human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Acute lymphoblastic leukemia is still an incurable disease with resistance to therapy developing in the majority of patients . We investigated the effect of TPEN , an intracellular zinc chelator , in Jurkat and in ex vivo acute lymphoblastic leukemia ( ALL ) cells resistant to chemotherapy . Changes of nuclei morphology , reactive oxygen species generation , presence of hypodiploid cells , phosphatidylserine translocation , mitochondrial membrane depolarization , immunohistochemical identification of cell death signalling molecules , and pharmacological inhibition were assayed to detect the apoptotic cell death pathways . We found that TPEN induces apoptosis in both types of cells by a molecular oxidative stress pathway involving O(2)(â¢-) &gt ; H(2)O(2) &gt ; NF-ÎºB ( JNK/c-Jun ) &gt;p53&gt ; loss ÎÎ¨(m)&gt ; caspase-3 , AIF &gt ; chromatin condensation/DNA fragmentation . Interestingly , TPEN induced apoptosis independently of glucose ; leukemic cells are therefore devoid of survival capacity by metabolic resistance to treatment . Most importantly , TPEN cytotoxic effect can eventually be regulated by the antioxidant N-acetyl-cysteine and zinc ions . Our data suggest that TPEN can be used as a potential therapeutic prooxidant agent against refractory leukemia . These data contribute to understanding the importance of oxidative stress in the treatment of ALL .
    OUTPUT:

agent
resisting cell death;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Acute lymphoblastic leukemia is still an incurable disease with resistance to therapy developing in the majority of patients . We investigated the effect of TPEN , an intracellular zinc chelator , in Jurkat and in ex vivo acute lymphoblastic leukemia ( ALL ) cells resistant to chemotherapy . Changes of nuclei morphology , reactive oxygen species generation , presence of hypodiploid cells , phosphatidylserine translocation , mitochondrial membrane depolarization , immunohistochemical identification of cell death signalling molecules , and pharmacological inhibition were assayed to detect the apoptotic cell death pathways . We found that TPEN induces apoptosis in both types of cells by a molecular oxidative stress pathway involving O(2)(â¢-) &gt ; H(2)O(2) &gt ; NF-ÎºB ( JNK/c-Jun ) &gt;p53&gt ; loss ÎÎ¨(m)&gt ; caspase-3 , AIF &gt ; chromatin condensation/DNA fragmentation . Interestingly , TPEN induced apoptosis independently of glucose ; leukemic cells are therefore devoid of survival capacity by metabolic resistance to treatment . Most importantly , TPEN cytotoxic effect can eventually be regulated by the antioxidant N-acetyl-cysteine and zinc ions . Our data suggest that TPEN can be used as a potential therapeutic prooxidant agent against refractory leukemia . These data contribute to understanding the importance of oxidative stress in the treatment of ALL .
    OUTPUT:
