human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Cancer cells require glucose to support their rapid growth through a process known as aerobic glycolysis , or the Warburg effect . As in ovarian cancer cells , increased metabolic activity and glucose concentration has been linked to aggressiveness of cancer . However , it is unclear as to whether targeting the glycolytic pathway may kill the malignant cells and likely have broad therapeutic implications against ovarian cancer metastasis . In the present research , we found that EF24 , a HIF-1α inhibitor , could significantly block glucose uptake , the rate of glycolysis , and lactate production compared with vehicle treatment in SKOV-3 , A2780 and OVCAR-3 cells . These results might possibly contribute to the further observation that EF24 could inhibit ovarian cancer cell migration and invasion from wound healing and Transwell assays . Furthermore , as an important mediator of glucose metabolism , glucose transporter 1 ( Glut1 ) was found to contribute to the function of EF24 in both energy metabolism and metastasis . To examine the effect of EF24 and the mediated role of Glut1 in vivo in a xenograph subcutaneous tumor model , intraperitoneal metastasis and lung metastasis model were introduced . Our results indicated that EF24 treatment could inhibit tumor growth , intraperitoneal metastasis and lung metastasis of SKOV-3 cells , and Glut1 is a possible mediator for the role of EF24 . In conclusion , our results highlight that an anti-cancer reagent with an inhibiting effect on energy metabolism could inhibit metastasis , and EF24 is a possible candidate for anti-metastasis therapeutic applications for ovarian cancer .
    OUTPUT:

agent
cellular energetics;activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Cancer cells require glucose to support their rapid growth through a process known as aerobic glycolysis , or the Warburg effect . As in ovarian cancer cells , increased metabolic activity and glucose concentration has been linked to aggressiveness of cancer . However , it is unclear as to whether targeting the glycolytic pathway may kill the malignant cells and likely have broad therapeutic implications against ovarian cancer metastasis . In the present research , we found that EF24 , a HIF-1α inhibitor , could significantly block glucose uptake , the rate of glycolysis , and lactate production compared with vehicle treatment in SKOV-3 , A2780 and OVCAR-3 cells . These results might possibly contribute to the further observation that EF24 could inhibit ovarian cancer cell migration and invasion from wound healing and Transwell assays . Furthermore , as an important mediator of glucose metabolism , glucose transporter 1 ( Glut1 ) was found to contribute to the function of EF24 in both energy metabolism and metastasis . To examine the effect of EF24 and the mediated role of Glut1 in vivo in a xenograph subcutaneous tumor model , intraperitoneal metastasis and lung metastasis model were introduced . Our results indicated that EF24 treatment could inhibit tumor growth , intraperitoneal metastasis and lung metastasis of SKOV-3 cells , and Glut1 is a possible mediator for the role of EF24 . In conclusion , our results highlight that an anti-cancer reagent with an inhibiting effect on energy metabolism could inhibit metastasis , and EF24 is a possible candidate for anti-metastasis therapeutic applications for ovarian cancer .
    OUTPUT:
