human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Photodynamic therapy ( PDT ) of hepatic tumours has been restricted owing to the preferential retention of photosensitizers in liver tissue . We therefore investigated interstitial tumour illumination as a means of selective PDT . A piece of colon carcinoma CC531 was implanted in the liver of Wag/Rij rats . Photofrin was administered ( 5 mg kg-1 i.v. ) 2 days before laser illumination . Tumours with a mean ( +/- s.e. ) diameter of 5.7 +/- 0.1 mm ( n = 106 , 20 days after implantation ) were illuminated with 625 nm light , at 200 mW cm-1 from a 0.5 cm cylindrical diffuser and either 100 , 200 , 400 , 800 or 1600 J cm-1 . Control groups received either laser illumination only , Photofrin only or diffuser insertion only . Short-term effects were studied on the second day after illumination by light microscopy and computer-assisted integration of the circumference of damaged areas . Long-term effects were studied on day 36 . To determine the biochemistry of liver damage and function , serum ASAT and ALAT levels were measured on day 1 and 2 , and antipyrine clearance on day 1 . Tumour and surrounding liver necrosis increased with light dose delivered ( P &lt ; 0.001 ) . Best long-term results were obtained at 800 J cm-1 with complete tumour remission in 4 out of 6 animals . No deterioration in liver function was found . The results of this study show the ability of interstitial PDT to cause major destruction of tumour tissue in the liver combined with minimal liver damage .
    OUTPUT:

agent
resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Photodynamic therapy ( PDT ) of hepatic tumours has been restricted owing to the preferential retention of photosensitizers in liver tissue . We therefore investigated interstitial tumour illumination as a means of selective PDT . A piece of colon carcinoma CC531 was implanted in the liver of Wag/Rij rats . Photofrin was administered ( 5 mg kg-1 i.v. ) 2 days before laser illumination . Tumours with a mean ( +/- s.e. ) diameter of 5.7 +/- 0.1 mm ( n = 106 , 20 days after implantation ) were illuminated with 625 nm light , at 200 mW cm-1 from a 0.5 cm cylindrical diffuser and either 100 , 200 , 400 , 800 or 1600 J cm-1 . Control groups received either laser illumination only , Photofrin only or diffuser insertion only . Short-term effects were studied on the second day after illumination by light microscopy and computer-assisted integration of the circumference of damaged areas . Long-term effects were studied on day 36 . To determine the biochemistry of liver damage and function , serum ASAT and ALAT levels were measured on day 1 and 2 , and antipyrine clearance on day 1 . Tumour and surrounding liver necrosis increased with light dose delivered ( P &lt ; 0.001 ) . Best long-term results were obtained at 800 J cm-1 with complete tumour remission in 4 out of 6 animals . No deterioration in liver function was found . The results of this study show the ability of interstitial PDT to cause major destruction of tumour tissue in the liver combined with minimal liver damage .
    OUTPUT:
