human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: NIH-3T3 cells are non-tumorigenic when injected into athymic mice . If these cells are mixed with an extract of basement-membrane proteins ( matrigel ) and injected s.c. , they form locally invasive and highly vascularized tumors . Cells cultured from the NIH-3T3-matrigel-induced tumors showed a transformed phenotype and lacked contact inhibition . When cultured in a gel of matrigel , they proliferated and formed branched and invasive colonies . In contrast , the parental NIH-3T3 cells cultured on matrigel remained as cell aggregates and were not invasive . I.V. injections of the tumor-derived NIH-3T3 cells produced many colonies on the surface of the lungs , whereas the parental NIH-3T3 cells were not metastatic . Zymographic analysis of the conditioned media obtained from both the tumor-derived and parental NIH-3T3 cells demonstrated higher amounts of the 72-kDa gelatinase ( type-IV collagenase ) enzyme in the tumor-derived cells . Also , tumor-derived NIH-3T3 cells , but not parental NIH-3T3 cells , secreted the 92-kDa type-IV collagenase . These studies suggest that the interaction of pre-malignant NIH-3T3 cells with extracellular matrix components may contribute to the process of tumor progression .
    OUTPUT:

agent
activating invasion and metastasis;inducing angiogenesis;evading growth suppressors
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: NIH-3T3 cells are non-tumorigenic when injected into athymic mice . If these cells are mixed with an extract of basement-membrane proteins ( matrigel ) and injected s.c. , they form locally invasive and highly vascularized tumors . Cells cultured from the NIH-3T3-matrigel-induced tumors showed a transformed phenotype and lacked contact inhibition . When cultured in a gel of matrigel , they proliferated and formed branched and invasive colonies . In contrast , the parental NIH-3T3 cells cultured on matrigel remained as cell aggregates and were not invasive . I.V. injections of the tumor-derived NIH-3T3 cells produced many colonies on the surface of the lungs , whereas the parental NIH-3T3 cells were not metastatic . Zymographic analysis of the conditioned media obtained from both the tumor-derived and parental NIH-3T3 cells demonstrated higher amounts of the 72-kDa gelatinase ( type-IV collagenase ) enzyme in the tumor-derived cells . Also , tumor-derived NIH-3T3 cells , but not parental NIH-3T3 cells , secreted the 92-kDa type-IV collagenase . These studies suggest that the interaction of pre-malignant NIH-3T3 cells with extracellular matrix components may contribute to the process of tumor progression .
    OUTPUT:
