human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Indolylmaleimides display a broad spectrum of biological activity and offer great opportunity to influence several aspects of cell fate , as proliferation and differentiation . In this study we describe the effect of PDA-66 , a newly synthesised indolylmaleimide , showing a strong dose dependent anti-proliferative effect on immortalised human progenitor and cancer cells . We demonstrated a highly depolymerizing effect on in vitro tubulin assembly and conclude that PDA-66 acts as microtubule destabilising agent . In addition we found that PDA-66 induces mitotic arrest of cells in the G(2)/M phase of the cell cycle . Subsequently cells undergo apoptosis , indicating the major mechanism of the anti-proliferative effect . To prove a potential anti-cancer activity of PDA-66 we examined the effect of PDA-66 on human SH-SY5Y neuroblastoma and A-459 lung cancer cells , showing a significant reduction in cancer cell proliferation in a dose dependent manner . Thus PDA-66 is a new anti-mitotic compound with an indole-core with the potential to be used for cancer therapy .
    OUTPUT:

agent
evading growth suppressors;sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Indolylmaleimides display a broad spectrum of biological activity and offer great opportunity to influence several aspects of cell fate , as proliferation and differentiation . In this study we describe the effect of PDA-66 , a newly synthesised indolylmaleimide , showing a strong dose dependent anti-proliferative effect on immortalised human progenitor and cancer cells . We demonstrated a highly depolymerizing effect on in vitro tubulin assembly and conclude that PDA-66 acts as microtubule destabilising agent . In addition we found that PDA-66 induces mitotic arrest of cells in the G(2)/M phase of the cell cycle . Subsequently cells undergo apoptosis , indicating the major mechanism of the anti-proliferative effect . To prove a potential anti-cancer activity of PDA-66 we examined the effect of PDA-66 on human SH-SY5Y neuroblastoma and A-459 lung cancer cells , showing a significant reduction in cancer cell proliferation in a dose dependent manner . Thus PDA-66 is a new anti-mitotic compound with an indole-core with the potential to be used for cancer therapy .
    OUTPUT:
