human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: ANXA2 , a member of the annexin family , is overexpressed and plays important roles in tumor development . However , the significance of ANXA2 expression in gastric carcinoma has not been clarified.To elucidate its roles in growth of gastric cancer , ANXA2 expression in SGC-7901 cells was inhibited with a designated siRNA , then cell proliferation , cell cycling , apoptosis and motility were determined by MTT assay , flow cytometry , Hoechst 33342 staining and wound healing assay , respectively . To further assess the behavior of ANXA2 deleted SGC- 7901 cells , changes of microstructures were observed under fluorescence microscopy , laser scanning confocal microscopy and electron microscopy . We found that inhibition of ANXA2 expression caused cell proliferation to decrease significantly with G1 arrest , motility to be reduced with changes in pseudopodia/filopodia structure and F-actin and Î²-tubulin expression , and apoptosis to be enhanced albeit without significance . At the same time , ANXA2 deletion resulted in fewer pseudopodia/filopodia , non-stained areas were increased , contact inhibition among cells reappeared , and expression of F-actin and Î²-tubulin was decreased , with induction of polymerized disassembled forms . Taken together , these data suggest that ANXA2 overexpression is important to maintain the malignancy of cancer cells , and this member of the annexin family has potential to be considered as a target for the gene therapy of gastric carcinoma .
    OUTPUT:

agent
evading growth suppressors;resisting cell death;sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: ANXA2 , a member of the annexin family , is overexpressed and plays important roles in tumor development . However , the significance of ANXA2 expression in gastric carcinoma has not been clarified.To elucidate its roles in growth of gastric cancer , ANXA2 expression in SGC-7901 cells was inhibited with a designated siRNA , then cell proliferation , cell cycling , apoptosis and motility were determined by MTT assay , flow cytometry , Hoechst 33342 staining and wound healing assay , respectively . To further assess the behavior of ANXA2 deleted SGC- 7901 cells , changes of microstructures were observed under fluorescence microscopy , laser scanning confocal microscopy and electron microscopy . We found that inhibition of ANXA2 expression caused cell proliferation to decrease significantly with G1 arrest , motility to be reduced with changes in pseudopodia/filopodia structure and F-actin and Î²-tubulin expression , and apoptosis to be enhanced albeit without significance . At the same time , ANXA2 deletion resulted in fewer pseudopodia/filopodia , non-stained areas were increased , contact inhibition among cells reappeared , and expression of F-actin and Î²-tubulin was decreased , with induction of polymerized disassembled forms . Taken together , these data suggest that ANXA2 overexpression is important to maintain the malignancy of cancer cells , and this member of the annexin family has potential to be considered as a target for the gene therapy of gastric carcinoma .
    OUTPUT:
