human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The mechanisms by which tumour cells metastasize and the role that cell polarity proteins play in this process are not well understood . We report that partitioning defective protein 3 ( Par3 ) is dysregulated in metastasis in human breast cancer , and is associated with a higher tumour grade and ErbB2-positive status . Downregulation of Par3 cooperated with ErbB2 to induce cell invasion and metastasis in vivo . Interestingly , the metastatic behaviour was not associated with an overt mesenchymal phenotype . However , loss of Par3 inhibited E-cadherin junction stability , disrupted membrane and actin dynamics at cell-cell junctions and decreased cell-cell cohesion in a manner dependent on the Tiam1/Rac-GTP pathway . Inhibition of this pathway restored E-cadherin junction stability and blocked invasive behaviour of cells lacking Par3 , suggesting that loss of Par3 promotes metastatic behaviour of ErbB2-induced tumour epithelial cells by decreasing cell-cell cohesion .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The mechanisms by which tumour cells metastasize and the role that cell polarity proteins play in this process are not well understood . We report that partitioning defective protein 3 ( Par3 ) is dysregulated in metastasis in human breast cancer , and is associated with a higher tumour grade and ErbB2-positive status . Downregulation of Par3 cooperated with ErbB2 to induce cell invasion and metastasis in vivo . Interestingly , the metastatic behaviour was not associated with an overt mesenchymal phenotype . However , loss of Par3 inhibited E-cadherin junction stability , disrupted membrane and actin dynamics at cell-cell junctions and decreased cell-cell cohesion in a manner dependent on the Tiam1/Rac-GTP pathway . Inhibition of this pathway restored E-cadherin junction stability and blocked invasive behaviour of cells lacking Par3 , suggesting that loss of Par3 promotes metastatic behaviour of ErbB2-induced tumour epithelial cells by decreasing cell-cell cohesion .
    OUTPUT:
