***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Animal and human data indicate a role for the peroxisome proliferator-activated receptor-gamma coactivator 1alpha ( PPARGC1A ) gene product in the development of maximal oxygen uptake ( V(O2 max ) ) , a determinant of endurance capacity , diabetes , and early death . We tested the hypothesis that the frequency of the minor Ser482 allele at the PPARGC1A locus is lower in World-class Spanish male endurance athletes ( cases ) [ n = 104 ; mean ( SD ) age : 26.8 ( 3.8 ) yr ] than in unfit United Kingdom ( UK ) Caucasian male controls [ n = 100 ; mean ( SD ) age : 49.3 ( 8.1 ) yr ] . In cases and controls , the Gly482Ser genotype met Hardy-Weinberg expectations ( P > 0.05 in both groups tested separately ) . Cases had significantly higher V(O2 max ) [ 73.4 ( 5.7 ) vs. 29.4 ml x kg(-1 ) x min(-1 ) ( 3.8 ) ; P < 0.0001 ] and were leaner [ body mass index : 20.6 ( 1.5 ) vs. 27.6 kg/m2 ( 3.9 ) ; P < 0.0001 ] than controls . In unadjusted chi2 analyses , the frequency of the minor Ser482 allele was significantly lower in cases than in controls ( 29.1 vs. 40.0 % ; P = 0.01 ) . To assess the possibility that genetic stratification could confound these observations , we also compared Gly482Ser genotype frequencies  in Spanish ( n = 164 ) and UK Caucasian men ( n = 381 ) who were unselected for their level of fitness . In these analyses , Ser482 allele frequencies were very similar ( 36.9 % in Spanish vs. 37.5 % in UK Caucasians , P = 0.83 ) , suggesting that confounding by genetic stratification is unlikely to explain the association between Gly482Ser genotype and endurance capacity . In summary , our data indicate a role for the Gly482Ser genotype in determining aerobic fitness . This finding has relevance from the perspective of physical performance , but it may also be informative for the targeted prevention of diseases associated with low fitness such as Type 2 diabetes 
    Output:
    
PPARs can be used for estimating the potential to achieve elite status in human physical performance in strength and power , team , and aerobic sports disciplines .
Carrying specific PPAR alleles can provide a partial benefit to achieving elite sports status , but does not preclude achieving elite status if they are absent