human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: PURPOSE Steroid hormones and growth factors affect lung cancer , and it is possible they act in concert to influence patient outcome . EXPERIMENTAL DESIGN Primary lung tumors and normal lung tissue were analyzed for expression and localization of estrogen receptor Î± and Î²-1 ( ERÎ± and ERÎ² ) , aromatase , progesterone receptor ( PR ) , and epidermal growth factor receptor ( EGFR ) . RESULTS Tumors expressed higher levels of ERÎ² compared to matched normal lung , whereas the reverse was true of PR . High cytoplasmic ERÎ² expression was identified as an independent negative prognostic predictor of overall survival ( OS ; HR = 1.67 ) , and low total PR was identified as an independent negative predictor of time to progression ( TTP ; HR = 1.59 ) . After adjusting for stage , age , sex , and smoking , combined high cytoplasmic ERÎ² and low total PR showed enhanced effects on OS ( HR = 2.64 ) and on TTP ( HR = 6.02 ) . Further effects on OS were observed when EGFR expression was included ( HR = 5.32 ) . Patients with low cytoplasmic ERÎ² , low aromatase , low EGFR , and high total PR had shorter OS than patients with the opposite pattern ( HR = 6.60 ) . Contribution of these markers to survival showed no significant sex differences in a multivariable model . ERÎ± was elevated in tumors but was not predictive of survival , and appears to represent a variant ERÎ± protein that is only recognized by a C-terminal antibody . CONCLUSIONS Hormonal and EGFR pathways together may contribute to lung cancer prognosis . Lung tumors with high ERÎ²-1/low PR may define patients with aggressive biology . A validation study is necessary to fully assess the predictive value of these markers .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: PURPOSE Steroid hormones and growth factors affect lung cancer , and it is possible they act in concert to influence patient outcome . EXPERIMENTAL DESIGN Primary lung tumors and normal lung tissue were analyzed for expression and localization of estrogen receptor Î± and Î²-1 ( ERÎ± and ERÎ² ) , aromatase , progesterone receptor ( PR ) , and epidermal growth factor receptor ( EGFR ) . RESULTS Tumors expressed higher levels of ERÎ² compared to matched normal lung , whereas the reverse was true of PR . High cytoplasmic ERÎ² expression was identified as an independent negative prognostic predictor of overall survival ( OS ; HR = 1.67 ) , and low total PR was identified as an independent negative predictor of time to progression ( TTP ; HR = 1.59 ) . After adjusting for stage , age , sex , and smoking , combined high cytoplasmic ERÎ² and low total PR showed enhanced effects on OS ( HR = 2.64 ) and on TTP ( HR = 6.02 ) . Further effects on OS were observed when EGFR expression was included ( HR = 5.32 ) . Patients with low cytoplasmic ERÎ² , low aromatase , low EGFR , and high total PR had shorter OS than patients with the opposite pattern ( HR = 6.60 ) . Contribution of these markers to survival showed no significant sex differences in a multivariable model . ERÎ± was elevated in tumors but was not predictive of survival , and appears to represent a variant ERÎ± protein that is only recognized by a C-terminal antibody . CONCLUSIONS Hormonal and EGFR pathways together may contribute to lung cancer prognosis . Lung tumors with high ERÎ²-1/low PR may define patients with aggressive biology . A validation study is necessary to fully assess the predictive value of these markers .
    OUTPUT:
