***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: OBJECTIVE To compare outcomes in psychoeducational multiple-family group treatment vs psychoeducational single-family treatment . METHOD A total of 172 acutely psychotic patients , aged 18 to 45 years , with DSM-III-R schizophrenic disorders were r and omly assigned to single- or multiple-family psychoeducational treatment  at six public hospitals in the state of New York .  Psychotic relapse , symptom status , medication compliance , rehospitalization , and employment were assessed independently during 2 years of supervised treatment . RESULTS The multiple-family groups yielded significantly lower 2-year cumulative relapse rates than did the single-family modality ( 16 % vs 27 % ) and achieved markedly lower rates in patients whose conditions had not remitted at index hospital discharge ( 13 % vs 33 % ) . The relapse hazard ratio between treatments was 1:3 . The relapse rate for both modalities was less than half the expected rate ( 65 % to 80 % for 2 years ) for patients receiving individual treatment and medication . Rehospitalization rates and psychotic symptoms decreased significantly , and medication compliance was high , to an equal degree in both modalities . CONCLUSION Psychoeducational multiple-family groups were more effective than single-family treatment in extending remission , especially in patients at higher risk for relapse , with a cost-benefit ratio of up to 1:34 This study examined family interactions associated with a failure to stabilize in schizophrenia . Fifty-eight patient and parent dyads completed a problem-solving task  soon after an acute episode . Stabilization was assessed over the following 6 months . African American patients ' self-initiated discussion s of substance use and increased anxiety during the interaction were associated with a failure to stabilize . Nonstabilization in White patients was associated with high levels of both the patients ' odd thinking and the parents ' criticism .  White patients who were depressed during the interaction were also less likely to stabilize . Findings suggest that family relationships may play in important role in determining whether patients stabilize after an acute episode . Results also point to the importance of cultural factors in predicting patient stabilization The stability of  parental expressed emotion ( EE )  is analysed over about 9 years , and related to course of illness in patients with recent-onset schizophrenia . Families , who participated in a 15-month intervention , were r and omised over two intervention conditions . Psychotic episodes were measured over 5 years after discharge . The Five Minute  Speech Sample ( FMSS ) EE was elicited two times during the 12-month outpatient intervention and two times over 8 years after discharge on average . EE is expressed as criticism/dissatisfaction ( CRIT ) , emotional overinvolvement ( EOI ) , and as the classical dichotomous index . EE is not stable over the years . Intervention condition had no differential effect on EE as measured with CRIT and the dichotomous index . For EOI , an interaction between intervention condition and time was found . EE as assessed during intervention does not predict psychotic episodes during follow-up . An association was found between psychotic episodes and CRIT as assessed at 34 months after discharge . Family intervention may inhibit the development of high EOI for a limited period . Our results may be in support of the hypothesis that psychotic episodes in patients can affect the critical attitude in parents 
    Output:
    
However , our findings suggest that the construct and measurement of EOI itself are culture-specific .
EOI may not necessarily be detrimental in all cultures .
The effect of high EOI may be moderated by the unexplored dimension of warmth and high levels of mutual interdependence in kin relationships .