A 52-year old male complained his uncontrolled asthma for 4years. He was diagnosed as severe asthma and treated at other hospital. His FEV1 was 1.74L (54.4%) and improved 20.6% after bronchodilator. CT scan showed diffuse bronchiolitis thus we adminster clarithromycin for 6 months. FEV1was improved from 54.4% to 95.3%. He could discontinue inhaledcorticosteroid and other asthma medications.
A 60-year old female was visited to our clinic with severe asthma. Spirometry showed obstructive lesion (FEV1=42.9%, FEV1/FVC =73.37%) without BD response. CT scan shows diffuse bronchial wall thickening. FEV1was improved from 42.9% to 97.1 % after 6 months use of clarithromycin without any asthma medication.