A 48-year-old woman visited out-patient clinic of neurology after 2 weeks of headache. The localization of headache was mainly on right side of head. It showed as intermittent dull pain, especially at night. Headache was relieved after taking pain reliever. However, headache occurred again when she stopped taking medicine. The patient visited out-patient clinic of neurology again. There was no abnormal change in brain parenchyma after taking brain CT scan. However, occupying lesion was found in the right sphenoid sinus. This patient was immediately hospitalized in the Otolaryngology Department. Further paranasal sinus CT demonstrated abnormal density of the right sphenoid sinus with calcification and lesion on the sinus wall (Figure ). Patient was treated by transnasal endoscopic sphenoidotomy without antifungal therapy. Histopathological examination diagnosed right sphenoid sinus as SSFB (Figure ). No further recurrence of her headache was found after 14 months follow-up.
A 59-year-old woman visited out-patient clinic of neurology because of 3 years intermittent sharp pain on left orbital. She was diagnosed as trigeminal neuralgia in the community hospital. Then, she was treated with Carbamazepine, Mecobalamin and acupuncture, but without significant relief. Our examination found tenderness at the exit of the left supraorbital nerve. MRI imagine demonstrated that partial empty sella and left sphenoid sinus. This patient was referred to the Otolaryngology Department. Paranasal sinus CT demonstrated inflammation of left sphenoid sinus. Patient was treated by transnasal endoscopic sphenoidotomy without antifungal therapy. Histopathological examination diagnosed left sphenoid sinus as SSFB. Follow-up of 2 month demonstrated no further recurrence of her headache.\nAll of the major clinical information in patients with SSFB was summarized in the Table .