A 68-year-old female had positive blood cultures for MSSA and a paraspinal abscess, which was subsequently drained, and a TEE displayed a large vegetation on the right atrial junction. She was initially treated with oxacillin 2 g every 4 h from days 5 to 12. Negative blood cultures were obtained on day 9. On discharge (day 13), ceftriaxone 2 g every 24 h was initiated for completion of 6 weeks of therapy from first negative blood culture. Follow-up computed tomography (CT) scans showed that the paraspinal abscess resolved.
A 40-year-old female admitted for a BSI with an abscess on her left arm was hospitalized 2 days prior for new-onset DM. Blood cultures drawn on the day of discharge from the previous hospitalization grew MSSA. New blood cultures were obtained, and she was initiated on vancomycin therapy. On day 2, cultures revealed MSSA; vancomycin was discontinued, and oxacillin 2 g every 4 h was prescribed. On day 5, oxacillin was discontinued and she was discharged with ceftriaxone 2 g every 24 h to complete 4 weeks of therapy.