human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Surgery is the most effective therapy for cancer in the United States , but disease still recurs in more than 40% of patients within 5 years after resection . Chemotherapy is given postoperatively to prevent relapses ; however , this approach has had marginal success . After surgery , recurrent tumors depend on rapid neovascular proliferation to deliver nutrients and oxygen . Phosphatidylserine ( PS ) is exposed on the vascular endothelial cells in the tumor microenvironment but is notably absent on blood vessels in normal tissues . Thus , PS is an attractive target for cancer therapy after surgery . Syngeneic mice bearing TC1 lung cancer tumors were treated with mch1N11 ( a novel mouse chimeric monoclonal antibody that targets PS ) , cisplatin ( cis ) , or combination after surgery . Tumor relapses and disease progression were decreased 90% by combination therapy compared with a 50% response rate for cis alone ( P = .02 ) . Mice receiving postoperative mch1N11 had no wound-related complications or added systemic toxicity in comparison to control animals . Mechanistic studies demonstrated that the effects of mch1N11 were associated with a dense infiltration of inflammatory cells , particularly granulocytes . This strategy was independent of the adaptive immune system . Together , these data suggest that vascular-targeted strategies directed against exposed PS may be a powerful adjunct to postoperative chemotherapy in preventing relapses after cancer surgery .
    OUTPUT:

agent
tumor promoting inflammation;inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Surgery is the most effective therapy for cancer in the United States , but disease still recurs in more than 40% of patients within 5 years after resection . Chemotherapy is given postoperatively to prevent relapses ; however , this approach has had marginal success . After surgery , recurrent tumors depend on rapid neovascular proliferation to deliver nutrients and oxygen . Phosphatidylserine ( PS ) is exposed on the vascular endothelial cells in the tumor microenvironment but is notably absent on blood vessels in normal tissues . Thus , PS is an attractive target for cancer therapy after surgery . Syngeneic mice bearing TC1 lung cancer tumors were treated with mch1N11 ( a novel mouse chimeric monoclonal antibody that targets PS ) , cisplatin ( cis ) , or combination after surgery . Tumor relapses and disease progression were decreased 90% by combination therapy compared with a 50% response rate for cis alone ( P = .02 ) . Mice receiving postoperative mch1N11 had no wound-related complications or added systemic toxicity in comparison to control animals . Mechanistic studies demonstrated that the effects of mch1N11 were associated with a dense infiltration of inflammatory cells , particularly granulocytes . This strategy was independent of the adaptive immune system . Together , these data suggest that vascular-targeted strategies directed against exposed PS may be a powerful adjunct to postoperative chemotherapy in preventing relapses after cancer surgery .
    OUTPUT:
