***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Purpose sThe inflammatory response after surgery is associated with various postoperative complications . The aim of the present prospect i ve study was to evaluate the effects of Daikenchuto ( DKT ) ( a Japanese herbal medicine ) on the inflammatory response in patients following laparoscopic colorectal resection . Methods Thirty patients who underwent laparoscopic colectomy for colorectal carcinoma were divided into two groups : a DKT intake group ( D group , n = 15 ) and a control group ( C group , n = 15 ) . The D group took 7.5 g/day of DKT from the day after surgery until the 7th postoperative day . The body temperature , heart rate , WBC count , lymphocyte count , C-reactive protein ( CRP ) level , β-d-glucan level and C and ida index were compared between the two groups . Results The patients ’ mean age in the D group was significantly younger than that in the C group . D3 lymph node dissection was performed more often in the D group . The time until first flatus was significantly shorter in the D group ( 1.8 ± 0.5 days ) than in the C group ( 2.7 ± 0.5 days ) . The CRP level was significantly lower in the D group ( 4.6 ± 0.6 mg/dl ) than in the C group ( 8.3 ± 1.1 mg/dl ) on the 3rd postoperative day . Conclusions Postoperative DKT administration significantly suppressed the CRP level and shortened the time until first flatus . DKT administration also significantly suppressed postoperative inflammation following surgery for colorectal cancer Background Daikenchuto ( TJ-100 ) , a traditional Japanese herbal medicine , is widely used in Japan . Its effects on gastrointestinal motility and microcirculation and its anti-inflammatory effect are known . The purpose of this prospect i ve r and omized controlled trial was to investigate the effect of TJ-100 after esophagectomy in esophageal cancer patients . Methods Forty patients for whom subtotal esophageal resection for esophageal cancer was planned at our institute from March 2011 to August 2013 were enrolled and divided into two groups at the point of determination of the operation schedule after informed consent was obtained : a TJ-100 ( 15 g/day)-treated group ( n = 20 ) and a control group ( n = 20 ) . The primary efficacy end-points were maintenance of the nutrition condition and the recovery of gastrointestinal function . The secondary efficacy end-points were the serum C-reactive protein ( CRP ) level and adrenomedullin level during the postoperative course , the incidence of postoperative complications , and the length of hospital stay after surgery . Results We examined 39 patients because one patient in the TJ-100 group was judged as having unresectable cancer after surgery . The mean age of the TJ-100 group patients was significantly older than that of the control group patients .The  rate of body weight decrease at postoperative day 21 was significantly suppressed in the TJ-100 group ( 3.6 % vs. the control group : 7.0 % , p = 0.014 ) , but the serum albumin level was not significantly different between the groups . The recovery of gastrointestinal function regarding flatus , defecation , and oral intake showed no significant between-group differences , but postoperative bowel symptoms tended to be rare in the TJ-100 group . There was no significant between-group difference in the length of hospital stay after surgery . The serum CRP level at postoperative day 3 was 4.9 mg/dl in the TJ-100 group and 6.9 mg/dl in the control group , showing a tendency of a suppressed serum CRP level in the TJ-100 group ( p = 0.126 ) . The rate of increase in adrenomedullin tended to be high postoperatively , but there was no significant difference between the two groups . Conclusions TJ-100 treatment after esophageal cancer resection has the effects of prompting the recovery of gastrointestinal motility and minimizing body weight loss , and it might suppress the excess inflammatory reaction related to surgery Purpose This study aim ed to assess the efficacy of daikenchuto ( DKT ) , a commonly prescribed , traditional Japanese herbal medicine , on  postoperative intestinal dysfunction after gastric cancer surgery . Methods Patients with gastric cancer scheduled for a total gastrectomy were r and omly assigned before surgery to receive either no treatment ( n = 40 ; control group ) or DKT ( 7.5 g/day , t.i.d . ) for 3 months ( n = 41 ) postoperatively . We examined gastrointestinal motility , stool attributes , the quantity of bowel gas , the quality of life , and the incidence of postoperative ileus . Results During the hospital stay , significant differences were observed between the DKT group and controls in the number of stools per day ( 1.1 ± 0.6 vs 0.8 ± 0.4 , respectively ; P = 0.037 ) and stool consistencies ( Bristol scale ratings were 3.7 ± 0.8 vs 3.1 ± 0.8 , respectively ; P = 0.041 ) . The DKT group showed significant reductions in gas volume scores , calculated from abdominal radiographs , at 7 days , 1 month , and 3 months after surgery . The groups did not show significant differences in quality of life scores ( based on the Gastrointestinal Symptom Rating Scale ) or in the incidence of postoperative ileus . Conclusion DKT  improved bowel movements , stool properties , and bowel gas . These results suggested that DKT promoted early postoperative bowel functions after total gastrectomy Background This exploratory trial was conducted to investigate whether daikenchuto accelerates the recovery of gastrointestinal function in patients undergoing open surgery for sigmoid or rectosigmoid cancer . Methods Eighty-eight patients who underwent colectomy at one of the 11 clinical trial sites in Japan from January 2009 to June 2011 were registered in the study . Patients received either placebo or daikenchuto ( 15.0 g/day , 5 g three times a day ) from postoperative day 2 to postoperative day 8 . The study end points included the gastrointestinal tract transit time evaluated with radiopaque markers and the time to first flatus . The safety profile of daikenchuto was also evaluated until postoperative day 8 . Results Seventy-one patients  ( daikenchuto , n = 38 ; placebo , n = 33 ) were statistically analyzed . Although the number of radiopaque markers in the anal side of the small intestine at 6 h was significantly greater in the daikenchuto group than in the placebo group ( 15.19 vs 10.06 , p = 0.008 ) , the total transit analysis results and the mean time to first flatus did not differ significantly between the two groups . Conclusions Daikenchuto has a positive effect on the resolution of delayed gastric emptying , but has a limited effect on the resolution of postoperative paralytic ileus after open surgery in patients with sigmoid or rectosigmoid cancer .  Daikenchuto may contribute to early oral intake in the postoperative course BACKGROUND / AIMS Paralytic ileus after laparoscopic-assisted surgery often occurs . We investigated whether daikenchuto ( DKT ) , a traditional Japanese herbal medicine , improves intestinal motility in patients undergoing laparoscopic-assisted colectomy for colon cancer . METHODOLOGY Fifty-four patients who underwent colectomy at Iwate Medical University Hospital between October 2010 and March 2012 were r and omized to either the DKT group ( 7.5 g/day , p.o . ) or the control group ( lactobacillus preparation , 3g/day , p.o . ) . Primary endpoints included time to first flatus , bowel movement , and tolerance of diet after extubation . Secondary endpoints were WBC count , C-reactive protein ( CRP ) level , length of hospital stay , and postoperative ileus . Colonic transit time was measured using radiopaque markers and abdominal radiographs . RESULTS Fifty-one patients ( DKT , 26 vs. control , 25 ) were included in the per- protocol analysis . The DKT group had significantly faster time until first flatus ( 67.5 + /- 13.6h vs. 77.9 + /- 11.8h , P < 0.01 ) and bowel movement ( 82.9 + /- 17.8h vs. 99.5 + /- 18.9h , P < 0.01 ) and colonic transit time ( 91.9 + /- 19.8h vs. 115.2 + /- 12.8 h , P < 0.05 ) . There were no significant intergroup differences in secondary endpoints and adverse events . CONCLUSIONS DKT accelerates colonic motility in patients undergoing laparoscopic-assisted colectomy for colon cancer BACKGROUND Daikenchuto ( DKT ) has widely been used to improve abdominal symptoms by being expected to accelerate bowel motility . The purpose of this study is to examine the efficacy and safety of DKT for prevention of ileus and associated gastrointestinal symptoms after total gastrectomy . STUDY DESIGN Two hundred and forty-five gastric cancer patients who underwent total gastrectomy were enrolled . Patients received either DKT ( 15.0 g/d ) or matching placebo from postoperative days 1 to 12 . Primary end points were time to first flatus , time to first bowel movement ( BM ) , and frequency of BM . Secondary end points included quality of life , C-reactive protein level , symptoms indicative of a severe gastrointestinal disorder , and incidence of postoperative ileus . RESULTS A total of 195 patients ( DKT , n = 96 ; placebo , n = 99 ) were included in the per- protocol set analysis . There were no significant differences between the groups in terms of patient background characteristics . Median time to first BM was shorter in the DKT group than in the placebo group ( 94.7 hours vs 113.9 hours ; p = 0.051 ) . In patients with high medication adherence , median time to first BM was significantly shorter in the DKT group than in the placebo group ( 93.8 hours vs 115.1 hours ; p = 0.014 ) . Significantly fewer patients in the DKT group had ≥2 symptoms of gastrointestinal dysfunction than those in the placebo group on postoperative day 12 ( p = 0.026 ) . CONCLUSIONS Administration of DKT during the immediate postoperative period after total gastrectomy appears to promote early recovery of postoperative bowel function 
    Output:
    
As a result of meta- analysis by all retrieved according to the registered protocol , daikenchuto was efficacious in improving postoperative bowel dysfunction  in patients with gastrointestinal cancers .