The role of Doppler and placental screening.
Placental-associated diseases account for most cases of adverse perinatal outcome in developing countries. Uterine Doppler evaluation predicts most instances of early-onset preeclampsia and intrauterine growth restriction, but there is no evidence in favour of any prophylactic strategy in cases of an abnormal screening result. Umbilical artery Doppler investigation allows identifying those small-for-gestational-age foetuses at higher risk, and its use in these pregnancies improves a number of perinatal outcomes. Middle cerebral artery Doppler investigation reflects brain redistribution, and its use in combination with the umbilical artery in a cerebroplacental ratio seems to improve prediction of adverse outcome, mainly in near-term pregnancies, where most instances of adverse outcome occur in foetuses with normal umbilical artery. Ductus venosus Doppler waveform is a surrogate parameter of the foetal acid-base status. However, the benefits of its use in the management of early-onset growth restriction needs further evidence.