human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: To investigate whether altered energy metabolism induces the Warburg effect and results in tumor malignancy , the respiratory enzyme citrate synthase ( CS ) was examined , silenced , and the effects analyzed . In human cervical carcinoma cells , RNAi-mediated CS knockdown induced morphological changes characteristic of the epithelial-mesenchymal transition ( EMT ) . This switch accelerated cancer cell metastasis and proliferation in in vitro assays and in vivo tumor xenograft models . Notably , CS knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production , but great increases in glycolytic metabolism . This malignant progression was due to activation of EMT-related regulators ; altered energy metabolism resulted from deregulation of the p53/TIGAR and SCO2 pathways . This phenotypic change was completely reversed by p53 reactivation via treatment with proteasome inhibitor MG132 or co-knockdown of E3 ligase HDM2 and partially suppressed by ATP treatment . This study directly links the Warburg effect to tumor malignancy via induction of the EMT phenotype .
    OUTPUT:

agent
activating invasion and metastasis;cellular energetics
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: To investigate whether altered energy metabolism induces the Warburg effect and results in tumor malignancy , the respiratory enzyme citrate synthase ( CS ) was examined , silenced , and the effects analyzed . In human cervical carcinoma cells , RNAi-mediated CS knockdown induced morphological changes characteristic of the epithelial-mesenchymal transition ( EMT ) . This switch accelerated cancer cell metastasis and proliferation in in vitro assays and in vivo tumor xenograft models . Notably , CS knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production , but great increases in glycolytic metabolism . This malignant progression was due to activation of EMT-related regulators ; altered energy metabolism resulted from deregulation of the p53/TIGAR and SCO2 pathways . This phenotypic change was completely reversed by p53 reactivation via treatment with proteasome inhibitor MG132 or co-knockdown of E3 ligase HDM2 and partially suppressed by ATP treatment . This study directly links the Warburg effect to tumor malignancy via induction of the EMT phenotype .
    OUTPUT:
