human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Overexpression of the melanoma differentiation associated gene-7 ( MDA-7)/IL-24 in vitro generally results in the growth suppression and induction of apoptosis of diverse human tumor cells . In this study , we investigated the effects of overexpression of the MDA-7/IL-24 gene in human hepatocellular carcinoma ( HCC ) cells in vitro and in vivo . Adenovirus-mediated overexpression of MDA-7 facilitated the MDA-7/IL-24-induced apoptosis and G2/M arrest in HCC cells , but not in the normal liver cell line L02 , and the effect was independent of the p53 status . Inhibition of metastasis and angiogenesis was correlated with decreasing expression of STAT3 , P-STAT3 , MMP-2 , VEGF , and TGF-beta genes , regulated by STAT3 in MHCCLM6 cells . We also showed that Ad.mda-7 combined with doxorubicin ( ADM ) had significantly enhanced antitumor and antimetastatic effects in vivo , accompanied by the downregulation of VEGF , MMP-2 , and TGF-beta genes and the upregulation of E-cadherin genes . These data suggested that MDA-7/IL-24 induces its selective antitumor properties in HCC cells by promoting apoptosis independent of p53 status , inhibiting subcutaneous tumor growth and metastasis , and increasing the effect of chemotherapeutic agents . MDA-7/IL-24 represents a new class of cancer suppressor genes that may be useful in the targeted therapy of HCC .
    OUTPUT:

agent
evading growth suppressors;activating invasion and metastasis;inducing angiogenesis;sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Overexpression of the melanoma differentiation associated gene-7 ( MDA-7)/IL-24 in vitro generally results in the growth suppression and induction of apoptosis of diverse human tumor cells . In this study , we investigated the effects of overexpression of the MDA-7/IL-24 gene in human hepatocellular carcinoma ( HCC ) cells in vitro and in vivo . Adenovirus-mediated overexpression of MDA-7 facilitated the MDA-7/IL-24-induced apoptosis and G2/M arrest in HCC cells , but not in the normal liver cell line L02 , and the effect was independent of the p53 status . Inhibition of metastasis and angiogenesis was correlated with decreasing expression of STAT3 , P-STAT3 , MMP-2 , VEGF , and TGF-beta genes , regulated by STAT3 in MHCCLM6 cells . We also showed that Ad.mda-7 combined with doxorubicin ( ADM ) had significantly enhanced antitumor and antimetastatic effects in vivo , accompanied by the downregulation of VEGF , MMP-2 , and TGF-beta genes and the upregulation of E-cadherin genes . These data suggested that MDA-7/IL-24 induces its selective antitumor properties in HCC cells by promoting apoptosis independent of p53 status , inhibiting subcutaneous tumor growth and metastasis , and increasing the effect of chemotherapeutic agents . MDA-7/IL-24 represents a new class of cancer suppressor genes that may be useful in the targeted therapy of HCC .
    OUTPUT:
