***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Purpose The aim of this study was to compare the clinical efficacy of ultrasound-guided intra-articular injections of autologous platelet rich plasma ( PRP ) versus hyaluronic acid ( HA ) for symptomatic early osteoarthritis ( OA ) of the hip . Methods A prospect i ve controlled double-blinded r and omized trial on 80 patients with hip OA was conducted . The patients were divided in two groups of 40 patients each : group 1 underwent three PRP intra-articular ultrasound-guided injections , whereas group 2 underwent three HA injections .  WOMAC , VAS , and Harris Hip Score were evaluated for both groups before and at 6 and 12 months after treatment . Results The two groups were comparable in age , sex , body mass index , and severity of hip OA . Both groups showed a significant improvement from baseline at 6-month and 12-month follow-ups for all the outcome measures . No major complications were observed during the treatment and at follow-ups in both the groups . Conclusion PRP did not offer significantly better results compared with HA in patients with moderate signs of OA , and thus it should not be considered as first-line treatment . Level of Evidence Level II , r and omized controlled trial Introduction Comparison of intra-articular bacterial-derived hyaluronic acid ( Hyalubrix ® ) ( HA ) with local analgesia ( mepivacaine ) for osteoarthritis ( OA ) of the hip . Methods A pilot prospect i ve , double-blind , 6-month r and omized trial of 42 patients with hip OA .  HA or mepivacaine was administered twice ( once a month ) under ultrasound guidance . Efficacy measurements included the Lequesne 's algofunctional index , a visual analog scale for pain , concomitant use of analgesia , patient and physician global measurement , and safety . Results Patients in the HA group exhibited a significantly reduced Lequesne 's algofunctional index 3 and 6 months after treatment ( P < 0.001 ) and significantly reduced visual analog scale pain scores 3 and 6 months after treatment ( P < 0.05 ) compared with the local anesthetic group . All primary and secondary measures were significantly improved versus baseline , but other than the above were not different from each other at 3 or 6 months . Adverse effects were minimal . Conclusions This comparative study suggests a beneficial effect and safety of intra-articular HA in the management of hip OA.Trial registration numberIS RCT N39397064 Background To identify predictive factors of response to viscosupplementation ( VS ) in patients with hip osteoarthritis ( HOA ) . Methods Prospect i ve , multicentre , open-label trial , achieved in daily practice conditions . Patients with HOA were treated with a single intra-articular injection of a cross-linked hyaluronic acid combined with mannitol ( HAnox-M-XL ) , using imaging guidance .  WOMAC pain and function scores and patient global assessment ( PGA ) were assessed at baseline and day 90 . Improvement , satisfaction and efficacy were self-assessed at day 90.Hip radiographs at baseline were scored using Kellgren-Lawrence grade and Osteoarthritis Research Society International ( OARSI ) score . Associations between clinical and radiological features and response to VS ( pain improvement > 50 % at day 90 ) were assessed in univariate analysis , and then using logistic regression , adjusted for confounding factors . Results The intent-to-treat ( ITT ) population included 97 patients ( 57 females , mean age 63 ) . Ninety completed the follow-up and 80 had full clinical and radiological data . Response to VS  was achieved in 47.8 % of patients . In univariate analysis , the only clinical outcome statistically and negatively related to response was PGA at baseline ( p = 0.047 ) . Radiologically , response to VS was negatively correlated with joint space narrowing ( JSN ) score ( JSN < 2 vs. JSN ≥ 2 , p = 0.01 ) and was related to the patterns of femoral head migration ( p = 0.008 ) . In multivariate analysis , only JSN grade ( p = 0.03 ) remained significantly related to a poor response . Conclusion This pilot study , which needs further confirmation by larger scale trials , suggests that radiological features might be of importance for the decision of VS in patients with HOA.Trial registration numberID RCB N ° 2013-A00165 - 40 . Registered 31 January 2013 OBJECTIVE Several studies on knee osteoarthritis suggest that the intra-articular administration of hyaluronic acid products may be a relevant option in the management of patients with persistent pain . The aim of this study is to report the data of efficacy of US-guided HyalOne ® /Hyalubrix ® 60 injections in a large population of patients with hip osteoarthritis , repeated at least 2 times per year for up to seven years . PATIENTS AND METHODS This is a prospect i ve , post-marketing , cohort study . Data were collected from the ANTIAGE registry . Values of Lequesne index , pain VAS , NSAIDs intake , global medical and patients assessment s were evaluated every six months from the baseline to the end of the follow-up , seven years later . The inclusion criteria were : age ≥18 years , symptomatic hip osteoarthritis of at least 1-year duration , and up to 84 months of follow-up . All the patients received hyaluronic acid injections at least every six months , using ultrasound guidance to ensure accurate placement . RESULTS 1022 patients were included in the study . The patients were categorized by age classes , gender , and body mass index ( BMI ) . All the groups show a statistically significant reduction at all time points compared to baseline values of Lequesne index , pain VAS , NSAIDs intake , global medical and patients assessment s. There are slight differences in the subgroups of overweighted , obese and over 70 years patients . CONCLUSIONS Our study supports the clinical efficacy and safety of HyalOne ® /Hyalubrix ® 60 in patients affected by osteoarthritis . This is the first study , reporting on a large cohort of patients in different categories with a long follow-up on seven years . The data confirm the proper use of ultrasound-guided viscosupplementation ( VS ) as background therapy in the management of hip osteoarthritis Background : Intra-articular hyaluronic acid ( HA ) injection is used in management of knee , h and and hip osteoarthritis . While HA injection is included in the list of evaluated therapies , its efficacy and optimum dosing still have no consensus . This study was conducted to explore the possibility of using single injection HA to increase patient convenience while maintaining the therapeutic efficacy . Methods : We present a prospect i ve , open label , non-blinded , r and omized controlled trial performed in accordance with guidelines in principles of good clinical practice . Block r and omization was done for patients to receive either single 5 ml GO-ON injection or the conventional three injections of 2.5 ml GO-ON at weekly interval . Baseline Western Ontario McMaster University Osteoarthritis ( WOMAC ) scores were evaluated and recorded . All subjects were re-evaluated at 3 months and the WOMAC score recorded again as primary end points . Data analyses were performed with IBM SPSS Statistics for Windows software ( version 21.0 , IBM Corp , Armonk , New York , USA ) . Results : In the cohort of 127 patients , 33 were males and 94 females . The mean age was 59.1 years ( st and ard deviation ( SD ) = 7.25 ) in single injection arm and 60.1 years ( SD = 7.72 ) in triple injection arm . The two groups were recorded to have no significant difference in age ( p = 0.46 ) and Kellgren – Lawrence radiological grade ( p = 0.694 ) . There was significant increase in the WOMAC scores from the baseline ( pre-injection ) to that recorded 3 months after injection ( p < 0.001 ) in patients of both groups . However , there was no statistically significant difference noticed in this clinical improvement between the two arms ( p = 0.889 ) . Conclusion : The study shows single 5 ml dose regime comparing well with conventional three doses of 2.5 ml of intra-articular GO-ON HA injected at weekly intervals and confirms good efficacy , tolerability and safety of single larger dose of GO-ON knee intra-articular injection OBJECTIVE To obtain prospect i ve data on feasibility and safety of intra-articular injections of hylan G-F20 in patients with symptomatic hip osteoarthritis ( OA ) . METHODS Fifty-seven patients with primary hip OA , Kellgren-Lawrence grade II-III , aged > or = 40 and walking pain 50 - 90 mm on a visual analogue scale ( VAS ) were enrolled in an open-label , multicentre pilot trial . Hylan G-F20 ( 2 ml ) was injected intra-articularly ( IA ) in the hip under fluoroscopy at D0 , and follow-up visits were performed at D7 - 30 - 60 - 90 . The possibility of a second injection at D30 - 60 or 90 was considered if the reported pain level was equivalent to baseline . Adverse events , walking pain ( VAS ) , WOMAC index , patient and physician 's global assessment were recorded at each visit . RESULTS Twenty-five patients 1 injection and 32 received 2 injections . Transient hip pain was reported following 10.1 % of injections , but no patient withdrew from the study because of this . Two mild synovial fluid aseptic effusions occurred after the first injection . No systemic device-related adverse event was reported . Walking pain decreased from 69.3 mm at entry to 39.5 mm at the end point ( p < 0.0001 ) . All other outcome measures decreased significantly . CONCLUSION Viscosupplementation with hylan G-F20 is feasible , easy to perform and well-tolerated in hip OA . A double-blind , controlled study should be performed to confirm data on its efficacy This paper aims to compare the results of single-joint knee vs hip hyaluronic acid ( HA ) injections in patients with osteoarthritis ( OA ) involving both the knee and hip joints . Thirty-eight patients who were diagnosed to have both hip and knee OA were enrolled . Patients were divided into two groups to receive HA injection three times at 1-week intervals either to the hip or knee joints . Pain level during activities and rest was measured by using visual analog scale ( VAS ) . Western Ontario and McMaster University Osteoarthritis Index ( WOMAC 5-point Likert 3.0 ) was also used prior to the injections and 1 month after the 3rd injection . In the knee injection group , the intragroup analysis revealed significant improvements in VAS activity pain , VAS rest pain , and WOMAC pain values following injection when compared with preinjection values , while no significant difference was detected in WOMAC stiffness , WOMAC physical function , and WOMAC total values . In the hip injection group , VAS activity pain , VAS rest pain , WOMAC pain , WOMAC stiffness , WOMAC physical function , and WOMAC total values showed significant improvement after the injection when compared with preinjection values . Although statistically not significant ( p > 0.05 ) , the comparison of the differences ( preinjection – postinjection ) between the groups demonstrated higher values in the hip injection group . We imply that intra-articular single-joint HA injections either to the knee or hip joints in OA patients with involvement of both of these joints are effective with regard to pain and functional status AIM To compare the efficacy of ultrasound-guided intra-articular ( IA ) treatment with platelet-rich plasma ( PRP ) versus viscosupplementation ( hyaluronic acid HA ) in hip osteoarthritis . METHODS : A total of 43 patients affected by monolateral severe hip osteoarthritis ( OA ) were included in the study . Patients were r and omized to receive either intra-articular PRP ( 3 ml ) or HA ( 30 mg/2 ml ; 1,000 - 2,900 kDa ) , 3 injections in total - 1/week . Clinical assessment s for each patient were made at baseline ( T0 ) , 4 ( T1 ) , and 16 weeks ( T2 ) of follow-up . The primary efficacy outcome was pain reduction as measured by VAS and by WOMAC pain subscale . RESULTS Data analysis revealed that , compared to T0 , in the PRP-treated group VAS scores significantly decreased at T1 but not at T2 , thereby indicating an early effect on pain which was not maintained at a longer term follow-up . In the HA group a significant decrease of both VAS and WOMAC values was registered only between T0 and T2 . CONCLUSIONS Intra-articular PRP had an immediate effect on pain that was not maintained at longer term follow-up when , on the contrary , the effects of intra-articular HA were evident INTRODUCTION Young adult hip osteoarthritis ( OA ) is a noteworthy problem , although rarer than the elderly form of the disease , causing limitations in social and working activities and prospect s. Treatment options are scarce and surgical procedures , frequently necessary , imply the major drawback of revising the prostheses periodically , whereas chronic nonsteroidal anti-inflammatory drugs ( NSAID ) consumption may provoke side effects . To explore alternative options to both surgery and long-term NSAID use , especially in the case of young patients , viscosupplementation seems to appear as an appropriate tool to relieve pain , ameliorate the function and delay surgery . AIM OF THE STUDY In this study we tackle the issue of the use of hyaluronic acid ( HA ) injections in young adults with symptom 
    Output:
    
There was inconsistent evidence across studies regarding the effectiveness of HA compared to other intra-articular injections .
The formulation of the administered viscosupplementation did not appear to influence outcomes .
Furthermore , rates of conversion to THA were relatively low when evaluating 1- to 4-year follow-up intervals .
Discussion Non-comparative studies consistently demonstrated that HA can achieve satisfactory pain reduction and functional improvement .
However , there was not enough evidence in the current literature regarding whether HA is superior to placebo or other types of intra-articular injections .