These subsequent studies indicated that the up-regulation of COX-2 has a key-role in cardioprotection mediated by PGE2 and PGI2.
Estudios subsiguientes indicaron que la regulación superior de la COX-2 desempeña rol-clave en la cardioprotección mediada por las PGE2 y PGI2.
Estudos subsequentes indicaram que a regulação superior da COX-2 desempenha papel-chave na cardioproteção mediada pelas PGE2 e PGI2 .