human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Glycolysis is known to be the primary energy source in most cancer cells . We investigated here the effect of clotrimazole ( 1-(alpha-2-chlorotrityl)imidazole ) , the antifungal azole derivative , which was recently recognized as calmodulin antagonist , on the levels of glucose 1,6-bisphosphate and fructose 1,6-bisphosphate , the two stimulatory signal molecules of glycolysis , and on ATP content and cell viability in LL/2 Lewis lung carcinoma cells and CT-26 colon adenocarcinoma cells . We found that clotrimazole induced a significant , dose- and time-dependent reduction in the levels of glucose 1,6-bisphosphate , fructose 1,6-bisphosphate , ATP , and cell viability . These findings suggest that clotrimazole causes a reduction in glycolysis and ATP levels , which eventually leads to cell destruction after 3 h of treatment . Since cell proliferation was also reported to be inhibited by calmodulin antagonists , this substance is most promising agent in treatment of cancer by inhibiting both cell proliferation and the glycolytic supply of ATP required for cancer cell growth .
    OUTPUT:

agent
cellular energetics
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Glycolysis is known to be the primary energy source in most cancer cells . We investigated here the effect of clotrimazole ( 1-(alpha-2-chlorotrityl)imidazole ) , the antifungal azole derivative , which was recently recognized as calmodulin antagonist , on the levels of glucose 1,6-bisphosphate and fructose 1,6-bisphosphate , the two stimulatory signal molecules of glycolysis , and on ATP content and cell viability in LL/2 Lewis lung carcinoma cells and CT-26 colon adenocarcinoma cells . We found that clotrimazole induced a significant , dose- and time-dependent reduction in the levels of glucose 1,6-bisphosphate , fructose 1,6-bisphosphate , ATP , and cell viability . These findings suggest that clotrimazole causes a reduction in glycolysis and ATP levels , which eventually leads to cell destruction after 3 h of treatment . Since cell proliferation was also reported to be inhibited by calmodulin antagonists , this substance is most promising agent in treatment of cancer by inhibiting both cell proliferation and the glycolytic supply of ATP required for cancer cell growth .
    OUTPUT:
