human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Reprogramming of cellular metabolism is a key eventduring tumorigenesis . Despite being known for decades ( Warburg effect ) , the molecular mechanisms regulating this switch remained unexplored . Here , we identify SIRT6 as a tumor suppressor thatregulates aerobic glycolysis in cancer cells . Importantly , loss of SIRT6 leads to tumor formation without activation of known oncogenes , whereas transformed SIRT6-deficient cells display increased glycolysis and tumor growth , suggesting that SIRT6 plays a role in both establishment and maintenance of cancer . By using a conditional SIRT6 allele , we show that SIRT6 deletion invivo increases the number , size , and aggressiveness of tumors . SIRT6 also functions as a regulator of ribosome metabolismby corepressing MYC transcriptional activity . Lastly,Sirt6 is selectively downregulated in several human cancers , and expression levels of SIRT6 predict prognosis and tumor-free survival rates , highlighting SIRT6 as a critical modulator of cancermetabolism . Our studies reveal SIRT6 to be a potent tumor suppressor acting to suppress cancer metabolism .
    OUTPUT:

agent
cellular energetics;genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Reprogramming of cellular metabolism is a key eventduring tumorigenesis . Despite being known for decades ( Warburg effect ) , the molecular mechanisms regulating this switch remained unexplored . Here , we identify SIRT6 as a tumor suppressor thatregulates aerobic glycolysis in cancer cells . Importantly , loss of SIRT6 leads to tumor formation without activation of known oncogenes , whereas transformed SIRT6-deficient cells display increased glycolysis and tumor growth , suggesting that SIRT6 plays a role in both establishment and maintenance of cancer . By using a conditional SIRT6 allele , we show that SIRT6 deletion invivo increases the number , size , and aggressiveness of tumors . SIRT6 also functions as a regulator of ribosome metabolismby corepressing MYC transcriptional activity . Lastly,Sirt6 is selectively downregulated in several human cancers , and expression levels of SIRT6 predict prognosis and tumor-free survival rates , highlighting SIRT6 as a critical modulator of cancermetabolism . Our studies reveal SIRT6 to be a potent tumor suppressor acting to suppress cancer metabolism .
    OUTPUT:
