human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: DNA repair is essential in maintaining genome integrity and defects in different steps of the process have been linked to cancer and aging . It is a long lasting question how DNA repair is spatially and temporarily organized in the highly compartmentalized nucleus and whether the diverse nuclear compartments regulate differently the efficiency of repair . Increasing evidence suggest the involvement of nuclear pore complexes in repair of double-strand breaks ( DSBs ) in yeast . Here , we show that the human nucleoporin 153 ( NUP153 ) has a role in repair of DSBs and in the activation of DNA damage checkpoints . We explore the mechanism of action of NUP153 and we propose its potential as a novel therapeutic target in cancers .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: DNA repair is essential in maintaining genome integrity and defects in different steps of the process have been linked to cancer and aging . It is a long lasting question how DNA repair is spatially and temporarily organized in the highly compartmentalized nucleus and whether the diverse nuclear compartments regulate differently the efficiency of repair . Increasing evidence suggest the involvement of nuclear pore complexes in repair of double-strand breaks ( DSBs ) in yeast . Here , we show that the human nucleoporin 153 ( NUP153 ) has a role in repair of DSBs and in the activation of DNA damage checkpoints . We explore the mechanism of action of NUP153 and we propose its potential as a novel therapeutic target in cancers .
    OUTPUT:
