***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: This study presents the results of a cost-effectiveness analysis in a controlled clinical trial on the effectiveness of a modified glass ionomer resin sealant ( Vitremer , 3 M ESPE ) and the application of fluoride varnish ( Duraphat , Colgate ) on occlusal surfaces of first permanent molars in children 6 - 8 years of age ( N = 268 ) , according to caries risk ( high versus low ) . Children were examined semiannually by the same calibrated dentist for 24 months after allocation in six groups : high and low risk controls ( oral health education every three months ) ; high and low risk with varnish ( oral health education every three months + varnish biannually ) ; and high and low risk with sealant ( oral health education every three months + a single application of sealant ) . Economic analysis showed that sealing permanent first molars of high-risk schoolchildren showed a C/E ratio of US$ 119.80 per saved occlusal surface and an incremental C/E ratio of US$ 108.36 per additional saved occlusal surface . The study concluded that sealing permanent first molars of high-risk schoolchildren was the most cost-effective intervention Sealants and xylitol have been demonstrated to prevent  dental decay  , but their effect has never been compared in the same study . Regular use of xylitol chewing gum during 2 or 3 school years was compared with application of occlusal sealants in a r and omized study . The reliability of the clinical observations was controlled by examining the presence of dental decay in the same teeth from bitewing radiographs in a blind study . After 5 years , no statistically significant differences between the sealant and xylitol groups were found . The results were in line with the results from separate studies with sealants or xylitol . There were no great differences between the costs of the measures . The selection between the compared preventive measures has to be made on the basis of practical aspects such as caries occurrence , availability of personnel and other re sources , opportunity costs , cooperation with schools , and other local conditions 
    Output:
    
Recent evidence indicates the benefits of SSPs exceed their costs when SSPs target schools attended by a large number of high-risk children