A 52-year old male complained his uncontrolled asthma for 4years. He was diagnosed as severe asthma and treated at other hospital. His FEV1 was 1.74L (54.4%) and improved 20.6% after bronchodilator. CT scan showed diffuse bronchiolitis thus we adminster clarithromycin for 6 months. FEV1was improved from 54.4% to 95.3%. He could discontinue inhaledcorticosteroid and other asthma medications.
A 70-year old female came to our clinic complaining uncontrolled asthma for 10 years. Spirometry showed obstructive lesion (FEV1=94.9%, FEV1/FVC =71.08%) with 5% bronchodilator (BD) response. PC20 of methacholine was 3.8 mg/ml. Chest CT showed diffuse bronchial wall thickening with tree in bud sign. Treated with clarithromycin for 1 month, FEV1was improved from 64.9% to 84.2% without asthma medication.