human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The aryl hydrocarbon receptor ( AhR ) is a ligand-activated transcription factor . Recent studies have reported the anti-tumor effects of the AhR in breast cancer . In this study , we investigated the anti-tumor effect of AhR activation based on the cancer stem cell hypothesis . We show that AhR activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high ALDH-1 ( aldehyde dehydrogenase 1 ) activity . In addition , we also demonstrate that AhR activation regulates self-renewal signaling by down-regulating Wnt/Î²-catenin and Notch .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The aryl hydrocarbon receptor ( AhR ) is a ligand-activated transcription factor . Recent studies have reported the anti-tumor effects of the AhR in breast cancer . In this study , we investigated the anti-tumor effect of AhR activation based on the cancer stem cell hypothesis . We show that AhR activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high ALDH-1 ( aldehyde dehydrogenase 1 ) activity . In addition , we also demonstrate that AhR activation regulates self-renewal signaling by down-regulating Wnt/Î²-catenin and Notch .
    OUTPUT:
