human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Trabecular meshwork ( TM ) cells have widely been used as an invitro model for glaucoma research . However , primary TM cells suffer the disadvantages of limited cell numbers and slow rates of proliferation . We discovered a spontaneously transformed bovine TM ( BTM ) cell line , BTM-28T . This cell line proliferated rapidly in low-glucose culture medium but also demonstrated contact inhibition in high-glucose culture medium . BTM-28T cells expressed key TM cell markers including α-smooth muscle actin ( α-SMA ) , laminin and collagen IV ( col IV ) . Also , 100nM dexamethasone ( DEX ) enhanced the formation of cross-linked actin networks ( CLANs ) in confluent BTM-28T cell cultures . Transforming growth factor beta 2 ( TGFβ2 ) induced the expression of fibronectin ( FN ) , plasminogen activator inhibitor-1 ( PAI-1 ) , and connective tissue growth factor ( CTGF ) in our cell cultures . This cell line will be helpful to better understand the aqueous humor outflow pathway as related to the pathophysiology of glaucoma .
    OUTPUT:

agent
evading growth suppressors
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Trabecular meshwork ( TM ) cells have widely been used as an invitro model for glaucoma research . However , primary TM cells suffer the disadvantages of limited cell numbers and slow rates of proliferation . We discovered a spontaneously transformed bovine TM ( BTM ) cell line , BTM-28T . This cell line proliferated rapidly in low-glucose culture medium but also demonstrated contact inhibition in high-glucose culture medium . BTM-28T cells expressed key TM cell markers including α-smooth muscle actin ( α-SMA ) , laminin and collagen IV ( col IV ) . Also , 100nM dexamethasone ( DEX ) enhanced the formation of cross-linked actin networks ( CLANs ) in confluent BTM-28T cell cultures . Transforming growth factor beta 2 ( TGFβ2 ) induced the expression of fibronectin ( FN ) , plasminogen activator inhibitor-1 ( PAI-1 ) , and connective tissue growth factor ( CTGF ) in our cell cultures . This cell line will be helpful to better understand the aqueous humor outflow pathway as related to the pathophysiology of glaucoma .
    OUTPUT:
