alb/cr ratio
The albumin-creatinine ratio in early morning spot urine collected on awakening (before breakfast or exercise) is considered as a valid test for albumin excretion in urine. It is simple and inexpensive; it does not require a timed 24-hour collection of urine; and, most importantly, it gives a quantitative result that correlates well with 24-hour urine values over a wide range of protein excretion. Associations/Indications. 1  marker of vascular endothelial dysfunction. 2  an important prognostic marker for kidney disease in diabetes mellitus. in hypertension. In medicine, the BUN-to-creatinine ratio is the ratio of two serum laboratory values, the blood urea nitrogen and serum creatinine. Outside the United States, particularly in Canada and Europe, the truncated term urea is used and the units are different. The units of creatinine are also different, and this value is termed the urea-to-creatinine ratio. The ratio may be used to determine the cause of acute kidney injury or dehydration. The principle behind this ratio is the fact that both urea and Your doctor may order the microalbuminuria test if you have one of these conditions. The purpose of the microalbuminuria test is to measure the amount of albumin in the urine. The test is typically used in conjunction with a creatinine test to provide an albumin-to-creatinine ratio. Creatinine is a waste product in the blood that your kidneys should remove. When kidney damage occurs, creatinine levels in the urine decrease while albumin levels may increase. Doing a 24-hour urine collection for proteinuria and creatinine clearance is unnecessary because a spot urine sample to measure urine albumin to creatinine ratio is quite sufficient for diagnosis and therapy. More importantly, exercise, dietary protein, and sustained upright posture tend to increase albumin excretion rates. A ratio of albumin (mcg/L) to creatinine (mg/L) of less than 30 is normal; a ratio of 30-300 signifies microalbuminuria and values above 300 are considered as macroalbuminuria. On a standard urine dipstick, 10-20 mg/dL is the minimal detection limit of protein. If the dipstick is positive, then the patient likely has microalbuminuria. The ratio is predictive of prerenal injury when BUN:Cr exceeds 20 or when urea:Cr exceeds 100. In prerenal injury, urea increases disproportionately to creatinine due to enhanced proximal tubular reabsorption that follows the enhanced transport of sodium and water. BUN-to-creatinine ratio - Definition. [ 1 1] Urea and creatinine are nitrogenous end products of metabolism. 2  The normal range of urea nitrogen in blood or serum is 5 to 20 mg/dl, or 1.8 to 7.1 mmol urea per liter. 3  The normal serum creatinine (sCr) varies with the subject's body muscle mass and with the technique used to measure it. Renal damage causes reduced reabsorption of BUN, therefore lowering the BUN:Cr ratio. An elevated BUN:Cr due to a low or low-normal creatinine and a BUN within the reference range is unlikely to be of clinical significance. In medicine, the BUN-to-creatinine ratio is the ratio of two serum laboratory values, the blood urea nitrogen (BUN) (mg/dL) and serum creatinine (Cr) (mg/dL). Outside the United States, particularly in Canada and Europe, the truncated term urea is used (though it is still the same blood chemical) and the units are different (mmol/L).
The albumin-creatinine ratio in early morning spot urine collected on awakening (before breakfast or exercise) is considered as a valid test for albumin excretion in urine.