***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background Patients often seek other patients ’ experiences with the disease . The Internet provides a wide range of opportunities to share and learn about other people ’s health and illness experiences via blogs or patient-initiated online discussion groups . There also exists a range of medical information devices that include experiential patient information . However , there are serious concerns about the use of such experiential information because narratives of others may be powerful and pervasive tools that may hinder informed decision making . The international research network DIPEx ( Data base of Individual Patients ’ Experiences ) aims to provide scientifically based online information on people ’s experiences with health and illness to fulfill patients ’ needs for experiential information , while ensuring that the presented information includes a wide variety of possible experiences . Objective The aim is to evaluate the colorectal cancer module of the German DIPEx website krankheitserfahrungen.de with regard to self-efficacy for coping with cancer and patient competence . Methods In 2015 , a Web-based r and omized controlled trial was conducted using a two-group between-subjects design and repeated measures . The study sample consisted of individuals who had been diagnosed with colorectal cancer within the past 3 years or who had metastasis or recurrent disease . Outcome measures included self-efficacy for coping with cancer and patient competence .  Participants were r and omly assigned to either an intervention group that had immediate access to the colorectal cancer module for 2 weeks or to a waiting list control group . Outcome criteria were measured at baseline before r and omization and at 2 weeks and 6 weeks Results The study r and omized 212 persons . On average , participants were 54 ( SD 11.1 ) years old , 58.8 % ( 124/211 ) were female , and 73.6 % ( 156/212 ) had read or heard stories of other patients online before entering the study , thus excluding any influence of the colorectal cancer module on krankheitserfahrungen.de . No intervention effects were found at 2 and 6 weeks after baseline . Conclusions The results of this study do not support the hypothesis that the website studied may increase self-efficacy for coping with cancer or patient competencies such as self-regulation or managing emotional distress . Possible explanations may involve characteristics of the website itself , its use by participants , or method ological reasons . Future studies aim ed at evaluating potential effects of websites providing patient experiences on the basis of method ological principles such as those of DIPEx might profit from extending the range of outcome measures , from including additional measures of website usage behavior and users ’ motivation , and from exp and ing concepts , such as patient competency to include items that more directly reflect patients ’ perceived effects of using such a website . Trial Registration Clinical trials.gov NCT02157454 ; https:// clinical trials.gov/ct2/show/NCT02157454 ( Archived by WebCite at http://www.webcitation.org/6syrvwXxi Background The use of a mobile health care application , the delivery of health care or health care‐related services through the use of portable devices , to manage functional loss , treatment‐related toxicities , and impaired quality of life in cancer patients during chemotherapy through supervised self‐management has been increasing . The aim of the present study was to evaluate the efficacy and feasibility of comprehensive mobile health care using a tailored rehabilitation program for colorectal cancer patients undergoing active chemotherapy . Patients and Methods A total of 102 colorectal cancer patients undergoing chemotherapy underwent 12 weeks of  smartphone aftercare through provision of a mobile application and wearable device that included a rehabilitation exercise program and information on their disease and treatment .  The grip strength test , 30‐second chair st and test , 2‐minute walk test , amount of physical activity ( International Physical Activity Question naire short‐form ) , quality of life ( European Organization for Research and Treatment of Cancer Quality of Life Question naire C30 ) , and nutritional status ( Patient‐generated Subjective Global Assessment ) were assessed and measured at baseline , at mid‐intervention ( 6 weeks ) , and at completion of the intervention ( 12 weeks ) . The rehabilitation exercise intensity was adjusted by the test results at every assessment and through real‐time communication between the patients and clinicians . Results Of the 102 patients , 75 completed all 12 weeks of the smartphone aftercare rehabilitation program . The lower extremity strength ( P < .001 ) and cardiorespiratory endurance ( P < .001 ) was significantly improved . Fatigue ( P < .007 ) and nausea/vomiting ( P < .040 ) symptoms were significantly relieved after the program . Conclusion A tailored rehabilitation exercise program provided through a comprehensive mobile health care application was effective in improving patients ' physical capacity and treatment‐related symptoms even during active chemotherapy . Micro‐ Abstract The use of mobile health care applications is a method increasing in use in the cancer care continuum from cancer prevention to cancer diagnosis , cancer treatment , and cancer survivorship . However , no clinical study has yet investigated the effects and feasibility of a smartphone application‐based personalized exercise intervention for colorectal cancer patients undergoing chemotherapy . In 75 colorectal cancer patients undergoing active chemotherapy , a rehabilitation program using a mobile health care application on a wearable device was effective in improving physical function and relieving cancer‐ and cancer treatment‐related toxicities , regardless of the chemotherapy duration Background Cancer survivors have to deal with a wide range of physical symptoms , psychological , social and existential concerns , and lifestyle issues related to cancer and its treatment . Therefore , it is essential that they have access to optimal supportive care services . The eHealth self-management application Oncokompas was developed to support cancer survivors with where they need to turn to for advice and guidance , as well as to increase their knowledge on the availability of optimal support . A r and omised controlled trial will be conducted to assess the efficacy , cost-utility and reach of Oncokompas as an eHealth self-management application compared with care as usual among cancer survivors . Methods / design Adult cancer survivors diagnosed with breast , colorectal or head and neck cancer or lymphoma who are at 3 months to 5 years since curative treatment will be included . In total , 544 cancer survivors will be r and omly assigned to the intervention group or a wait-list control group . The primary outcome measure is patient activation . Secondary outcome measures include self-efficacy , personal control , perceived patient-physician interaction , need for supportive care , mental adjustment to cancer and health-related quality of life . Furthermore , cost-utility outcomes will be assessed . Reach is defined as the percentage of cancer survivors who get access to Oncokompas within the context of this trial . Question naires will be administered at baseline , post-intervention and at 3- and 6-month follow-up . Discussion In this study , we will evaluate the efficacy and cost-utility of Oncokompas among cancer survivors , as well as the reach of Oncokompas . These are essential first steps in the translation of research into practice and contribute to sustainable adoption , implementation and maintenance of an evidence -based Oncokompas . Trial registration Netherl and s Trial Register identifier : NTR5774 . Registered on 8 March 2016 Background Cancer and cancer treatment coincide with substantial negative physical , psychological and psychosocial problems .  Physical activity ( PA ) can positively affect the negative effects of cancer and cancer treatment and thereby increase quality of life in CPS . Nevertheless , only a minority of CPS meet PA guidelines . We developed the OncoActive ( OncoActief in Dutch ) intervention : a computer-tailored PA program to stimulate PA  in prostate and colorectal CPS , because to our knowledge there are only a few PA interventions for these specific cancer types in the Netherl and s Methods The OncoActive intervention was developed through systematic adaptation of a proven effective , evidence -based , computer-tailored PA  intervention for adults over fifty , called Active Plus . The Intervention Mapping ( IM ) protocol was used to guide the systematic adaptation . A literature study and interviews with prostate and colorectal CPS and health care professionals revealed that both general and cancer-specific PA determinants are important and should be addressed . Change objectives , theoretical methods and applications and the actual program content were adapted to address the specific needs , beliefs and cancer-related issues of prostate and colorectal CPS . Intervention participants  received tailored PA advice three times , on internet and with printed material s , and a pedometer to set goals to improve PA .  Pre- and pilot tests showed that the intervention was highly appreciated ( target group ) and regarded safe and feasible ( healthcare professionals ) . The effectiveness of the intervention is being evaluated in a r and omized controlled trial ( RCT ) ( n = 428 ) , consisting of an intervention group and a usual care waiting-list control group , with follow-up measurements at three , six and twelve months . Participants are recruited from seventeen hospitals and with posters , flyers and calls in several media . Discussion Using the Intervention Mapping protocol result ed in a systematic ally adapted , theory and evidence -based intervention providing tailored PA advice to prostate and colorectal CPS . If the intervention turns out to be effective in increasing PA , as evaluated in a RCT , possibilities for nationwide implementation and extension to other cancer types will be explored . Trial registration The study is registered in the Dutch Trial Register ( NTR4296 ) on November 23rd 2013 and can be accessed at http://www.trialregister.nl/trialreg/admin/ rct view.asp?TC=4296 Background / Objective : Colorectal and gynecologic cancer survivors are at cardiovascular risk due to comorbidities and sedentary behaviour , warranting a feasible intervention to increase physical activity . The Health Action Process Approach ( HAPA ) is a promising theoretical framework for health behaviour change , and wearable physical activity trackers offer a novel means of self-monitoring physical activity for cancer survivors . Method : Sixty-eight survivors of colorectal and gynecologic cancer will be r and omised into 12-week intervention and control groups . Intervention group participants will receive : a Fitbit Alta ™ to monitor physical activity , HAPA-based group sessions , booklet , and support phone-call . Participants in the control group will only receive the HAPA-based booklet . Physical activity ( using accelerometers ) , blood pressure , BMI , and HAPA constructs will be assessed at baseline , 12-weeks ( post-intervention ) and 24-weeks ( follow-up ) . Data analysis will use the Group x Time interaction from a General Linear Mixed Model analysis . Conclusions : Physical activity interventions that are acceptable and have robust theoretical underpinnings show promise for improving the health of cancer survivors Purpose This r and omized controlled trial evaluated the impact of SurvivorCHESS , an eHealth intervention , on physical activity in colon cancer survivors and to explore the impact of SurvivorCHESS on quality of life and distress . Methods This was a two-arm single-blinded multi-site r and omized controlled trial comparing a control group to an intervention group receiving a smartphone with the SurvivorCHESS program . Results Participants using SurvivorCHESS ( n = 144 ) increased their moderate to vigorous physical activities from 19.4 min at baseline to 50 min compared to the control  group ( n = 140 ) increasing from 15.5 to 40.3 min at 6 months ( p = .083 ) but was not sustained 3 months after the study ended . No significant differences were found between groups over time for quality of life or distress items . Reports of physical symptoms were greater than other categories for distress items . Patients who had a higher body mass index and number of comorbid conditions were less likely to increase their physical activity . Self-determination theory including autonomous motivation and relatedness was not associated with the outcomes . Conclusions Physical activity did increase over time in both groups and was not significantly different with the use of the eHealth intervention , SurvivorCHESS , compared to the control group . The amount of SurvivorCHESS use was not associated with physical activity . Implication s for cancer survivorsIncreasing physical activity in colon cancer survivors has the potential to improve quality of life and reduce recurrences . Using smartphone-tracking devices may be useful in helping to change this health behavior Introduction While some evidence exists that real-time remote symptom monitoring devices can decrease morbidity and prevent unplanned admissions in oncology patients , overall , these studies have significant method ological weaknesses . The electronic Symptom Management using the Advanced Symptom Management System ( ASyMS ) Remote Technology ( eSMART ) study is design ed to specifically address these weaknesses with an appropriately powered , repeated- measures , parallel-group stratified r and omised controlled trial of oncology patients . Methods and analysis A total of 1108 patients scheduled to commence first-line chemotherapy ( CTX ) for breast , colorectal or haematological cancer will be recruited from multiple sites across five European countries . Patients will be r and omised ( 1:1 ) to the  ASyMS intervention ( intervention group ) or to st and ard care currently available at each site ( control group ) . Patients in the control and intervention groups will complete a demographic and clinical question naire , as well as a set of valid and reliable electronic patient-reported outcome measures at enrolment , after each of their CTX cycles ( up to a maximum of six cycles ) and at 3 , 6 , 9 and 12 months after completion of their sixth cycle of CTX . Outcomes that will be assessed include symptom burden ( primary outcome ) , quality of life , supportive care needs , anxiety , self-care self-efficacy , work limitations and cost effectiveness and , from a health professional perspective , changes in clinical practice ( secondary outcomes ) . Ethics and dissemination Ethical approval will be obtained prior to the implementation of all major study amendments . Applications will be su bmi tted to all of the ethics committees that granted initial approval . eSMART received approval from the relevant ethics committees at all of the clinical sites across the five participating countries . In collaboration with the European Cancer Patient Coalition ( ECPC ) , the trial results will be disseminated through publications in scientific journals , presentations at international conferences , and postings on 
    Output:
    
eHealth could provide useful services for supporting colorectal cancer survivors .