***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: A r and omized comparison group pretest-posttest experimental design was used to quantitatively determine the effects of environmental control measures on patients with allergic rhinitis .  Environmental controls included wrapping the mattress with a vinyl cover , washing the top bedding cover with 55 degrees C hot water every two weeks , removal of soft furniture , and wet cleaning of the bedroom floor every day .  Thirty subjects were r and omly assigned to experimental and control groups . The amount of house dust mites in dust sample s collected from the bedroom floor , bedding and mattress , as well as the nasal symptoms of patients , were measured twice at one-month intervals . A significant decrease in house dust mites in dust sample s and relief in patients ' nasal symptoms were observed in the experimental group who had environmental controls The objective of this study was to develop and test a health‐related quality of life question naire for clinical trials in rhinoconjunctivitis . The Rhinoconjunctivitis Quality of Life Question naire ( RQLQ ) was developed by asking patients to identify areas of their lives affected by rhinoconjunctivitis . The result ant RQLQ was tested for reproducibility , responsiveness and validity in a r and omized , double‐blind trial of regular versus ‘ as required ’ aqueous beclomethasone dipropionate ( BDP ) nasal spray in ragweed pollen‐induced rhinoconjunctivitis . Eighty‐five patients from previous rhinoconjunctivitis studies participated in the developmental survey . Sixty ragweed‐sensitive patients , from previous trials and media notices , were enrolled in the clinical trial . Aqueous BDP ( 800 μg ) nasal spray was administered regularly or ‘ as required ’ throughout the ragweed pollen season . The survey revealed that , in addition to local symptoms of rhinoconjunctivitis , patients experienced impairment of quality of life through systemic symptoms , sleep disturbance , practical problems , activity limitations and emotional problems . The RQLQ includes 28 questions related to these dimensions . Repeated administration of the RQLQ demonstrated good reproducibility . During the clinical trial , the RQLQ proved responsive in its ability to distinguish between regular and ‘ as required ’ medication use . Validity was shown by moderate to strong relations between changes in symptom diary scores and changes in RQLQ scores . In conclusion the RQLQ is likely to prove useful as a measure of health‐related quality of life in clinical trials in both rhinoconjunctivitis and rhinitis A double blind , r and omized , comparative study versus placebo , was done during 6 months in 32 children , aged 4 - 12 years , who suffer from either allergic asthma or rhinitis or both , slept in a bedroom rich in dust mite , have well documented allergy solely to house dust mite ( H.D.M. ) , and a condition severe enough to require continuous medication . After thorough cleaning , their bedrooms were sprayed on day 0 and day 90 with the total content of a canister containing either Acardust or Placebo . Rooms were cleaned regularly throughout the study period . Each child completed an individual daily score card ( scales from 0 - 3 ) for asthma , and rhinitis symptoms , medication taken , and any additional symptoms . Peak flow was recorded twice weekly . All the children were examined every month ( at the clinic ) when also PFF , FEVI , doctor 's and patient 's opinion of clinical symptoms were recorded according to the same scale ( 0 - 3 ) and dust sample s from child 's bedroom were examined for H.D.M. antigen content . At day 0 , 90 and 180 , total IgE and dust mite specific IgE determination was done . At the end of the study , patient 's and doctor 's opinion about the spray 's efficacy were recorded on a scale from 0 - 3 . The results were in favor of Acardust for asthma , according to patient 's opinion ( p = 0.001 ) , doctor 's opinion ( p = 0.04 ) and individual score cards ( p = 0.03 ) , and for nasal secretion ( p = 0.01 ) , sneezing and lacrimation ( p = 0.02 ) ; concurrent medication dropped significantly ( p = 0.01 ) in the Acardust group . No side-effects were reported . We consider Acardust a safe and valuable preventive treatment in H.D.M. allergy This study was design ed to assess the effectiveness of a high-efficiency particulate air ( HEPA ) filter in alleviating  allergic respiratory symptoms . Thirty-two patients were studied who had symptomatic perennial rhinitis and /or asthma during the fall and winter months and had a positive skin test with house dust or house dust -- mite extract . An ENVIRACAIRE room air cleaner was placed in the bedroom for 8 weeks . In a r and om manner , the active filter was used for 4 weeks and a blank filter for 4 weeks . There was an average 70 % reduction in the particulate matter greater than or equal to 0.3 micron with the HEPA filter . In a double-blind design , results were assessed by analysis of the patients ' symptom/medication scores and subjective evaluation . For the total study , there was no difference in the total symptom/medication scores or individual symptom scores during the placebo and active-filter periods . Analysis of the last 2 weeks of each filter period in which respiratory infection was absent demonstrated definite differences in total and individual symptoms , suggesting active-filter benefit . Patients ' subjective responses also suggested benefit from the filter . The overall impression is that the HEPA filter can reduce allergic respiratory symptoms N-(3,4-dimethoxycinnamoyl ) anthranilic acid ( N-5 ' ) , a new orally useable mast cell stabilizer , was investigated for its efficacy , safety and usefulness in the treatment of 302 patients with perennial nasal allergy by an intergroup , double-blind comparative test using disodium cromoglycate ( DSCG ) and an inactive placebo as control . The results indicated that N-5 ' , as a mild mast cell stabilizer , was comparable to DSCG in efficacy and minimum in side effect Inheritance and allergen exposure are key factors in the development and the course of atopic allergy , expressed as conjunctivitis , rhinitis , asthma or dermatitis . This study concerns the clinical significance of mite and mite‐allergen avoidance measures based on intensive cleaning with acaricide ( solidified benzylbenzoate ) added ( 10 dwellings ) , and without biocidal activity ( 10 other homes ) as a control in a double‐blind trial with matched pairs . Twenty subjects with persisting rhinitic complaints were selected . They lived in 20 different dwellings and were ail sensitized to pyroglyphid mites ; 12 of them were also sensitized to stored product miles ( Acari )  . Daily symptoms and medication score , guanine and dust exposure , total and mite‐specific IgE in serum , eosinophilia in the blood and in the nasal smear , intracutaneous tests with house dust mite and storage mite extracts were compared in both pairs and groups . Acarological data , physiochemical aspects and exposure assessment are discussed in detail elsewhere . Symptom scores dropped significantly , as did the total IgE and exposure to dust and mite products in the acaricidal cleaner treatment group . After 1 year , the daily symptoms median was 47 % ( P= 0.025 ) , total IgE was 38 % ( P=0.0049 ) , and exposure to dust and mite products ( guanine exposure ) was 53 % ( P= 0.0449 ) better or lower than in the controls . Intensive cleaning , without acaricidal treatment performed twice a year , result ed in clinical improvement in four out of 10 subjects , of whom none became free of complaints . In the Acarosan treatment group ( cleaning+ benzylbenzoate ) eight out of 10 subjcets improved , in three cases subjective symptoms disappeared . The conclusion is that mite avoidance in homes can be carried out successfully with a special acaricidal cleaning formulation Acarosan We report on the mechanisms , the environmental changes and patient compliance with regard to conventional and new dust and mite avoidance measures to prevent allergic symptoms caused by mite allergens , taking into account both allergen contamination and the developmental success of pyroglyphid Acari .  Twenty patients with persisting rhinitic complaints were selected and matched . Although the patients had performed some conventional dust and mite avoidance measures ( patient compliance was 90 % ) , the dwellings proved to be a stimulus for mite development . Moisture problems due to faulty construction and excessive moisture production were common . Since humidity conditions could not be changed at short notice , the 20 homes were subjected to the new variants of mite allergen avoidance based on intensive cleaning without ( control ) and with an acaricide incorporated ( acaricidal cleaner [ Acarosan ] ) . After the carrying out of conventional avoidance measures , these patients still had allergic symptoms , and dust from only 23 to 52 % of their textile objects was under the proposed guanine ( mite faeces indicator ) risk level . Only the acaricidal cleaner was able to decrease the allergenic mite load ( and the burden of the patients ) significantly in this 12 month period . With respect to mite‐extermination  , acaricidal cleaning was 88 % better than intensive cleaning . Reduction of guanine was 38 % better in the Acarosan treatment group 
    Output:
    
The results indicate that , when compared with controls , significant reductions of allergen load can be achieved by physical and chemical means , but there is little evidence at present that these reductions translate into sustained improvements in clinical outcomes .
No serious adverse effects were reported from the interventions