human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: In this study , we compared the effects of SKI-606 with Iressa , Src/Abl and EGF-R kinase inhibitors , respectively , on selected parameters in HeLa and SiHa cervical cancer cell lines , which express E6/E7 oncoproteins of high-risk HPV types 18 and 16 , respectively . Our results show that SKI-606 and Iressa inhibit cell proliferation and provoke G(0)-G(1) cell cycle arrest and reduction of S and G(2)-M phase using 2 and 5âÎ¼M concentrations of these inhibitors . In contrast , SKI-606 induces differentiation to an epithelial phenotype " mesenchymal-epithelial transition " ; thus SKI-606 causes a dramatic decrease in cell motility and invasion abilities of HeLa and SiHa cancer cells , in comparison to untreated cells and Iressa-treated cells in which these parameters are only slightly affected . These changes are accompanied by a regulation of the expression patterns of E-cadherin and catenins . The molecular pathway analysis of Src/Abl inhibitor revealed that SKI-606 blocks the phosphorylation of Î²-catenin and consequently converts its role from a transcriptional regulator to a cell-cell adhesion molecule . Our findings indicate that SKI-606 inhibits signaling pathways involved in regulating tumor cell migration and invasion genes via Î²-catenin alteration , suggesting that Src inhibitor , in comparison to EGF-R , is a promising therapeutic agent for human cervical cancer .
    OUTPUT:

agent
evading growth suppressors;sustaining proliferative signaling;activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: In this study , we compared the effects of SKI-606 with Iressa , Src/Abl and EGF-R kinase inhibitors , respectively , on selected parameters in HeLa and SiHa cervical cancer cell lines , which express E6/E7 oncoproteins of high-risk HPV types 18 and 16 , respectively . Our results show that SKI-606 and Iressa inhibit cell proliferation and provoke G(0)-G(1) cell cycle arrest and reduction of S and G(2)-M phase using 2 and 5âÎ¼M concentrations of these inhibitors . In contrast , SKI-606 induces differentiation to an epithelial phenotype " mesenchymal-epithelial transition " ; thus SKI-606 causes a dramatic decrease in cell motility and invasion abilities of HeLa and SiHa cancer cells , in comparison to untreated cells and Iressa-treated cells in which these parameters are only slightly affected . These changes are accompanied by a regulation of the expression patterns of E-cadherin and catenins . The molecular pathway analysis of Src/Abl inhibitor revealed that SKI-606 blocks the phosphorylation of Î²-catenin and consequently converts its role from a transcriptional regulator to a cell-cell adhesion molecule . Our findings indicate that SKI-606 inhibits signaling pathways involved in regulating tumor cell migration and invasion genes via Î²-catenin alteration , suggesting that Src inhibitor , in comparison to EGF-R , is a promising therapeutic agent for human cervical cancer .
    OUTPUT:
