A 35-year-old female was admitted for fever with swelling and pain at the site of the peripherally inserted central catheter (PICC) in her left arm. She had a PMH of gastroparesis with multiple abdominal surgeries and was reliant on total parenteral nutrition. Blood cultures revealed MSSA, and her PICC was removed for 48 h before a new one was placed. She received ceftriaxone 1 g every 24 h on days 1–3. Ceftriaxone was switched to oxacillin 2 g every 6 h on day 4. She was changed back to ceftriaxone 2 g every 24 h on day 12, then discharged to a long-term acute care (LTAC) facility on day 23. She continued ceftriaxone at LTAC for 8 additional days.
A 35-year-old female with PMH of invasive breast carcinoma with reported tenderness around her chemotherapy port for 1 week was admitted for Gram-positive BSI. The chemotherapy port was removed on day 2 and cultured MSSA. Vancomycin was discontinued in favor of oxacillin 2 g every 4 h until day 5, when oxacillin was discontinued, and she was discharged on 2 weeks of ceftriaxone 2 g every 24 h.