***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: The Global Asthma Network ( GAN ) , established in 2012 , followed the International Study of Asthma and Allergies in Childhood ( ISAAC ) . ISAAC Phase One involved over 700 000 adolescents and children from 156 centres in 56 countries ; it found marked worldwide variation in symptom prevalence of asthma , rhinitis and eczema that was not explained by the current underst and ing of these diseases ; ISAAC Phase Three involved over 1 187 496 adolescents and children ( 237 centres in 98 countries ) . It found that asthma symptom prevalence was increasing in many locations especially in low- and middle-income countries where severity was also high , and identified several environmental factors that required further investigation . GAN Phase I , described in this article , builds on the ISAAC findings by collecting further information on asthma , rhinitis and eczema prevalence , severity , diagnoses , asthma emergency room visits , hospital admissions , management and use of asthma essential medicines .  The subjects will be the same age groups as ISAAC , and their parents . In this first global monitoring of asthma in children and adults since 2003 , further evidence will be obtained to underst and asthma , management practice s and risk factors , leading to further recognition that asthma is an important non-communicable disease and to reduce its global burden . The Global Asthma Network undertakes global studies of asthma surveillance , management and risk factors Flaws in the design , conduct , analysis , and reporting of r and omised trials can cause the effect of an intervention to be underestimated or overestimated . The Cochrane Collaboration ’s tool for assessing risk of bias aims to make the process clearer and more UNLABELLED Mouth breathing can cause structural and functional alterations to the stomatognathic system . AIM The aim of this investigation was to study breathing , chewing , swallowing and speaking alterations present in patients with allergic rhinitis and associate it to rhinitis symptom intensity . MATERIAL S AND METHODS 170 patients between the ages of 6 and 55 years were prospect ively evaluated in this study , all of them underwent both otorhinolaryngological and speech evaluation .  Data on breathing , chewing , swallowing and speaking was gathered , as well as data from the medical evaluation . The data was compared and statistically analyzed . RESULTS The difference in signs and symptoms ' score between GR and GC was significant . We noticed a significant difference between GR and GC in breathing , chewing and swallowing . We observed a significant association between the score of nasal obstruction and the intensity of breathing and chewing alterations . CONCLUSION Patients with allergic rhinitis have functional alterations in their stomatognathic system and an increase in nasal obstruction scores can be considered as a indication of such alterations Abstract The objectives of the current study were to analyze the effects of orofacial myofunctional therapy ( OMT ) on the treatment of subjects with associated articular and muscular temporom and ibular disorders ( TMD ) . Thirty subjects with associated articular and muscular TMD , according to the Research Diagnostic Criteria ( RDC/TMD ) , were r and omly divided into groups : 10 were treated with OMT ( T group ) , 10 with an occlusal splint ( OS group ) , and 10 untreated control group with TMD ( SC ) . Ten subjects without TMD represented the asymptomatic group ( AC ) . All subjects had a clinical examination and were interviewed to determine Helkimo ’s Indexes ( Di and Ai ) , the frequency and severity of signs and symptoms , and orofacial myofunctional evaluation . During the diagnostic phase , there were significant differences between groups T and AC . There were no significant differences between group T and OC and SC groups . During the final phase , groups T and OS presented significant improvement , however , the group T presented better results and differed significantly from group OS regarding the number of subjects classified as AiII ; the severity of muscular pain and TMJ pain ; the frequency of headache and the muscles and stomatognathic functions . The group T differed significantly from the SC group but no longer differed significantly from the AC group . OMT favored a significant reduction of pain sensitivity to palpation of all muscles studied but not for the TMJs ; an increased measure of m and ibular range of motion ; reduced Helkimo ’s Di and Ai scores ; reduced frequency and severity of signs and symptoms ; and increased scores for orofacial myofunctional conditions OBJECTIVE To determine the impact of speech therapy on asthma and allergic rhinitis control in mouth breathing children and adolescents . METHODS This was a quasi-experimental r and omized study of 24 mouth breathing patients with asthma and allergic rhinitis , aged from 6 to 15 years . All patients were taking beclomethasone diproprionate through oral inhalation at the start of the study . At enrollment on the study , oral inhalation was substituted with exclusively nasal inhalation and 1 month later half of the patients began speech therapy . They attended 16 speech therapy sessions in 8 weeks and continued taking beclomethasone dipropionate through exclusively nasal inhalation ( BDT group ) . The comparison group received only beclomethasone diproprionate through exclusively nasal inhalation ( BDI group ) . Both groups were assessed five times . Clinical scores were calculated for allergic rhinitis and asthma , an adapted version of the Marchesan orofacial myofunctional assessment protocol was applied , and parents/guardians ' observations were recorded , in addition to spirometry measurements of peak inspiratory and peak expiratory flow . RESULTS There were significant improvements in the BDT group : clinical asthma score at T5 ( p = 0.046 ) ; peak inspiratory flow at T4 ( p = 0.030 ) ; peak expiratory flow at T3 ( p = 0.008 ) ; breathing mode and lip position ( p = 0.000 ) from T3 onwards ; and parents/guardians ' observations at T2 , T4 , and T5 ( p = 0.010 ; p = 0.027 ; p = 0.030 ) . CONCLUSIONS Speech therapy in combination with beclomethasone diproprionate through exclusively nasal inhalation result ed in earlier and longer-lasting clinical and functional control of asthma , allergic rhinitis , and mouth breathing than was achieved in the group that only took beclomethasone diproprionate 
    Output:
    
There is no scientific evidence on the efficacy of orofacial myofunctional therapy in improving clinical control , orofacial function , and nasal breathing in patients with asthma and rhinitis