antitrypsin definition
Check your grammar now! : a trypsin-inhibiting serum protein which inhibits the digestive action of elastase on the tissues of the lungs and whose deficiency is associated with the development of emphysema—abbreviation AAT. Alpha-1 antitrypsin (AAT) is a protein that is made in the liver. The liver releases this protein into the bloodstream. AAT protects the lungs so they can work normally. Without enough AAT, the lungs can be damaged, and this damage may make breathing difficult. Currently extracted from human blood serum, alpha-1 antitrypsin is used to treat people who risk life-threatening emphysema because of an inherited deficiency of the enzyme. Alpha-1 antitrypsin deficiency (AATD) is an inherited condition that causes low levels of, or no, alpha-1 antitrypsin (AAT) in the blood. AATD occurs in approximately 1 in 2,500 individuals. Medical Definition of alpha–1–antitrypsin. : a trypsin-inhibiting serum protein which inhibits the digestive action of elastase on the tissues of the lungs and whose deficiency is associated with the development of emphysema—abbreviation AAT. Treatment of alpha-1 antitrypsin deficiency (AATD) is based on a person's symptoms. There is currently no cure. The major goal of AATD management is preventing or slowing the progression of lung disease. Recommendations for expensive treatments made for a genetic disorder called alpha-1 antitrypsin deficiency should be withdrawn because the drugs have no benefit, scientists said. Alpha 1 proteinase inhibitor is intended for therapy of congenital alpha 1 antitrypsin deficiency, which leads to emphysema. Alpha-1 Antitrypsin Deficiency (Alpha-1) is a genetic (inherited) condition – it is passed from parents to their children through their genes. Alpha-1 may result in serious lung disease in adults and/or liver disease at any age. For each trait a person inherits, there are usually two genes; one gene comes from each parent. The mission of the Alpha-1 Foundation is to provide the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency. Alpha-1 antitrypsin deficiency (AAT deficiency) is an inherited condition that raises your risk for lung and liver disease. Alpha-1 antitrypsin (AAT) is a protein that protects the lungs. The liver makes it. If the AAT proteins aren't the right shape, they get stuck in the liver cells and can't reach the lungs.
A trypsin-inhibiting serum protein which inhibits the digestive action of elastase on the tissues of the lungs and whose deficiency is associated with the development of emphysema—abbreviation AAT.