human
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Objective The objective was to evaluate the effect of a clinic-based intervention program on mammography use by inner-city women . Design A r and omized controlled trial employing firm system methodology was conducted . Setting The study setting was a general internal medicine clinic in the university-affiliated county hospital serving metropolitan Seattle . Participants Women aged 50 to 74 years with at least one routine clinic appointment ( when they were due for mammography ) during the study period were enrolled in the trial ( n=314 ) . Interventions The intervention program emphasized nursing involvement and included physician education , provider prompts , use of audiovisual an printed patient education material s , transportation assistance in the form of bus passes , preppointment telephone or postcard reminders , and rescheduling assistance . Control firm women received usual care . Measurement and Main Results Mammography completion within 8 weeks of clinic visits was significantly higher among intervention ( 49 % ) than control ( 22 % ) firm women ( p<.001 ) . These effects persisted after adjustment for potential confounding by age , race , medical insurance coverage , and previous mammography experience at the hospital ( odds ratio 3.5 ; 95 % confidence interval 1.9 , 6.5 ) . The intervention effect was modified by type of insurance coverage as well as prior mammography history . Process evaluation indicated that bus passes and rescheduling efforts did not contribute to the observed increases in screening participation . Conclusions A clinic-based program incorporating physician education , provider prompts , patient education material s , and appointment reminders and emphasizing nursing involvement can facilitate adherence to breast cancer screening guidelines among inner-city women Two theory-based programs to increase mammography screening rates among asymptomatic women were implemented and evaluated in the community . One program ( E ) was based on the Health Belief Model ( HBM ) ; the second program ( EP ) added exercises adapted from the social psychology of compliance . Program impact on screening among 295 primarily Caucasian , middle-class women was evaluated against untreated controls ( C ) over a 6-month period . Both programs led to increases in HBM components ( Perceived Susceptibility , and Perceived Benefits ) and Intentions to obtain a mammogram . Screening rates 2 to 3 times higher were observed in the EP and E over C conditions ; EP and E did not differ . A mediational model of compliance illustrated the interplay of HBM components in the compliance process In an academic general medicine clinic , we performed a r and omized , controlled trial to compare ( 1 ) the effects of supplying monthly feedback reports of compliance with preventive care protocol s by 135 internal medicine house staff with ( 2 ) the effects of specific reminders given to them at the time of patient visits . The protocol s were r and omly divided into two groups , A and B , and half the house staff were given feedback for Group A and half for Group B. Thus , each group served as a control for the other . Each feedback group was also r and omly assigned to receive reminders for either Group A or B protocol s. House staff receiving feedback more often complied with fecal occult blood testing , mammography , pneumococcal vaccination , use of metronidazole , and combined Group A and B protocol s than did controls ( P < 0.01 ) . There was also significantly more compliance with the same protocol s by house staff receiving reminders , but the increase for fecal occult blood testing , pneumococcal vaccination , and combined Group A protocol s was twice that seen in physicians given feedback alone . In addition , reminders alone increased compliance with oral calcium supplementation . Overall compliance with the preventive care protocol s was low : 10 - 15 % in physicians receiving neither feedback nor reminders , increasing to 15 - 30 % in those receiving reminders . Physician compliance with suggested preventive care protocol s can be increased by both delayed feedback and immediate reminders , but reminders have a greater effect BACKGROUND Although rates of mammography screening among women in the general population have been increasing they still fall short of national goals . This study evaluated the effects on rates of participation in mammography screening of obtaining risk factor information and providing general or personalized risk information through direct mailed correspondence . METHODS Women enrollees in a health maintenance organization ( N = 2,076 ) , age 50 and above , were r and omized to one of the following four groups : ( a ) no risk factor question naire + generic invitation , ( b ) no risk factor question naire + general risk invitation , ( c ) risk factor question naire + general risk invitation , and ( d ) risk factor question naire + personal risk invitation . Computerized visit records were monitored for 12 months following a mailed invitation to assess whether a mammogram had been obtained . RESULTS Overall participation was 37.5 % and the rate of participation did not differ significantly across groups ( P = 0.26 ) . Participation was related to age ( P < 0.02 ) , with rates highest for women ages 60 - 69 years ( 42.7 % ) compared with those for women ages 50 - 59 ( 35.5 % ) and those age 70 + ( 33.7 % ) . Among women with a family history of breast cancer , the personalized risk invitation was associated with significantly higher participation compared with general risk invitation ( 66.7 versus 42.9 % , respectively ; P < 0.003 ) . CONCLUSIONS Women with a family history of breast cancer are more likely to obtain a mammogram if that fact is reinforced as a risk factor . Research on environmental barriers to mammography screening may suggest alternative strategies for increasing participation OBJECTIVE --To discover whether systematic methods of call and recall are more effective than a non- systematic method and to see which of the two systematic methods was more effective . DESIGN -- Prospect i ve r and omised controlled trial over a year . SETTING --One group general practice . PATIENTS --416 Women over 35 eligible for a smear test who had never had a cervical smear test or in whom a smear test was overdue ( previous test more than five years before ) . INTERVENTIONS --One group received written invitations to have a smear taken . The second group had their notes tagged so that the doctor would remind them ( when they attended for another reason ) to have a smear test . No special intervention was made in the third group . MAIN OUTCOME MEASURE -- Performance of a cervical smear test during the year of the study . RESULTS --32 % ( 45/140 ) of the screened group , 27 % ( 39/142 ) of the tagged group , and 15 % ( 20/134 ) of the control group had a smear test during the year . The percentage of women having a smear test in the screened group was not significantly different from that in the tagged group , but the percentages in the two groups were significantly different from that in the control group . Whether a woman had had a previous smear test significantly affected the uptake of the invitation to have a smear test independently of the method of invitation . CONCLUSIONS --The systematic methods of call and recall were more effective than a non- systematic method . There was no significant difference between the two systematic methods ( sending letters or tagging the notes ) at one year BACKGROUND Although tests for occult blood in the feces are widely used to screen for colorectal cancers , there is no conclusive evidence that they reduce mortality from this cause . We evaluated a fecal occult-blood test  in a r and omized trial and documented its effectiveness . METHODS We r and omly assigned 46,551 participants 50 to 80 years of age to screening for colorectal cancer once a year , to  screening every two years , or to a control group .  Participants who were screened su bmi tted six guaiac-impregnated paper slides with two smears from each of three consecutive stools . About 83 percent of the slides were rehydrated . Participants who tested positive underwent a diagnostic evaluation that included colonoscopy .  Vital status was ascertained for all study participants during 13 years of follow-up . A committee determined causes of death . A single pathologist determined the stage of each tissue specimen . Differences in mortality from colorectal cancer , the primary study end point , were monitored with the sequential log-rank statistic . RESULTS The 13-year cumulative mortality per 1000 from colorectal cancer was 5.88 in the annually screened group ( 95 percent confidence interval , 4.61 to 7.15 ) , 8.33 in the biennially screened group ( 95 percent confidence interval , 6.82 to 9.84 ) , and 8.83 in the control group ( 95 percent confidence interval , 7.26 to 10.40 ) . The rate in the annually screened group , but not in the biennially screened group , was significantly lower than that in the control group . Reduced mortality in the annually screened group was accompanied by improved survival in those with colorectal cancer and a shift to detection at an earlier stage of cancer . CONCLUSIONS Annual fecal occult-blood testing with rehydration of the sample s decreased the 13-year cumulative mortality from colorectal cancer by 33 percent Objectives – Firstly , to determine whether the acceptance rate of the second invitation for breast screening ( sent to women who have failed to attend after the first invitation ) might be increased by an accompanying letter from a general practitioner ( GP letter ) . Secondly , to identify the additional costs of sending such a letter . Methods – 465 women registered with four practice s in a single health centre were recruited into a r and omised controlled trial in which the intervention was the inclusion of a st and ard , photocopied letter signed by the non-attender 's doctor with the second invitation to attend for breast screening . The control group received only the st and ard invitation from the breast screening centre . The costs associated with the intervention were assessed from data supplied by the breast screening centre , supplemented by direct observation of the preparation of second invitations and semistructured interviews with the staff taking part . Results - The attendance rate of the test group one month after the second invitation for screening was significantly higher than that of the control group ( 21 % v 10 % , P<0.01 ) . The average cost of a GP letter included with the invitation was 1.1 pence and the marginal cost for each extra attender was 9.6 pence . No non-monetary costs were identified . Conclusions – The inclusion of a GP letter appeared to be effective and feasible in increasing the attendance rate to the second invitation . This intervention should be tested in other screening groups to confirm the effectiveness of a GP letter and its cost effectiveness Patient compliance in returning fecal-hemoccult card packets has been studied in recent years but no specific interventions have been shown consistently to improve the return rate . It was wondered whether removing a small financial barrier for indigent patients would positively affect compliance . Therefore , the effect of prepaid postage on the rate of return was studied . Pre-prepared packets containing hemoccult cards with return envelopes were distributed in a r and omized fashion to indigent and private insurance patients in outpatient clinics . On half of the return envelopes return postage was applied . The main outcome measure was the rate of return of stamped and unstamped packets  stratified between indigent and private insurance patients . The overall rates of return were 117 of 159 ( 74 % ) for the stamped packets and 102 of 166 ( 61 % ) for unstamped packets ( p < 0.02 ) . After stratification , in the indigent patients ( n = 177 ) , 73 of 95 ( 77 % ) stamped packets were returned compared to 46 of 82 ( 56 % ) unstamped packets ( p < 0.006 ) . In the private insurance patients ( N = 148 ) , 44 of 64 stamped packets ( 69 % ) and 52 of 84 unstamped packets ( 62 % ) were returned ( p > 0.10 ) . Removing even small financial barriers ( eg , providing a postage stamp ) can enhance compliance for indigent patients The results of the Swedish two-county trial of mammographic screening for breast cancer are presented , up date d to December 31 , 1990 , which is an average of 10.8 years follow-up per person . The main result of the trial in terms of breast cancer mortality remained the same : compared with the control group , the group invited to screening had a relative breast cancer mortality of 0.70 ( P = 0.0002 ) with 95 % confidence interval ( 0.58 , 0.85 ) . Analysis of survival showed that relative to the control group , the cancers detected at prevalence screen , incidence screens , and in the interval between screens had a good prognosis , whereas cancers detected in those who had refused screening had a very poor prognosis . When adjusted for tumor size , lymph node status , and tumor grade ( differentiation ) , the better survival associated with incidence screen and interval detection was largely accounted for , indicating that the benefit of incidence screening is largely achieved through the effect of screening on the three prognostic variables , notably size of the tumor . Results indicate that to achieve a substantial mortality reduction , 50 % of screen-detected invasive cancers should be less than 15 mm in diameter , at least 30 % of screen-detected grade 3 tumors should be less than 15 mm , and at least 70 % of screen-detected tumors should not have lymph node metastases . The percentage of grade 3 tumors of a given size should be the same in screen-detected cancers as in clinical ly detected , and breast cancer prevalence at first screen should be at least three times the expected incidence rate in the absence of screening . This should be achieved without the recall rate for further examination exceeding 9 % , and procedures including further imaging techniques and fine needle aspiration or core biopsy should be used before resorting to surgical biopsy . These aims can be achieved in specialist screening centers if particular attention is paid to re sources for screening and diagnostic evaluation , specialist training of clinical and technolog 
    Output:
    
agent
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Objective The objective was to evaluate the effect of a clinic-based intervention program on mammography use by inner-city women . Design A r and omized controlled trial employing firm system methodology was conducted . Setting The study setting was a general internal medicine clinic in the university-affiliated county hospital serving metropolitan Seattle . Participants Women aged 50 to 74 years with at least one routine clinic appointment ( when they were due for mammography ) during the study period were enrolled in the trial ( n=314 ) . Interventions The intervention program emphasized nursing involvement and included physician education , provider prompts , use of audiovisual an printed patient education material s , transportation assistance in the form of bus passes , preppointment telephone or postcard reminders , and rescheduling assistance . Control firm women received usual care . Measurement and Main Results Mammography completion within 8 weeks of clinic visits was significantly higher among intervention ( 49 % ) than control ( 22 % ) firm women ( p<.001 ) . These effects persisted after adjustment for potential confounding by age , race , medical insurance coverage , and previous mammography experience at the hospital ( odds ratio 3.5 ; 95 % confidence interval 1.9 , 6.5 ) . The intervention effect was modified by type of insurance coverage as well as prior mammography history . Process evaluation indicated that bus passes and rescheduling efforts did not contribute to the observed increases in screening participation . Conclusions A clinic-based program incorporating physician education , provider prompts , patient education material s , and appointment reminders and emphasizing nursing involvement can facilitate adherence to breast cancer screening guidelines among inner-city women Two theory-based programs to increase mammography screening rates among asymptomatic women were implemented and evaluated in the community . One program ( E ) was based on the Health Belief Model ( HBM ) ; the second program ( EP ) added exercises adapted from the social psychology of compliance . Program impact on screening among 295 primarily Caucasian , middle-class women was evaluated against untreated controls ( C ) over a 6-month period . Both programs led to increases in HBM components ( Perceived Susceptibility , and Perceived Benefits ) and Intentions to obtain a mammogram . Screening rates 2 to 3 times higher were observed in the EP and E over C conditions ; EP and E did not differ . A mediational model of compliance illustrated the interplay of HBM components in the compliance process In an academic general medicine clinic , we performed a r and omized , controlled trial to compare ( 1 ) the effects of supplying monthly feedback reports of compliance with preventive care protocol s by 135 internal medicine house staff with ( 2 ) the effects of specific reminders given to them at the time of patient visits . The protocol s were r and omly divided into two groups , A and B , and half the house staff were given feedback for Group A and half for Group B. Thus , each group served as a control for the other . Each feedback group was also r and omly assigned to receive reminders for either Group A or B protocol s. House staff receiving feedback more often complied with fecal occult blood testing , mammography , pneumococcal vaccination , use of metronidazole , and combined Group A and B protocol s than did controls ( P < 0.01 ) . There was also significantly more compliance with the same protocol s by house staff receiving reminders , but the increase for fecal occult blood testing , pneumococcal vaccination , and combined Group A protocol s was twice that seen in physicians given feedback alone . In addition , reminders alone increased compliance with oral calcium supplementation . Overall compliance with the preventive care protocol s was low : 10 - 15 % in physicians receiving neither feedback nor reminders , increasing to 15 - 30 % in those receiving reminders . Physician compliance with suggested preventive care protocol s can be increased by both delayed feedback and immediate reminders , but reminders have a greater effect BACKGROUND Although rates of mammography screening among women in the general population have been increasing they still fall short of national goals . This study evaluated the effects on rates of participation in mammography screening of obtaining risk factor information and providing general or personalized risk information through direct mailed correspondence . METHODS Women enrollees in a health maintenance organization ( N = 2,076 ) , age 50 and above , were r and omized to one of the following four groups : ( a ) no risk factor question naire + generic invitation , ( b ) no risk factor question naire + general risk invitation , ( c ) risk factor question naire + general risk invitation , and ( d ) risk factor question naire + personal risk invitation . Computerized visit records were monitored for 12 months following a mailed invitation to assess whether a mammogram had been obtained . RESULTS Overall participation was 37.5 % and the rate of participation did not differ significantly across groups ( P = 0.26 ) . Participation was related to age ( P < 0.02 ) , with rates highest for women ages 60 - 69 years ( 42.7 % ) compared with those for women ages 50 - 59 ( 35.5 % ) and those age 70 + ( 33.7 % ) . Among women with a family history of breast cancer , the personalized risk invitation was associated with significantly higher participation compared with general risk invitation ( 66.7 versus 42.9 % , respectively ; P < 0.003 ) . CONCLUSIONS Women with a family history of breast cancer are more likely to obtain a mammogram if that fact is reinforced as a risk factor . Research on environmental barriers to mammography screening may suggest alternative strategies for increasing participation OBJECTIVE --To discover whether systematic methods of call and recall are more effective than a non- systematic method and to see which of the two systematic methods was more effective . DESIGN -- Prospect i ve r and omised controlled trial over a year . SETTING --One group general practice . PATIENTS --416 Women over 35 eligible for a smear test who had never had a cervical smear test or in whom a smear test was overdue ( previous test more than five years before ) . INTERVENTIONS --One group received written invitations to have a smear taken . The second group had their notes tagged so that the doctor would remind them ( when they attended for another reason ) to have a smear test . No special intervention was made in the third group . MAIN OUTCOME MEASURE -- Performance of a cervical smear test during the year of the study . RESULTS --32 % ( 45/140 ) of the screened group , 27 % ( 39/142 ) of the tagged group , and 15 % ( 20/134 ) of the control group had a smear test during the year . The percentage of women having a smear test in the screened group was not significantly different from that in the tagged group , but the percentages in the two groups were significantly different from that in the control group . Whether a woman had had a previous smear test significantly affected the uptake of the invitation to have a smear test independently of the method of invitation . CONCLUSIONS --The systematic methods of call and recall were more effective than a non- systematic method . There was no significant difference between the two systematic methods ( sending letters or tagging the notes ) at one year BACKGROUND Although tests for occult blood in the feces are widely used to screen for colorectal cancers , there is no conclusive evidence that they reduce mortality from this cause . We evaluated a fecal occult-blood test  in a r and omized trial and documented its effectiveness . METHODS We r and omly assigned 46,551 participants 50 to 80 years of age to screening for colorectal cancer once a year , to  screening every two years , or to a control group .  Participants who were screened su bmi tted six guaiac-impregnated paper slides with two smears from each of three consecutive stools . About 83 percent of the slides were rehydrated . Participants who tested positive underwent a diagnostic evaluation that included colonoscopy .  Vital status was ascertained for all study participants during 13 years of follow-up . A committee determined causes of death . A single pathologist determined the stage of each tissue specimen . Differences in mortality from colorectal cancer , the primary study end point , were monitored with the sequential log-rank statistic . RESULTS The 13-year cumulative mortality per 1000 from colorectal cancer was 5.88 in the annually screened group ( 95 percent confidence interval , 4.61 to 7.15 ) , 8.33 in the biennially screened group ( 95 percent confidence interval , 6.82 to 9.84 ) , and 8.83 in the control group ( 95 percent confidence interval , 7.26 to 10.40 ) . The rate in the annually screened group , but not in the biennially screened group , was significantly lower than that in the control group . Reduced mortality in the annually screened group was accompanied by improved survival in those with colorectal cancer and a shift to detection at an earlier stage of cancer . CONCLUSIONS Annual fecal occult-blood testing with rehydration of the sample s decreased the 13-year cumulative mortality from colorectal cancer by 33 percent Objectives – Firstly , to determine whether the acceptance rate of the second invitation for breast screening ( sent to women who have failed to attend after the first invitation ) might be increased by an accompanying letter from a general practitioner ( GP letter ) . Secondly , to identify the additional costs of sending such a letter . Methods – 465 women registered with four practice s in a single health centre were recruited into a r and omised controlled trial in which the intervention was the inclusion of a st and ard , photocopied letter signed by the non-attender 's doctor with the second invitation to attend for breast screening . The control group received only the st and ard invitation from the breast screening centre . The costs associated with the intervention were assessed from data supplied by the breast screening centre , supplemented by direct observation of the preparation of second invitations and semistructured interviews with the staff taking part . Results - The attendance rate of the test group one month after the second invitation for screening was significantly higher than that of the control group ( 21 % v 10 % , P<0.01 ) . The average cost of a GP letter included with the invitation was 1.1 pence and the marginal cost for each extra attender was 9.6 pence . No non-monetary costs were identified . Conclusions – The inclusion of a GP letter appeared to be effective and feasible in increasing the attendance rate to the second invitation . This intervention should be tested in other screening groups to confirm the effectiveness of a GP letter and its cost effectiveness Patient compliance in returning fecal-hemoccult card packets has been studied in recent years but no specific interventions have been shown consistently to improve the return rate . It was wondered whether removing a small financial barrier for indigent patients would positively affect compliance . Therefore , the effect of prepaid postage on the rate of return was studied . Pre-prepared packets containing hemoccult cards with return envelopes were distributed in a r and omized fashion to indigent and private insurance patients in outpatient clinics . On half of the return envelopes return postage was applied . The main outcome measure was the rate of return of stamped and unstamped packets  stratified between indigent and private insurance patients . The overall rates of return were 117 of 159 ( 74 % ) for the stamped packets and 102 of 166 ( 61 % ) for unstamped packets ( p < 0.02 ) . After stratification , in the indigent patients ( n = 177 ) , 73 of 95 ( 77 % ) stamped packets were returned compared to 46 of 82 ( 56 % ) unstamped packets ( p < 0.006 ) . In the private insurance patients ( N = 148 ) , 44 of 64 stamped packets ( 69 % ) and 52 of 84 unstamped packets ( 62 % ) were returned ( p > 0.10 ) . Removing even small financial barriers ( eg , providing a postage stamp ) can enhance compliance for indigent patients The results of the Swedish two-county trial of mammographic screening for breast cancer are presented , up date d to December 31 , 1990 , which is an average of 10.8 years follow-up per person . The main result of the trial in terms of breast cancer mortality remained the same : compared with the control group , the group invited to screening had a relative breast cancer mortality of 0.70 ( P = 0.0002 ) with 95 % confidence interval ( 0.58 , 0.85 ) . Analysis of survival showed that relative to the control group , the cancers detected at prevalence screen , incidence screens , and in the interval between screens had a good prognosis , whereas cancers detected in those who had refused screening had a very poor prognosis . When adjusted for tumor size , lymph node status , and tumor grade ( differentiation ) , the better survival associated with incidence screen and interval detection was largely accounted for , indicating that the benefit of incidence screening is largely achieved through the effect of screening on the three prognostic variables , notably size of the tumor . Results indicate that to achieve a substantial mortality reduction , 50 % of screen-detected invasive cancers should be less than 15 mm in diameter , at least 30 % of screen-detected grade 3 tumors should be less than 15 mm , and at least 70 % of screen-detected tumors should not have lymph node metastases . The percentage of grade 3 tumors of a given size should be the same in screen-detected cancers as in clinical ly detected , and breast cancer prevalence at first screen should be at least three times the expected incidence rate in the absence of screening . This should be achieved without the recall rate for further examination exceeding 9 % , and procedures including further imaging techniques and fine needle aspiration or core biopsy should be used before resorting to surgical biopsy . These aims can be achieved in specialist screening centers if particular attention is paid to re sources for screening and diagnostic evaluation , specialist training of clinical and technolog 
    Output:
    