***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: The range of neuropsychiatric symptoms in multiple sclerosis ( MS ) has not been prospect ively assessed . The authors , working at a tertiary medical center in Mexico City , used the Neuropsychiatric Inventory ( NPI ) to evaluate neuropsychiatric symptoms prospect ively in 44 MS patients who were stable between relapses and 25 control subjects of similar age , education , and cognitive function .  Neuropsychiatric symptoms were present in 95 % of patients and 16 % of control subjects . Changes present were depressive symptoms ( 79 % ) , agitation ( 40 % ) , anxiety ( 37 % ) , irritability ( 35 % ) , apathy ( 20 % ) , euphoria ( 13 % ) , disinhibition ( 13 % ) , hallucinations ( 10 % ) , aberrant motor behavior ( 9 % ) , and delusions ( 7 % ) . The only relationships with MRI were between euphoria and hallucinations and moderately severe MRI abnormalities . The authors conclude that diverse types of neuropsychiatric symptoms are common in MS ; symptoms are present between exacerbations ; and there are variable correlations with MRI abnormalities Reliability and construct validity are reported for the Frontal Lobe Personality Scale ( FLOPS ) , a brief neurobehavior rating scale . The FLOPS Family form was completed by family members of 24 frontal lobe brain-damaged patients , 15 non-frontal lobe braindamaged patients , and 48 healthy controls . Intrascale reliability was demonstrated ( internal consistency .96 ; split half .93 ) . Validity studies of frontal lobe patients post-lesion compared to their pre-lesion status , to healthy controls , and of frontal lobe patients pre and post-lesion compared to non-frontal lobe patients pre and post-lesion , indicated that frontal lobe patients post-lesion showed significantly more " frontal " behavior than ( a ) pre-lesion frontal lobe patients , ( b ) healthy controls , and ( c ) post-lesion non-frontal lobe patients . The FLOPS appears to be useful for quantifying frontal lobe behavior in clinical and research setting Objective The current study examines the utility of the Frontal Systems Behavior Scale  ( FrSBe ) to document behavioral changes in people with multiple sclerosis ( MS ) . Background MS results in widespread central nervous system lesions that have a propensity for affecting frontal and parietal brain regions . As a result , behavioral symptoms may present , including disorders of executive functioning , apathy , and disinhibition . Method Twenty-six people with MS and 15 healthy controls ( HC ) underwent neuropsychological testing and completed the Frontal Systems Behavior Scale ( FrSBe ) , and measures of emotional functioning . Results Behavioral ratings for the MS group prior to illness were equivalent to those of the HC group . After illness however , a clinical ly and statistically significant increase was noted on two of three FrSBe scales , the apathy scale and the executive dysfunction scale . Relationships were also noted between the FrSBe family and self-report forms after illness and measures of neuropsychological performance , particularly information processing , working memory , and executive control . In contrast , physical disease progression was correlated with family ratings of behavior , but not self-ratings . Conclusions The FrSBe appears to be a sensitive measure of behavioral change in people with MS . Self-ratings and family ratings of behavioral changes are related to measures of neuropsychological performance . However , physical symptoms of MS are related only to the family ratings of behavior Although numerous studies have shown that brain-damaged patients tend to underestimate neuropsychological ( NP ) impairment when self-ratings are compared to informant ratings , the meaning of such discrepancies is not well studied in multiple sclerosis ( MS ) . We compared patient self- and informant-report question naire ratings of NP functioning in 122 MS patients and 37 age- and education-matched normal controls . In addition to completing the Multiple Sclerosis Neuropsychological Question naire ( MSNQ ) , participants underwent NP testing and assessment of depression , personality , and neuropsychiatric symptoms . Based on the normal distribution of discrepancy scores , patients were classified according to whether they overestimated or underestimated their cognitive ability , relative to informant ratings . ANOVAs comparing test scores derived from overestimators , underestimators , and accurate estimators were significant for multiple measures of cognitive function , depression , personality , and neuropsychiatric symptoms . Overestimators were characterized by less depression and conscientiousness , and greater degrees of cognitive impairment , euphoric behavioral disinhibition , and unemployment as compared to underestimators . We conclude that patient/informant discrepancy scores on the MSNQ are associated with the aforementioned neuropsychiatric features , and that the MSNQ has potential utility for predicting euphoria and disinhibition syndromes in MS 
    Output:
    
Based on the literature search , behavioural symptoms and impairments are observed in MS .
Severe mental disorders are more infrequent than changes in behaviour , manner of reaction , and way of action .
In conclusion the objective behavioural impairments and especially subjective symptoms are present in patients with MS .