human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: DNA double strand breaks ( DSBs ) arise from spontaneous DNA damage due to metabolic activities or from direct and indirect damaging effects of stress . DSBs are also formed transiently during such processes as replication , transcription , and DNA repair . The level of DSBs positively correlates with the activities of homologous and nonhomologous DNA repair pathways , which in turn inversely correlate with methylation levels and chromatin structure . Thus , measurement of strand breaks can provide an informative picture of genome stability of a given cell . The use of random oligonucleotide-primed synthesis for the analysis of DSB levels is described . Applications of the assay for quantitative detection of 3'OH , 3'P , or DNA strand breaks at a cleavage site of the deoxyribose residue are discussed .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: DNA double strand breaks ( DSBs ) arise from spontaneous DNA damage due to metabolic activities or from direct and indirect damaging effects of stress . DSBs are also formed transiently during such processes as replication , transcription , and DNA repair . The level of DSBs positively correlates with the activities of homologous and nonhomologous DNA repair pathways , which in turn inversely correlate with methylation levels and chromatin structure . Thus , measurement of strand breaks can provide an informative picture of genome stability of a given cell . The use of random oligonucleotide-primed synthesis for the analysis of DSB levels is described . Applications of the assay for quantitative detection of 3'OH , 3'P , or DNA strand breaks at a cleavage site of the deoxyribose residue are discussed .
    OUTPUT:
