly caused by an underlying problem with specific brain circuits and the balance of brain chemicals called neurotransmitters. Three brain chemicals -- noradrenaline (norepinephrine), serotonin, and dopamine -- are involved in both brain and bodily functions.
http://www.webmd.com/bipolar-disorder/guide/bipolar-disorder-causes
Researchers have been investigating whether common biologic factors are involved in the cause of bipolar disorder and schizophrenia, schizoaffective and manic syndromes, as schizophrenic and bipolar disorder are similar in many respects. They share: 2. 1  Age of onset. 2  Lifetime risk. 3  Course of illness.
http://www.healthyplace.com/bipolar-disorder/bipolar-information/causes-of-bipolar-disorder-what-causes-bipolar-disorder/
1 A major distinction among monogenic disorders is between dominant and recessive diseases. 2  Dominant diseases are caused by the presence of the disease gene on just one of the two inherited parental chromosomes. 3  In dominant diseases, the chance of a child inheriting the disease is 50 percent.
https://www.genome.gov/19016930/
In studies of identical twins, scientists report that if one identical twin has bipolar disorder, the other twin has a greater chance of developing bipolar disorder than another sibling in the family.
http://www.webmd.com/bipolar-disorder/guide/bipolar-disorder-causes
Geneticists group genetic disorders into three categories: 1  Monogenetic disorders are caused by a mutation in a single gene. 2  The mutation may be present on one or both chromosomes (one chromosome inherited from each parent).
https://www.genome.gov/19016930/
Other diseases are caused by acquired mutations in a gene or group of genes that occur during a person's life. Such mutations are not inherited from a parent, but occur either randomly or due to some environmental exposure (such as cigarette smoke). These include many cancers, as well as some forms of neurofibromatosis. Genetic disorders typically involve the inheritance of a particular mutated disease-causing gene, such as sickle cell disease, cystic fibrosis, and Tay-Sachs disease.
https://www.genome.gov/19016930/
bipolar what causes the genetic disorder
The genetic bipolar disorder caused by an underlying problem with specific brain circuits and the balance of brain chemicals called neurotransmitters.   The genetic disorder caused by an underlying problem with specific brain circuits and the balance of brain chemicals called neurotransmitters.