Types of Commonly Misused or Abused Drugs

Learn about the three most commonly misused or abused types of legal drugs: opioid analgesics, psychiatric, and over-the-counter.

Opioid Pain Relievers

Opioid pain relievers reduce the pain associated with many conditions, including cancer, arthritis and other degenerative conditions. They are also used to alleviate short-term pain related to injuries, surgery, or dental work.

There are different kinds of pain medications, including nonsteroidal anti-inflammatory drugs and opioid analgesics, each type with various advantages and risks. Pain treatment, whether it is acute or chronic, should be individualized for the patient and assessed at frequent intervals, and non-medication therapies should also be considered.

The use of opioid pain relievers exposes users to risks of overdose, dependence, and addiction. Careful consideration should be taken when determining whether an opioid pain reliever is appropriate. Those who abuse them sometimes alter the route of administration (e.g., snorting or injecting) to intensify the effect. The use of opioids, alone or with alcohol or other prescription or illicit drugs, can cause sleepiness, confusion, and slow or stopped breathing leading to overdose and even death.

Opioid misuse and abuse continues to be a major public health problem in the United States. From 1999 to 2013 the rate of death from opioid pain reliever overdose nearly quadrupled. Deaths from heroin have also increased sharply since 2010, with a 39% increase between 2012 and 2013. Examples of opioid pain relievers include drugs that contain the active ingredient codeine, hydrocodone, and oxycodone, to name a few.

Psychiatric Drugs

Psychiatric drugs are prescribed by health care practitioners to treat mental illnesses such as depression, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, and anxiety disorders. Commonly prescribed medications that have been abused include sedative medications in a class of drug called benzodiazepines, such as alprazolam (Xanax®), clonazepam (Klonopin®), and diazepam (Valium®), and the antipsychotic medication, quetiapine (Seroquel®). These medications alone or in combination with other drugs can produce sedation and euphoria (“high”). Hypnotic medications that help with insomnia can also be abused. An example of such a medication is zolpidem (Ambien®).

Another class of medications used to treat attention deficit disorders includes stimulants. Stimulants may temporarily increase alertness and energy and have a calming and “focusing” effect on individuals with attention deficit hyperactivity disorder. Stimulants include amphetamines such as Adderall® and methylphenidate (Ritalin® and Concerta®). In 2010, according to the National Institute on Drug Abuse, about 1.1 million people abused stimulants, which are used to treat attention deficit hyperactivity disorder and narcolepsy. Side effects of stimulant overuse can include psychosis, seizures, and cardiovascular complications.

Over-the-Counter (OTC) Drugs

OTC drugs do not require a prescription. However, many OTC drugs contain ingredients that can be abused. Learn more about OTC drugs and ways SAMHSA is addressing this issue at the Alcohol, Tobacco, and Other Drugs topic.