***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: BACKGROUND Interventions including physical exercise may help improve the outcomes of late-life major depression  , but few studies are available . AIMS To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression  . METHOD Primary care patients ( 465 years ) with major depression were r and omised to 24 weeks of higher-intensity , progressive aerobic exercise plus sertraline ( S+PAE ) , lower-intensity , non-progressive exercise plus sertraline ( S+NPE ) and sertraline alone . The primary outcome was remission ( a score of ≤10 on the Hamilton Rating Scale for Depression ) . RESULTS A total of 121 patients were included . At study end , 45 % of participants in the sertraline group , 73 % of those in the S+NPE group and 81 % of those in the S+PAE group achieved remission ( P = 0.001 ) . A shorter time to remission was observed in the S+PAE group than in the sertraline-only group . CONCLUSIONS Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression BACKGROUND Exercise is a potential treatment for depression . However , few studies have evaluated the role of adjunct exercise in the treatment of severely major depressed in patients . The goal of this study was to evaluate the effects of add-on exercise on the usual treatment of severely depressed in patients . METHODS Fifty participants were r and omized to an exercise ( exercise + usual treatment ) or a control ( usual treatment ) group . Twenty-five patients were r and omly allocated to each group . The participants in the exercise group performed three sessions per week throughout the hospitalization period , with a goal dose of 16.5 kcal/kg/week plus the usual pharmacological treatment . Depressive symptoms and the Quality of Life ( QoL ) of the participants were assessed at the baseline , the second week , and discharge . RESULTS A significant group × time interaction was found for depressive symptoms and the physical and psychological domains of QoL. Differences between groups occurred at the second week and discharge with respect to depressive symptoms and the physical and psychological domains of QoL. There was no difference in the remission rate at discharge ( 48 % and 32 % for the exercise and control group , respectively ) . An NNT of 6.25 was found . No significant baseline characteristics predict remission at discharge . CONCLUSION Add-on exercise is an efficacious treatment for severely depressed in patients , improving their depressive symptoms and QoL. Initial acceptance of exercise remains a challenge INTRODUCTION TV viewing is the most prevalent sedentary behavior and is associated with increased risk of cardiovascular disease and cancer mortality , but the association with other leading causes of death is unknown . This study examined the association between TV viewing and leading  causes of death in the U.S. METHODS A prospect i ve cohort of 221,426 individuals ( 57 % male ) aged 50 - 71 years who were free of chronic disease at baseline ( 1995 - 1996 ) , 93 % white , with an average BMI of 26.7 ( SD=4.4 ) kg/m(2 ) were included . Participants self-reported TV viewing at baseline and were followed until death or December 31 , 2011 . Hazard ratios ( HRs ) and 95 % CIs for TV viewing and cause-specific mortality were estimated using Cox proportional hazards regression . Analyses were conducted in 2014 - 2015 . RESULTS After an average follow-up of 14.1 years , adjusted mortality risk for a 2-hour/day increase in TV viewing was significantly higher for the following causes of death ( HR [ 95 % CI ] ) : cancer ( 1.07 [ 1.03 , 1.11 ] ) ; heart disease ( 1.23 [ 1.17 , 1.29 ] ) ; chronic obstructive pulmonary disease ( 1.28 [ 1.14 , 1.43 ] ) ; diabetes ( 1.56 [ 1.33 , 1.83 ] ) ; influenza/pneumonia ( 1.24 [ 1.02 , 1.50 ] ) ; Parkinson disease ( 1.35 [ 1.11 , 1.65 ] ) ; liver disease ( 1.33 [ 1.05 , 1.67 ] ) ; and suicide ( 1.43 [ 1.10 , 1.85 ] . Mortality associations persisted in stratified analyses with important potential confounders , reducing causation concerns . CONCLUSIONS This study shows the breadth of mortality outcomes associated with prolonged TV viewing , and identifies novel associations for several leading causes of death . TV viewing is a prevalent discretionary behavior that may be a more important target for public health intervention than previously recognized . TRIAL REGISTRATION Clinical Trials.gov number , NCT00340015 Aerobic exercise training is considered an adequate complementary treatment strategy for major depressive disorder ( MDD ) . However , there is a need for comparative method ological investigations to determine the appropriate exercise intensity for these patients . The study compared submaximal exercise intensity determination with those derived from maximal parameters such as percentages of heart rate reserve ( HRR ) , maximal heart rate ( HR(max ) ) and peak oxygen uptake ( VO(2peak ) ) of patients and controls . An exhaustive incremental bicycle exercise test was completed by 15 female MDD patients and matched controls . The  individual anaerobic lactate threshold ( IAT ) as a gold st and ard to determine individual aerobic exercise intensity was assessed according to Stegmann and coworkers . Exercise intensities at 70 and 85 % of HR(max ) , 70 and 85 % of HRR and 50 to 80 % of VO(2peak ) were compared to the IAT . Patients suffering from MDD switched earlier to anaerobic metabolism than matched healthy controls . But interestingly , the level of self-rated perceived exertion , concentration of lactate , respiratory exchange ratio and heart rate at the IAT level revealed no significant difference between both groups . Due to a growing number of clinical aerobic exercise treatments in depressive disorders exercise intensities > 70 % of ( a ) HR(max ) , ( b ) HRR , ( c ) VO(2peak ) should be amended by the IAT and Borg scale measurements to avoid over challenging as well as increased anaerobic metabolism INTRODUCTION There is an increasing amount of evidence showing that  physical activity  and  sun exposure  are effective coadjuvant treatments for patients with mild to moderate depression . However , there is a lack of information regarding patient 's adherence to these recommendations in daily clinical practice . METHODS We conducted a study including 15 depressive patients who had been under antidepressant treatment for at least one month . They wore a wrist-watch-like actimetry sensor to measure physical activity and sun exposure 24 hours a day . After one week of baseline assessment , patients were r and omised into one of the two arms of the study . Patients in the experimental group received a brief note in which they were explicitly asked to increase both their physical activity level and time of sun exposure , while control group patients did not receive these explicit recommendations . RESULTS One week after recommendations were delivered , only patients in the experimental group had increased time of sun exposure and physical activity ( 25.8 % and 14.3 % , respectively ) . CONCLUSIONS Depressive patients are able to follow prescribed lifestyle recommendations in the short-term BACKGROUND The present review systematic ally evaluates correlates of physical activity across the socio-ecological model for people with depression . SUBJECTS AND METHODS Two independent review ers search ed Embase , PubMed , and CINAHL from their inception until May 2015 , combining the medical subject heading ' depression ' or ' depressive ' with ' physical activity ' or ' exercise ' . Data were extracted by the same independent research ers and summarized according to the socio-ecological model . RESULTS Fifty-nine papers involving 101,539 persons with depression were eligible and enabled us to evaluate 42 correlates . Correlates that were consistently ( n ≥ 4 ) associated with lower physical activity participation in depressed persons were a higher level of depressive symptoms , a higher body mass index , the presence of physical co-morbidity and a lower self-efficacy . The role of social , environmental and policy factors on  physical activity participation is unknown and should be addressed in future research . CONCLUSION In persons with depression  physical activity participation  is a complex behavior that is influenced by many different factors . Significant correlates should be confirmed in prospect i ve studies . Interventions to improve modifiable physical and mental health variables in people with depression should be developed and evaluated 
    Output:
    
CONCLUSIONS Adults with MDD engage in low levels of PA and high levels of SB .