human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Metastases in the sellar region are rare and are frequently found incidentally or in necropsies . Only 7% are reported to be symptomatic . Diabetes insipidus , anterior pituitary dysfunction , visual field defects , headache/pain and ophthalmoplegia are the most commonly reported symptoms . We present the cases of two male patients with a small-cell lung carcinoma whose first clinical symptoms were due to pituitary metastasis . One case presented with symptoms of cavernous sinus invasion and panhypopituitarism and the other case with diabetes insipidus . Both patients had a rapid progression of their disease despite chemotherapy and died after a few months . Pituitary metastases occur most commonly with breast cancer in women and lung cancer in men . The presence of polyuria and polydipsia in an oncologic patient should alert the physician for diabetes insipidus and , if confirmed , an imaging procedure of the pituitary gland is mandatory . Treatment for these tumors is often multimodal and includes surgery , radiation therapy , chemotherapy and hormone replacement . Although surgical series have not shown any significant survival benefits given by tumor resection , the patient's quality of life may be improved .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Metastases in the sellar region are rare and are frequently found incidentally or in necropsies . Only 7% are reported to be symptomatic . Diabetes insipidus , anterior pituitary dysfunction , visual field defects , headache/pain and ophthalmoplegia are the most commonly reported symptoms . We present the cases of two male patients with a small-cell lung carcinoma whose first clinical symptoms were due to pituitary metastasis . One case presented with symptoms of cavernous sinus invasion and panhypopituitarism and the other case with diabetes insipidus . Both patients had a rapid progression of their disease despite chemotherapy and died after a few months . Pituitary metastases occur most commonly with breast cancer in women and lung cancer in men . The presence of polyuria and polydipsia in an oncologic patient should alert the physician for diabetes insipidus and , if confirmed , an imaging procedure of the pituitary gland is mandatory . Treatment for these tumors is often multimodal and includes surgery , radiation therapy , chemotherapy and hormone replacement . Although surgical series have not shown any significant survival benefits given by tumor resection , the patient's quality of life may be improved .
    OUTPUT:
