A 66-year-old white woman presented for an evaluation of her skin. Informed consent was obtained from the patient for being included in the study. Additional informed consent was obtained from all patients for which identifying information is included in this article. The patient’s past medical history was significant for systemic lupus erythematosus and myasthenia gravis. Since 1980, the patient has been treated with hydroxychloroquine at a daily dose of 400 mg.\nThere was diffuse hyperpigmentation. The patient’s forehead, face, neck, v-area of the upper central chest, and upper back were black (Figs. , ), and her right upper chest was blue (Figs. , ). Hyperpigmentation was absent from her oral mucosa and nails.\nFive years earlier, the patient had visited a new clinician on a Friday afternoon. The patient’s clinician misinterpreted her black and blue dyschromia to be trauma-induced and had notified Adult Protective Services. The following Monday morning, a worker from the agency was at her home to investigate the family for elder abuse. Eventually the situation was resolved and the family was cleared of all suspicion of elder abuse.\nDuring her current cutaneous evaluation, a skin biopsy from the area of blue dyschromia on the patient’s right upper chest was performed. Microscopic examination showed both intracellular and extracellular yellow-to-brown granules scattered throughout the reticular dermis. Pigmented granules were seen between the collagen bundles with some accentuation around eccrine glands. The granules stained positively for both Fontana Masson and Perl’s stains.\nCorrelation of the patient’s medical history, clinical presentation, and pathology findings confirmed the diagnosis of hydroxychloroquine-induced hyperpigmentation.
Male patient, 30 years old, white, born and living in Rio de Janeiro, RJ, Brazil,\ncomplained of intense pruritus followed by disseminated erythematous lesions with onset\nless than 24 hours before. He had no history of associated diseases, use of any\nmedications or any other associated factors. On the first inspection we noted small\nerythematous papules and some petechiae that assumed a linear pattern located on the\ntrunk, lower and upper limbs. There were no mucosal abnormalities, fever or any other\nsystemic symptoms ( and ). Based on the peculiar rash, the patient was\nquestioned about the ingestion of shiitake and confirmed he had eaten a\nlarge amount of raw mushrooms five hours before the cutaneous lesions appeared, leading\nus to the diagnosis of flagellate erythema due to shiitake\ningestion.