age adjusted psa values
Your psa is high for your age. Probably in the top 1-2% of all people your age. So it is worth paying attention. On the other hand, the downward trend in your psa test results does not seem to be consistent with a cancerous process. If I were you, I would first take a course of antibiotics and then re-test the psa. I went for my annual physical (49yo) and my PSA test came back high-5.83. My general doc sent me to an urologist and he promptly recommended a biopsy. In the six months since I said no, my PSA has dropped. I have been a cyclist for 25 plus years averaging 8,000 miles a year. Refinements in the interpretation of PSA density calculation have been attempted, such as consideration of the volume of the transition zone[21]; volume-referenced PSA values[29]; and an unpublished study of age-specific PSA density. Although previous thresholds such as 2.5 and 4.0 ng/mL have been used in the past, the AUA now recommends that the decision to biopsy should take into account the patient’s DRE results, age, ethnicity, comorbidities, and prior biopsy history in addition to their serum PSA level. Prostate-specific antigen levels correlated with age (r = .43 [r² = 18.5]; P less than .0001); a higher correlation of PSA with PSA density was found (r = .55; P less than .0001); and PSA density was weakly correlated with age (r = .25; P = less than .001). Recent data has redefined the way that urologists look at PSA, and what is considered a normal PSA. Age-adjusted PSA values take into account that a 40-year-old should not have the same PSA as an 80-year-old. Accepted age-adjusted PSA rates are below 2.4 ng/ml for men under the age of 50 and 6.5 ng/ml for patients in their 70s. Other limits have been defined for varying age ranges, but there is not universal agreement about the accuracy of the age-adjusted levels. ABSTRACT: An association between age and prostate-specific antigen (PSA) has been documented: As men age, their serum PSA value increases. Currently, a single demarcation between normal and elevated PSA values, 4.0 ng/mL, is used as an indication for biopsy among men of all ages. The use of age-specific reference ranges might address several shortcomings of the PSA test. Tell a friend about us, add a link to this page, or visit the webmaster's page for free fun content. Link to this page: <a href=http://medical-dictionary.thefreedictionary.com/Age+Adjusted+PSA>Age Adjusted PSA</a>. A landmark analysis,[31] based on the Baltimore Longitudinal Study of Aging, demonstrated a significant difference in the age-adjusted rate of change in PSA levels among groups of men who had prostate cancer, BPH, and no prostate disease. In order to increase the efficacy of serum PSA interpretation, a number of performance variables are used clinically. These include age-adjusted PSA, density, velocity, and the free-to-complexed PSA ratio. Age Adjusted PSA: Since PSA normally rises with age, age-adjusted thresholds have been described. Benign growth of the prostate that normally occurs with age is the most common cause of PSA elevation. Roughly 70% of patients with an elevated PSA level between 4 and 10 will have a negative prostate biopsy. Conversely, there is no level of PSA at which you can guarantee a patient that they do not have cancer. Moreover, the absolute PSA level does not predict whether or not prostate cancer is harmful.
Below 2.4 ng/ml for men under the age of 50 and 6.5 ng/ml for patients in their 70s.