human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: High-throughput screening of a small-molecule library identified a 5-triazolo-2-arylpyridazinone as a novel inhibitor of the important glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 ( PFKFB3 ) . Such inhibitors are of interest due to PFKFB3's control of the important glycolytic pathway used by cancer cells to generate ATP . A series of analogues was synthesized to study structure-activity relationships key to enzyme inhibition . Changes to the triazolo or pyridazinone rings were not favoured , but limited-size substitutions on the aryl ring provided modest increases in potency against the enzyme . Selected analogues and literature-described inhibitors were evaluated for their ability to suppress the glycolytic pathway , as detected by a decrease in lactate production , but none of these compounds demonstrated such suppression at non-cytotoxic concentrations .
    OUTPUT:

agent
cellular energetics
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: High-throughput screening of a small-molecule library identified a 5-triazolo-2-arylpyridazinone as a novel inhibitor of the important glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 ( PFKFB3 ) . Such inhibitors are of interest due to PFKFB3's control of the important glycolytic pathway used by cancer cells to generate ATP . A series of analogues was synthesized to study structure-activity relationships key to enzyme inhibition . Changes to the triazolo or pyridazinone rings were not favoured , but limited-size substitutions on the aryl ring provided modest increases in potency against the enzyme . Selected analogues and literature-described inhibitors were evaluated for their ability to suppress the glycolytic pathway , as detected by a decrease in lactate production , but none of these compounds demonstrated such suppression at non-cytotoxic concentrations .
    OUTPUT:
