human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: One classical feature of cancer cells is their metabolic acquisition of a highly glycolytic phenotype . Carbon monoxide ( CO ) , one of the products of the cytoprotective molecule heme oxygenase-1 ( HO-1 ) in cancer cells , has been implicated in carcinogenesis and therapeutic resistance . However , the functional contributions of CO and HO-1 to these processes are poorly defined . In human prostate cancers , we found that HO-1 was nuclear localized in malignant cells , with low enzymatic activity in moderately differentiated tumors correlating with relatively worse clinical outcomes . Exposure to CO sensitized prostate cancer cells but not normal cells to chemotherapy , with growth arrest and apoptosis induced in vivo in part through mitotic catastrophe . CO targeted mitochondria activity in cancer cells as evidenced by higher oxygen consumption , free radical generation , and mitochondrial collapse . Collectively , our findings indicated that CO transiently induces an anti-Warburg effect by rapidly fueling cancer cell bioenergetics , ultimately resulting in metabolic exhaustion .
    OUTPUT:

agent
resisting cell death;cellular energetics
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: One classical feature of cancer cells is their metabolic acquisition of a highly glycolytic phenotype . Carbon monoxide ( CO ) , one of the products of the cytoprotective molecule heme oxygenase-1 ( HO-1 ) in cancer cells , has been implicated in carcinogenesis and therapeutic resistance . However , the functional contributions of CO and HO-1 to these processes are poorly defined . In human prostate cancers , we found that HO-1 was nuclear localized in malignant cells , with low enzymatic activity in moderately differentiated tumors correlating with relatively worse clinical outcomes . Exposure to CO sensitized prostate cancer cells but not normal cells to chemotherapy , with growth arrest and apoptosis induced in vivo in part through mitotic catastrophe . CO targeted mitochondria activity in cancer cells as evidenced by higher oxygen consumption , free radical generation , and mitochondrial collapse . Collectively , our findings indicated that CO transiently induces an anti-Warburg effect by rapidly fueling cancer cell bioenergetics , ultimately resulting in metabolic exhaustion .
    OUTPUT:
