The word Ormiston is derived from a half mythical Anglian settler called Ormr, meaning 'serpent' or 'snake'. 'Ormres' family had possession of the land during the 12th and 13th centuries. Ormiston or 'Ormistoun' is not an uncommon surname, and Ormr also survives in some English placenames such as Ormskirk and Ormesby.
The latter part of the name, formerly spelt 'toun', is likely to descend from its Northumbrian Old English and later Scots meaning as 'farmstead' or 'farm and outbuildings' rather than the meaning 'town'.

There was an "Ormiston" in Berwickshire, near Linton, where the legend of the Worm of Linton was related to land ownership by Lord Somerville and Lord Lindsay. The Cockburn family may have brought the name from the Berwickshire "Ormiston" to the East Lothian location in the 14th-century.

William Begg, Robert Burns's nephew became the parish schoolmaster at Ormiston.[1] The whole Begg family moved to live with him at Ormiston's schoolhouse. Isabella Begg nee Burns also ran a school here. The family later moved to nearby Tranent in 1834 when William resigned his post[2] and emigrated to America.[3]

The village consists mainly of a broad Main Street, with a row of mostly two storey houses along each side. It crosses two bridges, one over the now redundant railway route, and the other a narrow bridge over the river Tyne. Using strict guidelines for its appearance, John Cockburn put housing for artisans and cottage industries (spinning and weaving) around the original mill hamlet. When he did not achieve the expected return on his investment, he sold it to the Earl of Hopetoun in 1747. The linen trade became a failure, and by 1811 the distillery shut down. A brewery and one of Scotland's first bleachfields were also built here as well. Ormiston later became a mining village. The Ormiston Coal Company's workings were south of Tranent in East Lothian. The company was one of a number of small concerns working either a single or a few linked, small pits on the East Lothian coalfield. ([4]).

Ormiston Hall lay to the south of the village. It was built for John Cockburn in 1745–48 and was later extended for the Earl of Hopetoun. It was added to on at least three occasions in the next 100 years. The Hall now lies in ruins following a fire during World War II[5] with residential properties built in and around the grounds.

The remains of the pre-Reformation St Giles Parish Church can still be seen nearby. The Great Yew of Ormiston grows to the south of the hall site. It is a rare example of a layering yew-tree and, according to the Forestry Commission, is up to one thousand years old.[6]

Birthplace of the Scottish Congregationalist missionary Robert Moffat (1795-1883); a memorial is erected in his name. He was the father-in-law of David Livingstone, the medical missionary and explorer. His father was a custom house officer; the family of his mother, Ann Gardiner, had lived for several generations at Ormiston.[7]