human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Luteolin is a plant flavonoid which exhibits anti-oxidative , anti-inflammatory and anti-tumor effects . However , the antiproliferative potential of luteolin is not fully understood . In this study , we investigated the effect of luteolin on cell cycling and apoptosis in human esophageal squamous carcinoma cell line Eca109 cells . MTT assays showed that luteolin had obvious cytotoxicity on Eca109 with an IC50 of 70.7ï¿½1.72 Î¼M at 24 h . Luteolin arrested cell cycle progression in the G0/G1 phase and prevented entry into S phase in a dose- and time-dependent manner. as assessed by FCM . Luteolin induced apoptosis of Eca109 cells was demonstrated by AO/EB staining assay and annexin V-FITC/PI staining . Moreover , luteolin downregulated the expression of cyclin D1 , survivin and c-myc , and it also upregulated the expression of p53 , in line with the fact that luteolin was able to inhibit Eca109 cell proliferation .
    OUTPUT:

agent
sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Luteolin is a plant flavonoid which exhibits anti-oxidative , anti-inflammatory and anti-tumor effects . However , the antiproliferative potential of luteolin is not fully understood . In this study , we investigated the effect of luteolin on cell cycling and apoptosis in human esophageal squamous carcinoma cell line Eca109 cells . MTT assays showed that luteolin had obvious cytotoxicity on Eca109 with an IC50 of 70.7ï¿½1.72 Î¼M at 24 h . Luteolin arrested cell cycle progression in the G0/G1 phase and prevented entry into S phase in a dose- and time-dependent manner. as assessed by FCM . Luteolin induced apoptosis of Eca109 cells was demonstrated by AO/EB staining assay and annexin V-FITC/PI staining . Moreover , luteolin downregulated the expression of cyclin D1 , survivin and c-myc , and it also upregulated the expression of p53 , in line with the fact that luteolin was able to inhibit Eca109 cell proliferation .
    OUTPUT:
