human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: BACKGROUND Matrix metalloproteinases comprise a family of enzyme degrade components of extra cellular matrix . There are single nucleotide polymorphisms in the promoter regions of several genes with ability to influence cancer susceptibility . The aim of this study was to analyze association between MMP3 promoter polymorphisms and colorectal cancer occurrence and progression . MATERIALS AND METHODS In this case-control study 120 colorectal cancer patients and 100 controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) on the genomic deoxyribonucleic acid ( DNA ) . The patients group was divided into different subgroups : a subgroup without metastatic activity ( M(-) ) and a subgroup that had developed metastasis ( M(+) ) . RESULTS There was a significant difference in frequency of the MMP-3 genotype between cases and controls ( χ΂ = 16.17 ; P = 0.0003 ) . The 5A homozygote in patients and controls was significantly different . The frequency of the 5A allele among affected patients ( 67.91% ) was significantly higher than among the healthy controls ( 49% ; χ(2) = 16.17 , P = 0.00005 ) . At the time of diagnosis , individual who was carrying the 5A allele was more represented in the M(+) subgroup than in M(-) subgroup ( χ² = 7.49 ; P = 0.006 , OR = 3.86 ; 95% CI , 1.43-10.33 ) . The difference between M(-) and controls did not observe statistically significant ( χ² = 0.009 ; P = 0.92 ) . CONCLUSIONS Our results suggest that the presence of 5A polymorphism at the MMP-3 promoter region may favor the growth and the metastasis process in colorectal cancer patients and could be looked at as a risk factor for a worse prognosis .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: BACKGROUND Matrix metalloproteinases comprise a family of enzyme degrade components of extra cellular matrix . There are single nucleotide polymorphisms in the promoter regions of several genes with ability to influence cancer susceptibility . The aim of this study was to analyze association between MMP3 promoter polymorphisms and colorectal cancer occurrence and progression . MATERIALS AND METHODS In this case-control study 120 colorectal cancer patients and 100 controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) on the genomic deoxyribonucleic acid ( DNA ) . The patients group was divided into different subgroups : a subgroup without metastatic activity ( M(-) ) and a subgroup that had developed metastasis ( M(+) ) . RESULTS There was a significant difference in frequency of the MMP-3 genotype between cases and controls ( χ΂ = 16.17 ; P = 0.0003 ) . The 5A homozygote in patients and controls was significantly different . The frequency of the 5A allele among affected patients ( 67.91% ) was significantly higher than among the healthy controls ( 49% ; χ(2) = 16.17 , P = 0.00005 ) . At the time of diagnosis , individual who was carrying the 5A allele was more represented in the M(+) subgroup than in M(-) subgroup ( χ² = 7.49 ; P = 0.006 , OR = 3.86 ; 95% CI , 1.43-10.33 ) . The difference between M(-) and controls did not observe statistically significant ( χ² = 0.009 ; P = 0.92 ) . CONCLUSIONS Our results suggest that the presence of 5A polymorphism at the MMP-3 promoter region may favor the growth and the metastasis process in colorectal cancer patients and could be looked at as a risk factor for a worse prognosis .
    OUTPUT:
