What is a haplotype map? A brief look at the data. How haplotypes are used for disease-gene mapping. An explanation of why a haplotype map is useful. A resource for other studies, not for direct clinical use. Importance of ethical issues

1:40 p.m. - 2:10 p.m.

Developing a haplotype map:
An overview of the population genetic issues:

Aravinda Chakravarti

Genetic definition of a population. Demographic and historical factors affecting the behavior of genes and their variants in populations (genetic isolate, founder effects, immigration, emigration and admixture). Fluidity of boundaries and changes over time. Genetic versus social definitions of populations. Group definitions, risks of group stigmatization and related ethical issues.

Ethical and social issues relating to the inclusion of identified populations in a haplotype map project:

Troy Duster
[25 min. talk and 15 min. discussion]

Consequences of inclusion vs. exclusion of certain groups. Eliminating vs. retaining ethnic identifiers in the reference set. Risks of this project conveying more meaning to race/ethnicity than it deserves.

7:00 p.m. - 9:30 p.m.

Panel and discussion on the ethical and social issues relating to the inclusion of identified populations in a haplotype map project and the meaning of consentPanel: Ellen Wright Clayton (moderator), Mildred Cho, Phyllis Epps, Marla Jasperse, Thomas Murray, Pilar Ossorio, Charles Rotimi

Thursday, July 19

8:00 a.m. - 8:30 a.m.

Breakfast

Discussion, with moderators shown

8:30 a.m. - 12:00 noon

Structuring a Haplotype Map Project:

David Bentley, Charmaine Royal, and David Altshuler

A) Methods for defining haplotypes and the kinds of samples needed: Leonid Kruglyak
B) What types of markers and what density? Deborah Nickerson
C) Involving communities in the research process: Morris Foster

12:00 p.m.- 12:15 p.m.

Break to get working lunch

12:15 p.m. - 1:30 p.m.

Organization of a haplotype map project:

Francis S. Collins

Timing of the process. Need for piloting steps. How interested groups can work together.