***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: PURPOSE To examine the longitudinal association between age and intraocular pressure ( IOP ) in a large sample of Korean men and women . METHODS We conducted a prospect i ve cohort study of 274,064 young and middle-aged Korean adults with normal fundoscopic findings , following them from January 1 , 2002 , to February 28 , 2010 . Health exams were scheduled annually or biennially . At each visit ,  IOP was measured in both eyes using automated noncontact tonometers . The longitudinal change in IOP with age was evaluated using three-level mixed models for longitudinal paired-eye data , accounting for correlations between paired eyes and repeated measurements over time . RESULTS In fully adjusted models , the average longitudinal change in IOP per 1-year increase in age was -0.065 mm Hg ( 95 % confidence interval [ CI ] -0.068 to -0.063 ) , with marked sex differences ( P < 0.001 ) . In men , the average annual IOP change was -0.093 mm Hg ( 95 % CI -0.096 to -0.091 ) throughout follow-up . In women , the average annual IOP change was -0.006 mm Hg ( 95 % CI -0.010 to -0.003 ) , with a relatively flat association in the age range of 30 to 59 years and more marked annual decreases at younger and older ages . CONCLUSIONS Intraocular pressure was inversely associated with age in a large cohort of Korean adults attending health-screening visits . For men , this inverse association was observed throughout the entire age range , while for women it was evident only in younger ( < 30 years of age ) and older ( ≥60 years of age ) women , with no association in women aged 30 to 59 . Further research is needed to better underst and the underlying mechanisms and to reconsider cutoffs for defining high IOP by age and sex groups in Asian population OBJECTIVE To vali date an FFQ for the assessment of dietary EPA and  DHA  against their relative concentrations in red blood cells ( RBC ) . DESIGN Cross-sectional analysis of baseline data . Intakes of marine food products and EPA and DHA were estimated by FFQ on the basis of consumption of marine food products in the last month . Fatty acid composition of RBC membranes was quantified by GC . SETTING Saint-François d'Assise Hospital , Québec , Canada . SUBJECTS A total of sixty-five middle-aged women who participated in a r and omized clinical trial . RESULTS Spearman 's correlation coefficient between intake of EPA , DHA and EPA + DHA  and their corresponding concentration in RBC was 0.46 , 0.40 and 0.42 , respectively ( all P < 0.05 ) . Multiple regression analysis of EPA+DHA intake and RBC EPA + DHA concentration indicated positive and significant correlations for oily fish ( beta = 0.44 , 95 % CI 0.16 , 0.72 , P = 0.0027 ) , total fish ( beta = 0.42 , 95 % CI 0.19 , 0.64 , P = 0.0005 ) and marine food products ( beta = 0.42 , 95 % CI 0.20 , 0.64 , P = 0.0003 ) . No other marine food products significantly predicted RBC EPA + DHA concentration . CONCLUSIONS Although the present validation study was undertaken among middle-aged women with low consumption of marine food products ( <3 servings/week ) , our FFQ provided estimates of EPA and DHA intakes that correlated fairly well with their RBC concentrations . However , the absence of correlations between EPA + DHA intakes from different marine species suggests that a minimum EPA  + DHA intake is necessary to observe a relationship with RBC EPA + DHA concentrations OBJECTIVE To determine whether heart function in childhood is affected by exposure to methylmercury ( MeHg ) from seafood . STUDY DESIGN Prospect i ve study of a Faroese birth cohort ( N=1022 ) . Examinations at ages 7 and 14 years included blood pressure , heart rate variability ( HRV ) and its frequency components of autonomic origin , and brainstem auditory evoked potentials ( BAEPs ) . Mercury concentrations were determined in cord blood and in the child 's hair . RESULTS Both low-frequency ( LF ) and high-frequency ( HF ) activities decreased by about 25 % from 7 to 14 years ; they correlated well with the blood pressures . A doubling of prenatal MeHg exposure was associated with a decrease in LF and HF powers of about 6.7 % ( P=.04 ) and in the coefficient of variation of the electrocardiographic R-R interval of 2.7 % ( P=.04 ) at age 14 years . No discernible effect on blood pressure was apparent . Decreased LF variability was associated with increased latency of BAEP peak III , but adjustment for MeHg exposure substantially attenuated this correlation . CONCLUSIONS Methylmercury exposure was associated with decreased sympathetic ( LF ) and parasympathetic ( HF ) modulation of the HRV . Parallel MeHg-related delays of BAEP latencies may be caused by underlying MeHg neurotoxicity to brainstem nuclei 
    Output:
    
The association of prenatal mercury exposure with lower high-frequency b and scores ( thought to reflect parasympathetic activity ) in several studies , in particular the inverse association of cord blood mercury levels with the coefficient of variation of the R-R intervals and with low-frequency and high-frequency b and s at 14 years of age in the Faroe Isl and s birth cohort study , suggests that early mercury exposure could have a long-lasting effect on cardiac parasympathetic activity .