human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Endothelin plays important roles in various physiological functions including vascular constriction . Recent studies reported that the endothelin receptors ETA and ETB are highly expressed in lung and skin tumor tissues . In contrast , there are few reports on endothelin signalling in the proliferation of head and neck cancer . We found that both ETA and ETB endothelin receptors were overexpressed in tumor cells of tongue cancer samples by immunohistochemistry . ETA and ETB were expressed in cultured lingual and esophageal squamous cell carcinoma ( SCCs ) cell lines . When both cultured cell lines were treated with an ETA selective antagonist ( BQ123 ) or an ETB selective antagonist ( BQ788 ) , inhibition of cell growth was observed . Similar results were observed when SCCs were treated with specific siRNA for the suppression of ETA or ETB . Furthermore , inhibition of the mitogen-activated protein ( MAP ) kinase pathway by the treatments with ET receptor antagonists and siRNA was also observed . These results indicate that endothelin signalling may , in part , play important roles in cell growth in SCCs through the MAP kinase pathway .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Endothelin plays important roles in various physiological functions including vascular constriction . Recent studies reported that the endothelin receptors ETA and ETB are highly expressed in lung and skin tumor tissues . In contrast , there are few reports on endothelin signalling in the proliferation of head and neck cancer . We found that both ETA and ETB endothelin receptors were overexpressed in tumor cells of tongue cancer samples by immunohistochemistry . ETA and ETB were expressed in cultured lingual and esophageal squamous cell carcinoma ( SCCs ) cell lines . When both cultured cell lines were treated with an ETA selective antagonist ( BQ123 ) or an ETB selective antagonist ( BQ788 ) , inhibition of cell growth was observed . Similar results were observed when SCCs were treated with specific siRNA for the suppression of ETA or ETB . Furthermore , inhibition of the mitogen-activated protein ( MAP ) kinase pathway by the treatments with ET receptor antagonists and siRNA was also observed . These results indicate that endothelin signalling may , in part , play important roles in cell growth in SCCs through the MAP kinase pathway .
    OUTPUT:
