human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Depleted uranium ( DU ) is commonly used in military armor and munitions , and thus , exposure of soldiers and noncombatants is frequent and widespread . Previous studies have shown that DU has both chemical and radiological toxicity and that the primary route of exposure of DU to humans is through inhalation and ingestion . However , there is limited research information on the potential carcinogenicity of DU in human bronchial cells . Accordingly , we determined the neoplastic transforming ability of particulate DU to human bronchial epithelial cells ( BEP2D ) . We observed the loss of contact inhibition and anchorage independent growth in cells exposed to DU after 24 h . We also characterized these DU-induced transformed cell lines and found that 40% of the cell lines exhibit alterations in plating efficiency and no significant changes in the cytotoxic response to DU . Cytogenetic analyses showed that 53% of the DU-transformed cell lines possess a hypodiploid phenotype . These data indicate that human bronchial cells are transformed by DU and exhibit significant chromosome instability consistent with a neoplastic phenotype .
    OUTPUT:

agent
evading growth suppressors
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Depleted uranium ( DU ) is commonly used in military armor and munitions , and thus , exposure of soldiers and noncombatants is frequent and widespread . Previous studies have shown that DU has both chemical and radiological toxicity and that the primary route of exposure of DU to humans is through inhalation and ingestion . However , there is limited research information on the potential carcinogenicity of DU in human bronchial cells . Accordingly , we determined the neoplastic transforming ability of particulate DU to human bronchial epithelial cells ( BEP2D ) . We observed the loss of contact inhibition and anchorage independent growth in cells exposed to DU after 24 h . We also characterized these DU-induced transformed cell lines and found that 40% of the cell lines exhibit alterations in plating efficiency and no significant changes in the cytotoxic response to DU . Cytogenetic analyses showed that 53% of the DU-transformed cell lines possess a hypodiploid phenotype . These data indicate that human bronchial cells are transformed by DU and exhibit significant chromosome instability consistent with a neoplastic phenotype .
    OUTPUT:
