***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: The benefits of pyridoxine in the suppression of lactation were assessed in a double blind controlled trial on 175 puerperal women . No significant differences were demonstrated between pyridoxine and the placebo whether assessed by subjective discomfort or by the persistence of lactation Ninety-seven patients requiring suppression of lactation in the postpartum period were treated on a double-blind basis with bromocriptine and pyridoxine--49  patients received bromocriptine and 48 pyridoxine . A statistically significant difference between the two groups was noted , beginning after 1 day of treatment . Bromocriptine was superior to pyridoxine in the parameters measured . At the end of therapy the clinician , the midwife and the patient assessed the therapeutic efficacy of the trial drug . There was a statistically significant difference in favour of bromocriptine . Two patients treated with bromocriptine reported mild side-effects , but medication was not discontinued . In 1 patient receiving pyridoxine  side-effects were so severe that medication was discontinued -- however , the patient was already receiving the inactive tablets at this stage The efficacy of pyridoxine in the suppression of lactation has been tested in a placebo‐controlled , double‐blind trial of 253 puerperal patients . Ninety‐five per cent of the women treated with pyridoxine had their lactation successfully suppressed within one week , compared to 83 per cent for stilboestrol and 17 per cent for the placebo 
    Output:
    
WHAT IS NEW AND CONCLUSION Current evidence supporting the effectiveness of high-dose pyridoxine in the inhibition of post-partum lactation is inconsistent and insufficient .