human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Bladder cancer ( BCa ) remained a major health problem . Med19 was related to tumor growth of BCa . Bone morphogenetic proteins ( BMPs ) were reported to be critical in bone metastasis of cancer . We therefore investigated the relations between Med19 and BMPs in BCa and their effect on bone metastasis of BCa . Bladder cancer cell lines were cultured and interfered with Med19 shRNA and control . Expressions of BMP-1 , BMP-2 , BMP-4 , BMP-5 , BMP-6 , BMP-7 , BMP-9 , and BMP-15 were studied between 2 groups . Fifty-two BCa samples were included for immunohistochemical staining of Med19 and BMP-2 . Expressions were scored and studied statistically . Invasiveness was studied with Transwell assay . Silencing or Med19 in BCa cells induced altered expressions of BMPs . Increased expressions of BMP-1 , BMP-4 , BMP-6 , BMP-7 , and BMP-15 and decreased expressions of BMP-2 , BMP-5 , and BMP-9 were noticed , but only BMP-2 reached statistical significance . Expressions of Med19 and BMP-2 were significantly higher in cases with bone metastasis and were positively correlated in cases with bone metastasis and muscle invasion . Med19 is a critical factor involved in the invasiveness and promotion of bone metastasis of BCa , possibly via BMP-2 .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Bladder cancer ( BCa ) remained a major health problem . Med19 was related to tumor growth of BCa . Bone morphogenetic proteins ( BMPs ) were reported to be critical in bone metastasis of cancer . We therefore investigated the relations between Med19 and BMPs in BCa and their effect on bone metastasis of BCa . Bladder cancer cell lines were cultured and interfered with Med19 shRNA and control . Expressions of BMP-1 , BMP-2 , BMP-4 , BMP-5 , BMP-6 , BMP-7 , BMP-9 , and BMP-15 were studied between 2 groups . Fifty-two BCa samples were included for immunohistochemical staining of Med19 and BMP-2 . Expressions were scored and studied statistically . Invasiveness was studied with Transwell assay . Silencing or Med19 in BCa cells induced altered expressions of BMPs . Increased expressions of BMP-1 , BMP-4 , BMP-6 , BMP-7 , and BMP-15 and decreased expressions of BMP-2 , BMP-5 , and BMP-9 were noticed , but only BMP-2 reached statistical significance . Expressions of Med19 and BMP-2 were significantly higher in cases with bone metastasis and were positively correlated in cases with bone metastasis and muscle invasion . Med19 is a critical factor involved in the invasiveness and promotion of bone metastasis of BCa , possibly via BMP-2 .
    OUTPUT:
