human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: D-Limonene , a common monoterepene has been shown to have antiproliferative , apoptosis-inducing and chemopreventive effects . In the present study , we have investigated the effects of D-limonene on the growth of 7,12-dimethylbenz[a]anthracene ( DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate ( TPA)-promoted skin tumor development . We found that D-limonene ( 50 and 100 mg/kg body weight ) treatments to the mouse skin significantly reduced the TPA-induced ( a ) edema and hyperplasia ( p &lt ; 0.001 ) ; ( b ) expression of cyclooxygenase-2 ; ( c ) ornithine decarboxylase activity ( p &lt ; 0.001 ) ; and ( d ) [ (3)H ] thymidine incorporation into DNA ( p &lt ; 0.001 ) . In addition , treatment of D-limonene effectively restored the level of reduced glutathione , glutathione peroxidase , glutathione reductase , glutathione S-transferase , catalase and malondialdehyde production in TPA-treated mouse skin . In a two-stage skin tumorigenesis study , D-limonene significantly reduced the tumor burden ( p &lt ; 0.005 ) and tumor incidence as compared to DMBA/TPA-treated mice . D-Limonene treatment also extended the latency period of tumor development from 4 to 9 weeks . D-Limonene treatment decreased the expression level of Ras , Raf and phosphorylation of extracellular signal-regulated protein kinase 1/2 in DMBA/TPA-induced tumors . A decrease in the expression of Bcl-2 and an increase in Bax expression were also observed in tumor tissues of mice treated with D-limonene . Taken together , our findings suggest that D-limonene may exert its chemopreventive activity through the inhibition of inflammation , oxidative stress and Ras-signaling as well as the induction of pro-apoptotic state during TPA-mediated promotion of DMBA-induced skin cancer in mouse model .
    OUTPUT:

agent
tumor promoting inflammation;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: D-Limonene , a common monoterepene has been shown to have antiproliferative , apoptosis-inducing and chemopreventive effects . In the present study , we have investigated the effects of D-limonene on the growth of 7,12-dimethylbenz[a]anthracene ( DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate ( TPA)-promoted skin tumor development . We found that D-limonene ( 50 and 100 mg/kg body weight ) treatments to the mouse skin significantly reduced the TPA-induced ( a ) edema and hyperplasia ( p &lt ; 0.001 ) ; ( b ) expression of cyclooxygenase-2 ; ( c ) ornithine decarboxylase activity ( p &lt ; 0.001 ) ; and ( d ) [ (3)H ] thymidine incorporation into DNA ( p &lt ; 0.001 ) . In addition , treatment of D-limonene effectively restored the level of reduced glutathione , glutathione peroxidase , glutathione reductase , glutathione S-transferase , catalase and malondialdehyde production in TPA-treated mouse skin . In a two-stage skin tumorigenesis study , D-limonene significantly reduced the tumor burden ( p &lt ; 0.005 ) and tumor incidence as compared to DMBA/TPA-treated mice . D-Limonene treatment also extended the latency period of tumor development from 4 to 9 weeks . D-Limonene treatment decreased the expression level of Ras , Raf and phosphorylation of extracellular signal-regulated protein kinase 1/2 in DMBA/TPA-induced tumors . A decrease in the expression of Bcl-2 and an increase in Bax expression were also observed in tumor tissues of mice treated with D-limonene . Taken together , our findings suggest that D-limonene may exert its chemopreventive activity through the inhibition of inflammation , oxidative stress and Ras-signaling as well as the induction of pro-apoptotic state during TPA-mediated promotion of DMBA-induced skin cancer in mouse model .
    OUTPUT:
