human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The number of renal cancers has increased over the last ten years and patient survival in advanced stages remains very poor . Therefore , new therapeutic approaches for renal cancer are essential . Englerin A is a natural product with a very potent and selective cytotoxicity against renal cancer cells . This makes it a promising drug candidate that may improve current treatment standards for patients with renal cancers in all stages . However , little is known about englerin A's mode of action in targeting specifically renal cancer cells . Our study is the first to investigate the biological mechanism of englerin A action in detail . We report that englerin A is specific for renal tumor cells and does not affect normal kidney cells . We find that englerin A treatment induces necrotic cell death in renal cancer cells but not in normal kidney cells . We further show that autophagic and pyroptotic proteins are unaffected by the compound and that necrotic signaling in these cells coincided with production of reactive oxygen species and calcium influx into the cytoplasm . As the first study to analyze the biological effects of englerin A , our work provides an important basis for the evaluation and validation of the compound's use as an anti-tumor drug . It also provides a context in which to identify the specific target or targets of englerin A in renal cancer cells .
    OUTPUT:

agent
resisting cell death;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The number of renal cancers has increased over the last ten years and patient survival in advanced stages remains very poor . Therefore , new therapeutic approaches for renal cancer are essential . Englerin A is a natural product with a very potent and selective cytotoxicity against renal cancer cells . This makes it a promising drug candidate that may improve current treatment standards for patients with renal cancers in all stages . However , little is known about englerin A's mode of action in targeting specifically renal cancer cells . Our study is the first to investigate the biological mechanism of englerin A action in detail . We report that englerin A is specific for renal tumor cells and does not affect normal kidney cells . We find that englerin A treatment induces necrotic cell death in renal cancer cells but not in normal kidney cells . We further show that autophagic and pyroptotic proteins are unaffected by the compound and that necrotic signaling in these cells coincided with production of reactive oxygen species and calcium influx into the cytoplasm . As the first study to analyze the biological effects of englerin A , our work provides an important basis for the evaluation and validation of the compound's use as an anti-tumor drug . It also provides a context in which to identify the specific target or targets of englerin A in renal cancer cells .
    OUTPUT:
