human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: A rat colonic adenocarcinoma was implanted subcutaneously ( s.c. ) in nude mice . After 7 days , the animals were divided into different groups . Two groups received subcutaneous injections twice daily with 3 or 6 micro g/kg body weight octreotide , galanin and serotonin . Three groups were respectively treated with 20 , 30 , and 40 micro g/kg body weight of the previously mentioned bioactive substances . Control group received only saline solution in the same fashion as treated animals . The treatment lasted for 5 days . The tumour volume and weight , the relative density of blood vessels , of tumour necrotic tissue , of apoptotic nuclei and of proliferating nuclei were measured . Apoptosis was detected by in situ labelling of nuclear DNA fragmentation according to TUNEL method , and proliferation by immunocytochemistry . Morphometry was done with the classical stereological point-counting method . Food consumption , animal weight , faeces weight and its water content were measured for 3 days before and after treatment . Triple therapy with 3 and 6 micro g/kg body weight had no effect on any of the parameters measured , except in reducing the relative volume density of tumour blood vessels . Treatment with 20 , 30 and 40 micro g/kg body weight of the previously mentioned bioactive substances reduced the tumour volume , the relative volume density of blood vessels and increased the relative volume density of necrotic tissue and of apoptotic nuclei ( in the 20 micro g group ) . However , there was no difference between treated mice and controls regarding the relative volume density of proliferating nuclei . There was no statistical difference between treated animals regarding food consumption , body weight , faeces weight and its water content before and during treatment . The present study confirms that triple therapy with octreotide , galanin and serotonin causes regression of a rat colon carcinoma . It further showed that optimum treatment dose is 20 micro g/kg body weight of each bioactive substance . Moreover , this therapy regime does not show apparent side effects in the experiments carried out on mice .
    OUTPUT:

agent
resisting cell death;inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: A rat colonic adenocarcinoma was implanted subcutaneously ( s.c. ) in nude mice . After 7 days , the animals were divided into different groups . Two groups received subcutaneous injections twice daily with 3 or 6 micro g/kg body weight octreotide , galanin and serotonin . Three groups were respectively treated with 20 , 30 , and 40 micro g/kg body weight of the previously mentioned bioactive substances . Control group received only saline solution in the same fashion as treated animals . The treatment lasted for 5 days . The tumour volume and weight , the relative density of blood vessels , of tumour necrotic tissue , of apoptotic nuclei and of proliferating nuclei were measured . Apoptosis was detected by in situ labelling of nuclear DNA fragmentation according to TUNEL method , and proliferation by immunocytochemistry . Morphometry was done with the classical stereological point-counting method . Food consumption , animal weight , faeces weight and its water content were measured for 3 days before and after treatment . Triple therapy with 3 and 6 micro g/kg body weight had no effect on any of the parameters measured , except in reducing the relative volume density of tumour blood vessels . Treatment with 20 , 30 and 40 micro g/kg body weight of the previously mentioned bioactive substances reduced the tumour volume , the relative volume density of blood vessels and increased the relative volume density of necrotic tissue and of apoptotic nuclei ( in the 20 micro g group ) . However , there was no difference between treated mice and controls regarding the relative volume density of proliferating nuclei . There was no statistical difference between treated animals regarding food consumption , body weight , faeces weight and its water content before and during treatment . The present study confirms that triple therapy with octreotide , galanin and serotonin causes regression of a rat colon carcinoma . It further showed that optimum treatment dose is 20 micro g/kg body weight of each bioactive substance . Moreover , this therapy regime does not show apparent side effects in the experiments carried out on mice .
    OUTPUT:
