human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Levels of regulatory T cells ( Tregs ) are increased in different cancer types as well as in inflammatory diseases , such as rheumatoid arthritis . Treg accumulation may result from aberrant proliferation and trafficking as well as greater resilience to oxidative stress compared with conventional T cells . This enhanced antioxidative capacity of Tregs possibly serves as feedback inhibition during inflammation and prevents uncontrolled immune reactions by favoring survival of suppressor rather than effector cells . In this study , we demonstrate that human Tregs express and secrete higher levels of thioredoxin-1 , a major antioxidative molecule . Thioredoxin-1 has an essential role in maintaining their surface thiol density as the first line of antioxidative defense mechanisms and is sensitive to proinflammatory stimuli , mainly tumor necrosis factor-Î± , in a nuclear factor-ÎºB-dependent fashion . The antiapoptotic and oncogenic potential of ( secreted ) Trx-1 suggests that it may exert effects in Tregs beyond redox regulation .
    OUTPUT:

agent
tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Levels of regulatory T cells ( Tregs ) are increased in different cancer types as well as in inflammatory diseases , such as rheumatoid arthritis . Treg accumulation may result from aberrant proliferation and trafficking as well as greater resilience to oxidative stress compared with conventional T cells . This enhanced antioxidative capacity of Tregs possibly serves as feedback inhibition during inflammation and prevents uncontrolled immune reactions by favoring survival of suppressor rather than effector cells . In this study , we demonstrate that human Tregs express and secrete higher levels of thioredoxin-1 , a major antioxidative molecule . Thioredoxin-1 has an essential role in maintaining their surface thiol density as the first line of antioxidative defense mechanisms and is sensitive to proinflammatory stimuli , mainly tumor necrosis factor-Î± , in a nuclear factor-ÎºB-dependent fashion . The antiapoptotic and oncogenic potential of ( secreted ) Trx-1 suggests that it may exert effects in Tregs beyond redox regulation .
    OUTPUT:
