human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Cancer cells undergo multi-step processes in obtaining the ability to metastasize , and are constantly exposed to signals that induce apoptosis . Acquisition of anti-apoptotic properties by cancer cells is important for metastasis , and recent studies suggest that transforming growth factor ( TGF)-Î² promotes the survival of certain types of cancer cells . Here , we found that in highly metastatic breast cancer cells , JygMC(A) , JygMC(B) and 4T1 , TGF-Î² ligands were produced in autocrine fashion . Pharmacological inhibition of endogenous TGF-Î² signalling by a TGF-Î² type I receptor kinase inhibitor in serum-free conditions increased the expression of BH3-only protein , Bim ( also known as Bcl2-like 11 ) in JygMC(A) and JygMC(B) cells , and caused apoptotic cell death . We also found that induction of Bim by TGF-Î² was not observed in Foxc1 knocked-down cancer cells . These findings suggest that TGF-Î² plays a crucial role in the regulation of survival of certain types of cancer cells through the TGF-Î²-Foxc1-Bim pathway , and that specific inhibitors of TGF-Î² signalling might be useful as apoptosis inducers in breast cancer cells .
    OUTPUT:

agent
sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Cancer cells undergo multi-step processes in obtaining the ability to metastasize , and are constantly exposed to signals that induce apoptosis . Acquisition of anti-apoptotic properties by cancer cells is important for metastasis , and recent studies suggest that transforming growth factor ( TGF)-Î² promotes the survival of certain types of cancer cells . Here , we found that in highly metastatic breast cancer cells , JygMC(A) , JygMC(B) and 4T1 , TGF-Î² ligands were produced in autocrine fashion . Pharmacological inhibition of endogenous TGF-Î² signalling by a TGF-Î² type I receptor kinase inhibitor in serum-free conditions increased the expression of BH3-only protein , Bim ( also known as Bcl2-like 11 ) in JygMC(A) and JygMC(B) cells , and caused apoptotic cell death . We also found that induction of Bim by TGF-Î² was not observed in Foxc1 knocked-down cancer cells . These findings suggest that TGF-Î² plays a crucial role in the regulation of survival of certain types of cancer cells through the TGF-Î²-Foxc1-Bim pathway , and that specific inhibitors of TGF-Î² signalling might be useful as apoptosis inducers in breast cancer cells .
    OUTPUT:
