human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Certain mutations in BRCA1 and BRCA2 genes are frequent in the Ashkenazi Jewish population . Several factors contribute to this increased frequency , including consanguineous marriages and an event known as a " bottleneck " , which occurred in the past and caused a drastic reduction in the genetic variability of this population . Several studies were performed over the years in an attempt to elucidate the role of BRCA1 and BRCA2 genes in susceptibility to breast cancer . The aim of this study was to estimate the carrier frequency of certain common mutations in the BRCA1 ( 185delAG and 5382insC ) and BRCA2 ( 6174delT ) genes in an Ashkenazi Jewish population from Porto Alegre , Brazil . Molecular analyses were done by PCR followed by RFLP ( ACRS ) . The carrier frequencies for BRCA1 185delAG and 5382insC were 0.78 and 0 respectively , and 0.4 for the BRCA2 6174deT mutation . These findings are similar to those of some prior studies but differ from others , possibly due to excluding individuals with a personal or family history of cancer . Our sample was drawn from the community group and included individuals with or without a family or personal history of cancer . Furthermore , increased dispersion among Ashkenazi subpopulations may be the result of strong genetic drift and/or admixture . It is therefore necessary to consider the effects of local admixture on the mismatch distributions of various Jewish populations .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Certain mutations in BRCA1 and BRCA2 genes are frequent in the Ashkenazi Jewish population . Several factors contribute to this increased frequency , including consanguineous marriages and an event known as a " bottleneck " , which occurred in the past and caused a drastic reduction in the genetic variability of this population . Several studies were performed over the years in an attempt to elucidate the role of BRCA1 and BRCA2 genes in susceptibility to breast cancer . The aim of this study was to estimate the carrier frequency of certain common mutations in the BRCA1 ( 185delAG and 5382insC ) and BRCA2 ( 6174delT ) genes in an Ashkenazi Jewish population from Porto Alegre , Brazil . Molecular analyses were done by PCR followed by RFLP ( ACRS ) . The carrier frequencies for BRCA1 185delAG and 5382insC were 0.78 and 0 respectively , and 0.4 for the BRCA2 6174deT mutation . These findings are similar to those of some prior studies but differ from others , possibly due to excluding individuals with a personal or family history of cancer . Our sample was drawn from the community group and included individuals with or without a family or personal history of cancer . Furthermore , increased dispersion among Ashkenazi subpopulations may be the result of strong genetic drift and/or admixture . It is therefore necessary to consider the effects of local admixture on the mismatch distributions of various Jewish populations .
    OUTPUT:
