A 64-year-old female admitted for shortness of breath, weakness, and fatigue with a PMH of HTN, DM, heart failure, atrial fibrillation, and end-stage renal disease (ESRD) had positive MSSA blood cultures from admission. A definitive source for the MSSA BSI was not determined but assumed to be foreign body material (tunneled dialysis catheter, Foley catheter, and implantable cardiac device). She was initiated on ceftriaxone 2 g every 24 h on day 3 and cultures cleared on day 8. She received 4 weeks of ceftriaxone (25 days inpatient and 3 days outpatient).
A 47-year-old male admitted for MSSA septicemia secondary to a laceration repair on the back of the head 9 days prior had positive surgical site and blood cultures with MSSA. Oxacillin 2 g every 4 h was initiated on day 4. Echocardiogram was negative for vegetations, and on day 11, antimicrobial therapy was switched to ceftriaxone 2 g every 24 h for 6 weeks of therapy.