***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background There is evidence that bisphosphonates can improve fixation of cementless metal implants by enhancing the extent of osseointegration . The current pre clinical study examined whether the nitrogen-containing bisphosphonate ib and ronate can accelerate this process , result ing in early achievement of secondary stability and sealing of the bone – implant interface to prevent wear debris migration . Methods The study was conducted on 88 female Sprague-Dawley rats in which uncoated titanium and hydroxyapatite-coated titanium implants were surgically inserted into the medullary canal of each femur . The animals were r and omly assigned to receive subcutaneous treatment with 1.0 , 2.5 , or 5.0 µg/kg per day ib and ronate or saline solution as a control . The extent of osseointegration expressed by the osseointegrated implant surface was quantified by histomorphometry at eleven time points during the study period . To determine the time course of osseointegration , the data were expressed using third-order polynomial regression analysis . Results For hydroxyapatite-coated implants , the highest dose of ib and ronate ( 5 µg ) reduced the time for a sufficient implant fixation of 60 % osseointegrated implant surface to 18 days compared to 38 days in the control group . This reduction of 20 days ( 52.6 % ) represents a halving in the time required for sufficient osseointegration of the implant . For hydroxyapatite-coated implants and low-dose ib and ronate application ( 1 µg , 2.5 µg ) and for uncoated titanium implants , acceleration of osseointegration was not observed in any of the study arms . Conclusion Continuous treatment with 5 µg/kg per day ib and ronate is potent in accelerating osseointegration of hydroxyapatite-coated implants . As a result , improved early secondary stability and prevention of wear debris migration by the sealing of the implant – bone interface can be expected , therefore prolonging the long-term survival of the implant The quality of bone plays an important role in the long-term clinical success of dental implant treatment . An interim evaluation of the relationship between bone quality and the incidence of failure at second-stage surgery is presented . The data include 2,131 root form implants placed by the Dental Implant Clinical Research Group over the past three years . Trends to date suggest differences in the rates of osseointegration among the various bone qualities . Quality 1 bone experienced the greatest failure rate , whereas quality 2 and quality 3 bone had the lowest failure rates . ( Implant Dent 1994;3:252–255 Aseptic bone loss adjacent to orthopedic joint implants is a common cause of joint implant failure in humans . This study investigates the expression of key regulators of osteoclast formation , receptor activator NFkappaB ( RANK ) , Receptor activator of NFkappaB lig and ( RANKL ) and  osteoprotegerin ( OPG )  , in the peri-implant tissues of patients with osteolysis compared with levels in synovial tissues from osteoarthritic and healthy subjects . Immunohistochemical studies demonstrated that significantly higher levels of  RANKL protein ( p<0.05 ) were found in the peri-implant tissues of patients with implant failure than in similar tissues from osteoarthritic and healthy subjects . In contrast , OPG protein levels were similar in all tissues . RANKL , expressed as mRNA and protein , was predominantly associated with cells containing wear particles . Dual labeling studies showed that the cells expressing RANKL protein were macrophages . In situ hybridization studies confirmed that mRNA encoding for these proteins is also expressed by cells in the peri-implant tissues . In addition , RANK mRNA was expressed in cells that contained wear particles . These findings show that abnormally high levels of RANKL are expressed in peri-implant tissues of patients with prosthetic loosening and that these abnormal levels of RANKL may significantly contribute to aseptic implant loosening 
    Output:
    
Many factors related to implant drill responsible for heat generation were found .
Successful preparation of an implant cavity with minimal damage to the surrounding bone depends on the avoidance of excessive temperature generation during surgical drilling .