human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The NF-ÎºB is best known for its role in inflammation . Here we show that constitutive NF-ÎºB activity in cancer cells promotes the biosynthesis of redox scavenger glutathione ( GSH ) , which in turn confers resistance to oxidative stress . Inhibition of NF-ÎºB significantly decreases GSH in several lines of human leukemia and prostate cancer cells possessing high or moderate NF-ÎºB activities . Concomitantly , NF-ÎºB inhibition by pharmacological and molecular means sensitizes " NF-ÎºB positive " cancer cells to chemically-induced oxidative stress and death . We propose that inhibition of NF-ÎºB can reduce intracellular GSH in " NF-ÎºB-positive " cancers thereby improving the efficacy of oxidative stress-based anti-cancer therapy .
    OUTPUT:

agent
tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The NF-ÎºB is best known for its role in inflammation . Here we show that constitutive NF-ÎºB activity in cancer cells promotes the biosynthesis of redox scavenger glutathione ( GSH ) , which in turn confers resistance to oxidative stress . Inhibition of NF-ÎºB significantly decreases GSH in several lines of human leukemia and prostate cancer cells possessing high or moderate NF-ÎºB activities . Concomitantly , NF-ÎºB inhibition by pharmacological and molecular means sensitizes " NF-ÎºB positive " cancer cells to chemically-induced oxidative stress and death . We propose that inhibition of NF-ÎºB can reduce intracellular GSH in " NF-ÎºB-positive " cancers thereby improving the efficacy of oxidative stress-based anti-cancer therapy .
    OUTPUT:
