***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: AIM The objective of the present work was to study the influence of balneo- and peloid therapy on the characteristics of the hormonal regulation in the women presenting with bacterial vaginosis . MATERIAL AND METHODS The immunoenzymatic assay ( ELISA ) was used to study characteristics of hormonal regulation in 128 women presenting with bacterial vaginosis and normal prolactin level and 58 women with bacterial vaginosis and concomitant hyperprolactinemia . The study included the evaluation of dynamics of the clinical and laboratory parameters under the influence of peloidtherapy . RESULTS The application of the sulfide-containing siltypeloids was shown to have positive clinical effect on the adrenal and ovarian function and to exert the modulating action on the levels of the pituitary and sex hormones in women with bacterial vaginosis and normal prolactin levels . In contrast , the same treatment of the women with bacterial vaginosis and hyperprolactinemia causes a further deterioration of hormonal imbalance , increases the initially elevated prolactin level , aggravates disorders in the pituitary and ovarian regulation , and decreases the effectiveness of the treatment . CONCLUSION The results of the study suggest the necessity of the differential approach to the prescription of balneo- and peloid therapy to the patients with gynecological problems associated with hormonal disorders taking into account the level of prolactinemia OBJECTIVES The objective of this study was to conduct a laser-Doppler flowmetry investigation of skin microcirculation changes induced by mud pack therapy . The magnitude of the changes , potential remote effects , and potential influence of mud pack thickness were studied . METHODS Twenty female spa therapy patients aged 28 - 67 years ( median , 51 years ) participated in the study . The reason for spa therapy was lower limb venous insufficiency in 14 patients and osteoarthritis in six patients , none of whom had involvement of the shoulders .  Mud pack treatment was associated with a significant elevation in skin temperature , by 1.8 + /- 0.2 and 1.0 + /- 0.2 degrees C with the 30- and 15-mm packs , respectively ( P < 0.001 for both comparisons ; nonsignificant difference between the two packs ) . Skin blood flow increased significantly , by 619 + /- 82 and 410 + /- 124 mV with the 30- and 15-mm packs , respectively ( P < 0.0001 for both comparisons ; nonsignificant difference between the two packs ) . The vasomotion score increased markedly on the treated side , by 16.7 + /- 2.8 and 13.0 + /- 1.6 with the 30- and 15-mm packs , respectively ( P < 0.005 for both comparisons ; no significant difference between the two packs ) . Furthermore , low-frequency vasomotion waves of a type not described previously were recorded . The microcirculatory changes lasted longer than did the temperature increase . No significant changes were noted in the other shoulder or in central body temperature . RESULTS The patients were volunteers receiving spa therapy and free of diabetes mellitus , vasoactive drug treatment , and inflammatory shoulder disease .  Two mud packs , 15 and 30 mm in thickness , respectively , were applied at an interval of 48 h , at the same time of day in a given patient , and at a distance from other spa treatments . The packs were centered on the deltopectoral groove . The side and order of application of the two packs were determined at r and om . Superficial skin blood flow was measured by laser-Doppler flowmetry ( Perimed PF4001 , wavelength 82 nm ) and recorded by the Perisoft computer program with a 3-s time constant downstream from a broadb and filter ( 12 MHz ) . CONCLUSION These results suggest that the vascular changes induced by mud pack therapy are not fully explained by vasodilation in response to local temperature elevation . Further studies are in order to identify the other mechanisms involved 
    Output:
    
Limited data suggest that muds have various properties that may explain their action on skin microbiome , with different effects on commensal and pathogenic microorganisms .