***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: OBJECTIVE The primary aim of this study was to investigate objective and subjective aspects of sexual adjustment for women with early stage cervical and endometrial cancer during the first 6 months post-treatment , compared to women with benign and pre-invasive gynaecological conditions . ' Objective ' aspects of sexual function were operationalised as the frequency of sexual activity and ' subjective ' aspects as the perceived quality of sexual interactions . METHOD This multi-centre controlled study compared sexual outcomes of women treated for early stage cervical and endometrial cancer ( n = 53 ) with ( i ) benign gynaecological patients ( n = 60 ) , as a comparison group for the physical effects of major pelvic surgery , and ( ii ) pre-invasive cancer patients ( n = 52 ) , as a comparison group for the emotional effect of the perceived threat of cancer . All patients were assessed at baseline and at 6 months follow-up using st and ardised measures of objective and subjective aspects of sexual function , overall satisfaction with sexual life , relationship satisfaction and psychological distress . RESULTS Despite experiencing treatment-related physical changes , women with early stage cervical and endometrial cancer did not report more severe or longer-lasting sexual sequelae than the benign or pre-invasive groups . There were no significant differences between the three groups or changes over time for the objective , subjective or overall measures of sexual function , controlling for age , psychological distress and relationship satisfaction . CONCLUSION The current findings suggest that early stage cervical and endometrial cancer patients fare as well as benign and pre-invasive cancer groups in terms of sexual adjustment over the 6 months post-treatment OBJECTIVE This study was undertaken to prospect ively evaluate the effect of early stage endometrial cancer , age , and obesity on quality of life ( QOL ) . STUDY DESIGN Women undergoing surgery for endometrial cancer or an adnexal mass determined at surgery to be benign ( controls ) were enrolled preoperatively and followed for 6 months . RESULTS Seventy-nine women completed the study .  Functional Assessment of Cancer Therapy ( FACT-G ) scores increased significantly in all women ; however , significant differences by patient weight and age were obtained . Obesity was associated with decreased physical FACT-G and SF-36 scores . Older women had lower SF-36 physical scores , higher emotional scores , and less change over time . CONCLUSION Women with early endometrial cancer had similar changes in QOL as those who received surgery for benign disease . Obese and elderly women had domain alterations . Given the aging population and rising incidence of obesity , these results emphasize the need for QOL interventions in postoperative gynecologic care of these patients Background To examine the effects of a 6 month lifestyle intervention on quality of life , depression , self-efficacy and eating behavior changes in overweight and obese endometrial cancer survivors . Methods Early stage endometrial cancer survivors were r and omized to intervention ( n = 23 ) or usual care ( n = 22 ) groups . Chi-square , Student 's t-test and repeated measures analysis of variance were used in intent-to-treat analyses . Outcomes were also examined according to weight loss . Results Morbidly obese patients had significantly lower self-efficacy , specifically when feeling physical discomfort . There was a significant improvement for self-efficacy related to social pressure ( p = .03 ) and restraint ( p = .02 ) in the LI group . There was a significant difference for emotional well-being quality of life ( p = .02 ) , self-efficacy related to negative emotions ( p < .01 ) , food availability ( p = .03 ) , and physical discomfort ( p = .01 ) in women who lost weight as compared to women who gained weight . Improvement in restraint was also reported in women who lost weight ( p < .01 ) . Conclusion This pilot lifestyle intervention had no effect on quality of life or depression but did improve self-efficacy and some eating behaviors . Trial Registration http://www . clinical trials.gov ; Purpose Exercise improves numerous psychosocial outcomes in cancer survivors ; however , few studies have examined posttraumatic growth . The primary objective of this study was to examine the association between exercise and posttraumatic growth in gynecologic cancer survivors ( GCS ) . Methods Using the Alberta Cancer Registry , a r and om sample of endometrial , ovarian , and cervical cancer survivors were mailed a self-report survey that assessed demographic and medical variables , aerobic and strength exercise , and posttraumatic growth using the posttraumatic growth inventory , impact of cancer scale , and benefit finding scale . Results Completed surveys were received from 621 ( 38 % ) of the 1,626 eligible survivors . One-third ( 32.9 % ) of GCS were meeting aerobic exercise guidelines and 19.0 % were meeting strength exercise guidelines . Multivariate analyses of covariance showed significant differences in the posttraumatic growth scales for aerobic exercise guidelines ( p < 0.001 ) and combined ( strength and aerobic ) exercise guidelines ( p < 0.001 ) . Analyses of covariance indicated significant differences favoring those meeting the aerobic exercise guidelines for the negative impact of cancer scale ( p < 0.001 ) and several of its subscales . Moreover , those meeting the combined exercise guidelines reported higher scores for the posttraumatic growth inventory ( p = 0.014 ) , the negative impact of cancer scale ( p < 0.001 ) , and several of their subscales compared to those meeting only one or neither guideline . Marital status moderated the association between exercise and posttraumatic growth with only unmarried GCS demonstrating the associations . Conclusion Exercise is a modifiable lifestyle factor that is associated with posttraumatic growth in GCS . R and omized controlled trials testing the effects of exercise interventions on posttraumatic growth in this population are warranted OBJECTIVE The majority of endometrial cancer survivors ( ECS ) are obese and at risk for premature death . The purpose of this study was to evaluate an intervention for ECS to promote weight loss and a healthy lifestyle . METHODS Early stage overweight and obese ( body mass index ≥ 25 ) ECS ( N=75 ) were r and omized to a  6-month lifestyle intervention ( LI ) or usual care ( UC ) . The LI group received education and counseling for six months ( 10 weekly followed by 6 bi-weekly sessions ) . Weight change at 12 months was the primary endpoint . Secondary outcomes included fruit/vegetable servings/day and physical activity ( PA ) . Multiple imputations were used for missing data and mixed models were used to analyze changes from baseline . RESULTS Adherence was 84 % and follow-up data were available from 92 % of participants at 6 months and 79 % at 12 months . Mean [ 95 % CI ] difference in weight change between LI and UC groups at 6 months was -4.4 kg [ -5.3 , -3.5 ] , p<0.001 and at 12 months was -4.6 kg [ -5.8 , -3.5 ] , p<0.001 . Mean [ 95 % CI ] difference in PA minutes between groups at 6 months was 100 [ 6 , 194 ] , p=0.038 and at 12 months was 89 [ 14 , 163 ] , p=0.020 . Mean difference in kilocalories consumed was -217.8 ( p<0.001 ) at 6 months and -187.2 ( p<0.001 ) at 12 months . Mean [ 95 % CI ] difference in fruit and vegetable servings was 0.91 servings/day at 6 months and 0.92 at 12 months ( p<0.001 ) . CONCLUSIONS Behavior change and weight loss are achievable in overweight and obese ECS , however , the clinical implication s of these changes are unknown and require a larger trial with longer follow-up OBJECTIVE More patient-centered programming is essential for endometrial cancer ( EC ) survivors needing to lose weight to reduce cardiovascular disease risk ( CVD ) . The purpose of this study was to improve self-efficacy ( SE ) and quality of life ( QOL ) using a lifestyle intervention program design ed for weight loss . METHODS Overweight and obese early-stage EC survivors , n = 75 , were r and omized into two groups : 1 )  Survivors of Uterine Cancer Empowered by Exercise and Healthy Diet ( SUCCEED )  , a six-month lifestyle intervention or 2 ) a usual care group ( UC ) . Participants completed the  Weight Efficacy Lifestyle Question naire ( WEL ) to assess SE and the Functional Assessment of Cancer Therapy-General ( FACT-G ) to measure QOL , and their body mass index ( BMI ) was calculated at baseline , 3 , 6 , and 12 months . Mixed , repeated- measures ANCOVA models with baseline covariates were employed using SPSS 20.0 . RESULTS Positive effects in every WEL domain , including the total score , were statistically significant in the SUCCEED group versus the UC group . A linear regression model demonstrated that , if BMI decreased by 1 unit , the total WEL score increased by 4.49 points . Significant negative correlations were found in the total WEL score and a change in BMI of R = -0.356 ( p = 0.006 ) . Between-group differences in the FACT-G were significant from baseline in the fatigue domain at three months ( p = .008 ) and in the physical domain at six months ( p = .048 ) . No other significant differences were found . CONCLUSION Overall , this study shows promise for targeted interventions to help improve SE , thus improving BMI Objective To determine the physical activity ( PA ) behavior , needs and preferences for underserved , ethnically diverse women with a history of endometrial cancer ( EC ) . Methods Women with a history of EC ( 41 non-Hispanic black , 40 non-Hispanic white , and 18 Hispanic ) completed a needs assessment during their regular follow-up appointments at Montefiore Medical Center in Bronx , NY , USA . An 8-week pilot PA intervention based on the results of the needs assessment was conducted with 5 EC survivors .  Results Mean body mass index ( BMI ) among the 99 respondents was 34.1±7.6 kg/m2 , and 66 % did not exercise regularly . Self-described weight status was significantly lower than actual BMI category ( p<0.001 ) . Of the 86 % who were interested in joining an exercise program , 95 % were willing to attend at least once weekly . The primary motivations were improving health , losing weight , and feeling better physically . Despite the high interest in participation , volunteer rate was very low ( 8 % ) . However , adherence to the 8-week  pilot PA intervention was high ( 83 % ) , and there were no adverse events . Body weight decreased in all pilot participants . Conclusion These data show that ethnically diverse EC survivors have a great need for , and are highly interested in , PA interventions . However , greater care needs to be taken to assess and identify barriers to increase participation in such programs PURPOSE To determine the long-term outcome and health-related quality of life ( HRQL ) of patients with endometrial carcinoma ( EC ) treated with or without pelvic radiotherapy in the Post Operative Radiation Therapy in Endometrial Carcinoma 1 ( PORTEC-1 ) trial . PATIENTS AND METHODS Between 1990 and 1997 , 714 patients with stage IC grade 1 to 2 or IB grade 2 to 3 EC were r and omly allocated to  pelvic external-beam radiotherapy ( EBRT ) or no additional treatment ( NAT ) .  HRQL was evaluated with the Short Form 36-Item ( SF-36 ) question naire ; subscales from the European Organisation for Research and Treatment of Cancer ( EORTC ) PR25 module for bowel and bladder symptoms and the OV28 and CX24 modules for sexual symptoms ; and demographic questions . Analysis was by intention-to-treat . RESULTS Median follow-up was 13.3 years . The 15-year actuarial locoregional recurrence rates were 5.8 % for EBRT versus 15.5 % for NAT ( P < .001 ) , and 15-year overall survival was 52 % versus 60 % ( P = .14 ) . Of the 351 patients confirmed to be alive with correct address , 246 ( 70 % ) returned the question naire . Patients treated with EBRT reported significant ( P < .01 ) and clinical ly relevant higher rates of urinary incontinence , diarrhea , and fecal leakage leading to more limitations in daily activities . Increased symptoms were reflected by the frequent use of incontinence material s after EBRT ( day and night use , 42.9 % v 15.2 % for NAT ; P < .001 ) . Patients treated with EBRT reported lower scores on the SF-36 scales " physical functioning " ( P = .004 ) and " role-physical " ( P = .003 ) . CONCLUSION EBRT for endometrial cancer is associated with long-term urinary and bowel symptoms and lower physical and role-physical functioning , even 15 years after treatment . Despite its efficacy in reducing locoregional recurrence , EBRT should be avoided in patients with low- and intermediate-risk EC Objective To prospect ively compare quality of life ( QOL ) outcomes in patients with advanced endometrial cancer treated with whole abdominal irradiation ( WAI ) or doxorubicin-cisplatin ( AP ) chemotherapy .  Methods Using the Fatigue Scale ( FS ) , Assessment of Peripheral Neuropathy ( APN ) , Functional Alterations due to Changes in Elimination ( FACE ) , and Functional Assessment of Cancer Therapy-General ( FACT 
    Output:
    
Results from the cross-sectional studies suggest that EC survivors ' inactivity is significantly correlated with poorer QoL. This correlation was worse among obese survivors compared with normal weight survivors .
Endometrial cancer survivors may benefit from interventions that incorporate PA .