human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Metastatic cancer cells typically fail to halt migration on contact with non-cancer cells . This invasiveness is in contrast to normal mesenchymal cells that retract on contact with another cell . Why cancer cells are defective in contact inhibition of locomotion is not understood . Here , we analyse the dynamics of prostate cancer cell lines co-cultured with fibroblasts , and demonstrate that a combinatorial code of Eph receptor activation dictates whether cell migration will be contact inhibited . The unimpeded migration of metastatic PC-3 cells towards fibroblasts is dependent on activation of EphB3 and EphB4 by ephrin-B2 , which we show activates Cdc42 and cell migration . Knockdown of EphB3 and EphB4 restores contact inhibition of locomotion to PC-3 cells . Conversely , homotypic collisions between two cancer cells results in contact inhibition of locomotion , mediated by EphA-Rho-Rho kinase ( ROCK ) signalling . Thus , the migration of cancer cells can switch from restrained to invasive , depending on the Eph-receptor profile of the cancer cell and the reciprocal ephrin ligands expressed by neighbouring cells .
    OUTPUT:

agent
evading growth suppressors;activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Metastatic cancer cells typically fail to halt migration on contact with non-cancer cells . This invasiveness is in contrast to normal mesenchymal cells that retract on contact with another cell . Why cancer cells are defective in contact inhibition of locomotion is not understood . Here , we analyse the dynamics of prostate cancer cell lines co-cultured with fibroblasts , and demonstrate that a combinatorial code of Eph receptor activation dictates whether cell migration will be contact inhibited . The unimpeded migration of metastatic PC-3 cells towards fibroblasts is dependent on activation of EphB3 and EphB4 by ephrin-B2 , which we show activates Cdc42 and cell migration . Knockdown of EphB3 and EphB4 restores contact inhibition of locomotion to PC-3 cells . Conversely , homotypic collisions between two cancer cells results in contact inhibition of locomotion , mediated by EphA-Rho-Rho kinase ( ROCK ) signalling . Thus , the migration of cancer cells can switch from restrained to invasive , depending on the Eph-receptor profile of the cancer cell and the reciprocal ephrin ligands expressed by neighbouring cells .
    OUTPUT:
