Prescription Recommendations. 1  Prescribe: carbidopa/levodopa 25/100 (tablet) 2  Instruct: ½ tab tid for one week, then 1 tab tid and re-evaluate symptoms and patient clinical response at this dose. If symptoms need further treatment then titrate up to 1.5 tab tid for one week, then 2 tab tid.
http://www.toolkit.parkinson.org/content/levodopa
Carbidopa-levodopa is a combination of two drugs, levodopa and carbidopa. Carbidopa-levodopa is used in the treatment of Parkinson's disease. Parkinson's disease is believed to be caused by low levels of dopamine in certain parts of the brain.
https://www.medicinenet.com/levodopa-carbidopa/article.htm
Note: Give levodopa 1 hour prior or 2 hours after meals. Side Effects Nausea, vomiting (take pills on a full stomach to reduce nausea or use domperidone 10-20 mg tid or trimethobenzamide hydrochloride 300 mg up to 4 times daily)
http://www.toolkit.parkinson.org/content/levodopa
Carbidopa is added to the levodopa to prevent the breakdown of levodopa before it crosses into the brain. The addition of carbidopa allows lower doses of levodopa to be used. This reduces the risk of side effects from levodopa such as nausea and vomiting.
https://www.medicinenet.com/levodopa-carbidopa/article.htm
150–1000 mg of levodopa total daily dose (divided 3-4 times) Monotherapy or adjunct therapy for slowness, stiffness, and tremor. Carbidopa/levodopa oral disintegrating (Parcopa) 10/100, 25/100, 25/250. 150–1000 mg of levodopa total daily dose(divided 3-4 times) Same as above, plus need for dissolvable medication in mouth
http://www.toolkit.parkinson.org/content/levodopa
Key Facts. 1  The central objective of using Parkinson’s disease medication is to control or manage motor symptoms. 2  Almost all patients will need levodopa in their management. In general it is recommended that you start with a dopamine agonist if your patient is younger than 50 years; you should consider starting with carbidopa/levodopa if your patient is older than 70 years; either option is good if your patient is between 50 and 70 years old.
http://www.toolkit.parkinson.org/content/levodopa
OR. 1  Prescribe: levodopa/benserazide 50/12.5 (capsule) 2  Instruct: 1 cap tid for one week, then 2 caps tid for one week, then 3 caps tid. 3  Tip: If you encounter nausea add 25-75mg of carbidopa per dose of sinemet or alternatively add domperidone. 4  Levodopa/benserazide and domperidone are not available in the US.
http://www.toolkit.parkinson.org/content/levodopa
Prescribe: carbidopa/levodopa 25/100 (tablet) Instruct: ½ tab tid for one week, then 1 tab tid and re-evaluate symptoms and patient clinical response at this dose. If symptoms need further treatment then titrate up to 1.5 tab tid for one week, then 2 tab tid. (Tip: In general, titrate to severity of symptoms.
http://www.toolkit.parkinson.org/content/levodopa
Carbidopa-levodopa is taken several times per day. It may be administered with food to reduce the likelihood of nausea; however, a high-protein diet may reduce its absorption. The initial dose using regular tablets is 25/100 mg three times daily.
https://www.medicinenet.com/levodopa-carbidopa/article.htm
Levodopa-carbidopa (Sinemet, Sinemet CR, Parcopa) is a combination medication of levodopa and carbidopa prescribed for the treatment of Parkinson's disease. Side effects, dosing, drug interactions, and pregnancy safety should be reviewed prior to taking this medication.
https://www.medicinenet.com/levodopa-carbidopa/article.htm
what does carbidopa levodopa do need to be given at specific times
Give levodopa should be given 1 hour prior or 2 hours after meals.