If you don't use it you'll likely lose it.
This article is a commentary on the recently published manuscript by Drey et al. (2014). The age-related loss of motor units (MU) is an immutable process and understanding the possible role of physical activity in maintaining functional MUs is an important topic. Dysfunctional remodelling of a MU is associated with denervation of the muscle and ultimate death of the spinal motoneurone. Conversely, in cross-sectional studies, high levels of physical activity in humans report a maintenance in the number of functional MUs in older master runners. However, it seems that only those MUs directly associated with the elevated long-term physical activity appear to benefit from any exercise-induced neuroprotective effect.