***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: The present study compares visible-light Delton with Duraphat fluoride varnish for the prevention of occlusal caries in permanent first molars . A clinical trial was carried out in three groups of 6 - 8-yr-old schoolchildren : a sealant group ( 100 children ) , in which Delton light-polymerized fissure sealant was applied to permanent first molars ; a varnish group ( 98 children ) , in which Duraphat was applied to permanent first molars ; and a control group ( 116 children ) .  Replacement ( sealant ) and reapplication ( varnish ) was carried out every 6 months . Percent effectiveness at 24 months ( percentage of saving from caries taking molars as analysis unit ) for those molars initially healthy and with complete occlusal eruption was analyzed . 272 , 252 and 238 molars met the inclusion criteria in the control , varnish and sealant groups , respectively . Of these , 45.2 % , 28.2 % and 10.5 % developed caries after 24 months . The effectiveness was greater in the sealed molars than in the varnished molars ( 62.7 % ) PURPOSE The aim of this work is to study and compare the retention rate , caries-preventing and antibacterial effects of resin-modified glass ionomer and flowable composite in comparison to conventional fissure sealant . METHODS Forty-five children aged 7 - 10 years with newly erupted lower first permanent molars were r and omly divided into three equal treatment groups . Group I : sealed by a conventional resin sealant ; Group II : sealed by resin modified glass ionomer ( RMGI ) ; and Group III : sealed by flowable composite .  Retention and caries status of the sealed teeth were recorded after 1 month , 6 months , year and 2 years . In addition , Streptococcus mutans counts were assessed at baseline , 1 day , 1 month , 6 months , 1 year and 2 years after sealant application . Data were analyzed by Fisher exact , chi-square and ANOVA tests . RESULTS Group III and Group I showed significantly higher retention rates than Group II fissure sealant ( p<0.05 ) . There were no differences of the caries-preventive effects between the tested sealant material s throughout the duration of the study . Streptococcus mutans counts were significantly lower in group II compared to group I or group III up to 6 months of the study ( p<0.05 ) . After 1 year of the study the differences of Streptococcus mutans counts were not significant ( p>0.05 ) . CONCLUSION This study indicated a lower retention of RMGI compared to flowable composite and resin sealant without significant difference in caries prevention or long-term bacterial inhibition A 24-month clinical study was carried out to evaluate and compare the retention rate , marginal integrity and caries preventing effects of a polyacid-modified resin composite based fissure sealant , Dyract Seal , to that of a resin based fluoride fissure sealant , Delton FS+ .  Fifty-three patients ( 27 female and 26 male ) , 7 to 10 years old , were included in the study . At baseline , a total of 192 permanent first molars were sealed with either fissure sealant ( n=96 , each ) , using invasive technique . The sealed teeth were evaluated at post-operative 3 , 6 , 12 and 24 months with respect to evaluation parameters . The data were analyzed with the Chi-Square tests where alpha=0.05 . There were no statistically significant differences between fissure sealants as regards to retention and prevention of caries for all periods of the evaluation ( p>0.05 ) . However , regarding marginal integrity of the sealants , Delton FS+ gave significantly better results than Dyract Seal for the 3- , 6- and 12-month evaluations , respectively ( p<0.05 ) . In conclusion , the use of  Dyract Seal on permanent molars with invasive technique was found to be clinical ly comparable to Delton FS+ for the 24-month evaluation period Abstract Fissure sealing using partially filled resins is an established caries preventive practice . Glass ionomer cement ( GIC ) sealants may offer additional advantages due to their ability to bond chemically to enamel and release fluoride . The aim of this study was to compare the caries preventive effect and retention of a GIC and a resin-based sealant . Ketac-fil ® was tested against a chemically cured resin-based material ( Delton ® ) using a split mouth design . Perth ( Western Australia ) schoolchildren ( n= 465 ) , mean age 7 yr±0.72 ( S.D. ) , received sealants  on the occlusal surfaces of sound homologous permanent first molar pairs .  Test ( GIC ) and control ( resin ) sealants were systematic ally allocated to left and right sides based on the child 's month of birth , and were placed by dental therapists . After 3.64±0.11 yr , 415 children were examined by different clinicians , and the clinical status of the teeth and the extent of sealant retention recorded . Sealants were deemed retained when at least 2/3 of the fissure pattern was still sealed . In 252 tooth pairs , neither sealant was retained to this extent . In 71 pairs , the GIC was not retained and the resin sealant retained . In 40 pairs the reverse occurred ( McNemar 's test , χ2= 8.66 , P < 0.005 ) . Net gain ( additional lesions prevented by the test agent per 100 treatments ) was 6.1%(95 % CI 3.3 % , 8.9 % ) . Effectiveness of the GIC was 80.6 % ( 95 % CI 59.6 % , 90.7 % ) . The relative risk of caries in test teeth was 0.19 ( 95 % CI 0.09 , 0.40 ) . The study suggests that complete retention of GIC sealant is not necessary for caries prevention in newly erupted permanent first molars PURPOSE To evaluate the retention and caries-preventive effectiveness of two ionomeric material s ( conventional and resin-modified ) , used as fissure sealants . MATERIAL S AND METHODS 100 children ( 6 - 8 years old ) with a total of 400 permanent first molars received  200 conventional glass-ionomer ( Ketac Bond ) and 200 resin-modified glass-ionomer ( Vitremer ) sealants .  Additionally , 108 children constituted the control group ( 432 teeth ) . Two dentists assisted by dental hygienists performed the sealant application . Clinical evaluations were carried out 6 , 12 , 24 , and 36 months after the sealant application by two other dentists , not carrying out clinical procedures , previously calibrated ( Kappa > 0.75 ) . RESULTS Total retention rates of 26 % , 12 % , 3 % , and 4 % for Ketac Bond and 61 % , 31 % , 14 % , and 13 % for Vitremer , being 6 , 12 , 24 , and 36 months after clinical evaluation , respectively . The differences between the two material s were statistically significant . The experimental groups showed a caries incidence of 93 % , 78 % , 49 % , and 56 % lower than the control group ( P < 0.01 ) for the four evaluation periods , respectively . In conclusion , the retention rates of ionomeric material s were low . Nevertheless , these material s showed a cariostatic effect , supported by statistically lower caries incidence in experimental groups compared to control group . Presence of active incipient caries was statistically associated with caries incidence in the first molars after 36 months , in relation to either experimental or control group To evaluate the retention and caries experience effects of three different material s used as fissure sealants after 24 months of clinical application : a resin-modified glass ionomer cement ( A ) , a flowable resin composite ( B ) and a compomer ( C ) .  One hundred and seventeen ( 117 ) teeth were sealed with material A , 119 teeth with material B and 120 teeth with material C. Children were r and omly assigned . Each one received only one of the material s studied .  Plaque index , dmft score and socioeconomic level were scored at baseline . The clinical exams were conducted 6 , 12 and 24 months after application of the sealant . Statistical analysis ( Kruskal-Wallis ) revealed that there were statistically significant differences between the retention rates of groups A and B and between groups B and C after 2 years , with material B showing better results . After 2 years , 3.1 % of the teeth of group A , 4.3 % of group B and 6.7 % of group C were Carious+Filled . There was no evidence of association between caries presence after 2 years and plaque index , dmft score and socioeconomic level . These results suggest that flowable resin composite had a satisfactory retention after this period of evaluation and all three material s were effective on occlusal caries prevention 
    Output:
    
They also concluded that sealants could minimize the progression of non-cavitated occlusal carious lesions ( also referred to as initial lesions ) that receive a sealant .
Finally , based on the available limited evidence , the panel was unable to provide specific recommendations on the relative merits of 1 type of sealant material over the others .