anticholinergic effects of haldol
Anticholinergic properties of antipsychotic drugs and their relation to extrapyramidal side-effects. Sayers AC, Bürki HR, Ruch W, Asper H. The effects of haloperidol, alone and in combination with atropine, were compared with the effects of clozapine, alone and in combination with physostigmine, in a variety of tests commonly used to characterize neuroleptic compounds. Contraindications. 1  Pre-existing coma, acute stroke. 2  Severe intoxication with alcohol or other central depressant drugs. 3  Known allergy against haloperidol or other butyrophenones or other drug ingredients. 4  Known heart disease, when combined will tend towards cardiac arrest. Haloperidol often causes troublesome adverse effects. If there is no other antipsychotic drug, using haloperidol to offset the consequences of untreated schizophrenia is justified. Where a choice of drug is available, however, an alternative antipsychotic with less likelihood of adverse effects such as parkinsonism, akathisia and acute dystonias may be more desirable. Haloperidol - Overdose. 1  Symptoms are usually due to side effects. 2  Severe extrapyramidal side effects with muscle rigidity and tremors, akathisia, etc. 3  Hypotension or hypertension. 4  Anticholinergic side effects (dry mouth, constipation, paralytic ileus, difficulties in urinating, decreased perspiration) Haloperidol, marketed under the trade name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, nausea and vomiting, delirium, agitation, acute psychosis, and hallucinations in alcohol withdrawal. It may be used by mouth, as an injection into a muscle, or intravenously. Anticholinergic side effects such as: (These adverse effects are more common than with lower-potency typical antipsychotics, such as chlorpromazine and thioridazine.) Blurred vision; Constipation; Dry mouth; Somnolence (which is not a particularly prominent side effect, as is supported by the results of the aforementioned meta-analysis.) In fact, some effects of haloperidol (catalepsy) were antagonized by atropine, while others (induction of striatal DA-receptor hypersensitivity) were enhanced. Haloperidol typically works within thirty to sixty minutes. A long-acting formulation may be used as an injection every four weeks in people with schizophrenia or related illnesses, who either forget or refuse to take the medication by mouth. Haloperidol may result in a movement disorder known as tardive dyskinesia which may be permanent. Haloperidol is used to treat certain mental/mood disorders (e.g., schizophrenia, schizoaffective disorders). This medicine helps you to think more clearly, feel less nervous, and take part in everyday life. It can also help prevent suicide in people who are likely to harm themselves. It also reduces aggression and the desire to hurt others. It can decrease negative thoughts and hallucinations. Symptoms are usually due to side effects. 1  Most often encountered are: 2  Severe extrapyramidal side effects with muscle rigidity and tremors, akathisia, etc. 3  Hypotension or hypertension. 4  Sedation. 5  Anticholinergic side effects (dry mouth, constipation, paralytic ileus, difficulties in urinating, decreased perspiration)
Anticholinergic side effects such as Blurred vision, Constipation, Dry mouth and Somnolence.