human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: It is well known that ErbB2 , a receptor tyrosine kinase , localizes to the plasma membrane . Here we describe a novel observation that ErbB2 also localizes in mitochondria of cancer cells and patient samples . We found that ErbB2 translocates into mitochondria through association with mtHSP70 . Additionally , mitochondrial ErbB2 ( mtErbB2 ) negatively regulates mitochondrial respiratory functions . Oxygen consumption and activities of complexes of the mitochondrial electron transport chain were decreased in mtErbB2-overexpressing cells . Mitochondrial membrane potential and cellular ATP levels were also decreased . In contrast , mtErbB2 enhanced cellular glycolysis . The translocation of ErbB2 and its impact on mitochondrial function are kinase dependent . Interestingly , cancer cells with higher levels of mtErbB2 were more resistant to the ErbB2-targeting antibody trastuzumab . Our study provides a novel perspective on the metabolic regulatory function of ErbB2 and reveals that mtErbB2 has an important role in the regulation of cellular metabolism and cancer cell resistance to therapeutics .
    OUTPUT:

agent
cellular energetics
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: It is well known that ErbB2 , a receptor tyrosine kinase , localizes to the plasma membrane . Here we describe a novel observation that ErbB2 also localizes in mitochondria of cancer cells and patient samples . We found that ErbB2 translocates into mitochondria through association with mtHSP70 . Additionally , mitochondrial ErbB2 ( mtErbB2 ) negatively regulates mitochondrial respiratory functions . Oxygen consumption and activities of complexes of the mitochondrial electron transport chain were decreased in mtErbB2-overexpressing cells . Mitochondrial membrane potential and cellular ATP levels were also decreased . In contrast , mtErbB2 enhanced cellular glycolysis . The translocation of ErbB2 and its impact on mitochondrial function are kinase dependent . Interestingly , cancer cells with higher levels of mtErbB2 were more resistant to the ErbB2-targeting antibody trastuzumab . Our study provides a novel perspective on the metabolic regulatory function of ErbB2 and reveals that mtErbB2 has an important role in the regulation of cellular metabolism and cancer cell resistance to therapeutics .
    OUTPUT:
