human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Previous studies have demonstrated that mesenchymal stromal cells ( MSCs ) enhance cell survival through upregulation and secretion of stanniocalcin-1 ( STC1 ) . This study shows that MSC-derived STC1 promotes survival of lung cancer cells by uncoupling oxidative phosphorylation , reducing intracellular reactive oxygen species ( ROS ) , and shifting metabolism towards a more glycolytic metabolic profile . MSC-derived STC1 upregulated uncoupling protein 2 ( UCP2 ) in injured A549 cells in an STC1-dependent manner . Knockdown of UCP2 reduced the ability of MSCs and recombinant STC1 ( rSTC1 ) to reduce cell death in the A549 population. rSTC1-treated A549 cells displayed decreased levels of ROS , mitochondrial membrane potential ( MMP ) , and increased lactate production , all of which were dependent on the upregulation of UCP2 . Our data suggest that MSCs can promote cell survival by regulating mitochondrial respiration via STC1 .
    OUTPUT:

agent
cellular energetics;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Previous studies have demonstrated that mesenchymal stromal cells ( MSCs ) enhance cell survival through upregulation and secretion of stanniocalcin-1 ( STC1 ) . This study shows that MSC-derived STC1 promotes survival of lung cancer cells by uncoupling oxidative phosphorylation , reducing intracellular reactive oxygen species ( ROS ) , and shifting metabolism towards a more glycolytic metabolic profile . MSC-derived STC1 upregulated uncoupling protein 2 ( UCP2 ) in injured A549 cells in an STC1-dependent manner . Knockdown of UCP2 reduced the ability of MSCs and recombinant STC1 ( rSTC1 ) to reduce cell death in the A549 population. rSTC1-treated A549 cells displayed decreased levels of ROS , mitochondrial membrane potential ( MMP ) , and increased lactate production , all of which were dependent on the upregulation of UCP2 . Our data suggest that MSCs can promote cell survival by regulating mitochondrial respiration via STC1 .
    OUTPUT:
