human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Mast cells ( MC ) are key effector cells in allergic reactions but also involved in host defence , tissue remodeling , angiogenesis , and fibrogenesis . Here , we show that human intestinal fibroblasts ( FB ) suppress apoptosis in human intestinal MC dependent on IL-6 . Intestinal FB produced IL-6 upon direct stimulation by intestinal MC in co-culture or by MC mediators such as TNF-Î± , IL-1Î² , tryptase or histamine . MC incubated with IL-6 survived for up to 3 weeks similar to MC co-cultured with FB and MC survival could be blocked by neutralizing anti-IL-6 Abs . Moreover , FB stimulated by MC mediators upregulated their expression of matrix metalloproteinase-1 ( MMP-1 ) , a key fibrolytic enzyme . Noteworthy , FB co-cultured with MC or treated with MMP-1 lost confluence and showed increased numbers of apoptotic cells . Our data indicate an intimate cross talk between mucosal MC and FB resulting in MC survival and induction of a fibrolytic rather than a profibrotic state in FB .
    OUTPUT:

agent
resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Mast cells ( MC ) are key effector cells in allergic reactions but also involved in host defence , tissue remodeling , angiogenesis , and fibrogenesis . Here , we show that human intestinal fibroblasts ( FB ) suppress apoptosis in human intestinal MC dependent on IL-6 . Intestinal FB produced IL-6 upon direct stimulation by intestinal MC in co-culture or by MC mediators such as TNF-Î± , IL-1Î² , tryptase or histamine . MC incubated with IL-6 survived for up to 3 weeks similar to MC co-cultured with FB and MC survival could be blocked by neutralizing anti-IL-6 Abs . Moreover , FB stimulated by MC mediators upregulated their expression of matrix metalloproteinase-1 ( MMP-1 ) , a key fibrolytic enzyme . Noteworthy , FB co-cultured with MC or treated with MMP-1 lost confluence and showed increased numbers of apoptotic cells . Our data indicate an intimate cross talk between mucosal MC and FB resulting in MC survival and induction of a fibrolytic rather than a profibrotic state in FB .
    OUTPUT:
