human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Reactive oxygen species ( ROS ) produced by phagocytic cells induce oxidative stress during chronic inflammation . ROS play a role in the pathogenesis of a broad range of diseases including autoimmune , cardiac and neoplastic abnormalities . We found that sera of patients with a variety of inflammatory dermatoses contain elevated levels of antibodies ( Ab ) binding to an oxidized DNA base derivative , 5-hydroxymethyl-2'deoxyuridine ( HMdU ) coupled to bovine serum albumin , as determined by the enzyme-linked immunosorbent assay . Patients with immune complex diseases and a history of neoplasm elaborated the highest titers of anti-HMdU Ab . Titers from sera of psoriatic subjects were lower than from the aforementioned groups but were still significantly elevated ( p &lt ; 0.001 ) above those of healthy controls . Treatment of inflammatory dermatoses with systemic antiinflammatory and cytotoxic drugs significantly lowered the titers [ p &lt ; 0.005 ( immune complex ) or p &lt ; 0.001 ( psoriasis and neoplastic ) diseases ] , suggesting that this assay may be of value in monitoring the response to therapy in these diseases .
    OUTPUT:

agent
tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Reactive oxygen species ( ROS ) produced by phagocytic cells induce oxidative stress during chronic inflammation . ROS play a role in the pathogenesis of a broad range of diseases including autoimmune , cardiac and neoplastic abnormalities . We found that sera of patients with a variety of inflammatory dermatoses contain elevated levels of antibodies ( Ab ) binding to an oxidized DNA base derivative , 5-hydroxymethyl-2'deoxyuridine ( HMdU ) coupled to bovine serum albumin , as determined by the enzyme-linked immunosorbent assay . Patients with immune complex diseases and a history of neoplasm elaborated the highest titers of anti-HMdU Ab . Titers from sera of psoriatic subjects were lower than from the aforementioned groups but were still significantly elevated ( p &lt ; 0.001 ) above those of healthy controls . Treatment of inflammatory dermatoses with systemic antiinflammatory and cytotoxic drugs significantly lowered the titers [ p &lt ; 0.005 ( immune complex ) or p &lt ; 0.001 ( psoriasis and neoplastic ) diseases ] , suggesting that this assay may be of value in monitoring the response to therapy in these diseases .
    OUTPUT:
