***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: OBJECTIVE The aim of this study was to compare clinical outcomes of a noninvasive selective radiofrequency ( RF ) eld device ( BTL Vanquish METM , BTL Industries Inc. , Boston MA ) with its predecessor ( VanquishTM , BTL Industries Inc. , Boston MA ) . The BTL Vanquish METM system has been thoroughly re design ed for more efficient , predictable and homogenous energy delivery to the targeted tissue . MATERIAL S AND METHODS In this multi-center study , 36 subjects with BMI s under 30 were r and omly assigned to be treated in Group A ( BTL Vanquish METM ) or Group B ( VanquishTM ) in order to obtain a side by side comparison of the devices ' ef cacies . Each subject re- ceived 4 weekly 45-minute treatments with the device determined by their group assignments . Measurements of subject 's abdominal fat were taken prior to the first treatment and again four weeks after finishing the final treatment . RESULTS The primary outcome was abdominal fat thickness reduction as measured by ultrasound one month following each subject 's final treatment . Thirty four subjects completed the study . Two patients did not complete their treatments due to the reasons unrelated to the study ( one from each group ) . Subjects in Group A treated with BTL Vanquish METM had an abdominal fat thickness reduction of 4.17 mm , or 29.46 % , while subjects in Group B treated with VanquishTM had an abdominal fat thickness reduction of only 2.72 mm , or 15.21 % . The 4 weekly treatments with BTL Vanquish METM in Group A produced a 53 % higher reduction ( 4.17 mm vs 2.72 mm ) of abdominal fat layer thickness than those in Group B. The st and ard deviation of ultrasound measurements in Groups A and B were 1.42 mm and 2.21 mm , respectively . Assuming a homogenous response across the entire treatment area , the volume of fat reduced was calculated by multiplying the average measured reduction in fat layer by the surface area of the treatment applicator ( 2100 cm2 ; 325.5 square inches ) . It was calculated that Group A patients lost an average of 0.876 liter ( 0.23 liquid gallon ) of fat , while Group B patients lost 0.571 liter ( 0.15 liquid gallon ) of fat . DISCUSSION S AND CONCLUSIONS The mean difference between the tested groups was statistically significant proving better outcomes in the Vanquish METM than its predecessor . Furthermore , the reduction in st and ard deviation of fat reduction measurements in Group A vs Group B is evidence that the Vanquish METM provides more consistent performance . J Drugs Dermatol . 2016;15(12):1557 - 1561 Background : Previous studies suggest that radiofrequency ( RF ) energy may be effective as a treatment for cellulite . Objective : This bilateral paired blinded comparative study assesses the efficacy and safety of a unipolar RF device for improving the appearance of cellulite using a new quantitative cellulite grading system . Methods : In this r and omized , blinded , split‐ design study , 10 individuals ( aged 32–57 years ) with a clinical ly observable excess of subcutaneous fat and cellulite ( minimum grade 2 out of 4 ) on the thighs received up to six unilateral treatments ( number of treatments at the investigator 's discretion ) at 2‐week intervals with unipolar RF .  The untreated side of the thigh served as an internal control . Treated thighs were r and omly assigned by alternate allocation . Results were evaluated using study participant question naires and by two blinded evaluators ( JSD , KAA ) using photographs and the author 's ( MAA ) cellulite grading scale at each treatment visit and at 1‐month and 3‐month follow‐up visits after the final treatment . A novel quantitative four‐point cellulite grading system is presented and applied , which separately grade s dimple density , dimple distribution , dimple depth , diameter and contour . Results : All participants responded to treatment ( mean of 4.22 and range of three to six treatments ) . The blinded evaluations of photographs using the cellulite grading scale demonstrated the following mean grading scores for the treated leg versus the control leg : dimple density of 2.73 vs 3.18 ( 11.25 % mean improvement ) , dimple distribution 2.89 vs 3.32 ( 10.75 % mean improvement ) , dimple depth 1.47 vs 1.54 ( 2.5 % mean improvement ) , and mean score of 2.36 ( SEM 0.45 ) vs 2.68 ( SEM 0.57 ) ( 8.00±2.84 % mean improvement ) . The treatment was painless and side effects included minimal to moderate erythema which resolved within 1 to 3 hours . No crusting , scarring or dyspigmentation was observed . Conclusions : This r and omized , blinded , split‐ design , controlled study employing a quantitative four‐point grading scale demonstrated that this unipolar RF device is safe for the treatment of cellulite . Clinical ly visible and quantified improvement which did not achieve statistical significance but showed a trend toward improvement was observed in all patients following a mean of four treatments at 2‐week intervals Abstract Introduction : Skin laxity , wrinkles and cellulite are common aesthetic problems associated with the aging process . These symptoms are due to the weakening and thinning of dermal connective tissue and the enlargement of hypodermal fat cells . The aim of this study was to evaluate the safety and efficacy of the TriPollar RF technology in reducing fat and collagen regeneration . Methods : Twelve healthy patients underwent weekly treatments on different body sites using the TriPollar technology . Treatment areas were photographed and measured and patient satisfaction was monitored . One abdominal patient consented to a series of TriPollar treatments prior to her scheduled  abdominoplasty . A controlled histopathology analysis was performed on skin sample s taken during the abdominoplasty procedure . Results : Histopatho-logical examination revealed marked differences between treated and non-treated abdominal skin areas . An increase of 49 % in dermal thickness , focal thickening of collagen fibers and focal shrinkage of fat cells was shown following TriPollar treatments . Average patient satisfaction indicated clear satisfaction with the clinical results achieved . Conclusion : The TriPollar is a safe and effective non-invasive technology leading to skin tightening and body shaping . Histology results indicate changes at the dermal and fat layers following TriPollar treatments result ing in increased collagen regeneration and stimulated fat metabolism Radio frequency ( RF ) systems have been reported as producing electrothermally mediated and subcutaneous effects . The present study evaluates a new approach to treat cellulite with a bipolar RF device .  The buttocks of 50 patients were treated , 10 from each of five multinational centers with a novel bipolar RF technology set at 6 J/cm(3 ) , which changes its frequency between 0.6 and 2.4 MHz according to impedance of tissue . Twelve weekly sessions were given for 12 minutes on each buttock , with a treatment end point of 42 degrees C external skin temperature . Cellulite changes and tissue condition were assessed before and immediately after the first session , before the final 12th session , and 2 months thereafter . The patient Satisfaction Index was recorded . Objective evaluation involved clinical photography , three-dimensional optical skin surface measurement , and histological findings . Almost all patients noted improvement of cellulite and body silhouette at the final session , which slightly decreased at the 2-month assessment . Improved skin appearance was objective ly detected . Histological findings following the first session showed reactive edema and lysis of adipocyte membranes , possibly implicated in the final effects achieved . The RF technology used in the present multicenter study improved the general aspect of skin and cellulite , with high patient Satisfaction Index . Maintenance sessions might lead to even better and longer-lasting results 
    Output:
    
Clinical results suggest a positive effect of radiofrequency on the reduction in adipose tissue , proving an increase in adipocyte lipolysis .