human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Cancers are characterized by an increasing glycolytic activity , which is called the Warburg effect . Although this phenomenon is well known , the mechanism of the enhanced rate of glycolysis in cancer has not yet been clearly recognized . The present study investigated the glycolytic rate , regulatory enzymatic activities and the expression of phosphofructokinase-1 ( PFK-1 ) in human breast cancer and paracancer tissues . Human breast cancer tissues have an increased degree of glycolytic efficiency and regulatory enzymatic activities , which have been shown in previous studies . However , the present study identified a number of novel observations . The total PFK-1 levels were higher in human breast cancer tissues than in paracancer tissues , and further investigations revealed differential PFK-1 isoenzyme expression patterns between human breast cancer and paracancer tissues . The human breast cancer and paracancer tissues mainly expressed PFK-P and PFK-L isoforms , respectively . Linear-regression analysis showed that , depending on the pathological stage of breast cancer , the expression of PFK-P was significantly positively correlated with the activity of PFK-1 . Thus , during the development of human breast cancer , the enhancement of glycolytic activity depends primarily on the conversion of the PFK-1 , from PFK-L to PFK-P .
    OUTPUT:

agent
cellular energetics
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Cancers are characterized by an increasing glycolytic activity , which is called the Warburg effect . Although this phenomenon is well known , the mechanism of the enhanced rate of glycolysis in cancer has not yet been clearly recognized . The present study investigated the glycolytic rate , regulatory enzymatic activities and the expression of phosphofructokinase-1 ( PFK-1 ) in human breast cancer and paracancer tissues . Human breast cancer tissues have an increased degree of glycolytic efficiency and regulatory enzymatic activities , which have been shown in previous studies . However , the present study identified a number of novel observations . The total PFK-1 levels were higher in human breast cancer tissues than in paracancer tissues , and further investigations revealed differential PFK-1 isoenzyme expression patterns between human breast cancer and paracancer tissues . The human breast cancer and paracancer tissues mainly expressed PFK-P and PFK-L isoforms , respectively . Linear-regression analysis showed that , depending on the pathological stage of breast cancer , the expression of PFK-P was significantly positively correlated with the activity of PFK-1 . Thus , during the development of human breast cancer , the enhancement of glycolytic activity depends primarily on the conversion of the PFK-1 , from PFK-L to PFK-P .
    OUTPUT:
