human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Overexpression/amplification of human epidermal growth factor receptor ( HER)2/neu ( erbB-2 ) oncogene plays a causal role in carcinogenesis and correlates with a poor clinical prognosis . However , little is known about HER2 in gastric cancer . In this study , we explored the pharmacological activities of natural triterpenoid corosolic acid ( CRA ) in HER2 signaling and its role in gastric cancer development and progression . In this study , CRA dramatically inhibited HER2 expression in a dose- and time-dependent manner , effectively inhibited cell proliferation , and induced G(0)/G(1) arrest through the induction of p27(kip1) and cyclin D(1) down-regulation . CRA exposure enhanced apoptotic cell death , as confirmed by caspase-3 and poly ( ADP-ribose ) polymerase cleavage activities . CRA inhibited signaling pathways downstream of HER2 , including phospho-proteins such as Akt and Erk . In addition , CRA combined with adriamycin and 5-fluorouracil enhanced this growth inhibition , but not with docetaxel and paclitaxel . These findings demonstrate that CRA suppresses HER2 expression , which in turn promotes cell cycle arrest and apoptotic cell death of gastric cancer cells , providing a rationale for future clinical trials of CRA in the treatment of HER2-positive gastric cancers .
    OUTPUT:

agent
evading growth suppressors;sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Overexpression/amplification of human epidermal growth factor receptor ( HER)2/neu ( erbB-2 ) oncogene plays a causal role in carcinogenesis and correlates with a poor clinical prognosis . However , little is known about HER2 in gastric cancer . In this study , we explored the pharmacological activities of natural triterpenoid corosolic acid ( CRA ) in HER2 signaling and its role in gastric cancer development and progression . In this study , CRA dramatically inhibited HER2 expression in a dose- and time-dependent manner , effectively inhibited cell proliferation , and induced G(0)/G(1) arrest through the induction of p27(kip1) and cyclin D(1) down-regulation . CRA exposure enhanced apoptotic cell death , as confirmed by caspase-3 and poly ( ADP-ribose ) polymerase cleavage activities . CRA inhibited signaling pathways downstream of HER2 , including phospho-proteins such as Akt and Erk . In addition , CRA combined with adriamycin and 5-fluorouracil enhanced this growth inhibition , but not with docetaxel and paclitaxel . These findings demonstrate that CRA suppresses HER2 expression , which in turn promotes cell cycle arrest and apoptotic cell death of gastric cancer cells , providing a rationale for future clinical trials of CRA in the treatment of HER2-positive gastric cancers .
    OUTPUT:
