antibody screen test is also known as what
The patient’s blood cells are also treated with anti-D antibodies to determine Rh. Screen. Antibody Screen (the “Screen”): The purpose of this test (also known as the indirect Coombs test) is to detect the presence of the most common antibodies in the patient’s serum. Essentially, the patient’s serum is mixed with red cells of known antigenic composition. It is also used in antenatal screening to detect the presence of antibodies in a pregnant woman's serum that could result in hemolytic disease of the fetus and newborn. Antibody screening may be performed in advance of a crossmatch to permit early recognition and identification of clinically significant antibodies and thereby permit selection of the appropriate crossmatch procedure and RBC units. The antibody screening test performed in a clinical laboratory and/or blood bank is designed to detect the presence of unexpected antibodies, especially alloantibodies in the serum to antigens of the non-ABO blood group system: Duffy, Kell, Kidd, MNS, P, and certain Rh types that are considered clinically significant. Antibody screening consists of testing the recipient's plasma against the RBCs of 2 or 3 reagent screening cells that are licensed by the Food and Drug Administration (FDA). The screening cells must be type O with certain profiles for the following antigens: D, C, E, c, e, K, k, Fy a, Fy b, Jk a, Jk b, M, N, S, s, P 1, Le a, and Le b. Antibody Screening - Test Interpretation. 1  If the screening result is positive in any of the 3 phases with any of the screening cells, additional tests must be performed to identify the specificity of the antibody. As a result, antigen-negative blood is given to the patient for safe transfusion. The patient’s blood cells are also treated with anti-D antibodies to determine Rh. Screen Antibody Screen (the “Screen”): The purpose of this test (also known as the indirect Coombs test) is to detect the presence of the most common antibodies in the patient’s serum. Essentially, the patient’s serum is mixed with red cells of known antigenic composition. Test Interpretation. If the screening result is positive in any of the 3 phases with any of the screening cells, additional tests must be performed to identify the specificity of the antibody. As a result, antigen-negative blood is given to the patient for safe transfusion. The type and screen determines both the ABO-Rh of the patient and screens for the presence of the most commonly found unexpected antibodies. Type ABO-RH testing (the “Type”): The patient’s blood cells are mixed with serum known to have antibodies against A and against B to determine blood type. Antibody Screening - Test Interpretation. 1  If the screening result is positive in any of the 3 phases with any of the screening cells, additional tests must be performed to identify the specificity of the antibody. 2  In a negative reaction, the pellet passes easily to the bottom, as no agglutination occurs. The antibody screening test, as part of pretransfusion compatibility testing (see Miscellaneous), along with the type and crossmatch, prevents transfusion reactions such as hemolysis from occurring. 1  Next: Clinical Indications/Applications. 2  Next: Clinical Indications/Applications. 3  Next: Clinical Indications/Applications.
Antibody screen test is also known as the indirect Coombs test.