Hydroxyacylglutathione hydrolase

In enzymology, a Hydroxyacylglutathione hydrolase () is an enzyme that catalyzes the chemical reaction

(R)-S-lactoylglutathione + water  glutathione + a 2-hydroxy carboxylate

Hence, this enzyme has two substrates, (R)-S-lactoylglutathione and water, and two products, glutathione and a 2-hydroxy carboxylate. With the common substrate methylglyoxal, the product is D-lactate.

This enzyme belongs to the family of hydrolases, specifically the class of thioester lyases.  This enzyme is commonly known as glyoxalase II.  This enzyme participates in pyruvate metabolism.

References

Category:EC 3.1.2
Category:Enzymes of known structure