This accumulation leads to retardation of growth and sexual maturation, endocrine abnormalities, among other problems, although cardiac complications are more severe and account for 50% of deaths.
Sin embargo, las complicaciones cardíacas son las más graves y responsables por 50% de las muertes.
Esse acúmulo acarreta retardo no crescimento e na maturidade sexual, anormalidades endocrinológicas, e outros problemas. Porém, as complicações cardíacas são as mais graves e responsáveis por 50% das mortes.