human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Diffuse intrinsic pontine glioma ( DIPG ) is a fatal pediatric disease . Thus far no therapeutic agent has proven beneficial in the treatment of this malignancy . Hence , conventional DNA-damaging radiotherapy ( RT ) remains the standard treatment , providing transient neurological improvement without improving probability of overall survival . During RT , WEE1 kinase controls the G2 cell cycle checkpoint allowing for repair of irradiation ( IR)-induced DNA damage . Here we show that WEE1 kinase is one of the highest overexpressed kinases in primary DIPG tissues as compared to matching non-neoplastic brain tissues . Inhibition of WEE1 by MK-1775 treatment of DIPG cells inhibited the IR-induced WEE1-mediated phosphorylation of CDC2 , resulting in reduced G2/M arrest and decreased cell viability . Finally , we demonstrate that MK-1775 enhances the radiation response of E98-Fluc-mCherry DIPG mouse xenografts . Altogether , these results show that inhibition of WEE1 kinase in conjunction with RT holds potential as a therapeutic approach for the treatment of DIPG .
    OUTPUT:

agent
evading growth suppressors;sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Diffuse intrinsic pontine glioma ( DIPG ) is a fatal pediatric disease . Thus far no therapeutic agent has proven beneficial in the treatment of this malignancy . Hence , conventional DNA-damaging radiotherapy ( RT ) remains the standard treatment , providing transient neurological improvement without improving probability of overall survival . During RT , WEE1 kinase controls the G2 cell cycle checkpoint allowing for repair of irradiation ( IR)-induced DNA damage . Here we show that WEE1 kinase is one of the highest overexpressed kinases in primary DIPG tissues as compared to matching non-neoplastic brain tissues . Inhibition of WEE1 by MK-1775 treatment of DIPG cells inhibited the IR-induced WEE1-mediated phosphorylation of CDC2 , resulting in reduced G2/M arrest and decreased cell viability . Finally , we demonstrate that MK-1775 enhances the radiation response of E98-Fluc-mCherry DIPG mouse xenografts . Altogether , these results show that inhibition of WEE1 kinase in conjunction with RT holds potential as a therapeutic approach for the treatment of DIPG .
    OUTPUT:
