human
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Objectives : We assessed the effect of using preoperative sodium fluoride ( NaF ) on the difficulty of working with the footplate during stapedectomy and its effect on the postsurgical hearing gain in patients with mixed otosclerosis ( ie , otosclerosis and /or otospongiosis ) . Methods : There were 2 groups of patients with mixed otosclerosis . The experimental group was made up of patients with an active focus of the disease ; they received NaF for 6 months and then underwent stapedectomy . The control group was made up of patients with an inactive focus of the disease ; they underwent stapedectomy without administration of NaF. Results : The difference between the study groups in the degree of difficulty in extracting the footplate was not found to be statistically significant . Both groups had hearing gains in bone and air conduction . The level of posttreatment hearing gain in the group exposed to NaF was greater than that in the nonexposed group . Conclusions : Sodium fluoride administered to patients with mixed otosclerosis and an active focus of disease does not increase the difficulty of working with the footplate during stapedectomy , and it increases the hearing gain after the procedure The effect of sodium fluoride treatment in patients with otospongiosis has been evaluated in a prospect i ve clinical double-blind , placebo-controlled study of 95 patients . The results showed a statistically significant greater deterioration of hearing loss in the placebo group than in the group actively treated with 40 mg of sodium fluoride daily . These results support the view that sodium fluoride can change otospongiotic , active lesions to more dense , inactive otosclerotic lesions UNLABELLED Otospongiosis is a primary osteodystrophy of the otic capsule that affects genetically predisposed individuals and leads to a progressive hearing loss . AIM To evaluate the applicability of audiometric evaluation during drug treatment for otospongiosis . MATERIAL S AND METHODS A prospect i ve , r and omized , controlled , double-blind study involving 26 patients with clinical , audiometric and CT scan image of otosclerosis . Patients eligible for the study were divided into three groups ( A , B and C ) and received treatment with alendronate sodium ( B ) , sodium fluoride ( C ) and placebo ( A ) for 6 months . After this period they were su bmi tted to new tests . RESULTS There were not statistically significant differences between air and bone conduction ( gap ) . We also found no differences in the speech recognition threshold ( SRT ) and speech discrimination ( IRF ) between before and after treatment . CONCLUSION After six months of drug treatment the audiometric evaluation kept the same hearing thresholds , suggesting stabilization of the otospongiotic lesions 
    Output:
    
agent
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Objectives : We assessed the effect of using preoperative sodium fluoride ( NaF ) on the difficulty of working with the footplate during stapedectomy and its effect on the postsurgical hearing gain in patients with mixed otosclerosis ( ie , otosclerosis and /or otospongiosis ) . Methods : There were 2 groups of patients with mixed otosclerosis . The experimental group was made up of patients with an active focus of the disease ; they received NaF for 6 months and then underwent stapedectomy . The control group was made up of patients with an inactive focus of the disease ; they underwent stapedectomy without administration of NaF. Results : The difference between the study groups in the degree of difficulty in extracting the footplate was not found to be statistically significant . Both groups had hearing gains in bone and air conduction . The level of posttreatment hearing gain in the group exposed to NaF was greater than that in the nonexposed group . Conclusions : Sodium fluoride administered to patients with mixed otosclerosis and an active focus of disease does not increase the difficulty of working with the footplate during stapedectomy , and it increases the hearing gain after the procedure The effect of sodium fluoride treatment in patients with otospongiosis has been evaluated in a prospect i ve clinical double-blind , placebo-controlled study of 95 patients . The results showed a statistically significant greater deterioration of hearing loss in the placebo group than in the group actively treated with 40 mg of sodium fluoride daily . These results support the view that sodium fluoride can change otospongiotic , active lesions to more dense , inactive otosclerotic lesions UNLABELLED Otospongiosis is a primary osteodystrophy of the otic capsule that affects genetically predisposed individuals and leads to a progressive hearing loss . AIM To evaluate the applicability of audiometric evaluation during drug treatment for otospongiosis . MATERIAL S AND METHODS A prospect i ve , r and omized , controlled , double-blind study involving 26 patients with clinical , audiometric and CT scan image of otosclerosis . Patients eligible for the study were divided into three groups ( A , B and C ) and received treatment with alendronate sodium ( B ) , sodium fluoride ( C ) and placebo ( A ) for 6 months . After this period they were su bmi tted to new tests . RESULTS There were not statistically significant differences between air and bone conduction ( gap ) . We also found no differences in the speech recognition threshold ( SRT ) and speech discrimination ( IRF ) between before and after treatment . CONCLUSION After six months of drug treatment the audiometric evaluation kept the same hearing thresholds , suggesting stabilization of the otospongiotic lesions 
    Output:
    