***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: CONTEXT In anthroposophical medicine , total extracts of Viscum album ( mistletoe ) have been developed to treat cancer patients . The oldest such product is Iscador . Although Iscador is regarded as a complementary cancer therapy , it is the most commonly used oncological drug in Germany . OBJECTIVE To determine whether Iscador treatment prolongs survival time of patients with carcinoma of the colon , rectum , or stomach ; breast carcinoma with or without axillary or remote metastases ; or small cell or non-small-cell bronchogenic carcinoma ; and to explore synergies between Iscador treatment and psychosomatic self-regulation . DESIGN Prospect i ve nonr and omized and r and omized matched-pair studies nested within a cohort study . SETTING General community in Germany . PARTICIPANTS 10,226 cancer patients involved in a prospect i ve long-term epidemiological cohort study , including 1668 patients treated with Iscador and 8475 who had taken neither Iscador nor any other mistletoe product ( control patients ) . INTERVENTION Iscador . MAIN OUTCOME MEASURE Survival time . RESULTS In the nonr and omized matched-pair study , survival time of patients treated with Iscador was longer for all types of cancer studied . In the pool of 396 matched pairs , mean survival time in the Iscador groups ( 4.23 years ) was roughly 40 % longer than in the control groups ( 3.05 years ; P < .001 ) . Synergies between Iscador treatment and self-regulation manifested in a longer survival advantage for Iscador patients with good self-regulation ( 56 % relative to control group ; P = .03 ) than for patients with poor self-regulation . Results of the 2 r and omized matched-pair studies largely confirmed the results of the non-r and omized studies . CONCLUSION Iscador treatment can achieve a clinical ly relevant prolongation of survival time of cancer patients and appears to stimulate self-regulation BACKGROUND Anthroposophical Therapeutic Speech uses poems and exercises which typically induce rhythmical breathing . Speaking influences respiration and thus directly heart rate variability ( HRV ) , in particular via respiratory sinus arrhythmia which , together with the slower rhythms of HRV , may be regarded as an indicator of sympathovagal balance . In chronomedicine numerous frequency ratios between physiological rhythms , especially in trophotropic phases , have been established . Integer ratios occur frequently and seem to be associated with the optimization of physiological processes . In larger groups the average pulse respiration quotient is about 4:1 . QUESTION Can systematic effects on HRV , and thus on autonomic balance , be established through special speech therapy ? SUBJECTS AND METHODS In two trained therapists and 7 untrained subjects the influence of different speech exercises and texts on HRV was investigated . With untrained subjects a total of 105 one-hour sessions , divided into speech and control exercises , was performed . The overall well-being and quality of well-being were assessed with question naires . Control evaluations were made in the same setting . RESULTS As a simultaneous effect , during speech exercises and texts typical intra- and inter-individually reproducible patterns in heart rate variability were observed . Reciting poems with a hexameter metric generates 2 oscillations with a 2:1 frequency ratio in the HRV spectrum . As immediate effects there were a significant drop in heart rate after speech sessions as well as a strengthening of vagus-related HRV parameters , especially after hexameter exercises . In comparison to control sessions the subjects felt significantly better , too . The different metric and poetic character of the texts was reflected clearly in the results This review assesses the evidence of the efficacy of mistletoe extracts in cancer patients from controlled clinical trials in humans . We used a list of predefined criteria for good methodology to select the trials which had the highest quality and interpreted the results with emphasis on the quality . An extensive search of the literature yielded 11 controlled trials in which at least an attempt was made for unbiased allocation into the contrasted treatment groups . The average quality of the trials appeared to be disappointingly poor . It concerned trials for bronchus carcinoma , colorectal carcinoma , mamma carcinoma , gastric cancer and female genital cancer . In the trials the results were in favour of mistletoe treatment ; the principle endpoint was mostly survival time . Only one trial could not show a beneficial effect , but this was the trial with the highest method ological score . Well performed r and omized , double-blind clinical trials on carefully chosen patient population s are needed in order to make assessment s of any efficacy . Further evidence should also consist of a more solid demonstration of the mechanisms of action from laboratory studies . St and ardization methods on active substances should be improved as there are apparent component variations between , but also within the preparations which were used in clinical trials . Considering the state of affairs we can not recommend the use of mistletoe extracts in the treatment of cancer patients with an exception for patients involved in clinical trials CONTEXT The human organism has the inherent ability to regulate and coordinate physiological functions to establish well-being . If this ability is disturbed , eg , in cases of orthostatic syndrome with purely functional disorders , an herbal remedy based on anthroposophical medicine may be able to regulate such rhythmic disturbances . OBJECTIVE To determine the effect of the anthroposophical herbal remedy on stimulating the ability to regulate and coordinate physiological functions in healthy subjects . DESIGN Double-blind , placebo-controlled , r and omized trial PARTICIPANTS Ninety-nine healthy subjects ; 49 received the remedy , 50 received the placebo .  INTERVENTION Oral administration of the remedy for 4 weeks , 20 drops 4 times daily . MAIN OUTCOME MEASURES Cardiorespiratory interaction was analyzed by 2 measures : the heart-respiratory ratio and the phase-coordination ratio of heartbeat and respiration . They were calculated from heart rate and respiratory rate , which were derived from 24-hour electrocardiogram recordings before and after the administration of the remedy . Improved normalization of these measures during nighttime sleep after administration of the remedy indicates a stimulation of regulation . RESULTS Oral administration of the remedy result ed in an improved normalization of heart-respiratory ratio , phase-coordination ratio and heart rate during nighttime sleep . These results were not observed in the placebo group . CONCLUSIONS The remedy stimulates the regulation of cardiorespiratory interaction during nighttime sleep . Furthermore , improved normalization indicates a general improvement of the regulatory processes of functional rhythms 
    Output:
    
It was therefore concluded that , at present , the question whether the anthroposophical concept of healing generates more good than harm can not be answered