***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: The effect of soft-laser application on postoperative pain and swelling was evaluated in a double-blind , crossover study . Twenty-five healthy adults with bilateral identically impacted lower third molars were selected for this study . The teeth were removed in two separate operations . Laser treatment was tested in comparison with placebo laser , with a 40-mW , 830-nm Biophoton laser ( Roenvig Dental , Denmark ) . All surgical procedures and measurements were done by the same surgeon . The following features were statistically analyzed : swelling , trismus , and subjective registration of pain on a visual analog scale . No statistically significant differences were observed in comparison of the experimental side with the placebo side . It may be concluded that soft-laser treatment has no beneficial effect on swelling , trismus , and pain after third molar surgery The pain experienced after  116 operative removals of  m and ibular third molars was studied in a homogeneous group of patients consisting of 85 healthy university students .  Pain was recorded daily on a visual analogue scale during the postoperative week . It was shown that preoperative inflammation and the difficulty and duration of the operation increased the intensity of pain Our aim was to compare the use of a conventional rotary h and piece and a Piezosurgical unit for extraction of lower third molars . We studied 40 patients , who were allocated alternately to have the third molar removed with either the h and piece or the Piezosurgical unit .  Pain , trismus , and oedema were evaluated at baseline and then postoperatively , together with paraesthesiae , on postoperative days 1 , 3 , 5 , 7 , and 15 . Damage to surrounding tissue was checked on the same day whereas dry socket was evaluated from postoperative day 3 onwards . More patients complained of pain in the conventional group , they also required more analgesics , and they developed trismus more often than in the Piezosurgery group . There was also significantly more postoperative swelling in the conventional group . Patients were also evaluated using the subjective Postoperative Symptom Severity ( PoSSe ) scale . Our results suggest that apart from some inherent limitations with the Piezotome , it is a valuable alternative for extraction of third molars A r and omised , double blind comparative study was undertaken to assess the efficacy of low level laser therapy in the reduction of postoperative pain and swelling in patients undergoing the extraction of bilaterally impacted m and ibular third molar teeth .  Healing of the sockets was also compared after 1 week . A group of 64 patients had one r and omly-selected operation side treated with a semi-conductor laser and the other side with an apparently identical but non-operating model . Complete data were obtained from 52 of the 64 patients . The results showed that there was no evidence of a difference in pain and swelling on the third day after operation between laser and placebo sides . There was no difference between the two sides when they were assessed for healing 7 days after surgery The aim of the study was to evaluate the effect of low level laser application on postoperative pain after endodontic surgery in a double blind , r and omized clinical study . Fifty-two healthy adults undergoing endodontic surgery were included into the study . Subsequently to suturing , 26 patients had the operation site treated with an 809 nm-GaAlAs-laser ( oralaser voxx , Oralia GmbH , Konstanz , Germany ) at a power output of 50 mW and an irradiation time of 150 s. Laser treatment was simulated in further 26 patients . Patients were instructed to evaluate their postoperative pain on 7 days after surgery by means of a visual analogue scale ( VAS ) . The results revealed that the pain level in the laser group was lower than in the placebo group throughout the 7 day follow-up period . The differences , however , were significant only on the first postoperative day ( Mann-Whitney U-test , p<0.05 ) . Low level laser therapy can be beneficial for the reduction of postoperative pain . Its clinical efficiency and applicability with regard to endodontic surgery , however require further investigation . This is in particular true for the optimal energy dosage and the number of laser treatments needed after surgery OBJECTIVE The purpose of this study was to evaluate the effect of low-level laser therapy ( LLLT ) on postoperative trismus and edema after the removal of m and ibular third molars . MATERIAL S AND METHODS Thirty-two patients who were to undergo surgical removal of lower third molars were studied . Patients were r and omly allocated to two groups , LLLT and placebo . Patients in the LLLT group received 12 J ( 4 J/cm(2 ) ) low-level laser irradiation to the operative side intraorally 1 cm from the target tissue , and to the masseter muscle extraorally immediately after surgery . In the placebo group the h and piece was inserted into the operative side intraorally and was applied to the masseter muscle extraorally each for 1 min , but laser power was not activated . Inter-incisal opening and facial swelling were evaluated on postoperative days 2 and 7 . Student 's t-test used to analyze the data . RESULTS It was determined that the trismus and the swelling in LLLT group were significantly less than in the placebo group on postoperative days 2 and 7 . CONCLUSION Within the limitations of this study it can be concluded that LLLT can be beneficial for the reduction of postoperative trismus and swelling after third molar surgery This study aims to evaluate the efficacy of the ozone and laser application in the management of pain , swelling , and trismus after third-molar surgery . Sixty consecutive patients with asymptomatic impacted m and ibular third molars were recruited into the study . Patients were r and omized into three treatment groups of 20 patients each : two study groups ( group 1 = low-level laser therapy ( LLLT ) , group 2 = ozone therapy ) and a control group ( no-LLLT or ozone therapy ) . Twenty teeth extraction s were performed in each group . Evaluations of postoperative pain , the number of analgesics tablets taken , trismus , swelling , and quality of life ( Oral Health Impact Profile-14 question naire ) were made . The sample consisted of 28 female and 32 male patients , whose total mean age was 23.5 ± 3.4 ( range , 18–25 ) years .  The pain level and the number of analgesics tablets taken were lower in the ozonated and LLLT applied groups than in the control group . This study showed that ozone and low power laser therapies had a positive effect on the patients ’ quality of life . Trismus in the LLLT group was significantly less than in the ozonated and control groups ( p = 0.033 ) . Ozone application showed no superiority in regards of postoperative swelling ; however , LLLT group had significantly lower postoperative swelling . This study demonstrates that ozone and laser therapies are useful for the reduction of postoperative pain and they increase quality of life after third-molar surgery . Although the ozone therapy had no effect on postoperative swelling and trismus after surgical removal of impacted lower third molars , LLLT had a positive effect The aim of this study is to compare the effectiveness of low-level laser irradiation to traditional topical fluoride treatment for treatment choices of dentinal hypersensitivity following scaling and root planing . The experimental group ( 15 patients ) was treated with low-energy-level diode laser at each site of dentinal hypersensitivity following scaling and root planning . The control group ( 15 patients ) received topical fluoride treatment ( protective varnish for desensitization ) . All the patients were treated at baseline visit , and then at day 2 and 4 after the initial treatment ; the pain was subjectively assessed by the patients as strong , medium , medium low , low , or no pain . Total absence of the dental hypersensitivity was reported in 26.66 % of the examined group even after the second visit , compared to the control group where complete resolution of the hypersensitivity was not present after the second visit in any of the treated cases . Complete absence of pain was achieved in 86.6 % of patients treated with laser and only in 26.6 % in the fluoride treated group , after the third visit . Based on our findings , we conclude that low-energy biostimulative laser treatment can be successfully used for treatment of dental hypersensitivity following scaling and root planing Low-level laser therapy ( LLLT ) has been found to produce anti-inflammatory effects in a variety of disorders . Tendinopathies are directly related to unbalance in expression of pro- and anti-inflammatory cytokines which are responsible by degeneration process of tendinocytes . In the current study , we decided to investigate if LLLT could reduce mRNA expression for TNF-α , IL-1β , IL-6 , TGF-β cytokines , and COX-2 enzyme . Forty-two male Wistar rats were divided r and omly in seven groups , and tendinitis was induced with a collagenase intratendinea injection . The mRNA expression was evaluated by real-time PCR in 7th and 14th days after tendinitis . LLLT irradiation with wavelength of 780 nm required for 75 s with a dose of 7.7 J/cm2 was administered in distinct moments : 12 h and 7 days post tendinitis . At the 12 h after tendinitis , the animals were irradiated once in intercalate days until the 7th or 14th day in and them the animals were killed , respectively . In other series , 7 days after tendinitis , the animals were irradiated once in intercalated days until the 14th day and then the animals were killed . LLLT in both acute and chronic phases decreased IL-6 , COX-2 , and TGF-β expression after tendinitis , respectively , when compared to tendinitis groups : IL-6 , COX-2 , and TGF-β . The LLLT  not altered IL-1β expression in any time , but reduced the TNF-α expression ; however , only at chronic phase . We conclude that LLLT administered with this protocol reduces one of features of tendinopathies that is mRNA expression for pro-inflammatory mediators The aim of this study is to evaluate the effectiveness of the low-level laser therapy ( LLLT ) in the control of pain , swelling , and trismus associated with surgical removal of impacted lower third molars . Thirty patients were r and omized into two treatment groups , each with 15 patients —group test ( LLLT ) and a group control (no-LLLT)— and were told to avoid any analgesics 12 h before the procedure . In group test , the 980-nm diode-laser ( G-Laser 25 Galbiati , Italy ) was applied , using a 600-μm h and piece , intraorally ( lingual and vestibular ) at 1 cm from the involved area and extraoral at the insertion point of the masseter muscle immediately after surgery and at 24 h. The group control received only routine management . Parameters used for LLLT were : continuous mode , at 300 mW ( 0.3 W ) for a total of 180 s ( 60 s × 3 ) ( 0.3 W × 180 s = 54 J ) . Group test showed improvement in the interincisal opening and remarkable reduction of trismus , swelling and intensity of pain on the first and the seventh postoperative days . Although LLLT has been reported to prevent swelling and trismus following the removal of impacted third molars , some of these studies reported a positive laser effect while others did not . All references to the use of laser therapy in the postoperative management of third molar surgery employ different method ologies and , in some , explanations as to selection of their respective radiation parameters are not given . This study has demonstrated that LLLT , with these parameters , is useful for the reduction of postoperative discomfort after third-molar surgery Pain , swelling , and trismus are the most common complications after surgical removal of impacted lower third molars . The aim of this study was to evaluate the analgesic and anti-inflammatory effects of a low-level laser therapy ( Laser Smile ™ , Biolase ® , San Clemente , USA ) applied to the wound appeared after the surgical removal of impacted lower third molars . A prospect i ve , r and omized , and double-blind study was undertaken in 20 healthy patients with two symmetrically impacted lower third molars . The application of a low-level laser was made r and omly on one of the two sides after surgery . The experimental side received 5 J/cm2 of energy density , a wavelength of 810 nm , and an output power of 0.5 W. On the control side , a h and piece was applied intraorally , but the laser was not activated . Evaluations of postoperative pain , trismus , and swelling were made . The sample consisted of 11 women and nine men , and mean age was 23.35 years ( 18–37 ) .  The pain level in the first hours after surgery was lower in the experimental side than in the placebo side , although without statistically significant differences ( p = 0.258 ) . Swelling and trismus at the 2nd and 7th postoperative days were slightly higher in the control side , although not statistically significant differences were detected ( p > 0.05 ) . The application of a low-level laser with the parameters used in this study did not show beneficial affects in reducing pain , swelling , and trismus after removal of impacted lower third molars UNLABELLED Postoperative oedema is common following removal of impacted lower third molars . Several types of drug therapy ( corticosteroids , non-steroidal anti-inflammatory drugs , enzymes ) have been tried . The aim of this study was to compare the effectiveness of low-power laser ( LPL ) and dexamethasone after surgical removal of impacted lower third molars under local anaesthesia ( 2 % lidocaine/epinephrine ) . MATERIAL AND METHODS There were 120 healthy patients divided into four groups of 30 each . Group 1 received LPL irradiation 
    Output:
    
However , because of the heterogeneity of intervention and outcomes assessment and risk of bias of included trials , the efficacy is proved with limited evidence .