human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The contribution of a type II restriction-modification system ( R-M system ) to genome integrity and cell viability was investigated . We established experimental conditions which enabled the achievement of hemimethylated and unmethylated states for the specific bases of the recognition sequences of the host's DNA . To achieve this , we constructed the MboII R-M system containing only one ( i.e . M2.MboII ) out of two functional MboII methyltransferases found in Moraxella bovis . Using the incomplete R-M system we were able to perturb the balance between methylation and restriction in an inducible manner . We demonstrate that upon the SOS-induced DNA repair in the mitomycin C treated cells , restriction significantly reduces cell viability . Similar results for the well-studied wild type EcoRI R-M system , expressed constitutively in Escherichia coli , were obtained . Our data provide further insights into the benefits and disadvantages of maintaining of a type II R-M system , highlighting its impact on host cell fitness .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The contribution of a type II restriction-modification system ( R-M system ) to genome integrity and cell viability was investigated . We established experimental conditions which enabled the achievement of hemimethylated and unmethylated states for the specific bases of the recognition sequences of the host's DNA . To achieve this , we constructed the MboII R-M system containing only one ( i.e . M2.MboII ) out of two functional MboII methyltransferases found in Moraxella bovis . Using the incomplete R-M system we were able to perturb the balance between methylation and restriction in an inducible manner . We demonstrate that upon the SOS-induced DNA repair in the mitomycin C treated cells , restriction significantly reduces cell viability . Similar results for the well-studied wild type EcoRI R-M system , expressed constitutively in Escherichia coli , were obtained . Our data provide further insights into the benefits and disadvantages of maintaining of a type II R-M system , highlighting its impact on host cell fitness .
    OUTPUT:
