We present a case of 38-year-old woman who presented to our Dermatology OPD with complaints of palmoplantar thickening and scaling. During her childhood, she had noticed slight scaling localized to bilateral palms and soles which then progressed to become brownish honeycomb transgradient hyperkeratosis over a period of around ten years (Figure ; Figure ). It was associated with pain, tightening, and winter aggravation. She also had generalized dryness of the skin. However, she did not receive any treatment, and at the age of twenty-five years, she gradually developed a constriction band around the fifth toe which gradually tightened leading to pseudoainhum with amputation at the level of the proximal interphalangeal joint (Figure ). Her hearing, vision, hair, and nails were normal. Among her two children, the elder son is eleven years old and is also affected and the younger daughter is unaffected till this date. Considering the presence of transgradient honeycomb keratoderma with generalized ichthyosis and pseudoainhum in the absence of deafness, a diagnosis of Camisa syndrome was made.
A 52-year-old healthy woman, sought assistance for thickened palms and soles which began\nin her childhood, as well as changes in one of her toes, which began a few years ago.\nShe was the third of five generations involved. Her mother had a finger amputated due to\nthe evolution of the same disease. Physical examination detected transgredient, diffuse\npalmoplantar hyperkeratosis, with constrictive bands on the fifth toe (left)\n(pseudo-ainhum) - generalized ichthyosiform dermatosis with no hearing loss (, \nand ). Anatomopathological examination of the\npalmar region found hyperkeratosis with orthokeratosis and parakeratosis ().