amoxicillin dosing pediatrics
Dosage in patients with impaired renal function: The dose should be reduced in patients with severe renal function impairment. In patients with a renal clearance of less than 30 ml/min an increase in the dosage interval and a reduction in the total daily dose is recommended (see section 4.4 and 5.2). Family Practice Pearls. The Rule of 20 for Pediatric Amoxicillin Dosing. The Rule of 6 for dosing amoxicillin, which we discussed in a previous post, is probably outdated since amoxicillin is typically dosed 80 to 90 mg/kg/day instead of 40 mg/kg/day for children (max 1000 mg per dose). So lets update this rule. Dosing was at the start of a light meal following an overnight fast. Orally administered doses of Amoxicillin Suspension, 125 mg/5 mL and 250 mg/5 mL, result in average peak blood levels 1 to 2 hours after administration in the range of 1.5 mcg/mL to 3 mcg/mL and 3.5 mcg/mL to 5 mcg/mL, respectively. 3 DOSAGE FORMS AND STRENGTHS. for Oral Suspension:125 mg/5 mL, 200 mg/5 mL, 250 mg/5 mL, 400 mg/5 mL. Each 5 mL of reconstituted fruity flavored suspension contains 125 mg, 200 mg, 250 mg or 400 mg Amoxicillin as the trihydrate. Antibiotic therapy should be prescribed for children with acute bacterial sinusitis with severe or worsening disease. Amoxicillin or amoxicillin/clavulanate remain first-line therapy. Recommendations for treatment of children with a history of type I hypersensitivity to penicillin vary. In children who are vomiting or who cannot tolerate oral medication, a single dose of ceftriaxone can be used and then can be switched to oral antibiotics if improving.1. Triple therapy: The recommended adult oral dose is 1 gram Amoxicillin, 500 mg clarithromycin, and 30 mg lansoprazole, all given twice daily (every 12 hours) for 14 days. Dual therapy: The recommended adult oral dose is 1 gram Amoxicillin and 30 mg lansoprazole, each given three times daily (every 8 hours) for 14 days. The table below summarizes the most recent principles of appropriate antibiotic prescribing for children obtaining care in an outpatient setting for the following six diagnoses: acute rhinosinusitis, acute otitis media, bronchiolitis, pharyngitis, common cold, and urinary tract infection. Children's dosage (under 40 kg) The daily dosage for children is 40 - 90 mg/kg/day in two to three divided doses* (not exceeding 3 g/day) depending on the indication, the severity of the disease and the susceptibility of the pathogen (see special dosage recommendations below and sections 4.4, 5.1 and 5.2). Dose according to adult recommendations. Because of the different amoxicillin-to-clavulanate ratios in the 250-mg tablet (amoxicillin 250 mg, clavulanate125 mg) and the 250-mg chewable tablet (amoxicillin 250 mg, clavulanate 62.5 mg), the 250-mg tablet should not be used if the pediatric patient weighs <40 kg. Dosing Considerations. Because of the different amoxicillin-to-clavulanate ratios in the 250-mg tablet (amoxicillin 250 mg, clavulanate125 mg) and the 250-mg chewable tablet (amoxicillin 250 mg, clavulanate 62.5 mg), the 250-mg tablet should not be used if the pediatric patient weighs <40 kg.
80 to 90 mg/kg/day instead of 40 mg/kg/day for children (max 1000 mg per dose).