human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE The aim of this retrospective study is to analyze the clinical and pathological factors related to the prognosis of Chinese patients with stage Ib to IIb cervical cancer . METHODS AND RESULTS 13 clinical pathological factors in 255 patients with stage Ib to IIb cervical cancer undergoing radical hysterectomy and systematic lymphadenectomy were analyzed to screen for factors related to prognosis . The cumulative 5-year survival of the 255 patients was 75.7% . The result of the univariate analysis suggested that clinical stage , cell differentiation , depth of cervical stromal invasion , parametrial tissue involvement , and lymph node metastasis were prognostic factors for patients with stage Ib to IIb cervical cancer ( P&lt;0.05 ) . Compared with cases with involvement of iliac nodes , obturator nodes , or inguinal lymph nodes , cases with metastasis to the common iliac lymph nodes had a poorer prognosis ( P&lt;0.05 ) . Cases with involvement of four or more lymph nodes had a poorer prognosis than those with involvement of three or fewer lymph nodes ( P&lt;0.05 ) . Using multivariate Cox proportional hazards model regression analysis , non-squamous histological type , poor differentiation , parametrial tissue involvement , and outer 1/3 stromal invasion were found to be independently related to patients poor prognosis ( P&lt;0.05 ) . CONCLUSION Non-squamous histological type , poor cell differentiation , parametrial tissue involvement , and outer 1/3 stromal invasion are the independent poor prognostic factors for patients with stage Ib to IIb cervical cancer .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE The aim of this retrospective study is to analyze the clinical and pathological factors related to the prognosis of Chinese patients with stage Ib to IIb cervical cancer . METHODS AND RESULTS 13 clinical pathological factors in 255 patients with stage Ib to IIb cervical cancer undergoing radical hysterectomy and systematic lymphadenectomy were analyzed to screen for factors related to prognosis . The cumulative 5-year survival of the 255 patients was 75.7% . The result of the univariate analysis suggested that clinical stage , cell differentiation , depth of cervical stromal invasion , parametrial tissue involvement , and lymph node metastasis were prognostic factors for patients with stage Ib to IIb cervical cancer ( P&lt;0.05 ) . Compared with cases with involvement of iliac nodes , obturator nodes , or inguinal lymph nodes , cases with metastasis to the common iliac lymph nodes had a poorer prognosis ( P&lt;0.05 ) . Cases with involvement of four or more lymph nodes had a poorer prognosis than those with involvement of three or fewer lymph nodes ( P&lt;0.05 ) . Using multivariate Cox proportional hazards model regression analysis , non-squamous histological type , poor differentiation , parametrial tissue involvement , and outer 1/3 stromal invasion were found to be independently related to patients poor prognosis ( P&lt;0.05 ) . CONCLUSION Non-squamous histological type , poor cell differentiation , parametrial tissue involvement , and outer 1/3 stromal invasion are the independent poor prognostic factors for patients with stage Ib to IIb cervical cancer .
    OUTPUT:
