human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Cell kinetics and activity of ornithine decarboxylase ( ODC ) were studied during the process of 1-hydroxyanthraquinone ( 1-HA)-induced intestinal carcinogenesis in rats . Starting at 6 weeks of age , a total of 37 male ACI/N rats were divided into two groups and treated as follows : group I ( 18 rats ) received diet containing 1% 1-HA for 12 months ; group II ( 19 rats ) was given the basal diet alone . Sub-groups of 5-7 rats were sequentially killed at 4 , 8 and 12 months for evaluation of the length , cell numbers and 5-bromo-2'-deoxyuridine ( BrDU ) labeling indices of large bowel crypts together with ODC activity . All kinetic and ODC data indicated increased DNA synthesis and proliferation at all time points . Morphological observation of the intestines also revealed melanosis , crypt abscesses and erosion , becoming more pronounced with length of exposure to the anthraquinone . The data thus suggest that cell proliferation in the crypts of the cecum or colon is important for 1-HA-induced intestinal carcinogenesis .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Cell kinetics and activity of ornithine decarboxylase ( ODC ) were studied during the process of 1-hydroxyanthraquinone ( 1-HA)-induced intestinal carcinogenesis in rats . Starting at 6 weeks of age , a total of 37 male ACI/N rats were divided into two groups and treated as follows : group I ( 18 rats ) received diet containing 1% 1-HA for 12 months ; group II ( 19 rats ) was given the basal diet alone . Sub-groups of 5-7 rats were sequentially killed at 4 , 8 and 12 months for evaluation of the length , cell numbers and 5-bromo-2'-deoxyuridine ( BrDU ) labeling indices of large bowel crypts together with ODC activity . All kinetic and ODC data indicated increased DNA synthesis and proliferation at all time points . Morphological observation of the intestines also revealed melanosis , crypt abscesses and erosion , becoming more pronounced with length of exposure to the anthraquinone . The data thus suggest that cell proliferation in the crypts of the cecum or colon is important for 1-HA-induced intestinal carcinogenesis .
    OUTPUT:
