human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Angiotensin II type 1 receptor ( AT1R ) promotes tumor invasion , migration , metastasis and angiogenesis . We explored the potential antitumor effects of AT1R antagonists in breast cancer . We found that angiotensin II promoted cell proliferation and upregulated the expression of vascular endothelial growth factor A ( VEGF-A ) in MCF-7 cells . Losartan downregulated the expression of VEGF-A in MCF-7 cells treated with angiotensin II . Candesartan downregulated the expression of VEGF-A in mice bearing MCF-7 xenografts and inhibited tumor growth and angiogenesis . AT1R and VEGF-A expression correlated with increased microvascular density in 102 breast cancer patients . Our data suggest that AT1R antagonists might be useful to suppress breast cancer by inhibiting the angiotensin II .
    OUTPUT:

agent
inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Angiotensin II type 1 receptor ( AT1R ) promotes tumor invasion , migration , metastasis and angiogenesis . We explored the potential antitumor effects of AT1R antagonists in breast cancer . We found that angiotensin II promoted cell proliferation and upregulated the expression of vascular endothelial growth factor A ( VEGF-A ) in MCF-7 cells . Losartan downregulated the expression of VEGF-A in MCF-7 cells treated with angiotensin II . Candesartan downregulated the expression of VEGF-A in mice bearing MCF-7 xenografts and inhibited tumor growth and angiogenesis . AT1R and VEGF-A expression correlated with increased microvascular density in 102 breast cancer patients . Our data suggest that AT1R antagonists might be useful to suppress breast cancer by inhibiting the angiotensin II .
    OUTPUT:
