human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Angiogenesis is the process of new blood vessel formation from pre-existing ones . Angiogenic factors contribute to neovascularization that takes place in angiogenesis-dependent diseases , including cancer . Inhibiting the activity of the angiogenic factors to block the angiogenesis pathways is the current strategy of cancer therapy . Basic fibroblast growth factor ( bFGF ) is regarded as one of the most important angiogenic factors . Herein , we selected polyoxometalates ( POMs ) with different structures to study the interactions between bFGF and POMs . The results show that POMs could bind to the protein with high affinity , causing detectable changes in conformation and biophysical properties of protein . In addition , POMs could effectively inhibit the cell proliferation induced by bFGF . Significantly , we found that the structure , size and composition of POMs play a key role in the interactions between bFGF and POMs . This study will be meaningful for future screening and design of polyoxometalate-based anticancer drugs .
    OUTPUT:

agent
inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Angiogenesis is the process of new blood vessel formation from pre-existing ones . Angiogenic factors contribute to neovascularization that takes place in angiogenesis-dependent diseases , including cancer . Inhibiting the activity of the angiogenic factors to block the angiogenesis pathways is the current strategy of cancer therapy . Basic fibroblast growth factor ( bFGF ) is regarded as one of the most important angiogenic factors . Herein , we selected polyoxometalates ( POMs ) with different structures to study the interactions between bFGF and POMs . The results show that POMs could bind to the protein with high affinity , causing detectable changes in conformation and biophysical properties of protein . In addition , POMs could effectively inhibit the cell proliferation induced by bFGF . Significantly , we found that the structure , size and composition of POMs play a key role in the interactions between bFGF and POMs . This study will be meaningful for future screening and design of polyoxometalate-based anticancer drugs .
    OUTPUT:
