human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Application of adenovirus vectors ( Adv ) in metastatic cancer treatment is limited . We previously demonstrated that covalent conjugation of polyethleneglycol ( PEG ) to Adv enhances therapeutic effects and decreases toxic side-effects after systemic administration , but the level of immune response to PEGylated Adv ( PEG-Ad ) was not examined . Here , we examined the effect of PEGylation of Adv on the production of anti-Adv antibodies and antitumor response . We constructed a set of PEG-Ad using 5-kDa PEG , with modification rates of 30% , 45% and 90% . After systemic administration of Advs to rats , we examined the level of anti-Adv immunoglobulin ( Ig)G and IgM in serum . The levels of anti-Adv IgG and anti-Adv IgM in rats treated with unmodified Adv were higher than those in control group . Rats treated with PEG-Ad that had a 90% modification rate showed lower level of anti-Adv IgG and anti-Adv IgM than those treated with unmodified Adv , whereas rats treated with PEG-Ad that had a 30% or 45% modification rate showed a similar level of anti-Adv IgG and IgM to those treated with unmodified Adv. Systemic administration of PEG-Ad that had a 90% modification rate , and expressed tumor necrosis factor-alpha , significantly reduced the number of metastatic colonies in the lung compared to unmodified Adv , with negligible side effects . These results suggest that systemic administration of PEG-Ad with an appropriate PEG modification rate has the potential to reduce the production of antibodies against Adv and increase the therapeutic response against metastatic cancer .
    OUTPUT:

agent
activating invasion and metastasis;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Application of adenovirus vectors ( Adv ) in metastatic cancer treatment is limited . We previously demonstrated that covalent conjugation of polyethleneglycol ( PEG ) to Adv enhances therapeutic effects and decreases toxic side-effects after systemic administration , but the level of immune response to PEGylated Adv ( PEG-Ad ) was not examined . Here , we examined the effect of PEGylation of Adv on the production of anti-Adv antibodies and antitumor response . We constructed a set of PEG-Ad using 5-kDa PEG , with modification rates of 30% , 45% and 90% . After systemic administration of Advs to rats , we examined the level of anti-Adv immunoglobulin ( Ig)G and IgM in serum . The levels of anti-Adv IgG and anti-Adv IgM in rats treated with unmodified Adv were higher than those in control group . Rats treated with PEG-Ad that had a 90% modification rate showed lower level of anti-Adv IgG and anti-Adv IgM than those treated with unmodified Adv , whereas rats treated with PEG-Ad that had a 30% or 45% modification rate showed a similar level of anti-Adv IgG and IgM to those treated with unmodified Adv. Systemic administration of PEG-Ad that had a 90% modification rate , and expressed tumor necrosis factor-alpha , significantly reduced the number of metastatic colonies in the lung compared to unmodified Adv , with negligible side effects . These results suggest that systemic administration of PEG-Ad with an appropriate PEG modification rate has the potential to reduce the production of antibodies against Adv and increase the therapeutic response against metastatic cancer .
    OUTPUT:
