human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Immunosuppressive oligodeoxynucleotides ( SupODNs ) containing repetitive TTAGGG motifs reduce inflammation and , thus , may have an impact on inflammationârelated tumor growth . In this study , we found a significant antiproliferative effect of Sup ODNs on the A549 nonâsmall cell lung cancer ( NSCLC ) cell line compared to those treated with control ODNs ( p&lt;0.05 ) . Sup-ODN-mediated G1 phase cell cycle arrest was achieved via inhibition of Akt and extracellular signal-regulated kinase 1/2 phosphorylation and the p15INK4b and p27KIP1/retinoblastoma protein pathway . In addition , Sup ODNs induced apoptosis and enhanced apoptosis when combined with vinorelbine . In a setting similar to clinical use of multidrug chemotherapy for advanced NSCLC , these effects were investigated by using Sup ODNs in combination with conventional anticancer drugs . Sup ODNs had a significant synergistic effect with 5-fluorouracil , vinorelbine , gemcitabine , paclitaxel and irinotecan , with a mean combination index of 0.43-0.78 ( &lt;1.0 indicates synergism ) in the A549 NSCLC cell line . In conclusion , our results showed that Sup ODNs have an anticancer effect and increase the sensitivity of NSCLC cells to conventional anticancer drugs by modifying Akt and the extracellular signal-regulated kinase 1/2 pathway . Thus , Sup ODNs may serve as a novel therapeutic strategy for NSCLC patients .
    OUTPUT:

agent
evading growth suppressors;sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Immunosuppressive oligodeoxynucleotides ( SupODNs ) containing repetitive TTAGGG motifs reduce inflammation and , thus , may have an impact on inflammationârelated tumor growth . In this study , we found a significant antiproliferative effect of Sup ODNs on the A549 nonâsmall cell lung cancer ( NSCLC ) cell line compared to those treated with control ODNs ( p&lt;0.05 ) . Sup-ODN-mediated G1 phase cell cycle arrest was achieved via inhibition of Akt and extracellular signal-regulated kinase 1/2 phosphorylation and the p15INK4b and p27KIP1/retinoblastoma protein pathway . In addition , Sup ODNs induced apoptosis and enhanced apoptosis when combined with vinorelbine . In a setting similar to clinical use of multidrug chemotherapy for advanced NSCLC , these effects were investigated by using Sup ODNs in combination with conventional anticancer drugs . Sup ODNs had a significant synergistic effect with 5-fluorouracil , vinorelbine , gemcitabine , paclitaxel and irinotecan , with a mean combination index of 0.43-0.78 ( &lt;1.0 indicates synergism ) in the A549 NSCLC cell line . In conclusion , our results showed that Sup ODNs have an anticancer effect and increase the sensitivity of NSCLC cells to conventional anticancer drugs by modifying Akt and the extracellular signal-regulated kinase 1/2 pathway . Thus , Sup ODNs may serve as a novel therapeutic strategy for NSCLC patients .
    OUTPUT:
