human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The hypoxic tumor microenvironment is associated with malignant progression and poor treatment response . The glucose transporter Glut-1 is a prognostic factor and putative hypoxia marker . So far , studies of Glut-1 in cancer have utilized conventional immunohistochemical analysis in a series of individual biopsy or surgical specimens . Tissue microarrays , however , provide a rapid , inexpensive means of profiling biomarker expression . To evaluate hypoxia markers , tissue cores must show the architectural features of hypoxia ; i.e. viable tissue surrounding necrotic regions . Glut-1 may be a useful biomarker to validate tissue microarrays for use in studies of hypoxia-regulated genes in cancer . In this study , we carried out immunohistochemical detection of Glut-1 protein in many tumor and normal tissue types in a range of tissue microarrays . Glut-1 was frequently found in peri-necrotic regions , occurring in 9/34 lymphomas , 6/12 melanomas , and 5/16 glioblastomas ; and in 43/54 lung , 22/84 colon , and 23/60 ovarian tumors . Expression was rare in breast ( 6/40 ) and prostate ( 1/57 ) tumors , and in normal tissue , was restricted to spleen , tongue , and CNS endothelium . In conclusion , tissue microarrays enable the observation of Glut-1 expression in peri-necrotic regions , which may be linked to hypoxia , and reflect previous studies showing differential Glut-1 expression across tumor types and non-malignant tissue .
    OUTPUT:

agent
resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The hypoxic tumor microenvironment is associated with malignant progression and poor treatment response . The glucose transporter Glut-1 is a prognostic factor and putative hypoxia marker . So far , studies of Glut-1 in cancer have utilized conventional immunohistochemical analysis in a series of individual biopsy or surgical specimens . Tissue microarrays , however , provide a rapid , inexpensive means of profiling biomarker expression . To evaluate hypoxia markers , tissue cores must show the architectural features of hypoxia ; i.e. viable tissue surrounding necrotic regions . Glut-1 may be a useful biomarker to validate tissue microarrays for use in studies of hypoxia-regulated genes in cancer . In this study , we carried out immunohistochemical detection of Glut-1 protein in many tumor and normal tissue types in a range of tissue microarrays . Glut-1 was frequently found in peri-necrotic regions , occurring in 9/34 lymphomas , 6/12 melanomas , and 5/16 glioblastomas ; and in 43/54 lung , 22/84 colon , and 23/60 ovarian tumors . Expression was rare in breast ( 6/40 ) and prostate ( 1/57 ) tumors , and in normal tissue , was restricted to spleen , tongue , and CNS endothelium . In conclusion , tissue microarrays enable the observation of Glut-1 expression in peri-necrotic regions , which may be linked to hypoxia , and reflect previous studies showing differential Glut-1 expression across tumor types and non-malignant tissue .
    OUTPUT:
