***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: PURPOSE Comparison of quality of life ( QoL ) and side effects in a r and omized trial for early hyperbaric oxygen therapy ( HBOT ) after  radiotherapy ( RT ) . METHODS AND MATERIAL S From 2006 , 19 patients with tumor originating from the tonsillar fossa and /or soft palate ( 15 ) , base of tongue ( 1 ) , and nasopharynx ( 3 ) were r and omized to receive HBOT or not . HBOT consisted of 30 sessions at 2.5 ATA ( 15 msw ) with oxygen breathing for 90 min daily , 5 days per week , applied shortly after the RT treatment was completed . As of 2005 , all patients received vali date d question naires ( i.e. , the European Organization for Research and Treatment of Cancer [ EORTC ] QLQ-C30 , EORTC QLQ Head and Neck Cancer Module ( H&N35 ) , Performance Status Scale ) : before treatment ; at the start of RT treatment ; after 46 Gy ; at the end of RT treatment ; and 2 , 4 , and 6 weeks and 3 , 6 , 12 , and 18 months after follow-up . RESULTS On all QoL items , better scores were obtained in patients treated with hyperbaric oxygen . The difference between HBOT vs. non-HBOT was significant for all parameters : EORTC H&N35 Swallowing ( p = 0.011 ) , EORTC H&N35 Dry Mouth ( p = 0.009 ) , EORTC H&N35 , Sticky Saliva ( p = 0.01 ) , PSS Eating in Public ( p = 0.027 ) , and Pain in Mouth ( visual analogue scale ; p < 0.0001 ) . CONCLUSIONS Patients r and omized for receiving hyperbaric oxygen after the RT had better QoL scores for swallowing , sticky saliva , xerostomia , and pain in mouth Although hyperbaric oxygen is used to treat chronic radiation tissue injury , clinical evidence supporting its efficacy has been limited to date . The authors report prospect ively collected patient outcomes from a single center 's large experience using hyperbaric oxygen to treat chronic radiation injury The aim of this study was to evaluate the effect of hyperbaric oxygen therapy ( HBOT ) on microvascular tissue and cell proliferation in the oral mucosa . Twenty patients , aged 51 - 78 years , were allocated r and omly to a treatment or a control group . All had a history of radiotherapy ( 50 - 70 Gy ) to the orofacial region 2 - 6 years previously . Tissue sample s were taken from the irradiated buccal oral mucosa before HBOT and at 6 months after treatment . In the control group , tissue sample s were taken on two occasions , 6 months apart . The sample s were subjected to immunohistochemistry staining : double staining with CD31 and D2 - 40 for microvessels , or Ki-67 for the analysis of cell proliferation . Blood vessel density and area were significantly increased after HBOT ( P=0.002 - 0.041 ) . D2 - 40-positive lymphatic vessels were significantly increased in number and area in the sub-epithelial area ( P=0.002 and P=0.019 , respectively ) . No significant differences were observed in the control group . There were no significant differences in Ki-67-expressing epithelial cells between the two groups . It is concluded that the density and area of blood and lymphatic vessels in the irradiated mucosa are increased by HBOT 6 months after therapy . Epithelial cell proliferation is not affected by HBOT Surgical treatment of malignancies in the oral cavity and subsequent radiotherapy often result in an anatomic and physiological oral condition unfavorable for prosthodontic rehabilitation . The objective of this prospect i ve study was to assess the effect of hyperbaric oxygen therapy on treatment outcome ( condition of peri-implant tissues , implant survival , oral functioning and quality of life ) of prosthodontic rehabilitation with implant-retained lower dentures in radiated head and neck cancer patients 6 weeks and 1 year after placing the new dentures . The treatment outcome was assessed in a group of 26 head neck cancer patients who were subjected to radiotherapy after tumour surgery .  St and ardized question naires were completed and clinical and radiographic assessment s were performed . After r and omization , endosseous Brånemark implants were placed in the anterior part of the m and ible either under antibiotic prophylaxis ( 13 patients ) or under antibiotic prophylaxis combined with pre and postsurgery hyperbaric oxygen ( HBO ) treatment ( 13 patients ) . In the HBO and non-HBO group eight implants ( implant survival 85.2 % ) and three implants ( implant survival 93.9 % ) were lost , respectively . Peri-implant tissues had a healthy appearance in both groups . Osteoradionecrosis developed in one patient in the HBO group . All patients functioned well with their implant-retained lower denture . The quality of life related to oral functioning and denture satisfaction were improved to a comparable extent in the HBO and non-HBO group . Implant-retained lower dentures can improve the quality of life related to oral functioning and denture satisfaction in head and neck cancer patients . Adjuvant hyperbaric oxygen therapy could not be shown to enhance implant survival in radiated m and ibular jaw bone Significant challenges are faced by the oral and and a variety of donor sites available to the surgical maxillofacial reconstructive surgeon . As health care professionals , we are in a constant search for excellence in patient care , education , and research . The objective of this issue of the Oral and Maxillofacial Surgery Clinics of North America is to address the needs of a continually evolving specialty , combined with the stated goal of expected excellence . Rehabilitation of the facial structures is a complex task . Optimal treatment requires the achievement of multiple reconstructive goals : oral competence , effective mastication , functional deglutition , preservation of speech , and an acceptable cosmetic appearance . When we assess the cosmetic needs of a patient , we should address symmetry , color , texture , strength , sensibility , and motor innervation of the tissues to be replaced . Appropriate choice of the harvest site is key in the decision process . We can reach these stated objectives through a systematic prospect i ve analysis by using outcome measures . The goal of academic surgery is to translate research into education and delivery of care . Successful clinical outcomes can be applied to maximize patient management . The success of translational research in the area of reconstruction has result ed in a plethora of Purpose : Analysis of the feasibility and effect of hyperbaric oxygen treatment ( HBO ) on cognitive functioning in patients with cognitive disorders after irradiation of the brain . Patients and Method : Seven patients with cognitive impairment after brain irradiation , with an interval of at least 1.5 years after treatment , were treated with 30 sessions of HBO in a phase I – II study . A comprehensive neuropsychological test battery was performed before treatment , at 3 and 6 months thereafter . Patients were r and omized into an immediate treatment group and a delayed treatment group . The delayed group had a second neuropsychological test at 3 months without treatment in that period and started HBO thereafter . Results : All eligible patients completed the HBO treatment and the extensive neuropsychological testing . One out of seven patients had a meaningful improvement in neuropsychological functioning . At 3 months there was a small , but not significant benefit in neuropsychological performance for the group with HBO compared to the group without HBO treatment . Six out of seven patients eventually showed improvement after HBO in one to nine ( median 2.5 ) of the 31 tests , although without statistical significance . Conclusion : HBO treatment was feasible and result ed in a meaningful improvement of congitive functioning in one out of seven patients . Overall there was a small but not significant improvement . Hintergrund : Es wurden die Durchführbarkeit und Wirksamkeit der hyperbaren Oxygenierung ( HBO ) auf die Gehirnfunktion bei Patienten mit kognitiven Störungen nach Hirnbestrahlung untersucht . Patientengut und Method e : In einer Phase-I/II-Studie wurden sieben Patienten mit kognitiven Störungen nach einem minimalen Intervall von 1,5 Jahren 30 HBO-Beh and lungen unterzogen . Neuropsychologische Tests wurden vor HBO sowie 3 und 6 Monate nach Abschluss der Beh and lung durchgeführt . Patienten wurden r and omisiert in eine sofortige und eine späte Beh and lungsgruppe . Die späte Beh and lungsgruppe wurde nach 3 Monaten zum zweiten Mal neuropsychologisch getestet ohne zwischenzeitliche HBO-Beh and lung . Nach diesem zweiten Test begann in dieser Gruppe die HBO . Ergebnisse : Alle Patienten konnten die vorgeschriebene HBO-Therapie und das umfangreiche neuropsychologische Testprogramm abschließen . Einer von sieben Patienten zeigte eine bedeutsame Verbesserung der neuropsychologischen Funktion . Die HBO-Gruppe zeigte i m Vergleich zu einer nicht mit HBO beh and elten Kontrollgruppe nach 3 Monaten eine leichte , statistisch nicht signifikante Verbesserung . Bei sechs der insgesamt sieben HBO-Patienten waren Verbesserungen nachweisbar in einem bis neun ( median 2,5 ) der 31 Tests , die statistisch jedoch nicht signifikant waren . Schlussfolgerung : HBO ist bei Patienten nach Hirnbestrahlung durchführbar und erzielte bei einem von sieben Patienten eine bedeutsame Verbesserung der kognitiven Funktion . Insgesamt zeigte sich eine leichte , statistisch nicht signifikante Verbesserung der getesteten Hirnfunktionen AIM to evaluate the influence of HBOT to the side effect and quality of life  after pelvic radiation . METHODS this is an open r and omized , parallel , prospect i ve study conducted in Department of Obstetrics and Gynecology , Oncology Division and Department of Radiotherapy . Endoscopy procedure was performed in Department of Internal Medicine and tissue biopsy in Department of Pathology Anatomy . The hyperbaric oxygen therapy ( HBOT ) was done in Dr. Mintohardjo , Navy Seal Hospital Jakarta . The side effect was measured using LENT SOMA scale ratio , the quality of life used the Karnofsky score . The difference of two mean was analyzed using student t test . RESULTS of 32 patients undergoing HBOT and 33 patients as control , the ratio of ASE of control group was 44.1+/-28.2 % , HBOT group was 0.7+/-30.1 % ; p<0.001 ; the LSE of control group was 33.6+/-57.6 % , HBOT group was -19.6+/-69.4 % ; p=0.008 . Quality of life of control group after intervention was 4.5+/-10.7 % ; HBOT group was 19.7+/-9.6 % ; p < 0.001 . After 6 months of intervention the quality of life was 2.5+/-16.1 % in the control group , and HBOT group was 15.2+/-14.7 % ; p = 0.007 . CONCLUSION the study showed that HBOT decreased acute and late side effect , also improved the quality of life of patients with proctitis radiation The aim of this study was to evaluate the effect of hyperbaric oxygen therapy ( HBOT ) on vascular function and tissue oxygenation in irradiated facial skin and gingival mucosa . Twenty-two patients , aged 51 - 90 years , were r and omly allocated to a treatment or control group . All had a history of radiotherapy ( 50 - 70 Gy ) to the orofacial region 2 - 20 years previously .  Skin and mucosal perfusion were recorded with laser Doppler flowmetry ( LDF ) . Tissue oxygenation was recorded by transcutaneous oximetry ( TcPO(2 ) ) . Measurements were taken before HBOT and 3 and 6 months after a mean of 28 HBOT sessions ( partial pressure of oxygen of 240 kPa for 90 min ) . For control subjects , measurements were taken on two occasions 6 months apart . After HBOT , blood flow in mucosa and skin after heat provocation increased significantly ( P < 0.05 ) . TcPO(2 ) increased significantly in the irradiated cheek ( P < 0.05 ) , but not at reference points outside the field of radiation . There were no differences between the 3- and 6-month follow-ups . In the control group , no significant changes in LDF or TcPO(2 ) were observed . It is concluded that oxygenation and vascular capacity in irradiated facial skin and gingival mucosa are increased by HBOT . The effects persist for at least 6 months PURPOSE Persisting symptomatology after breast-conserving surgery and radiation is frequently reported . In most cases , symptoms in the breast resolve without further treatment . In some instances , however , pain , erythema , and edema can persist for years and can impact the patient 's quality of life . Hyperbaric oxygen therapy was shown to be effective as treatment for late radiation sequelae . The objective of this study was to assess the efficacy of hyperbaric oxygen therapy in symptomatic patients after breast cancer treatment . PATIENTS AND METHODS Forty-four patients with persisting symptomatology after breast-conservation therapy were prospect ively observed . Thirty-two women received hyperbaric oxygen therapy in a multiplace chamber for a median of 25 sessions ( range , 7 - 60 ) . One hundred percent oxygen was delivered at 240 kPa for 90-min sessions , 5 times per week . Twelve control patients received no further treatment . Changes throughout the irradiated breast tissue were scored prior to and after hyperbaric oxygen therapy 
    Output:
    
These small trials suggest that for people with LRTI affecting tissues of the head , neck , anus and rectum , HBOT is associated with improved outcome .
HBOT also appears to reduce the chance of ORN following tooth extraction in an irradiated field .
There was no such evidence of any important clinical effect on neurological tissues .
The application of HBOT to selected participants and tissues may be justified .