 Kusumoto Ine ( 楠本 イネ , 31 May 1827 – 27 August 1903 ; born Shiimoto Ine 失本 稲 ) was a Japanese physician . She was the daughter of Kusumoto Taki , who was a courtesan from Nagasaki ; and the German physician Philipp Franz von Siebold , who worked on Dejima , an island foreigners were restricted to during Japan 's long period of isolation .
Ōkubo Toshimichi , leader of the Meiji Restoration , was one of her descendants .
Kusumoto Ine was born in Nagasaki as Shiimoto Ine (失本 稲 ) . She was a daughter of