human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: It has been demonstrated that growth factors produced by breast cancer cells stimulate aromatase expression in both breast cancer and adjacent adipose fibroblasts and stromal cells . However , whether these growth factors affect aromatase activity by other mechanisms still remain unclear . In the current study , MCF-7aro and T47Daro aromatase transfected breast carcinoma cells were used to explore the mechanisms of post-transcriptional regulation of aromatase activity by growth factor pathways . Our study reveals that PI3K/Akt and MAPK inhibitors suppressed aromatase activity in MCF-7aro cells . However , PI3K/Akt pathway inhibitors stimulated aromatase activity in T47Daro cells . This is due to enhanced MAPK phosphorylation as compensation after the PI3K/Akt pathway has been blocked . IGF-1 treatment increased aromatase activity in both breast cancer cell lines . In addition , LTEDaro cells ( long-term estrogen deprived MCF-7aro cells ) which have enhanced MAPK activity , show higher aromatase activity compared to parental MCF-7aro cells , but the aromatase protein level remains the same . These results suggest that aromatase activity could be enhanced by growth factor signaling pathways via post-transcriptional mechanisms .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: It has been demonstrated that growth factors produced by breast cancer cells stimulate aromatase expression in both breast cancer and adjacent adipose fibroblasts and stromal cells . However , whether these growth factors affect aromatase activity by other mechanisms still remain unclear . In the current study , MCF-7aro and T47Daro aromatase transfected breast carcinoma cells were used to explore the mechanisms of post-transcriptional regulation of aromatase activity by growth factor pathways . Our study reveals that PI3K/Akt and MAPK inhibitors suppressed aromatase activity in MCF-7aro cells . However , PI3K/Akt pathway inhibitors stimulated aromatase activity in T47Daro cells . This is due to enhanced MAPK phosphorylation as compensation after the PI3K/Akt pathway has been blocked . IGF-1 treatment increased aromatase activity in both breast cancer cell lines . In addition , LTEDaro cells ( long-term estrogen deprived MCF-7aro cells ) which have enhanced MAPK activity , show higher aromatase activity compared to parental MCF-7aro cells , but the aromatase protein level remains the same . These results suggest that aromatase activity could be enhanced by growth factor signaling pathways via post-transcriptional mechanisms .
    OUTPUT:
