human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Oral squamous cell carcinoma ( OSCC ) is the most common malignant tumor in the oral and maxillofacial region . The mechanism of carcinogenesis of OSCC is still unclear . Based on the previous cell line , HIOEC-B(a)P-96 ( HB96 ) , which we obtained by HPV16 E6/E7-immortalized human oral epithelial cells ( HIOEC ) and benzo(a)pyrene inducement , we prepared a new HB-second generation cancer cell line ( HB-2 ) by continuous passage . Its characteristics such as morphology , proliferation activity , karyotype , and tumorigenesis were studied . The HB-2 cells displayed uncontrolled cell division and lost contact inhibition leading to cell overlap . Cells were polygonal and unevenly shaped , with an increased nucleus versus plasma ratio . Increased proliferative activity was confirmed by MTT assays . The tumorigenicity was confirmed by tumor growth experiments in nude mice . Therefore , the HB-2 and HB96 cell lines are useful tools to study the mechanism of carcinogenesis of OSCC in vitro for future genomic and proteomic analyses .
    OUTPUT:

agent
evading growth suppressors
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Oral squamous cell carcinoma ( OSCC ) is the most common malignant tumor in the oral and maxillofacial region . The mechanism of carcinogenesis of OSCC is still unclear . Based on the previous cell line , HIOEC-B(a)P-96 ( HB96 ) , which we obtained by HPV16 E6/E7-immortalized human oral epithelial cells ( HIOEC ) and benzo(a)pyrene inducement , we prepared a new HB-second generation cancer cell line ( HB-2 ) by continuous passage . Its characteristics such as morphology , proliferation activity , karyotype , and tumorigenesis were studied . The HB-2 cells displayed uncontrolled cell division and lost contact inhibition leading to cell overlap . Cells were polygonal and unevenly shaped , with an increased nucleus versus plasma ratio . Increased proliferative activity was confirmed by MTT assays . The tumorigenicity was confirmed by tumor growth experiments in nude mice . Therefore , the HB-2 and HB96 cell lines are useful tools to study the mechanism of carcinogenesis of OSCC in vitro for future genomic and proteomic analyses .
    OUTPUT:
