human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Vitamin D deficiency is associated with the high risk of colon cancer and a variety of other diseases . The active vitamin D metabolite 1Î±,25-dihydroxyvitamin D(3) ( 1,25(OH)(2)D(3) ) regulates gene transcription via its nuclear receptor ( VDR ) , and posttranscriptional regulatory mechanisms of gene expression have also been proposed . We have identified microRNA-22 ( miR-22 ) and several other miRNA species as 1,25(OH)(2)D(3) targets in human colon cancer cells . Remarkably , miR-22 is induced by 1,25(OH)(2)D(3) in a time- , dose- and VDR-dependent manner . In SW480-ADH and HCT116 cells , miR-22 loss-of-function by transfection of a miR-22 inhibitor suppresses the antiproliferative effect of 1,25(OH)(2)D(3) . Additionally , miR-22 inhibition increases cell migration per se and decreases the antimigratory effect of 1,25(OH)(2)D(3) in both cell types . In silico analysis shows a significant overlap between genes suppressed by 1,25(OH)(2)D(3) and miR-22 putative target genes . Consistently , miR-22 inhibition abrogates the 1,25(OH)(2)D(3)-mediated suppression of NELL2 , OGN , HNRPH1 , RERE and NFAT5 genes . In 39 out of 50 ( 78% ) human colon cancer patients , miR-22 expression was found lower in the tumour than in the matched normal tissue and correlated directly with that of VDR . Our results indicate that miR-22 is induced by 1,25(OH)(2)D(3) in human colon cancer cells and it may contribute to its antitumour action against this neoplasia .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Vitamin D deficiency is associated with the high risk of colon cancer and a variety of other diseases . The active vitamin D metabolite 1Î±,25-dihydroxyvitamin D(3) ( 1,25(OH)(2)D(3) ) regulates gene transcription via its nuclear receptor ( VDR ) , and posttranscriptional regulatory mechanisms of gene expression have also been proposed . We have identified microRNA-22 ( miR-22 ) and several other miRNA species as 1,25(OH)(2)D(3) targets in human colon cancer cells . Remarkably , miR-22 is induced by 1,25(OH)(2)D(3) in a time- , dose- and VDR-dependent manner . In SW480-ADH and HCT116 cells , miR-22 loss-of-function by transfection of a miR-22 inhibitor suppresses the antiproliferative effect of 1,25(OH)(2)D(3) . Additionally , miR-22 inhibition increases cell migration per se and decreases the antimigratory effect of 1,25(OH)(2)D(3) in both cell types . In silico analysis shows a significant overlap between genes suppressed by 1,25(OH)(2)D(3) and miR-22 putative target genes . Consistently , miR-22 inhibition abrogates the 1,25(OH)(2)D(3)-mediated suppression of NELL2 , OGN , HNRPH1 , RERE and NFAT5 genes . In 39 out of 50 ( 78% ) human colon cancer patients , miR-22 expression was found lower in the tumour than in the matched normal tissue and correlated directly with that of VDR . Our results indicate that miR-22 is induced by 1,25(OH)(2)D(3) in human colon cancer cells and it may contribute to its antitumour action against this neoplasia .
    OUTPUT:
