A 35-year-old female with PMH of invasive breast carcinoma with reported tenderness around her chemotherapy port for 1 week was admitted for Gram-positive BSI. The chemotherapy port was removed on day 2 and cultured MSSA. Vancomycin was discontinued in favor of oxacillin 2 g every 4 h until day 5, when oxacillin was discontinued, and she was discharged on 2 weeks of ceftriaxone 2 g every 24 h.
A 66-year-old male with PMH including DM and hypertension (HTN) was admitted for septicemia secondary to cellulitis of the left great toe. He received vancomycin until day 3, when blood cultures revealed MSSA. Oxacillin 2 g every 4 h was administered from hospital days 4 through 7, then oxacillin was changed to ceftriaxone 2 g every 24 h for 4 weeks of therapy.