human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: By using the rat azoxymethane ( AOM)-induced colon carcinogenesis model , which mirrors many clinical features of human colorectal cancer , we examined whether genetic changes occurring early in colonic mucosa are predictive of treatment efficacy . In the present study the administration of the chemopreventive agent lupulone over the course of 7 weeks postinitiation reduced the number of preneoplastic lesions in the colonic mucosa by 50% . At the molecular level we observed the downregulation of genes involved in the inflammatory response , including IL-1Î² and TNF-Î± , and of matrix metalloproteinase-7 gene and protein expression . We also observed a substantial upregulation of components of the innate immune system , Î±-defensin-5 and lipocalin 2 . Lupulone induced the expression of apoptosis-related genes and caused a reversal of the B-cell lymphoma/leukemia 2 ( Bcl-2 ; antiapoptotic ) to Bcl-2 associated X protein ( Bax ; proapoptotic ) transcript and protein ratios ( Bcl-2/Bax &gt ; 1 in AOM controls and Bcl-2/Bax &lt ; 1 in lupulone-treated AOM rats ) . Here , we identify several target genes that could be considered early biomarkers of colon carcinogenesis and indicative of drug efficacy .
    OUTPUT:

agent
tumor promoting inflammation;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: By using the rat azoxymethane ( AOM)-induced colon carcinogenesis model , which mirrors many clinical features of human colorectal cancer , we examined whether genetic changes occurring early in colonic mucosa are predictive of treatment efficacy . In the present study the administration of the chemopreventive agent lupulone over the course of 7 weeks postinitiation reduced the number of preneoplastic lesions in the colonic mucosa by 50% . At the molecular level we observed the downregulation of genes involved in the inflammatory response , including IL-1Î² and TNF-Î± , and of matrix metalloproteinase-7 gene and protein expression . We also observed a substantial upregulation of components of the innate immune system , Î±-defensin-5 and lipocalin 2 . Lupulone induced the expression of apoptosis-related genes and caused a reversal of the B-cell lymphoma/leukemia 2 ( Bcl-2 ; antiapoptotic ) to Bcl-2 associated X protein ( Bax ; proapoptotic ) transcript and protein ratios ( Bcl-2/Bax &gt ; 1 in AOM controls and Bcl-2/Bax &lt ; 1 in lupulone-treated AOM rats ) . Here , we identify several target genes that could be considered early biomarkers of colon carcinogenesis and indicative of drug efficacy .
    OUTPUT:
