an autoreceptor is located on the _________ and is sensitive to ____________
A neurotransmitter receptor located in the presynaptic terminal of the same neuron that produces the neurotransmitter. Autoreceptors have a higher affinity for the neurotransmitter than does the postsynaptic receptor, and thus have an autoregulatory function. au·to·re·cep·tor. An autoreceptor is a receptor located on presynaptic nerve cell terminals and serves as a part of a feedback loop in signal transduction. It is sensitive only to those neurotransmitters or hormones that are released by the neuron in whose membrane the autoreceptor sits. Canonically, a presynaptic neuron releases the neurotransmitter across a synaptic cleft to be detected by the receptors on a postsynaptic neuron. An autoreceptor will detect this neurotransmitter from its position on the presynaptic membrane. IN is also observed in DA neurons, and it activates at the same thresholds as IL, but it requires prior hyperpolarization of the membrane (to -90 mV) and is w-conotoxin-sensitive. Both IL and IN, but not IT, are reduced by stimulation of the DA autoreceptor (). A given receptor can act as either an autoreceptor or a heteroreceptor, depending upon the type of transmitter released by the cell on which it is embedded. Autoreceptors may be located in any part of the cell membrane: in the dendrites, the cell body, the axon, or the axon terminals. An autoreceptor is a receptor located on presynaptic nerve cell terminals and serves as a part of a feedback loop in signal transduction. It is sensitive only to those neurotransmitters or hormones, that are released by the neuron in whose membrane the autoreceptor sits. Canonically, a presynaptic neuron releases the neurotransmitter across a synaptic cleft to be detected by the receptors on a postsynaptic neuron. An autoreceptor will detect this neurotransmitter from its position on the presynaptic membrane. A neurotransmitter receptor located in the presynaptic terminal of the same neuron that produces the neurotransmitter. Autoreceptors have a higher affinity for the neurotransmitter than does the postsynaptic receptor, and thus have an autoregulatory function. (aw'tō-rĕ-sep'tŏr) From Wikipedia, the free encyclopedia. An autoreceptor is a type of receptor located in the membranes of presynaptic nerve cells. It serves as part of a negative feedback loop in signal transduction. It is only sensitive to the neurotransmitters or hormones released by the neuron on which the autoreceptor sits. For example, presynaptic NMDA receptors are sensitive to glutamate released from presynaptic vesicles. Autoreceptors usually do not generate changes in membrane potential. Instead, they often function to control internal cell processes, including synthesis and release of the neurotransmitter. Because of the important role of D2 autoreceptors in regulating dopamine synthesis, they aimed to examine whether subjects with the A1 allele have altered presynaptic dopamine function in the brain. There is evidence of enhanced sensitivity of D2 autoreceptors to alterations by lead (Zuch et al. The histamine H3 receptor is predominantly expressed in the brain, and inverse agonists of the H3 receptor increase the synthesis and release of histamine through inhibition of presynaptic autoreceptors.
Its located on presynaptic nerve cell terminals and sensitive only to those neurotransmitters or hormones that are released by the neuron in whose membrane the autoreceptor sits.