human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: To elucidate role of the three enzymes in hepatocarcinogenesis , hMTH1 , hOGG1 and hMYH , mRNA expression were examined by using RT/semi-quantitative real-time PCR and 8-O-HdG levels was studied by HPLC/ECD in HCC and non-tumorous liver tissue of 21 patients with hepatocellular carcinoma ( HCC ) . It was found that the 8-OHdG level in non-tumourous liver tissue was significantly higher than in HCC tissue ( P = 0.006 ) , and this was correlated with the degree of inflammation . The hMTH1 expression in HCC tissue was significantly higher than in non-tumorous liver tissue ( P = 0.014 ) . Inversely , The hMYH alpha expression was significantly increased ( P = 0.039 ) in non-tumorous liver tissue . No difference was seen in hOGG1 expression in non-tumorous liver and HCC tissue . A significant linear correlation between hMTH1 and hOGG1 expression was found both in HCC tissue ( r = 0.809 , P &lt ; 0.001 ) and in non-tumorous liver tissue ( r = 0.883 , P &lt ; 0.001 ) . Our findings suggested a reactive rather than pathogenic role of the DNA repair enzymes in the hepatocarcinogenesis .
    OUTPUT:

agent
genomic instability and mutation;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: To elucidate role of the three enzymes in hepatocarcinogenesis , hMTH1 , hOGG1 and hMYH , mRNA expression were examined by using RT/semi-quantitative real-time PCR and 8-O-HdG levels was studied by HPLC/ECD in HCC and non-tumorous liver tissue of 21 patients with hepatocellular carcinoma ( HCC ) . It was found that the 8-OHdG level in non-tumourous liver tissue was significantly higher than in HCC tissue ( P = 0.006 ) , and this was correlated with the degree of inflammation . The hMTH1 expression in HCC tissue was significantly higher than in non-tumorous liver tissue ( P = 0.014 ) . Inversely , The hMYH alpha expression was significantly increased ( P = 0.039 ) in non-tumorous liver tissue . No difference was seen in hOGG1 expression in non-tumorous liver and HCC tissue . A significant linear correlation between hMTH1 and hOGG1 expression was found both in HCC tissue ( r = 0.809 , P &lt ; 0.001 ) and in non-tumorous liver tissue ( r = 0.883 , P &lt ; 0.001 ) . Our findings suggested a reactive rather than pathogenic role of the DNA repair enzymes in the hepatocarcinogenesis .
    OUTPUT:
