***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Irritable bowel syndrome ( IBS ) is one of the most common functional gastrointestinal disorder which is associated with considerable sufferings of patient and Peppermint oil is volatile oil , its active principle is menthol-contain a cyclic monoterpine which has anti-spasmotic properties due to its ability to block calcium channel of intestinal smooth muscles . This study observed the efficacy of peppermint oil for relieving the symptoms and changes of quality of life ( QOL ) in diarrhea predominant IBS . This was a prospect i ve double blind r and omized placebo-controlled study conducted in the Bangab and hu Sheikh Mujib Medical University during July 2008 to September 2009 . Patients who fulfilled ROME II were initially selected but those had red flag signs or any organic disease was excluded from the study . Seventy four patients were enrolled in the study and r and omly allocated to receive either peppermint oil or placebo three times daily for six weeks . Changes of symptoms were assessed three week interval during treatment and two weeks after the end of treatment . Data were analyzed by paired and unpaired ' t ' test . Finally sixty five patients completed the trial . It was observed that , at six weeks of therapy abdominal pain is markedly improved ( mean±SD ) 4.94±1.30 in peppermint oil group compared with 6.15±1.24 in placebo group and the difference was statistically highly significant ( p>0.001 ) . But two weeks after end of trials pain score again increased ( 6.09±1.93 ) . Other symptoms and quality of life did not improve significantly . So the study result concludes that peppermint oil is effective in reliving only abdominal pain in diarrhea predominant IBS transiently In a r and omized , double-blind controlled trial , 42 children with irritable bowel syndrome ( IBS ) were given pH-dependent , enteric-coated peppermint oil capsules or placebo . After 2 weeks , 75 % of those receiving peppermint oil had reduced severity of pain associated with IBS . Peppermint oil may be used as a therapeutic agent during the symptomatic phase of IBS ABSTRACT To determine the efficacy and tolerability of an enteric-coated peppermint-oil formulation ( Colpermin ) , a prospect i ve , r and omized , double-blind , placebo-controlled clinical study was conducted in 110 out patients ( 66 men and 44 women ; 18–70 yr old ) with symptoms of irritable bowel syndrome . Patients took one capsule ( Colpermin or placebo ) 3–4 times daily , 15–30 min before meals , for 1 month . Fifty-two patients on Colpermin and 49 on placebo completed the study . Forty-one patients on Colpermin ( 79 % ) experienced an alleviation of the severity of abdominal pain ( 29 were pain free ) ; 43 ( 83 % ) had less abdominal distension , 43 ( 83 % ) had reduced stool frequency , 38 ( 73 % ) had fewer borborygmi , and 41 ( 79 % ) had less flatulence . Corresponding figures for the placebo group were : 21 patients ( 43 % ) with reduced pain ( four were pain free ) , 14 ( 29 % ) with reduced distension , 16 ( 32 % ) with reduced stool frequency , 15 ( 31 % ) with fewer borborygmi , and 11 ( 22 % ) with less flatulence . Symptom improvements after Colpermin were significantly better than after placebo ( p < 0.05 ; Mann-Whitney U-test ) . One patient on Colpermin  experienced heartburn ( because of chewing the capsules ) and one developed a mild transient skin rash . There were no significant changes in liver function test results . The authors conclude that Colpermin was effective and well tolerated . ( Am J Gastroenterol 1998;93:2304–2305 . © 1998 by Am . Coll . of Gastroenterology The incidence of imported malaria in the UK has steadily increased during the past decade , ' with 1909 cases reported in 1978 . At St Thomas 's Hospital P falciparunz malaria is much commoner than P vivax and is mostly acquired in tropical Africa.2 Most of the malaria reported in Asian immigrants is P vivax,5 and , although the World Health Organisation has reported an increase in the incidence of falciparum malaria in Bangladesh , India , and Sri Lanka , ' we have not previously seen a falciparum infection in an Asian . Chloroquineresistant falciparum malaria has been reported in South-east Asia and South America for many years , but its occurrence in the Asian subcontinent and in East Africa is much more recent . Two cases of imported chloroquine-resistant falciparum infections have recently occurred in the UK ; both were from Kenya and one was fatal.4 Our patient would appear to have shown RI resistance to chloroquine in that parasites reappeared after 23 days , although the initial course of chloroquine had apparently eradicated the infection . We made no attempt to culture the malarial parasites to confirm in-vitro resistance . This patient probably acquired her malaria from blood transfusion in Bangladesh , and there have been no reports of chloroquine-resistant P falciparum being transmitted by this route , although transfusion malaria is known to be common and underreported in the developing countries , and many cases of falciparum are described.5 Malaria in our patient was initially diagnosed by chance when blood films were being examined . The patient at this time was relatively well and afebrile , and malaria was not suspected clinical ly . The resurgence of the falciparum was unexpected and delayed diagnosis in view of the many other possible causes of fever in a neutropenic postoperative patient with leukaemia . Malaria was not initially entertained as a likely diagnosis because of the apparently successful treatment with chloroquine . It is of interest that the clinical response to intravenous quinine was slow , particularly defervescence , and perhaps " quinine fever " may have been contributory . The disappearance of parasites was also slow ; indeed , the parasitaemia appeared unchanged after two infusions of quinine . Although we are unaware of the effect of severe neutropenia and immunosuppression on the clinical course of malaria , it seems likely that this patient was infected with a chloroquine-resistant strain of P falciparum Thirty-five patients with irritable bowel syndrome were r and omized to receive treatment in a stress management programme or conventional therapy which included the antispasmodic Colpermin . The stress management programme involved a median of six 40-min sessions with a physiotherapist during which patients were helped to underst and the nature of their symptoms , their relationship to stress and were taught relaxation exercises . Two thirds of those in the stress management programme found the programme effective in relieving symptoms and experienced fewer attacks of less severity . This benefit was maintained for at least 12 months . Few of those given conventional management had any benefit . A stress management programme would appear to be of value for patients with irritable bowel syndrome 
    Output:
    
Although peppermint oil patients were significantly more likely to experience an adverse event , such events were mild and transient in nature .
The most commonly reported adverse event was heartburn .
CONCLUSIONS Peppermint oil is a safe and effective short-term treatment for IBS .