An 8-year-old girl presented to the Leishmaniasis research laboratory of the Fajr Health Center with complaint of wound on her upper lip. The lesion started 3 months prior as a small nodule in the center of the upper lip which slowly enlarged over a few weeks and then ulcerated. Clinical examination showed an indurated, crusted, and scaled necrotic ulcer with swelling on the midline of the upper lip, extending to the vermilion. There was purulent discharge from the lesion (Fig. f). With suspicion of cheilitis granulomatosa, slit dermal scraping, culture and PCR were performed. Giemsa-stained smear and culture were positive. PCR portrayed the parasite as L. major.
A 75-year-old woman came to the Dermatology Clinic of Saadi Hospital complaining about a lesion on his right lower lip. She reported that the lesion appeared about 3 months before. The clinical examination revealed a round nodular lesion in the right lower lip which was slightly shiny and red colored. Palpation of the lesion revealed a firm consistency (Fig. ). The differential diagnosis of a nodular lesion of the lip included: neoplasia (basal cell carcinoma), and tumors from mesenchymal origin (fibroma, lipoma, and neuroma). Giemsa stain and culture were negative. PCR depicted the parasite as L. tropica.