Mrs. N, a 31-year-old pregnant woman at 40 weeks gestation, presented to our obstetric emergency unit with tachypnea (RR 30×/min; O2 saturation 93%) and fever (101.3 °F) for one week before admission. The patient had a history of flu-like symptoms and anosmia for the previous 2 weeks. A chest X-ray showed no appearance of pneumonia. Oxygen therapy was given with a nasal cannula, 4 Lpm, and O2 saturation was 96%. SARS-CoV-2 (RdRP Cq 24.40; E Gene Cq 23.89) was confirmed using RT-PCR from a naso-oropharyngeal swab.\nWe immediately conducted a cesarean section due to a premature rupture of the membrane with oligohydramnios. The cesarean section was successful, and a born baby boy was born, 3465 g, 51 cm, AS 8/9. The neonate was taken care of in the perinatal isolation unit for COVID-19, and a naso-oropharyngeal swab for SARS-CoV-2 result came back negative.\nThe patient was taken to the isolation ward for COVID-19 for postoperative observation. The patient was given Remdesivir on HD 2 until HD 6. The patient’s symptoms improved during hospitalization with a negative swab result for SARS-CoV-2 on hospital care day 6. Both patient and baby were discharged with a stable condition on HD 7.
Mrs. A, a 35-year-old at 27 weeks gestation, was referred to our institution with a fever (101.3 °F), flu-like syndrome, tachypnea (RR 28×/min; O2 saturation 94% room air), and anosmia. The patient had complained of symptoms for 4 days before admission. A chest X-ray was normal. A naso-oropharyngeal swab was positive for SARS-CoV-2 by real-time PCR (RdRP Cq 15.21; E Gene Cq 15.58) without abnormalities in a chest X-ray.\nThe patient was taken care of in an isolation ward for COVID-19 and given oxygen therapy 4 Lpm with a nasal cannula (saturation 96–97%). Remdesivir was given on HD 1 until HD 6. Daily fetal monitoring was performed using a fetal doppler and fetal kick count chart. During hospitalization, clinical symptoms improved. The patient was discharged after 7 days of hospitalization with a repeated naso-oropharyngeal swab for SARS-CoV-2 result which came back negative. The patient underwent vaginal delivery at 37 weeks gestation. A baby boy was born, 3100 g, 51 cm, A/S 8/9. Both mother and baby were in good condition after delivery.\nRemdesivir Protocol:\nDay 1: 200 mg IV single dose\nDay 2–5: 100 mg IV/daily