We report a 63-year-old Asian female with no significant past medical history, who presented to our clinic reporting an eight-week history of abdominal pain, anorexia, and weight loss. The abdominal pain was mild to moderate, crampy in nature and generalized. It was aggravated with food intake and partially relieved with proton pump inhibitors and probiotics. It was associated with nausea, bloating and an unintentional weight loss of five kilograms in six months. She denied any fever, skin rash, chronic diarrhea or rectal bleeding. She reported traveling back and forth from Hawaii to the Philippines many times before she moved to Florida one year prior. Her physical examination was unremarkable. Her complete blood count and metabolic profile were unremarkable except for a borderline normocytic anemia (hemoglobin at 11.7g/dL). Urine analysis and routine ova and parasites exams in both urine and stool were negative. Right upper quadrant ultrasound was unrevealing. Esophagogastroduodenoscopy (EGD) was unremarkable, as shown in Figure , while colonoscopy showed a 10 milimeter (mm) flat polyp in the descending colon which underwent endoscopic mucosal resection (EMR). Pathology showed hyperplastic colon mucosa with numerous parasite eggs deposition in the submucosa, consistent with Schistosoma species (Figure ). The patient was then treated with Praziquantel (1800 mg in divided doses for one day) and her symptoms, including abdominal pain and bloating, were reported to improve. She also started to gain weight as noted in the two-week follow up visit.\n​​​​​​​
A 47-year-old man known to have hypothyroidism and hypertension on treatment presented to the gastroenterology clinic complaining of two-year history of abdominal distension that was worse after oral intake especially milk. He had normal bowel motions and denied nausea and vomiting. There was no previous abdominal surgery. On examination, the abdomen was distended with no tenderness. Colonoscopy was done and showed normal rectum, grossly dilated sigmoid with redundant colonic wall, and mild mucosal inflammation. Abdomen computerized tomography showed distended sigmoid colon with collapsed rectum and no obstruction ().\nAs his symptoms were severe and he already failed conservative management, the patient was referred to general surgery. He underwent laparotomy () and extended hemicolectomy of the affected segment, with colorectal anastomosis. He did well intra- and postoperatively. The pathology unexpectedly showed chronic schistosomiasis in the colonic wall (Figures and ). Upon further evaluation, we found that he lived in the north of Saudi Arabia (Hail) but denied exposure to unclean water or recent travel. His Schistosoma serology titer was high (1 : 1024). Other laboratory findings included slightly elevated direct and total bilirubin (12.3 and 41.5 μmol/L, respectively), normal aminotransferases, erythrocyte sedimentation rate = 11 mm/hour, and C-reactive protein < 3.50 mg/L. He was referred to the infectious disease clinic and was treated with praziquantel. At six-month follow-up, the patient was doing well with resolution of his abdominal symptoms.