human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Tumor aerobic glycolysis , or the Warburg effect , plays important roles in tumor survival , growth , and metastasis . Pyruvate kinase isoenzyme M2 ( PKM2 ) is a key enzyme that regulates aerobic glycolysis in tumor cells . Recent research has shown that PKM2 can be used as a tumor marker for diagnosis and , in particular , as a potential target for cancer therapy . We investigated the effects of combining shRNA targeting PKM2 and docetaxel on human A549 lung carcinoma cells both in vivo and in vitro . We observed that the shRNA can significantly downregulate the expression level of PKM2 . The decrease of PKM2 resulted in a decrease in ATP synthesis , which caused intracellular accumulation of docetaxel . Furthermore , the combination of pshRNA-pkm2 and docetaxel inhibited tumor growth and promoted more cancer cell apoptosis both in vivo and in vitro . Our findings suggest that targeting tumor glycolysis can increase the efficacy of chemotherapy . In particular , the targeting of PKM2 could , to some extent , be a new way of reversing chemotherapy resistance to cancer therapy .
    OUTPUT:

agent
cellular energetics
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Tumor aerobic glycolysis , or the Warburg effect , plays important roles in tumor survival , growth , and metastasis . Pyruvate kinase isoenzyme M2 ( PKM2 ) is a key enzyme that regulates aerobic glycolysis in tumor cells . Recent research has shown that PKM2 can be used as a tumor marker for diagnosis and , in particular , as a potential target for cancer therapy . We investigated the effects of combining shRNA targeting PKM2 and docetaxel on human A549 lung carcinoma cells both in vivo and in vitro . We observed that the shRNA can significantly downregulate the expression level of PKM2 . The decrease of PKM2 resulted in a decrease in ATP synthesis , which caused intracellular accumulation of docetaxel . Furthermore , the combination of pshRNA-pkm2 and docetaxel inhibited tumor growth and promoted more cancer cell apoptosis both in vivo and in vitro . Our findings suggest that targeting tumor glycolysis can increase the efficacy of chemotherapy . In particular , the targeting of PKM2 could , to some extent , be a new way of reversing chemotherapy resistance to cancer therapy .
    OUTPUT:
