human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE To evaluate the difference of angiogenic factors PDGF/dThdPase,VEGF expression and microvessel density ( MVD ) in primary hypopharyngeal tumor and metastasis lymph nodes . METHOD The author studied immunohistochemically a series of 48 primary hypopharyngeal carcinoma patients and metastasis lymph nodes were calculated . RESULT The percentage of VEGF was 25.38% in primary tumor and 21.52% in lymph nodes . No significant difference was found . The percentage of PDGF/dThdPase was 29.59% in primary tumor and and 21.2% in lymph nodes . This showed significent difference . VEGF showed significent difference between live and death group(P &lt ; 0.05 ) and among differentiation group ( P &lt ; 0.05 ) . MVD showed significant difference between live and death group , early and late stage group , and T1-2 and T3-4 group ( P &lt ; 0.05 ) . There were statistically significant correlations between the score of PDGF/ dThdPase , or VEGF and the score of MVD respectively . CONCLUSION The present study suggests that there was a correlation between VEGF or PDGF and MVD . VEGF and MVD were possible to be prognostic discriminators in hypopharyngeal carcinoma . PDGF expression in lymph nodes was significant higher than in primary tumors , and MVD expression in primary tumor was significant higher than in lymph nodes .
    OUTPUT:

agent
inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE To evaluate the difference of angiogenic factors PDGF/dThdPase,VEGF expression and microvessel density ( MVD ) in primary hypopharyngeal tumor and metastasis lymph nodes . METHOD The author studied immunohistochemically a series of 48 primary hypopharyngeal carcinoma patients and metastasis lymph nodes were calculated . RESULT The percentage of VEGF was 25.38% in primary tumor and 21.52% in lymph nodes . No significant difference was found . The percentage of PDGF/dThdPase was 29.59% in primary tumor and and 21.2% in lymph nodes . This showed significent difference . VEGF showed significent difference between live and death group(P &lt ; 0.05 ) and among differentiation group ( P &lt ; 0.05 ) . MVD showed significant difference between live and death group , early and late stage group , and T1-2 and T3-4 group ( P &lt ; 0.05 ) . There were statistically significant correlations between the score of PDGF/ dThdPase , or VEGF and the score of MVD respectively . CONCLUSION The present study suggests that there was a correlation between VEGF or PDGF and MVD . VEGF and MVD were possible to be prognostic discriminators in hypopharyngeal carcinoma . PDGF expression in lymph nodes was significant higher than in primary tumors , and MVD expression in primary tumor was significant higher than in lymph nodes .
    OUTPUT:
