human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Previously , we reported that Helicobacter pylori-associated gastritis and gastric cancer are closely associated with increased levels of hydrogen sulfide ( H2S ) and that Korean red ginseng significantly reduced the severity of H. pylori-associated gastric diseases by attenuating H2S generation . Because the incubation of endothelial cells with H2S has been known to enhance their angiogenic activities , we hypothesized that the amelioration of H2S-induced gastric inflammation or angiogenesis in human umbilical vascular endothelial cells ( HUVECs ) might explain the preventive effect of Korean red ginseng on H. pylori-associated carcinogenesis . The expression of inflammatory mediators , angiogenic growth factors , and angiogenic activities in the absence or presence of Korean red ginseng extracts ( KRGE ) were evaluated in HUVECs stimulated with the H2S generator sodium hydrogen sulfide ( NaHS ) . KRGE efficiently decreased the expression of cystathionine Î²-synthase and cystathionine Î³-lyase , enzymes that are essential for H2S synthesis . Concomitantly , a significant decrease in the expression of inflammatory mediators , including cyclooxygenase-2 and inducible nitric oxide synthase , and several angiogenic factors , including interleukin ( IL)-8 , hypoxia inducible factor-1a , vascular endothelial growth factor , IL-6 , and matrix metalloproteinases , was observed ; all of these factors are normally induced after NaHS . An in vitro angiogenesis assay demonstrated that NaHS significantly increased tube formation in endothelial cells , whereas KRGE pretreatment significantly attenuated tube formation . NaHS activated p38 and Akt , increasing the expression of angiogenic factors and the proliferation of HUVECs , whereas KRGE effectively abrogated this H2S-activated angiogenesis and the increase in inflammatory mediators in vascular endothelial cells . In conclusion , KRGE was able to mitigate H2S-induced angiogenesis , implying that antagonistic action against H2S-induced angiogenesis may be the mechanism underlying the gastric cancer preventive effects of KRGE in H. pylori infection .
    OUTPUT:

agent
inducing angiogenesis;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Previously , we reported that Helicobacter pylori-associated gastritis and gastric cancer are closely associated with increased levels of hydrogen sulfide ( H2S ) and that Korean red ginseng significantly reduced the severity of H. pylori-associated gastric diseases by attenuating H2S generation . Because the incubation of endothelial cells with H2S has been known to enhance their angiogenic activities , we hypothesized that the amelioration of H2S-induced gastric inflammation or angiogenesis in human umbilical vascular endothelial cells ( HUVECs ) might explain the preventive effect of Korean red ginseng on H. pylori-associated carcinogenesis . The expression of inflammatory mediators , angiogenic growth factors , and angiogenic activities in the absence or presence of Korean red ginseng extracts ( KRGE ) were evaluated in HUVECs stimulated with the H2S generator sodium hydrogen sulfide ( NaHS ) . KRGE efficiently decreased the expression of cystathionine Î²-synthase and cystathionine Î³-lyase , enzymes that are essential for H2S synthesis . Concomitantly , a significant decrease in the expression of inflammatory mediators , including cyclooxygenase-2 and inducible nitric oxide synthase , and several angiogenic factors , including interleukin ( IL)-8 , hypoxia inducible factor-1a , vascular endothelial growth factor , IL-6 , and matrix metalloproteinases , was observed ; all of these factors are normally induced after NaHS . An in vitro angiogenesis assay demonstrated that NaHS significantly increased tube formation in endothelial cells , whereas KRGE pretreatment significantly attenuated tube formation . NaHS activated p38 and Akt , increasing the expression of angiogenic factors and the proliferation of HUVECs , whereas KRGE effectively abrogated this H2S-activated angiogenesis and the increase in inflammatory mediators in vascular endothelial cells . In conclusion , KRGE was able to mitigate H2S-induced angiogenesis , implying that antagonistic action against H2S-induced angiogenesis may be the mechanism underlying the gastric cancer preventive effects of KRGE in H. pylori infection .
    OUTPUT:
