human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The prediction of tumor behavior for patients with oral carcinomas remains a challenge for clinicians . The presence of lymph node metastasis is the most important prognostic factor but it is limited in predicting local relapse or survival . This highlights the need for identifying biomarkers that may effectively contribute to prediction of recurrence and tumor spread . In this study , we used one- and two-dimensional gel electrophoresis , mass spectrometry and immunodetection methods to analyze protein expression in oral squamous cell carcinomas . Using a refinement for classifying oral carcinomas in regard to prognosis , we analyzed small but lymph node metastasis-positive versus large , lymph node metastasis-negative tumors in order to contribute to the molecular characterization of subgroups with risk of dissemination . Specific protein patterns favoring metastasis were observed in the " more-aggressive " group defined by the present study . This group displayed upregulation of proteins involved in migration , adhesion , angiogenesis , cell cycle regulation , anti-apoptosis and epithelial to mesenchymal transition , whereas the " less-aggressive " group was engaged in keratinocyte differentiation , epidermis development , inflammation and immune response . Besides the identification of several proteins not yet described as deregulated in oral carcinomas , the present study demonstrated for the first time the role of cofilin-1 in modulating cell invasion in oral carcinomas .
    OUTPUT:

agent
activating invasion and metastasis;inducing angiogenesis;resisting cell death;sustaining proliferative signaling;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The prediction of tumor behavior for patients with oral carcinomas remains a challenge for clinicians . The presence of lymph node metastasis is the most important prognostic factor but it is limited in predicting local relapse or survival . This highlights the need for identifying biomarkers that may effectively contribute to prediction of recurrence and tumor spread . In this study , we used one- and two-dimensional gel electrophoresis , mass spectrometry and immunodetection methods to analyze protein expression in oral squamous cell carcinomas . Using a refinement for classifying oral carcinomas in regard to prognosis , we analyzed small but lymph node metastasis-positive versus large , lymph node metastasis-negative tumors in order to contribute to the molecular characterization of subgroups with risk of dissemination . Specific protein patterns favoring metastasis were observed in the " more-aggressive " group defined by the present study . This group displayed upregulation of proteins involved in migration , adhesion , angiogenesis , cell cycle regulation , anti-apoptosis and epithelial to mesenchymal transition , whereas the " less-aggressive " group was engaged in keratinocyte differentiation , epidermis development , inflammation and immune response . Besides the identification of several proteins not yet described as deregulated in oral carcinomas , the present study demonstrated for the first time the role of cofilin-1 in modulating cell invasion in oral carcinomas .
    OUTPUT:
