human
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Objective : To examine the language development at corrected age 4 years of a regionally representative cohort of children born very preterm ( VPT ) . Of particular interest was the identification of biological and socioenvironmental risk and protective factors that influence  VPT children 's early language development . Method : Data were collected as part of a prospect i ve longitudinal study of 110 VPT ( VPT : ≤33 weeks gestation ) and 113 full-term children ( full term : 37–41 weeks gestation ) born in Canterbury , New Zeal and from 1998 to 2000 . At corrected age 4 years , all children were assessed with the preschool version of the Clinical Evaluation of Language Fundamentals . Extensive information was also collected about children 's family social background , perinatal health , childrearing environment , education/intervention exposures , and neurodevelopmental progress from birth to age 4 . Results : At the age of 4 years , VPT children were characterized by poorer receptive and expressive language development than full-term children . These differences persisted after exclusion of children with neurosensory impairment as well as statistical adjustment for the effects of social risk . Within the VPT group , the key predictors of children 's overall language development were family social risk at birth ( p = .05 ) , severity of white matter abnormalities on neonatal magnetic resonance imaging ( p = .49 ) , observed parent-child synchrony ( p = .001 ) , and concurrent child cognitive ability ( p = .001 ) . Together , these factors accounted for 45 % of the variance in children 's total Clinical Evaluation of Language Fundamentals — Preschool scores . Conclusion : By preschool age , children born VPT  show early emerging mild to moderate language delays that are likely to affect their school success and longer-term developmental progress . Findings highlight the importance of potentially modifiable factors such as early brain injury and parenting quality in predicting the language outcomes of children born VPT OBJECTIVES : The goal was to examine whether indomethacin use , gender , neonatal , and sociodemographic factors predict patterns of receptive language development from 3 to 12 years of age in preterm children . METHODS : A total of 355 children born in 1989–1992 with birth weights of 600 to 1250 g were evaluated at 3 , 4.5 , 6 , 8 , and 12 years with the Peabody Picture Vocabulary Test-Revised  . Hierarchical growth modeling was used to explore differences in language trajectories . RESULTS : From 3 to 12 years , preterm children displayed catch-up gains on the Peabody Picture Vocabulary Test-Revised . Preterm children started with an average st and ardized score of 84.1 at 3 years and gained 1.2 points per year across the age period studied . Growth-curve analyses of Peabody Picture Vocabulary Test-Revised raw scores revealed an indomethacin-gender effect on initial scores at 3 years , with preterm boys assigned r and omly to receive indomethacin scoring , on average , 4.2 points higher than placebo-treated boys . However , the velocity of receptive vocabulary development from 3 to 12 years did not differ for the treatment groups . Children with severe brain injury demonstrated slower gains in skills over time , compared with those who did not suffer severe brain injury . Significant differences in language trajectories were predicted by maternal education and minority status . CONCLUSION : Although indomethacin yielded an initial benefit for preterm boys , this intervention did not alter the developmental trajectory of receptive language scores . Severe brain injury leads to long-term sequelae in language development , whereas a socioeconomically advantaged environment supports better language development among preterm children Background : Major neurological h and icaps and neuropsychological disturbances are more common in ex-preterm children than their counterparts born at term . Objective : To establish in a prospect i ve study whether a characteristic neuropsychological profile exists in ex-preterm children who do not exhibit neurodevelopmental deficits on routine clinical examination . Methods : Thirty intellectually normal children born preterm ( 30–34 weeks gestation ) without major neurological disabilities and a control group of term children matched for age , sex , and parental educational and occupational status were assessed at 3–4 years of age to obtain a complete neuropsychological profile . Intellectual ability , language comprehension and expression , perceptual and visual motor function , working memory , and attention and behavioural problems were investigated . Results : Even in the absence of major neurological signs , children born preterm achieved lower mean scores than controls on the Stanford-Binet intelligence scale ( 110.8 v 121 , p<0.001 ) , visual perception test ( 33.8 v 42.7 , p<0.001 ) , visual motor integration test ( 42.6 v 47.4 , p = 0.049 ) , memory for location test ( 8.4 v 9.5 , p = 0.007 ) , sustained attention test ( 41.6 v 51.5 , p = 0.009 ) , and the picture vocabulary test ( 33.3 v 44.7 , p = 0.021 ) . Conclusions : Neuropsychological abnormalities can be detected early in childhood in apparently normal ex-preterm children and are consistent with a growing body of evidence that prematurity may be associated with long term neuropsychological morbidity in childhood and adolescence 
    Output:
    
agent
RESULTS : Preterm-born children scored significantly lower compared with term-born children on simple ( d = –0.45 [ 95 % CI : –0.59 to –0.30 ] ; P < .001 ) and on complex ( d = –0.62 [ 95 % CI : –0.82 to –0.43 ] ; P < .001 ) language function tests , even in the absence of major disabilities and independent of social economic status .
: While growing up , preterm-born children have increasing difficulties with complex language function
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Objective : To examine the language development at corrected age 4 years of a regionally representative cohort of children born very preterm ( VPT ) . Of particular interest was the identification of biological and socioenvironmental risk and protective factors that influence  VPT children 's early language development . Method : Data were collected as part of a prospect i ve longitudinal study of 110 VPT ( VPT : ≤33 weeks gestation ) and 113 full-term children ( full term : 37–41 weeks gestation ) born in Canterbury , New Zeal and from 1998 to 2000 . At corrected age 4 years , all children were assessed with the preschool version of the Clinical Evaluation of Language Fundamentals . Extensive information was also collected about children 's family social background , perinatal health , childrearing environment , education/intervention exposures , and neurodevelopmental progress from birth to age 4 . Results : At the age of 4 years , VPT children were characterized by poorer receptive and expressive language development than full-term children . These differences persisted after exclusion of children with neurosensory impairment as well as statistical adjustment for the effects of social risk . Within the VPT group , the key predictors of children 's overall language development were family social risk at birth ( p = .05 ) , severity of white matter abnormalities on neonatal magnetic resonance imaging ( p = .49 ) , observed parent-child synchrony ( p = .001 ) , and concurrent child cognitive ability ( p = .001 ) . Together , these factors accounted for 45 % of the variance in children 's total Clinical Evaluation of Language Fundamentals — Preschool scores . Conclusion : By preschool age , children born VPT  show early emerging mild to moderate language delays that are likely to affect their school success and longer-term developmental progress . Findings highlight the importance of potentially modifiable factors such as early brain injury and parenting quality in predicting the language outcomes of children born VPT OBJECTIVES : The goal was to examine whether indomethacin use , gender , neonatal , and sociodemographic factors predict patterns of receptive language development from 3 to 12 years of age in preterm children . METHODS : A total of 355 children born in 1989–1992 with birth weights of 600 to 1250 g were evaluated at 3 , 4.5 , 6 , 8 , and 12 years with the Peabody Picture Vocabulary Test-Revised  . Hierarchical growth modeling was used to explore differences in language trajectories . RESULTS : From 3 to 12 years , preterm children displayed catch-up gains on the Peabody Picture Vocabulary Test-Revised . Preterm children started with an average st and ardized score of 84.1 at 3 years and gained 1.2 points per year across the age period studied . Growth-curve analyses of Peabody Picture Vocabulary Test-Revised raw scores revealed an indomethacin-gender effect on initial scores at 3 years , with preterm boys assigned r and omly to receive indomethacin scoring , on average , 4.2 points higher than placebo-treated boys . However , the velocity of receptive vocabulary development from 3 to 12 years did not differ for the treatment groups . Children with severe brain injury demonstrated slower gains in skills over time , compared with those who did not suffer severe brain injury . Significant differences in language trajectories were predicted by maternal education and minority status . CONCLUSION : Although indomethacin yielded an initial benefit for preterm boys , this intervention did not alter the developmental trajectory of receptive language scores . Severe brain injury leads to long-term sequelae in language development , whereas a socioeconomically advantaged environment supports better language development among preterm children Background : Major neurological h and icaps and neuropsychological disturbances are more common in ex-preterm children than their counterparts born at term . Objective : To establish in a prospect i ve study whether a characteristic neuropsychological profile exists in ex-preterm children who do not exhibit neurodevelopmental deficits on routine clinical examination . Methods : Thirty intellectually normal children born preterm ( 30–34 weeks gestation ) without major neurological disabilities and a control group of term children matched for age , sex , and parental educational and occupational status were assessed at 3–4 years of age to obtain a complete neuropsychological profile . Intellectual ability , language comprehension and expression , perceptual and visual motor function , working memory , and attention and behavioural problems were investigated . Results : Even in the absence of major neurological signs , children born preterm achieved lower mean scores than controls on the Stanford-Binet intelligence scale ( 110.8 v 121 , p<0.001 ) , visual perception test ( 33.8 v 42.7 , p<0.001 ) , visual motor integration test ( 42.6 v 47.4 , p = 0.049 ) , memory for location test ( 8.4 v 9.5 , p = 0.007 ) , sustained attention test ( 41.6 v 51.5 , p = 0.009 ) , and the picture vocabulary test ( 33.3 v 44.7 , p = 0.021 ) . Conclusions : Neuropsychological abnormalities can be detected early in childhood in apparently normal ex-preterm children and are consistent with a growing body of evidence that prematurity may be associated with long term neuropsychological morbidity in childhood and adolescence 
    Output:
    