________ are fixed macrophages found in the liver.
immune system. in immune system: Macrophages. The other main type of scavenger cell is the macrophage, the mature form of the monocyte. Like granulocytes, monocytes are produced by stem cells in the bone marrow and circulate through the blood, though in lesser numbers. An important cell in the immune system. Macrophages are scavenging cells, large PHAGOCYTES derived from blood MONOCYTES, and are found all over the body, especially in the liver, lymph nodes, spleen and bone marrow. Some are stationary within the tissues (fixed macrophages), others are free and move about, being attracted to sites of infection. Connective tissue (fixed) macrophages are called histiocytes; those in the liver are called Kupffer cells; and those in the nervous system are called microglial cells. Medical Definition of Macrophage. Macrophage: A type of white blood cell that ingests foreign material. Macrophages are key players in the immune response to foreign invaders of the body, such as infectious microorganisms. They are normally found in the liver, spleen, and connective tissues of the body. Last Editorial Review: 5/13/2016. Kupffer cell. Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized macrophages located in the liver, lining the walls of the sinusoids that form part of the mononuclear phagocyte system. Contents. Another important feature of hepatic sinusoids is that they house an important part of the phagocytic system. Sinusoids are populated by numerous Kupffer cells, a type of fixed macrophage. Identifying Kupffer cells in conventionally-stained sections of liver is not easy. Phagocytic cells form a part of the lining of blood vessels, particularly in the spleen, liver, and bone marrow. These cells, called macrophages, are constituents of the reticuloendothelial system and are found in the lymph nodes, in the intestinal tract, and as free-wandering and fixed cells. In addition, the body has macrophages already stationed throughout the tissues and organs of the body. These are sometimes referred to as fixed macrophages. Many fixed macrophages are part of the mononuclear phagocytic (reticuloendothelial) system. They, along with B-lymphocytes and T-lymphocytes, are found supported by reticular fibers in lymph nodules, lymph nodes , and the spleen where they filter out and phagocytose foreign matter such as microbes. fixed mac·ro·phage. a relatively immotile macrophage found in connective tissue, lymph nodes, spleen, and bone marrow. fixed macrophage. a nonmotile mononuclear phagocyte found in connective tissue, liver sinuses, spleen, lymph glands, and bone marrow. fixed macrophage. Etymology: L, figere, to fasten; Gk, makros, large, pagein, to eat. a nonmotile mononuclear phagocyte found in connective tissue, liver sinuses, spleen, lymph glands, and bone marrow. Similar cells derived from stem cells, monocytes, or macrophages are also found in the liver (Kupffer cells), the kidneys (mesangial cells), the brain (microglia), the bones (osteoclasts), the lungs (alveolar macrophages), and the gastrointestinal tract (peritoneal macrophages).
Kupffer cells