human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Manipulating acetylation status of key gene targets is likely to be crucial for effective cancer therapy . In this study , we utilized green tea catechins , epicatechin ( EC ) , epigallocatechin ( EGC ) and epigallocatechin-3-gallate ( EGCG ) to examine the regulation of androgen receptor acetylation in androgen-dependent prostate cancer cells by histone acetyl-transferase ( HAT ) activity . EC , EGC and EGCG induced prostate cancer cell death , suppressed agonist-dependent androgen receptor ( AR ) activation and AR-regulated gene transcription . These results demonstrated a similar tendency to HAT inhibitory activities ; EGCG&gt;EGC&gt;EC . The strongest HAT inhibitor among them , EGCG ( 50 ï¿½M ) , downregulated AR acetylation and finally , AR protein translocation to nucleus from the cytoplasmic compartment was effectively inhibited in the presence of the agonist . These results suggest another mechanism to develop effective therapeutics based on green tea catechins .
    OUTPUT:

agent
resisting cell death;sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Manipulating acetylation status of key gene targets is likely to be crucial for effective cancer therapy . In this study , we utilized green tea catechins , epicatechin ( EC ) , epigallocatechin ( EGC ) and epigallocatechin-3-gallate ( EGCG ) to examine the regulation of androgen receptor acetylation in androgen-dependent prostate cancer cells by histone acetyl-transferase ( HAT ) activity . EC , EGC and EGCG induced prostate cancer cell death , suppressed agonist-dependent androgen receptor ( AR ) activation and AR-regulated gene transcription . These results demonstrated a similar tendency to HAT inhibitory activities ; EGCG&gt;EGC&gt;EC . The strongest HAT inhibitor among them , EGCG ( 50 ï¿½M ) , downregulated AR acetylation and finally , AR protein translocation to nucleus from the cytoplasmic compartment was effectively inhibited in the presence of the agonist . These results suggest another mechanism to develop effective therapeutics based on green tea catechins .
    OUTPUT:
