Hemophilia is an X-linked condition caused by a recessive gene.
Example: Hemophilia A. Hemophilia A is an X-linked recessive disease caused by a lack of a coagulant, or blood clotting agent, called factor VIII (factor 8). This is caused by a mutation in a gene on the X chromosome called F8.If a father is affected, his daughters will be carriers of hemophilia A and his sons will be unaffected.or an X-linked dominant condition, only one copy of a gene on the X chromosome whether in a female with two X chromosomes or males with on X chromosome must have a change or mutation for an individual to be affected with the condition. X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome. Females have two X chromosomes; males have one X and one Y. Genes on the X chromosome can be recessive or dominant.Their expression in females and males is not the same.Genes on the Y chromosome do not exactly pair up with the genes on the X chromosome. X-linked recessive genes are expressed in females only if there are two copies of the gene (one on each X chromosome).heir expression in females and males is not the same. Genes on the Y chromosome do not exactly pair up with the genes on the X chromosome. X-linked recessive genes are expressed in females only if there are two copies of the gene (one on each X chromosome). Back to Top Causes. Hemophilia B is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. Females have two copies of the X chromosome.If the factor IX gene on one chromosome does not work, the gene on the other chromosome can do the job of making enough factor IX.ack to Top Causes. Hemophilia B is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. Females have two copies of the X chromosome. Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. The genes associated with these conditions are located on the X chromosome, which is one of the two sex chromosomes.n females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, it is very rare for females to have hemophilia. The major types of this condition are hemophilia A (also known as classic hemophilia or factor VIII deficiency) and hemophilia B (also known as Christmas disease or factor IX deficiency). Although the two types have very similar signs and symptoms, they are caused by mutations in different genes.n females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, it is very rare for females to have hemophilia. Examples of X-linked recessive conditions include red-green color blindness and hemophilia A: Red-green color blindness. Red-green color blindness simply means that a person cannot distinguish shades of red and green (usually blue-green). Their visual acuity (ability to see) is normal.heir expression in females and males is not the same. Genes on the Y chromosome do not exactly pair up with the genes on the X chromosome. X-linked recessive genes are expressed in females only if there are two copies of the gene (one on each X chromosome). Another form of the disorder, known as acquired hemophilia, is not caused by inherited gene mutations. This rare condition is characterized by abnormal bleeding into the skin, muscles, or other soft tissues, usually beginning in adulthood.n females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, it is very rare for females to have hemophilia. 1 Hemophilia A, a blood clotting disorder caused by a mutation of the Factor VIII gene and leading to a deficiency of Factor VIII. 2  It was once thought to be the royal disease found in the descendants of Queen Victoria. 3  This is now known to have been Hemophilia B (see below).he most common X-linked recessive disorders are: 1  Red-green color blindness, a very common trait in humans and frequently used to explain X-linked disorders. 2  Between seven and ten percent of men and 0.49% to 1% of women are affected. X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome. Females have two X chromosomes, while males have one X and one Y chromosome.he most common X-linked recessive disorders are: 1  Red-green color blindness, a very common trait in humans and frequently used to explain X-linked disorders. 2  Between seven and ten percent of men and 0.49% to 1% of women are affected. X-linked Recessive: Red-Green Color Blindness, Hemophilia A. Genes are inherited from our biological parents in specific ways. One of the basic patterns of inheritance of our genes is called X-linked recessive inheritance.heir expression in females and males is not the same. Genes on the Y chromosome do not exactly pair up with the genes on the X chromosome. X-linked recessive genes are expressed in females only if there are two copies of the gene (one on each X chromosome).
Yes