human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: BACKGROUND To identify potential tumor suppressor genes , genome-wide data from exome and transcriptome sequencing were combined to search for genes with loss of heterozygosity and allele-specific expression . The analysis was conducted on the breast cancer cell line HCC1954 , and a lymphoblast cell line from the same individual , HCC1954BL . RESULTS By comparing exome sequences from the two cell lines , we identified loss of heterozygosity events at 403 genes in HCC1954 and at one gene in HCC1954BL . The combination of exome and transcriptome sequence data also revealed 86 and 50 genes with allele specific expression events in HCC1954 and HCC1954BL , which comprise 5.4% and 2.6% of genes surveyed , respectively . Many of these genes identified by loss of heterozygosity and allele-specific expression are known or putative tumor suppressor genes , such as BRCA1 , MSH3 and SETX , which participate in DNA repair pathways . CONCLUSIONS Our results demonstrate that the combined application of high throughput sequencing to exome and allele-specific transcriptome analysis can reveal genes with known tumor suppressor characteristics , and a shortlist of novel candidates for the study of tumor suppressor activities .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: BACKGROUND To identify potential tumor suppressor genes , genome-wide data from exome and transcriptome sequencing were combined to search for genes with loss of heterozygosity and allele-specific expression . The analysis was conducted on the breast cancer cell line HCC1954 , and a lymphoblast cell line from the same individual , HCC1954BL . RESULTS By comparing exome sequences from the two cell lines , we identified loss of heterozygosity events at 403 genes in HCC1954 and at one gene in HCC1954BL . The combination of exome and transcriptome sequence data also revealed 86 and 50 genes with allele specific expression events in HCC1954 and HCC1954BL , which comprise 5.4% and 2.6% of genes surveyed , respectively . Many of these genes identified by loss of heterozygosity and allele-specific expression are known or putative tumor suppressor genes , such as BRCA1 , MSH3 and SETX , which participate in DNA repair pathways . CONCLUSIONS Our results demonstrate that the combined application of high throughput sequencing to exome and allele-specific transcriptome analysis can reveal genes with known tumor suppressor characteristics , and a shortlist of novel candidates for the study of tumor suppressor activities .
    OUTPUT:
