***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: In aesthetic sites , the integrity of the facial bone wall dimension in the anterior maxilla is jeopardized by physiologic and structural changes post extraction . An effective regenerative protocol is key to reestablish and maintain the hard and soft tissue dimensions over time . The present prospect i ve case series study examined the effectiveness of early implant placement with simultaneous contour augmentation through guided bone regeneration with a 2-layer composite graft in post extraction single-tooth sites over an observation period of 10 y among 20 patients . The median peri-implant bone loss was 0.35 mm between the 1- and 10-y examination . A success rate of 95 % was obtained , with pleasing aesthetic outcomes and a high median Pink Esthetic Score ( 8) . Implant crowns ( ICs ) revealed significant median facial recession between IC10y and IC1y ( 0.17 mm ) . The facial bone wall dimensions were assessed by preoperative cone beam computed tomography and 2 subsequent scans taken at 6 and 10 y. The median facial bone wall thickness increased significantly from 0 mm at surgery to 1.67 mm at the 10-y examination . The facial vertical bone wall peak ( DIC ) was located at a median distance of 0.16 mm coronal to the implant shoulder . The facial vertical bone loss of DIC amounted to 0.02 mm between 6 and 10 y. Equivalence testing was performed for the null hypothesis of a difference of > 0.2 mm per year between 2 respective time points , showing stable bone conditions . Modulating factors influencing the regenerative outcomes at 10 y were the preoperative proximal crest width and soft tissue thickness . In conclusion , the present study confirmed the long-term effectiveness of early implant placement with simultaneous contour augmentation through guided bone regeneration with a 2-layer composite graft in post extraction single-tooth sites offering stable bone conditions with low risks of mucosal recessions over an observation period of 10 y ( Clinical Trials.gov NCT03252106 ) OBJECTIVE Our purpose was to measure the agreement , reliability , construct validity , and feasibility of a measurement tool to assess  systematic review s ( AMSTAR ) . STUDY DESIGN AND SETTING We r and omly selected 30 systematic review s from a data base . Each was assessed by two review ers using : ( 1 ) the enhanced quality assessment question naire ( Overview of Quality Assessment Question naire [ OQAQ ] ) ; ( 2 ) Sacks ' instrument ; and ( 3 ) our newly developed measurement tool ( AMSTAR ) . We report on reliability ( interobserver kappas of the 11 AMSTAR items ) , intraclass correlation coefficients ( ICCs ) of the sum scores , construct validity ( ICCs of the sum scores of AMSTAR compared with those of other instruments ) , and completion times . RESULTS The interrater agreement of the individual items of AMSTAR was substantial with a mean kappa of 0.70 ( 95 % confidence interval [ CI ] : 0.57 , 0.83 ) ( range : 0.38 - 1.0 ) . Kappas recorded for the other instruments were 0.63 ( 95 % CI : 0.38 , 0.78 ) for enhanced OQAQ and 0.40 ( 95 % CI : 0.29 , 0.50 ) for the Sacks ' instrument . The ICC of the total score for AMSTAR was 0.84 ( 95 % CI : 0.65 , 0.92 ) compared with 0.91 ( 95 % CI : 0.82 , 0.96 ) for OQAQ and 0.86 ( 95 % CI : 0.71 , 0.94 ) for the Sacks ' instrument . AMSTAR proved easy to apply , each review taking about 15 minutes to complete . CONCLUSIONS AMSTAR has good agreement , reliability , construct validity , and feasibility . These findings need confirmation by a broader range of assessors and a more diverse range of review The purpose s of this preliminary study are to assess the risk of developing bisphosphonate-related osteonecrosis of the jaw ( BRONJ ) in a patient with osteoporosis using zoledronic acid  and to report the results of a 1-year prospect i ve clinical study regarding 5 immediately inserted implants in the anterior m and ible . For this comparative prospect i ve study , 24 female patients , aged ≥54 years , were chosen , all with partially edentulous m and ibles . Group A consisted of 12 patients with osteoporosis taking zoledronic acid receiving a once-yearly intravenous infusion of zoledronic acid ( 5 mg ) . Control group B consisted of 12 other patients without osteoporosis and not taking drugs .  In both groups , the remaining teeth were extracted before 120 implants , 3.7-mm wide and 16-mm long , were immediately installed in the interforaminal region of the m and ibles . The 1-year implant survival rate was 100 % . No apparent necrotic bone was observed among patients receiving zoledronic acid ( group A ) after implant surgery . Immediate implant osseointegration can be successful in a patient with osteoporosis using bisphosphonates  , suggesting the safety of implantology as a treatment modality BACKGROUND Phosphate-induced hyperparathyroidism still represents an intriguing problem in dialysis patients . Postpr and ial hyperphosphataemia is considered to be the main stimulus to parathyroid hyperfunction , and therefore many efforts have focused on the use of phosphate binders to prevent phosphate absorption . METHODS We investigated whether the pH-mediated gastric ionization of calcium phosphate dietary salts is necessary for its intestinal absorption . In eight normal subjects we measured 24-h urinary calcium phosphate excretion and the postpr and ial blood calcium phosphate profile after a meal containing 1 g of calcium and 2 g of phosphate salts in a crossover placebo-omeprazole study . On two occasions the subjects received either placebo or omeprazole 60 mg/day 2 days before and during the day test . RESULTS Serum gastrin levels were measured as an indicator of achlorhydria and were 13.7 + /- 1 pg/ml after placebo and 30.4 + /- 4.7 after omeprazole ( P < 0.003 ) . Postpr and ial plasma phosphate profiles were not significantly different between the two studies ( + 36 + /- 8 % after placebo and + 24 + /- 8 % after omeprazole , NS ) , while plasma calcium increased by + 6.1 + /- 1 % after placebo and decreased by -4.2 + /- 0.7 % after omeprazole ( P < 0.01 ) . The 24-h urinary phosphate excretion was 1068 + /- 85 mg after placebo and 773 + /- 55 after omeprazole ( P < 0.002 ) , while the 24-h urinary calcium excretion was 360 + /- 21 after placebo and 238 + /- 15 after omeprazole ( P < 0.0001 ) . A negative relationship was observed between absolute changes in plasma gastrin and those in urinary calcium ( P < 0.009 ) and phosphate ( P < 0.05 ) . CONCLUSIONS The inhibition of gastric acid secretion by omeprazole significantly reduces both urinary phosphate and calcium excretion after an oral load . The behaviour of the postpr and ial calcium-phosphate plasma profile suggests that gastric acid inhibition is more effective in reducing calcium rather than phosphate dietary salts absorption in normal subjects PURPOSE This r and omised double-blind placebo-controlled trial was carried out to investigate the effect of a one-week post-operative course of 600 mg of ibuprofen taken four times a day on marginal bone level around dental implants . MATERIAL S AND METHODS A total of 61 patients were allocated to the ibuprofen ( 31 patients ) or placebo group ( 30 patients ) . Overall , 132 implants were inserted , 67 implants in the ibuprofen group and 65 implants in the placebo group . Preparation of the implant sites was carried out with an intermittent drilling sequence adapted to the fixture diameter and the local bone quality according to the Astra Tech implant installation guide . The primary outcome measure was the change in marginal bone level around dental implants from the baseline ( 2 weeks post-placement ) to the 3- and 6-month radiographic examinations . The paralleling technique and a film holder coupled to a beam aim ing device were used to take the periapical radiographs . Measurement of changes in bone level was made using a viewing box and x8 magnifier . RESULTS Two patients from the ibuprofen group were unable to complete the prescribed course of ibuprofen owing to a minor self-reported stomach upset . A patient from the control group did not attend any of the scheduled appointments following implant placement . A total of three patients dropped out . All implants survived in either group during the 6-month observation period . The mean marginal bone level changes from the baseline were ( -0.33 mm ) at the 3-month and ( -0.29 mm ) at the 6-month follow-up for the ibuprofen group while the corresponding values for the placebo group were ( -0.12 mm ) and ( -0.30 mm ) . There were no statistically significant differences between groups for mean marginal bone level changes at 3 months ( P = 0.27 ) or 6 months ( P = 0.97 ) . CONCLUSIONS Administration of a short course of systemic ibuprofen for post-operative pain management subsequent to implant placement may not have a significant effect on the marginal bone around dental implants in the early healing period 
    Output:
    
The present systematic review showed an association of PPIs and SSRIs with an increased implant failure rate .