Two studies, Fluvastatin On Risk Diminishment after Acute Myocardial Infarction FLORIDAand Pravastatin in Acute Coronary Treatment PACT have tested the use of moderate doses of statins with disappointing results in relation to the outcomes of death, myocardial infarction and recurrent angina despite significant reduction in serum levels of LDL cholesterol.
Dos estudios, el Fluvastatin On Risk Diminishment after Acute Myocardial Infarction FLORIDAy el Pravastatin in Acute Coronary Treatment PACT testaron el uso de dosis moderadas de estatinas con resultados decepcionantes con relación a los desenlaces muerte, infarto y angina recurrente, a pesar de la reducción significativa de las tasas séricas de colesterol LDL.
O estudo FLORIDA envolveu 540 pacientes randomizados para receber 80 mg ao dia de fluvastatina ou placebo dentro de 15 dias do evento agudo, com seguimento de 12 meses.