El Ayass and Hendrickx found a reduction of mivacurium infusion rate and a delay in neuromuscular recovery after metoclopramide 10 or 20 mg in their randomised double blind placebo-controlled study of 45 patients. There was no significant change in the onset time compared to saline, probably due to an inadequate number of patients. Plasma cholinesterase level decreased in both metoclopramide groups. The recovery indices were greater with metoclopramide compared to saline. While there were significant increases in the time to recovery at 25%, 50%, 75% and 90% with 20 mg, there was only 75% and 90% increase in the time of recovery with 10 mg, compared to saline.
En su estudio aleatorizado, doble ciego y controlado por placebo de 45 pacientes, El Ayass y Hendrickx observaron una reducción de la infusión de mivacurio y un retardo en la recuperación neuromuscular después de la administración de la metoclopramida 10 ó 20 mg. No hubo cambios significativos en el tiempo hasta la recuperación en los niveles de 25%, 50%, 75% y 90% con metoclopramida 20 mg; ocurrió un aumento solamente en los niveles de 75% y 90% en el tiempo hasta la recuperación con 10 mg, en comparación con la salina.
Não houve mudança significativa no tempo até a recuperação nos níveis de 25%, 50%, 75% e 90% com metoclopramida 20 mg; ocorreu aumento apenas nos níveis de 75% e 90% no tempo até a recuperação com 10 mg, em comparação com salina.