Most of experimental findings indicate that the preservation of mitochondrial function, which is due to the activation of potassium ATP-dependent channels, is vital for the cardioprotective effects against ischemia, as it reduces intracellular calcium overload, preserves energy reserves more efficiently and prevents the activation of the effects that cause apoptosis and cellular necrosis.
Se produce la reducción en la sobrecarga de calcio intracelular, mejor preservación de las reservas de energía y prevención de la activación de efectos promotores de la apoptosis y necrosis celular.
Ocorre redução na sobrecarga de cálcio intracelular, melhor preservação das reservas de energia e prevenção da ativação de efeitos promotores da apoptose e da necrose celular.