human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: A metaphase chromosome analysis method was used to evaluate the mutagenic activity of volatile petroleum fractions in chronically intoxicated rats . The findings indicate that chronic inhalation exposure of the rats to volatile petroleum fractions at different concentrations results in a significant ( 2.5-fold ) increase , compared to the spontaneous level , in the occurrence of chromosomal aberrations in the bone marrow cells in a number of generations . In addition to chromosomal structural abnormalities , there are genomic changes ( aneuploidy , polyploidy ) . There is a tendency towards an increased rate of petroleum-induced chromosomal aberrations in a number of generations ( P , F1 , and F2 ) in the rat bone marrow cells . The maximum mutagenic effect of volatile petroleum fractions was found when used at concentrations of 10 and 100 mg/l upon long-term chronic exposure during three generations ( P1 , F1 , and F2 ) . The findings are indicative of the mutagenic activity of volatile petroleum fractions , which is likely to pose a potential risk from environmental pollution to biota and population health in the area of intensive oil extraction and refining .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: A metaphase chromosome analysis method was used to evaluate the mutagenic activity of volatile petroleum fractions in chronically intoxicated rats . The findings indicate that chronic inhalation exposure of the rats to volatile petroleum fractions at different concentrations results in a significant ( 2.5-fold ) increase , compared to the spontaneous level , in the occurrence of chromosomal aberrations in the bone marrow cells in a number of generations . In addition to chromosomal structural abnormalities , there are genomic changes ( aneuploidy , polyploidy ) . There is a tendency towards an increased rate of petroleum-induced chromosomal aberrations in a number of generations ( P , F1 , and F2 ) in the rat bone marrow cells . The maximum mutagenic effect of volatile petroleum fractions was found when used at concentrations of 10 and 100 mg/l upon long-term chronic exposure during three generations ( P1 , F1 , and F2 ) . The findings are indicative of the mutagenic activity of volatile petroleum fractions , which is likely to pose a potential risk from environmental pollution to biota and population health in the area of intensive oil extraction and refining .
    OUTPUT:
