human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Anal canal cancer is a rare tumor without clear treatment evidence in the metastatic setting . In terms of the bad prognosis of patients with metastatic anal cancer , further therapeutic options are urgently needed . In this paper we present the case of a 64-year-old man suffering from undifferentiated squamous cell carcinoma with liver metastases . After progression on cisplatin and fluorouracil , tumor tissue was analyzed with respect to anti-EGFR therapy with cetuximab . There was no KRAS mutation and the EGFR expression level in the tumor tissue was 2+ ; ideal conditions for the immunotherapy . Encouraged by these results we started a therapy using FOLFIRI in combination with cetuximab . Fortunately the patient showed a partial response after 6 cycles . On patient's preference we did a therapy break of 6 weeks . Within this time period the disease was progressive indicating its aggressiveness . However , the same immunotherapy was able to stabilize the disease for a further 3 months . The patient died 21 months after diagnosis because of liver failure . Nevertheless , from our perspective the combination of FOLFIRI and cetuximab is quite a promising therapeutic option for patients with metastatic anal cancer . Potential predictive factors of the immunochemotherapy are discussed in this paper .
    OUTPUT:

agent
genomic instability and mutation;activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Anal canal cancer is a rare tumor without clear treatment evidence in the metastatic setting . In terms of the bad prognosis of patients with metastatic anal cancer , further therapeutic options are urgently needed . In this paper we present the case of a 64-year-old man suffering from undifferentiated squamous cell carcinoma with liver metastases . After progression on cisplatin and fluorouracil , tumor tissue was analyzed with respect to anti-EGFR therapy with cetuximab . There was no KRAS mutation and the EGFR expression level in the tumor tissue was 2+ ; ideal conditions for the immunotherapy . Encouraged by these results we started a therapy using FOLFIRI in combination with cetuximab . Fortunately the patient showed a partial response after 6 cycles . On patient's preference we did a therapy break of 6 weeks . Within this time period the disease was progressive indicating its aggressiveness . However , the same immunotherapy was able to stabilize the disease for a further 3 months . The patient died 21 months after diagnosis because of liver failure . Nevertheless , from our perspective the combination of FOLFIRI and cetuximab is quite a promising therapeutic option for patients with metastatic anal cancer . Potential predictive factors of the immunochemotherapy are discussed in this paper .
    OUTPUT:
