***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background Supporting 21st century health care and the practice of evidence -based medicine ( EBM ) requires ubiquitous access to clinical information and to knowledge-based re sources to answer clinical questions . Many questions go unanswered , however , due to lack of skills in formulating questions , crafting effective search strategies , and accessing data bases to identify best levels of evidence . Methods This r and omized trial was design ed as a pilot study to measure the relevancy of search results using three different interfaces for the PubMed search system . Two of the search interfaces utilized a specific framework called PICO , which was design ed to focus clinical questions and to prompt for publication type or type of question asked . The third interface was the st and ard PubMed interface readily available on the Web . Study subjects were recruited from interns and residents on an inpatient general medicine rotation at an academic medical center in the US . Thirty-one subjects were r and omized to one of the three interfaces , given 3 clinical questions , and asked to search PubMed for a set of relevant articles that would provide an answer for each question . The success of the search results was determined by a precision score , which compared the number of relevant or gold st and ard articles retrieved in a result set to the total number of articles retrieved in that set . Results Participants using the PICO templates ( Protocol A or Protocol B ) had higher precision scores for each question than the participants who used Protocol C , the st and ard PubMed Web interface . ( Question 1 : A = 35 % , B = 28 % , C = 20 % ; Question 2 : A = 5 % , B = 6 % , C = 4 % ; Question 3 : A = 1 % , B = 0 % , C = 0 % ) 95 % confidence intervals were calculated for the precision for each question using a lower boundary of zero . However , the 95 % confidence limits were overlapping , suggesting no statistical difference between the groups . Conclusion Due to the small number of search es for each arm , this pilot study could not demonstrate a statistically significant difference between the search protocol s. However there was a trend towards higher precision that needs to be investigated in a larger study to determine if PICO can improve the relevancy of search results We examined the response of net muscle protein synthesis to ingestion of amino acids after a bout of resistance exercise . A primed , constant infusion ofl- [ ring-2H5]phenylalanine was used to measure net muscle protein balance in three male and three female volunteers on three occasions . Subjects consumed in r and om order 1 liter of 1 ) a mixed amino acid ( 40 g ) solution ( MAA ) , 2 ) an essential amino acid ( 40 g ) solution ( EAA ) , and 3 ) a placebo solution ( PLA ) . Arterial amino acid concentrations increased ∼150 - 640 % above baseline during ingestion of MAA and EAA . Net muscle protein balance was significantly increased from negative during PLA ingestion ( -50 ± 23 nmol ⋅ min-1 ⋅ 100 ml leg volume-1 ) to positive during MAA ingestion ( 17 ± 13 nmol ⋅ min-1 ⋅ 100 ml leg volume-1 ) and EAA ( 29 ± 14 nmol ⋅ min-1 ⋅ 100 ml leg volume-1 ; P < 0.05 ) . Because net balance was similar for MAA and EAA , it does not appear necessary to include nonessential amino acids in a formulation design ed to elicit an anabolic response from muscle after exercise . We concluded that ingestion of oral essential amino acids results in a change from net muscle protein degradation to net muscle protein synthesis after heavy resistance exercise in humans similar to that seen when the amino acids were infused 
    Output:
    
Human biofluids contain mainly unphosphorylated metabolites as the phosphorylation of metabolites such as ATP , glycolytic intermediates , or nucleotides traps these metabolites within cells .
Lactate , pyruvate , TCA cycle intermediates , fatty acids , acylcarnitines , and ketone bodies all typically increase after exercise , whereas bile acids decrease .
In contrast , the concentrations of proteinogenic and non-proteinogenic amino acids change in different directions .
Across different exercise modes and in different subjects , exercise often consistently changes the average concentrations of metabolites that belong to energy metabolism and other branches of metabolism .