***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: We monitored fluphenazine plasma levels in 39 schizophrenic patients who participated in a 2-year double-blind comparison of 5 mg and 25 mg of fluphenazine decanoate ( FD ) administered every 14 days . We investigated the relationship between log-transformed plasma levels at 3 , 6 , and 9 months and subsequent psychotic exacerbations with logistic regression and survival analysis . Using logistic regression , the relationship was nonsignificant at 3 months ( chi-square = .21 , df = 1 , p = .65 ) , but significant at 6 months ( chi-square = 4.38 , df = 1 , p = .04 ) and 9 months ( chi-square = 8.98 , df = 1 , p = .003 ) . Using survival analysis with fluphenazine levels as a covariate ( Cox models ) , we also found significant relationships between the fluphenazine plasma level and the risk of exacerbations at 6 months ( chi-square = 3.77 , df = 1 , p = .052 ) and 9 months ( chi-square = 12.21 , df = 1 , p = .0005 ) , but not at three months ( chi-square = 0.87 , df = 1 , p = .65 ) . These findings suggest that the measurement of fluphenazine plasma levels may be helpful in decision-making about the dosage of FD A modification of an earlier rating scale for extrapyramidal system disturbance is described , and evidence for the validity and reliability of the scale is presented . The usefulness of the scale in studies of neuroleptic drugs is discussed . By its application it is possible to quantify extrapyramidal side effects and to separate them into four principal factors 
    Output:
    
There was no differences between the two for outcomes of global improvement , relapse and leaving the study early .