human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: SCOPE In this study , we evaluated the efficacy of lycopene against the growth of prostate cancer in vivo . METHODS AND RESULTS Athymic nude mice were implanted subcutaneously with human androgen-independent prostate carcinoma PC-3 cells . They were supplemented with a low or a high dose of lycopene ( 4 and 16âmg/kg ) and a single dose of Î²-carotene ( 16âmg/kg ) twice a week for 7 wk . At the end of the experiment , both lycopene and Î²-carotene strongly inhibited the tumor growth , as evidenced by the decrease in tumor volume and tumor weight . High-dosage lycopene and Î²-carotene significantly decreased the expression of proliferating cell nuclear antigen in tumor tissues and increased the levels of insulin-like growth factor-binding protein-3 in plasma . In addition , high-dosage lycopene supplementation significantly decreased the vascular endothelial growth factor ( VEGF ) levels in plasma . In contrast , Î²-carotene supplementation significantly increased the VEGF levels , as compared with tumor control group . CONCLUSION Lycopene and Î²-carotene supplementation suppressed the growth of prostate tumor cells , and the effects are likely associated with reduction of proliferation ( attenuation of proliferating cell nuclear antigen expression ) and with interference of the insulin-like growth factor 1 signaling ( increased plasma insulin-like growth factor-binding protein-3 levels ) . Furthermore , the inhibition of VEGF by lycopene suggests that the antitumor mechanisms of lycopene also involve anti-angiogenesis .
    OUTPUT:

agent
sustaining proliferative signaling;inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: SCOPE In this study , we evaluated the efficacy of lycopene against the growth of prostate cancer in vivo . METHODS AND RESULTS Athymic nude mice were implanted subcutaneously with human androgen-independent prostate carcinoma PC-3 cells . They were supplemented with a low or a high dose of lycopene ( 4 and 16âmg/kg ) and a single dose of Î²-carotene ( 16âmg/kg ) twice a week for 7 wk . At the end of the experiment , both lycopene and Î²-carotene strongly inhibited the tumor growth , as evidenced by the decrease in tumor volume and tumor weight . High-dosage lycopene and Î²-carotene significantly decreased the expression of proliferating cell nuclear antigen in tumor tissues and increased the levels of insulin-like growth factor-binding protein-3 in plasma . In addition , high-dosage lycopene supplementation significantly decreased the vascular endothelial growth factor ( VEGF ) levels in plasma . In contrast , Î²-carotene supplementation significantly increased the VEGF levels , as compared with tumor control group . CONCLUSION Lycopene and Î²-carotene supplementation suppressed the growth of prostate tumor cells , and the effects are likely associated with reduction of proliferation ( attenuation of proliferating cell nuclear antigen expression ) and with interference of the insulin-like growth factor 1 signaling ( increased plasma insulin-like growth factor-binding protein-3 levels ) . Furthermore , the inhibition of VEGF by lycopene suggests that the antitumor mechanisms of lycopene also involve anti-angiogenesis .
    OUTPUT:
