Infection is defined as recovery of vaccine virus from the blood or serum of a participant and/or by developing seropositivity to DEN virus (plaque reduction neutralization titer [PRNT]50 greater than or equal to 1:10). (clinicaltrials.gov)

Dengue vaccine development has made significant strides, but a better understanding of how vaccine-induced immune responses correlate with vaccine efficacy can greatly accelerate development, testing, and deployment as well as ameliorate potential risks and safety concerns. (semanticscholar.org)

We conclude that the evidence base is adequate to argue for inclusion of assessments of cell-mediated immunity as part of clinical trials of dengue vaccines, although further research to identify useful correlates of protective immunity is needed. (semanticscholar.org)

MANILA - The Philippines ordered a probe on Monday into the immunisation of more than 730,000 children with a dengue vaccine that has since been suspended, while French drug company Sanofi said no deaths had been reported as a result of the programme. (centerforvaccineethicsandpolicy.net)

In the new analysis of a five-year follow-up study, the increased risk translated to two more cases of "severe dengue" per 1,000 people who had not been exposed to the virus, the company's spokesperson told FiercePharma. (centerforvaccineethicsandpolicy.net)