human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Hepatocellular carcinoma ( HCC ) is one of the most common malignancies worldwide ; however , the prognosis of HCC patients remains poor . This poor prognosis is mainly attributed to the high rate of intrahepatic and distant metastasis . HCC often occurs in a hypoxic environment and hypoxia can activate metastatic programs , ultimately leading to tumor recurrence or metastasis . Thus , the discovery and subsequent development of novel agents to block HCC invasion and migration are the primary objectives of hepatic cancer research . The Notch1 signaling pathway might be involved in hypoxia-induced carcinoma metastasis . However , the mechanisms by which Notch1 mediates cell metastasis , particularly in hepatocellular carcinoma , are not yet entirely clear . The results of the present study show that hypoxia increases the invasion and migration capacities of different HCC cells . Activation of the Notch1 signaling pathway contributes to hypoxia-induced invasion and migration in HCC cells . The activated Notch1 signaling pathway can regulate Snail/E-cadherin through cyclooxygenase-2 ( COX-2 ) under hypoxic conditions . The above results suggest that the Notch1/COX-2/Snail/E-cadherin pathway is possibly associated with hypoxia-induced invasion and migration in HCC cells . Thus , targeting Notch1 may be useful for devising novel preventive and therapeutic strategies for HCC .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Hepatocellular carcinoma ( HCC ) is one of the most common malignancies worldwide ; however , the prognosis of HCC patients remains poor . This poor prognosis is mainly attributed to the high rate of intrahepatic and distant metastasis . HCC often occurs in a hypoxic environment and hypoxia can activate metastatic programs , ultimately leading to tumor recurrence or metastasis . Thus , the discovery and subsequent development of novel agents to block HCC invasion and migration are the primary objectives of hepatic cancer research . The Notch1 signaling pathway might be involved in hypoxia-induced carcinoma metastasis . However , the mechanisms by which Notch1 mediates cell metastasis , particularly in hepatocellular carcinoma , are not yet entirely clear . The results of the present study show that hypoxia increases the invasion and migration capacities of different HCC cells . Activation of the Notch1 signaling pathway contributes to hypoxia-induced invasion and migration in HCC cells . The activated Notch1 signaling pathway can regulate Snail/E-cadherin through cyclooxygenase-2 ( COX-2 ) under hypoxic conditions . The above results suggest that the Notch1/COX-2/Snail/E-cadherin pathway is possibly associated with hypoxia-induced invasion and migration in HCC cells . Thus , targeting Notch1 may be useful for devising novel preventive and therapeutic strategies for HCC .
    OUTPUT:
