human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Depression is the most common psychiatric syndrome in cancer patients and adversely affects anti-cancer immune system and life quality of patients . Antidepressant desipramine ( DMI ) is clinically prescribed in the auxiliary treatment of cancer patients . Increasing evidences suggest that DMI has a broad spectrum of target-off biological effects , such as anticancer properties . Our previous study revealed that DMI at the clinical relevant concentrations could induce CHOP-dependent apoptotic death in C6 glioma cells . In this study , we further explored the pro-autophagic effect of DMI in C6 glioma cells and its underlying mechanism . Treatment with DMI could induce autophagic cell death characterized by the formation of autophagosome and the elevated level of autophagic protein Beclin-1 and cellular redistribution of marker LC3 . Meanwhile , DMI inhibited the activation of PI3K-AKT-mTOR pathway which is considered as a negative regulator of autophagy . Furthermore , DMI activated PERK-eIF2Î± and ATF6 of endoplasmic reticulum ( ER ) stress pathway , while knockdown of PERK with the PERK-specific short interfering RNA ( siRNA ) could obviously attenuate the autophagy . The results strongly suggested that DMI could induce autophagy through the PERK-ER stress pathway in C6 glioma cells . Our findings provided new insights into another beneficial potential of antidepressant DMI in the adjuvant therapy of cancer .
    OUTPUT:

agent
resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Depression is the most common psychiatric syndrome in cancer patients and adversely affects anti-cancer immune system and life quality of patients . Antidepressant desipramine ( DMI ) is clinically prescribed in the auxiliary treatment of cancer patients . Increasing evidences suggest that DMI has a broad spectrum of target-off biological effects , such as anticancer properties . Our previous study revealed that DMI at the clinical relevant concentrations could induce CHOP-dependent apoptotic death in C6 glioma cells . In this study , we further explored the pro-autophagic effect of DMI in C6 glioma cells and its underlying mechanism . Treatment with DMI could induce autophagic cell death characterized by the formation of autophagosome and the elevated level of autophagic protein Beclin-1 and cellular redistribution of marker LC3 . Meanwhile , DMI inhibited the activation of PI3K-AKT-mTOR pathway which is considered as a negative regulator of autophagy . Furthermore , DMI activated PERK-eIF2Î± and ATF6 of endoplasmic reticulum ( ER ) stress pathway , while knockdown of PERK with the PERK-specific short interfering RNA ( siRNA ) could obviously attenuate the autophagy . The results strongly suggested that DMI could induce autophagy through the PERK-ER stress pathway in C6 glioma cells . Our findings provided new insights into another beneficial potential of antidepressant DMI in the adjuvant therapy of cancer .
    OUTPUT:
