***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Objective : This study investigated changes in the quality of life of men and women who participated in a primary care-based weight loss intervention program .  Methods : Participants were enrolled in a 2-year r and omized clinical trial ( POWER-UP ) conducted at the University of Pennsylvania and in six affiliated primary care practice s. Inclusion criteria included the presence of obesity ( body mass index of 30–50 kg m−2 ) and at least two components of the metabolic syndrome . Main Outcome Measures : Quality of life was assessed by three measures : the Short Form Health Survey ( SF-12 ) ; the Impact of Weight on Quality of Life-Lite ; and the EuroQol-5D . Results : Six months after the onset of treatment , and with a mean weight loss of 3.9±0.3 kg , participants reported significant improvements on all measures of interest with the exception of the Mental Component Score of the SF-12 . These changes remained significantly improved from baseline to month 24 , with the exception of the EuroQol-5D . Many of these improvements were correlated with the magnitude of weight loss and , for the most part , were consistent across gender and ethnic group . Conclusions : Individuals with obesity and components of the metabolic syndrome reported significant improvements in most domains of the quality of life with a modest weight loss of 3.7 % of initial weight , which was achieved within the first 6 months of treatment . The majority of these improvements were maintained at month 24 , when participants had lost 3.0 % of their weight OBJECTIVES To investigate the relationship between cognitive performance , affective state , metabolic syndrome and 7-year follow-up self-rated health ( SRH ) and perceived life satisfaction ( PLS ) . DESIGN Analysis of a prospect i ve cohort study . SETTING The PROOF study , including 1011 elderly community residents . PARTICIPANTS Six hundred and fifty seven subjects completed metabolic syndrome ( Met S ) variables , neuropsychological and affective measurements at baseline , and then returned a 7-year follow-up question naire which included SRH and PLS . MEASUREMENTS The prospect i ve association between cognitive function , Met S and each of its components , and affective disorders and subsequent subjective health and quality of life was examined . Covariates included educational level and use of tobacco . The analyses were made in men and women separately . RESULTS In multivariate models , the presence of Met S was significantly associated to weaker SRH ( OR = 2.78 , p = 0.009 in men and OR = 2.0 , p = 0.02 in women ) . Higher triglycerides rate were associated with weaker SRH in men ( OR = 2.23 , p = 0.002 ) and higher fasting glucose in women ( OR = 2.54 , p = 0.006 ) . Global Met S and abdominal obesity was significantly associated to weaker PLS in women only ( respectively OR = 2.70 , p = 0.0002 and OR = 1.9 , p = 0.02 ) . Depressive symptoms were significantly associated to both weaker SRH and PLS in men ( OR = 1.30 , p = 0.002 ; OR = 1.44 , p < 0.0001 for SRH and PLS respectively ) and in woman ( OR = 1.09 , p = 0.04 ; OR = 1.26 , p < 0.0001 for SRH and PLS respectively ) . Anxiety was linked to both weaker SRH and PLS in women ( OR = 1.17 , p = 0.002 and 0R = 1.11 , p = 0.03 for SRH and PLS respectively ) . Finally , lower executive function was associated with weaker PLS in men ( OR = 0.43 , p = 0.0005 ) . CONCLUSION metabolic syndrome and certain of its components , anxiety and depressive symptoms , are independent predictors of poorer subjective health and quality of life as assessed over a period of 7 years in a population of a non-demented aging community . Moreover , executive performance was linked to subsequent quality of life in men . Many of these factors being treatable , our findings point to the necessity of providing preventive care strategies by the management of cardiovascular risk factors and anxio-depressive symptoms BACKGROUND Few r and omized controlled trials on lifestyle interventions have been reported in non-Western population s ; none have been reported in Arab population s. METHODS From 2 Muslim Arab communities in Israel , obese , nondiabetic women aged 35 to 54 years with 1 or more components of the metabolic syndrome were r and omized to either an intensive ( n = 100 ) or a moderate ( control ) ( n = 101 ) 12-month lifestyle intervention . Women in the intensive intervention had 11 individual and 11 group counseling sessions per year with a dietitian and 22 physical activity group sessions per year . Women in the moderate intervention had 3 individual and 2 group dietary counseling sessions per year and no guided physical activity . Cultural issues were addressed in the design and conduct of both interventions . The primary outcome measure was change in the metabolic syndrome and its components . RESULTS At 12 months , the intensive intervention group had median declines of 3.0 mg/dL ( to convert to millimoles per liter , multiply by 0.0555 ) in fasting plasma glucose and 4.5 mg/dL ( to convert to millimoles per liter , multiply by 0.0113 ) in triglyceride levels compared with median increases of 1 mg/dL in fasting plasma glucose and 5.8 mg/dL in triglyceride levels in the moderate intervention group ( P = .01 and P = .02 , respectively ) . The median waist circumference decreased by 5.4 cm in the intensive intervention group and by 3.1 cm in the moderate intervention group ( P = .10 ) . The prevalence of the metabolic syndrome decreased by 4.0 % in the intensive intervention group and increased by 5.2 % in the moderate intervention group ( P = .12 ) . CONCLUSION The 12-month culturally sensitive intensive lifestyle intervention was effective in improving some of the metabolic syndrome components in obese Arab women . Trial Registration clinical trials.gov Identifier : NCT00273572 
    Output:
    
Almost all studies suggested that metabolic syndrome is significantly associated with impaired quality of life .
Some , however , found association only in women , or only if associated with depression or Body Mass Index .
Conclusion : although there are a few studies available about the relationship between metabolic syndrome and quality of life , a growing body of evidence has shown significant association between metabolic syndrome and the worsening of quality of life .