Four randomized double-blind clinical trials were carried out to assess the effectiveness and safety of rt-PA use in ischemic CVA: National Institute of Neurological Disorders and Stroke NINDS trial, the first and second European cooperative Acute Stroke Studies ECASS I e ECASSII and Alteplase Thrombolysis for Acute Non-interventional Therapy in Ischemic Stroke ATLANTIS Study.
Fueron realizados cuatro ensayos clínicos doble-ciegos randomizados para evaluación de la eficacia y seguridad del uso de rt-PA en AVC isquémico: National Institute of Neurological Disorders and Stroke NINDS trial, el primero y el segundo European co-operative Acute Stroke Studies ECASS I e ECASSII y Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke ATLANTIS Study.
Foram realizados quatro ensaios clínicos duplo-cegos randomizados para avaliação da eficácia e segurança do uso do rt-PA no AVC isquêmico: National Institute of Neurological Disorders and Stroke NINDS trial, o primeiro e o segundo European co-operative Acute Stroke Studies ECASS I e ECASSII e Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke ATLANTIS Study.