human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The NOTCH signaling pathway plays important role in the development of multicellular organisms , as it regulates cell proliferation , survival , and differentiation . In adults , it is essential for the T- or B-lymphocyte lineage commitment . NOTCH1 and FBXW7 mutations both lead the activation of the NOTCH1 pathway and are found in the majority of T-ALL patients . In this study , the mutation analysis of NOTCH1 and FBXW7 genes was performed in 87 pediatric T-ALLs who were treated on the ALL-BFM protocols . In 19 patients ( 22% ) , activating NOTCH1 mutations were observed either in the heterodimerization domain or in the PEST domain and 7 cases ( 10% ) demonstrated FBXW7 mutations ( 2 cases had both NOTCH1 and FBXW7 mutations ) . We also analyzed the relationship of the mutation data between the clinical and biological data of the patients . NOTCH1 and FBXW7 , NOTCH1 alone were found correlated with lower initial leucocyte counts which was independent from the sex and T- cell immunophenotype . However , NOTCH1 and FBXW7 mutations were not predictive of outcome in the overall cohort of pediatric T-ALLs .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The NOTCH signaling pathway plays important role in the development of multicellular organisms , as it regulates cell proliferation , survival , and differentiation . In adults , it is essential for the T- or B-lymphocyte lineage commitment . NOTCH1 and FBXW7 mutations both lead the activation of the NOTCH1 pathway and are found in the majority of T-ALL patients . In this study , the mutation analysis of NOTCH1 and FBXW7 genes was performed in 87 pediatric T-ALLs who were treated on the ALL-BFM protocols . In 19 patients ( 22% ) , activating NOTCH1 mutations were observed either in the heterodimerization domain or in the PEST domain and 7 cases ( 10% ) demonstrated FBXW7 mutations ( 2 cases had both NOTCH1 and FBXW7 mutations ) . We also analyzed the relationship of the mutation data between the clinical and biological data of the patients . NOTCH1 and FBXW7 , NOTCH1 alone were found correlated with lower initial leucocyte counts which was independent from the sex and T- cell immunophenotype . However , NOTCH1 and FBXW7 mutations were not predictive of outcome in the overall cohort of pediatric T-ALLs .
    OUTPUT:
