BH: A 50-year-old male presented with many bilateral LNs in the neck. Clinical preliminary diagnosis was lymphoma or metastasis. An assessment of the patient's file before the FNA MRI report revealed a description of a 22 mm × 18 mm asymmetrical mass lesion in the nasopharynx. Unfortunately, this information was not indicated on the FNA requisition form. US findings: the radiologist detected many conglomerated LNs in the right and left sides of the neck during the US before the FNA. An FNA was performed from the largest LNs located at the left and right supraclavicular regions, which were18 mm × 10 mm and 30 mm × 18 mm in size, respectively. Cytologic findings: malignant tumor cells were observed individually or in scattered groups on a lymphoid background and appeared reactive. Thin fusiform particles were detected inside the nucleus in some cells in malignant clusters []. Cytologic diagnosis: Undifferentiated malignant tumor. Comment: the cytologic differential included the metastasis of head/neck-associated carcinoma and Hodgkin's lymphoma due to atypical mononuclear cells in the reactive lymphoid background. Histopathology: the nasopharyngeal biopsy showed undifferentiated nasopharyngeal carcinoma.\nTHM: (1) Metastasis in the LNs in undifferentiated carcinoma of the nasopharynx involves diagnostic challenges during the FNA.[] This condition may be confused with other nonkeratinized carcinoma metastases and lymphomas (especially Hodgkin's lymphoma). (2) Bizarre cells observed in undifferentiated nasopharyngeal carcinoma may resemble atypical mononuclear cells in Hodgkin's lymphoma (Hodgkin cells) and Reed–Sternberg cells [].
BH: an FNA was requested for a 45-year-old female patient with multiple sclerosis due to the presence of an LN in the neck. Multiple LNs, the largest of which was 3 cm, were detected during the US. A US-FNA was performed on the dominant LN located in the left cervical region. Cytologic findings: homogenously spread monomorphic, large, round, atypical lymphoid cells were detected []. Cytologic diagnosis: Non-Hodgkin's lymphoma. Surgical biopsy and afterward: The biopsy from the neck was reported to be a “sebaceous cyst.” I wrote a letter to her physician and emphasized that there were bilateral multiple LNs in the neck and that the FNA picture did not reflect a “sebaceous cyst” at all. I called the patient 5 months later. After receiving my note, her physician excised the LN on which I had performed the FNA. The patient was diagnosed with “diffuse large B-cell lymphoma” and received treatment. It turned out that the mass described as a “sebaceous cyst” was removed by the physician, as it was easy to remove from the surface of the opposite side of the LNs that underwent FNA!