human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE Angiogenesis represents a key element in the pathogenesis of malignancy . There are no robust data on prognostic factors for overall survival ( OS ) in patients with metastatic colorectal cancer treated with vascular endothelial growth factor ( VEGF)-targeted therapy . The present study was conducted to establish a prognostic model for patients using an oxaliplatin-based or irinotecan-based chemotherapy plus bevacizumab in metastatic colorectal cancer . METHODS Baseline characteristics and outcomes on 170 patients treated with FOLFIRI or XELOX plus anti-VEGF therapy-naive metastatic colorectal cancer were collected from three Turkey cancer centers . Cox proportional hazards regression was used to identify independent prognostic factors for OS . RESULTS The median OS for the whole cohort was 19 months ( 95% CI , 14.3 to 23.6 months ) . Three of the seven adverse prognostic factors according to the Anatolian Society of Medical Oncology ( ASMO ) were independent predictors of short survival : serum lactate dehydrogenase ( LDH ) greater than the upper limit of normal ( ULN ; p&lt;0.001 ) ; neutrophils greater than the ULN ( p&lt;0.0014 ) ; and progression free survival ( PFS ) less than 6 months ( p =0.001 ) . CONCLUSION Serum LDH and neutrophil levels were the main prognostic factors in predicting survival , followed by PFS . This model validates incorporation of components of the ASMO model into patient care and clinical trials that use VEGF-targeting agents .
    OUTPUT:

agent
inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE Angiogenesis represents a key element in the pathogenesis of malignancy . There are no robust data on prognostic factors for overall survival ( OS ) in patients with metastatic colorectal cancer treated with vascular endothelial growth factor ( VEGF)-targeted therapy . The present study was conducted to establish a prognostic model for patients using an oxaliplatin-based or irinotecan-based chemotherapy plus bevacizumab in metastatic colorectal cancer . METHODS Baseline characteristics and outcomes on 170 patients treated with FOLFIRI or XELOX plus anti-VEGF therapy-naive metastatic colorectal cancer were collected from three Turkey cancer centers . Cox proportional hazards regression was used to identify independent prognostic factors for OS . RESULTS The median OS for the whole cohort was 19 months ( 95% CI , 14.3 to 23.6 months ) . Three of the seven adverse prognostic factors according to the Anatolian Society of Medical Oncology ( ASMO ) were independent predictors of short survival : serum lactate dehydrogenase ( LDH ) greater than the upper limit of normal ( ULN ; p&lt;0.001 ) ; neutrophils greater than the ULN ( p&lt;0.0014 ) ; and progression free survival ( PFS ) less than 6 months ( p =0.001 ) . CONCLUSION Serum LDH and neutrophil levels were the main prognostic factors in predicting survival , followed by PFS . This model validates incorporation of components of the ASMO model into patient care and clinical trials that use VEGF-targeting agents .
    OUTPUT:
