human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Recently , our group reported the discovery of three new withanolides , physangulidines A-C , from Physalis angulata . In this study , the biological effects of physangulidine A ( 1 ) , which was the most active and abundant of the three new constituents , are described . It was found that 1 significantly reduces survival in clonogenic assays for two hormone-independent prostate cancer cell lines . Flow cytometry and confocal microscopy studies in DU145 human prostate cancer cells indicated that 1 induces cell cycle arrest in the G(2)/M phase and causes defective mitosis . It was determined also that 1 produces programed cell death by apoptosis , as evidenced by biochemical markers and distinct changes in cell morphology . These results imply that the antimitotic and proapoptotic effects of 1 may contribute significantly to the biological activities and potential medicinal properties of its plant of origin .
    OUTPUT:

agent
evading growth suppressors;sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Recently , our group reported the discovery of three new withanolides , physangulidines A-C , from Physalis angulata . In this study , the biological effects of physangulidine A ( 1 ) , which was the most active and abundant of the three new constituents , are described . It was found that 1 significantly reduces survival in clonogenic assays for two hormone-independent prostate cancer cell lines . Flow cytometry and confocal microscopy studies in DU145 human prostate cancer cells indicated that 1 induces cell cycle arrest in the G(2)/M phase and causes defective mitosis . It was determined also that 1 produces programed cell death by apoptosis , as evidenced by biochemical markers and distinct changes in cell morphology . These results imply that the antimitotic and proapoptotic effects of 1 may contribute significantly to the biological activities and potential medicinal properties of its plant of origin .
    OUTPUT:
