***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Rationale Impaired emotion processing in schizophrenia predicts broader social dysfunction and has been related to negative symptom severity and amygdala dysfunction . Pharmacological modulation of emotion-processing deficits and related neural abnormalities may provide useful phenotypes for pathophysiological investigation . Objectives We used an acute benzodiazepine challenge to identify and modulate potential emotion-processing abnormalities in 20 unaffected first-degree relatives of individuals with schizophrenia , compared to 25 control subjects without a family history of psychosis . Methods An oral 1 mg dose of the short-acting anxiolytic benzodiazepine alprazolam was administered in a balanced crossover placebo-controlled double-blind design , preceding identical 3 T fMRI sessions approximately 1 week apart . Primary outcomes included fMRI activity in amygdala and related regions during two facial emotion-processing tasks : emotion identification and emotion memory . Results Family members exhibited abnormally strong  alprazolam-induced reduction in amygdala and hippocampus activation during emotion identification , compared to equal reduction in both groups for the emotion memory task . Conclusions GABAergic modulation with alprazolam produced differential responses in family members vs. controls , perhaps by unmasking underlying amygdalar and /or GABAergic abnormalities . Such pharmacological fMRI paradigms could prove useful for developing drugs targeting specific neural circuits to treat or prevent schizophrenia PURPOSE Social cognition captures affect recognition , social cue perception , " theory of mind , " empathy , and attributional style . The aim of our study was to assess social cognition in schizophrenia in patients being treated with first-generation antipsychotic drugs ( FGAs ) , n=28 ( perphenazine and haloperidol , FGAs ) or with second-generation antipsychotic drugs ( SGAs ) , n=56 ( olanzapine and clozapine , SGAs ) . SUBJECTS AND METHODS Eighty-four patients completed the Facial Expression Recognition Test , the Voice Emotion Recognition Test , the Short Recognition Memory Test for Faces , and the Reading the Mind in the Eyes Test . Patients also completed the  Visual Object and Space Perception Test ( VOSP ) as a control task , which would not engage social cognition . The patients were compared with fifty healthy controls matched for age and gender . RESULTS There were no significant differences on social cognitive performance between the FGA- and SGA-treatment groups . Nor was olanzapine superior to clozapine , FGAs or both . However , patients treated with FGAs performed significantly worse on VOSP compared to both groups treated with SGAs , a 10 % difference . CONCLUSIONS We can not conclude that SGAs were associated with better social cognition than FGAs . However , there were small but significant advantages for SGAs in non-social visual processing function , as evaluated with the VOSP 
    Output:
    
Evidence to date suggests few sex differences in FEP in schizophrenia ; both men and women across the schizophrenia spectrum have deficits in FEP