human
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background and Purpose — The role of physical activity , especially that of occupational and commuting physical activity , in the prediction of stroke risk is not properly established . We assessed the relationship of different types of physical activity with total and type-specific stroke risk . Methods — We prospect ively followed 47 721 Finnish subjects 25 to 64 years of age without a history of coronary heart disease , stroke , or cancer at baseline .  Hazard ratios ( HRs ) for incident stroke were estimated for different levels of leisure time , occupational , and commuting physical activity . Results — During a mean follow-up of 19.0 years , 2863 incident stroke events were ascertained . The multivariate-adjusted ( age , sex , area , study year , body mass index , systolic blood pressure , cholesterol , education , smoking , alcohol consumption , diabetes , and other 2 types of physical activity ) HRs associated with low , moderate , and high leisure time physical activity were 1.00 , 0.86 , and 0.74 ( Ptrend<0.001 ) for total stroke , 1.00 , 0.87 , and 0.46 ( Ptrend=0.011 ) for subarachnoid hemorrhage , 1.00 , 0.77 , and 0.63 ( Ptrend=0.024 ) for intracerebral hemorrhage , and 1.00 , 0.87 , and 0.80 ( Ptrend=0.001 ) for ischemic stroke , respectively . The multivariate-adjusted HRs associated with none , 1 to 29 , and ≥30 minutes of active commuting were 1.00 , 0.92 , and 0.89 ( Ptrend=0.043 ) for total stroke , and 1.00 , 0.93 , and 0.86 ( Ptrend=0.028 ) for ischemic stroke , respectively . Occupational activity had a modest association with ischemic stroke in the multivariate analysis ( Ptrend=0.046 ) . Conclusion — A high level of leisure time physical activity  reduces the risk of all subtypes of stroke . Daily active commuting also reduces the risk of ischemic stroke In the 1970s Archie Cochrane noted that many healthcare procedures and forms of organisation lacked evidence of effectiveness and efficiency , and argued for improved methods of evaluation , moving from clinical opinion and observation to r and omised controlled trials ( RCTs ) . His arguments gradually became accepted in medicine , but there has been considerable resistance among policymakers and research ers to their application to social and public health interventions . This essay argues that opposition to RCTs in public health is often based on a false distinction between healthcare and community setting s , and sometimes on a misunderst and ing of the principles of RCTs in health care . It suggests that just as in medicine , good intentions and received wisdom are not a sufficient basis for making public policy and allocating public funds for social or health improvement Study objective : To determine if a self help intervention , delivered via written interactive material s ( the “ Walk in to Work Out ” pack ) , could increase  active commuting behaviour ( walking and cycling ) . Design : R and omised controlled trial . The intervention group received the “ Walk in to Work Out ” pack , which contained written interactive material s based on the transtheoretical model of behaviour change , local information about distances and routes , and safety information . The control group received the pack six months later . Focus groups were also conducted after six months . Setting : Three workplaces in the city of Glasgow , Scotl and , UK . Participants : 295 employees who had been identified as thinking about , or doing some irregular , walking or cycling to work . Main results : The intervention group was almost twice as likely to increase walking to work as the control group at six months ( odds ratio of 1.93 , 95 % confidence intervals 1.06 to 3.52 ) . The intervention was not successful at increasing cycling . There were no distance travelled to work , gender , or age influences on the results . Twenty five per cent ( 95 % confidence intervals 17 % to 32 % ) of the intervention group , who received the pack at baseline , were regularly actively commuting at the 12 month follow up . Conclusion : The “ Walk in to Work Out ” pack was successful in increasing walking but not cycling . The environment for cycling must be improved before cycling will become a popular option Reports of studies relating physical activity to stroke and cancer sub-types indicate inconsistent findings . Some are hampered by low statistical power , owing to a low number of events , and a failure to adjust for potential confounding variables . The purpose of this study was to relate physical activity to 12 mortality endpoints in a prospect i ve cohort study of 11,663 men aged 40–64 years who responded to an enquiry about travel activity during a baseline medical examination conducted between 1967 and 1969 . During 25 years of follow-up there were 4672  deaths .  Travel activity  was inversely related to mortality attributable to all-causes , coronary heart disease , respiratory disease and lung cancer , whereas the association with stroke was positive . There was evidence for attenuation of some of these associations on adjustment for potentially confounding variables . Our simplistic measure of physical activity may , in part , explain the weak associations seen There is good evidence that physical activity reduces the risk for cardiovascular disease ( 1 - 6 ) , possibly in part by lowering blood pressure ( 7 ) . Although mild or moderate physical activity , such as brisk walking , is a recommended part of the treatment protocol for persons with hypertension ( 8 , 9 ) , it is not known whether mild physical activity , especially walking , reduces the risk for hypertension . With few exceptions , epidemiologic studies of physical activity and hypertension have been cross-sectional rather than prospect i ve . Physical activity was inversely related to blood pressure in cross-sectional and controlled studies ( 7 ) , and in two prospect i ve studies ( 10 , 11 ) , vigorous exercise was inversely related to the subsequent risk for hypertension . Physicians in Japan usually advise their patients to walk to work as often as they can , and indeed , for middle-aged working Japanese men , the journey to and from work seems to be the main source of exercise . We prospect ively examined the relation of mild physical activity , especially walking to work , and leisure-time physical activity to the risk for hypertension during 6 to 16 years of observation . Methods The Osaka Health Survey The Osaka Health Survey is an ongoing cohort study of risk factors for chronic diseases , including hypertension and diabetes . Study participants are male employees of a gas company in Osaka , Japan . Japanese law requires all employers to conduct annual health screenings for all employees . For the purpose s of the Osaka Health Survey , in addition to these annual screenings , all employees 35 years of age or older undergo more detailed biennial clinical examinations and complete question naires on health-related behaviors , including exercise . Study Sample Between 1981 and 1990 , 7979 Japanese men 35 to 63 years of age at entry who had sedentary occupations were enrolled in the study . We excluded 1875 men because they had physician-diagnosed hypertension , borderline hypertension ( systolic blood pressure 140 and < 160 mm Hg , diastolic blood pressure 90 and < 95 mm Hg , or both in men without a history of hypertension ) , diabetes , or impaired glucose tolerance ( fasting plasma glucose level 6.1 mmol/L [ 110 mg/dL ] and < 7.8 mmol/L [ < 140 mg/dL ] in men with no history of diabetes ) at entry . The study sample ultimately consisted of 6104 men . Data Collection and Measurements The biennial clinical examination consisted of a medical history ; a physical examination ; blood pressure measurement ; anthropometric measurements ; measurement of the fasting plasma glucose level ; and surveys of health-related behaviors , such as physical activity , smoking , and daily alcohol consumption . Trained nurses took all measurements . Participants were asked to fast for 12 hours and to avoid smoking and heavy physical activity for more than 2 hours before the examination . After a 5-minute rest in a quiet room , a st and ard mercury sphygmomanometer was used to measure systolic and diastolic blood pressures in the right arm while the participant was seated . Pressure was measured twice , at an interval of a few minutes . Anthropometric measurements included height and body weight , which were measured while the participant was wearing light clothing without shoes . Body mass index was calculated as the weight in kilograms divided by the height in meters squared . The question naire completed by each participant elicited information on leisure-time physical activity , the duration of the walk to work , the nature of the participant 's occupation , and the level of activity involved . Leisure-time physical activity was defined as physical activity unrelated to the participant 's work . Questions about leisure-time physical activity were as follows : Do you engage in any regular physical exercise , such as jogging , bicycling , swimming , and tennis , long enough to work up a sweat ( lasting 30 minutes or more ) ? If yes , how many times per week ? What exercise is this ? The questions about regular physical exercise have been vali date d as a measure of physical exercise ( 12 - 15 ) . In the analysis , participants were classified as engaging in regular physical exercise at least once per week or less than once per week . They were also classified into one of three categories of exercise frequency : 0 ( less than once per week ) , once per week , or two or more times per week . The question about the duration of the walk to work was How long does it take you to walk to this office ? Occupational activity was scored as 1 if the participant 's work was mostly sedentary and 2 if he worked outside or if the job required a lot of lifting and walking . In the present study , we excluded all participants who reported a score of 2 for their occupational activities . Questions about alcohol intake included items about the type of alcoholic beverage , the weekly frequency of alcohol consumption , and the usual amount consumed daily . Alcohol intake was converted to total alcohol consumption ( in milliliters of ethanol per day ) by using st and ard Japanese tables . Current and past smoking habits were classified according to the type and quantity of cigarettes smoked daily . Participants were classified as current smokers , past smokers , or nonsmokers . Hypertension was also diagnosed during the biennial study clinical examinations . All participants underwent medical screening by a physician at least once annually , and hypertension was also diagnosed by the physicians . Hypertension was defined by using World Health Organization criteria as physician-diagnosed hypertension ( systolic blood pressure 160 mm Hg , diastolic blood pressure 95 mm Hg , or both ) or use of antihypertensive medication ( 16 ) . Statistical Analysis Age-adjusted mean values and relevant population characteristics were computed for the duration of the walk to work by using analysis of covariance for continuous variables and the direct method for categorical variables . For each participant , person-years of follow-up were counted from the date at study entry to the date of diagnosis of hypertension or 1 April 1997 , whichever came first . The rate of follow-up was 94 % of the total potential person-years of follow-up . Multivariate Cox proportional-hazards regression models were used to evaluate the simultaneous effects of the duration of the walk to work , the frequency of leisure-time physical activity , age , body mass index  , daily alcohol consumption , smoking status , and fasting plasma glucose level . Baseline systolic and diastolic blood pressure were not included in our primary analyses because they could presumably be in the causal pathway between the exposures ( such as physical activity , age , body mass index , and alcohol consumption ) and risk for hypertension . However , we included systolic and diastolic blood pressure in further models to assess the effect of physical activity on the risk for hypertension independent of their effects on systolic and diastolic blood pressure . The linear trends in risks were evaluated by entering indicators for each categorical level of exposure or by using the median value for each category . As a reference category , we used men with the lowest level of physical activity . To address the potential misclassification of leisure-time physical activity over time , additional analyses were performed on the basis of the data at both study entry ( 1981 to 1990 ) and the examination done 4 years after ( 1985 to 1994 ) each participant was enrolled . We also performed analyses that excluded participants who developed hypertension between study entry ( 1981 to 1990 ) and the third examination done 4 years later ( 1985 to 1994 ) . We calculated the 95 % CI for each relative risk ( 17 ) , and all P values are two-tailed . Statistical analyses were performed by using the SPSS 7.5J software package ( SPSS , Inc. , Chicago , Illinois ) . We estimated the number needed to walk , a value analogous to the number needed to treat . The number needed to treat for a given therapy is the reciprocal of the absolute risk reduction for that treatment ( 18 ) . A 95 % CI for the number needed to treat is obtained simply by taking reciprocals of the values defining the 95 % CI of the absolute risk reduction ( 19 ) . In our study , the number needed to walk was defined as the number of men who would have to adopt walking to avoid a single case of hypertension . The number needed to treat must always be based on an outcome for a specific period of time ( 20 ) ; thus , in estimating the number needed to walk , we chose an observation period of 10 years between study entry ( 1981 to 1986 ) and the examination done 10 years after ( 1991 to 1996 ) each participant was enrolled . Role of the Funding Source The funding agencies did not participate in the collection , analysis , or interpretation of data presented in this report or in the decision to su bmi t the manuscript for publication . Results Of the 6104 men eligible for this study between 1981 and 19 
    Output:
    
agent
Active travel may have positive effects on health outcomes , but there is little robust evidence to date of the effectiveness of active transport interventions for reducing obesity .
***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background and Purpose — The role of physical activity , especially that of occupational and commuting physical activity , in the prediction of stroke risk is not properly established . We assessed the relationship of different types of physical activity with total and type-specific stroke risk . Methods — We prospect ively followed 47 721 Finnish subjects 25 to 64 years of age without a history of coronary heart disease , stroke , or cancer at baseline .  Hazard ratios ( HRs ) for incident stroke were estimated for different levels of leisure time , occupational , and commuting physical activity . Results — During a mean follow-up of 19.0 years , 2863 incident stroke events were ascertained . The multivariate-adjusted ( age , sex , area , study year , body mass index , systolic blood pressure , cholesterol , education , smoking , alcohol consumption , diabetes , and other 2 types of physical activity ) HRs associated with low , moderate , and high leisure time physical activity were 1.00 , 0.86 , and 0.74 ( Ptrend<0.001 ) for total stroke , 1.00 , 0.87 , and 0.46 ( Ptrend=0.011 ) for subarachnoid hemorrhage , 1.00 , 0.77 , and 0.63 ( Ptrend=0.024 ) for intracerebral hemorrhage , and 1.00 , 0.87 , and 0.80 ( Ptrend=0.001 ) for ischemic stroke , respectively . The multivariate-adjusted HRs associated with none , 1 to 29 , and ≥30 minutes of active commuting were 1.00 , 0.92 , and 0.89 ( Ptrend=0.043 ) for total stroke , and 1.00 , 0.93 , and 0.86 ( Ptrend=0.028 ) for ischemic stroke , respectively . Occupational activity had a modest association with ischemic stroke in the multivariate analysis ( Ptrend=0.046 ) . Conclusion — A high level of leisure time physical activity  reduces the risk of all subtypes of stroke . Daily active commuting also reduces the risk of ischemic stroke In the 1970s Archie Cochrane noted that many healthcare procedures and forms of organisation lacked evidence of effectiveness and efficiency , and argued for improved methods of evaluation , moving from clinical opinion and observation to r and omised controlled trials ( RCTs ) . His arguments gradually became accepted in medicine , but there has been considerable resistance among policymakers and research ers to their application to social and public health interventions . This essay argues that opposition to RCTs in public health is often based on a false distinction between healthcare and community setting s , and sometimes on a misunderst and ing of the principles of RCTs in health care . It suggests that just as in medicine , good intentions and received wisdom are not a sufficient basis for making public policy and allocating public funds for social or health improvement Study objective : To determine if a self help intervention , delivered via written interactive material s ( the “ Walk in to Work Out ” pack ) , could increase  active commuting behaviour ( walking and cycling ) . Design : R and omised controlled trial . The intervention group received the “ Walk in to Work Out ” pack , which contained written interactive material s based on the transtheoretical model of behaviour change , local information about distances and routes , and safety information . The control group received the pack six months later . Focus groups were also conducted after six months . Setting : Three workplaces in the city of Glasgow , Scotl and , UK . Participants : 295 employees who had been identified as thinking about , or doing some irregular , walking or cycling to work . Main results : The intervention group was almost twice as likely to increase walking to work as the control group at six months ( odds ratio of 1.93 , 95 % confidence intervals 1.06 to 3.52 ) . The intervention was not successful at increasing cycling . There were no distance travelled to work , gender , or age influences on the results . Twenty five per cent ( 95 % confidence intervals 17 % to 32 % ) of the intervention group , who received the pack at baseline , were regularly actively commuting at the 12 month follow up . Conclusion : The “ Walk in to Work Out ” pack was successful in increasing walking but not cycling . The environment for cycling must be improved before cycling will become a popular option Reports of studies relating physical activity to stroke and cancer sub-types indicate inconsistent findings . Some are hampered by low statistical power , owing to a low number of events , and a failure to adjust for potential confounding variables . The purpose of this study was to relate physical activity to 12 mortality endpoints in a prospect i ve cohort study of 11,663 men aged 40–64 years who responded to an enquiry about travel activity during a baseline medical examination conducted between 1967 and 1969 . During 25 years of follow-up there were 4672  deaths .  Travel activity  was inversely related to mortality attributable to all-causes , coronary heart disease , respiratory disease and lung cancer , whereas the association with stroke was positive . There was evidence for attenuation of some of these associations on adjustment for potentially confounding variables . Our simplistic measure of physical activity may , in part , explain the weak associations seen There is good evidence that physical activity reduces the risk for cardiovascular disease ( 1 - 6 ) , possibly in part by lowering blood pressure ( 7 ) . Although mild or moderate physical activity , such as brisk walking , is a recommended part of the treatment protocol for persons with hypertension ( 8 , 9 ) , it is not known whether mild physical activity , especially walking , reduces the risk for hypertension . With few exceptions , epidemiologic studies of physical activity and hypertension have been cross-sectional rather than prospect i ve . Physical activity was inversely related to blood pressure in cross-sectional and controlled studies ( 7 ) , and in two prospect i ve studies ( 10 , 11 ) , vigorous exercise was inversely related to the subsequent risk for hypertension . Physicians in Japan usually advise their patients to walk to work as often as they can , and indeed , for middle-aged working Japanese men , the journey to and from work seems to be the main source of exercise . We prospect ively examined the relation of mild physical activity , especially walking to work , and leisure-time physical activity to the risk for hypertension during 6 to 16 years of observation . Methods The Osaka Health Survey The Osaka Health Survey is an ongoing cohort study of risk factors for chronic diseases , including hypertension and diabetes . Study participants are male employees of a gas company in Osaka , Japan . Japanese law requires all employers to conduct annual health screenings for all employees . For the purpose s of the Osaka Health Survey , in addition to these annual screenings , all employees 35 years of age or older undergo more detailed biennial clinical examinations and complete question naires on health-related behaviors , including exercise . Study Sample Between 1981 and 1990 , 7979 Japanese men 35 to 63 years of age at entry who had sedentary occupations were enrolled in the study . We excluded 1875 men because they had physician-diagnosed hypertension , borderline hypertension ( systolic blood pressure 140 and < 160 mm Hg , diastolic blood pressure 90 and < 95 mm Hg , or both in men without a history of hypertension ) , diabetes , or impaired glucose tolerance ( fasting plasma glucose level 6.1 mmol/L [ 110 mg/dL ] and < 7.8 mmol/L [ < 140 mg/dL ] in men with no history of diabetes ) at entry . The study sample ultimately consisted of 6104 men . Data Collection and Measurements The biennial clinical examination consisted of a medical history ; a physical examination ; blood pressure measurement ; anthropometric measurements ; measurement of the fasting plasma glucose level ; and surveys of health-related behaviors , such as physical activity , smoking , and daily alcohol consumption . Trained nurses took all measurements . Participants were asked to fast for 12 hours and to avoid smoking and heavy physical activity for more than 2 hours before the examination . After a 5-minute rest in a quiet room , a st and ard mercury sphygmomanometer was used to measure systolic and diastolic blood pressures in the right arm while the participant was seated . Pressure was measured twice , at an interval of a few minutes . Anthropometric measurements included height and body weight , which were measured while the participant was wearing light clothing without shoes . Body mass index was calculated as the weight in kilograms divided by the height in meters squared . The question naire completed by each participant elicited information on leisure-time physical activity , the duration of the walk to work , the nature of the participant 's occupation , and the level of activity involved . Leisure-time physical activity was defined as physical activity unrelated to the participant 's work . Questions about leisure-time physical activity were as follows : Do you engage in any regular physical exercise , such as jogging , bicycling , swimming , and tennis , long enough to work up a sweat ( lasting 30 minutes or more ) ? If yes , how many times per week ? What exercise is this ? The questions about regular physical exercise have been vali date d as a measure of physical exercise ( 12 - 15 ) . In the analysis , participants were classified as engaging in regular physical exercise at least once per week or less than once per week . They were also classified into one of three categories of exercise frequency : 0 ( less than once per week ) , once per week , or two or more times per week . The question about the duration of the walk to work was How long does it take you to walk to this office ? Occupational activity was scored as 1 if the participant 's work was mostly sedentary and 2 if he worked outside or if the job required a lot of lifting and walking . In the present study , we excluded all participants who reported a score of 2 for their occupational activities . Questions about alcohol intake included items about the type of alcoholic beverage , the weekly frequency of alcohol consumption , and the usual amount consumed daily . Alcohol intake was converted to total alcohol consumption ( in milliliters of ethanol per day ) by using st and ard Japanese tables . Current and past smoking habits were classified according to the type and quantity of cigarettes smoked daily . Participants were classified as current smokers , past smokers , or nonsmokers . Hypertension was also diagnosed during the biennial study clinical examinations . All participants underwent medical screening by a physician at least once annually , and hypertension was also diagnosed by the physicians . Hypertension was defined by using World Health Organization criteria as physician-diagnosed hypertension ( systolic blood pressure 160 mm Hg , diastolic blood pressure 95 mm Hg , or both ) or use of antihypertensive medication ( 16 ) . Statistical Analysis Age-adjusted mean values and relevant population characteristics were computed for the duration of the walk to work by using analysis of covariance for continuous variables and the direct method for categorical variables . For each participant , person-years of follow-up were counted from the date at study entry to the date of diagnosis of hypertension or 1 April 1997 , whichever came first . The rate of follow-up was 94 % of the total potential person-years of follow-up . Multivariate Cox proportional-hazards regression models were used to evaluate the simultaneous effects of the duration of the walk to work , the frequency of leisure-time physical activity , age , body mass index  , daily alcohol consumption , smoking status , and fasting plasma glucose level . Baseline systolic and diastolic blood pressure were not included in our primary analyses because they could presumably be in the causal pathway between the exposures ( such as physical activity , age , body mass index , and alcohol consumption ) and risk for hypertension . However , we included systolic and diastolic blood pressure in further models to assess the effect of physical activity on the risk for hypertension independent of their effects on systolic and diastolic blood pressure . The linear trends in risks were evaluated by entering indicators for each categorical level of exposure or by using the median value for each category . As a reference category , we used men with the lowest level of physical activity . To address the potential misclassification of leisure-time physical activity over time , additional analyses were performed on the basis of the data at both study entry ( 1981 to 1990 ) and the examination done 4 years after ( 1985 to 1994 ) each participant was enrolled . We also performed analyses that excluded participants who developed hypertension between study entry ( 1981 to 1990 ) and the third examination done 4 years later ( 1985 to 1994 ) . We calculated the 95 % CI for each relative risk ( 17 ) , and all P values are two-tailed . Statistical analyses were performed by using the SPSS 7.5J software package ( SPSS , Inc. , Chicago , Illinois ) . We estimated the number needed to walk , a value analogous to the number needed to treat . The number needed to treat for a given therapy is the reciprocal of the absolute risk reduction for that treatment ( 18 ) . A 95 % CI for the number needed to treat is obtained simply by taking reciprocals of the values defining the 95 % CI of the absolute risk reduction ( 19 ) . In our study , the number needed to walk was defined as the number of men who would have to adopt walking to avoid a single case of hypertension . The number needed to treat must always be based on an outcome for a specific period of time ( 20 ) ; thus , in estimating the number needed to walk , we chose an observation period of 10 years between study entry ( 1981 to 1986 ) and the examination done 10 years after ( 1991 to 1996 ) each participant was enrolled . Role of the Funding Source The funding agencies did not participate in the collection , analysis , or interpretation of data presented in this report or in the decision to su bmi t the manuscript for publication . Results Of the 6104 men eligible for this study between 1981 and 19 
    Output:
    