human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Background . Multiple myeloma ( MM ) , an almost incurable disease , is the second most common blood cancer . Initial chemotherapeutic treatment could be successful ; however , resistance development urges the use of higher toxic doses accompanied by hematopoietic stem cell transplantation . The establishment of more effective treatments that can overcome or circumvent chemoresistance has become a priority . We recently demonstrated that venom extracted from Walterinnesia aegyptia ( WEV ) either alone or in combination with silica nanoparticles ( WEV+NPs ) mediated the growth arrest and apoptosis of prostate cancer cells . In the present study , we evaluated the impact of WEV alone and WEV+NP on proliferation and apoptosis of MM cells . Methods . The impacts of WEV alone and WEV+NP were monitored in MM cells from 70 diagnosed patients . The influences of WEV and WEV+NP were assessed with flow cytometry analysis . Results . WEV alone and WEV+NP decreased the viability of MM cells . Using a CFSE proliferation assay , we found that WEV+NP strongly inhibited MM cell proliferation . Furthermore , analysis of the cell cycle using the propidium iodide ( PI ) staining method indicated that WEV+NP strongly altered the cell cycle of MM cells and enhanced the induction of apoptosis . Conclusions . Our data reveal the biological effects of WEV and WEV+NP on MM cells that enable these compounds to function as effective treatments for MM .
    OUTPUT:

agent
sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Background . Multiple myeloma ( MM ) , an almost incurable disease , is the second most common blood cancer . Initial chemotherapeutic treatment could be successful ; however , resistance development urges the use of higher toxic doses accompanied by hematopoietic stem cell transplantation . The establishment of more effective treatments that can overcome or circumvent chemoresistance has become a priority . We recently demonstrated that venom extracted from Walterinnesia aegyptia ( WEV ) either alone or in combination with silica nanoparticles ( WEV+NPs ) mediated the growth arrest and apoptosis of prostate cancer cells . In the present study , we evaluated the impact of WEV alone and WEV+NP on proliferation and apoptosis of MM cells . Methods . The impacts of WEV alone and WEV+NP were monitored in MM cells from 70 diagnosed patients . The influences of WEV and WEV+NP were assessed with flow cytometry analysis . Results . WEV alone and WEV+NP decreased the viability of MM cells . Using a CFSE proliferation assay , we found that WEV+NP strongly inhibited MM cell proliferation . Furthermore , analysis of the cell cycle using the propidium iodide ( PI ) staining method indicated that WEV+NP strongly altered the cell cycle of MM cells and enhanced the induction of apoptosis . Conclusions . Our data reveal the biological effects of WEV and WEV+NP on MM cells that enable these compounds to function as effective treatments for MM .
    OUTPUT:
