A 55-yr-old male presented with acute chest pain, dyspnea, and hypotension on December 8, 2009. The patient has been followed without any medications for incidentally detected asymptomatic SVC aneurysm for last 2 yr (, and the size of the SVC aneurysm did not change (). Chest radiography at admission showed marked widening of the right middle mediastinum due to abnormal soft-tissue density suggesting the rapid expansion of previously noted SVC aneurysm (). Echocardiography revealed marked enlargement and hypokinesia of the right ventricle (RV) with moderate pulmonary hypertension suggesting acute PE. Chest computed tomographic angiography (CTA) showed about 6.9 × 6.1 × 9.9 cm sized lobulated giant saccular aneurysm originating from mainly SVC and partially involving left brachiocephalic vein with internal thrombi (). Considerable amounts of thromboembolic filling defects in left pulmonary artery, both left and right lobar, segmental, and subsegmental arteries were also noted (). Three-dimensional reconstruction with endovascular views showed the giant saccular SVC aneurysm with 4.1 × 3.7 cm sized internal thrombi, and the thrombi protruded into the SVC through the narrow aneurysmal neck (). Venous CTA of the lower extremities and abdominal CTA showed no evidence of deep vein thrombosis or other venous aneurysms. To exclude the possible hypercoagulable status as a cause of pulmonary thromboembolism, the laboratory tests for hypercoagulability was done and revealed no abnormalities. Surgical exclusion of SVC aneurysm with pulmonary embolectomy was planned, but the patient and family refused surgery. Therefore, thrombolytic therapy using recombinant tissue plasminogen activator with the dose of 200 mg was administered intravenously for 2 hr for hemodynamically significant PTE, and the RV function and pulmonary artery pressure was normalized on FU echocardiography. However, the patient complained recurrent chest pain and dyspnea on the next day. FU CTA revealed more decreased amounts of thrombi in the left pulmonary artery and its branches, but the amounts of thrombi in the SVC aneurysm, SVC, right pulmonary artery and its branches were increased. Mobilization of thrombi from the SVC aneurysm due to thrombolytic therapy was the possible cause of recurrent PTE, and it was expected that further embolization of thrombi would be fatal to the patient. Therefore, surgical treatment was strongly recommended. Resection of SVC aneurysm and pulmonary artery embolectomy were performed successfully. At surgery, femoral arterial and venous cannulation was done to prepare for accidental rupture of aneurysm during sternotomy. After dissection of the aneurysm, the other venous cannulation at the innominate vein and isolation of the proximal and distal portion of the aneurysm was done. Under cardiopulmonary bypass, aneurysmal wall was opened longitudinally after snaring of proximal and distal portion of the aneurysm and innominate vein. Aenurysm which contained fresh thrombi was thin-walled and had relatively normal venous endothelium grossly (), and the histopathologic examination showed compatible findings of true aneurysm (). Thin-walled aneurysmal wall was completely resected and subsequent reconstruction of the superior vena cava was performed with glutaraldehyde fixed autologuous pericardium that was already harvested. Outer surface of the pericardium was buttressed with Dacron to prevent potential formation of pseudoaneurysm. A transverse arteriotomy was made in the pulmonary trunk to the left main pulmonary artery and another incision was made in the right main pulmonary artery, and the fresh and organized thrombi were gently extracted. Following the successful surgical management, the mediastinal widening on chest radiography was normalized () and the patient was recovered without any postoperative events. The patient was discharged and treated by anticoagulation with warfarin for 6 months to achieve complete resolution of the possible remained pulmonary arterial thrombi.
A 52-year-old man was admitted to our hospital for mediastinal mass found incidentally in health examination. He had no special disease history or any symptoms. No face or upper extremity edema was found in physical examination. Enhanced chest computer tomography (CT) showed a size of 5.6*4.3 cm mass in anterior mediastinum, which was enhanced in the artery phase (Fig. ), and it had no clear boundary with left innominate vein and SVC. The CT report suggested high possibility of thymoma. Echocardiographic examination did not reveal any abnormality. Thymoma was diagnosed and he received operation in our hospital through median sternotomy on July 2019. During the operation, a dark red and saccular mass was found in anterior mediastinum with slight pulsation. The mass had no clear boundary with left innominate vein and further exploration revealed they were connected with each other. The membrane of the mass seemed to be very thin and easily bled when touched. Left innominate venous aneurysm with part of SVC involved was highly suspected.\nThe venous aneurysm was resected with the proximal and distal end of the left innominate vein blocked (Fig. ). However, the majority of the left innominate vein wall was involved and only a little part of vessel wall was left after the venous aneurysm was resected, which made the reconstruction of the left innominate vein necessary. Because of the misdiagnosis and lack of abundant preoperative preparation, we decided to take pericardium as material for repairment and reconstruction. We first resected the involved part of SVC with it blocked, and repaired it with a small piece of pericardium. The SVC was unblocked immediately after repairment was finished. Then we took a large piece of pericardium and wrapped it around a needle tube, suturing the two sides to make it a tube in shape with the smooth surface inside (Fig. ). The tube was first anastomosed to the distal end of the left innominate vein. Then we blocked the SVC again and opened a small hole in the side wall and anastomosed the other side of the tube with SVC. The reconstructed left innominate vein and SVC seemed patent and firm (Fig. ). Low molecular heparin was used once per day just for routine anticoagulation after surgery. The patient had an uneventful postoperative course and was discharged 6 days after surgery. He did not take anticoagulant drugs after discharge and was satisfied with the treatment therapy. The pathological diagnosis was mediastinal hemangioma. The patient kept in good condition on the last follow up date of December 2019.