human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Thrombopoietin ( TPO ) receptor agonists represent a new approach for the treatment of thrombocytopenia , which may develop as a consequence of immune thrombocytopenia , chemotherapy treatment , chronic hepatitis C infection , or myelodysplastic syndromes . There are concerns that use of certain growth factors can hasten disease progression in some types of hematologic malignancies and solid tumors . In this study , expression of MPL ( TPO-R ) mRNA was examined in tumor cell lines , patient tumor samples ( renal cell carcinoma , prostatic carcinoma , soft tissue and bony/cartilage sarcoma , colon cancer , and lymphoma ) , and normal tissues using microarray analysis and qRT-PCR . MPL mRNA is expressed at very low or undetectable levels compared with erythropoietin receptor ( EPOR ) , human epidermal growth factor ( ERBB2 ; HER2 ) , and insulin-like growth factor-1 receptor ( IGF1R ) in these patient samples . These data suggest TPO-R agonists will likely preferentially stimulate proliferation and differentiation of cells of megakaryocytic lineage , potentially demonstrating their utility for correcting thrombocytopenia in clinical settings .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Thrombopoietin ( TPO ) receptor agonists represent a new approach for the treatment of thrombocytopenia , which may develop as a consequence of immune thrombocytopenia , chemotherapy treatment , chronic hepatitis C infection , or myelodysplastic syndromes . There are concerns that use of certain growth factors can hasten disease progression in some types of hematologic malignancies and solid tumors . In this study , expression of MPL ( TPO-R ) mRNA was examined in tumor cell lines , patient tumor samples ( renal cell carcinoma , prostatic carcinoma , soft tissue and bony/cartilage sarcoma , colon cancer , and lymphoma ) , and normal tissues using microarray analysis and qRT-PCR . MPL mRNA is expressed at very low or undetectable levels compared with erythropoietin receptor ( EPOR ) , human epidermal growth factor ( ERBB2 ; HER2 ) , and insulin-like growth factor-1 receptor ( IGF1R ) in these patient samples . These data suggest TPO-R agonists will likely preferentially stimulate proliferation and differentiation of cells of megakaryocytic lineage , potentially demonstrating their utility for correcting thrombocytopenia in clinical settings .
    OUTPUT:
