***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background . Pediatric hematopoietic cell transplant ( HCT ) is a lifesaving treatment that often results in physical and psychological discomfort . An acupressure-massage intervention may improve symptom management in this setting . Methods . This r and omized controlled pilot trial compared a combined massage-acupressure intervention to usual care .  Children were offered three practitioner-provided sessions per week throughout hospitalization . Parents were trained to provide additional acupressure as needed . Symptoms were assessed using nurses ' reports and two question naires , the behavioral affective and somatic experiences scale and the Peds quality of life cancer module . Results . We enrolled 23 children , ages 5 to 18 . Children receiving the intervention reported fewer days of mucositis ( Hedges ' g effect size ES = 0.63 ) , lower overall symptom burden ( ES = 0.26 ) , feeling less tired and run-down ( ES = 0.86 ) , having fewer moderate/severe symptoms of pain , nausea , and fatigue ( ES = 0.62 ) , and less pain ( ES = 0.42 ) . The intervention group showed trends toward increasing contentness/serenity ( ES = + 0.50 ) and decreasing depression ( ES = −0.45 ) , but not decreased anxiety ( ES = + 0.42 ) . Differences were not statistically significant . Discussion . Feasibility of study ing massage-acupressure was established in children undergoing HCT . Larger studies are needed to test the efficacy of such interventions in reducing HCT-associated symptoms in children OBJECTIVES massage can help relieve pain , although empirical evidence is scarce and contradictory . This study aims to assess the effectiveness of a massage protocol in relieving pain in children hospitalized with cancer . METHODS a r and omized , controlled , and single-blind trial was performed in a sample of 52 children aged between 10 and 18 years who were hospitalized in a pediatric cancer ward . The intervention consisted of the implementation of a massage protocol with three sessions of 20 to 30minutes on alternate days over a one-week period . The effectiveness of the protocol was evaluated by assessing pain using the Brief Pain Inventory ( BPI ) , while the effectiveness of each massage session was measured using the Visual Analogue Scale ( VAS ) . RESULTS the massage protocol was only effective in reducing the interference of pain in walking ( p<0.05 ) , although it also contributed to relieve pain and its impact on the children 's activities . After each massage session , the intensity of the pain experienced by the child decreased ( p<0.001 ) . CONCLUSIONS despite the small sample size , massage therapy appears to be a useful intervention in reducing pain in children with cancer . However , there are still questions regarding the effectiveness of this massage protocol . The authors recommend its use due to its contribution to the promotion of the child 's well-being and quality of life Objective Cancer treatment is reported to be stressful , and patients diagnosed with hematologic cancers often exhibit higher levels of anxiety and emotional distress than individuals with other malignancies . Management of these symptoms in patients with hematologic cancer presents significant challenges , as many of them are in and out of the hospital while undergoing high dose chemotherapy . Oncology patients use complementary modalities such as therapeutic massage in an attempt to alleviate disease and treatment-related symptoms , including anxiety and emotional distress . In the current study , the feasibility of a novel massage intervention delivered over the continuum of care , as well as assessment of the immediate and cumulative effects of massage , was examined in patients with acute myelogenous leukemia . Methods A mixed- methods , unmasked , prospect i ve , r and omized study was conducted with two groups : a usual care alone control group and a massage therapy intervention plus usual care group . Results Significant improvements in levels of stress and health-related quality of life were observed in the massage therapy group versus the usual care alone group , after adjusting for anxiety level , including both immediate and cumulative effects of massage . Conclusions While the findings of the current study regarding acceptability , feasibility , and potential efficacy of therapeutic massage as a complementary health-enhancing intervention in patients diagnosed with acute myelogenous leukemia are very promising , the relatively small size of the study sample limits generalizability Background : Previous research has shown positive effects from massage therapy ( MT ) for premature infants and for children with asthma , arthritis , and other illnesses . Although these effects have been demonstrated , MT research on children with cancer and blood disease is needed . Purpose and Setting : The present study , conducted at the Cancer Center , Sh and s Hospital , at the University of Florida , Gainesville , measured the physical and psychological effects of MT on pediatric oncology and hematology patients . The participants were 30 children with cancer or blood disease , ages 6 months to 17 years . Research Design : This r and omized , non-blinded prospect i ve study used measures of physical health and mental wellbeing that were completed before , during , and after four MT sessions were implemented . Descriptive statistics , one-way between-subjects analysis of variance , and an independent- sample s t-test were used to analyze the data . Intervention : The treatment group received 20-minute sessions of Swedish MT once daily for approximately 4 days ( in patients ) , or once weekly for approximately 4 weeks ( out patients ) ; the control group received no MT . Results : Between-groups analyses indicated significant psychological improvements for the MT group on state anxiety ( F1,58 = 16.79 , p < 0.000 ) , trait anxiety ( F1,58 = 3.95 , p < 0.000 ) , and emotional state ( F1,238 = 42.39 , p < 0.001 ) ] . Between-groups analyses indicated significant physical improvements for the MT group on muscle soreness ( F1,238 = 38.96 , p < 0.001 ) , discomfort ( F1,238 = 50.16 , p < 0.001 ) , respiratory rate ( F1,237 = 22.47 , p < 0.000 ) ] , and overall progress ( t28 = 25.55 , p < 0.000 ) . No significant differences were found between groups on parent-completed ratings of their child ’s physical or psychological health , pulse rate , or blood pressure . Conclusions : In children with cancer and blood diseases , MT can reduce psychological and physical distress and can have a positive effect on quality of life Background : Cardiovascular diseases have the highest death rates in human society . Coronary artery disease is among the most important of these diseases . No treatment of cardiovascular disease has as much impact on the quality of life of the patients as the heart surgery . The recovery from heart surgery is associated with symptoms of pain and psychological distress . In the early recovery period , the patients will face moderate symptoms of anxiety and depression . In this regard , various measures of nursing , as complementary therapy practice s have been performed to help the patients for overcoming the physical and psychological needs . One of these methods , in recent years has been the use of complementary and alternative therapies , particularly massage therapy , after heart surgery . Thus , the aim of this study was to determine the effectiveness of massage therapy on the mood of patients after open-heart surgery in Isfahan Chamran Hospital during 2010 - 11 . Material s and Methods : In this study 72 patients , who underwent coronary artery bypass surgery , were selected . They were r and omly assigned to the two case and control groups . The patients of the case group ( n = 36 ) received Swedish massage for 20 minutes in 4 sessions in 4 consecutive days , 3 to 6 days after the open-heart surgery . The patients in the control group received only the routine care . The mood question naire ( POMS ) which was used in this study has been completed the day before the start of the study and intervention and again after the last day of the intervention . SPSS software version 12 and descriptive and inferential statistical methods were used for data analysis . Findings : The comparison of study results showed that massage decreased the overall rating of the patients ’ mood after the surgery . Conclusions : The use of massage therapy as an effective nursing intervention can improve the patients ’ mood after open-heart surgery . Due to the low cost and simplicity of this method , it can perhaps be used as a complement to drug therapy and postoperative interventions used in these patients Background : Nausea and vomiting are the most common and unpleasant side effects of chemotherapy , and they may prevent successful treatment completion . Antiemetics not only can not control nausea and vomiting completely but also have numerous side effects . So it is necessary to find other methods for a better control . This study aim ed to assess the effect of massage therapy on chemotherapy-induced  nausea and vomiting in pediatric cancer . Material s and Methods : In this r and omized controlled clinical trial study , 70 patients ( 4 - 18 years of age ) under chemotherapy were divided into two ( massage therapy and control ) groups r and omly . In the massage group at 0.5 h and 24 h before and 24 h after chemotherapy , the patients were massaged ( Swedish massage ) for 20 min , respectively . All indices of nausea and vomiting ( incidence , severity , time , and length ) were assessed by Visual Analogue Scale ( VAS ) and BARF scales and other question naires and documented . Results : The results of Mann – Whitney and chi-squire tests indicated that in the massage group , the incidence of nausea was 25.7 % , the severity , length , and times of nausea were 20 % , 54 min , and 0.35 times , respectively , and the severity and times of vomiting were 0.24 scores and 0.31 times lower than those of the control group ( P < 0.05 ) , respectively . But vomiting incidence in the two groups showed no significant difference ( P = 0.192 ) . Conclusions : Massage therapy reduced chemotherapy-induced nausea and vomiting . So , nurses can use it and educate it to the patients ’ families . Nurses , besides using it clinical ly , can provide instructions to families for involving them in the treatment process and they feel they are more efficate in care of their suffering children BACKGROUND : Children undergoing stem cell transplantation ( SCT ) are thought to be at risk for increased distress , adjustment difficulties , and impaired health-related quality of life ( HRQL ) . We report results of a multisite trial design ed to improve psychological adjustment and HRQL in children undergoing SCT . METHODS : A total of 171 patients and parents from 4 sites were r and omized to receive a child-targeted intervention ; a child and parent intervention ; or st and ard care . The child intervention included massage and humor therapy ; the parent intervention included massage and relaxation/imagery . Outcomes included symptoms of depression and posttraumatic stress , HRQL , and benefit finding . Assessment s were conducted by patient and parent report at admission and SCT week+24 . RESULTS : Across the sample , significant improvements were seen on all outcomes from admission to week+24 . Surprisingly , patients who had SCT reported low levels of adjustment difficulties at admission , and improved to normative or better than average levels of adjustment and HRQL at week+24 . Benefit finding was high at admission and increased at week+24 ; however , there were no statistically significant differences between intervention arms for any of the measures . CONCLUSIONS : Although the results do not support the benefits of these complementary interventions in pediatric SCT , this may be explained by the remarkably positive overall adjustment seen in this sample . Improvements in supportive care , and a tendency for patients to find benefit in the SCT experience , serve to promote positive outcomes in children undergoing this procedure , who appear particularly resilient to the challenge Cancer and its treatment are stressful and reduce the quality of life in children . The aim of this study was to investigate the effect of massage therapy on pain and anxiety arising from intrathecal therapy or bone marrow aspiration in children with cancer . We conducted a controlled pretest/posttest quasi-experimental study at a paediatric oncology unit in Turkey . Twenty-five children were enrolled in this study . Their pain and anxiety were determined using a visual analogue scale . When the pretest and posttest pain and anxiety levels of the groups were compared , no statistically significant difference was found ( P > 0.05 ) . It was determined that pain and anxiety levels in the experimental group decreased significantly . This study provides preliminary evidence for the effectiveness in children of massage  in reducing pain and anxiety arising from intrathecal therapy or bone marrow aspiration 
    Output:
    
Conclusión : el masaje terapéutico mejora los síntomas de los niños con cáncer , que respalden los efectos que se le atribuyen .
Conclusão : a massagem terapêutica melhora os sintomas das crianças com câncer , mas são necessárias mais pesquisas que apoiem os efeitos atribuídos a ela