human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: IL-15 is a pluripotent antiapoptotic cytokine that signals to cells of both the innate and adaptive immune system and is regarded as a highly promising immunomodulatory agent in cancer therapy . Sepsis is a lethal condition in which apoptosis-induced depletion of immune cells and subsequent immunosuppression are thought to contribute to morbidity and mortality . This study tested the ability of IL-15 to block apoptosis , prevent immunosuppression , and improve survival in sepsis . Mice were made septic using cecal ligation and puncture or Pseudomonas aeruginosa pneumonia . The experiments comprised a 2 x 2 full factorial design with surgical sepsis versus sham and IL-15 versus vehicle . In addition to survival studies , splenic cellularity , canonical markers of activation and proliferation , intracellular pro- and antiapoptotic Bcl-2 family protein expression , and markers of immune cell apoptosis were evaluated by flow cytometry . Cytokine production was examined both in plasma of treated mice and splenocytes that were stimulated ex vivo . IL-15 blocked sepsis-induced apoptosis of NK cells , dendritic cells , and CD8 T cells . IL-15 also decreased sepsis-induced gut epithelial apoptosis . IL-15 therapy increased the abundance of antiapoptotic Bcl-2 while decreasing proapoptotic Bim and PUMA . IL-15 increased both circulating IFN-gamma , as well as the percentage of NK cells that produced IFN-gamma . Finally , IL-15 increased survival in both cecal ligation and puncture and P. aeruginosa pneumonia . In conclusion , IL-15 prevents two immunopathologic hallmarks of sepsis , namely , apoptosis and immunosuppression , and improves survival in two different models of sepsis . IL-15 represents a potentially novel therapy of this highly lethal disorder .
    OUTPUT:

agent
resisting cell death;avoiding immune destruction
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: IL-15 is a pluripotent antiapoptotic cytokine that signals to cells of both the innate and adaptive immune system and is regarded as a highly promising immunomodulatory agent in cancer therapy . Sepsis is a lethal condition in which apoptosis-induced depletion of immune cells and subsequent immunosuppression are thought to contribute to morbidity and mortality . This study tested the ability of IL-15 to block apoptosis , prevent immunosuppression , and improve survival in sepsis . Mice were made septic using cecal ligation and puncture or Pseudomonas aeruginosa pneumonia . The experiments comprised a 2 x 2 full factorial design with surgical sepsis versus sham and IL-15 versus vehicle . In addition to survival studies , splenic cellularity , canonical markers of activation and proliferation , intracellular pro- and antiapoptotic Bcl-2 family protein expression , and markers of immune cell apoptosis were evaluated by flow cytometry . Cytokine production was examined both in plasma of treated mice and splenocytes that were stimulated ex vivo . IL-15 blocked sepsis-induced apoptosis of NK cells , dendritic cells , and CD8 T cells . IL-15 also decreased sepsis-induced gut epithelial apoptosis . IL-15 therapy increased the abundance of antiapoptotic Bcl-2 while decreasing proapoptotic Bim and PUMA . IL-15 increased both circulating IFN-gamma , as well as the percentage of NK cells that produced IFN-gamma . Finally , IL-15 increased survival in both cecal ligation and puncture and P. aeruginosa pneumonia . In conclusion , IL-15 prevents two immunopathologic hallmarks of sepsis , namely , apoptosis and immunosuppression , and improves survival in two different models of sepsis . IL-15 represents a potentially novel therapy of this highly lethal disorder .
    OUTPUT:
