amyloidosis definition
amyloidosis - a disorder characterized by deposit of amyloid in organs or tissues; often secondary to chronic rheumatoid arthritis or tuberculosis or multiple myeloma. illness, sickness, unwellness, malady - impairment of normal physiological function affecting part or all of an organism. amyloidosis in Medicine. amyloidosis am·y·loid·o·sis (ām'ə-loi-dō'sĭs) n. A disorder marked by the deposition of amyloid in various organs and tissues of the body that may be associated with a chronic disease such as rheumatoid arthritis, tuberculosis, or multiple myeloma. Amyloidosis is a rare and serious disease caused by accumulation of proteins in the form of abnormal, insoluble fibres, known as amyloid fibrils, within the extracellular space in the tissues of the body. Secondary amyloidosis (AA) is caused by the inflammatory disease process that is part of the underlying disease. Approximately 50% of the people with secondary amyloidosis have rheumatoid arthritis as the underlying disease. Amyloidosis is a systemic disorder that is classified into several types. The different types of systemic amyloidosis are classified as primary, secondary or familial (hereditary). Primary amyloidosis (also called AL, or ‘light chain’) is the most common type of systemic amyloidosis. AL results from an abnormality (dyscrasia) of plasma cells (a type of white blood cell) in the bone marrow and is closely related to multiple myeloma. This is the most common type of amyloidosis. Systemic means it affects the entire body. The most commonly affected body parts are the kidney, heart, liver, intestines, and certain nerves. AL stands for amyloid light chains, which is the type of protein responsible for this type of amyloidosis. Any of a group of diseases or conditions characterized by the formation and deposition of amyloid in various organs and tissues of the body. (ˌæmɪlɔɪˈdəʊsɪs) n. (Pathology) pathol the deposition of amyloid in various tissues of the body, as occurs in certain chronic infections. Definition of amyloidosis. : a disorder characterized by the deposition of amyloid in bodily organs and tissues. In contrast to the normally efficient clearance of abnormal debris from the tissues, amyloid deposits are removed very slowly, if at all. There are many different types of amyloidosis, each caused by formation of amyloid fibrils from different soluble precursor proteins in different patients. In this Article. Amyloidosis is a condition in which an abnormal protein called amyloid builds up in your tissues and organs. When it does, it affects their shape and how they work. Amyloidosis is a serious health problem that can lead to life-threatening organ failure.
Amyloidosis is a rare and serious disease caused by accumulation of proteins in the form of abnormal, insoluble fibres, known as amyloid fibrils, within the extracellular space in the tissues of the body.