***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background Oral mucositis is one of the common complications of cancer chemotherapy and about 40 % of the patients who take chemotherapy protocol s , experience this irritating problem . The purpose of this study was to draw comparison between the therapeutic effects of our treatment modalities ( topical steroid , honey , honey plus coffee ) in patients suffering from oral mucositis . Methods This was a double blinded r and omised clinical trial of a total of 75 eligible adult participants which they r and omly fell into three treatment groups . For all the participants a syrup-like solution was prepared . Each 600 grams of the product consisted of “ 20 eight-mg Betamethasone solution ampoules ” in the Steroid ( S ) group , “ 300 grams of honey plus 20 grams of instant coffee ” in the Honey plus Coffee ( HC ) group , and “ 300 grams of honey ” for the Honey ( H ) group . The participants were told to sip 10 ml of the prescribed product , and then swallow it every three hours for one week . Severity of lesions was clinical ly evaluated before the treatment and also one week after the initiation of the intervention . This study adhered to the principles of the Declaration of Helsinki and guidelines of Good Clinical Practice . Results This study showed that all three treatment regimens reduce the severity of lesions . The best reduction in severity was achieved in HC group . H group and S group took the second and third places . In other words , honey plus coffee regimen was the most effective modality for the treatment of oral mucositis . Conclusion Oral mucositis can be successfully treated by a combination of honey and coffee as an alternative medicine in a short time . Further investigations are warranted in this field . Trial registration Iranian Registry of Clinical Trials I RCT : 201104074737N3 , ( 9 May 2011 ) Background : Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function . Propolis is a natural source of flavenoid which has antiulcer , antibacterial , antifungal , healing and anti-inflammatory effects . Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients . Objectives : Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer . Patients and Methods : In a r and omized triple blind clinical trial , 20 patient were selected r and omly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group ( n = 10 ) and 15 ml placebo mouth wash in control group ( n = 10 ) . we use NIC-CTC scale for determining mucositis grading . Results : We use T-test , Man-Whitney , Chi-square , and Friedman as analyzing tests . Case group had significantly ( P < 0.05 ) lower grade of mucositis in all of the follow-ups , but xerostomia is not significantly different in two groups ( P > 0.05 ) . Conclusions : This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis One of the most common complications of cancer chemotherapy is oral mucositis . This study evaluates the therapeutic effects of honey with the focus on grade III and IV oral mucositis , reduction of bacterial and fungal infections , duration of episodes of oral mucositis , and body weight in pediatric leukemic patients undergoing chemo/radiotherapy . This is an open labeled r and omized controlled study conducted at our hospital on 40 pediatric cancer patients undergoing chemo/radiotherapy .  All the 40 patients included in this study experienced a sum total of 390 episodes of fever and neutropenia associated with oral mucositis . A significant reduction of oral mucositis , associated C and ida , and aerobic pathogenic bacterial infections was noted in patients in the honey treatment group . Also , there is a significant decrease in the duration of hospitalization for all those in the treatment group combined with a significant increase of body weight , delayed onset , and decreased severity of pain related to oral mucositis . Complications of oral mucositis can be tremendously reduced by the topical application of local Saudi honey and honey should be used as an integrative approach in prophylaxis and treatment of chemo/radiotherapy-induced oral mucositis in pediatric cancer patients . Further research is needed to eluci date and better underst and the underlying mechanism A study was conducted to analyze the effects of propolis mouth rinse on the repair of surgical wounds after sulcoplasty by the modified Kazanjian technique . Twenty-seven patients who underwent sulcoplasty were divided into three groups : C1 - - patients who did not use the mouth rinse C2 - - patients who used a mouth rinse containing 5 % aqueous alcohol T-- patients who used a mouth rinse containing 5 % propolis in aqueous alcohol solution .  The patients returned 7 , 14 , 30 , and 45 days after surgery for cytological and clinical evaluation . It was concluded that : 1 ) the mouth rinse containing propolis in aqueous alcohol solution aids repair of intra-buccal surgical wounds and exerts a small pain-killing and anti-inflammatory effect ; 2 ) the vehicle employed has a minor irritant effect on intra-buccal surgical wounds ; 3 ) exfoliative cytology allows epithelization of intrabuccal surgical wounds The objective of this phase II study was to determine the effectiveness of a mucoadhesive propolis gel in the prevention of radiation-induced oral mucositis . Twenty-four patients who were selected to undergo radiation therapy for oral cancer were included in this open-label trial . They were advised to use a mucoadhesive gel containing propolis 5,0 % w/v three times a day starting one day before the course of radiation therapy and concluding after 2 weeks of radiation therapy . A weekly follow-up for evaluation of food intake , pain and grading of mucositis was performed . In order to confirm the absence of C and ida-related mucositis in patients who developed mucositis , it was performed exfoliative cytology of buccal mucosa , palate and tongue and the material for C and ifast ( ® ) C and ida species identification . At the end of the study was made the compliance of patients , quality , appreciation and acceptance of product evaluation . Twenty patients did not develop mucositis , two patients developed grade 1 mucositis and two patients developed grade 2 mucositis . None of the patients discontinued food intake and no pain was observed during the study . C and idosis was not detected in any patient . Mucoadhesive propolis gel could be considered as a potential topical medication for preventing radiation-induced oral mucositis . However , comparative phase III study with larger number of patients should be done for confirmation of the efficacy of the product OBJECTIVES Chemotherapy-induced oral mucositis ( OM ) is a debilitating side effect . In addition to st and ard therapy , patients often use complementary and alternative medicine to treat OM . DESIGN Double blind r and omised placebo controlled study assessing propolis ( bee glue ) efficacy for chemotherapy-induced severe OM treatment . SETTING University Children 's Hospital , University Medical Centre Ljubljana , Ljubljana , Slovenia . INTERVENTIONS Paediatric patients undergoing chemotherapy  were r and omly assigned to  propolis ( n=19 ) or placebo groups ( n=21 ) . Patients were introduced to a unified oral care protocol and asked to apply propolis or placebo to vestibular mucosa twice daily . Oral mucosa was assessed with the Oral Assessment Guide ( OAG ) twice a week when the patients were in hospital . Patients were followed for the period of the chemotherapy or for the first 6 months of the chemotherapy . An OAG score of 3 was considered to be severe OM and analysed . MAIN OUTCOME MEASUREMENTS Three dependent variables ( a ) OM episode frequency , ( b ) mean number of assessment visits , at which an OAG 3 score was noted , expressing mean OM duration , ( c ) mean number of OAG 3 scores expressing mean OM severity ) were reduced to a single variable using principal component analysis . A new variable ( FDS ) was used as the dependent variable in ANCOVA model analysis to show the differences between study groups . RESULTS Severe OM was seen in 42 % and 48 % of patients in the propolis and placebo group , respectively . FDS was not statistically significant between study groups ( p=0.59 ) . CONCLUSIONS According to our study results , propolis can not be recommended for severe OM treatment BACKGROUND R and omized controlled trials ( RCTs ) in surgery can provide valuable evidence of the efficacy of interventions if they are well- design ed , appropriately executed , and adequately reported . Adequate reporting of methodology in surgical RCTs is known to be poor , and adverse-event reporting in surgical research is inconsistent . The Consoli date d St and ards of Reporting Trials ( CONSORT ) statement is a framework to help authors report their findings in a transparent manner . Extensions to the CONSORT statement have been published recently to address deficiencies in adverse-event reporting and in reporting of specific criteria related to nonpharmacologic treatments . The aim of this study was to assess the quality of reporting of trial methodology and adverse events in a sample of general surgical RCTs published in high- quality surgical journals using the criteria specified in the CONSORT statements . STUDY DESIGN We used impact factor to identify the top three ranked surgical journals in 2004 . We then obtained information on all RCTs published in these journals in the 2005 calendar year . We assessed quality of reporting using Jadad score , compared the quality of RCTs from CONSORT-endorsing journals with nonendorsers , and assessed the number of RCTs adequately reporting key generic method ologic , adverse-event-related , and specific nonpharmacologic criteria . RESULTS Of 42 RCTs analyzed , only 40 % ( 17 of 42 ) had a Jadad score > or = 3 . There was no significant difference in the number of high- quality RCTs published in CONSORT-endorsing journals compared with nonendorsers ( p = 0.3 ) . The median percentage of RCTs adequately reporting generic method ologic , adverse-event-related , and specific nonpharmacologic criteria was 32.5 % , 17 % , and 36.5 % , respectively . CONCLUSIONS Quality of reporting of generic method ologic , adverse-event-related , and specific nonpharmacologic criteria in surgical RCTs is poor . Increased attention to quality of reporting of surgical RCTs is required if studies are to meet published criteria 
    Output:
    
No side effects were reported .
Conclusions Propolis mouthwash  is effective and safe in the treatment of severe oral mucositis .