***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: The effect of karela ( Momordica charantia ) , a fruit indigenous to South America and Asia , on glucose and insulin concentrations was studied in nine non-insulin-dependent diabetics and six non-diabetic laboratory rats . A water-soluble extract of the fruits significantly reduced blood glucose concentrations during a 50 g oral glucose tolerance test in the diabetics and after force-feeding in the rats . Fried karela fruits consumed as a daily supplement to the diet produced a small but significant improvement in glucose tolerance . Improvement in glucose tolerance was not associated with an increase in serum insulin responses . These results show that karela improves glucose tolerance in diabetes . Doctors supervising Asian diabetics should be aware of the fruit 's hypoglycaemic properties Momordica charantia ( MC ) fruit was subjected to phytochemical and pharmacological interaction studies with oral hypoglycemis in NIDDM patients . Phytochemical , chromatographical analysis and extraction of methanolic MC fruit soft ( semi-solid form ) in CCl4 + C6H6 solvent system yielded 15 diverse chemical constituents -- alkaloids , glycosides , aglycone , tannin , sterol , phenol and protein . The CCl4 + C6H6 MC soft extract was used orally in a dose of 200 mg twice daily ( BD ) for pharmacological interactions with two diversely acting oral hypoglycemic agents--1 ) metformin BD and 2 ) glibenclamide BD in 15 patients of either sex ( 52 - 65 years of age ) of NIDDM . It was observed that with CCl4 + C6H6 MC soft extract plus half doses of metformin or glibenclamide or both in combination caused hypoglycemia greater than that caused by full doses used in the study with 7 days treatment . Conclusively the extract acts in synergism with oral hypoglycemics and potentiates their hypoglycemia in NIDDM Effect of Momordica charantia , a bitter vegetable popularly known as Karolla , on fasting and post pr and ial ( 2 hours after 75 gm oral glucose intake ) serum glucose levels were studied in 100 cases of moderate non-insulin dependent diabetic subjects . Drinking of the aqueous homogenized suspension of the vegetable pulp led to significant reduction ( p < 0.001 ) of both fasting and post-pr and ial serum glucose levels . This hypoglycaemic action was observed in 86 ( 86 % ) cases . Five cases ( 5 % ) showed lowering of fasting serum glucose only 
    Output:
    
There were no documentations of death from any cause , morbidity , ( health-related ) quality of life and costs .
AUTHORS ' CONCLUSIONS There is insufficient evidence to recommend momordica charantia for type 2 diabetes mellitus .