***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: The sensitivity of H. Pylori to antibiotic treatment is well known . Politherapy ( omeprazole or pantoprazole or ranitidine , amoxicillin and /or azithromycin and /or clarithromycin , metronidazole and bismuth citrate ) notably changed the percentage of H. pylori eradication but rarely resolutive . Periodontal pockets treatment with topic metronidazole , calcium sulphate and potassium sulphate  result ed active against bacteria included in periodontal pockets leading to a long-term H. pylori eradication ( two years follow-up ) Background and Aims Helicobacter pylori ( H. pylori ) is an important pathogen in gastritis , peptic ulcer and possibly gastric cancer , but several questions remain unanswered . Particularly how the organism is transmitted and what is the relationship between oral presence of H. pylori and the gastric infection . Accordingly , we aim ed to characterize the H. pylori in oral cavity and to evaluate its relationship to gastric H. pylori infection . Material s and Methods Out of total 100 screened for H. pylori infection female subjects ( 40 to 85 y ) , 49 patients ( pts ) , who had positive 13C-urea breath test ( UBT ) and dyspeptic symptoms , agreed for 1 week regimen of triple anti-H. pylori therapy .  The presence of H. pylori in oral cavity was assessed using bacterial culture from saliva and gingival pockets . Gastric H. pylori infection was estimated using capsulated 13C-urea breath test and plasma anti-H. pylori IgG and saliva IgA antibodies . In addition , plasma gastrin , ghrelin , and pepsinogen I were measured by radioimmunoassay . In selected patients , gastroscopy was additionally performed and gastric biopsy sample s were taken for H. pylori r and om amplification of polymorphic DNA genetic profiling . Results The triple therapy result ed in gastric H. pylori eradication in 79 % pts , along with significant decrease of plasma gastrin combined with an increase in plasma ghrelin and pepsinogen I ( PgI ) levels and a marked alleviation of dyspeptic symptoms . In contrast to gastric effects , the eradication therapy failed to cause any changes in the presence of H. pylori in oral cavity . Moreover no relationship was observed between the presence of H. pylori in oral cavity and the gastric H. pylori eradication . In line with these findings , no relationship between gastric and oral H. pylori was found using genetic profiling by r and om amplification of polymorphic DNA . Conclusions H. pylori was detected both in the oral cavity and the stomach but oral H. pylori had no relation to gastric H. pylori and remained unaffected by eradication of gastric H. pylori This study was design ed to compare differentprimer sets for PCR analysis of H. pylori in the sameseries of 40 dental plaque sample s. Three pairs ofprimers , HPU1/HPU2 , HP1/HP2 , and EHC-U/EHC-L , directed to the urease A gene , 16S rRNA gene , or 860-bpDNA of H. pylori , respectively , were used . Our results demonstrate that EHC-L/EHC-U were moRespecific and sensitive for H. pylori added to saliva or dental plaque than HPU1/HPU2 and HP1/HP2 . Thedetection rates for H. pylori DNA in dental plaque sample s from r and omly selected adult patients from theDental Clinic of the University of Ulm were 26.5 % ( 9/34 ) for HPU1/HPU2 , 78.9 % ( 30/38 ) for HP1/HP2 , and 100 % ( 40/40 ) for EHC-U/EHC-L ( P < 0.001 ) . Nested PCRusing primers directed to the 860-bp DNA of H. pylorifurThe r confirmed the presence of H. pylori DNA ( 40/40 ) in all these sample s. Our results indicate that primers EHC-U/EHC-L are to be recommendedfor PCR detection of H. pylori in the oralcavity BACKGROUND Two triple therapies with lansoprazole (LPZ)/amoxicillin (AMPC)/clarithromycin ( CAM ) for eradication of Helicobacter pylori were studied in multicenter , double-blind fashion to evaluate the eradication rate of H. pylori and safety of eradiation treatment in Japanese patients with H. pylori-positive active gastric ulcers or duodenal ulcers . METHODS Patients were r and omly chosen for the control treatment of LPZ 30 mg twice a day ( b.i.d . ; Group A-LPZ-only ) or the test treatments of LPZ 30 mg plus AMPC 750 mg and CAM 200 mg b.i.d . ( Group B-LAC200 ) and LPZ 30 mg , AMPC 750 mg and CAM 400 mg b.i.d . ( Group C-LAC400 ) . All eradication treatments lasted for a period of 7 days . Successful eradication was assessed by culture and gastric histology 1 month after completion of the ulcer treatment . RESULTS The eradication rates of H. pylori in the full analysis set were 0 % in Group A-LPZ-only , 87.5 % in Group B-LAC200 and 89.2 % in Group C-LAC400 for gastric ulcer and , 4.4 % in Group A-LPZ-only , 91.1 % in Group B-LAC200 and 83.7 % in Group C-LAC400 for duodenal ulcer . The eradication rates of Group B-LAC200 and Group C-LAC400 were 89.2 % ( 95 % CI : 84.8 - 93.7 % ) and 86.4 % ( 95%CI : 81.5 - 91.3 % ) in total in the full analysis set , 89 % ( 95 % CI : 84.3 - 93.7 % ) and 85.3 % ( 95%CI : 80.1 - 90.5 % ) in the per protocol set . The eradication rates in Groups B-LAC200 and group C-LAC400 were statistically significantly higher than the rate in Group A-LPZ-only for both gastric ulcer and duodenal ulcer patients ( p < .0001 for both ) . CONCLUSION A satisfactorily high H. pylori eradication rate was obtained in Japanese ulcer patients with the triple therapy regimen consisting of LPZ 30 mg , AMPC 750 mg , and CAM 200 mg b.i.d OBJECTIVE To determine whether antimicrobial therapy for Helicobacter pylori infection accelerates the healing of duodenal ulcers . DESIGN Single-blind , r and omized , controlled trial . SETTING Veterans Affairs hospital . PARTICIPANTS One hundred and five patients with endoscopically verified duodenal ulcers . INTERVENTION Patients received either ranitidine , 300 mg/d , or ranitidine , 300 mg/d , plus " triple therapy " ( 2 g/d of tetracycline , 750 mg/d of metronidazole , and 5 or 8 bismuth subsalicylate tablets per day ) . Triple therapy was administered for only the first 2 weeks of ulcer treatment . MEASUREMENTS Videoendoscopic assessment of ulcer status was done until ulcer healing was complete . Evaluations were done after 2 , 4 , 8 , 12 , and 16 weeks of therapy . MAIN RESULTS Ulcer healing was more rapid in patients receiving ranitidine plus triple therapy than in patients receiving ranitidine alone ( P less than 0.01 ) . The cumulative percentages of patients with healed ulcers in the group receiving ranitidine plus triple therapy and in the group receiving ranitidine alone were as follows : 37 % and 18 % after week 2 ; 74 % and 53 % after week 4 ; 84 % and 68 % after week 8 ; 96 % and 80 % after week 12 ; and 98 % and 84 % after week 16 . CONCLUSION Combined therapy with anti-H. pylori agents and ranitidine was superior to ranitidine alone for duodenal ulcer healing . Our results indicate that H. pylori plays a role in duodenal ulcer disease BACKGROUND The goal of this study was to see whether Helicobacter pylori ( H. pylori ) in the oral cavity might adversely affect the outcome of eradication therapy for gastric H. pylori . MATERIAL S AND METHODS Forty-seven patients ( 36 males , 11 females ) with gastric H. pylori infection were enrolled in this study . Gastric H. pylori infection was confirmed by both immunohistological staining with anti-H. pylori antibody and bacterial culture of biopsy specimens . The therapeutic regimen consisted of 30 mg/day lansoprazole , 750 mg/day metronidazole , and 400 mg/day clarithromycin administered for 2 weeks . A fragment of the H. pylori urease gene was amplified by nested PCR for DNA extracted from saliva and dental plaque from the same patients . We examined the correlation between the gastric eradication success rate and the prevalence of H. pylori in the oral cavity as determined by PCR before and after the eradication therapy . RESULTS The eradication success rate was significantly lower in the oral H. pylori-positive cases ( 12/23 , 52.1 % ) than in the negative cases ( 22/24 , 91.6 % ) at 4 weeks after the therapy ( p = . 0028 ) . Two years later , only 16 of the 23 ( 69.5 % ) oral H. pylori-positive cases were disease-free , as compared to 23 of the 24 ( 95.8 % ) oral H. pylori-negative cases ( p = .018 ) . CONCLUSIONS H. pylori in the oral cavity affected the outcome of eradication therapy and was associated with a recurrence of gastric infection . We recommend that oral H. pylori should be examined by nested PCR and , if positive , should be considered a causal factor in refractory or recurrent cases BACKGROUND Helicobacter pylori eradication from the oral cavity is more difficult than from the stomach . Thus , if the bacterium survives the antibacterial therapy in the oral cavity , it would be able to re-infect the stomach within a few weeks . Since oral health status could correspond to oral infection with H. pylori , the aim of the study was to determine whether oral health and oral hygiene practice s affect the efficacy of H. pylori eradication from the stomach . MATERIAL AND METHODS The study was performed in 137 patients with peptic ulcer who had undergone a 7-day course of eradication treatment with one of two sets of drugs : 1 , omeprazole , amoxicillin , and tinidazole or 2 , omeprazole , clarithromycin , and tinidazole .  The efficacy of H. pylori eradication from the stomach was evaluated at the second gastroscopy 4 weeks after cessation of eradication therapy by means of two methods : rapid urease test and histology . The examination of natural dentition and prosthetic restorations as well as the assessment of hygienic procedures referring to natural dentition and dentures accompanied the second gastroscopy . RESULTS No association was found between the efficacy of H. pylori eradication from the stomach and the number of natural teeth , decayed teeth , use of dentures , debris index , or periodontal index . However , an association between eradication success and some oral hygiene procedures were noted . Unexpectedly , in patients treated with omeprazole , amoxicillin and tinidazole , the removal of dental prosthesis for the night and brushing the natural teeth twice a day or more reduced the efficacy of H. pylori eradication from the stomach . CONCLUSIONS Oral health and oral hygiene practice s seem unlikely to increase the efficacy of H. pylori eradication from the stomach 
    Output:
    
In addition , periodontal therapy also had benefits on long-term gastric H. pylori eradication .
AUTHORS ' CONCLUSIONS Overall , periodontal therapy could increase the efficiency of H. pylori eradication and the non-recurrence rate of gastricH. pylori .