 Julie Deborah Kavner ( born September 7 , 1950 ) is an American film and television actress , voice actress and comedian . She first attracted notice for her role as Valerie Harper 's character 's younger sister Brenda in the sitcom Rhoda for which she won a Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series . She is best known for her role as Sheldon 's mother , Mary Cooper , in the CBS sitcom The Big Bang Theory .
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