human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The NF-kB family of transcription factors regulates important biological functions including cell growth , survival and the immune response . We found that Human Papillomavirus type 16 ( HPV-16 ) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone , the anatomic region where most cervical cancers develop . In contrast , HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner . NF-kB influenced immortalization of cervical cells by HPV16 . Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16 . In contrast , activation of NF-kB by constitutive expression of p65 inhibited proliferation and immortalization . Our results suggest that inhibition of NF-kB by HPV-16 E6/E7 contributes to immortalization of cells from the cervical transformation zone .
    OUTPUT:

agent
enabling replicative immortality
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The NF-kB family of transcription factors regulates important biological functions including cell growth , survival and the immune response . We found that Human Papillomavirus type 16 ( HPV-16 ) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone , the anatomic region where most cervical cancers develop . In contrast , HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner . NF-kB influenced immortalization of cervical cells by HPV16 . Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16 . In contrast , activation of NF-kB by constitutive expression of p65 inhibited proliferation and immortalization . Our results suggest that inhibition of NF-kB by HPV-16 E6/E7 contributes to immortalization of cells from the cervical transformation zone .
    OUTPUT:
