human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The role of inflammatory cytokine interleukin-20 ( IL-20 ) has not yet been studied in cancer biology . Here , we demonstrated up-regulation of both IL-20 and IL-20R1 in muscle invasive bladder cancer ( MIBC ) patients . The expressions of IL-20 and IL-20R1 were observed in bladder cancer 5637 and T-24 cells . We found that IL-20 significantly increased the expression of matrix metalloproteinase ( MMP)-9 via binding activity of NF-ÎºB and AP-1 in bladder cancer cells and stimulated the activation of ERK1/2 , JNK , p38MAPK , and Jak-Stat signaling . Among the pathways examined , only ERK1/2 inhibitor U0126 significantly inhibited IL-20-induced migration and invasion . Moreover , siRNA knockdown of IL-20R1 suppressed migration , invasion , ERK1/2 activation , and NF-ÎºB-mediated MMP-9 expression induced by IL-20 . Unexpectedly , cell cycle inhibitor p21WAF1 was induced by IL-20 treatment without altering cell cycle progression . Blockade of p21WAF1 function by siRNA reversed migration , invasion , activation of ERK signaling , MMP-9 expression , and activation of NF-ÎºB in IL-20-treated cells . In addition , IL-20 induced the activation of IKK , the degradation and phosphorylation of IÎºBa , and NF-ÎºB p65 nuclear translocation , which was regulated by ERK1/2 . IL-20 stimulated the recruitment of p65 to the MMP-9 promoter region . Finally , the IL-20-induced migration and invasion of cells was confirmed by IL-20 gene transfection and by addition of anti-IL-20 antibody . This is the first report that p21WAF1 is involved in ERK1/2-mediated MMP-9 expression via increased binding activity of NF-ÎºB , which resulted in the induction of migration in IL-20/IL-20R1 dyad-induced bladder cancer cells . These unexpected results might provide a critical new target for the treatment of bladder cancer .
    OUTPUT:

agent
activating invasion and metastasis;evading growth suppressors;sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The role of inflammatory cytokine interleukin-20 ( IL-20 ) has not yet been studied in cancer biology . Here , we demonstrated up-regulation of both IL-20 and IL-20R1 in muscle invasive bladder cancer ( MIBC ) patients . The expressions of IL-20 and IL-20R1 were observed in bladder cancer 5637 and T-24 cells . We found that IL-20 significantly increased the expression of matrix metalloproteinase ( MMP)-9 via binding activity of NF-ÎºB and AP-1 in bladder cancer cells and stimulated the activation of ERK1/2 , JNK , p38MAPK , and Jak-Stat signaling . Among the pathways examined , only ERK1/2 inhibitor U0126 significantly inhibited IL-20-induced migration and invasion . Moreover , siRNA knockdown of IL-20R1 suppressed migration , invasion , ERK1/2 activation , and NF-ÎºB-mediated MMP-9 expression induced by IL-20 . Unexpectedly , cell cycle inhibitor p21WAF1 was induced by IL-20 treatment without altering cell cycle progression . Blockade of p21WAF1 function by siRNA reversed migration , invasion , activation of ERK signaling , MMP-9 expression , and activation of NF-ÎºB in IL-20-treated cells . In addition , IL-20 induced the activation of IKK , the degradation and phosphorylation of IÎºBa , and NF-ÎºB p65 nuclear translocation , which was regulated by ERK1/2 . IL-20 stimulated the recruitment of p65 to the MMP-9 promoter region . Finally , the IL-20-induced migration and invasion of cells was confirmed by IL-20 gene transfection and by addition of anti-IL-20 antibody . This is the first report that p21WAF1 is involved in ERK1/2-mediated MMP-9 expression via increased binding activity of NF-ÎºB , which resulted in the induction of migration in IL-20/IL-20R1 dyad-induced bladder cancer cells . These unexpected results might provide a critical new target for the treatment of bladder cancer .
    OUTPUT:
