Hemodynamic coherence in critically ill pediatric patients.
Differences in physiology and pathophysiology make the treatment of developing, critically ill children particularly challenging as compared to that of adults. Significant differences in the cardiovascular system of neonates and children in size, weight, body proportions, and metabolism should be considered. Hemodynamic monitoring is crucial for early warning of pending deterioration and to guide therapy. Current monitoring is limited to the macrocirculation, but an adequately functioning macrocirculation does not guarantee a well-functioning microcirculation. Research in children revealed loss of hemodynamic coherence, i.e., microcirculatory alterations despite normal systemic hemodynamics. Implementing the framework of hemodynamic coherence in microcirculatory monitoring in children can aid physicians in titrating therapy on both macrocirculatory and microcirculatory effects to assure optimal oxygen delivery. Monitoring the microcirculation at the bedside requires further technical development. Although more research is necessary to validate the concept of hemodynamic coherence in children, the possibilities of applying this concept in children seem promising.