human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: There are many growth factors influencing the expansion of multiple myeloma ( MM ) . Angiogenesis is a process that may enhance MM growth , in various manners . Among them , insulin-like growth factor-1 ( IGF-1 ) is a major factor , acting in many levels . The aim of the study was to measure serum levels of IGF-1 in newly diagnosed MM patients and to correlate them with clinical stage of the disease and with markers of angiogenesis , such as vascular endothelial growth factor ( VEGF ) , hepatocyte growth factor ( HGF ) , and interleukin-6 and 15 ( IL-6 and IL-15 ) . Serum levels of the above factors were measured , by ELISA , in 57 newly diagnosed MM patients and in 20 healthy controls . There was no difference in serum levels of IGF-1 in MM patients and in controls , contrary to angiogenic factors , which were higher in MM patients ( p &lt ; 0.001 ) . Similarly , IGF-1 did not correlate with clinical stage of the disease nor the other angiogenic factors , which also correlated with each other ( p &lt ; 0.001 ) . Serum IGF-1 concentrations are not influenced in MM patients . Therefore , although it is a proliferation cytokine , it cannot be used as marker of disease activity .
    OUTPUT:

agent
inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: There are many growth factors influencing the expansion of multiple myeloma ( MM ) . Angiogenesis is a process that may enhance MM growth , in various manners . Among them , insulin-like growth factor-1 ( IGF-1 ) is a major factor , acting in many levels . The aim of the study was to measure serum levels of IGF-1 in newly diagnosed MM patients and to correlate them with clinical stage of the disease and with markers of angiogenesis , such as vascular endothelial growth factor ( VEGF ) , hepatocyte growth factor ( HGF ) , and interleukin-6 and 15 ( IL-6 and IL-15 ) . Serum levels of the above factors were measured , by ELISA , in 57 newly diagnosed MM patients and in 20 healthy controls . There was no difference in serum levels of IGF-1 in MM patients and in controls , contrary to angiogenic factors , which were higher in MM patients ( p &lt ; 0.001 ) . Similarly , IGF-1 did not correlate with clinical stage of the disease nor the other angiogenic factors , which also correlated with each other ( p &lt ; 0.001 ) . Serum IGF-1 concentrations are not influenced in MM patients . Therefore , although it is a proliferation cytokine , it cannot be used as marker of disease activity .
    OUTPUT:
