human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Melanoma cells express and interact with laminins ( LMs ) and other basement membrane components during invasion and metastasis . In the present study we have investigated the production and migration-promoting activity of laminin isoforms in melanoma . Immunohistochemistry of melanoma specimens and immunoprecipitation/western blotting of melanoma cell lines indicated expression of laminin-111/121 , laminin-211 , laminin-411/421 , and laminin-511/521 . Laminin-332 was not detected . In functional assays , laminin-111 , laminin-332 , and laminin-511 , but not laminin-211 and laminin-411 , strongly promoted haptotactic cell migration either constitutively or following stimulation with insulin-like growth factors . Both placenta and recombinant laminin-511 preparations were highly active , and the isolated recombinant IVa domain of LMÎ±5 also promoted cell migration . Function-blocking antibodies in cell migration assays revealed Î±6Î²1 integrin as the major receptor for laminin-111 , and both Î±3Î²1 and Î±6Î²1 integrins for laminin-332 and laminin-511 . In contrast , isolated LMÎ±5 IVa domain-promoted melanoma cell migration was largely mediated via Î±VÎ²3 integrin and inhibited by RGD peptides . Given the ubiquitous expression of Î±5 laminins in melanoma cells and in melanoma-target tissues/anatomical structures , as well as the strong migration-promoting activity of these laminin isoforms , the Î±5 laminins emerge as putative primary extracellular matrix mediators of melanoma invasion and metastasis via Î±3Î²1 and other integrin receptors .
    OUTPUT:

agent
sustaining proliferative signaling;activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Melanoma cells express and interact with laminins ( LMs ) and other basement membrane components during invasion and metastasis . In the present study we have investigated the production and migration-promoting activity of laminin isoforms in melanoma . Immunohistochemistry of melanoma specimens and immunoprecipitation/western blotting of melanoma cell lines indicated expression of laminin-111/121 , laminin-211 , laminin-411/421 , and laminin-511/521 . Laminin-332 was not detected . In functional assays , laminin-111 , laminin-332 , and laminin-511 , but not laminin-211 and laminin-411 , strongly promoted haptotactic cell migration either constitutively or following stimulation with insulin-like growth factors . Both placenta and recombinant laminin-511 preparations were highly active , and the isolated recombinant IVa domain of LMÎ±5 also promoted cell migration . Function-blocking antibodies in cell migration assays revealed Î±6Î²1 integrin as the major receptor for laminin-111 , and both Î±3Î²1 and Î±6Î²1 integrins for laminin-332 and laminin-511 . In contrast , isolated LMÎ±5 IVa domain-promoted melanoma cell migration was largely mediated via Î±VÎ²3 integrin and inhibited by RGD peptides . Given the ubiquitous expression of Î±5 laminins in melanoma cells and in melanoma-target tissues/anatomical structures , as well as the strong migration-promoting activity of these laminin isoforms , the Î±5 laminins emerge as putative primary extracellular matrix mediators of melanoma invasion and metastasis via Î±3Î²1 and other integrin receptors .
    OUTPUT:
