A 19-year-old male admitted for possible meningitis presented with numbness and fever and developed acute paraplegia secondary to a spinal abscess. Surgical and blood cultures revealed MSSA on day 1, then the patient developed sepsis secondary to a pulmonary septic embolus. Vancomycin was discontinued, and oxacillin 2 g every 4 h was initiated on day 4. He had negative blood cultures on day 6. On day 14, he was discharged to rehabilitation on ceftriaxone 2 g every 24 h for 8 weeks.
A 35-year-old female was admitted for fever with swelling and pain at the site of the peripherally inserted central catheter (PICC) in her left arm. She had a PMH of gastroparesis with multiple abdominal surgeries and was reliant on total parenteral nutrition. Blood cultures revealed MSSA, and her PICC was removed for 48 h before a new one was placed. She received ceftriaxone 1 g every 24 h on days 1–3. Ceftriaxone was switched to oxacillin 2 g every 6 h on day 4. She was changed back to ceftriaxone 2 g every 24 h on day 12, then discharged to a long-term acute care (LTAC) facility on day 23. She continued ceftriaxone at LTAC for 8 additional days.