***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Background : It has been shown that camel milk consumption has a definite decreasing effect on the prevalence of diabetes . However , most of these studies were conducted on patients with type 1 diabetes , whereas studies on patients with type 2 diabetes mellitus ( T2DM ) are limited . In vitro experiments have shown that camel milk was able to decrease blood glucose concentration . Objectives : The purpose of this study was to investigate effects of camel and cow milk on blood sugar , lipid profile , and blood pressure of patients with T2DM . Patients and Methods : In a r and omized single-blinded controlled clinical trial , 20 patients with T2DM were r and omly allocated into two groups . Participants consumed 500 mL of either camel milk ( intervention group ) or cow milk ( control group ) daily for two months . Results : Mean of insulin concentration was significantly increased from 64.59 to 84.03 pmol/L in the camel milk group during the study ( P < 0.05 ) . No significant differences were shown in fasting blood sugar , lipid profile , and blood pressure between the two groups at the end of study . There was significant increase in homeostasis model assessment of insulin resistance ( HOMA-IR ) during the study in both groups , but no significant difference was seen between the two groups . Conclusions : Camel milk increased insulin level in patients with T2DM and might contribute to glycemic control in T2DM Diabetic nephropathy is originally microvascular in nature and is widely considered an important complication of diabetes . The present study was carried out to determine the efficacy of camel milk in controlling diabetic nephropathy .  Twenty-four type-1 diabetic patients were r and omly recruited from the outpatient diabetic clinic in PBM Hospital , Bikaner , India . All subjects gave their written consent before participation in the study . Patients with any acute metabolic complications were not included in the study . Eligible patients entered a run-in period of 1 month in which they were oriented to achieve the best possible glycemic control through st and ardized diet , st and ardized exercise regimen and insulin administration . During this period frequent monitoring of blood sugar was performed to maintain euglycemia . At the end of the run-in period , a base line evaluation was performed , then these patients were given camel milk in addition with usual care for six months .  Urine microalbumin and blood sugar was measured twice a week before breakfast and dinner . There was a significant improvement in the microalbuminuria ( 119.48 + /- 1.68 to 22.52 + /- 2.68 ; p < 0.001 ) after receiving camel milk for 6 months . A significant reduction in the mean dose of insulin for obtaining glycemic control was achieved ( 41.61 + /- 3.08 to 28.32 + /- 2.66 ; p < 0.01 ) . This study was performed to observe the role of camel milk in controlling microalbuminuria levels in type-1 diabetic patients . It was observed that after adding camel milk to the usual regimen an improvement in microalbuminuria was reached ( 119.48 + /- 1.68 to 22.52 + /- 2.68 ; p < 0.001 ) . This may be due to good glycemic control or to the direct effect of camel milk . The mechanism behind this effect is still unknown Background / Objectives : Hypoglycemic effect of camel milk supplementation in experimental rat model and significant reduction in doses of insulin in type 1 diabetic patients have been observed in our previous studies . This long-term study was undertaken to assess the efficacy , safety and acceptability of camel milk as an adjunct to insulin therapy in type 1 diabetics . Subjects/ Methods : In this 2-year r and omized clinical , parallel design study , 24 type 1 diabetics were enrolled and divided into two groups . Group I ( n=12 ) received usual care , that is , diet , exercise and insulin and Group II ( n=12 ) received 500 ml camel milk in addition to the usual care . Insulin requirement was titrated weekly by blood glucose estimation . Results were analyzed by using the regression technique . Results : In camel milk group , there was decrease in mean blood glucose ( 118.58±19–93.16±17.06 mg/dl ) , hemoglobin A1c levels ( 7.81±1.39–5.44±0.81 % ) and insulin doses ( 32.50±9.99–17.50±12.09 U/day , P<0.05 ) . Out of 12 subjects receiving camel milk , insulin requirement in 3 subjects reduced to zero . There was nonsignificant change in plasma insulin and anti-insulin antibodies in both the groups . Conclusion : It may be stated that camel milk is safe and efficacious in improving long-term glycemic control , with a significant reduction in the doses of insulin in type 1 diabetic patients Most systematic review s rely substantially on the assessment of the method ological quality of the individual trials . The aim of this study was to obtain consensus among experts about a set of generic core items for quality assessment of r and omized clinical trials ( RCTs ) . The invited participants were experts in the field of quality assessment of RCTs . The initial item pool contained all items from existing criteria lists . Subsequently , we reduced the number of items by using the Delphi consensus technique . Each Delphi round comprised a question naire , an analysis , and a feedback report . The feedback report included staff team decisions made on the basis of the analysis and their justification . A total of 33 international experts agreed to participate , of whom 21 completed all question naires . The initial item pool of 206 items was reduced to 9 items in three Delphi rounds . The final criteria list ( the Delphi list ) was satisfactory to all participants . It is a starting point on the way to a minimum reference st and ard for RCTs on many different research topics . This list is not intended to replace , but rather to be used alongside , existing criteria lists There is a traditional belief in the Middle East that regular consumption of camel milk may aid in prevention and control of diabetes . The aim of this work was to evaluate the efficacy of camel milk as an adjuvant therapy in young type 1 diabetics . This 16-week r and omized study enrolled 54 type 1 diabetic patients ( average age 20 years ) selected from those attending the outpatient diabetes clinic of the Menofia University Hospital , affiliated with Egypt 's National Cancer Institute . Subjects were r and omly divided into two groups of 27 patients : one received usual management ( diet , exercise , and insulin ) , whereas the other received 500 mL of camel milk daily in addition to st and ard management . A control group of 10 healthy subjects was also assessed . The following parameters were evaluated at baseline and at 4 and 16 weeks : hemoglobin A1c ( HbA1c ) , human C-peptide , lipid profile , serum insulin , anti-insulin antibodies , creatinine clearance , albumin in 24-hour urine , body mass index , and Diabetes Quality of Life score . The following parameters were significantly different between the usual-management group versus the camel milk group after 16 weeks : fasting blood sugar ( 227.2 + /- 17.7 vs. 98.9 + /- 16.2 mg/dL ) , HbA1c ( 9.59 + /- 2.05[% ] vs. 7.16 + /- 1.84[% ] ) , serum anti-insulin antibodies ( 26.20 + /- 7.69 vs. 20.92 + /- 5.45 microU/mL ) , urinary albumin excretion ( 25.17 + /- 5.43 vs. 14.54 + /- 5.62 mg/dL/24 hours ) , daily insulin dose ( 48.1 + /- 6.95 vs. 23 + /- 4.05 units ) , and body mass index ( 18.43 + /- 3.59 vs. 24.3 + /- 2.95 kg/m(2 ) ) . Most notably , C-peptide levels were markedly higher in the camel milk group ( 0.28 + /- 0.6 vs. 2.30 + /- 0.51 pmol/mL ) . These results suggest that , as an adjunct to st and ard management , daily ingestion of camel milk can aid metabolic control in young type 1 diabetics , at least in part by boosting endogenous insulin secretion 
    Output:
    
Most of the studies in the current systematic review demonstrated the favorable effects of camel milk on diabetes mellitus by reducing blood sugar , decreasing insulin resistance and improving lipid profiles