human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE The goal of this study was to investigate the relationship between plasma levels of insulin-like growth factors-1 ( IGF-1 ) and IGF-binding protein-3 ( IGFBP-3 ) and the risk for cervical intraepithelial neoplasia ( CIN ) and cervical cancer . METHODS Plasma levels of IGF-1 and IGFBP-3 of 44 cervical cancer patients , 82 CIN patients and 40 neoplasm-free patients were investigated . Then the associations of the plasma levels of IGF-1 and IGFBP-3 with cervical neoplasm or its clinicopathologic parameters were analyzed . RESULTS The mean IGF-1 concentrations were significantly different among the control , CIN , and cervical cancer groups ; the levels were higher in the CIN group compared to the controls . According to the quartile category , the plasma IGF-1 level was significantly higher ( p=0.0015 ) in the CIN group than in the controls . The IGFBP-3 level showed no association between the controls and CIN groups ( p=0.842 ) . Although the mean IGF-1/IGFBP-3 molar ratio had borderline significance ( p=0.08 ) among the study population , the quartile comparison showed a significantly higher IGF-1/IGFBP-3 molar ratio in the CIN group compared to the control group ( p=0.041 ) . CONCLUSION Plasma levels of IGF-1 and the IGF-1/IGFBP-3 molar ratio might be useful for the development early detection of cervical lesions and used as an adjuvant diagnostic tool for cervical neoplasia after more larger scale research .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: OBJECTIVE The goal of this study was to investigate the relationship between plasma levels of insulin-like growth factors-1 ( IGF-1 ) and IGF-binding protein-3 ( IGFBP-3 ) and the risk for cervical intraepithelial neoplasia ( CIN ) and cervical cancer . METHODS Plasma levels of IGF-1 and IGFBP-3 of 44 cervical cancer patients , 82 CIN patients and 40 neoplasm-free patients were investigated . Then the associations of the plasma levels of IGF-1 and IGFBP-3 with cervical neoplasm or its clinicopathologic parameters were analyzed . RESULTS The mean IGF-1 concentrations were significantly different among the control , CIN , and cervical cancer groups ; the levels were higher in the CIN group compared to the controls . According to the quartile category , the plasma IGF-1 level was significantly higher ( p=0.0015 ) in the CIN group than in the controls . The IGFBP-3 level showed no association between the controls and CIN groups ( p=0.842 ) . Although the mean IGF-1/IGFBP-3 molar ratio had borderline significance ( p=0.08 ) among the study population , the quartile comparison showed a significantly higher IGF-1/IGFBP-3 molar ratio in the CIN group compared to the control group ( p=0.041 ) . CONCLUSION Plasma levels of IGF-1 and the IGF-1/IGFBP-3 molar ratio might be useful for the development early detection of cervical lesions and used as an adjuvant diagnostic tool for cervical neoplasia after more larger scale research .
    OUTPUT:
