human
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: BACKGROUND Current ACSM guidelines recommend that adults should exercise for 20 - 60 min on 3 - 5 days.week(-1 ) ( M.L. Pollock , et al. , The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness , and flexibility in healthy adults . Medicine and Science in Sports and Exercise , 30 ( 6 ) ( 1998 ) 975 - 991 . ) . For individuals constrained by a busy lifestyle , an exercise prescription that delivers benefits with the minimum investment of time is attractive . The purpose of the present study , therefore , was to examine the effect of instructing sedentary individuals to undertake 20 min of brisk walking , in two different patterns , 3 days per week , on fitness and other cardiovascular disease ( CVD ) risk factors . METHODS Forty-eight subjects ( 31 women ) mean ( + /-SD ) age 45.7 + /- 9.4 year were r and omly assigned to either one 20-min walk ( single bout ) , two 10-min walks ( accumulated bouts ) 3 days week(-1 ) for 12-week , or no training ( control ) . Oxygen consumption ( VO2 ) , heart rate ( HR ) , and ratings of perceived exertion ( RPE ) were measured during a 4-stage treadmill test at pre- and post-intervention . Body composition , resting blood pressure and fasting lipoproteins were also assessed . Thirty-two subjects completed the study . RESULTS There was a significant difference between single-bout and accumulated-bout walkers in the reduction of HR at stages 2 and 3 of the treadmill test from pre- to post-intervention ( P < 0.05 ) . There were no differences between groups for changes in VO2 or RPE from pre- to post-intervention . There were also no changes in body mass , adiposity , blood pressure , waist and hip circumferences , or lipid/lipoproteins . CONCLUSION Brisk walking for 20 min on 3 days of the week fails to alter cardiovascular disease risk factors in previously sedentary adults Abstract This study examined the effects of one single bout daily versus triple bouts of resistance exercise for 12 weeks on muscular strength and anaerobic performance of the upper body . Twenty young male adults ( age : 22.0 ± 1.0 years , bench press : 44.0 ± 10.3 kg ) were r and omly assigned to a single bout ( SB ) or triple bouts ( TB ) of resistance exercise group . Maximal strength and anaerobic performance of the upper body using the bench press ( one-repetition maximum ) and the modified 30 s Wingate test were determined before and after the intervention . Additionally , changes in lactate levels before and after the Wingate test were measured . Although the SB and TB groups showed a significant increase in maximal strength ( post-intervention , SB : 67.2 ± 9.2 and TB : 67.6 ± 7.6 kg , respectively ) compared with the values at pre-intervention ( SB : 44.6 ± 11.4 and TB : 43.9 ± 8.7 kg , respectively ) , there was no significant difference for this variable between the two groups post-intervention ( p > 0.05 ) . The anaerobic performance of the upper body in the SB and TB groups also displayed improvements without significant difference between the two groups after the completion of different training regimes . On the basis of the same training volume , multiple bouts of resistance training showed similar improvements in maximal strength and anaerobic performance to one bout of resistance training in young adult men without prior experience in resistance The aim of this study was to determine whether accumulated short bouts of exercise can achieve the same cardiovascular benefits as a single long bout of exercise in sedentary male Japanese workers and to compare the programs ’ relative effects on oxidative stress . Twenty-three sedentary male workers were r and omly assigned into 2 different exercise programs : a Long-bout group , which performed a single period of continuous exercise ( Long-bout group : 30 min × 1 ) 3 d per week , and a Short-bouts group , which performed 3 short bouts of exercise ( Short-bouts group : 10 min × 3 ) 3 d per week . Cardiovascular risk factors , including the plasma thiobarbituric acid-reactive substances ( TBARS ) level , were examined at baseline and after both 10 and 20 wk . In the Long-bout group , waist circumference and maximum oxygen uptake ( VO2max ) significantly improved after 20 wk . The Short-bouts group demonstrated significant increases in VO2max after 10 weeks and in HDL-C after 20 wk . Plasma TBARS significantly decreased after 20 weeks in the Long-bout group and tended to decrease ( but not significantly ) in the Short-bouts group . These results indicate that accumulated short bouts of exercise are an effective option , especially for busy workers , for incorporating exercise into one ’s lifestyle BACKGROUND AND PURPOSE Menopause may induce a phase of rapid decreases in bone mineral density , aerobic fitness , muscle strength , and balance , especially in sedentary women . The purpose of this study was to examine the effects and feasibility of an exercise program of 1 or 2 bouts of walking and resistance training on lower-extremity muscle strength ( the force-generating capacity of muscle ) , balance , and walking performance in women who recently went through menopause . SUBJECTS AND METHODS The subjects were 134 women who recently went through menopause . The study was a 15-week , r and omized , controlled trial with continuous and fractionated exercise groups . The outcomes assessed were lower-extremity muscle strength , balance , and walking time over 2 km . Feasibility was assessed by question naires , interviews , and training logs . RESULTS One hundred twenty-eight women completed the study .  Adherence to the study protocol was 92 % . Both continuous and fractionated exercise groups improved equally in lower-extremity muscle strength and walking time but not in balance . Almost 70 % of the subjects considered the program to be feasible . Two daily walking sessions caused fewer lower-extremity problems than did continuous walking . DISCUSSION AND CONCLUSION Brisk walking combined with moderate resistance training is feasible and effective . Fractionating the walking into 2 daily sessions is more feasible than continuous walking Objective : The specific aim of this study was to determine if three 10 minute bouts of exercise per day ( 3 × 10 ) and two 15 minute bouts per day ( 2 × 15 ) were as effective as one 30 minute bout per day ( 1 × 30 ) for improving VO2 max and weight loss . Methods : Overweight , female college students ( body mass index ≥28 kg/m2 ) were recruited and assessed at baseline and post-treatment for aerobic fitness ( Astr and maximal cycle test ) , weight , skinfold thickness ( 7-site ) , and circumference measures ( 4-site ) . Following measurement of  resting energy expenditure ( REE ) , subjects were asked to follow a self-monitored calorie restricted diet ( 80 % of REE ) for the twelve week duration of the study and were assigned ( non-r and om ) to one of four treatment groups : 1 ) a nonexercising control group ( control , n = 8) , 2 ) a 30 minutes continuous exercise group ( 1 × 30 , n = 12 ) , 3 ) a 30 minutes accumulated exercise group ( 2 × 15 , n = 10 ) and 4 ) a second 30 minutes accumulated exercise group ( 3 × 10 , n = 8) . The exercising subjects participated in aerobic exercise training at 75 % of heart rate reserve three to five days per week with all exercise monitored . Results : VO2 max increased significantly while weight , body mass index , sum of skinfolds , and sum of circumferences decreased significantly from baseline to post-treatment in the 1 × 30 , 2 × 15 and the 3 × 10 groups , but not in the control group . A tertiary finding was that exercise participation did not differ among the exercising groups with regard to the average number of days per week . Conclusions : These results support the hypothesis that exercise accumulated in several short bouts has similar effects as one continuous bout with regard to aerobic fitness and weight loss during caloric restriction in overweight , young women PURPOSE To compare the effects of different patterns of regular brisk walking on fitness , risk factors for cardiovascular disease , and psychological well-being in previously sedentary adults . METHODS Twenty-one subjects ( 14 women ) , aged 44.5 + /- 6.1 yr ( mean + /- SD ) were r and omly assigned to two different , 6-wk programs of brisk walking in a cross-over design , with an interval of 2 wk . One program comprised one 30-min walk per day , 5 d.wk(-1 ) ( long bout ) and the other three 10-min walks per day , also 5 d.wk(-1 ) ( short bouts ) . All walking was at 70 - 80 % of predicted maximal heart rate . Maximal oxygen uptake ( (.)VO(2max ) ) , body composition , resting arterial blood pressure , fasting plasma lipoprotein variables , and psychological parameters were assessed before and after each program . RESULTS Overall , subjects completed 88.2 + /- 1.1 % and 91.3 + /- 4.1 % of prescribed total walking time in the short- and long-bout programs , respectively . Both programs increased plasma concentrations of high-density lipoprotein cholesterol , and decreased concentrations of triacylglycerol and total cholesterol ( all < 0.05 ) . There were no changes in body mass , but the sum of four skinfolds , waist circumference , and hip circumference were decreased after both walking programs ( all P<0.05 ) . Predicted (.)VO(2max ) increased with both programs ( P<0.05 ) , but this increase was greater with the program based on short bouts ( P<0.05 ) . Both walking patterns result ed in similar decreases in tension/anxiety ( P<0.05 ) . CONCLUSION These findings suggest that three short bouts ( 10 min ) of brisk walking accumulated throughout the day are at least as effective as one continuous bout of equal total duration in reducing cardiovascular risk and improving aspects of mood in previously sedentary individuals BACKGROUND AND PURPOSE The purpose s of this study were : ( 1 ) to assess the effectiveness of a 16-week progressive program of home-based , videotape-based , low-impact aerobic exercise on physical function and signs and symptoms of fibromyalgia in previously sedentary women aged 20 to 55 years and ( 2 ) to compare the effects of 1 long exercise bout versus 2 short exercise bouts per training day ( fractionation ) on physical function , signs and symptoms of fibromyalgia , and exercise adherence . SUBJECTS One hundred forty-three sedentary women were r and omly assigned to 1 of 3 groups : a group who trained using a long bout of exercise ( LBE group , n=51 ) , a group who trained using short bouts of exercise ( SBE group , n=56 ) , and a group who performed no exercise ( NE group , n=36 ) . METHODS The SBE group exercised twice daily , and the LBE group worked out once daily . Both groups progressed in total daily training duration from 10 to 30 minutes , 3 to 5 times a week , for 16 weeks . Physical and psychological well-being , symptoms , and self-efficacy were evaluated using a multivariate analysis of variance . RESULTS Dropout rates for the NE , SBE , and LBE groups were 14 % , 38 % , and 29 % , respectively . The NE group differed from the LBE group in disease severity , self-efficacy , and psychological well-being ( midtest , efficacy analysis ) and from the SBE group in disease severity and self-efficacy ( posttest , efficacy analysis ) . Exercise adherence was greater for the LBE group than for the SBE group between weeks 5 and 8 of the training program . No other differences between exercise groups were found . DISCUSSION AND CONCLUSION Progressive , home-based , low-impact aerobics improved physical function and fibromyalgia symptoms minimally in participants who completed at least two thirds of the recommended exercise . Fractionation of exercise training provided no advantage in terms of exercise adherence , improvements in fibromyalgia symptoms or physical function . High attrition rates and problems with exercise adherence were experienced in both exercise groups This study sought to determine whether a 12-week intermittent ( INT ; 2 3 15 min·d−1 ) exercise program yielded similar improvements in cardiovascular health and fitness , compared with a traditional 12-week , 30-minute continuous ( CON ; 1 X 30 min·d−1 ) exercise program . A second purpose was to determine the effects of switching exercise programs and continuing training for an additional 12 weeks . Twenty women and 17 men , ( age 48.8 ± 9.0 years ) were divided r and omly into 2 groups : INT ( n = 20 ) and CON ( n = 17 ) . Aerobic exercise was performed 4 d·wk−1 for 12 weeks . Subjects then crossed over to the opposite training program for an additional 12 weeks of training . Subjects exercised incrementally for weeks 1–4 and training was conducted at 70–80 % heart rate reserve for weeks 5–24 . Both groups showed comparable exercise adherence , completing 96.6 ± 12.2 % ( CON ) and 96.3 % ± 17.7 % ( INT ) of the prescribed exercise time . The INT walked at a lower percentage of & OV0312;O2max , maximum heart rate , systolic blood pressure , and diastolic blood pressure ( p < 0.05 ) . Maximal oxygen consumption increased by 4.5 % 
    Output:
    
agent
There is no difference between continuous and accumulated patterns of exercise in terms of effects on fitness , blood pressure , lipids , insulin and glucose .
There is some evidence from a small number of studies that changes in body mass and LDL cholesterol are more favourable following the accumulated condition .
Collectively our findings suggest that adults are likely to accrue similar health benefits from exercising in a single bout or accumulating activity from shorter bouts throughout the day .
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: BACKGROUND Current ACSM guidelines recommend that adults should exercise for 20 - 60 min on 3 - 5 days.week(-1 ) ( M.L. Pollock , et al. , The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness , and flexibility in healthy adults . Medicine and Science in Sports and Exercise , 30 ( 6 ) ( 1998 ) 975 - 991 . ) . For individuals constrained by a busy lifestyle , an exercise prescription that delivers benefits with the minimum investment of time is attractive . The purpose of the present study , therefore , was to examine the effect of instructing sedentary individuals to undertake 20 min of brisk walking , in two different patterns , 3 days per week , on fitness and other cardiovascular disease ( CVD ) risk factors . METHODS Forty-eight subjects ( 31 women ) mean ( + /-SD ) age 45.7 + /- 9.4 year were r and omly assigned to either one 20-min walk ( single bout ) , two 10-min walks ( accumulated bouts ) 3 days week(-1 ) for 12-week , or no training ( control ) . Oxygen consumption ( VO2 ) , heart rate ( HR ) , and ratings of perceived exertion ( RPE ) were measured during a 4-stage treadmill test at pre- and post-intervention . Body composition , resting blood pressure and fasting lipoproteins were also assessed . Thirty-two subjects completed the study . RESULTS There was a significant difference between single-bout and accumulated-bout walkers in the reduction of HR at stages 2 and 3 of the treadmill test from pre- to post-intervention ( P < 0.05 ) . There were no differences between groups for changes in VO2 or RPE from pre- to post-intervention . There were also no changes in body mass , adiposity , blood pressure , waist and hip circumferences , or lipid/lipoproteins . CONCLUSION Brisk walking for 20 min on 3 days of the week fails to alter cardiovascular disease risk factors in previously sedentary adults Abstract This study examined the effects of one single bout daily versus triple bouts of resistance exercise for 12 weeks on muscular strength and anaerobic performance of the upper body . Twenty young male adults ( age : 22.0 ± 1.0 years , bench press : 44.0 ± 10.3 kg ) were r and omly assigned to a single bout ( SB ) or triple bouts ( TB ) of resistance exercise group . Maximal strength and anaerobic performance of the upper body using the bench press ( one-repetition maximum ) and the modified 30 s Wingate test were determined before and after the intervention . Additionally , changes in lactate levels before and after the Wingate test were measured . Although the SB and TB groups showed a significant increase in maximal strength ( post-intervention , SB : 67.2 ± 9.2 and TB : 67.6 ± 7.6 kg , respectively ) compared with the values at pre-intervention ( SB : 44.6 ± 11.4 and TB : 43.9 ± 8.7 kg , respectively ) , there was no significant difference for this variable between the two groups post-intervention ( p > 0.05 ) . The anaerobic performance of the upper body in the SB and TB groups also displayed improvements without significant difference between the two groups after the completion of different training regimes . On the basis of the same training volume , multiple bouts of resistance training showed similar improvements in maximal strength and anaerobic performance to one bout of resistance training in young adult men without prior experience in resistance The aim of this study was to determine whether accumulated short bouts of exercise can achieve the same cardiovascular benefits as a single long bout of exercise in sedentary male Japanese workers and to compare the programs ’ relative effects on oxidative stress . Twenty-three sedentary male workers were r and omly assigned into 2 different exercise programs : a Long-bout group , which performed a single period of continuous exercise ( Long-bout group : 30 min × 1 ) 3 d per week , and a Short-bouts group , which performed 3 short bouts of exercise ( Short-bouts group : 10 min × 3 ) 3 d per week . Cardiovascular risk factors , including the plasma thiobarbituric acid-reactive substances ( TBARS ) level , were examined at baseline and after both 10 and 20 wk . In the Long-bout group , waist circumference and maximum oxygen uptake ( VO2max ) significantly improved after 20 wk . The Short-bouts group demonstrated significant increases in VO2max after 10 weeks and in HDL-C after 20 wk . Plasma TBARS significantly decreased after 20 weeks in the Long-bout group and tended to decrease ( but not significantly ) in the Short-bouts group . These results indicate that accumulated short bouts of exercise are an effective option , especially for busy workers , for incorporating exercise into one ’s lifestyle BACKGROUND AND PURPOSE Menopause may induce a phase of rapid decreases in bone mineral density , aerobic fitness , muscle strength , and balance , especially in sedentary women . The purpose of this study was to examine the effects and feasibility of an exercise program of 1 or 2 bouts of walking and resistance training on lower-extremity muscle strength ( the force-generating capacity of muscle ) , balance , and walking performance in women who recently went through menopause . SUBJECTS AND METHODS The subjects were 134 women who recently went through menopause . The study was a 15-week , r and omized , controlled trial with continuous and fractionated exercise groups . The outcomes assessed were lower-extremity muscle strength , balance , and walking time over 2 km . Feasibility was assessed by question naires , interviews , and training logs . RESULTS One hundred twenty-eight women completed the study .  Adherence to the study protocol was 92 % . Both continuous and fractionated exercise groups improved equally in lower-extremity muscle strength and walking time but not in balance . Almost 70 % of the subjects considered the program to be feasible . Two daily walking sessions caused fewer lower-extremity problems than did continuous walking . DISCUSSION AND CONCLUSION Brisk walking combined with moderate resistance training is feasible and effective . Fractionating the walking into 2 daily sessions is more feasible than continuous walking Objective : The specific aim of this study was to determine if three 10 minute bouts of exercise per day ( 3 × 10 ) and two 15 minute bouts per day ( 2 × 15 ) were as effective as one 30 minute bout per day ( 1 × 30 ) for improving VO2 max and weight loss . Methods : Overweight , female college students ( body mass index ≥28 kg/m2 ) were recruited and assessed at baseline and post-treatment for aerobic fitness ( Astr and maximal cycle test ) , weight , skinfold thickness ( 7-site ) , and circumference measures ( 4-site ) . Following measurement of  resting energy expenditure ( REE ) , subjects were asked to follow a self-monitored calorie restricted diet ( 80 % of REE ) for the twelve week duration of the study and were assigned ( non-r and om ) to one of four treatment groups : 1 ) a nonexercising control group ( control , n = 8) , 2 ) a 30 minutes continuous exercise group ( 1 × 30 , n = 12 ) , 3 ) a 30 minutes accumulated exercise group ( 2 × 15 , n = 10 ) and 4 ) a second 30 minutes accumulated exercise group ( 3 × 10 , n = 8) . The exercising subjects participated in aerobic exercise training at 75 % of heart rate reserve three to five days per week with all exercise monitored . Results : VO2 max increased significantly while weight , body mass index , sum of skinfolds , and sum of circumferences decreased significantly from baseline to post-treatment in the 1 × 30 , 2 × 15 and the 3 × 10 groups , but not in the control group . A tertiary finding was that exercise participation did not differ among the exercising groups with regard to the average number of days per week . Conclusions : These results support the hypothesis that exercise accumulated in several short bouts has similar effects as one continuous bout with regard to aerobic fitness and weight loss during caloric restriction in overweight , young women PURPOSE To compare the effects of different patterns of regular brisk walking on fitness , risk factors for cardiovascular disease , and psychological well-being in previously sedentary adults . METHODS Twenty-one subjects ( 14 women ) , aged 44.5 + /- 6.1 yr ( mean + /- SD ) were r and omly assigned to two different , 6-wk programs of brisk walking in a cross-over design , with an interval of 2 wk . One program comprised one 30-min walk per day , 5 d.wk(-1 ) ( long bout ) and the other three 10-min walks per day , also 5 d.wk(-1 ) ( short bouts ) . All walking was at 70 - 80 % of predicted maximal heart rate . Maximal oxygen uptake ( (.)VO(2max ) ) , body composition , resting arterial blood pressure , fasting plasma lipoprotein variables , and psychological parameters were assessed before and after each program . RESULTS Overall , subjects completed 88.2 + /- 1.1 % and 91.3 + /- 4.1 % of prescribed total walking time in the short- and long-bout programs , respectively . Both programs increased plasma concentrations of high-density lipoprotein cholesterol , and decreased concentrations of triacylglycerol and total cholesterol ( all < 0.05 ) . There were no changes in body mass , but the sum of four skinfolds , waist circumference , and hip circumference were decreased after both walking programs ( all P<0.05 ) . Predicted (.)VO(2max ) increased with both programs ( P<0.05 ) , but this increase was greater with the program based on short bouts ( P<0.05 ) . Both walking patterns result ed in similar decreases in tension/anxiety ( P<0.05 ) . CONCLUSION These findings suggest that three short bouts ( 10 min ) of brisk walking accumulated throughout the day are at least as effective as one continuous bout of equal total duration in reducing cardiovascular risk and improving aspects of mood in previously sedentary individuals BACKGROUND AND PURPOSE The purpose s of this study were : ( 1 ) to assess the effectiveness of a 16-week progressive program of home-based , videotape-based , low-impact aerobic exercise on physical function and signs and symptoms of fibromyalgia in previously sedentary women aged 20 to 55 years and ( 2 ) to compare the effects of 1 long exercise bout versus 2 short exercise bouts per training day ( fractionation ) on physical function , signs and symptoms of fibromyalgia , and exercise adherence . SUBJECTS One hundred forty-three sedentary women were r and omly assigned to 1 of 3 groups : a group who trained using a long bout of exercise ( LBE group , n=51 ) , a group who trained using short bouts of exercise ( SBE group , n=56 ) , and a group who performed no exercise ( NE group , n=36 ) . METHODS The SBE group exercised twice daily , and the LBE group worked out once daily . Both groups progressed in total daily training duration from 10 to 30 minutes , 3 to 5 times a week , for 16 weeks . Physical and psychological well-being , symptoms , and self-efficacy were evaluated using a multivariate analysis of variance . RESULTS Dropout rates for the NE , SBE , and LBE groups were 14 % , 38 % , and 29 % , respectively . The NE group differed from the LBE group in disease severity , self-efficacy , and psychological well-being ( midtest , efficacy analysis ) and from the SBE group in disease severity and self-efficacy ( posttest , efficacy analysis ) . Exercise adherence was greater for the LBE group than for the SBE group between weeks 5 and 8 of the training program . No other differences between exercise groups were found . DISCUSSION AND CONCLUSION Progressive , home-based , low-impact aerobics improved physical function and fibromyalgia symptoms minimally in participants who completed at least two thirds of the recommended exercise . Fractionation of exercise training provided no advantage in terms of exercise adherence , improvements in fibromyalgia symptoms or physical function . High attrition rates and problems with exercise adherence were experienced in both exercise groups This study sought to determine whether a 12-week intermittent ( INT ; 2 3 15 min·d−1 ) exercise program yielded similar improvements in cardiovascular health and fitness , compared with a traditional 12-week , 30-minute continuous ( CON ; 1 X 30 min·d−1 ) exercise program . A second purpose was to determine the effects of switching exercise programs and continuing training for an additional 12 weeks . Twenty women and 17 men , ( age 48.8 ± 9.0 years ) were divided r and omly into 2 groups : INT ( n = 20 ) and CON ( n = 17 ) . Aerobic exercise was performed 4 d·wk−1 for 12 weeks . Subjects then crossed over to the opposite training program for an additional 12 weeks of training . Subjects exercised incrementally for weeks 1–4 and training was conducted at 70–80 % heart rate reserve for weeks 5–24 . Both groups showed comparable exercise adherence , completing 96.6 ± 12.2 % ( CON ) and 96.3 % ± 17.7 % ( INT ) of the prescribed exercise time . The INT walked at a lower percentage of & OV0312;O2max , maximum heart rate , systolic blood pressure , and diastolic blood pressure ( p < 0.05 ) . Maximal oxygen consumption increased by 4.5 % 
    Output:
    