Our patient is a 92-year-old male with severe aortic stenosis whose past medical history includes umbilical and inguinal hernia, chronic diastolic heart failure, right bundle branch block, coronary artery disease, and obesity. He became significantly symptomatic in the last few months prior to his admission to the hospital, where he complained of worsened dyspnea on exertion and recurrent syncopal attacks. Physical examination did not show any significant findings except for a 5/6 systolic ejection murmur in the aortic area radiating to both carotids. Diagnostic cardiac catheterization showed no evidence of coronary artery disease. Carotid Doppler showed no significant stenosis. Electrocardiogram showed sinus rhythm with a right bundle branch block. Transesophageal echocardiography showed critical aortic valve stenosis, mean pressure gradient of approximately 72 mmHg, valve area of 0.46 cm2, and left ventricular ejection fraction of 60%. A 29 mm Edwards SAPIEN XT valve was implanted via transfemoral access. Confirmation of position was then done by aortography. The transesophageal echocardiogram confirmed the adequate position of the valve with minimal aortic insufficiency. There was no pericardial effusion with normal ventricular systolic function. Postdeployment aortogram showed paravalvular leak and patent coronary arteries.\nPostdeployment hemodynamics showed zero mmHg mean gradient pressure between the left ventricle and the aorta with left ventricular end diastolic pressure (LVEDP) ~ 10 mmHg.\nPost-TAVR day 1 routine transthoracic echocardiography (TTE) showed well-seated and normally functioning bioprosthetic aortic valve with a small posterior paravalvular leak. It also showed a small-sized continuous (systolic and diastolic phases) shunt, which communicated with the aortic root into the right ventricle (aorto-RV shunt) (Figures and ).\nSince the patient was asymptomatic following the procedure, he was managed conservatively with close follow-up. His repeat TTE a month after the procedure revealed no significant change from his post-TAVR day 1 TTE (). Therefore, we decided to continue with medical management and close follow-up, since the patient was asymptomatic.\nFollow-up with TTE a year later showed persistence of the aorto-RV fistula and significant improvement in the velocity across the shunt (), which may be due to a decrease in the fistula size rather than an increase in RV pressure as RV systolic pressure (RVSP) remained within normal limits on follow-up TTE.
An 89-year-old male with a prior history of laryngeal cancer status after surgical resection and radiation therapy with residual dysphagia, coronary artery disease status after coronary artery bypass grafting in 1992, severe aortic stenosis status after balloon valvuloplasty in 2013, pulmonary fibrosis, COPD on 2-liter continuous home O2 therapy, and TIA presented in our clinic with several years of progressive dyspnea and angina with exertion. He was admitted in the hospital at least five times over the past one year with chest pain and dyspnea. Diagnostic cardiac catheterization was done showing three out of four grafts being patent (SVG-RPLV completely occluded). Last year, he underwent balloon aortic valvuloplasty with a 22 mm balloon for severe aortic stenosis and the patient reported partial relief of symptoms for approximately six months after the procedure but now the symptoms are progressively getting worse. Transthoracic echocardiogram (TTE) showed concentric left ventricular hypertrophy, left ventricular ejection fraction of 60%, right ventricle mildly dilated with preserved systolic function, pulmonary artery systolic pressure of 34 mmHg, heavily calcified aortic valve annulus, mean pressure gradient of 68 mmHg, velocity of 517 cm/sec, and aortic valve area of 0.62 cm2. Cardiothoracic surgery team evaluated him for aortic valve replacement but the surgeon felt that patient is at very high risk for open-heart surgery. Per our TAVR team, his aortic valve annulus was too big (anteroposterior diameter 2.6 cm and mediolateral diameter of 2.8 cm per transesophageal echocardiogram, ) for commercially available Core Valve (Medtronic, USA). Ultimately, our TAVR team used a 29 mm Edward Sapien valve via transfemoral access. The procedure was complicated by complete heart block requiring temporary pacemaker backup. A permanent pacemaker was placed after 24 hours. Repeat TTE showed moderately dilated right ventricle with moderately reduced systolic function, pulmonary artery systolic pressure of 40 mmHg, Sapien prosthesis in aortic position with mild perivalvular leak and mean gradient of 9 mmHg, moderate sized continuous (systolic and diastolic phases) shunt which communicates with the aortic root around the prosthesis into the RV (aorto-RV shunt), and pulmonary flow (Qp) to systemic flow (Qs) ratio of 1.39. The patient was managed conservatively with close follow-up. At 30-day follow-up, the patient remained moderately to severely dyspneic. Patient was offered percutaneous closure of the aorto-RV fistula using devices like septal occluder (Amplatzer device) but patient refused it. His repeat TTE showed worsening of aorto-RV fistula and it also showed new small membranous VSD (see Video 1 in the Supplementary Material available online at ), which was not visible on the first postprocedural TTE. His condition progressively got worse. He changed his code status to comfort measures only and passed away in a couple of days.