human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The Punica granatum L. var. granatum ( pomegranate ) has been demonstrated to exert antitumor effects on various types of cancer cells . The present study aimed to evaluate the medicinal herbs Punica granatum L. var. spinosa ( apple punice ) that are native to Iran . This study was determined to test the possible cytotoxic activity and induction of apoptosis on human prostate cell lines . The effect of ethanol extracts of the herbs on the inhibition of cell proliferation was assessed by MTT colorimetric assay . PC3 cell lines treated with the extracts were analyzed for the induction of apoptosis by cell death detection ( ELISA ) and TUNEL assay . Dye exclusion analysis was performed for viability rate . Our results demonstrated that the Punica granatum L. var. spinosa extract dose dependently suppressed the proliferation of PC3 cells ( IC(50)= 250.21âÎ¼g/mL ) when compared with a chemotherapeutic anticancer drug ( Toxol ) ( Vesper Pharmaceuticals ) with increased nucleosome production from apoptotic cells . The Punica granatum L. var. spinosa extract attenuated the human prostate cell proliferation in vitro possibly by inducing apoptosis . The Punica granatum L. var. spinosa is likely to be valuable for the treatment of some forms of human prostate cell line .
    OUTPUT:

agent
resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The Punica granatum L. var. granatum ( pomegranate ) has been demonstrated to exert antitumor effects on various types of cancer cells . The present study aimed to evaluate the medicinal herbs Punica granatum L. var. spinosa ( apple punice ) that are native to Iran . This study was determined to test the possible cytotoxic activity and induction of apoptosis on human prostate cell lines . The effect of ethanol extracts of the herbs on the inhibition of cell proliferation was assessed by MTT colorimetric assay . PC3 cell lines treated with the extracts were analyzed for the induction of apoptosis by cell death detection ( ELISA ) and TUNEL assay . Dye exclusion analysis was performed for viability rate . Our results demonstrated that the Punica granatum L. var. spinosa extract dose dependently suppressed the proliferation of PC3 cells ( IC(50)= 250.21âÎ¼g/mL ) when compared with a chemotherapeutic anticancer drug ( Toxol ) ( Vesper Pharmaceuticals ) with increased nucleosome production from apoptotic cells . The Punica granatum L. var. spinosa extract attenuated the human prostate cell proliferation in vitro possibly by inducing apoptosis . The Punica granatum L. var. spinosa is likely to be valuable for the treatment of some forms of human prostate cell line .
    OUTPUT:
