antidepressants that can cause hyponatremia
Antipsychotic drugs: Phenothiazines (thioridazine, trifluperazine), butyrophenones (haloperidol). Antidepressant and antipsychotic drugs cause hyponatremia through the development of SIADH. Antiepileptic drugs: Carbamezepine, oxcarbazepine, sodium valproate, lamotrigine. Carbamazepine, oxcarbazepine and sodium valproate cause an increase in production of ADH, whereas carbamazepine and lamotrigine cause potentiation of ADH effect. Antidepressant for neuropathy pain leads to hyponatremia. A 72-year-old patient with chronic kidney disease, diabetes, and diabetic neuropathy came to our office. He was complaining to his family practice office about the pain in his feet. He was an avid golfer at an army base and was only able to play 18 holes a day. Antidepressant-induced hyponatraemia can cause significant morbidity, complications and mortality. It is mostly associated with the use of SSRIs, but its frequency and class-specificity are uncertain. Hyponatremia is a potentially dangerous side effect of. antidepressants and is not exclusive to SSRIs. Current. evidence suggests a relatively higher risk of hyponatremia. with SSRIs and venlafaxine, especially when combined. withpatientriskfactors,warrantingclinicianstobeaware. the MPR take: Hyponatremia can be a potentially dangerous side effect of certain antidepressant medications. In a recent study published in the journal Psychosomatics, researchers review the incidence and odds ratios for hyponatremia based on antidepressant class. To the Editor: There are numerous reports of hyponatremia associated with selective serotonin-reuptake inhibitors (SSRIs),1 with at least 35 reports involving citalopram (Celexar, Forest).2 However, there have been few reported cases of hyponatremia associated with escitalopram (Lexapro, Forest),2 making it difficult to confirm the association. Drugs that cause hyponatremia include: 1  Diuretics: Thiazides, bumetanide, indapamide, ethacrynic acid, furosemide. 2  Antidepressants: Selective serotonin reuptake inhibitors, tricyclic antidepressants (amitriptyline, protriptyline, desipramine), monoamine oxidase inhibitors, venlafaxine. Hyponatremia and SSRIs. Hyponatremia (serum sodium <135 mmol/L) occasionally is associated with selective serotonin reuptake inhibitors (SSRIs) (BTP 1998;21:50, 1997;20:8, 1996;19:15-16). Elderly patients appear to be at greatest risk. However, the lack of food meant that he had increased his water intake, leading to hyponatremia. All SNRIs and selective serotonin reuptake inhibitors (SSRIs) can cause hyponatremia. The mechanism of action is thought to be via syndrome of inappropriate antidiuretic hormone (SIADH), which impairs water excretion. Review Articles. Antidepressants and the Risk of Hyponatremia: A Class-by-Class Review of Literature. Livia De Picker, M.D., Filip Van Den Eede, M.D., Ph.D., Glenn Dumont, Ph.D., Greta Moorkens, M.D., Ph.D., Bernard G.C. Sabbe, M.D., Ph.D. Background: Antidepressant-induced hyponatremia. can cause signiﬁcant morbidity and mortality. It is.
Tricyclic