***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: ABSTRACT This study was design ed to assess the efficacy and tolerability of MAS065D ( Xclair ™ ) compared to a vehicle control in the management of  radiation dermatitis in patients receiving radiotherapy for breast cancer . Twenty patients were r and omized blindly to use the two study substances , three times daily , on separate sections of irradiated skin throughout the duration of radiotherapy and for two weeks afterwards . Patients were monitored before therapy , weekly during therapy , and for 2 weeks after radiotherapy was completed . Skin appearance according to National Cancer Institute ( NCI ) toxicity criteria , erythema rating , transepidermal water loss ( TEWL ) , skin hydration , patients ' view of itch , pain , acceptance , and view of each cream and adverse events , were monitored ; at the final visit patients and investigators expressed their preference for one of the creams . MAS065D showed statistically significant superiority in the outcomes of NCI grading for radiation dermatitis and erythema . Patients ' and investigators ' preferences for one of the study substances were statistically in favor of MAS065D . Very few patients recorded nonzero itch and pain scales , so no significant differences emerged between the two groups . It was concluded that MAS065D can provide an effective option for managing radiation dermatitis although further studies are needed to assess its effect on pain and itch Objective : To determine if a hyaluronic acid/carboxymethylcellulose ( HA/CMC ) sinus dressing reduces the rate of postoperative scarring . Methods : In a r and omized , matched-controlled , single-blinded study , following the completion of surgery , an HA/CMC dressing was r and omly assigned to one side with the opposite unpacked side serving as a control . Results : Fifty-three patients underwent surgery for chronic rhinosinusitis ( CRS ; 39 patients ) or CRS with nasal polyposis ( 14 patients ) . At the 8-week follow-up , there was no difference in synechiae on the HA/CMC side compared to the control ( p = 0.09 ) . HA/CMC-treated sinuses , however , demonstrated fewer synechiae in the first 2 weeks postoperatively compared to the control ( p = 0.01 ) , and were associated with significantly less nasal congestion at the 4-week ( p = 0.02 ) and 8-week follow-up visits ( 0.03 ) . Conclusion : There was no long-term difference in the rate of synechiae in the HA/CMC-treated sinus compared to the control . However , less severe nasal congestion and synechiae in the initial postoperative period may reduce the need for aggressive sinus debridement The purpose of this study was to evaluate outcomes of persons with neuropathic diabetic foot wounds treated with a hyaluronan-containing dressing . Data were abstract ed for 36 patients with diabetes , 72.2 % male , aged 60.0+/-10.7 years and a mean glycated hemoglobin ( HbA(1c ) ) of 9.5+/-2.5 % presenting for care at two large , multidisciplinary wound care centers . All patients received surgical debridement for their diabetic foot wounds and were placed on therapy consisting of hyaluronan dressing ( Hyalofill , Convatec , USA ) with dressing changes taking place every other day . Outcomes evaluated included time to complete wound closure and proportion of patients achieving wound closure in 20 weeks . Hyalofill therapy was used until the wound bed achieved 100 % granulation tissue . Therapy was then followed by a moisture-retentive dressing until complete epithelialization . In total , 75.0 % of wounds measuring a mean 2.2+/-2.2 cm(2 ) healed in the 20-week evaluation period . Of those that healed in this period , healing took place in a mean 10.0+/-4.8 weeks . The average duration of Hyalofill therapy  in all patients was 8.6+/-4.2 weeks . Deeper ( UT Grade 2A ) wounds were over 15 times less likely to heal than superficial ( 1A ) wounds ( 94.7 vs. 52.9 % , Odds Ratio=15.9 , 95 % Confidence Interval=1.7 - 142.8 , P=0.006 ) . We conclude that a regimen consisting of moist wound healing using hyaluronan-containing dressings may be a useful adjunct to appropriate diabetic foot ulcer care . We await the completion of a multicenter r and omized controlled trial in this area to either support or refute this initial assessment Neuropathic  leg ulcers ( NLUs ) affect more than 10 % of diabetic patients with peripheral neuropathy and represent the most common cause of ulceration of the leg in these patients . Though their pathogenesis is well known , related to the chronic neuropathic edema , the management of NLUs , mainly based on elastocompression , is still controversial , with lower healing rates than nondiabetic venous leg ulcers . The authors tested if a novel gel formulation , containing amino acids and hyaluronic acid ( Vulnamin ® gel ; Errekappa , Milan , Italy ) , will improve the outcomes of NLUs when used together with elastocompression . Thirty patients affected by NLU were r and omized into 2 groups , both treated with 4-layer elastocompressive b and aging : patients in group A were topically treated with the application of Vulnamin ® gel , whereas patients in group B received only the inert gel vehicle .  The healing rate at 3 months was evaluated as the primary endpoint , whereas the secondary endpoints were healing time , reduction in ulcer area and ulceration score in 4 weeks , number of infective complications , and overall satisfaction of patients . Healing rate was significantly ( P < .05 ) higher in patients in group A when compared with those in group B ; healing time , patients ’ satisfaction , and reduction in ulcer area and ulceration score in 4 weeks were also higher in patients in group A. However , no significant differences were found in the prevalence of infections and other adverse events . The use of Vulnamin ® gel with elastocompression is safe and effective in the management of NLUs of diabetic patients BACKGROUND The aim of this study was to evaluate the efficacy of a topical hyaluronic acid ( HA ) gel preparation ( 0.2 % ) in the management of oral lichen planus ( OLP ) . METHODS A total of 124 patients with erosive OLP participated in a r and omized , placebo-controlled , double-blind trial to evaluate the efficacy of a topical HA preparation . Outcome measures included soreness relief following immediate application , oral function and size of erosive/ulcerative area . Patients were medicated for 28 days and completed a log diary recording oral function and soreness scores . RESULTS Application of topical HA produced a significant reduction ( P < 0.05 ) in soreness scores when compared with placebo for up to 4 h post-application . There was no difference between treatment groups ( P > 0.05 ) with respect to oral function . Patients treated with 0.2 % HA showed a significant reduction ( P < 0.05 ) in the size of the erosive/ulcerated area after 28 days of treatment when compared with baseline . There was no significant difference in changes in ulcerative areas between treatment groups . CONCLUSIONS Topical HA ( 0.2 % ) does appear to be of some benefit in the management of erosive lichen planus providing efficacy for up to 4 h after administration . Very frequent applications should be considered to obtain a more significant clinical benefit . Topical HA gel may be a useful addition to the treatment option for OLP Prior studies have suggested that hyaluronic acid ( HA ) , a naturally occurring glycosaminoglycan , may accelerate the healing of superficial burn wounds . To objective ly assess whether exogenous HA could accelerate the rate of healing and limit scar formation in superficial wounds , 11 patients with burn injuries who were undergoing skin grafting were given two separate skin graft donor sites of similar size and depth ( 1 " x 1 " x 0.016 " ) . In a r and omized , double-blind fashion , one of these partial-thickness wounds had repeated application with 1.5 % HA ; 100 % glycerin , which served as a control of similar viscosity , was applied to the other wound . On alternating days , photographs were taken and then analyzed with computerized digital planimetry to objective ly quantitate the rate of reepithelialization . In contrary to our hypothesis , HA significantly delayed wound healing compared to the glycerin control ( time to > 95 % reepithelialization : 10.3 + /- 2 days HA vs. 9.1 + /- 1.6 days control ; mean + /- SD ) . Furthermore , no difference in the result ant scar at 6 weeks and at 3 months after wounding was evident . These results demonstrate that HA retards healing of partial thickness wounds in adults OBJECTIVE To evaluate the clinical efficacy and safety of HYAFF 11-based autologous dermal and epidermal grafts in the management of diabetic foot ulcers . RESEARCH DESIGN AND METHODS A total of 79 patients with diabetic dorsal ( n = 37 ) or plantar ( n = 42 ) ulcers were r and omized to either the control group with nonadherent paraffin gauze ( n = 36 ) or the treatment group with autologous tissue-engineered grafts ( n = 43 ) . Weekly assessment , aggressive debridement , wound infection control , and adequate pressure relief ( fiberglass off-loading cast for plantar ulcers ) were provided in both groups . Complete wound healing was assessed within 11 weeks . Safety was monitored by adverse events . RESULTS Complete ulcer healing was achieved in 65.3 % of the treatment group and 49.6 % of the control group ( P = 0.191 ) . The Kaplan-Meier mean time to closure was 57 and 77 days , respectively , for the treatment versus control groups . Plantar foot ulcer healing was 55 % and 50 % in the treatment and control groups , respectively . Dorsal foot ulcer healing was significantly different , with 67 % in the treatment group and 31 % in the control group ( P = 0.049 ) . The mean healing time in the dorsal treatment group was 63 days , and the odds ratio for dorsal ulcer healing compared with the control group was 4.44 ( P = 0.037 ) . Adverse events were equally distributed between the two groups , and none were related to the treatments . CONCLUSIONS The autologous tissue-engineered treatment exhibited improved healing in dorsal ulcers when compared with the current st and ard dressing . For plantar ulcers , the off-loading cast was presumably paramount and masked or nullified the effects of the autologous wound treatment . This treatment , however , may be useful in patients for whom the total off-loading cast is not recommended and only a less effective off-loading device can be applied Intra-articular injections of hyaluronic acid products may eliminate pain , improve mobility and quality of life , and delay osteoarthritis progression . In this study , we evaluated the safety and efficacy of sodium hyaluronate injections given after knee arthroscopy . Forty-six patients with early osteoarthritis and a symptomatic meniscus tear were prospect ively r and omized into study ( injection ) and control groups and underwent knee arthroscopy . Study patients received 3 sodium hyaluronate injections after surgery . Study and control outcomes were compared 3 and 6 months after surgery . The injection patients had significantly less pain ( visual analog scale ) at 3-month follow-up and more flexion at 6-month follow-up . Tenderness , pain on motion , and crepitus were significantly more likely to be absent from injection patients at the 3- and 6-month follow-ups . Patients with osteoarthritis and a symptomatic meniscus tear may experience more pain relief and functional mobility after arthroscopic surgery plus hyaluronic acid injections than after arthroscopy alone This study evaluated the efficacy and tolerability of an autologous tissue-engineered graft — a 2-step HYAFF autograft — in the treatment of diabetic foot ulcers compared with st and ard care . In all , 180 patients with dorsal or plantar diabetic foot ulcers ( unhealed for ≥1 month ) were r and omized to receive Hyalograft-3D autograft first and then Laserskin autograft after 2 weeks ( n = 90 ; treatment group ) or nonadherent paraffin gauze ( n = 90 ; control group ) . Efficacy and adverse events were assessed weekly for 12 weeks , at 20 weeks , and at 18 months . The primary efficacy outcome was complete ulcer healing at 12 weeks . Wound debridement , adequate pressure relief , and infection control were provided to both groups . At 12 weeks , complete ulcer healing was similar in both groups ( 24 % of treated vs 21 % controls ) . A 50 % reduction in ulcer area was achieved significantly faster in the treatment group ( mean 40 vs 50 days ; P = .018 ) . Weekly percentage ulcer reduction was consistently higher in the treatment group . At 20 weeks , ulcer healing was achieved in 50 % of the treated group as compared with 43 % of controls . Dorsal ulcers had a 2.17-fold better chance of wound healing per unit time following autograft treatment ( P = .047 ) . In a subgroup with hard-to-heal ulcers , there was a 3.65-fold better chance of wound healing following autograft treatment of dorsal ulcers ( P = .035 ) . Adverse events were similar in both groups . The 
    Output:
    
Further , it was found in a meta- analysis in subsets of patients with diabetic foot ulcers ( neuropathic ) that HA derivatives  healed these types of wounds significantly faster than st and ard of care .
These studies in aggregate show that HA derivatives accelerate the healing process in burns , epithelial surgical wounds , and chronic wounds