human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: A growing number of studies have demonstrated an association between serum levels of insulin-like growth factors ( IGFs ) and IGF binding protein-3 ( IGFBP-3 ) and increased risk for various cancers . The aim of this study was to evaluate the relationship between levels of IGF-II or IGFBP-3 in cervical scrapes with cervical cancer and precancerous lesions : low-grade squamous intraepithelial lesion ( LSIL ) and high-grade squamous intraepithelial lesion ( HSIL). 4 groups of cases were examined : LSIL ( n=20 ) , HSIL ( n=28 ) , cervical cancer ( n=45 ) , and controls ( n=51 ) . Control subjects were women with normal , HPV DNA-negative Papanicolau ( Pap ) test . IGF-II and IGFBP-3 levels in cervical scrapes were measured by ELISA . Results show that median protein levels of IGF-II were significantly lower in cervical cancer cases vs. controls ( 446.5 ng/mg vs. 1,168.6 ng/mg , p&lt;0.001 ) . Significantly higher values of IGFBP-3 were found in HSIL vs. controls ( median : 549.5 ng/mg vs. 216 ng/mg ; p=0.018 ) , and were not affected by HR HPV infection , meanwhile no significant differences were observed in IGFBP-3 levels between LSIL or cervical cancer as compared to controls . These data suggests that the progression to cervical cancer is associated with alterations in the IGF system and not affected by HR HPV infection . More studies are needed to understand the possible role of IGFBP-3 in cervical carcinogenesis .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: A growing number of studies have demonstrated an association between serum levels of insulin-like growth factors ( IGFs ) and IGF binding protein-3 ( IGFBP-3 ) and increased risk for various cancers . The aim of this study was to evaluate the relationship between levels of IGF-II or IGFBP-3 in cervical scrapes with cervical cancer and precancerous lesions : low-grade squamous intraepithelial lesion ( LSIL ) and high-grade squamous intraepithelial lesion ( HSIL). 4 groups of cases were examined : LSIL ( n=20 ) , HSIL ( n=28 ) , cervical cancer ( n=45 ) , and controls ( n=51 ) . Control subjects were women with normal , HPV DNA-negative Papanicolau ( Pap ) test . IGF-II and IGFBP-3 levels in cervical scrapes were measured by ELISA . Results show that median protein levels of IGF-II were significantly lower in cervical cancer cases vs. controls ( 446.5 ng/mg vs. 1,168.6 ng/mg , p&lt;0.001 ) . Significantly higher values of IGFBP-3 were found in HSIL vs. controls ( median : 549.5 ng/mg vs. 216 ng/mg ; p=0.018 ) , and were not affected by HR HPV infection , meanwhile no significant differences were observed in IGFBP-3 levels between LSIL or cervical cancer as compared to controls . These data suggests that the progression to cervical cancer is associated with alterations in the IGF system and not affected by HR HPV infection . More studies are needed to understand the possible role of IGFBP-3 in cervical carcinogenesis .
    OUTPUT:
