human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The mouse polyomavirus encodes a tumor-suppressor gene inactivator in its large T protein and a proto-oncogene activator in its middle T protein . We have used site-directed mutagenesis to selectively inactivate the former function without affecting the latter . Two mutant viruses were constructed to encode altered large T proteins that fail to bind the retinoblastoma tumor-suppressor gene product pRB , along with normal small and middle T proteins . The pRB-binding mutants proved to be defective in immortalization of primary rat embryo fibroblasts by a variety of tests . Yet they proved capable of transforming both primary and established fibroblasts in culture . Most importantly , the inability of these mutants to bind pRB had little effect on their ability to induce tumors in mice . We conclude that induction of multiple tumor types in this system does not depend on large T-pRB interactions but rather on middle T-dependent pathways . In addition , the ability of this virus to immortalize cells in culture is not essential to its ability to induce tumors in the animal .
    OUTPUT:

agent
enabling replicative immortality
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The mouse polyomavirus encodes a tumor-suppressor gene inactivator in its large T protein and a proto-oncogene activator in its middle T protein . We have used site-directed mutagenesis to selectively inactivate the former function without affecting the latter . Two mutant viruses were constructed to encode altered large T proteins that fail to bind the retinoblastoma tumor-suppressor gene product pRB , along with normal small and middle T proteins . The pRB-binding mutants proved to be defective in immortalization of primary rat embryo fibroblasts by a variety of tests . Yet they proved capable of transforming both primary and established fibroblasts in culture . Most importantly , the inability of these mutants to bind pRB had little effect on their ability to induce tumors in mice . We conclude that induction of multiple tumor types in this system does not depend on large T-pRB interactions but rather on middle T-dependent pathways . In addition , the ability of this virus to immortalize cells in culture is not essential to its ability to induce tumors in the animal .
    OUTPUT:
