human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: C-reactive protein is produced in response to cytokines such as interleukin ( IL)-6 . It is known that increased plasma IL-6 levels induce increased hepatic and intratumoral production of C-reactive protein . Cyclooxygenase enzyme-2 is induced by various stimuli , including inflammation and various growth factors . Expression of these two markers has not been well studied in clear cell renal cell carcinoma . The objective of this study is to correlate the expression of C-reactive protein and cyclooxygenase enzyme-2 in clear cell renal cell carcinoma with pathologic parameters . A search of the surgical pathology and consultation files at our institution was performed for nephrectomy specimens with clear cell renal cell carcinoma from 2007 to 2008 . Immunohistochemical stains for C-reactive protein and cyclooxygenase enzyme-2 were performed . Staining intensity was graded as 0 , 1+ , 2+ , and 3+ . The staining intensity was then correlated with pathologic stage and Fuhrman nuclear grade for each case . A total of 110 cases were identified . Strong expression of C-reactive protein was associated with higher Fuhrman nuclear grade and pathologic stage , and the strength of correlation was statistically significant ( pâ=â0.01 and pâ=â0.001 ) , respectively . However , cyclooxygenase enzyme-2 expression did not show statistically significant correlation with both pathologic stage and Fuhrman nuclear grade ( pâ=â0.1 and pâ=â0.15 ) , respectively . To our knowledge , this is the largest study to date correlating the expression of both C-reactive protein and cyclooxygenase enzyme-2 in tissue with pathologic parameters in patients with clear cell renal cell carcinoma , which could have significant prognostic and therapeutic implications .
    OUTPUT:

agent
tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: C-reactive protein is produced in response to cytokines such as interleukin ( IL)-6 . It is known that increased plasma IL-6 levels induce increased hepatic and intratumoral production of C-reactive protein . Cyclooxygenase enzyme-2 is induced by various stimuli , including inflammation and various growth factors . Expression of these two markers has not been well studied in clear cell renal cell carcinoma . The objective of this study is to correlate the expression of C-reactive protein and cyclooxygenase enzyme-2 in clear cell renal cell carcinoma with pathologic parameters . A search of the surgical pathology and consultation files at our institution was performed for nephrectomy specimens with clear cell renal cell carcinoma from 2007 to 2008 . Immunohistochemical stains for C-reactive protein and cyclooxygenase enzyme-2 were performed . Staining intensity was graded as 0 , 1+ , 2+ , and 3+ . The staining intensity was then correlated with pathologic stage and Fuhrman nuclear grade for each case . A total of 110 cases were identified . Strong expression of C-reactive protein was associated with higher Fuhrman nuclear grade and pathologic stage , and the strength of correlation was statistically significant ( pâ=â0.01 and pâ=â0.001 ) , respectively . However , cyclooxygenase enzyme-2 expression did not show statistically significant correlation with both pathologic stage and Fuhrman nuclear grade ( pâ=â0.1 and pâ=â0.15 ) , respectively . To our knowledge , this is the largest study to date correlating the expression of both C-reactive protein and cyclooxygenase enzyme-2 in tissue with pathologic parameters in patients with clear cell renal cell carcinoma , which could have significant prognostic and therapeutic implications .
    OUTPUT:
