human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Our previous study demonstrated that 5-aminolevulinic acid ( ALA ) administered to mice stimulates oxidative phosphorylation by upregulation of the mitochondrial respiratory chain complex IV enzyme cytochrome c oxidase ( COX ) . The present study investigated whether ALA disrupts the Warburg effect , which represents a shift in ATP generation from oxidative phosphorylation to glycolysis , protecting tumor cells against oxidative stress-mediated apoptosis . The human lung carcinoma cell line A549 exposed to ALA exhibited enhanced oxidative phosphorylation , which was indicated by an increase in COX protein expression and oxygen consumption . Furthermore , ALA suppressed glycolysis-mediated acidosis . This normalization of the ATP metabolic pathways significantly increased the generation of superoxide anion radical ( O2•- ) and the functional expression of active caspase-3 , leading to caspase-dependent apoptosis . These data demonstrate that ALA inhibits the Warburg effect and induces cancer cell death . Use of this endogenous compound might constitute a novel approach to cancer therapy .
    OUTPUT:

agent
cellular energetics;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Our previous study demonstrated that 5-aminolevulinic acid ( ALA ) administered to mice stimulates oxidative phosphorylation by upregulation of the mitochondrial respiratory chain complex IV enzyme cytochrome c oxidase ( COX ) . The present study investigated whether ALA disrupts the Warburg effect , which represents a shift in ATP generation from oxidative phosphorylation to glycolysis , protecting tumor cells against oxidative stress-mediated apoptosis . The human lung carcinoma cell line A549 exposed to ALA exhibited enhanced oxidative phosphorylation , which was indicated by an increase in COX protein expression and oxygen consumption . Furthermore , ALA suppressed glycolysis-mediated acidosis . This normalization of the ATP metabolic pathways significantly increased the generation of superoxide anion radical ( O2•- ) and the functional expression of active caspase-3 , leading to caspase-dependent apoptosis . These data demonstrate that ALA inhibits the Warburg effect and induces cancer cell death . Use of this endogenous compound might constitute a novel approach to cancer therapy .
    OUTPUT:
