***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: OBJECTIVE The aim of this study was to monitor therapeutic response by determining the level of proinflammatory cytokines TNF-alpha and IL-6 in whole unstimulated saliva in patients with denture stomatitis ( DS ) , before and after laser phototherapy ( LPT ) . BACKGROUND DS is an inflammatory condition that occurs in subjects who wear dentures , and it is a common oral mucosal lesion . A potential noninvasive treatment for DS patients is LPT . MATERIAL S AND METHODS A sample consisting of 40 consecutive subjects was selected on a voluntary basis from patients who presented for the diagnosis and treatment of DS at the Oral Medicine Unit of the Medical Faculty at the University of Rijeka . A clinical examination was performed according to the st and ard clinical criteria . Lesions described as palatal inflammation were diagnosed as Newton type II denture stomatitis . The patients were r and omly assigned to either an experimental group ( 20 patients receiving real LPT ) or a control group ( 20 patients receiving inactive/placebo laser treatment ) . In order to determine the salivary levels of TNF-alpha and IL-6 , ELISA ( Sigma Immunochemicals , St Louis , MO ) was performed . RESULTS Following treatment with LPT for 4 wk , the levels of TNF-alpha and IL-6 decreased significantly ( p < 0.001 ) and were significantly different from controls ( p < 0.001 ) . CONCLUSION The results of this study suggest that LPT may be an efficacious choice of therapy PURPOSE This study aim ed to assess the efficacy of palatal brushing in the treatment of denture stomatitis . MATERIAL S AND METHODS After screening 143 individuals with a potential diagnosis of denture stomatitis , 48 patients ( mean age : 66.0 ± 11.2 years ) were enrolled in a two-center phase 1 clinical trial with a one-group pretest/posttest design . The intervention of interest was manual palatal brushing after each meal and before bedtime . Clinical and microbiologic examinations were performed at baseline and 1 and 3 months after treatment . Additional data were obtained using a vali date d question naire . The primary and secondary outcomes were the remission of denture stomatitis and diminution of C and ida colony-forming units ( CFUs ) , respectively . Descriptive and nonparametric statistical tests were conducted to analyze the data . RESULTS At the 3-month follow-up , denture stomatitis was completely cured in 10.4 % of the participants , and 70.8 % of denture wearers showed improvement in the clinical signs of denture stomatitis . There was a significant reduction in the area and severity of the palatal inflammation ( P < .0001 ) . The effect size ranged from medium to large ( 0.34 to 0.54 ) depending on the classification used for the diagnosis of denture stomatitis . A significant reduction in the number of C and ida CFUs isolated from the palatal mucosa and dentures ( P ≤ .05 ) was observed . CONCLUSIONS The results of this study suggest that palatal brushing is an effective treatment of denture stomatitis The etiology of denture stomatitis remains controversial . Trauma due to unstable dentures has been suggested as an etiological factor . Therefore , we tested the hypothesis that the prevalence of denture stomatitis is reduced when m and ibular dentures are stabilized by implants . Data were collected at a one-year follow-up from 173 edentulous elders who had r and omly received m and ibular implant overdentures or conventional dentures .  The diagnosis of denture stomatitis was determined according to the Newton classification . Elders wearing conventional dentures  were almost 5 times more likely to have denture stomatitis than those wearing m and ibular two-implant overdentures ( P < 0.0001 , Fisher ’s exact test ) . Adjusted odds ratios showed that only the type of the prosthesis ( AOR = 4.54 , 95 % CI 2.20 to 9.40 ) and nocturnal wear ( AOR = 3.03 , 95 % CI 1.24 to 7.40 ) predict the frequency of denture stomatitis . Thus , implant overdentures may reduce oral mucosal trauma and control denture stomatitis 
    Output:
    
In terms of method ological quality , most studies met 50 % to 80 % of STROBE criteria and were grade d B. Conclusion : Palatal inflammation in DS is significantly associated with the levels of salivary cytokines .
Knowledge Transfer Statement : The results of this study identified altered levels of specific salivary biomarkers associated with denture stomatitis , which may aid in the early diagnosis and treatment of this disease