human
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background Excessive alcohol use is a prevalent and worldwide problem . Excessive drinking causes a significant burden of disease and is associated with both morbidity and excess mortality . Prototype alteration and provision of a cue reminder could be useful strategies to enhance the effectiveness of online tailored interventions for excessive drinking . Objective Through a Web-based r and omized controlled trial , 2 strategies ( ie , prototype alteration and cue reminders ) within an existing online personalized feedback intervention ( Drinktest ) aim ed to reduce adults ’ excessive drinking . It was expected that both strategies would add to Drinktest and would result in reductions in alcohol consumption by intrinsic motivation and the seizure of opportunities to act . Methods Participants were recruited online and through printed material s. Excessive drinking adults ( N=2634 ) were r and omly assigned to 4 conditions : original Drinktest , Drinktest plus prototype alteration , Drinktest plus cue reminder , and Drinktest plus prototype alteration and cue reminder . Evaluation took place at 1-month posttest and 6-month follow-up . Differences in drinking behavior , intentions , and behavioral willingness ( ie , primary outcomes ) were assessed by means of longitudinal multilevel analyses using a last observation carried forward method . Measures were based on self-reports . Results All conditions showed reductions in drinking behavior and willingness to drink , and increased intentions to reduce drinking .  Prototype alteration ( B=–0.15 , P<.05 ) and cue reminder usage ( B=–0.15 , P<.05 ) were both more effective in reducing alcohol consumption than when these strategies were not provided . Combining the strategies did not produce a synergistic effect . No differences across conditions were found regarding intentions or willingness . Conclusions Although individuals ’ awareness of their cue was reasonable , their reported alcohol consumption was nevertheless reduced . Individuals appeared to distance their self-image from heavier drinking prototypes . Thus , prototype alteration and cue reminder usage may be feasible and simple intervention strategies to promote reductions in alcohol consumption among adults , with an effect up to 6 months . Trial Registration Nederl and s Trial Register ( NTR ) : 4169 ; http://www.trialregister.nl/trialreg/admin/ rct view.asp?TC=4169 ( Archived by WebCite at http://www.webcitation.org/6VD2jnxmB ) OBJECTIVE Design ated drivers  are a popular strategy for avoiding drunk driving . However , studies have demonstrated that the strategy is often implemented poorly , result ing in diminished risk-reduction effectiveness . The purpose of this study was to test the efficacy of six interventions design ed to reduce alcohol consumption among design ated drivers . METHOD A total of 376 groups consisting of 1,412 pedestrians ( 57.8 % men ) were recruited as they crossed into Tijuana , Mexico , from San Diego , CA . Before crossing into Mexico , each group was assigned at r and om to one of six experimental conditions or to one control condition . The six interventions were design ed to ( 1 ) cue the use of design ated drivers , ( 2 ) change attitudes about design ated drivers , ( 3 ) provide monetary rewards for driver sobriety , and ( 4 ) increase group supportive norms for proper design ated driver use . Participant breath alcohol concentrations ( BrACs ) were collected before entering Mexico and on return to the United States . RESULTS Using group members to deliver pro- design ated driver messages significantly decreased driver and passenger BrACs relative to controls . Male drivers were more likely to return from Mexico with BrACs of zero if they were rewarded . Among female drivers , wearing a bracelet with the printed words " design ated driver " in addition to cuing result ed in 9 of 10 drivers returning with BrACs equal to zero . CONCLUSIONS These results demonstrate that design ated driver sobriety can be enhanced through brief interventions , and proper use of the design ated driver concept did not increase the risk of excessive alcohol consumption for passengers 
    Output:
    
agent
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background Excessive alcohol use is a prevalent and worldwide problem . Excessive drinking causes a significant burden of disease and is associated with both morbidity and excess mortality . Prototype alteration and provision of a cue reminder could be useful strategies to enhance the effectiveness of online tailored interventions for excessive drinking . Objective Through a Web-based r and omized controlled trial , 2 strategies ( ie , prototype alteration and cue reminders ) within an existing online personalized feedback intervention ( Drinktest ) aim ed to reduce adults ’ excessive drinking . It was expected that both strategies would add to Drinktest and would result in reductions in alcohol consumption by intrinsic motivation and the seizure of opportunities to act . Methods Participants were recruited online and through printed material s. Excessive drinking adults ( N=2634 ) were r and omly assigned to 4 conditions : original Drinktest , Drinktest plus prototype alteration , Drinktest plus cue reminder , and Drinktest plus prototype alteration and cue reminder . Evaluation took place at 1-month posttest and 6-month follow-up . Differences in drinking behavior , intentions , and behavioral willingness ( ie , primary outcomes ) were assessed by means of longitudinal multilevel analyses using a last observation carried forward method . Measures were based on self-reports . Results All conditions showed reductions in drinking behavior and willingness to drink , and increased intentions to reduce drinking .  Prototype alteration ( B=–0.15 , P<.05 ) and cue reminder usage ( B=–0.15 , P<.05 ) were both more effective in reducing alcohol consumption than when these strategies were not provided . Combining the strategies did not produce a synergistic effect . No differences across conditions were found regarding intentions or willingness . Conclusions Although individuals ’ awareness of their cue was reasonable , their reported alcohol consumption was nevertheless reduced . Individuals appeared to distance their self-image from heavier drinking prototypes . Thus , prototype alteration and cue reminder usage may be feasible and simple intervention strategies to promote reductions in alcohol consumption among adults , with an effect up to 6 months . Trial Registration Nederl and s Trial Register ( NTR ) : 4169 ; http://www.trialregister.nl/trialreg/admin/ rct view.asp?TC=4169 ( Archived by WebCite at http://www.webcitation.org/6VD2jnxmB ) OBJECTIVE Design ated drivers  are a popular strategy for avoiding drunk driving . However , studies have demonstrated that the strategy is often implemented poorly , result ing in diminished risk-reduction effectiveness . The purpose of this study was to test the efficacy of six interventions design ed to reduce alcohol consumption among design ated drivers . METHOD A total of 376 groups consisting of 1,412 pedestrians ( 57.8 % men ) were recruited as they crossed into Tijuana , Mexico , from San Diego , CA . Before crossing into Mexico , each group was assigned at r and om to one of six experimental conditions or to one control condition . The six interventions were design ed to ( 1 ) cue the use of design ated drivers , ( 2 ) change attitudes about design ated drivers , ( 3 ) provide monetary rewards for driver sobriety , and ( 4 ) increase group supportive norms for proper design ated driver use . Participant breath alcohol concentrations ( BrACs ) were collected before entering Mexico and on return to the United States . RESULTS Using group members to deliver pro- design ated driver messages significantly decreased driver and passenger BrACs relative to controls . Male drivers were more likely to return from Mexico with BrACs of zero if they were rewarded . Among female drivers , wearing a bracelet with the printed words " design ated driver " in addition to cuing result ed in 9 of 10 drivers returning with BrACs equal to zero . CONCLUSIONS These results demonstrate that design ated driver sobriety can be enhanced through brief interventions , and proper use of the design ated driver concept did not increase the risk of excessive alcohol consumption for passengers 
    Output:
    