antibiotic-arsenal definition
The escalating rates of microbial resistance in general and the increased resistance of P. aeruginosa to several different classes of antimicrobial agents in particular raise global healthcare and public health concerns [72,203]. Any of a group of broad-spectrum antibiotics, such as streptomycin, derived from species of Streptomyces or Micromonospora bacteria and used to treat infections caused by gram-negative bacteria. The aminoglycosides are potent nephrotoxins, in part because of the high concentrations they attain in the proximal tubular cells (PTCs)--up to 10% of the total parenteral dose may be concentrated in these cells. We evaluated the ototoxic effect of aminoglycosides on the outer hair cells of newborns in a neonatal intensive care unit (NICU) by means of distortion-product otoacoustic emissions (DPOAE) testing. The understanding of this prevalence and the mechanisms of antimicrobial resistance by P. aeruginosa is important in optimizing treatments against pseudomonal infections. P. aeruginosa, commonly known as ‘the blue pus organism’, is a versatile, non-fermentative, and aerobic non-enteric Gram-negative bacterial pathogen. 1 Coughing or sneezing can spread these germs through microscopic droplets in the air. The current recommendation is to cover your mouth with your arm, sleeve, or crook of the elbow, rather than using your hands.  Get vaccinated. Your immune system is designed to have a “memory” of previous infections. 1 By being smart about safe sex (using condoms), transfer of infectious bacteria or viruses from one person to another can be prevented.  Don’t pick your nose (or your mouth or eyes either). Not only is it a social taboo, but it also leads to the spread of a number of infections. Look around, and you’ll notice how many people have their hands next to their faces. Many microbes prefer the warm, moist environment inside your nose, as well as other mucous-covered surfaces such as your eyes and mouth. Infections can be easily prevented by avoiding touching of these areas. 21.10.5 pro-vitamins and hormones, glycosides and vegetable alkaloids and their derivatives, antibiotics. Aminoglycosides, which include streptomycin and gentamicin, are widely used to treat serious infections and sepsis, a deadly condition marked by the immune system going into overdrive. Among the most powerful weapons in our antibiotic arsenal are aminoglycosides, which can prevent the biosynthesis of key proteins that infectious bacteria such as Staphylococcus aureus and Escherichia coli need to survive. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors in the emergence of antimicrobial-resistant bacterial strains, including multidrug-resistant variants. Pseudomonas aeruginosa is a leading cause of nosocomial infections.
They are aminoglycosides, which can prevent the biosynthesis of key proteins that infectious bacteria.