***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: BACKGROUND Activating somatic mutations in the promoter region of the telomerase reverse transcriptase gene ( TERT ) have been detected in several cancers . In this study we investigated the TERT promoter mutations and their impact on  patient survival in World Health Organization grade IV glioblastoma multiforme ( GBM ) . METHODS The TERT core promoter region containing the previously described mutations and a common functional polymorphism ( rs2853669 ) was sequenced in tumors and blood sample s from 192 GBM patients . O(6)-methylguanine-DNA methyltransferase ( MGMT ) promoter methylation status was assessed by pyrosequencing in 177 ( 92.2 % ) cases . Relevant clinical data were obtained from a prospect ively maintained electronic data base . RESULTS We detected specific ( -124 C > T and -146 C > T ) TERT promoter mutations in 143/178 ( 80.3 % ) primary GBM and 4/14 ( 28.6 % ) secondary GBM ( P < .001 ) . The presence of TERT mutations was associated with poor overall survival , and the effect was confined to the patients who did not carry the variant G-allele for the rs2853669 polymorphism . An exploratory analysis suggested that TERT mutations might be prognostic only in patients who had incomplete resections and no temozolomide chemotherapy . CONCLUSIONS In this study , specific TERT promoter mutations were markers of primary GBM and predicted patient survival in conjunction with a common functional polymorphism . The prognostic impact of TERT mutations was absent in patients with complete resections and temozolomide chemotherapy . If confirmed in additional studies , these findings may have clinical implication s , that is , TERT mutations appear to characterize tumors that require aggressive treatment AIM Colorectal cancer is the third most common cause of cancer-related mortality . Previous studies demonstrated increased telomerase activity in colorectal cancer tissue and suggested a prognostic value for patients with colorectal carcinoma .  Telomerase reverse transcriptase ( TERT ) , one of the main functional subunits of the telomerase , is an important factor in modulating telomerase activity , telomere length , and genomic stability . However , there are few studies that have addressed the association between genetic variation at TERT and the risk of colorectal cancer . METHOD We evaluated the influence of three common single-nucleotide polymorphisms ( SNPs ) of the TERT gene ( rs2853669 , rs2736100 , rs2736098 ) on  susceptibility to colorectal cancer in 104 patients and 135 controls in a Turkish population . RESULTS We observed that rs2736098 was significantly associated with increased risk of colorectal cancer ( OR = 2.53 ; 95 % CI = 1.26 - 5.10 ; p = 0.008 ) . On the other h and , rs2736100 and rs2853669 showed no association with colorectal cancer ( p ≥ 0.128 ) . CONCLUSION These findings are the first results of TERT allele distributions in the Turkish population and also provide increased underst and ing with respect to colorectal cancer etiology 
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Subsequent analyses also did not reveal any association between rs2853669 and overall cancer prognosis .
In conclusion , our findings suggest that rs2853669 could be important for assessing the prognostic value of TERTp mutations .