A 25-year old male with uncontrolled asthma. Initial FEV1 was 2.51 L (62.6%) and severe sputum eosinophilia. His CT scan shows diffuse bronchitis with tree bud sign and then treated with clarithromycin for 9 months. FEV1was improved from 62.6% to 88.4%. He reduced daily amount of inhaled corticosteroid.
A 52-year old male complained his uncontrolled asthma for 4years. He was diagnosed as severe asthma and treated at other hospital. His FEV1 was 1.74L (54.4%) and improved 20.6% after bronchodilator. CT scan showed diffuse bronchiolitis thus we adminster clarithromycin for 6 months. FEV1was improved from 54.4% to 95.3%. He could discontinue inhaledcorticosteroid and other asthma medications.