human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The purpose of the study was to evaluate Sorafenib ( BAY 43-9006 ) derived receptor tyrosine kinase inhibition on tumor progression in murine islet cell tumors . Sorafenib is considered to be a potent inhibitor of tumor angiogenesis and neovascularization in various solid tumors . Rip1Tag2 mice were treated in two different groups according to the model of tumor progression : the early treatment group received vehicle or Sorafenib from 10 to 14 weeks of age and the late treatment group from week 12 until death . Tumor surface , tumor cell proliferation , and apoptosis were measured in both treatment groups to assess the in vivo effects of Sorafenib . Survival was recorded for the late treatment group . In the early treatment group Sorafenib led to a dramatic decrease in tumor volume compared to the control group . Apoptosis was significantly augmented and cell proliferation was inhibited . As a single therapy Sorafenib significantly improved survival in the late treatment group . Conclusion . Sorafenib may provide a new paradigm for the therapy of islet cell tumors .
    OUTPUT:

agent
resisting cell death;sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The purpose of the study was to evaluate Sorafenib ( BAY 43-9006 ) derived receptor tyrosine kinase inhibition on tumor progression in murine islet cell tumors . Sorafenib is considered to be a potent inhibitor of tumor angiogenesis and neovascularization in various solid tumors . Rip1Tag2 mice were treated in two different groups according to the model of tumor progression : the early treatment group received vehicle or Sorafenib from 10 to 14 weeks of age and the late treatment group from week 12 until death . Tumor surface , tumor cell proliferation , and apoptosis were measured in both treatment groups to assess the in vivo effects of Sorafenib . Survival was recorded for the late treatment group . In the early treatment group Sorafenib led to a dramatic decrease in tumor volume compared to the control group . Apoptosis was significantly augmented and cell proliferation was inhibited . As a single therapy Sorafenib significantly improved survival in the late treatment group . Conclusion . Sorafenib may provide a new paradigm for the therapy of islet cell tumors .
    OUTPUT:
