human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Deregulation of insulin-like growth factor-1 receptor ( IGF-1R ) is closely associated with malignant transformation and tumor cell survival in various cancers . We found that IGF-1R expression level in leukemia cells positively correlated with the percentage of blast in bone marrow from de novo acute myeloid leukemia ( AML ) patients . Moreover , we showed that NVP-ADW742 , a novel small weight molecular inhibitor of IGF-IR , could induce apoptosis in both HL-60 cell line and primary AML blasts . However , no significant alteration of cell cycle was observed in HL-60 cells . Further studies revealed that NVP-ADW742 induced Akt dephosphorylation , which might subsequently induce p38 phosphorylation and decrease antiapoptotic protein Bcl-2 expression in HL-60 cells . Finally , we demonstrated that NVP-ADW742 could synergize with Ara-C to induce the kill in a subset of drug-resistant AML specimens . We suggested that IGF-lR targeting might be therapeutically beneficial for some AML patients .
    OUTPUT:

agent
sustaining proliferative signaling;resisting cell death;evading growth suppressors
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Deregulation of insulin-like growth factor-1 receptor ( IGF-1R ) is closely associated with malignant transformation and tumor cell survival in various cancers . We found that IGF-1R expression level in leukemia cells positively correlated with the percentage of blast in bone marrow from de novo acute myeloid leukemia ( AML ) patients . Moreover , we showed that NVP-ADW742 , a novel small weight molecular inhibitor of IGF-IR , could induce apoptosis in both HL-60 cell line and primary AML blasts . However , no significant alteration of cell cycle was observed in HL-60 cells . Further studies revealed that NVP-ADW742 induced Akt dephosphorylation , which might subsequently induce p38 phosphorylation and decrease antiapoptotic protein Bcl-2 expression in HL-60 cells . Finally , we demonstrated that NVP-ADW742 could synergize with Ara-C to induce the kill in a subset of drug-resistant AML specimens . We suggested that IGF-lR targeting might be therapeutically beneficial for some AML patients .
    OUTPUT:
