***TASK*** the task is to summarize an input biomedical literature in six sentences 
    ***INPUT*** the input is a biomedical literature 
    ***OUTPUT*** the output is the summary of an input biomedical literature in six sentences 
    ***DOCUMENTATION*** 
    ***EXAMPLES*** 
    Input: Sixty consecutive collegiate athletes with “ high ” ankle symptoms were prospect ively evaluated over a 3-year period in an effort to better define this debilitating ankle injury . All athletes included in this study had tenderness over the distal anterior tibiofibular ligament , tenderness proximally along the interosseous membrane , and functional disability . No study subject had a fracture or frank tibia-fibula diastasis . The severity of the sprain was quantified using the interosseous “ tenderness length . ” A st and ard rehabilitation protocol was followed by all patients . Athletes returned to competition when they could perform all functional testing without difficulty . Time to return to full competitive activity averaged 13.4 days . The number of days missed from competition was statistically related to the interosseous tenderness length ( P 0.0001 ) and to positive results on the squeeze test ( P 0.03 ) . Fifty-three of the 60 injured athletes were evaluated at least 6 months after injury . Patients rated their outcomes as good or excellent . Six of the patients experienced occasional ankle pain and stiffness , four patients reported recurrent ankle sprains , and one patient had heterotopic ossification formation Seventy-two patients with subacute or chronic rupture of the anterior cruciate ligament were r and omly assigned to autograft reconstruction with four-str and gracilis and semitendinosus tendon ( N = 37 ) or with patellar tendon-bone ( N = 35 ) from the ipsilateral side . The groups were similar in terms of age , sex , level of activity , degree of laxity , meniscal lesions found surgically , and rehabilitation program . The follow-up was performed at another hospital by independent observers after 6 , 12 , and 24 months . Sixty-one patients ( 32 with hamstring tendon grafts and 29 with patellar tendon grafts ) complied with the follow-up routine for the full 24 months . No differences were found between the groups with respect to Cincinnati functional score , KT-1000 arthrometer measurements , or stairs hopple test results . The subjective result and the single-legged hop test result were better for the hamstring tendon group after 6 and 12 months , but no differences were found after 24 months . The hamstring tendon group showed better isokinetic knee extension strength than did the patellar tendon group after 6 months , but not after 12 and 24 months . There was a significant weakness in isokinetic knee flexion strength among the hamstring tendon group . Anterior knee pain was not significantly different between the groups , but kneeling pain was significantly less common in the hamstring tendon group after 24 months In a two-centre study , 164 patients with unilateral instability of the anterior cruciate ligament were prospect ively r and omised to arthroscopic reconstruction with either a patellar tendon graft using interference screw fixation or a quadruple semitendinosus graft using an endobutton fixation technique . The same postoperative rehabilitation protocol was used for all patients and follow-up at a median of 31 months ( 24 to 59 ) was carried out by independent observers . Four patients ( 2 % ) were lost to follow-up . No significant differences were found between the groups regarding the Stryker laxity test , one-leg hop test , Tegner activity level , Lysholm score , patellofemoral pain score , International Knee Documentation Committee ( IKDC ) score or visual analogue scale , reflecting patient satisfaction and knee function . Slightly decreased extension , compared with the non-operated side , was found in the patellar tendon group ( p < 0.05 ) . Patients with associated meniscal injuries had lower IKDC , visual analogue ( p < 0.01 ) and Lysholm scores ( p < 0.05 ) than those without such injuries . Patients in whom reconstruction had been carried out less than five months after the injury had better final IKDC scores than the more chronic cases ( p < 0.05 ) . We conclude that patellar tendon and quadruple semitendinous tendon grafts have similar outcomes in the medium term . Associated meniscal pathology significantly affects the final outcome and early reconstruction seems to be beneficial The purpose of this study was to examine a young athletic population to up date the data regarding epidemiology and disability associated with ankle injuries . At the United States Military Academy , all cadets presenting with ankle injuries during a 2-month period were included in this prospect i ve observational study . The initial evaluation included an extensive question naire , physical examination , and radiographs . Ankle sprain treatment included a supervised rehabilitation program . Subjects were reevaluated at 6 weeks and 6 months with subjective  assessment , physical  examination  , and functional testing . The mean age for all subjects was 20 years ( range , 17–24 years ) . There were 104 ankle injuries accounting for 23 % of all injuries seen . There were 96 sprains , 7 fractures , and 1 contusion . Of the 96 sprains , 4 were predominately medial injuries , 76 were lateral , and 16 were syndesmosis sprains . Ninety-five percent had returned to sports activities by 6 weeks ; however , 55 % of these subjects reported loss of function or presence of intermittent pain , and 23 % had a decrement of > 20 % in the lateral hop test when compared with the uninjured side . At 6 months , all subjects had returned to full activity ; however , 40 % reported residual symptoms and 2.5 % had a decrement of > 20 % on the lateral hop test . Neither previous injury nor ligament laxity was predictive of chronic symptomatology . Furthermore , chronic dysfunction could not be predicted by the grade of sprain ( grade I vs. II ) . The factor most predictive of residual symptoms was a syndesmosis sprain , regardless of grade . Syndesmosis sprains were most prevalent in collision sports . This study demonstrates that even though our knowledge and underst and ing of ankle sprains and rehabilitation of these injuries have progressed in the last 20 years , chronic ankle dysfunction continues to be a prevalent problem . The early return to sports occurs after almost every ankle sprain ; however , dysfunction persists in 40 % of patients for as long as 6 months after injury . Syndesmosis sprains are more common than previously thought , and this confirms that syndesmosis sprains are associated with prolonged disability Abstract A total of 41 consecutive patients ( 11 women and 30 men , median age 29 ( 18–51 ) years ) with unilateral , isolated , posttraumatic , recurrent anterior shoulder dislocation and a Bankart lesion were operatively repaired , either by an arthroscopic technique including a capsular plication , or by an open procedure with Mitec anchors . All the patients were followed prospect ively and evaluated after a median of 36 ( 30–52 ) months follow-up by a “ blind ” observer . Nineteen patients in each group had excellent or good results , and one in each group was grade d as fair . One patient in the arthroscopic group had a traumatic dislocation 5 months after the operation and was grade d as poor . Three patients experienced subluxations postoperatively , one in the arthroscopic and two in the open group . There was no significant difference in anterior-posterior shoulder laxity measured objective ly with Donjoy . The open Bankart repair group had a statistically significantly longer hospitalization ( P = 0.001 ) , a slight decrease in external range of motion , and more frequent cosmetic complaints . Apart from this , the results revealed no major differences between the two methods after a median of 36 months in this selected group of patients with longst and ing problems PURPOSE The purpose of this study was to compare the results of arthroscopic and open repair of isolated Bankart lesions of the shoulder using metallic suture anchors . TYPE OF STUDY Prospect i ve r and omized clinical study . METHODS Sixty patients with traumatic anterior shoulder instability underwent a surgical repair of an isolated Bankart lesion . The patients were divided into 2 groups of 30 patients each . In group 1 , an arthroscopic repair was performed , and in group 2 , an open procedure was performed . The groups were homogeneous for gender , age , dominance , number of dislocations , time elapsed between first dislocation and surgery , and pathologic findings . In all cases of both groups , the lesion was repaired using metallic suture anchors carrying nonabsorbable braided sutures . Postoperative rehabilitation was the same for the 2 groups . Two years ' follow-up evaluation included Constant and Rowe shoulder scores . Statistical analysis of data was performed using an unpaired t test ( significance for P < .05 ) . RESULTS No recurrence of dislocation of the involved shoulder has been reported in either group . Follow-up Constant and Rowe scores of the 2 groups were not significantly different . The only significant difference seen between the 2 groups was for range of motion evaluation with the Constant score . The mean value for group 1 ( 39.6 + /- 0.8 ) was significantly greater ( P = .017 ) than that for group 2 ( 37.8 + /- 2.0 ) . CONCLUSIONS Arthroscopic repair with suture anchors is an effective surgical technique for the treatment of an isolated Bankart lesion . Open repair does not offer a significantly better 2-year result in terms of stability , and furthermore , can negatively affect the recovery of full range of motion of the shoulder . LEVEL OF EVIDENCE Level BACKGROUND The aim of the study was to compare the results after arthroscopic anterior cruciate ligament ( ACL ) reconstruction  using central -third bone-patellar tendon-bone ( BTB ) autografts and triple/quadruple semitendinosus ( ST ) autografts . HYPOTHESIS In the long-term , ACL reconstruction using BTB autografts will render more donor-site problems than ST autografts . STUDY DESIGN R and omized controlled trial ; Level of evidence , 1 . METHODS A r and omized series of 71 patients ( 22 women and 49 men ) with a unilateral ACL rupture who underwent reconstructive surgery were included in the study . The BTB graft was used in 34 patients ( BTB group ) and the ST-tendon graft was used in 37 patients ( ST group ) . The patients were examined a median of 86 months ( range , 68 to 114 months ) after the reconstruction . RESULTS Sixty-eight of 71 patients ( 96 % ) were examined at follow-up . The clinical assessment s at follow-up revealed no significant differences between the BTB group and the ST group in terms of the Lysholm score , Tegner activity level , International Knee Documentation Committee evaluation system , 1-legged hop test , KT-1000 arthrometer laxity measurements , manual Lachman test , and range of motion . A significant improvement was seen in both groups compared with the preoperative values in terms of most clinical assessment s. Donor-site morbidity in the form of knee-walking ability , kneeling ability , and area of disturbed anterior knee sensitivity revealed no significant differences between the groups . CONCLUSION Seven years after ACL reconstruction , the subjective and objective outcomes were similar after using the central -third BTB autograft and triple/quadruple ST autograft . Furthermore , no difference in terms of donor-site morbidity was found between the 2 groups PURPOSE The aim of this study was to compare the results after arthroscopic anterior cruciate ligament ( ACL ) reconstruction using central -third , bone-patellar tendon-bone ( BPTB group ) , 3-str and semitendinosus ( ST group ) , or 4-str and semitendinosus/gracilis ( ST/G group ) autografts . TYPE OF STUDY Prospect i ve r and omized trial . METHODS A r and omized series of 134 patients , all with unilateral ACL rupture was included in the study . In all 3 groups , interference screw fixation of the graft was used at both ends and 125 of 134 ( 93 % ) of the patients returned for the follow-up examination after 26 months ( range , 20 to 43 months ) . The preoperative assessment s in all 3 groups were similar in terms of gender , Tegner activity level , Lysholm score , KT-1000 measurements , 1-leg hop test , and the knee-walking test . RESULTS At follow-up , the knee-walking test was significantly worse in the BPTB group than in the ST group ( P = .0004 ) and ST/G group ( P < .0001 ) . Furthermore , the knee-walking test was significantly worse at follow-up than preoperatively in the BPTB group ( P < .0001 ) . The corresponding findings were not made in the other 2 groups . A significant reduction in knee laxity and an increase in activity level compared with the preoperative assessment s were found in all 3 groups , without any significant differences between the groups . CONCLUSIONS Two years after ACL reconstruction , the use of ST and ST/G autografts rendered significantly less discomfort during the knee-walking test than the use of BPTB autografts . However , in terms of functional outcome and knee laxity , the groups displayed no significant differences . LEVEL OF EVIDENCE Level Seventy patients with patellar tendon or hamstring tendon autografts for single-incision anterior cruciate ligament reconstruction were evaluated at least 2 years after surgery . All reconstructions were performed by the same surgeon , and metal interference screws were used for fixation of all grafts . No significant differences were noted between groups for Lysholm score , reduction in activity , KT-1000 arthrometer findings , quadriceps muscle 
    Output:
    
In the hierarchy of medical evidence , systematic review s including meta-analyses represent the highest form of evidence if inclusion is limited to Level-I or II studies ( Table I ) .