human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Breast cancer is the second most common cancer with a high incidence rate worldwide . One of the promising therapeutic approaches on breast cancer is to use the drugs that target the estrogen receptor ( ER ) . In the present investigation , marmorin , a type I ribosome inactivating protein from the mushroom Hypsizigus marmoreus , inhibited the survival of breast cancer in vitro and in vivo . It evinced more potent cytotoxicity toward estrogen receptor ( ER)-positive MCF7 breast cancer cells than ER-negative MDA-MB-231 cells . Further study disclosed that marmorin undermined the expression level of estrogen receptor Î± ( ERÎ± ) and significantly inhibited the proliferation of MCF7 cells induced by 17Î²-estradiol . Knockdown of ERÎ± in MCF7 cells significantly attenuated the inhibitory effect of marmorin on proliferation , suggesting that the ERÎ±-mediated pathway was implicated in the suppressive action of marmorin on ER-positive breast cancer cells . Moreover , marmorin induced time-dependent apoptosis in both MCF7 and MDA-MB-231 cells . It brought about G2/M-phase arrest , mitochondrial membrane potential depolarization and caspase-9 activation in MCF7 cells , and to a lesser extent in MDA-MB-231 cells . Marmorin triggered the death receptor apoptotic pathway ( e.g. caspase-8 activation ) and endoplasmic reticulum stress ( ERS , as evidenced by phosphorylation of PERK and IRE1Î± , cleavage of caspase-12 , and up-regulation of CHOP expression ) in both MCF7 and MDA-MB-231 cells . In summary , marmorin exhibited inhibitory effect on breast cancer partially via diminution of ERÎ± and apoptotic pathways mediated by mitochondrial , death receptor and ERS . The results advocate that marmorin is a potential candidate for breast cancer therapy .
    OUTPUT:

agent
sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Breast cancer is the second most common cancer with a high incidence rate worldwide . One of the promising therapeutic approaches on breast cancer is to use the drugs that target the estrogen receptor ( ER ) . In the present investigation , marmorin , a type I ribosome inactivating protein from the mushroom Hypsizigus marmoreus , inhibited the survival of breast cancer in vitro and in vivo . It evinced more potent cytotoxicity toward estrogen receptor ( ER)-positive MCF7 breast cancer cells than ER-negative MDA-MB-231 cells . Further study disclosed that marmorin undermined the expression level of estrogen receptor Î± ( ERÎ± ) and significantly inhibited the proliferation of MCF7 cells induced by 17Î²-estradiol . Knockdown of ERÎ± in MCF7 cells significantly attenuated the inhibitory effect of marmorin on proliferation , suggesting that the ERÎ±-mediated pathway was implicated in the suppressive action of marmorin on ER-positive breast cancer cells . Moreover , marmorin induced time-dependent apoptosis in both MCF7 and MDA-MB-231 cells . It brought about G2/M-phase arrest , mitochondrial membrane potential depolarization and caspase-9 activation in MCF7 cells , and to a lesser extent in MDA-MB-231 cells . Marmorin triggered the death receptor apoptotic pathway ( e.g. caspase-8 activation ) and endoplasmic reticulum stress ( ERS , as evidenced by phosphorylation of PERK and IRE1Î± , cleavage of caspase-12 , and up-regulation of CHOP expression ) in both MCF7 and MDA-MB-231 cells . In summary , marmorin exhibited inhibitory effect on breast cancer partially via diminution of ERÎ± and apoptotic pathways mediated by mitochondrial , death receptor and ERS . The results advocate that marmorin is a potential candidate for breast cancer therapy .
    OUTPUT:
