A 54-year-old female, a known case of rheumatic heart disease with severe mitral stenosis, MV area was 0.9 cm2, and moderate mitral regurgitation, was admitted to our hospital. The MV and subvalvular apparatus were calcified and there was moderate pulmonary arterial hypertension. Bilateral ventricular functions were within normal limits. She was posted for MV replacement (MVR) and informed consent was obtained. Her preoperative hematological investigations were within normal limits. General anesthesia was induced with standard medications and cardiopulmonary bypass (CPB) was established.\nShe underwent MVR with bioprosthetic valve 25 mm (EPIC, St. Jude Medical). Immediate post-CPB TEE showed normal functioning prosthetic valve and Doppler also revealed normal pressure gradients across the valve []. Her intraoperative period was uneventful and shifted to postoperative Intensive Care Unit (ICU) with minimal doses of inotropes. Postoperative day (POD) 0 was uneventful; however, on POD 1, she developed hypotension (arterial pressure 84/50 mmHg) that required increasing doses of inotropic support. Her central venous pressure was 20 mmHg and pulmonary artery pressure was 60/38 mmHg. Arterial blood gases also revealed metabolic acidosis. Due to her hemodynamic status, she could not be weaned off the mechanical ventilation.\nTEE was done to rule out cardiac tamponade and to evaluate the prosthetic MV function. It revealed a large cavitatory mass occupying the whole of left atrium (LA) which was obliterating the movement of MV leaflets [ and ]. Continuous wave Doppler (CWD) showed pressure gradient (peak/mean) of 19/10 mmHg across MV []. However, bilateral ventricular functions were within normal limits.\nOwing to her deteriorating hemodynamic condition, she was immediately shifted to the operating room. Chest was reopened and CPB was established. Opening of LA revealed dissection of the LA wall extending from the posterior annulus of the MV to the roof of LA. Clots were removed from the LA; however, the cavity again filled up. Therefore, it was decided to do the “marsupialization” for clearing of the cavity [ and ]. The bioprosthetic valve was also examined and was found to be normal. CWD also revealed normal gradient across prosthetic MV []. The patient was weaned off the CPB with low dose of inotropes. She was mechanically ventilated for 24 h and inotropes were gradually weaned off. She had longer stay in the ICU; otherwise her postoperative period was uneventful.
A 69-year-old man was admitted in our hospital due to fever, chill, orthopnea and paroxysmal nocturnal dyspnea. In physical examination, respiratory sounds were reduced in both his lower half of lung fields.\nHe had undergone a major cardiac surgery including CABG, MVR, aortic valve replacement (AVR) and ascending aorta replacement due to severe coronary artery disease, significant valvular heart disease (rheumatic) and aneurysmally dilated ascending aorta, 75 days prior to his recent admission.\nAn electrocardiogram revealed atrial fibrillation rhythm, normal axis and non-specific ST-T changes in inferior and lateral leads (). The posteroanterior view of the chest radiography showed massive bilateral pleural effusion. Transthoracic echocardiography followed by TEE showed normal LV size with preserved systolic function, bioprosthetic MV with acceptable hemodynamic and mobility and no paravalvular regurgitation. Bioprosthetic AV had acceptable hemodynamic and mobility without paravalvular regurgitation. There was normal functioning ascending aorta Dacron tube graft without leakage from proximal and distal part of prosthesis.\nThe LA was enlarged and dissection was found on the posterior wall. Two homogenous particles (1.18 × 0.4 cm and 0.9 × 0.58 cm) were attached to the dissecting flaps which were highly suggestive for vegetations and IE (, , and , , , and ).\nLaboratory tests showed severe coagulopathy, high levels of fibrin degradation products, leukocytosis (white blood cells count: 26700/cm3, predominantly poly morphonucleated), severe anemia, thrombocytopenia, elevated liver enzymes and serum creatinine levels. These data were suggestive for DIC. The blood culture revealed enterococci septicemia.\nHis general condition deteriorated rapidly. He suffered from tonic-clonic seizures, diminished consciousness, widespread mucosal bleeding and oliguria. Bilateral chest tubes were inserted for massive pleural effusion. The patient was treated with intravenous vancomycin, cefepim, gentamycin and oral rifampin. He received infusion of fresh frozen plasma, packed cells, valproic acid, diazepam and phenytoin.\nBased on his poor general condition, cardiac surgery was not performed and finally he expired from multi organ failure. Autopsy findings were consistent with clinical, laboratory and echocardiographic findings.