human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Our purpose in this randomized , double blind , placebo controlled study was to find out the possible effect of a polyphenolic pine bark extract , PycnogenolÂ® ( Pyc ) on the level of 8-oxo-7,8-dihydroguanine ( 8-oxoG ) as representative of oxidative damage to DNA and on the DNA repair ability of elderly people . According to our results , three months of Pyc administration had no effect on the level of oxidative damage to DNA or on repair ability , but we found a relationship between the level of 8-oxoG and repair ability of DNA in this group . To conclude , even if the positive effect of Pyc was not confirmed in the case of elderly people it is important to highlight the necessity of further investigations about the mechanisms of Pyc acting on different age groups .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Our purpose in this randomized , double blind , placebo controlled study was to find out the possible effect of a polyphenolic pine bark extract , PycnogenolÂ® ( Pyc ) on the level of 8-oxo-7,8-dihydroguanine ( 8-oxoG ) as representative of oxidative damage to DNA and on the DNA repair ability of elderly people . According to our results , three months of Pyc administration had no effect on the level of oxidative damage to DNA or on repair ability , but we found a relationship between the level of 8-oxoG and repair ability of DNA in this group . To conclude , even if the positive effect of Pyc was not confirmed in the case of elderly people it is important to highlight the necessity of further investigations about the mechanisms of Pyc acting on different age groups .
    OUTPUT:
