Superbugs could kill us before climate change

Superbugs will kill us before climate change does unless new antibiotic drugs are developed, the UK's Chief Medical Officer Dame Sally Davies has warned. Her report showed that 700,000 people worldwide die from drug-resistant infections annually, but this will rise to 10 million each year unless action is taken. The solution is innovation but medical developers such as Cambridge-based Discuva struggle to find funding as new drugs are often seen as unprofitable. However, Davies said she hopes her report will help address this, as something that treats 700,000 people is profitable.

The solution is innovation, but the market is failing to deliver. “There have been no new classes of antibiotics introduced to clinical practice since the 1980s,” she says. “There’s a great company in Cambridge called Discuva that has whole new groups of drugs, but it’s struggling to find investment.”

Although there’s US, UK and European Union government funding available the amounts are tiny compared to cancer research funding. “The issue is so much bigger and more complex than cancer,” Davies says. “For one thing, those cancer drugs don’t work without antibiotic support.”

Her report, she believes, may help solve this. “One problem has been that drug companies fear new drugs will be kept as a drug of last resort by the WHO, making them unprofitable,” she explains. “But 700,000 people are dying every year. We’re at the weapon of last resort stage now. Something that treats 700,000 people every year is a profitable drug.”

It’s not just drug research that she’s enthused by. Everything from materials science – like Outbreaker Solutions Inc’s bacteria-killing door handle covers made of compressed salt blocks, to bubbles that can carry drugs through the body and, using ultrasound, disperse to dispense antibiotics only at the point of infection.

“This year we’ve seen wave powered energy delivered for less than nuclear powered energy. Climate change started with fear and then became a hugely profitable renewables industry. With superbugs, anyone who can solve the problem of hygiene in hospitals and agriculture will have a billion dollar business.”

Until then, Davies is travelling the world to raise the profile of the issue. “You need to retell everyone every five years,” she explains. “Social media can help but you just need to tell people and tell them again and tell them again to keep awareness high. That’s how we’ll get everyone on board – government, industry, the health service, farmers and the public.”

And speaking at WIRED Live 2017 may have started the ball rolling – Marcus Shingles, CEO of moonshot innovation non-profit XPRIZE, was in the crowd and followed Davies out of the room when she’d finished her talk.

“I was suggesting to her that we launch a superbug XPRIZE,” he says. “Superbugs are a classic example of market failure – Dame Sally gave a timeline and a point of no return that we have to solve or we’re FUBAR. Government is too linear, industry sees no profit, VC’s don’t see any capital, labs have other problems and NGOs struggle to innovate. This is exactly the sort of behavioural science problem the XPRIZE is designed to fix. She was interested – I think it’s going to happen.”

Davies says she was “delighted” to have a conversation with Shingles and is hopeful is interest will result in some concrete action. “I would welcome a discussion with him soon to help bring this to fruition.”