human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: In order to increase the permeability of cell membranes for low doses of cytostatic drugs , two bioelectrochemical methods have been compared : ( a ) electric pore formation in the plasma membranes by single electric impulses ( electroporation ) , and ( b ) reordering of membrane structure by alternating currents ( capacitively coupled ) . These treatments were applied to human leukemic K-562 cells and human lymphoma U-937 cells , yielding apoptotic and necrotic effects , determined by flow cytometry . Additional cell death occurs after exposure to light irradiation at wavelengths lambda &gt ; 600 nm , of cells which were electroporated and had incorporated actinomycin-C or daunomycin ( daunorubicin ) . It is observed that drug uptake after an exponentially decaying electroporation pulse of the initial field strength Eo=1.4 kV/cm and pulse time constants in the time range 0.5-3 ms is faster than during PEMF-treatment , i.e. , application of an alternating current of 16 kHz , voltage U&lt;100 V , I=55 mA , and exposure time 20 min . However , at the low a.c. voltage of this treatment , more apoptotic and necrotic cells are produced as compared to the electroporation treatment with one exponentially decaying voltage pulse . Thus , additional photodynamic action appears to be more effective than solely drugs and electroporation as applied in clinical electrochemotherapy , and more effective than the noninvasive pulsed electromagnetic fields ( PEMFs ) , for cancer cells in general and animals bearing tumors in particular .
    OUTPUT:

agent
resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: In order to increase the permeability of cell membranes for low doses of cytostatic drugs , two bioelectrochemical methods have been compared : ( a ) electric pore formation in the plasma membranes by single electric impulses ( electroporation ) , and ( b ) reordering of membrane structure by alternating currents ( capacitively coupled ) . These treatments were applied to human leukemic K-562 cells and human lymphoma U-937 cells , yielding apoptotic and necrotic effects , determined by flow cytometry . Additional cell death occurs after exposure to light irradiation at wavelengths lambda &gt ; 600 nm , of cells which were electroporated and had incorporated actinomycin-C or daunomycin ( daunorubicin ) . It is observed that drug uptake after an exponentially decaying electroporation pulse of the initial field strength Eo=1.4 kV/cm and pulse time constants in the time range 0.5-3 ms is faster than during PEMF-treatment , i.e. , application of an alternating current of 16 kHz , voltage U&lt;100 V , I=55 mA , and exposure time 20 min . However , at the low a.c. voltage of this treatment , more apoptotic and necrotic cells are produced as compared to the electroporation treatment with one exponentially decaying voltage pulse . Thus , additional photodynamic action appears to be more effective than solely drugs and electroporation as applied in clinical electrochemotherapy , and more effective than the noninvasive pulsed electromagnetic fields ( PEMFs ) , for cancer cells in general and animals bearing tumors in particular .
    OUTPUT:
