***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: BACKGROUND The fear of uncontrolled bleeding often prompts medical practitioners to stop aspirin intake for seven to 10 days before any surgical procedure . The authors initiated this study to evaluate the effect of aspirin on bleeding in patients undergoing oral surgery . METHODS The study group consisted of 39 patients who were scheduled to undergo dental extraction s. All patients were receiving 100 milligrams of aspirin daily on a regular basis . The authors r and omly divided the patients into two groups : those who stopped the aspirin therapy before the procedure and those who continued the aspirin therapy . One hour before the procedures , all patients underwent a bleeding time test . In addition , the amount of bleeding during the procedure was measured . RESULTS The mean ( + /- st and ard deviation ) bleeding time was 1.8 + /- 0.47 minutes for patients who stopped aspirin therapy one week before the procedure . For patients who continued aspirin therapy , the bleeding time was 3.1 + /- 0.65 minutes . The difference was statistically significant ( P = .004 ) . However , both groups were within the normal bleeding time range , and in both groups , a local hemostatic method was sufficient to control bleeding . No episodes of uncontrolled intraoperative or postoperative bleeding were noted . CONCLUSION Low-dose aspirin therapy should not be stopped before oral surgery . Local hemostasis is sufficient to control bleeding . CLINICAL IMPLICATION S Patients receiving aspirin therapy to prevent blood clot formation may be subject to emboli formation if the treatment is stopped . The results of this study show that aspirin therapy should be continued throughout oral surgical procedures . Local measures are sufficient to control any bleeding during surgery Discontinuation of long-term , low-dose aspirin prior to ambulatory oral surgical procedures was assessed in a blind , controlled prospect i ve study . 50 patients on low-dose aspirin who needed dental extraction s , periodontal surgery , or other ambulatory oral surgery were r and omly divided into test and control groups . The control patients stopped taking aspirin a week before operation , but in the test group aspirin was continued . Before , during and after surgery bleeding time was tested . Although bleeding time was significantly longer when aspirin was continued , in both groups it was within normal limits . Intraoperative hemorrhage was more frequent in those taking aspirin .  Hemostasis control posed no problem and there were no postoperative complications in either group . It is concluded that discontinuing low-dose aspirin prior to elective oral surgery is not justified OBJECTIVE The aim of this trial was to evaluate the bleeding after dental extraction s among patients on uninterrupted antiplatelet therapy . MATERIAL S AND METHODS A total of 190 patients under oral antiplatelet drugs requiring extraction of a single molar tooth were r and omly assigned to two groups . Group A consisted of 95 patients on uninterrupted antiplatelet therapy  and Group B consisted of 95 patients who have discontinued antiplatelet medication 5 days prior to extraction .  The bleeding time of all patients was checked prior to extraction . The surgical procedure involved simple extraction of a single molar tooth under local anesthesia . The extraction socket was sutured with 3 - 0 silk . Pressure pack with gauze was given for 1 h. Bleeding after 1 h , 24 h , 48 h , and 5 days were compared between two groups . Chi-square test was used to compare the variables . P < 0.05 was taken as significant . RESULTS None of the patients in either group had any significant uncontrollable bleeding after extraction . CONCLUSION Hence , we recommend routine single tooth extraction s in patients on long-term antiplatelet medication  , without interruption or alteration of their medication . Such patients do not have an increased risk of prolonged or excessive postoperative bleeding Our aim was to evaluate the effects of single and dual antiplatelet treatment on postoperative bleeding  in patients having dental extraction s. The prospect i ve clinical study included 160 patients who were taking antiplatelet drugs .  The first group ( n=43 ) were taking 2 drugs , mostly  aspirin and clopidogrel  , and the second group ( n=117 ) were taking a single antiplatelet drug in the form of aspirin ( n=84 ) , clopidogrel ( n=20 ) , and ticlopidine ( n=13 ) . All patients had simple dental extraction s , and local haemostasis was with resorbable collagen sponges , without suturing of the wound . The control group comprised 105 healthy subjects with a similar number of dental extraction s.  Bleeding was an " event " if it continued for more than 12h , made the patient call or return to the dental practice or emergency department , induced a large haematoma or ecchymosis within the oral soft tissues , or required blood transfusion . A total of 110 teeth were extracted on 59 occasions in the dual drug group , and 232 teeth on 128 occasions in the single drug group . Bleeding was recorded after extraction in only one patient on dual aspirin-clopidogrel treatment , which was mild and easily controlled by local haemostasis . The incidence of postoperative bleeding did not differ significantly among the three groups ( χ(2)=4.3 , p=0.11 ) . However , the wound was sutured to achieve effective initial local haemostasis in 4/59 ( 6.8 % ) and 2/128 ( 1.6 % ) occasions of tooth extraction s in the dual and single drug groups , respectively , and none in the control group ( χ(2)=10.02 , p=0.007 ) . Patients  taking single or dual antiplatelet drugs  may have teeth extracted safely without interruption of treatment using only local haemostatic measures OBJECTIVE To measure the effects of a summary -of- findings ( SoF ) table on user satisfaction , underst and ing , and time spent finding key results in a Cochrane review . STUDY DESIGN AND SETTING We r and omized participants in an evidence -based practice workshop ( r and omized controlled trial [ RCT ] I ) and a Cochrane Collaboration entities meeting ( RCT II ) to receive a Cochrane review with or without an SoF table .  In RCT I , we measured user satisfaction . In RCT II , we measured correct comprehension and time spent finding key results . RESULTS RCT I : Participants with the SoF table ( n=47 ) were more likely to " agree " or " strongly agree " that it was easy to find results for important outcomes than ( n=25 ) participants without the SoF table-68 % vs. 40 % ( P=0.021 ) . RCT II : Participants with the SoF table ( n=18 ) were more likely to correctly answer two questions regarding results than ( n=15 ) those without the SoF table : 93 % vs. 44 % ( P=0.003 ) and 87 % vs. 11 % ( P<0.001 ) . Participants with the SoF table spent an average of 90 seconds to find key information compared with 4 minutes for participants without the SoF table ( P=0.002 ) . CONCLUSION In two small trials , we found that inclusion of an SoF table in a review improved underst and ing and rapid retrieval of key findings compared with review s with no SoF table PURPOSE Acetylsalicylic acid ( ASA ) has been used for the primary and secondary prevention of cardiovascular events . To reduce bleeding , the administration of ASA has traditionally been suspended before dental procedures ; however , this suspension potentially increases the risk of thromboembolic events . The effect of ASA on the amount of bleeding that occurs during tooth extraction procedures is controversial , and perioperative guidelines recommend that ASA administration should not be altered for such procedures . The aim of this study was to evaluate the amount of bleeding that occurs during the intraoperative period of tooth extraction procedures in patients with coronary artery disease who are either undergoing acetylsalicylic acid ( ASA ) therapy or who have been instructed to suspend their ASA use . PATIENTS AND METHODS Sixty-three patients with coronary artery disease who required tooth extraction were enrolled in this study . All patients were receiving 100 mg/d of ASA  at the time of enrollment and were r and omly placed into 2 groups : group S , which was comprised of patients whose ASA therapy was suspended 7 days before tooth extraction , and group NS , comprised of patients whose ASA therapy was unaltered . A platelet aggregation test was carried out on the day of the operation , and the amount of bleeding was measured during the intraoperative period by means of aspirated blood collection . All the extraction s were performed by the same surgeon , who was unaware of whether the patient 's ASA therapy had been suspended . RESULTS The mean ( ± SD ) volume of bleeding was 12.10 ± 9.37 mL for patients who underwent ASA therapy suspension and 16.38 ± 13.54 mL for those patients whose treatments were unaltered ( P = .151 ) . Local hemostatic methods were sufficient to control bleeding , and there were no reported episodes of hemorrhaging during the intra- and postoperative periods . The platelet reactivity index values exhibited statistically significant differences between the 2 investigated groups ( P = .004 ) . The platelet reactivity index values for group S and group NS were 242.58 ± 71.26 and 192.09 ± 60.54 , respectively . CONCLUSION There was no difference in the amount of bleeding that occurred during tooth extraction between patients who continued ASA therapy versus patients who suspended their ASA therapy . The platelet reactivity test demonstrated a reduction in platelet aggregation in the ASA therapy group ( group NS ) , but this reduction was without clinical consequence 
    Output:
    
According to these findings and as bleeding is a manageable complication it seems unreasonable to undermine the APT , putting the patient in danger of a thrombotic event and its high inherent morbidity , which is n't comparable in severity and manageability to the former .