human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The deregulation of Met/hepatocyte growth factor ( HGF ) receptor tyrosine kinase signaling constitutes a common event in colorectal cancers . However , the physiopathological functions of such a deregulation remain poorly understood . In the present study , we investigated the role of the deregulation of Met receptor in the neoplastic transformation of intestinal epithelial cells . To do so , the normal , well-established and characterized rat intestinal epithelial IEC-6 cells were transduced with a retrovirus carrying the oncogenic constitutive active form of Met receptor , Tpr-Met . Herein , we show that compared with control IEC-6 cells , Tpr-Met-IEC-6 cells exhibit enhanced proliferation , loss of growth-contact inhibition , cell morphological alterations , actin cytoskeletal reorganization , loss of E-cadherin expression and anchorage-independent growth . Moreover , Tpr-Met-IEC-6 cells are conferred the capacity to produce the proangiogenic factor VEGF and to reduce the potent antiangiogenic factor thrombospondin-1 . Of significance , Tpr-Met-IEC-6 cells are endowed with the ability to elicit angiogenic responses and to form tumors and metastases in vivo . Hence , our study demonstrates for the first time that the sole oncogenic engagement of Met receptor in normal intestinal epithelial cells is sufficient to induce a wide array of cancerous biological processes that are fundamental to the initiation and malignant progression of colorectal cancers .
    OUTPUT:

agent
evading growth suppressors;inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The deregulation of Met/hepatocyte growth factor ( HGF ) receptor tyrosine kinase signaling constitutes a common event in colorectal cancers . However , the physiopathological functions of such a deregulation remain poorly understood . In the present study , we investigated the role of the deregulation of Met receptor in the neoplastic transformation of intestinal epithelial cells . To do so , the normal , well-established and characterized rat intestinal epithelial IEC-6 cells were transduced with a retrovirus carrying the oncogenic constitutive active form of Met receptor , Tpr-Met . Herein , we show that compared with control IEC-6 cells , Tpr-Met-IEC-6 cells exhibit enhanced proliferation , loss of growth-contact inhibition , cell morphological alterations , actin cytoskeletal reorganization , loss of E-cadherin expression and anchorage-independent growth . Moreover , Tpr-Met-IEC-6 cells are conferred the capacity to produce the proangiogenic factor VEGF and to reduce the potent antiangiogenic factor thrombospondin-1 . Of significance , Tpr-Met-IEC-6 cells are endowed with the ability to elicit angiogenic responses and to form tumors and metastases in vivo . Hence , our study demonstrates for the first time that the sole oncogenic engagement of Met receptor in normal intestinal epithelial cells is sufficient to induce a wide array of cancerous biological processes that are fundamental to the initiation and malignant progression of colorectal cancers .
    OUTPUT:
