human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Multivitamin preparation ( MVP ) is part of total parenteral nutrition given to premature infants . Photoactivated MVP carries an important load in peroxides , but their cellular effects have not yet been determined . We hypothesized that these peroxides may elicit a DNA-damage response . We found that photoactivation of MVP and the resulting peroxide production were time-dependent and required the simultaneous presence of ascorbic acid and riboflavin . Cells treated with photoactivated MVP showed strongly stimulated poly(ADP-ribosyl)ation , an early DNA-damage response in mammals . Poly(ADP-ribosyl)ation stimulation was dependent on the presence of ascorbic acid and riboflavin in the photoactivated MVP . It did not occur in the presence of a specific PARP inhibitor nor in mouse fibroblasts deficient in PARP-1 . Photoactivated MVP was able to induce single- and double-strand breaks in DNA , with a predominance of single-stand breaks . The presence of double-strand breaks was further confirmed using a 53PB1 focus analysis . Finally , photoactivated MVP was shown to be toxic to human cells and induced caspase-independent cell death . These results suggest that photoactivated MVP carries an important toxic load able to damage DNA and induce cell death . This study also emphasizes the importance of protecting MVP solution from light before use in preterm infants .
    OUTPUT:

agent
genomic instability and mutation;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Multivitamin preparation ( MVP ) is part of total parenteral nutrition given to premature infants . Photoactivated MVP carries an important load in peroxides , but their cellular effects have not yet been determined . We hypothesized that these peroxides may elicit a DNA-damage response . We found that photoactivation of MVP and the resulting peroxide production were time-dependent and required the simultaneous presence of ascorbic acid and riboflavin . Cells treated with photoactivated MVP showed strongly stimulated poly(ADP-ribosyl)ation , an early DNA-damage response in mammals . Poly(ADP-ribosyl)ation stimulation was dependent on the presence of ascorbic acid and riboflavin in the photoactivated MVP . It did not occur in the presence of a specific PARP inhibitor nor in mouse fibroblasts deficient in PARP-1 . Photoactivated MVP was able to induce single- and double-strand breaks in DNA , with a predominance of single-stand breaks . The presence of double-strand breaks was further confirmed using a 53PB1 focus analysis . Finally , photoactivated MVP was shown to be toxic to human cells and induced caspase-independent cell death . These results suggest that photoactivated MVP carries an important toxic load able to damage DNA and induce cell death . This study also emphasizes the importance of protecting MVP solution from light before use in preterm infants .
    OUTPUT:
