***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Little is known about the involvement of saliva in gingival overgrowth ( GO ) . It was hypothesized that , in this situation , the composition of saliva is altered . Thus , proteins , albumin , cytokines , and growth factors in whole and gl and ular saliva were investigated . Differences between gl and ular and gingival contributions to the composition of saliva were explored in patients medicated with cyclosporin who exhibited GO ( responders ) , those without GO ( non-responders ) , and non-medicated subjects ( controls ) . In whole saliva , interleukin-1α ( IL-1α ) , IL-6 , IL-8 , epidermal growth factor ( EGF ) , nerve growth factor ( NGF ) , and albumin were detected , but in gl and ular saliva only EGF and NGF were identified . Albumin and IL-6 differed significantly between responders and controls , although the overall profile of salivary proteins remained unchanged . Thus , inflammatory cytokines and albumin are confined to whole saliva and are associated with GO , whereas its content of EGF and NGF appears unaffected by cyclosporin Transforming growth factor-beta 1 ( TGF-beta 1 ) plays an important role in the modulation of cellular growth and differentiation and the production and degradation of the extracellular matrix . A number of experimental results suggest that TGF-beta 1 may be involved in cardiovascular physiopathology . In the present study , we assessed whether the TGF-beta 1 gene is a c and i date gene for coronary heart disease or hypertension . We screened the coding region and 2181 bp upstream of the TGF-beta gene for polymorphisms and identified seven polymorphisms : 3 in the upstream region of the gene at positions -988 , -800 , and -509 from the first transcribed nucleotide ; 1 in a nontranslated region at position + 72 ; 2 in the signal peptide sequence Leu10 - ->Pro , Arg25 - ->Pro ; and 1 in the region of the gene coding for the precursor part of the protein not present in the active form , Thr263 - ->Ile . We analyzed these TGF-beta 1 polymorphisms in 563 patients with myocardial infa rct ion and 629 control subjects from four regions in Northern Irel and and France . The Pro25 allele was more frequent in patients than in control subjects in Belfast ( P < .01 ) and Strasbourg ( P < .05 ) . The TGF-beta 1 polymorphisms were not associated with the degree of angiographically assessed coronary artery disease in patients . The presence of a Pro25 allele was associated with a lower systolic pressure in the four control groups ( P < .002 ) , and a history of hypertension was significantly less frequent in homozygotes or heterozygotes for Pro25 than in hormozygotes for Arg25 ( odds ratio , 0.43 , 95 % confidence interval , 0.19 to 0.92 ; P < .03 ) . Since the Pro25 allele was associated with an increased risk of myocardial infa rct ion and a reduced risk of hypertension , we favor a cautious interpretation of these apparently inconsistent results . Other studies will need to verify whether these associations are real 
    Output:
    
Our meta- analysis has found the haplotype of TGFB1 codon 10/25 T/T G/G and T/C G/G genotypes , associated with increased production of TGF-β1 , was linked with CAD risk following kidney transplantation .
Moreover , no significant difference was found between TGFB1 codon 10 or codon 25 and the development of CAD