human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide ( H2O2 ) in murine Hepa-1c1c7 cells . Oxidative DNA damage was estimated by nuclear condensation assessment , fluorescence-activated cell sorting analysis , and Comet assay . Rutaecarpine inhibited cell death induced by 500 μM H2O2 , as assessed by 4',6-diamidino-2-phenylindole ( DAPI ) staining . Treatment with rutaecarpine reduced the number of DNA strand breaks induced by H2O2 , as assessed by DAPI staining and Comet assay , and increased quinone reductase , phosphatidylinositol 3-kinase , and pAkt protein levels , as assessed by western blotting .
    OUTPUT:

agent
resisting cell death;genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide ( H2O2 ) in murine Hepa-1c1c7 cells . Oxidative DNA damage was estimated by nuclear condensation assessment , fluorescence-activated cell sorting analysis , and Comet assay . Rutaecarpine inhibited cell death induced by 500 μM H2O2 , as assessed by 4',6-diamidino-2-phenylindole ( DAPI ) staining . Treatment with rutaecarpine reduced the number of DNA strand breaks induced by H2O2 , as assessed by DAPI staining and Comet assay , and increased quinone reductase , phosphatidylinositol 3-kinase , and pAkt protein levels , as assessed by western blotting .
    OUTPUT:
