human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: A 33-year-old man presented with pain and palsy of the leg in 2008 for treatment of hepatocellular carcinoma with huge distant metastases . The patient's tumors had slowly enlarged despite several treatments . Oral administration of sorafenib at 800 mg/day with careful observation was commenced in 2009 . Laboratory investigations on day 7 showed massive tumor lysis . An abdominal CT showed multiple low density areas and tumor markers decreased , indicating extended tumor necrosis . In conclusion , clinicians should bear in mind not only the published adverse effects , but also massive tumor lysis , when treating patients with large tumor burden by sorafenib .
    OUTPUT:

agent
resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: A 33-year-old man presented with pain and palsy of the leg in 2008 for treatment of hepatocellular carcinoma with huge distant metastases . The patient's tumors had slowly enlarged despite several treatments . Oral administration of sorafenib at 800 mg/day with careful observation was commenced in 2009 . Laboratory investigations on day 7 showed massive tumor lysis . An abdominal CT showed multiple low density areas and tumor markers decreased , indicating extended tumor necrosis . In conclusion , clinicians should bear in mind not only the published adverse effects , but also massive tumor lysis , when treating patients with large tumor burden by sorafenib .
    OUTPUT:
