[Sequencing and their use in the study of fundamental HIV virus].
The only massive sequencing genomes, also known as Ultra Deep Sequencing (UDS), has allowed great advances in the field of biomedical sciences. In the field of virology, is an excellent opportunity to study the genetic variability of the virus. Therefore, in the scenario of a virus with high replication capacity and high error rate of the enzyme that is responsible for this process, such as the Human Immunodeficiency Virus (HIV), the UDS provides a tool particularly useful to characterize more fully the details related to its variability. In this regard, one of the greatest advances has been the characterization of what has been termed "virus founders" in HIV infection, the disclosure is of particular importance in the development of vaccines against HIV. This technology also allows the estimation of HIV related virological aspects as important as population dynamics, viral evolution, and the study and characterization of superinfections and superinfections.