human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Breast cancer is a heterogeneous disease at both the clinical and molecular levels . This heterogeneity may give rise to different therapy responses . Molecular profiling has facilitated identification of signatures for stratifying patients who would potentially benefit from given therapies . Previously , we reported on a subset of genes with the potential for predicting response of primary breast cancer to neoadjuvant chemotherapy . Herein , we report that patients with luminal ( estrogen receptor Î± [ ERÎ±]-expressing ) breast cancer were enriched for nonresponders . To identify novel factors that contribute to the survival of breast cancer cells , a loss-of-function screen was performed with a subset of genes overexpressed in patients with disease resistant to chemotherapy . This approach led us to identify protein phosphatase 1 , regulatory subunit 15B ( PPP1R15B ) as a factor with a potentially essential role in the survival of ERÎ±-positive breast cancer cells . Functional analyses showed that PPP1R15B depletion results in impaired proliferation due to unsuccessful transition of cells from G1 to S phase of the cell cycle , and apoptosis induction . Moreover , our data revealed a regulatory role for PPP1R15B in activating ERÎ± . Furthermore , a high level of PPP1R15B mRNA expression was associated with poor outcome following tamoxifen-based therapy . Accordingly , knockdown of PPP1R15B expression sensitized tamoxifen-resistant MCF-7 breast cancer cells to tamoxifen while reducing ERÎ± abundance in these cells . Our findings reveal a novel role for PPP1R15B in the survival and therapy response of ERÎ±-positive breast cancer and may open new avenues for tumor subtype-specific therapeutic strategies in the era of personalized medicine .
    OUTPUT:

agent
sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Breast cancer is a heterogeneous disease at both the clinical and molecular levels . This heterogeneity may give rise to different therapy responses . Molecular profiling has facilitated identification of signatures for stratifying patients who would potentially benefit from given therapies . Previously , we reported on a subset of genes with the potential for predicting response of primary breast cancer to neoadjuvant chemotherapy . Herein , we report that patients with luminal ( estrogen receptor Î± [ ERÎ±]-expressing ) breast cancer were enriched for nonresponders . To identify novel factors that contribute to the survival of breast cancer cells , a loss-of-function screen was performed with a subset of genes overexpressed in patients with disease resistant to chemotherapy . This approach led us to identify protein phosphatase 1 , regulatory subunit 15B ( PPP1R15B ) as a factor with a potentially essential role in the survival of ERÎ±-positive breast cancer cells . Functional analyses showed that PPP1R15B depletion results in impaired proliferation due to unsuccessful transition of cells from G1 to S phase of the cell cycle , and apoptosis induction . Moreover , our data revealed a regulatory role for PPP1R15B in activating ERÎ± . Furthermore , a high level of PPP1R15B mRNA expression was associated with poor outcome following tamoxifen-based therapy . Accordingly , knockdown of PPP1R15B expression sensitized tamoxifen-resistant MCF-7 breast cancer cells to tamoxifen while reducing ERÎ± abundance in these cells . Our findings reveal a novel role for PPP1R15B in the survival and therapy response of ERÎ±-positive breast cancer and may open new avenues for tumor subtype-specific therapeutic strategies in the era of personalized medicine .
    OUTPUT:
