***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: PHY906 is a Chinese medicine formula with cl aims for the treatment of severe gastrointestinal distress . PHY906 enhanced the therapeutic index of various chemotherapeutic agents in human hepatocellular carcinoma xenografts . Accordingly , here a phase I/II clinical study was conducted with the combination of capecitabine in patients with advanced , unresectable hepatocellular carcinoma . More than 60 % of patients had either stable disease or better after two treatment cycles . Median overall survival was 9.2 months . Asian patients had a higher median overall survival ( 16.5 months ) than non-Asian patients ( 6.2 months , p=0.03 ) . Patients ' quality of life did not deteriorate significantly during treatment . This finding supported further investigation of PHY906 as an adjuvant therapy of capecitabine in a larger hepatocellular cancer population OBJECTIVE To observe the clinical effect of cinobufacini injection in treating moderate and advanced primary liver cancer ( PLC ) . METHODS One hundred patients with moderate and advanced PLC were r and omly divided into cino-treated group ( 50 patients ) and control group ( 50 patients ) . The quality of life , tumor size , some changes of laboratory tests , and survival time were observed . RESULTS The progressive rate of cino-treated group ( 18 % ) was lower than that of the control group ( 32 % ) . The quality of life of the cino-treated group ( 80 % ) was better than that of the control group ( 72 % ) , but without statistical significance . The survival rate of > 12 months of the cino-treated group ( 30 % ) was higher than that of the control group ( 18 % ) . The patients ' liver function such as serum total bilirubin and ALT decreased obviously in the cino-treated group while increased a lot in the control group . The level of AFP increased after treatment with statistical significance in the control group while there was no statistical significance in the cino-treated group . CONCLUSION Cinobufacini injection can not only inhibit the proliferation of cancer , but also protect liver function , improve quality of life and prolong survival time AIM To investigate anti-tumor activities and apoptosis-regulated mechanisms of bufalin in the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice . METHODS BEL-7402 cells of human hepatocellular carcinoma were inoculated to form subcutaneous tumors , and were implanted into the liver to establish orthotopic transplantation tumor models of human hepatocellular carcinoma in nude mice . Seventy-five animals were r and omized divided into five groups ( n = 15 ) . Bufalin was injected intraperitoneally into three groups at doses of 1.5 mg/kg ( BF1 ) , 1 mg/kg ( BF2 ) and 0.5 mg/kg ( BF3 ) for d 15 - 24 , respectively . The NS group was injected an equal volume of saline as above and adriamycin was injected intraperitoneally into the ADM group at a dose of 8.0 mg/kg for d 15 . Ten mice in each group were killed at d 25 and the survival time in each group was calculated . We also observed the morphologic alterations in the myocardium , brain , liver , kidney and tumor tissues by pathology and electron microscopy , measured the apoptotic rate by TUNEL staining method , and detected the expression of apoptosis-regulated genes bcl-2 and bax by immunohistochemical staining and RT-PCR in tumor tissues . RESULTS The tumor volumes in each group of bufalin were reduced significantly ( 35.21 + /- 12.51 vs 170.39 + /- 25.29 ; 49.83 + /- 11.46 vs 170.39 + /- 25.29 ; 83.99 + /- 24.63 vs 170.39 + /- 25.29 , P < 0.01 , respectively ) , and the survival times were prolonged in group BF1 - 2 ( 31.8 + /- 4.2 vs 23.4 + /- 2.1 and 29.4 + /- 3.4 vs 23.4 + /- 2.1 , P < 0.05 , respectively ) , and necrosis was mainly in severe or moderate degree in group BF1 - 2 . No morphological changes were detected in the myocardium , brain , liver and kidney tissues . Apoptotic characteristics could be seen in group BF1 - 2 . The positive rates of bcl-2 and bax protein expression of each group by immunohistochemical staining were 10.0 % , 10.0 % , 20.0 % , 10.0 % and 20.0 % ; 90.0 % , 80.0 % , 80.0 % , 40.0 % and 30.0 % , respectively . Loss of expression of bcl-2 mRNA in each group was to be found and the density of bax mRNA was increased progressively with increase of dose of bufalin by RT-PCR . CONCLUSION Bufalin has significant anti-tumor activities in the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice with no marked toxicity and was able to induce apoptosis of transplanted tumor cells . This apoptosis may be mediated mainly via up-regulating the expression of apoptosis-regulated gene bax , which may be involved in its anti-tumor mechanism of bufalin Purpose To study a commonly used Astragalus-based herbal formula previously found effective in non-small cell lung cancer ( NSCLC ) on the pharmacokinetics of docetaxel in patients with NSCLC . Methods Patients with advanced NSCLC who progressed after prior platinum-containing chemotherapy were accrued and received docetaxel at 35 mg/m2 for 3 weeks followed by 1 week of rest . At 4 days prior to the second dosing , Jinfukang was given orally . Pharmacokinetic studies of initial-dose docetaxel ( in the absence of Jinfukang ) and the third dose ( in the presence of Jinfukang ) were compared . Results Of the 24 patients enrolled , 21 started Jinfukang and docetaxel . Jinfukang had no significant impact on the pharmacokinetics of docetaxel .  Median time to progression or withdrawal from treatment was 7 weeks . Twelve patients were removed from study for progression of disease ; nine patients withdrew . Conclusions Jinfukang did not alter the pharmacokinetics of docetaxel nor appear to affect survival in this study Huachansu , a Chinese medicine that comes from dried toad venom from the skin gl and s of Bufo gargarizans or B. melanostictus , has been used in the treatment of various cancers in China . The authors conducted a pilot study , using a phase 1 trial design , of huachansu in patients with advanced cancer 
    Output:
    
The underst and ing of TCM Syndrome Differentiation may allow identification of different patterns of disharmony and may provide important guidance to the prescription of CHM .