human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Ultraviolet ( UV ) light induces DNA-damage checkpoints and mutagenesis , which are involved in cancer protection and tumorigenesis , respectively . How cells identify DNA lesions and convert them to checkpoint-activating structures is a major question . We show that during repair of UV lesions in noncycling cells , Exo1-mediated processing of nucleotide excision repair ( NER ) intermediates competes with repair DNA synthesis . Impediments of the refilling reaction allow Exo1 to generate extended ssDNA gaps , detectable by electron microscopy , which drive Mec1 kinase activation and will be refilled by long-patch repair synthesis , as shown by DNA combing . We provide evidence that this mechanism maybe stimulated by closely opposing UV lesions , represents a strategy to redirect problematic repair intermediates to alternative repair pathways , and may also be extended to physically different DNA damages . Our work has significant implications for understanding the coordination between repair of DNA lesions and checkpoint pathways to preserve genome stability .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Ultraviolet ( UV ) light induces DNA-damage checkpoints and mutagenesis , which are involved in cancer protection and tumorigenesis , respectively . How cells identify DNA lesions and convert them to checkpoint-activating structures is a major question . We show that during repair of UV lesions in noncycling cells , Exo1-mediated processing of nucleotide excision repair ( NER ) intermediates competes with repair DNA synthesis . Impediments of the refilling reaction allow Exo1 to generate extended ssDNA gaps , detectable by electron microscopy , which drive Mec1 kinase activation and will be refilled by long-patch repair synthesis , as shown by DNA combing . We provide evidence that this mechanism maybe stimulated by closely opposing UV lesions , represents a strategy to redirect problematic repair intermediates to alternative repair pathways , and may also be extended to physically different DNA damages . Our work has significant implications for understanding the coordination between repair of DNA lesions and checkpoint pathways to preserve genome stability .
    OUTPUT:
