Control of food intake through regulation of cAMP.
The 3', 5'-cyclic adenosine monophosphate (cAMP) is a classic second messenger that is intimately involved in the regulation of food intake at the hypothalamus. cAMP can mediate the orexigenic and anorectic effects of various peripheral hormones or neuropeptides in a region-specific and neuron-specific manner. The importance of cAMP is particularly highlighted in a series of findings about cAMP transducing the anorectic signals of leptin and alpha-msh. This chapter provides an overview of several studies on how regulation of food intake takes place with cAMP as the second messenger in the hypothalamus.