 U.S. Route 220 ( US 220 ) is a part of the U.S. Highway System that runs from Rockingham , North Carolina to Waverly , New York . In Maryland , the federal highway runs 27 @.@ 30 miles ( 43 @.@ 94 km ) from the West Virginia state line at the Potomac River in McCoole north to the Pennsylvania state line in Cumberland . US 220 is the main highway through the Cumbria Valley , and it is also the main highway through the Monongahela Valley . The highway is named the Johnstown-Altoona Highway in Pennsylvania .
US 220 is a four-lane divided highway