human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Although the immunomodulatory effects of many herbs have been extensively studied , research related to possible immunomodulatory effects of various spices is relatively scarce . Here , the potential immunomodulatory effects of black pepper and cardamom are investigated . Our data show that black pepper and cardamom aqueous extracts significantly enhance splenocyte proliferation in a dose-dependent , synergistic fashion . Enzyme-linked immunosorbent assay experiments reveal that black pepper and cardamom significantly enhance and suppress , respectively , T helper ( Th)1 cytokine release by splenocytes . Conversely , Th2 cytokine release by splenocytes is significantly suppressed and enhanced by black pepper and cardamom , respectively . Experimental evidence suggests that black pepper and cardamom extracts exert pro-inflammatory and anti-inflammatory roles , respectively . Consistently , nitric oxide production by macrophages is significantly augmented and reduced by black pepper and cardamom , respectively . Remarkably , it is evident that black pepper and cardamom extracts significantly enhance the cytotoxic activity of natural killer cells , indicating their potential anti-cancer effects . Our findings strongly suggest that black pepper and cardamom exert immunomodulatory roles and antitumor activities , and hence they manifest themselves as natural agents that can promote the maintenance of a healthy immune system . We anticipate that black pepper and cardamom constituents can be used as potential therapeutic tools to regulate inflammatory responses and prevent/attenuate carcinogenesis .
    OUTPUT:

agent
tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Although the immunomodulatory effects of many herbs have been extensively studied , research related to possible immunomodulatory effects of various spices is relatively scarce . Here , the potential immunomodulatory effects of black pepper and cardamom are investigated . Our data show that black pepper and cardamom aqueous extracts significantly enhance splenocyte proliferation in a dose-dependent , synergistic fashion . Enzyme-linked immunosorbent assay experiments reveal that black pepper and cardamom significantly enhance and suppress , respectively , T helper ( Th)1 cytokine release by splenocytes . Conversely , Th2 cytokine release by splenocytes is significantly suppressed and enhanced by black pepper and cardamom , respectively . Experimental evidence suggests that black pepper and cardamom extracts exert pro-inflammatory and anti-inflammatory roles , respectively . Consistently , nitric oxide production by macrophages is significantly augmented and reduced by black pepper and cardamom , respectively . Remarkably , it is evident that black pepper and cardamom extracts significantly enhance the cytotoxic activity of natural killer cells , indicating their potential anti-cancer effects . Our findings strongly suggest that black pepper and cardamom exert immunomodulatory roles and antitumor activities , and hence they manifest themselves as natural agents that can promote the maintenance of a healthy immune system . We anticipate that black pepper and cardamom constituents can be used as potential therapeutic tools to regulate inflammatory responses and prevent/attenuate carcinogenesis .
    OUTPUT:
