human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Family with sequence similarity 189 , member B ( FAM189B ) , alias COTE1 , a putative oncogene selected by microarray , for the first time was here found to be significantly up-regulated in hepatocellular carcinoma ( HCC ) specimens and HCC cell lines. mRNA expression of COTE1 in HCC samples and cell lines was detected by reverse transcription-polymerase chain reaction ( RT-PCR ) and real-time PCR , while protein expression of COTE1 in HCC tissues was assessed by immunohistochemistry . In addition , invasion of HCC cells was observed after overexpressing or silencing COTE1 . In the total of 48 paired HCC specimens , compared with the adjacent non-cancer tissues , the expression of COTE1 was up-regulated in 31 ( p&lt;0.01 ) . In HCC cell lines , COTE1 expression was significantly higher than in normal human adult liver ( p&lt;0.01 ) . Overexpression of COTE1 enhanced HCC-derived LM6 and MHCC-L cellular invasion in vitro . In contrast , COTE1 knockdown via RNAi markedly suppressed these phenotypes , as documented in LM3 and MHCC-H HCC cells . Mechanistic analyses indicated that COTE1 could physically associate with WW domain oxidoreductase ( WWOX ) , a tumor suppressor . COTE1 may be closely correlated with invasion of hepatocellular carcinoma ( HCC ) cells and thus may serve as an effective target for gene therapy .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Family with sequence similarity 189 , member B ( FAM189B ) , alias COTE1 , a putative oncogene selected by microarray , for the first time was here found to be significantly up-regulated in hepatocellular carcinoma ( HCC ) specimens and HCC cell lines. mRNA expression of COTE1 in HCC samples and cell lines was detected by reverse transcription-polymerase chain reaction ( RT-PCR ) and real-time PCR , while protein expression of COTE1 in HCC tissues was assessed by immunohistochemistry . In addition , invasion of HCC cells was observed after overexpressing or silencing COTE1 . In the total of 48 paired HCC specimens , compared with the adjacent non-cancer tissues , the expression of COTE1 was up-regulated in 31 ( p&lt;0.01 ) . In HCC cell lines , COTE1 expression was significantly higher than in normal human adult liver ( p&lt;0.01 ) . Overexpression of COTE1 enhanced HCC-derived LM6 and MHCC-L cellular invasion in vitro . In contrast , COTE1 knockdown via RNAi markedly suppressed these phenotypes , as documented in LM3 and MHCC-H HCC cells . Mechanistic analyses indicated that COTE1 could physically associate with WW domain oxidoreductase ( WWOX ) , a tumor suppressor . COTE1 may be closely correlated with invasion of hepatocellular carcinoma ( HCC ) cells and thus may serve as an effective target for gene therapy .
    OUTPUT:
