human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: BACKGROUND Angiogenesis plays an important role in the progression of colorectal cancer ( CRC ) . Studies have indicated vascular endothelial growth factor ( VEGF ) is the predominant angiogenic factor . Cyclin D1 ( CCND1 ) induces production of VEGF and is required for migration of blood vessels . Our aim was to determine the roles of CCND1 and VEGF overexpression in CRC patients . METHODS We analyzed clinicopathological features , VEGF and CCND1 expressions by immunohistochemical ( IHC ) staining in 100 stage I-III CRC patients ( 44 were postoperative relapsed ; 56 were postoperative non-relapsed ) to determine the correlation between clinicopathologic features and co-existence of CCND1 and VEGF . Furthermore , the clinical outcomes of co-existence of CCND1 and VEGF were investigated . RESULTS Multivariate analysis showed vascular invasion ( P = 0.019 ) , VEGF overexpression ( P = 0.033 ) , and high postoperative serum carcinoembryonic antigen ( CEA ) levels ( P = 0.022 ) were independent predictors of postoperative relapse . Co-existence of CCND1 and VEGF overexpression had significantly poorer disease-free survival rates ( P â= 0.004 ) and overall survival rates ( P = 0.001 ) than other phenotypes . CONCLUSIONS Co-existence of CCND1 and VEGF overexpression would potentially assist in TNM staging systems to predict the prognosis of these patients who would benefit from intensive follow-up and therapeutic programs .
    OUTPUT:

agent
inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: BACKGROUND Angiogenesis plays an important role in the progression of colorectal cancer ( CRC ) . Studies have indicated vascular endothelial growth factor ( VEGF ) is the predominant angiogenic factor . Cyclin D1 ( CCND1 ) induces production of VEGF and is required for migration of blood vessels . Our aim was to determine the roles of CCND1 and VEGF overexpression in CRC patients . METHODS We analyzed clinicopathological features , VEGF and CCND1 expressions by immunohistochemical ( IHC ) staining in 100 stage I-III CRC patients ( 44 were postoperative relapsed ; 56 were postoperative non-relapsed ) to determine the correlation between clinicopathologic features and co-existence of CCND1 and VEGF . Furthermore , the clinical outcomes of co-existence of CCND1 and VEGF were investigated . RESULTS Multivariate analysis showed vascular invasion ( P = 0.019 ) , VEGF overexpression ( P = 0.033 ) , and high postoperative serum carcinoembryonic antigen ( CEA ) levels ( P = 0.022 ) were independent predictors of postoperative relapse . Co-existence of CCND1 and VEGF overexpression had significantly poorer disease-free survival rates ( P â= 0.004 ) and overall survival rates ( P = 0.001 ) than other phenotypes . CONCLUSIONS Co-existence of CCND1 and VEGF overexpression would potentially assist in TNM staging systems to predict the prognosis of these patients who would benefit from intensive follow-up and therapeutic programs .
    OUTPUT:
