human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The signal transducer and activator of transcription ( STAT)1 is a cytoplasmic-transcription factor that is phosphorylated by Janus kinases ( Jak ) in response to interferon gamma(IFN-gamma) . The phosphorylated STAT1 translocates to the nucleus , where it turns on specific sets of IFN-gamma-inducible genes , such as the interferon regulatory factor ( IRF)-1 . We show here that gamma irradiation reduces the IFN-gamma mRNA expression . The inhibition of the STAT1 phosphorylation and the IRF-1 expression by gamma irradiation was also observed . In contrast , the mRNA levels of IL-5 and transcription factor GATA-3 were slightly induced by gamma irradiation when compared to the non-irradiated sample . Furthermore , we detected the inhibition of cell-mediated immunity by gamma irradiation in the allogenic-mixed lymphocytes ' reaction ( MLR ) . These results postulate that gamma irradiation induces the polarized-Th2 response and interferes with STAT1 signals , thereby causing the immunosuppression of the Th1 response .
    OUTPUT:

agent
avoiding immune destruction
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The signal transducer and activator of transcription ( STAT)1 is a cytoplasmic-transcription factor that is phosphorylated by Janus kinases ( Jak ) in response to interferon gamma(IFN-gamma) . The phosphorylated STAT1 translocates to the nucleus , where it turns on specific sets of IFN-gamma-inducible genes , such as the interferon regulatory factor ( IRF)-1 . We show here that gamma irradiation reduces the IFN-gamma mRNA expression . The inhibition of the STAT1 phosphorylation and the IRF-1 expression by gamma irradiation was also observed . In contrast , the mRNA levels of IL-5 and transcription factor GATA-3 were slightly induced by gamma irradiation when compared to the non-irradiated sample . Furthermore , we detected the inhibition of cell-mediated immunity by gamma irradiation in the allogenic-mixed lymphocytes ' reaction ( MLR ) . These results postulate that gamma irradiation induces the polarized-Th2 response and interferes with STAT1 signals , thereby causing the immunosuppression of the Th1 response .
    OUTPUT:
