***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background : Stomatitis is a common oral complication which affects 100 % of patients undergoing head and neck radiotherapy . Acute stomatitis might cause failure and delay radiotherapy . Attention to mouth hygiene , particularly using mouthwash , has a fundamental importance for these patients . Objectives : The current study came to addresses the effects of pure natural honey on radiation-induced stomatitis in patients with a variety of head and neck cancers . Patients and Methods : The present single-blinded nonr and omized controlled trial was conducted on 105 patients undergoing radiotherapy due to head and neck cancer at the radiation unit of Shafa hospital in Kerman , Iran , from October 2012 to March 2012 . The research groups were selected by writing the names of the protocol s ( the mouthwashes of chamomile , honey and the common caring protocol at ward which uses water ) on three cubes . The first extracted cube was related to the chamomile mouthwash ( Matrica ) , the second to the honey mouthwash and the last cube to the water mouthwash . The first experimental group ( n = 35 ) gurgled a solution containing 20 mL diluted honey , the second group gurgled a solution containing German chamomile , and the 35 patients in the control group were advised to gurgle 20 mL water ( the ward routine ) . Results : The results showed that severe stomatitis in groups of honey , chamomile and control was 0 , 5.7 % , and 17.6 % , respectively . On the 14th day , it was 0 , 0 , and 17.6 % , respectively . There were significant differences between the three groups regarding the severity of stomatitis in the 14th day ( P < 0.001 ) . Conclusions : The application of natural honey is effective in managing and preventing radiation-induced stomatitis in patients with head and neck cancers In spite of being one of the most investigated subjects among supportive care in cancer , no therapy has been found effective in treatment of chemotherapy-induced oral mucositis . Based on the observations that honey bees products have anti-inflammatory and wound healing effects , the present study tried to evaluate the effect of topical application of honey and a mixture of honey , olive oil – propolis extract , and beeswax ( HOPE ) in treatment of oral mucositis . This was a r and omized controlled clinical trial conducted on 90 patients with acute lymphoblastic leukemia and oral mucositis grade s 2 and 3 . The mean age of enrolled patients was 6.9 years . The patients were assigned into 3 equal treatment groups : Honey , HOPE , and control groups . Topical treatment for each patient consists of honey , HOPE , and benzocaine gel for honey , HOPE , and control groups , respectively . Recovery time in grade 2 mucositis was significantly reduced in the honey group as compared with either HOPE or controls ( P < .05 ) . In grade 3 mucositis , recovery time did not differ significantly between honey and HOPE ( P = 0.61 ) but compared with controls , healing was faster with either honey or HOPE ( P < .01 ) . Generally , in both grade s of mucositis , honey produced faster healing than either HOPE or controls ( P < .05 ) . Based on our results that showed that honey produced faster healing in patients with grade 2/3 chemotherapy-induced mucositis , we recommend using honey and possibly other bee products and olive oil in future therapeutic trials targeting chemotherapy-induced Background The aim of this study was to evaluate the effect of pure natural honey on  radiation-induced mucositis .  Patients and methods Forty patients diagnosed with head and neck cancer requiring radiation to the oropharyngeal mucosal area were divided in to two groups to receive either radiation alone or radiation plus topical application of pure natural honey . Patients were treated using a 6-MV linear accelerator at a dose rate of 2 Gy per day five times a week up to a dose of 60–70 Gy . In the study arm , patients were advised to take 20 ml of pure honey 15 min before , 15 min after and 6 h post-radiation therapy . Patients were evaluated every week for the development of radiation mucositis using the Radiation Therapy Oncology Group ( RTOG ) grading system . Main results There was significant reduction in the symptomatic grade 3/4 mucositis among honey-treated patients compared to controls ; i.e. 20 % versus 75 % ( p 0.00058 ) . The compliance of honey-treated group of patients was better than controls . Fifty-five percent of patients treated with topical honey showed no change or a positive gain in body weight compared to 25 % in the control arm ( p 0.053 ) , the majority of whom lost weight . Conclusions Topical application of natural honey is a simple and cost-effective treatment in radiation mucositis , which warrants further multi-centre r and omised trials to vali date our finding Purpose The aim of this study is to compare cryotherapy made only with water and cryotherapy made with chamomile infusion for prevention and reduction of intensity of oral mucositis in patients with cancer receiving 5-fluorouracil and leucovorin . Method This is a r and omized pilot study with two groups : cryotherapy made only with water ( control group , n = 18 ) and cryotherapy made with chamomile infusion ( chamomile group , n = 20 ) . Both groups were instructed to swish the ice around in their oral cavity for at least 30 min during chemotherapy . Assessment of oral mucosa occurred on days 8 , 15 , and 22 after the first day of chemotherapy . Results Fifty percent of the patients in the control and 30 % in the chamomile group developed oral mucositis . Mouth pain score was higher in patients in the control group on all evaluations ( p = 0.02 for day 8 , p = 0.09 for day 15 , and p = 0.14 for day 22 ) . Patients in the chamomile group never developed mucositis with grade 2 or higher . Presence of ulceration was statistically significant on day 8 ( 16 % in the control vs. 0 % in the chamomile group , p = 0.10 ) , but not in days 15 and 22 , although 11 % still had ulcerations in the control group and none in the chamomile group . Conclusion The occurrence of oral mucositis was lower in patients in the chamomile group than in the control group . When compared to the controls , the chamomile group presented less mouth pain and had no ulcerations .  Cryotherapy was well tolerated by both groups , and no toxicity related to chamomile was identified Oral mucositis is a common , debilitating complication of cancer patients undergoing chemotherapy and radiotherapy , occurring in about 40 percent cases . Mucositis may limit the patient 's ability to tolerate chemotherapy or radiation therapy , and nutrition status is compromised . The aim of the study was to assess the effect of Indian turmeric powder with honey as a complementary therapy on treatment induced oral mucositis . In the study , quasi experimental non-equivalent control group pre test post-test design was used and non-probability purposive sampling technique was adopted to select 60 cancer patients with treatment induced oral mucositis , 30 each in experimental and control group . The independent ' t ' value for post-test 2 and 3 ( post-test 2 : 2.86 for WHO OMAS and 4.58 for MPJ OMAS , post test 2 : 5.42 for WHO OMAS and 7.2 for MPJ OMAS ; p < 0.05 ) were significant between experimental and control group . It is inferred that the application of Indian turmeric and honey on treatment-induced oral mucositis is effective Background : Oral mucositis is a common inflammatory complication among patients undergoing hematopoietic stem cell transplantation ( HSCT ) . Among its therapeutic properties , Chamomilla recutita has anti-inflammatory effects . Objective : The aim of this study was to identify the dosage of the liquid extract of C recutita in mouthwash that is needed to reduce the incidence and intensity of oral mucositis in adult patients undergoing allogenic HSCT . Methods : In a r and omized phase II clinical trial , 40 patients were r and omized to receive routine care plus mouthwash containing a liquid extract of C recutita at 0.5 % , 1 % , or 2 % ( experimental groups ) or st and ard care alone ( control group ) . Daily evaluation was performed using the measurement scale for oral toxicity defined by the World Health Organization . Statistical analysis was performed , in which the incidence , intensity , and duration of oral mucositis were compared between each experimental group and the control group . Results : The experimental group at the 1 % dosage demonstrated reduced incidence , intensity , and duration of oral mucositis compared with the control group . The formulation was well tolerated by patients and was safe , as no moderate or severe adverse effects were identified . Conclusions : In this study , the use of mouthwash containing 1 % C recutita extract can be associated with reduced incidence , intensity , and duration of mucositis in adults patients undergoing allogenic HSCT . Implication s for Practice : The results of this investigation will help nurses and other professionals in selecting the C recutita dosage used to manage oral mucositis in patients undergoing HSCT Abstract Background Hangeshashinto ( TJ-14 , a Kampo medicine ) , which reduces the level of prostagl and in E2 and affects the cyclooxygenase activity , alleviates chemotherapy-induced oral mucositis ( COM ) . We conducted a r and omized comparative trial to investigate whether TJ-14 prevents and controls COM in patients with gastric cancer . Methods We r and omly assigned patients with gastric cancer who developed moderate-to-severe oral mucositis ( CTCAE v4.0 grade ≧1 ) during any cycle of chemotherapy to receive either TJ-14 or a placebo  as a double-blind trial . The patients received a placebo or TJ-14 for 2–6 weeks according to the chemotherapy regimen from the beginning of the next course of chemotherapy . The primary end point was the incidence of grade ≧2 oral mucositis in the protocol treatment course , and the secondary end points were the time to disappearance of oral mucositis and the incidence of adverse events . Results Following the key opening of the blinding protocol , we analyzed 91 eligible patients ( TJ-14 : 45 , placebo : 46 ) using a “ per protocol set ” analysis . The incidence of ≧ grade 2 COM was 40.0 % in the TJ-14 group and 41.3 % in the placebo group ( p = 0.588 ) . The median duration of ≧ grade 2 COM was 14 days in the TJ-14 group and 16 days in the placebo group ( p = 0.894 ) . Meanwhile , the median duration of any grade of COM was 9 days in the TJ-14 group and 17 days in the placebo group among the patients who developed grade 1 symptoms during the screening cycle [ hazard ratio 0.60 ; 95 % CI ( 0.23–1.59 ) , p = 0.290 ] . Conclusions Although TJ-14 treatment did not reduce the incidence of ≥2 COM in the patients who developed mucositis during chemotherapy for gastric cancer , a trend was observed in which TJ-14 reduced the risk of COM in the patients who developed grade 1 COM during the screening cycle . Further , phase III studies with a larger sample size are needed to clarify the protective effects of TJ-14 for COM Background : There are various drugs tried for relieving pain associated with radiation-induced mucositis . This paper aims to study role of honey in relieving pain due to radiation induced mucositis in head and neck cancer patients receiving concomitant chemoradiation . Material s and Methods : A r and omized controlled trial on 78 subjects ( 40 in test group and 38 in control group ) was undertaken to study the analgesic effect of honey , but the analysis of 69 patients was done as nine patients ( four in test and five in control group ) were lost to follow-up or left treatment in between the study . All patients were advised to do salt-soda and benzydamine mouth gargles , alternatively every 3 hours . Test group patients additionally received 20 ml honey three times a day during the entire course of radiation treatment and 3 months following radiation therapy ( RT ) . Results : Honey significantly reduced the severity of mucositis associated pain and result ed in lesser treatment gaps and a decrease in overall radiotherapy treatment duration . None of the test group and majority of controls ( 51.5 % ) had severe pain score during the 7th week of RT . The same pattern was seen in the post-RT period . Mean pain score was significantly different in both groups during all weeks during and upto 6 weeks post-RT ( mean score of 3.08 and 6.54 for test and control respectively at 7th week RT , P < 0.001 ) . Conclusion : Honey being a cheap , palatable , and natural medicament can be used for decreasing pain associated with radiation-induced mucositis in cancer patients Background Oral mucositis is one of the common complications of cancer chemotherapy and about 40 % of the patients who take chemotherapy protocol s , experience this irritating problem . The purpose of this study was to draw comparison between the therapeutic effects of our treatment modalities ( topical steroid , honey , honey plus coffee ) in patients suffering from oral mucositis . Methods This was a double blinded r and omised clinical trial of a total of 75 eligible adult participants which they r and omly fell into three treatment groups . For all the participants a syrup-like solution was prepared . Each 600 grams of the product consisted of “ 20 eight 
    Output:
    
No guideline was possible for other interventions .
Of the agents review ed in this systematic review , a guideline in favor was made for honey ( combined topical and systemic ) , while a guideline against was made for chewing gum .