human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Although contact inhibition is a fundamental process for multicellular organisms , how proliferation is inhibited at high cellular densities remains poorly characterized . Here we show that 4E-BP1 , one major repressor of cap-dependent translation , plays a critical role in density-mediated cell cycle arrest. 4E-BP1 promoter is activated and 4E-BP1 protein amount increases as cells reach confluence . Conversely , a much less marked density-dependent inhibition of cell proliferation is observed upon 4E-BP1 silencing . We further show that at high density , progression through the Gâ phase of the cell cycle is faster and Cyclin D1 protein is induced in different cell types where 4E-BP1 has been either downregulated ( stable shRNA expression or transient siRNA transfection ) or removed ( knock-out ) . Thus 4E-BP1 appears as an important mediator of contact inhibition .
    OUTPUT:

agent
sustaining proliferative signaling;evading growth suppressors
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Although contact inhibition is a fundamental process for multicellular organisms , how proliferation is inhibited at high cellular densities remains poorly characterized . Here we show that 4E-BP1 , one major repressor of cap-dependent translation , plays a critical role in density-mediated cell cycle arrest. 4E-BP1 promoter is activated and 4E-BP1 protein amount increases as cells reach confluence . Conversely , a much less marked density-dependent inhibition of cell proliferation is observed upon 4E-BP1 silencing . We further show that at high density , progression through the Gâ phase of the cell cycle is faster and Cyclin D1 protein is induced in different cell types where 4E-BP1 has been either downregulated ( stable shRNA expression or transient siRNA transfection ) or removed ( knock-out ) . Thus 4E-BP1 appears as an important mediator of contact inhibition .
    OUTPUT:
