human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: More effective treatments for metastatic lung cancer remain a pressing clinical need . In this study , we identified migration inducting gene-7 ( MIG-7 ) protein as critical for COX-2/prostaglandin E2 ( PGE2)- and Akt/GSK-3Î²-dependent tumor invasion/metastasis . COX-2/PGE2 activated EP4 to enhance Akt and GSK-3Î² phosphorylation and Î²-catenin/T-cell factor/lymphoid enhancer factor signaling leading to MIG-7 upregulation . RNAi-mediated attenuation of MIG-7 blocked COX-2/PGE2- and Akt/GSK-3Î²-mediated migration/invasion effects . Furthermore , MIG-7 protein inhibited protein phosphatase 2A to sustain Akt/GSK-3Î² phosphorylation and cancer-cell migration/invasion . Cancer cells overexpressing MIG-7 exhibited increased expression of ZEB-1 and Twist in parallel with epithelial-mesenchymal transition , metastasis and cancer lethality . MIG-7 protein level positively correlated with advanced stages of human lung cancers . MIG-7 thus offers a theranostic target for cancer metastases arising from aberrant activation of the cellular COX-2/PGE2 and Akt/GSK-3Î² signaling pathways .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: More effective treatments for metastatic lung cancer remain a pressing clinical need . In this study , we identified migration inducting gene-7 ( MIG-7 ) protein as critical for COX-2/prostaglandin E2 ( PGE2)- and Akt/GSK-3Î²-dependent tumor invasion/metastasis . COX-2/PGE2 activated EP4 to enhance Akt and GSK-3Î² phosphorylation and Î²-catenin/T-cell factor/lymphoid enhancer factor signaling leading to MIG-7 upregulation . RNAi-mediated attenuation of MIG-7 blocked COX-2/PGE2- and Akt/GSK-3Î²-mediated migration/invasion effects . Furthermore , MIG-7 protein inhibited protein phosphatase 2A to sustain Akt/GSK-3Î² phosphorylation and cancer-cell migration/invasion . Cancer cells overexpressing MIG-7 exhibited increased expression of ZEB-1 and Twist in parallel with epithelial-mesenchymal transition , metastasis and cancer lethality . MIG-7 protein level positively correlated with advanced stages of human lung cancers . MIG-7 thus offers a theranostic target for cancer metastases arising from aberrant activation of the cellular COX-2/PGE2 and Akt/GSK-3Î² signaling pathways .
    OUTPUT:
