human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Hormone-dependent estrogen receptor positive ( ER+ ) breast cancers generally respond well to anti-estrogen therapy . Unfortunately , hormone-independent estrogen receptor negative ( ER- ) breast cancers are aggressive , respond poorly to current treatments and have a poor prognosis . New approaches and targets are needed for the prevention and treatment of ER- breast cancer . The NF-ÎºB signaling pathway is strongly implicated in ER- tumor genesis , constituting a possible target for treatment . Hydrogen sulfide-releasing aspirin ( HS-ASA ) , a novel and safer derivative of aspirin , has shown promise as an anti-cancer agent . We examined the growth inhibitory effect of HS-ASA via alterations in cell proliferation , cell cycle phase transitions , and apoptosis , using MDA-MB-231 cells as a model of triple negative breast cancer . Tumor xenografts in mice , representing human ER- breast cancer , were evaluated for reduction in tumor size , followed by immunohistochemical analysis for proliferation , apoptosis and expression of NF-ÎºB . HS-ASA suppressed the growth of MDA-MB-231 cells by induction of G(0)/G(1) arrest and apoptosis , down-regulation of NF-ÎºB , reduction of thioredoxin reductase activity , and increased levels reactive oxygen species . Tumor xenografts in mice , were significantly reduced in volume and mass by HS-ASA treatment . The decrease in tumor mass was associated with inhibition of cell proliferation , induction of apoptosis and decrease in NF-ÎºB levels in vivo . HS-ASA has anti-cancer potential against ER- breast cancer and merits further study .
    OUTPUT:

agent
resisting cell death;sustaining proliferative signaling;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Hormone-dependent estrogen receptor positive ( ER+ ) breast cancers generally respond well to anti-estrogen therapy . Unfortunately , hormone-independent estrogen receptor negative ( ER- ) breast cancers are aggressive , respond poorly to current treatments and have a poor prognosis . New approaches and targets are needed for the prevention and treatment of ER- breast cancer . The NF-ÎºB signaling pathway is strongly implicated in ER- tumor genesis , constituting a possible target for treatment . Hydrogen sulfide-releasing aspirin ( HS-ASA ) , a novel and safer derivative of aspirin , has shown promise as an anti-cancer agent . We examined the growth inhibitory effect of HS-ASA via alterations in cell proliferation , cell cycle phase transitions , and apoptosis , using MDA-MB-231 cells as a model of triple negative breast cancer . Tumor xenografts in mice , representing human ER- breast cancer , were evaluated for reduction in tumor size , followed by immunohistochemical analysis for proliferation , apoptosis and expression of NF-ÎºB . HS-ASA suppressed the growth of MDA-MB-231 cells by induction of G(0)/G(1) arrest and apoptosis , down-regulation of NF-ÎºB , reduction of thioredoxin reductase activity , and increased levels reactive oxygen species . Tumor xenografts in mice , were significantly reduced in volume and mass by HS-ASA treatment . The decrease in tumor mass was associated with inhibition of cell proliferation , induction of apoptosis and decrease in NF-ÎºB levels in vivo . HS-ASA has anti-cancer potential against ER- breast cancer and merits further study .
    OUTPUT:
