A 25-year old male with uncontrolled asthma. Initial FEV1 was 2.51 L (62.6%) and severe sputum eosinophilia. His CT scan shows diffuse bronchitis with tree bud sign and then treated with clarithromycin for 9 months. FEV1was improved from 62.6% to 88.4%. He reduced daily amount of inhaled corticosteroid.
A 60-year old female was visited to our clinic with severe asthma. Spirometry showed obstructive lesion (FEV1=42.9%, FEV1/FVC =73.37%) without BD response. CT scan shows diffuse bronchial wall thickening. FEV1was improved from 42.9% to 97.1 % after 6 months use of clarithromycin without any asthma medication.