human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Psoralen photoreaction with DNA produces interstrand crosslinks , which require the activity of excision and recombinational pathways for repair . Yeast replicating plasmids , carrying the HIS3 , TRP1 , and URA3 genes , were photoreacted with psoralen in vitro and transfected into Saccharomyces cerevisiae cells . Repair was assayed as the relative transformation efficiency . A recombination-deficient rad52 strain was the least efficient in the repair of psoralen-damaged plasmids ; excision repair-deficient rad1 and rad3 strains had repair efficiencies intermediate between those of rad52 and RAD cells . The level of repair also depended on the conditions of transformant selection ; repair was more efficient in medium lacking tryptophan than in medium from which either histidine or uracil was omitted . The plasmid repair differential between these selective media was greatest in rad1 cells , and depended on RAD52 . Plasmid-chromosome recombination was stimulated by psoralen damage , and required RAD52 function . Chromosome to plasmid gene conversion was seen most frequently at the HIS3 locus . In RAD and rad3 cells , the majority of the conversions were associated with plasmid integration , while in rad1 cells most were non-crossover events . Plasmid to chromosome gene conversion was observed most frequently at the TRP1 locus , and was accompanied by plasmid loss .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Psoralen photoreaction with DNA produces interstrand crosslinks , which require the activity of excision and recombinational pathways for repair . Yeast replicating plasmids , carrying the HIS3 , TRP1 , and URA3 genes , were photoreacted with psoralen in vitro and transfected into Saccharomyces cerevisiae cells . Repair was assayed as the relative transformation efficiency . A recombination-deficient rad52 strain was the least efficient in the repair of psoralen-damaged plasmids ; excision repair-deficient rad1 and rad3 strains had repair efficiencies intermediate between those of rad52 and RAD cells . The level of repair also depended on the conditions of transformant selection ; repair was more efficient in medium lacking tryptophan than in medium from which either histidine or uracil was omitted . The plasmid repair differential between these selective media was greatest in rad1 cells , and depended on RAD52 . Plasmid-chromosome recombination was stimulated by psoralen damage , and required RAD52 function . Chromosome to plasmid gene conversion was seen most frequently at the HIS3 locus . In RAD and rad3 cells , the majority of the conversions were associated with plasmid integration , while in rad1 cells most were non-crossover events . Plasmid to chromosome gene conversion was observed most frequently at the TRP1 locus , and was accompanied by plasmid loss .
    OUTPUT:
