Introduction
============

Connectomics, which is conceptualized as the mapping of the organization and the complete interactions of all neural elements in the brain, is currently a popular framework for studying brain structure and function.[@b1-ndt-11-2801]--[@b3-ndt-11-2801] Based on advances in in vivo neuroimaging techniques (eg, functional magnetic resonance imaging \[fMRI\], structural magnetic resonance imaging \[sMRI\], and diffusion magnetic resonance imaging \[dMRI\]), the network of the brain, or the connectome, has been widely mapped as a collection of nodes (neurons or brain regions) and edges (neural connections or pathways). Modern graph theory and complex network can be applied to detect and quantify the topological features of large-scale connectomes.[@b4-ndt-11-2801]--[@b7-ndt-11-2801] A number of nontrivial features of brain connectomes have been revealed, such as its efficient small-world architecture, the presence of densely connected communities or modules of brain regions, and the existence of highly connected and highly central network hubs.[@b8-ndt-11-2801] A wealth of evidence indicates that these organizational principles are not only correlated with behavioral function and cognitive ability[@b8-ndt-11-2801]--[@b12-ndt-11-2801] but are also disturbed in brain disorders.[@b13-ndt-11-2801]--[@b15-ndt-11-2801]

Impairment of higher cognitive function is a key feature of psychiatric disorders, which severely compromise the well-being of affected individuals in modern society and which negatively impacts general health. Psychiatric disorders can have an early onset (eg, autism in childhood and schizophrenia in young adulthood) or a relapsing--remitting course (as in depression and anxiety disorders and obsessive--compulsive disorder), and these disorders often involve disabling symptoms.[@b16-ndt-11-2801] According to statistics from the World Health Organization ([www.who.int](http://www.who.int)), these disorders have a relatively high prevalence and exert a heavy burden on both individuals and society. Although the psychological mechanisms of psychiatric diseases have attracted significant attention, the objective delineation of the pathophysiological mechanisms underlying these diseases remains a great and perennial challenge. Moreover, identifying biomarkers that would be valuable for informing clinical diagnosis, monitoring disease progression, and evaluating treatment effects is especially difficult. Recently, a new concept termed pathoconnectomics, reflecting an extension of connectomics to the psychiatric field, has been proposed as a framework for the study of brain dysfunction in psychiatric disorders in which the corresponding abnormal brain networks are mapped.[@b17-ndt-11-2801] Pathoconnectomics assumes that major psychiatric disorders involve abnormalities of brain networks and that understanding the aberrant organization of brain networks is critical for understanding these brain disorders. In this sense, pathoconnectomics requires evidence concerning the disruption of brain networks to serve as a validated scientific and clinical framework that reveals the phenotypes characterizing psychiatric disorders.

In this review, we summarize recent progress in the connectomic analysis of psychiatric disorders using both structural and functional neuroimaging data. First, we introduce several basic concepts of brain connectomics and the relevant graph theory approaches. Then, we summarize the recent findings of large-scale brain connectome studies in three major disorders, ie, schizophrenia, attention deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). Finally, we briefly discuss the limitations and future considerations of pathoconnectomic analysis in psychiatric populations.

Human connectomics and graph theory
===================================

An important goal of human connectomics is to characterize the structural and functional brain connections using advanced neuroimaging technologies, referred to as the concept of "connectome".[@b2-ndt-11-2801],[@b3-ndt-11-2801],[@b18-ndt-11-2801] Over the last decade, advances in in vivo neuroimaging techniques and computational tools have offered great opportunities to map the structural and functional connections in the human brain at the macro scale for humans. In the present article, we constricted our review to studies using resting-state fMRI, dMRI, or sMRI.

A large-scale brain network, or connectome, is represented by a graph model consisting of nodes, which usually represent imaging voxels or regions of interest, and edges, which represent the functional connectivity or structural connectivity linking nodes, based on different strategies (ie, a broad range of strategies for brain parcellations and interregional connectivity measurements).[@b1-ndt-11-2801],[@b4-ndt-11-2801],[@b19-ndt-11-2801] Briefly, functional connectivity is defined as statistical temporal dependences as demonstrated by synchronous blood oxygen-level dependent neural activity over the distributed brain areas.[@b2-ndt-11-2801] Structural connectivity is defined as dMRI-traced white matter fiber tracts between the regions of interest or covariance in morphologic measures (eg, cortical thickness or gray matter volume) scaled by sMRI across individuals.[@b20-ndt-11-2801],[@b21-ndt-11-2801]

Modern graph theory and complex network are then applied to detect and quantify the features of the resultant networks that are relevant to the topological organization of the brain. To date, many important topological properties of complex networks have been characterized, such as small-worldness (ie, the optimal balance of both high local clustering and high global integrity), modular structure (ie, sets of nodes that are highly interconnected but have relatively fewer connections to the others in different modules), and the presence of hubs (ie, topologically centralized nodes) and rich-club structures (ie, a set of densely interconnected hubs).[@b5-ndt-11-2801],[@b7-ndt-11-2801],[@b19-ndt-11-2801],[@b20-ndt-11-2801]

Next, we briefly introduce these crucial network measurements from the perspectives of information segregation and integration in the brain networks. Specifically, topological segregation of the brain refers to the information processing among local communities or clusters of nodes that are highly interconnected.[@b19-ndt-11-2801],[@b22-ndt-11-2801] The clustering coefficient and modularity are two frequently used metrics that quantify the localization/specialized processing of brain networks. The clustering coefficient of a node is defined as the number of existing connections among the node's immediate neighbors divided by all of their possible connections;[@b21-ndt-11-2801] this parameter reflects the extent of cliquishness and is related to local efficiency and fault-tolerance of the network. The modularity is determined by a single statistic of reflecting the ratio of intramodular to intermodular edges; the mathematically optimal modular decomposition of a network is obtained by maximizing this ratio.[@b19-ndt-11-2801] In contrast, integration refers to the efficiency of global information communication or the ability of integrating distributed information in the network.[@b19-ndt-11-2801] The efficiency of global information transfer is usually measured by the characteristic path length of a network, which is the averaged shortest path length of all nodes. The characteristic path length of a network is inversely proportional to the efficiency of parallel information transfer. Alternatively, the ability to integrate distributed information can be scaled based on the existence of network hubs which exhibit high centralities (eg, degree/the number of connections for a node). Importantly, these high-degree or high-central hubs have a strong tendency to be densely interconnected and to form a rich-club structure in the brain organization ([Figure 1A](#f1-ndt-11-2801){ref-type="fig"}), generating a central backbone for global brain communication.[@b22-ndt-11-2801],[@b23-ndt-11-2801] Finally, the attractive architecture of small-world organization, which represents the combination of high clustering and short characteristic path length, could support both high segregated/specialized and highly distributed/integrated information processing.[@b7-ndt-11-2801],[@b24-ndt-11-2801]

Connectomics in psychiatric disorders
=====================================

In this section, we summarize the recently reported abnormalities of both the structural and functional whole-brain connectomes in schizophrenia, ADHD, and ASD. These three disorders constitute a large proportion of the current connectomics literature and are all hypothesized to be developmental disorders.[@b1-ndt-11-2801],[@b14-ndt-11-2801] In addition to the specific alterations in the connectomes of each disorder, the shared and distinct disturbances between these disorders are discussed. Studies focused on the connectome of other psychiatric disorders, such as major depression, can be found in other reviews.[@b13-ndt-11-2801],[@b25-ndt-11-2801]

Abnormalities of the connectomes in schizophrenia
-------------------------------------------------

Historical hypotheses that schizophrenia is a dysconnectivity disorder have recently been validated by abundant connectomic studies.[@b26-ndt-11-2801] First, reduced whole-brain structural and functional connectivity has been broadly reported.[@b27-ndt-11-2801]--[@b29-ndt-11-2801] Regarding the topological abnormalities observed in schizophrenia, as summarized in recent reviews,[@b30-ndt-11-2801]--[@b32-ndt-11-2801] the structural connectome in patients tends to follow an overall pattern of network organization that is more segregated, characterized by increased clustering coefficient and modularity, and less integrated, characterized by reduced global efficiency. Additionally, a recent study using diffusion spectral imaging identified a distributed set of brain nodes associated with the disease processes as the affected core of schizophrenia, and the altered function of these nodes may drive the global efficiency loss observed in patients.[@b33-ndt-11-2801] In contrast, the functional topological organization of the brain in schizophrenia showed a randomized tendency, ie, increased global integration but decreased local segregation. Network analysis revealed that the functional networks in schizophrenia patients exhibited less clustered and equally or more distributed communication organization, as demonstrated by reduced clustering and modularity and increased global efficiency compared with healthy controls.[@b27-ndt-11-2801],[@b34-ndt-11-2801],[@b35-ndt-11-2801] Moreover, it has been reported that the changes in the topological properties of the functional networks in schizophrenia patients were associated with a proportional increase in anatomical length (Euclidean distance).[@b36-ndt-11-2801],[@b37-ndt-11-2801] Notably, inconsistent results were reported concerning functional analysis in schizophrenia,[@b38-ndt-11-2801],[@b39-ndt-11-2801] and these discrepancies might be influenced by many factors, such as the use of different analysis methods or heterogeneous patient cohorts; thus, this issue must be clarified further. Analysis of drug effects[@b40-ndt-11-2801] revealed that sulpiride, a drug commonly used for schizophrenia, reduced both global and local efficiency of the functional brain networks of healthy volunteers. This finding might provide insight into pharmacological treatment from the connectomics perspective. Recently, an fMRI study explored the dynamic topological properties of time-varying functional connectivity in schizophrenia and found decreased variance in the dynamic topological parameters, including the strength, clustering coefficient, and global efficiency, indicating that the temporal connectivity patterns could also be altered in schizophrenia.[@b41-ndt-11-2801] In addition to these inconsistent findings in separate studies of structural and functional networks, both increased[@b28-ndt-11-2801] and decreased[@b42-ndt-11-2801] functional--structural coupling have been reported in schizophrenia patients. These results indicate the urgent need for further investigation to explain these observed divergences in structure and function.[@b43-ndt-11-2801]

The dysconnectivity observed in schizophrenia also appears to manifest from an abnormal hub organization. A less hub-dominated configuration has been observed in functional and structural schizophrenia connectomes.[@b27-ndt-11-2801],[@b43-ndt-11-2801],[@b44-ndt-11-2801] Specifically, reports have demonstrated that schizophrenia patients exhibit reduced regional centrality in hubs including the frontal association, parietal, limbic, and paralimbic brain areas based on structural studies, and including the frontal, temporal, parietal, limbic, and occipital areas based on functional studies. Recently, van den Heuvel et al found that the structural rich-club organization, a highly interconnected backbone comprising the hub regions, was also disturbed in schizophrenia patients ([Figure 1B](#f1-ndt-11-2801){ref-type="fig"}).[@b28-ndt-11-2801] Their findings indicate that a selective disruption of brain connectivity among central hub regions of the schizophrenic brain may lead to reduced communication capacity and altered functional brain dynamics. Notably, a recent study indicated that the global signal in fMRI data contains critical information relevant to schizophrenia, emphasizing that preprocessing steps should be more carefully performed in further analysis.[@b45-ndt-11-2801]

Abnormalities of the connectomes in ADHD
----------------------------------------

Both structural and functional connectomics studies of ADHD have reported altered connectivity mainly located in the dorsal attention, sensorimotor, default mode network (DMN), and subcortical regions ([Figure 2A and B](#f2-ndt-11-2801){ref-type="fig"}).[@b46-ndt-11-2801]--[@b51-ndt-11-2801] Specifically, different changes in connectivity pattern accounted for the two primary symptoms of ADHD: decreased connectivity in prefrontal-dominant circuitry and increased connectivity in orbitofrontal-striatal circuitry were significantly correlated with behavioral scores of inattention and hyperactivity/impulsivity symptoms, respectively, in ADHD patients ([Figure 2A and B](#f2-ndt-11-2801){ref-type="fig"}).[@b48-ndt-11-2801],[@b52-ndt-11-2801] After stratifying the patients into two subgroups (inattentive or combined AHDH) according to their behavioral symptoms, the analysis results provide compelling evidence for the involvement of distinct mechanisms in different behavioral abnormalities.[@b47-ndt-11-2801] The regional degree patterns of the inattentive and combined subgroups displayed similar abnormalities in the sensorimotor regions compared with normal controls. However, the inattention ADHD subgroup exhibited unique atypical patterns in the dorsal lateral prefrontal cortex and the cerebellum, whereas the combined ADHD group exhibited unique patterns in the midline components of the DMN. Moreover, Sripada et al[@b53-ndt-11-2801] found that methylphenidate, a drug commonly used for ADHD, reduced the functional coupling within the visual and somatomotor networks and enhanced the decoupling between the DMN and several task positive networks in healthy human volunteers; these results indicate that methylphenidate may modulate brain connectivity to enhance human attentional function.

Global topological analyses have revealed reductions in both global integration and local clustering in both structural and functional connectomes, and these findings indicate a regular shift in organizational properties in ADHD patients.[@b52-ndt-11-2801],[@b54-ndt-11-2801]--[@b56-ndt-11-2801] Furthermore, an electroencephalogram study reported that compared with controls, ADHD patients exhibited lower global brain network, which was improved (increased global network efficiency) after effective neurofeedback therapies.[@b55-ndt-11-2801] Notably, no functional global topological alterations were observed in ADHD adults, although regional disturbances remained.[@b57-ndt-11-2801] Disrupted hubs have also been found in both functional and structural networks,[@b44-ndt-11-2801],[@b48-ndt-11-2801],[@b49-ndt-11-2801] supporting the conclusion that global integration is disturbed in ADHD.

One popular hypothesis is that wiring abnormalities in the brains of patients with developmental disorders may arise from a dysplastic developmental lesion.[@b14-ndt-11-2801],[@b58-ndt-11-2801] The significantly decreased functional connectivity pattern in the DMN of ADHD patients was found to greatly overlap with the patterns observed developmental dynamics in healthy populations; this result indicates that ADHD is associated with developmental delay.[@b46-ndt-11-2801] Recently, a study tested the hypothesis with subjects aged from 7 to 21 years old to compare the development curves of ADHD and healthy controls.[@b59-ndt-11-2801] The authors found that ADHD children exhibited a lag in the maturation of functional connections both within and between subnetworks. Nevertheless, further studies are needed to obtain structural evidence and to perform comprehensive connectome organization analysis to corroborate this maturation lag theory.

Abnormalities of the connectomes in ASD
---------------------------------------

The whole-brain network functional analysis findings in ASD relatively consistently show hypoconnectivity in the so-called "social network" encompassing the default mode, attention and executive networks ([Figure 3A](#f3-ndt-11-2801){ref-type="fig"}) and hyperconnectivity in limbic regions ([Figure 3B](#f3-ndt-11-2801){ref-type="fig"}).[@b60-ndt-11-2801]--[@b65-ndt-11-2801] Interestingly, altered contributions of nonspecific skin conductance responses, an objective index of sympathetic neural activity, to functional connectivity have been reported in these disturbed regions in ASD patients.[@b64-ndt-11-2801] These findings indicate that abnormal socioemotional behavior in ASD individuals may be correlated with autonomic processing alterations.[@b64-ndt-11-2801] Some models describe the ASD brain connectome as dominated by reduced long-range connections and excessive short-range fibers. In support of these theoretical models, network analysis based on electroencephalogram and magnetoencephalography has revealed a lack of long-range connections and an increase in short-range connections in ADHD patients compared with healthy controls.[@b66-ndt-11-2801],[@b67-ndt-11-2801] Structural analysis also showed disrupted long-range "socioemotional" circuits.[@b68-ndt-11-2801],[@b69-ndt-11-2801] The prefrontal cortex, the key region of the social network, is a commonly targeted region for transcranial magnetic stimulation as a treatment for ASD,[@b70-ndt-11-2801],[@b71-ndt-11-2801] indicating the instructional potential of connectomic analysis.

The topological properties of functional networks were found to exhibit a randomized tendency of decreased segregation, as reflected by decreased modularity and local clustering in ASD patients,[@b62-ndt-11-2801],[@b72-ndt-11-2801] nonclinical populations with autistic traits,[@b73-ndt-11-2801] and carriers of the autism risk gene.[@b74-ndt-11-2801] However, both decreased and increased[@b62-ndt-11-2801] local clustering coefficients were found in structural studies of ASD patients, which were relatively inconsistent. A recent diffusion tensor imaging study conducted on 24-month-old babies showed a significantly decreased local and global efficiency among the temporal, parietal, and occipital lobes in high-risk infants diagnosed with ASD, compared to both low- and high-risk infants not diagnosed with ASD.[@b75-ndt-11-2801] Reduced global efficiency was found only in Broca's area in these ASD infants.[@b75-ndt-11-2801] In addition, these alterations significantly correlated with symptom severity among the high-risk infants (including ASD and non-ASD infants).[@b75-ndt-11-2801] These findings suggest that infants with ASD exhibit disturbances in the organization of both the local and global aspects of the network structure in the brain regions that are primarily involved in the processing of auditory, visual, language, and nonlinguistic social stimuli. Additionally, both functional and structural hubs are disturbed in ASD, indicating dysfunction in global integration,[@b44-ndt-11-2801],[@b49-ndt-11-2801] and suggesting a disruption in global integration capacity. Taken together, these findings in ASD are fairly inconsistent, and further analyses are urgently needed to reveal the mechanism underlying this dysfunction.

Shared and distinct alterations between different disorders
-----------------------------------------------------------

As summarized earlier, specific connectomic disturbances in each disorder have been reported: schizophrenia patients show abnormalities primarily in the frontal-temporal regions and a randomized organization; ADHD patients show significant alterations in the prefrontal and orbitofrontal-striatal circuitries with an ordered tendency; and ASD patients exhibited alterations located in the social network and sub-cortical regions.

Although significant and specific alterations in the connectomes of individuals with psychiatric disorders have been detected, similar clinical symptoms are shared between psychiatric disorders. Thus, the characterization of shared and unique abnormalities in psychiatric connectomes is important for understanding the neural mechanisms underlying comorbidities. For example, individuals with ASD often exhibit symptoms of ADHD, ie, inattention and hyperactivity/impulsivity, and the *Diagnostic and Statistical Manual of Mental Disorders*, 5th Edition, diagnostic criteria permit the coincident diagnosis of ADHD and ASD. Connectomic analysis[@b49-ndt-11-2801] revealed that both ADHD and ASD subjects exhibit nodal centrality abnormalities in the precuneus but that other disturbances were disorder-specific: ADHD was associated with increased degree in the right striatum/pallidum, and ASD was associated with increased degree in the bilateral temporo-limbic areas. Disorder-specific alterations in rich-club organization were also reported; specifically, ASD patients exhibited hyperconnectivity within the rich-club structure and comparable connectivity outside the rich-club structure, whereas ADHD patients showed hypoconnectivity within the rich-club structure and hyperconnectivity outside the rich-club structure.[@b76-ndt-11-2801] Additionally, schizophrenia shares some similar symptoms with bipolar disorder. Comparisons of whole-brain functional connectivity between schizophrenia, bipolar disorder, and healthy control subjects revealed both common and distinct disruptions between these two disorders, particularly a lowest-to-highest schizophrenia/bipolar disorder/healthy subject spectrum of total connectivity.[@b77-ndt-11-2801],[@b78-ndt-11-2801] Interestingly, recent studies that integrated the data obtained for various neuropsychiatric disorders found that most of these disorders primarily attack brain hubs in both the structural and functional connectomes, although distinct subsets of cortical hubs were lesioned in each disorder.[@b44-ndt-11-2801],[@b79-ndt-11-2801] Moreover, schizophrenia, bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety were commonly associated with gray matter loss in three regions: the dorsal anterior cingulate cortex and the bilateral insula, suggesting that a common neurobiological substrate may exist across these mental illnesses.[@b79-ndt-11-2801]

Recently, a developmental perspective has been increasingly accepted in the field of psychiatric disorders.[@b14-ndt-11-2801] Models of developmental miswiring have been proposed, such as delayed wiring for ADHD,[@b46-ndt-11-2801],[@b80-ndt-11-2801] and immature or ectopic wiring for ASD.[@b81-ndt-11-2801] Compared with the two disorders, schizophrenia has been examined in relatively few age-related studies.[@b58-ndt-11-2801] However, there is also a hypothesis that aberrant maturation of late developing systems, which primarily include connectivity hubs in the association cortex that integrate information from diverse network elements, causes dysfunction of critical circuits in schizophrenia, thereby eliciting clinical symptoms in late adolescence and early adulthood.[@b32-ndt-11-2801] Further studies are needed to test these hypotheses.

Conclusion and future perspectives
==================================

This review summarizes the recent connectomics studies related to psychiatric disorders. The discussed findings imply that characteristic abnormalities in the connectomes of psychiatric patients may provide novel insight into the pathophysiological mechanisms underlying psychiatric disorders, reveal the mechanisms underlying various treatments,[@b40-ndt-11-2801],[@b55-ndt-11-2801] and identify potential therapeutic targets for these disorders[@b25-ndt-11-2801],[@b82-ndt-11-2801] from a connectomics perspective. However, several important challenges for future research remain.

First, the present results across modalities were discrepant in many aspects, and it is difficult to determine whether these discrepancies reflect additional biological information or limitations of the analysis or imaging methods. Moreover, it is believed that the complex structural--functional relationship is disturbed in psychiatric disorders, although this hypothesis requires further assessment.[@b83-ndt-11-2801] Future studies should include measurements and integration of the structural and functional connectomes based on multiple MRI modalities in the same participants; larger sample sizes and repeated measurements on each subject; and correlation analyses between the observed changes and specific, refined cognitive measurements or disorder symptoms. Second, the disturbed regions revealed by connectomic analysis of these disorders (such as the striatum for ADHD and the fronto-temporal cortex for schizophrenia) are also detected via several other analysis methods (such as functional activation and structural geography studies). The mechanisms underlying the manifestations of a shared aberration, such as an identical cause or causal relationship, are very interesting. Some physiological parameters that are closely associated with psychiatric disorders have been correlated with both connectomic properties and the structural index in both healthy controls and psychiatric patients;[@b7-ndt-11-2801],[@b84-ndt-11-2801]--[@b86-ndt-11-2801] this finding suggests a physiological and neurochemical basis underlying the dysfunctions observed in these patients. Future studies are necessary to clarify these issues. Third, different psychiatric disorders often share aberrant behavioral symptoms, and the exploration of the mechanisms underlying these symptoms has attracted more and more attention. However, accumulated evidence has indicated that different data acquisition sequences, preprocessing steps, and analysis methods, such as parcellation and correlation calculations, produce discrepant results,[@b87-ndt-11-2801]--[@b89-ndt-11-2801] which renders the integration of results across different studies difficult. Further research across different comorbid disorders should be conducted on data for different disorders obtained using identical data processing sequences and analysis methods. Moreover, studies exploring the effects of many influences, such as environmental or genetic factors, age, disease progression, and clinical treatment, on pathoconnectomics are urgently needed. We hope that the accumulation of validated evidence from connectomics will reveal biological markers that indicate the specific phenotypes of psychiatric disorders.

This work was supported by the National Key Basic Research Program of China (973 Project, No 2014CB846102), a National Science Fund for Distinguished Young Scholars Grant (No 81225012), the Natural Science Foundation of China (No 31221003), and the Beijing Natural Science Foundation (No Z151100003915082, No 2012D009012000003).

**Disclosure**

The authors have no conflicts of interest to disclose.

![Disturbed rich-club organization in schizophrenia.\
**Notes:** (**A**) The rich-club members in both the healthy and psychiatric populations included the bilateral precuneus, the superior frontal cortex, the superior parietal cortex, and the insula. (**B**) The edges in individual brain networks (both controls and patients) were divided into three distinct classes: rich-club connections linking rich-club members (red), feeder connections linking rich-club members to non-rich-club members (orange), and local connections connecting non-rich-club members (yellow). The figure on the right shows a significant reduction in the density of rich-club connections, but not feeder or local connections, in psychiatric patients. Adapted from: van den Heuvel MP, Sporns O, Collin G, et al. Abnormal rich-club organization and functional brain dynamics in schizophrenia. *JAMA Psychiatry*. 2013;70(8):783--792. Copyright © 2013 American Medical Association. All rights reserved.[@b28-ndt-11-2801]\
**Abbreviation:** ROI, region of interest.](ndt-11-2801Fig1){#f1-ndt-11-2801}

![Disturbed connectivity in ADHD.\
**Notes:** (**A**) Decreased or increased functional connectivity density (FCD) in ADHD patients compared with the healthy controls. (**B**) Decreased or increased white matter connections in ADHD participants compared with healthy controls and their relationships with the clinical characteristics of the patients. Blue curve: the significantly decreased network-based statistic (NBS) component; red curve: the significantly increased NBS component. (**A**) Adapted from *Biological Psychiatry*, 71(5), Tomasi D, Volkow ND, Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder, 443--450, Copyright © 2012, with permission from Elsevier.[@b48-ndt-11-2801] (**B**) Adapted with permission of Society for Neuroscience, from Probabilistic diffusion tractography and graph theory analysis reveal abnormal white matter structural connectivity networks in drug-naive boys with attention deficit/hyperactivity disorder, Cao Q, Shu N, An L, et al, 33(26), Copyright © 2013; permission conveyed through Copyright Clearance Center, Inc.[@b52-ndt-11-2801]\
**Abbreviations:** ADHD, attention deficit/hyperactivity disorder; SFGdor, superior frontal gyrus, dorsolateral; SFGmed, superior frontal gyrus, medial; ORBmid, middle frontal gyrus, opercular part; ORBsup, superior frontal gyrus, orbital part; ORBsupmed, superior frontal gyrus, medial orbital; ORBinf, inferior frontal gyrus, orbital part; MFG, middle frontal gyrus; IFGoperc, inferior frontal gyrus, opercular part; INS, insula; THA, thalamus; CAU, caudate nucleus; PUT, lenticular nucleus, putamen; HES, heschl gyrus; PreCG, precentral gyrus; PoCG, postcentral gyrus; PCL, paracentral lobule; SPG, superior parietal gyrus; ANG, angular gyrus; TPOsup, temporal pole superior temporal gyrus; MTG, middle temporal gyrus; ITG, inferior temporal gyrus; STG, superior temporal gyrus; IOG, inferior occipital gyrus; SOG, superior occipital gyrus; LING, lingual gyrus; R, right; L, left.](ndt-11-2801Fig2){#f2-ndt-11-2801}

![The brain regions displaying disrupted functional connectivity in autism.\
**Notes:** (**A**) Areas of the "social brain" that have been found to exhibit decreased functional connectivity in autism. (**B**) Voxels displaying altered functional connectivity in autism. The color bar represents the degree of connectivity according to the number of significantly affected edges relating to a given voxel. Voxels that displayed weaker functional connectivity in the autistic population than in the controls are shown in blue, and the voxels that displayed stronger functional connectivity in the autistic population are shown in red. Figures are adapted with permission from *Brain* (<http://brain.oxfordjournals.org>): Gotts SJ, Simmons WK, Milbury LA, Wallace GL, Cox RW, Martin A. Fractionation of social brain circuits in autism spectrum disorders. *Brain*. 2012;135(Pt 9):2711--2725[@b61-ndt-11-2801] and Cheng W, Rolls ET, Gu H, Zhang J, Feng J. Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self. *Brain*. 2015;138(Pt 5):1382--1393.[@b63-ndt-11-2801]\
**Abbreviations:** L, left; R, right; MA, measure of association; MTG, medial temporal gyrus; STG, superior temporal gyrus; ITC, inferior temporal gyrus; MFG, middle frontal gyrus; ORBsupmed, ventromedial prefrontal cortex; PCUN, precuneus; CUN, cuneus; PCL, paracentral lobule; PoCG, postcentral gyri; PreCG, precentral gyri; THA, thalamus; SFGdors, superior frontal gyrus, dorsal part.](ndt-11-2801Fig3){#f3-ndt-11-2801}

[^1]: These authors contributed equally to this work
