***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Local treatment of burn injuries with conventional anti-infective preparations does not provide the moist environment that promotes fast wound healing . In a r and omized controlled trial the effects of liposome polyvinyl-pyrrolidone-iodine ( PVP-I ) hydrogel , a novel formulation of PVP-I in a liposome hydrogel with high water-binding capacity , were investigated in 43 patients with partial-thickness burn wounds in an intraindividual comparison with a conventional silver-sulfadiazine cream .  Treatment with liposome PVP-I hydrogel result ed in significantly faster complete healing of the burn wounds compared with silver-sulfadiazine cream ( 9.9 ± 4.5 days versus 11.3 ± 4.9 ; P < 0.015 ) . The cosmetic result ( smoothness , elasticity , appearance ) was rated as excellent for 37.0 % of study wounds with liposome PVP-I hydrogel compared with 13.0 % of wounds treated with silver-sulfadiazine cream . Local tolerability was good ; h and ling and change of dressing were rated as easy . Local treatment with liposome PVP-I hydrogel thus provides fast wound healing with a favorable cosmetic result St and ard treatment for extensive partial-thickness burns in the United States and in much of the world involves the application of topical antimicrobial agents and repetitive wound débridements and dressing changes . We evaluated a new biologic wound covering , TransCyte ( Advanced Tissue Sciences , La Jolla , Calif , formerly marketed as Dermagraft-Transitional Covering ) , for the treatment of partial-thickness burns . This material is composed of human newborn fibroblasts which are then cultured on the nylon mesh of Biobrane ( Dow B. Hickam , Inc , Sugarl and , Tex ) ; the thin silicone membrane bonded to the mesh provides a moisture vapor barrier for the wound . A prospect i ve , r and omized , comparison study of silver sulfadiazine and TransCyte was performed with the use of paired wound sites on 14 patients . Wounds treated with TransCyte  healed more quickly ( mean 11.14 days to 90 % epithelialization vs 18.14 days , P = .002 ) . A noncomparison evaluation was then done for an additional 18 patients , and it confirmed excellent wound healing and an absence of infections . There were no infections in the 32 wound sites treated with TransCyte . In the first study group , late wound evaluations ( 3 , 6 , and 12 months postburn ) were performed with use of the Vancouver Scar Scale . The results indicated that wound sites treated with TransCyte healed with less hypertrophic scarring than sites treated with silver sulfadiazine ( P < .001 at 3 and 6 months , P = .006 at 12 months ) Histological and clinical studies of wound healing have been made on comparable fresh partial thickness burns with honey dressing or silver sulfadiazine ( SSD ) in two groups of 25 r and omly allocated patients . Of the wounds treated with honey 84 per cent showed satisfactory epithelialization by the 7th day , and in 100 per cent of the patients by the 21st day . In wounds treated with silver sulfadiazine , epithelialization occurred by the 7th day in 72 per cent of the patients and in 84 per cent of patients by 21 days . Histological evidence of reparative activity was seen in 80 per cent of wounds treated with the honey dressing by the 7th day with minimal inflammation . Fifty two per cent of the silver sulfadiazine treated wounds showed reparative activity with inflammatory changes by the 7th day . Reparative activity reached 100 per cent by 21 days with the honey dressing and 84 per cent with SSD . Thus in honey dressed wounds , early subsidence of acute inflammatory changes , better control of infection and quicker wound healing was observed while in the SSD treated wounds sustained inflammatory reaction was noted even on epithelialization To compare the effect of honey dressing and silver-sulfadiazene ( SSD ) dressing on wound healing in burn patients . Patients ( n=78 ) of both sexes , with age group between 10 and 50 years and with first and second degree of burn of less than 50 % of TBSA ( Total body surface area ) were included in the study , over a period of 2 years ( 2006 - 08 ) . After stabilization , patients were r and omly attributed into two groups : ‘ honey group ’ and ‘ SSD group ’ . Time elapsed since burn was recorded . After washing with normal saline , undiluted pure honey was applied over the wounds of patients in the honey group ( n=37 ) and SSD cream over the wounds of patients in SSD group ( n=41 ) , everyday . Wound was dressed with sterile gauze , cotton pads and b and aged . Status of the wound was assessed every third and seventh day and on the day of completion of study . Patients were followed up every fortnight till epithelialization . The bacteriological examination of the wound was done every seventh day . The mean age for case ( honey group ) and control ( SSD group ) was 34.5 years and 28.5 years , respectively .  Wound swab culture was positive in 29 out of 36 patients who came within 8 hours of burn and in all patients who came after 24 hours . The average duration of healing in patients treated with honey and SSD dressing at any time of admission was 18.16 and 32.68 days , respectively . Wound of all those patients ( 100 % ) who reported within 1 hour became sterile with  honey  dressing in less than 7 days while none with SSD . All of the wounds became sterile in less than 21 days with honey , while tthis was so in only 36.5 % with SSD treated wounds . The honey group included 33 patients reported within 24 hour of injury , and 26 out of them had complete outcome at 2 months of follow-up , while numbers for the SSD group were 32 and 12 . Complete outcome for any admission point of time after 2 months was noted in 81 % and 37 % of patients in the honey group and the SSD group . Honey dressing  improves wound healing , makes the wound sterile in lesser time , has a better outcome in terms of prevention of hypertrophic scarring and post-burn contractures , and decreases the need of debridement irrespective of time of admission , when compared to SSD dressing Background R and omized trials are essential in assessing the effects of healthcare interventions and are a key component in systematic review s of effectiveness . Search ing for reports of r and omized trials in data bases is problematic due to the absence of appropriate indexing terms until the 1990s and inconsistent application of these indexing terms thereafter . Objectives The objectives of this study are to devise a search strategy for identifying reports of r and omized trials in EMBASE which are not already indexed as trials in MEDLINE and to make these reports easily accessible by including them in the Cochrane Central Register of Controlled Trials ( CENTRAL ) in The Cochrane Library , with the permission of Elsevier , the publishers of EMBASE . Methods A highly sensitive search strategy was design ed for EMBASE based on free-text and thesaurus terms which occurred frequently in the titles , abstract s , EMTREE terms ( or some combination of these ) of reports of trials indexed in EMBASE . This search strategy was run against EMBASE from 1980 to 2005 ( 1974 to 2005 for four of the terms ) and records retrieved by the search , which were not already indexed as r and omized trials in MEDLINE , were downloaded from EMBASE , printed and read . An analysis of the language of publication was conducted for the reports of trials published in 2005 ( the most recent year completed at the time of this study ) . Results Twenty-two search terms were used ( including nine which were later rejected due to poor cumulative precision ) . More than a third of a million records were downloaded and scanned and approximately 80,000 reports of trials were identified which were not already indexed as r and omized trials in MEDLINE . These are now easily identifiable in CENTRAL , in The Cochrane Library . Cumulative sensitivity ranged from 0.1 % to 60 % and cumulative precision ranged from 8 % to 61 % . The truncated term ' r and om$ ' identified 60 % of the total number of reports of trials but only 35 % of the more than 130,000 records retrieved by this term were reports of trials . The language analysis for the sample year 2005 indicated that of the 18,427 reports indexed as r and omized trials in MEDLINE , 959 ( 5 % ) were in language s other than English . The EMBASE search identified an additional 658 reports in language s other than English , of which the highest number were in Chinese ( 320 ) . Conclusion The results of the search to date have greatly increased access to reports of trials in EMBASE , especially in some language s other than English . The search strategy used was subjectively derived from a small ' gold st and ard ' set of test records and was not vali date d in an independent test set . We intend to design an objective ly-derived vali date d search strategy using logistic regression based on the frequency of occurrence of terms in the approximately 80,000 reports of r and omized trials identified compared with the frequency of these terms across the entire EMBASE data base Acticoat , a new silver-coated dressing , produces a moist healing environment along with the sustained release of ionic silver for improved microbial control . These properties suggest that Acticoat might be a useful donor site dressing . However , there are no human studies which assess Acticoat for this use . The purpose of this study was to compare the healing of human skin graft donor sites dressed with Acticoat , to the healing of those dressed with Allevyn , an occlusive moist-healing environment material , which is our st and ard donor site dressing . In burn patients who had undergone burn excision and grafting , identical side-by-side split thickness donor site wound pairs were dressed with Allevyn and Acticoat .  Re-epithelialization was directly assessed daily by a single observer from post-operative day 6 onward , and by four independent observers who rated the extent of re-epithelialization by viewing st and ardized digital images of the wounds that had been obtained on post-operative days 6 , 8 , 10 , and 12 . Donor sites were swabbed for bacterial culture on days 3 , 6 , and 9 . Subsequently , each study donor site scar was rated by a blinded observer using the Vancouver Scar Scale at 1 , 2 , and 3 months . Sixteen paired sites in 15 patients ( 3 female , 12 male ) were studied . Donor sites dressed with Allevyn were > 90 % re-epithelialized at a mean of 9.1+/-1.6 days while donor sites dressed with Acticoat required a mean of 14.5+/-6.7 days to achieve > 90 % re-epithelialization ( P=0.004 ) . The Allevyn sites had significantly greater estimated re-epithelialization at days 6 , 8 , 10 and 12 than the Acticoat sites based on the observations of the digital images . There were no significant differences in the incidence of positive bacterial cultures with either dressing at days 3 , 6 , and 9 . Donor sites dressed with Acticoat had significantly worse scars at 1 and 2 months but this difference resolved by 3 months . Our findings do not support the use of Acticoat as a skin graft donor site dressing OBJECTIVE To explore the influence of silver nanoparticle dressing on prevention of infection and healing of the second degree burn wound . METHODS One hundred and ninety-one burn patients with second degree including superficial and deep burn wound were r and omly divided into three groups . Group A including 65 cases was treated by silver nanoparticle dressing on wounds , and group B ( 63 cases ) and group C ( 63 cases ) were treated by 1 % silver sulfadiazine cream and vaseline gauze on their wounds , respectively . Dressing was changed daily , and wound swab bacterial cultures were performed before and after dressing change , and also wound healing times were recorded in each patient . RESULTS Group A and B were similar in their bacterium colonizations on wound after treatment with the silver nanoparticle dressing and 1 % silver sulfadiazine cream , and they had a similar effect on reducing bacterium colonization on wound after treatment , while in vaseline gauze group bacterium colonization on wound increased after treatment . In group A the wound healing time of superficial second degree was significantly shorter than those in group B and group C ( P < 0.01 ) . In deep second degree wounds the healing time in group A was much shorter than that in group C ( P < 0.01 ) , but had no significant difference when compared with group B ( P > 0.05 ) . CONCLUSION Silver nanoparticle dressing can be used on second degree burn wound and can decrease the risk of wound infection and accelerate wound healing Mepitel is a new grid like silicone coated nylon dressing containing no additional biological compounds . We describe a prospect i ve r and omized pilot study comparing Mepitel to the st and ard silver sulfadiazine cream ( Flamazine ) dressing for the topical treatment of paediatric burns . Seventy-six children presenting within 24 h of injury with a non previously treated burn were r and omly assigned to Mepitel  treatment ( group M ) or Flamazine treatment ( group F ) . Age , sex , surface area of burn and causal agent were noted at admission . The depth of the burn , cumulative number of dressings , presence or absence of a complete epithelial cover , infection , bleeding and allergy were 
    Output:
    
Our review suggests that silver-containing dressings and topical silver were either no better or worse than control dressings in preventing wound infection and promoting healing of burn wounds