are nmda receptors involved in central sensitization
Compared with the control rats, the firing rate of spontaneous discharges in ARC neurons of inflamed rats was significantly higher, and it was significantly reduced both by an NMDA receptor antagonist (MK-801, 300 μmol/L) and by a non-NMDA receptor antagonist (CNQX, 30 μmol/L). What is central sensitization? Central sensitization is a condition of the nervous system that is associated with the development and maintenance of chronic pain. When central sensitization occurs, the nervous system goes through a process called “wind-up” and gets regulated in a persistent state of high reactivity. Activation of the NMDA receptor is responsible for the development of central sensitization, hyperalgesia, and allodynia and NMDA receptor antagonists are known to be anti-hyperalgesic, thus useful for chronic pain. One such drug would be Amantadine. ... If it is considered just the central sensitization, the most used medicines are the ones to enhance the central inhibitory descending pathways such the triciclics and duals anti-depressives and, on the other way ,the modulatory drugs of the ascending pathways, such the pregabalin and gabapentin. The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function. The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is named this because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. REVIEW ARTICLE. The Role of N-Methyl-D-Aspartate (NMDA) Receptors in Pain: A Review. Andrei B. Petrenko, MD, Tomohiro Yamakura, MD, PhD, Hiroshi Baba, MD, PhD, and. Koki Shimoji, MD, PhD, FRCA. From the Department of Anesthesiology, Niigata University School of Medicine, Asahimachi 1–757, Niigata 951–8510, Japan. However, NMDA receptors may also. mediate peripheral sensitization and visceral pain. NMDA receptors are composed of NR1, NR2 (A, B, C, and D), and NR3 (A and B) subunits, which determine. the functional properties of native NMDA receptors. Among NMDA receptor subtypes, the NR2B subunit-. We investigated the function of the NR1 subunit of the NMDA receptor and neuronal activation in ARC in mediobasal hypothalamic slices from rats suffering from peripheral inflammatory injury. We found that peripheral inflammation enhanced NR1 phosphorylation and increased neuronal activation in ARC. Glutamate is a major excitatory neurotransmitter in the central nervous system (CNS). The receptors for glutamate comprise two large families: the ionotropic glutamate receptors (iGluRs) and the metabotropic glutamate receptors (mGluRs). Central sensitization involves specific changes to the nervous system. Changes in the dorsal horn of the spinal cord and in the brain occur, particularly at the cellular level, such as at receptor sites. As stated above, it has long been known that strokes and spinal cord injuries can cause central sensitization.
Yes, Activation of the NMDA receptor is responsible for the development of central sensitization.