___ is defined as the death and disintegration of cells and tissue
Spontaneous lysis of cells and tissues caused by the release of lysosomal enzymes. Autolysis is a characteristic postmortem finding and is present in an increasing number of tissues as the body “ages”. Autolysis first appears in the pancreas, which is related to the quantity of hydrolytic enzymes in the pancreas. Necrosis, death of a circumscribed area of plant or animal tissue as a result of an outside agent; natural death of tissue is called necrobiosis. Necrosis may follow a wide variety of injuries, both physical (cuts, burns, bruises) and biological (effects of disease-causing agents). The sign of necrosis—dead tissue—is called a lesion; it is often of diagnostic value. (aw-tol'i-sis), 1. Enzymatic digestion of cells (especially dead or degenerate) by enzymes present within them (autogenous). 2. Destruction of cells as a result of the presence of a lysin formed in those cells or others in the same organism. Cell Death – Apoptosis and Necrosis 3. 1.2 Differences between necrosis and apoptosis. There are many observable morphological (Figure 1, Table 1) and biochemical differ-. ences (Table 1) between necrosis and apoptosis2. Due to the ultimate break-. down of the plasma membrane, the cytoplasmic contents including lysosomal enzymes. are released into the extracellular fluid. Therefore, in vivo, necrotic cell death is often. associated with extensive tissue damage resulting in an intense inflammatory response 5. Apoptosis, in contrast, is a mode of cell death that occurs under normal physiological. conditions and the cell is an active participant in its own demise (“cellular suicide”). It is. most often found during normal cell turnover and tissue homeostasis, embryogenesis, The destruction of tissues or cells by substances, such as ENZYMES, present in the same body. the breakdown of tissues, usually after death, by their own enzymes. enzymic degradation of degenerate cells, e.g. the conversion of skin cells to keratin. the disintegration of cells or tissues by endogenous enzymes. in physiology, a structural or biochemical change in an organ or tissue produced by disease processes or a wound. The alteration may be associated with particular symptoms of a disease, as when a gastric ulcer produces stomach pain, or it may take place without producing symptoms, as in the early... The response mechanisms triggered by. necrotic cell death are particularly complex in sepsis. Since. even sterile cell death induces inﬂammation, a combination. of bacterial stimuli and host stimuli, even those elicited in. sterile sites, may be implicated in the inﬂammatory. response during a septic event. In recent years, a crescendo of. attention has been directed to the mechanisms of cell death. that develop during this disease, since these are viewed as. important contributors to the proinﬂammatory and anti-. inﬂammatory responses associated with poor outcome. 1 heart attack (in cardiovascular disease: Myocardial infarction) 2  spider bite (in spider (arachnid): Venom) 3  traumatic brain injury (in traumatic brain injury: Secondary injury) 4  HealthLink - Necrosis. 5  Mayo Clinic.com - necrosis.  MedicineNet.com - Necrosis.
Necrosis