***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: The CLU gene is one of the prime genetic c and i date s associated with Alzheimers disease . In the present study CLU genotypes and haplotypes were associated with baseline cognition and the rate of cognitive decline in two cohorts , the Danish 1905 birth cohort ( 93 years of age in 1998 ) and the Longitudinal Study of Aging Danish twins ( LSADT ) ( 73–83 year old twins in 1997 ) .  Both Mini Mental State Examination ( MMSE ) and a cognitive composite score was attained up to six times for up to 10 years and analysed using r and om effects models and vital status . The rs11136000 T allele was associated with better baseline cognitive performance both in the LSADT ( effect on intercept : 0.41 95 % CI [ −0.04 ; 0.87 ] ) and the 1905 birth cohort ( effect on intercept : 0.28 95 % CI [ 0.01 ; 0.55 ] ) , although it did not reach significance in the LSADT cohort . However , the rs11136000 T allele was significantly associated with a steeper decline ( effect on slope : −0.06 95 % CI [ −0.11 ; −0.01 ] ) in the LSADT cohort , but not in the 1905 birth cohort . Haplotype analyses revealed that carriers of the common rs11136000 , rs1532278 and rs9331888 TTC haplotype ( 36 % ) in the CLU gene performed cognitively better than non-carriers in the 1905 birth cohort ( effect on intercept : 0.50 95 % CI [ 0.12 ; 0.91 ] ) and carriers of a rare TCC haplotype ( 1 % ) performed worse on the cognitive composite score ( effect on intercept : −1.51 95 % CI [ −2.92 ; −0.06 ] ) . The association between the TTC haplotype and better cognitive composite score was higher among those surviving past the age of 98 ( p = 0.014 ) , and among these the TTC haplotype was borderline associated with a steep decline ( effect on slope : −0.13 95 % CI [ −0.27 ; 0.00 ] ) . In summery CLU genetic variants associate with cognition in two cohorts , but the genetic effect of CLU seems to regress toward the mean when aging 
    Output:
    
Our meta- analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD ; the APOE ε4 status did not influence the relationship .