human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: We report a case of recurrent gastric cancer successfully treated by a combination of CPT-11 and CDDP as the third- line chemotherapy . A 78-year-old man with advanced gastric cancer underwent a curative distal gastrectomy . Three years later , the tumor marker level began to rise and computed tomography ( CT ) revealed lymph node metastasis invading the pancreas resulting in pancreatic duct dilatation . S-1 treatment was initiated but was discontinued because of a systemic exanthem . Paclitaxel was administrated as secondary chemotherapy . But , after 2 courses , a further increase in the tumor marker level and portal vein invasion were observed . Combination therapy of CPT-11 and CDDP was administered as the third-line chemotherapy . After 3 courses , the tumor marker level normalized , tumor size decreased , and the invasion was eliminated . Third-line chemotherapy against recurrent gastric cancer should be considered if patient performance status ( PS ) is maintained .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: We report a case of recurrent gastric cancer successfully treated by a combination of CPT-11 and CDDP as the third- line chemotherapy . A 78-year-old man with advanced gastric cancer underwent a curative distal gastrectomy . Three years later , the tumor marker level began to rise and computed tomography ( CT ) revealed lymph node metastasis invading the pancreas resulting in pancreatic duct dilatation . S-1 treatment was initiated but was discontinued because of a systemic exanthem . Paclitaxel was administrated as secondary chemotherapy . But , after 2 courses , a further increase in the tumor marker level and portal vein invasion were observed . Combination therapy of CPT-11 and CDDP was administered as the third-line chemotherapy . After 3 courses , the tumor marker level normalized , tumor size decreased , and the invasion was eliminated . Third-line chemotherapy against recurrent gastric cancer should be considered if patient performance status ( PS ) is maintained .
    OUTPUT:
