human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The functional and therapeutic importance of the Warburg effect is increasingly recognized , and glycolysis has become a target of anticancer strategies . We recently reported the identification of a group of novel small compounds that inhibit basal glucose transport and reduce cancer cell growth by a glucose deprivation-like mechanism . We hypothesized that the compounds target Glut1 and are efficacious in vivo as anticancer agents . Here , we report that a novel representative compound WZB117 not only inhibited cell growth in cancer cell lines but also inhibited cancer growth in a nude mouse model . Daily intraperitoneal injection of WZB117 at 10 mg/kg resulted in a more than 70% reduction in the size of human lung cancer of A549 cell origin . Mechanism studies showed that WZB117 inhibited glucose transport in human red blood cells ( RBC ) , which express Glut1 as their sole glucose transporter . Cancer cell treatment with WZB117 led to decreases in levels of Glut1 protein , intracellular ATP , and glycolytic enzymes . All these changes were followed by increase in ATP-sensing enzyme AMP-activated protein kinase ( AMPK ) and declines in cyclin E2 as well as phosphorylated retinoblastoma , resulting in cell-cycle arrest , senescence , and necrosis . Addition of extracellular ATP rescued compound-treated cancer cells , suggesting that the reduction of intracellular ATP plays an important role in the anticancer mechanism of the molecule . Senescence induction and the essential role of ATP were reported for the first time in Glut1 inhibitor-treated cancer cells . Thus , WZB117 is a prototype for further development of anticancer therapeutics targeting Glut1-mediated glucose transport and glucose metabolism .
    OUTPUT:

agent
cellular energetics;enabling replicative immortality;resisting cell death;sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The functional and therapeutic importance of the Warburg effect is increasingly recognized , and glycolysis has become a target of anticancer strategies . We recently reported the identification of a group of novel small compounds that inhibit basal glucose transport and reduce cancer cell growth by a glucose deprivation-like mechanism . We hypothesized that the compounds target Glut1 and are efficacious in vivo as anticancer agents . Here , we report that a novel representative compound WZB117 not only inhibited cell growth in cancer cell lines but also inhibited cancer growth in a nude mouse model . Daily intraperitoneal injection of WZB117 at 10 mg/kg resulted in a more than 70% reduction in the size of human lung cancer of A549 cell origin . Mechanism studies showed that WZB117 inhibited glucose transport in human red blood cells ( RBC ) , which express Glut1 as their sole glucose transporter . Cancer cell treatment with WZB117 led to decreases in levels of Glut1 protein , intracellular ATP , and glycolytic enzymes . All these changes were followed by increase in ATP-sensing enzyme AMP-activated protein kinase ( AMPK ) and declines in cyclin E2 as well as phosphorylated retinoblastoma , resulting in cell-cycle arrest , senescence , and necrosis . Addition of extracellular ATP rescued compound-treated cancer cells , suggesting that the reduction of intracellular ATP plays an important role in the anticancer mechanism of the molecule . Senescence induction and the essential role of ATP were reported for the first time in Glut1 inhibitor-treated cancer cells . Thus , WZB117 is a prototype for further development of anticancer therapeutics targeting Glut1-mediated glucose transport and glucose metabolism .
    OUTPUT:
