human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: We present a novel gain-of-function mutation of TGF-Î² receptor II ( TÎ²RII ) found in human oral squamous cell carcinoma ( OSCC ) . Expression of E221V/N238I mutant TÎ²RII enhanced TGF-Î² signaling . Mutation of TÎ²RII conferred cells higher migratory and invasive capabilities and MMP-2 activity . In mouse tumor model , mutant tumors exhibited poor differentiation and E-cadherin relocalization to the cytosol . Lipid-raft-dependent endocytosis of TÎ²RII was attenuated in mutant TÎ²RII , suggesting that enhancement of TGF-Î² signaling by this mutation is due to delayed TÎ²RII internalization . Taken together , our results show a novel gain-of-function TÎ²RII mutation , which enhances TGF-Î² signaling leading to more invasive phenotypic changes in human OSCC .
    OUTPUT:

agent
genomic instability and mutation;sustaining proliferative signaling;activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: We present a novel gain-of-function mutation of TGF-Î² receptor II ( TÎ²RII ) found in human oral squamous cell carcinoma ( OSCC ) . Expression of E221V/N238I mutant TÎ²RII enhanced TGF-Î² signaling . Mutation of TÎ²RII conferred cells higher migratory and invasive capabilities and MMP-2 activity . In mouse tumor model , mutant tumors exhibited poor differentiation and E-cadherin relocalization to the cytosol . Lipid-raft-dependent endocytosis of TÎ²RII was attenuated in mutant TÎ²RII , suggesting that enhancement of TGF-Î² signaling by this mutation is due to delayed TÎ²RII internalization . Taken together , our results show a novel gain-of-function TÎ²RII mutation , which enhances TGF-Î² signaling leading to more invasive phenotypic changes in human OSCC .
    OUTPUT:
