***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Plasma concentrations of amino acids are frequently elevated in insulin-resistant states , and a protein-enriched diet can impair glucose metabolism . This study examined effects of short-term plasma amino acid ( AA ) elevation on whole-body glucose disposal and cellular insulin action in skeletal muscle . Seven healthy men were studied for 5.5 h during euglycemic ( 5.5 mmol/l ) , hyperinsulinemic ( 430 pmol/l ) , fasting glucagon ( 65 ng/l ) , and growth hormone ( 0.4 microg/l ) somatostatin clamp tests in the presence of low ( approximately 1.6 mmol/l ) and increased ( approximately 4.6 mmol/l ) plasma AA concentrations . Glucose turnover was measured with D-[6,6-(2)H(2)]glucose . Intramuscular concentrations of glycogen and glucose-6-phosphate ( G6P ) were monitored using (13)C and (31)P nuclear magnetic resonance spectroscopy , respectively . A approximately 2.1-fold elevation of plasma AAs reduced whole-body glucose disposal by 25 % ( P < 0.01 ) . Rates of muscle glycogen synthesis decreased by 64 % ( 180 - -315 min , 24 plus minus 3 ; control , 67 plus minus 10 micromol center dot l(-1 ) center dot min(-1 ) ; P < 0.01 ) , which was accompanied by a reduction in G6P starting at 130 min ( DeltaG6P(260 - -300 min ) , 18 plus minus 19 ; control , 103 plus minus 33 micromol/l ; P < 0.05 ) . In conclusion , plasma amino acid elevation induces skeletal muscle insulin resistance in humans by inhibition of glucose transport/phosphorylation , result ing in marked reduction of glycogen synthesis 
    Output:
    
Based on current evidence , we found that BCAA is a useful biomarker for early detection of IR and later diabetic risk .
These factors might not only contribute to the elevated BCAA level but also show obvious associations with insulin resistance .
Genes related to BCAA catabolism might serve as potential targets for the treatment of IR associated metabolic disorders .