human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: In our study we investigated the level of apoptosis in PBMCs and the serological level of sFas ( CD95/APO-1 ) in 22 patients with malignant melanoma ( 12 patients with unique cutaneous primary tumour and 10 patients with unique brain metastasis ) . The first determination was performed before tumour excision and the second at 6-7 months after excision . Results in patients with primary tumour in the first determination : 6 patients with over normal values in PBMCs apoptosis and 5 patients with increased values of sFas . In the second determination : apoptosis was increased in 5 patients and sFas level was increased in 4 cases . In patients with metastases in the first determination apoptosis of PBMC was increased in 7 cases and sFas in 5 cases . In the second determination apoptosis was increased in 4 cases and sFas was increased in 4 cases . Our results show that half of the investigated patients presented elevated values of PBMCs apoptosis and Fas receptor both before and 6-7 months after tumour excision . Apoptosis values for PBMCs and sFas values were with 1/4 higher than normals . There was no difference in clinical evolution of the patients with normal or increased values for studied parameters . Clinical evolution was performed for 1 year . The presence of increased values for PBMCs and sFas after tumour excision , primary or metastasis is surprising and hard to explain . It is possible that tumoral evolution induces a disregulation at PBMCs level or other cells level that persists unexpectedly , after tumour excision or apoptotic processes , in a certain level to be independent and anterior to tumour development .
    OUTPUT:

agent
resisting cell death;activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: In our study we investigated the level of apoptosis in PBMCs and the serological level of sFas ( CD95/APO-1 ) in 22 patients with malignant melanoma ( 12 patients with unique cutaneous primary tumour and 10 patients with unique brain metastasis ) . The first determination was performed before tumour excision and the second at 6-7 months after excision . Results in patients with primary tumour in the first determination : 6 patients with over normal values in PBMCs apoptosis and 5 patients with increased values of sFas . In the second determination : apoptosis was increased in 5 patients and sFas level was increased in 4 cases . In patients with metastases in the first determination apoptosis of PBMC was increased in 7 cases and sFas in 5 cases . In the second determination apoptosis was increased in 4 cases and sFas was increased in 4 cases . Our results show that half of the investigated patients presented elevated values of PBMCs apoptosis and Fas receptor both before and 6-7 months after tumour excision . Apoptosis values for PBMCs and sFas values were with 1/4 higher than normals . There was no difference in clinical evolution of the patients with normal or increased values for studied parameters . Clinical evolution was performed for 1 year . The presence of increased values for PBMCs and sFas after tumour excision , primary or metastasis is surprising and hard to explain . It is possible that tumoral evolution induces a disregulation at PBMCs level or other cells level that persists unexpectedly , after tumour excision or apoptotic processes , in a certain level to be independent and anterior to tumour development .
    OUTPUT:
