***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: PURPOSE To compare the results of short-course vs. long-course radiotherapy ( RT ) for metastatic spinal cord compression . METHODS AND MATERIAL S A total of 231 patients who underwent RT between January 2006 and August 2007 were included in this two-arm prospect i ve nonr and omized study . Patients received short-course ( n = 114 ) or long-course ( n = 117 ) RT . The primary endpoint was progression-free survival ( PFS ) . The secondary endpoints were local control ( LC ) , functional outcome , and overall survival ( OS ) . An additional 10 potential prognostic factors were investigated for outcomes . PFS and LC were judged according to motor function , not pain control . RESULTS The PFS rate at 12 months was 72 % after long-course and 55 % after short-course RT ( p = 0.034 ) . These results were confirmed in a multivariate analysis ( relative risk , 1.33 ; 95 % confidence interval , 1.01 - 1.79 ; p = 0.046 ) . The 12-month LC rate was 77 % and 61 % after long-course and short-course RT , respectively ( p = 0.032 ) . These results were also confirmed in a multivariate analysis ( relative risk , 1.49 ; 95 % confidence interval , 1.03 - 2.24 ; p = 0.035 ) . The corresponding 12-month OS rates were 32 % and 25 % ( p = 0.37 ) . Improvement in motor function was observed in 30 % and 28 % of patients undergoing long-course vs. short-course RT , respectively ( p = 0.61 ) . In addition to radiation schedule , PFS was associated with the interval to developing motor deficits before RT ( relative risk , 1.99 ; 95 % confidence interval , 1.10 - 3.55 ; p = 0.024 ) . LC was associated only with the radiation schedule . Post-RT motor function was associated with performance status ( p = 0.031 ) , tumor type ( p = 0.013 ) , interval to developing motor deficits ( p = 0.001 ) , and bisphosphonate administration ( p = 0.006 ) . OS was associated with performance status ( p < 0.001 ) , number of involved vertebrae ( p = 0.007 ) , visceral metastases ( p < 0.001 ) , ambulatory status ( p < 0.001 ) , and bisphosphonate administration ( p < 0.001 ) . CONCLUSION Short-course and long-course RT result ed in similar functional outcome and OS . Long-course RT was significant for improved PFS and improved LC 
    Output:
    
The review indicated that 10 and 6 Gy may produce superior overall response ( OR ) and complete response ( CR ) rates compared to 8 Gy , and 6 Gy may result in better partial response ( PR ) than 8 Gy .
8 Gy SFRT was the most commonly administered dose for palliation of bone metastases supporting its efficacy and safety .