human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Despite the deployment of multimodal therapies involving neurosurgical resection , radio- and polychemotherapy , the prognosis for glioblastoma patients remains poor . These tumors are pathologically characterized by their associated angiogenesis and diffuse brain invasion , processes that are probably closely linked to the unfavorable prognosis of this disease . Accordingly , pharmacological inhibition of glioblastoma invasion and approaches that impede angiogenesis are considered to be promising therapeutic strategies to combat these tumors . Nevertheless , the anti-angiogenic therapies for glioblastoma currently available are transient and palliative at best . Blocking the effects of fibroblast growth factor ( FGF ) may represent a novel mean of inhibiting the angiogenesis associated with glioblastoma , as it mediates the angiogenesis induced by other factors and it is an angiogenic factor by itself . In addition , the survival of glioma cells and their resistance to chemotherapeutic agents are highly FGF-dependent . We show here that a recently described inhibitor of FGF , 2,5-dihydroxyphenyl-sulfonate ( 2,5DHPS , dobesilate ) , stimulates the apoptosis of tumor cells , inhibits glioblastoma invasion and suppresses its associated angiogenesis . Moreover , this agent augments the efficiency of chemotherapeutic agents in a rat model of orthotopic brain tumor . These results suggest that 2,5DHPS treatment may represent a promising therapy for malignant glioma .
    OUTPUT:

agent
inducing angiogenesis;sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Despite the deployment of multimodal therapies involving neurosurgical resection , radio- and polychemotherapy , the prognosis for glioblastoma patients remains poor . These tumors are pathologically characterized by their associated angiogenesis and diffuse brain invasion , processes that are probably closely linked to the unfavorable prognosis of this disease . Accordingly , pharmacological inhibition of glioblastoma invasion and approaches that impede angiogenesis are considered to be promising therapeutic strategies to combat these tumors . Nevertheless , the anti-angiogenic therapies for glioblastoma currently available are transient and palliative at best . Blocking the effects of fibroblast growth factor ( FGF ) may represent a novel mean of inhibiting the angiogenesis associated with glioblastoma , as it mediates the angiogenesis induced by other factors and it is an angiogenic factor by itself . In addition , the survival of glioma cells and their resistance to chemotherapeutic agents are highly FGF-dependent . We show here that a recently described inhibitor of FGF , 2,5-dihydroxyphenyl-sulfonate ( 2,5DHPS , dobesilate ) , stimulates the apoptosis of tumor cells , inhibits glioblastoma invasion and suppresses its associated angiogenesis . Moreover , this agent augments the efficiency of chemotherapeutic agents in a rat model of orthotopic brain tumor . These results suggest that 2,5DHPS treatment may represent a promising therapy for malignant glioma .
    OUTPUT:
