human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Recently , we identified the " apoptotic ring, " containing phosphorylated histone H2AX ( Î³-H2AX ) , as an early chromatin modification during apoptosis . Because Î³-H2AX initiates the DNA damage response ( DDR ) , we tested whether the apoptotic H2AX response leads to the full recruitment of the DDR factors that normally coordinate DNA repair and cell-cycle checkpoints . We show that the apoptotic H2AX response does not recruit the DDR factors because MDC1 ( mediator of DNA damage checkpoint protein 1 ) , which normally binds to Î³-H2AX in response to DNA damage and amplifies the DDR , is cleaved by caspase-3 . This cleavage separates the BRCT and FHA domains of MDC1 and constitutes a novel mechanism for the inactivation of DNA repair in apoptotic cells . Also , we show that downregulation of MDC1 increases the apoptotic response to TRAIL . Together , these results implicate MDC1 in the cellular apoptotic response .
    OUTPUT:

agent
genomic instability and mutation;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Recently , we identified the " apoptotic ring, " containing phosphorylated histone H2AX ( Î³-H2AX ) , as an early chromatin modification during apoptosis . Because Î³-H2AX initiates the DNA damage response ( DDR ) , we tested whether the apoptotic H2AX response leads to the full recruitment of the DDR factors that normally coordinate DNA repair and cell-cycle checkpoints . We show that the apoptotic H2AX response does not recruit the DDR factors because MDC1 ( mediator of DNA damage checkpoint protein 1 ) , which normally binds to Î³-H2AX in response to DNA damage and amplifies the DDR , is cleaved by caspase-3 . This cleavage separates the BRCT and FHA domains of MDC1 and constitutes a novel mechanism for the inactivation of DNA repair in apoptotic cells . Also , we show that downregulation of MDC1 increases the apoptotic response to TRAIL . Together , these results implicate MDC1 in the cellular apoptotic response .
    OUTPUT:
