human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Von Hippel-Lindau ( VHL ) is a tumor suppressor that negatively regulates the production of angiogenic factors . Mutations in the VHL gene cause VHL syndrome , which is characterized by highly vascularized tumors . Here we report a c.464T&gt;A mutation of the VHL gene in three patients with hemangioblastoma from a Chinese family . This mutation was not reported previously and was absent in the unaffected family members . The mutation is predicted to cause Val to Glu substitution at VHL protein residue 155 in a conserved region . Previous biochemical studies demonstrated that residue Val-155 was critical for VHL protein binding to chaperonin TRiC/CCT , an essential step for proper VHL protein folding . Our finding of naturally occurring VHL V155E mutation in patients with VHL syndrome supports the functional importance of Val-155 residue in VHL protein and illustrates the diversity of VHL gene defects underlying VHL syndrome .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Von Hippel-Lindau ( VHL ) is a tumor suppressor that negatively regulates the production of angiogenic factors . Mutations in the VHL gene cause VHL syndrome , which is characterized by highly vascularized tumors . Here we report a c.464T&gt;A mutation of the VHL gene in three patients with hemangioblastoma from a Chinese family . This mutation was not reported previously and was absent in the unaffected family members . The mutation is predicted to cause Val to Glu substitution at VHL protein residue 155 in a conserved region . Previous biochemical studies demonstrated that residue Val-155 was critical for VHL protein binding to chaperonin TRiC/CCT , an essential step for proper VHL protein folding . Our finding of naturally occurring VHL V155E mutation in patients with VHL syndrome supports the functional importance of Val-155 residue in VHL protein and illustrates the diversity of VHL gene defects underlying VHL syndrome .
    OUTPUT:
