***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: BACKGROUND To evaluate the effect of individualized education for patients with type 2 diabetes mellitus ( T2DM ) . METHODS A total of 280 patients ( 158 males , mean age 63 ± 10 years ) with T2DM were r and omly divided into study and control group .  Eysenck Personality question naire  was used to assess the personality of the patients in the study group , which was provided us one-on-one counseling and individualized management plan . Group education was provided to the control group . RESULTS At the end of the study , the body mass index ( 21.5±2.5 vs 23.6±1.6 kg/m2 , P = 0.002 ) , waist circumference ( 83.7±6.4 vs 85.7±7.7 cm , P = 0.03 ) , fasting blood glucose ( 6.0±0.8 vs 6.9±2.1 mmol/L , P = 0.004 ) , HbA1c ( 6.2±0.6 % vs 6.9±3.1 % , P = 0.03 ) , systolic blood pressure ( 130.1±8.8 vs 135.1±8.4 mmHg , P = 0.003),triglyceride ( 1.21±0.66 vs 1.46±0.58 mmol/L ) and low-density lipoprotein ( 2.36±0.44 vs 2.84±0.64 mmol/L , P = 0.03 ) in the study group was lower than in the control group . CONCLUSION Individualized diabetes education  is more effective than group education in facilitating the control of type 2 diabetes OBJECTIVE To investigate the effect of continuous intravenous injection of nicardipine and /or nitroglycerin with or without esmolol on the occurrence of early post-operative cognitive dysfunction ( POCD ) in elderly patients . METHODS Elderly patients ( n=340 ) who underwent radiofrequency ablation for atrial fibrillation were r and omized into five groups : A , nicardipine ; B nicardipine+esmolol ; C , ( nitroglycerin ) group ; D nitroglycerin+esmolol ; E ( control ) groups . The hemodynamic parameters were recorded , and Mini Mental State Examination was used to assess cognitive function . RESULTS At 30 min and 60 minutes after anesthesia and at the conclusion of surgery , the rate pressure product value was significantly lower in Groups B ( 10621.1±321.7 , 10544.2±321.8 , and 10701.3±325.5 , respectively ) and D ( 10807.4±351.1 , 10784.3±360.3 , and 10771.7±345.7 , respectively ) than in Group E ( 13217.1±377.6 , 13203.5±357.3 , and 13119.2±379.5 , respectively ) . The heart rate was significantly higher in Groups A ( 104.1±10.3 , 104.9±11.1 , and 103.9±11.8 , respectively ) and C ( 103.7±11.3 , 105.5±10.5 , and 107.7±11.7 , respectively ) than in Group E ( 89.3±12.0 , 88.5±11.5 , and 85.5±11.6 , respectively ) . The incidence of POCD was significantly lower in Groups A and B than in Groups C , D , and E. Univariate regression analysis showed that regimens in Groups A , B , and E and doses of propofol and fentanyl were risk factors for POCD . Multivariate logistic regression analysis revealed significant associations between the incidence of POCD and interventions in Groups A and B. CONCLUSION Maintenance of stable intraoperative hemodynamics using nicardipine and nitroglycerin or their combinations with esmolol , especially nicardipine with esmolol , reduced the incidence of POCD in the elderly with potential cardiovascular diseases OBJECTIVES The objectives of the study were to determine the prevalence and socio-economic determinants of autism among children attending primary and secondary schools in South East , Nigeria . METHODS This was a cross-sectional study that assessed the prevalence and socio-economic pattern of childhood autism among children attending primary and secondary schools in Enugu and Ebonyi states , South East Nigeria . The question naire was adapted from American Psychiatric Association : Diagnostic and Statistical Manual of Mental Disorders ( DSM-IV-TR , 2000 ) . The study was carried out between June and October , 2014 . The schools were selected by listing all the mixed schools in the urban and semi- urban areas by simple r and om sampling . RESULTS A total of 721 subjects completed the question naire . The age of respondents ranged between 3 and 18 years , with mean age of 12.71 and st and ard deviation of 3.03 years . Twenty one children fulfilled the criteria for autism giving a prevalence of 2.9 % . There is a significant association between age in categories ( fishers exact test , p = 0.013 ) and social class ( p=0.033 ) . CONCLUSION The prevalence of autism was 2.9 % ; and the socio-economic characteristics of childhood autism in South East Nigeria are similar to those in other parts of the world BACKGROUND Illicit use of high dosage buprenorphine has been well documented in several countries , including Tunisia . OBJECTIVES The aim of this survey is to assess the buprenorphine withdrawal syndrome time course , and how it may be affected by the population characteristics among subjects admitted to a rehabilitation center in Tunisia . METHODS A prospect i ve research has permitted study of the socio-demographic characteristics and assessment of buprenorphine withdrawal syndrome among 32 subjects admitted for buprenorphine dependence by using the clinical opiate withdrawal scale . An ANOVA was conducted to examine the effect of different factors on the withdrawal scores . RESULTS 32 subjects were included . Among them 30 were males , 27 had been injecting buprenorphine , 16 were poly-drug abusers and 2 had a history of mental disorders . Buprenorphine withdrawal syndrome was of a mild intensity and had a delayed onset . Withdrawal mean scores varied between 0 and 9 , and maximum values were reached at day 21 . These scores varied significantly over time ( p<0,001 ) . The sex v time interaction and the mode of consumption of buprenorphine had significant effects on the withdrawal scores ( p<0,001 ) . The poly-drug consumption and the history of mental disorders did not have any significant effect on the withdrawal scores . CONCLUSION This study has permitted description of buprenorphine withdrawal syndrome among patients going through a detoxification treatment at a rehabilitation center . Underst and ing this syndrome would help elaborate effective and suitable buprenorphine dependence management plans 
    Output:
    
They assert that ‘ ‘ locally made mobile community videos are effective in improving knowledge , attitudes , practice s and use of maternal and child health messages among rural semi-illiterate