***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: A DOUBLE-BLIND study on the effect of betamethasone sodium phosphate in the treatment of 297 infants and children with acute bronchiolitis was conducted at five hospitals from December 1963 to June 1965 . For this study , the investigators design ed a common protocol and st and ard case report forms for use at the five collaborating centers . The information obtained permitted an evaluation of the effects of the  corticosteroid  in bronchiolitis and provided further insight into the natural history of the disease . The study was not design ed to explore the causes of bronchiolitis or the effect of supportive treatment . In recent years , corticosteroids have been used in the treatment of bronchiolitis on the hypothesis that their anti-inflammatory action would reduce bronchiolar inflammation and swelling . These drugs have been regarded as ineffective by some investigators and lifesaving by others . In 1964 , Sussman et al1reported no change in the clinical course of 49 arthritis , particularly with actively inflamed large joints , and ankylosing spondylitis . The fact that indomethacin is a rapidly effective , non-steroidal , anti-inflammatory agent , like phenylbutazone , makes it a useful alternative to predni-steroid therapy . As with many other drugs used in the treatment of chronic rheumatic disorders , indomethacin causes undesired effects which are particularly apt to occur in the early stages of treatment . Fortunately most of these are trivial and clear rapidly after withdrawal of the drug . In view of the occurrence of severe neurological disturbance in seven of our cases we feel that it would be unwise to ignore and dangerous to suppress the headache and associated symptoms so commonly encountered . If these can not be avoided by gradual induction or by subsequent reduction of dosage , they must be taken as an indication for stopping the drug . It would seem reasonable to insist that indomethacin should only be given with caution to any patient with a history of depressive illness . Active or recent peptic ulceration should be regarded as an absolute contraindication , and therapy should not be resumed in any patient who exhibits a rash during treatment A double blind trial of prednisolone treatment was carried out on 95 children with clinical evidence of epidemic bronchiolitis . The trial showed that there was no difference between the prednisoIone and the placebo group in the duration of symptoms and signs 
    Output:
    
Studies in the United States,9 Canada,10 and the Netherl and s11 showed variations that correlated more with hospital or individual preferences than with patient severity .