A 35-year-old female with PMH of invasive breast carcinoma with reported tenderness around her chemotherapy port for 1 week was admitted for Gram-positive BSI. The chemotherapy port was removed on day 2 and cultured MSSA. Vancomycin was discontinued in favor of oxacillin 2 g every 4 h until day 5, when oxacillin was discontinued, and she was discharged on 2 weeks of ceftriaxone 2 g every 24 h.
A 47-year-old male admitted for MSSA septicemia secondary to a laceration repair on the back of the head 9 days prior had positive surgical site and blood cultures with MSSA. Oxacillin 2 g every 4 h was initiated on day 4. Echocardiogram was negative for vegetations, and on day 11, antimicrobial therapy was switched to ceftriaxone 2 g every 24 h for 6 weeks of therapy.