human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Antithymocyte globulin is widely used before haematopoietic transplantation with HLA-matched unrelated donors or mismatched relatives to prevent rejection and graft-versus-host disease ( GVHD ) . However , optimal dosage is still under debate . Thirty-one consecutive children , mainly with haematological malignancies , were transplanted in a single institution with such donors , selected by HLA-A -B compatibility by serology and DRB1* by DNA typing . Antithymocyte globulin ( Thymoglobuline ; Sangstat ) was infused at days -3 , -2 , -1 . Total dosage varied : 16 patients received a median of 7.5 mg/kg ( 2.5 to 10.5 : low-dose group ) , and 15 a median of 15.5 mg/kg ( 14.4 to 19.4 : high-dose group ) . Post-transplant GVHD prophylaxis consisted of cyclosporine , short-course methotrexate and steroids . CD3(+) , CD4(+) and CD19(+) cell reconstitution was slower in the high-dose group . Median time to reach 100 CD4(+) cells was 8 months vs 4 months ( P = 0.03 ) . Median time to normal CD19(+) cells was 16 months vs 8 months ( P = 0.01 ) . CD16(+)CD56(+) and CD8(+) cell reconstitution was similar . Nine patients in the high-dose group and two in the low-dose group experienced life-threatening opportunistic infections ( P = 0.009 ) . Although obtained from a limited number of patients , our data suggest that a higher pre-graft dose of antithymocyte globulin may negatively influence immune reconstitution .
    OUTPUT:

agent
avoiding immune destruction
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Antithymocyte globulin is widely used before haematopoietic transplantation with HLA-matched unrelated donors or mismatched relatives to prevent rejection and graft-versus-host disease ( GVHD ) . However , optimal dosage is still under debate . Thirty-one consecutive children , mainly with haematological malignancies , were transplanted in a single institution with such donors , selected by HLA-A -B compatibility by serology and DRB1* by DNA typing . Antithymocyte globulin ( Thymoglobuline ; Sangstat ) was infused at days -3 , -2 , -1 . Total dosage varied : 16 patients received a median of 7.5 mg/kg ( 2.5 to 10.5 : low-dose group ) , and 15 a median of 15.5 mg/kg ( 14.4 to 19.4 : high-dose group ) . Post-transplant GVHD prophylaxis consisted of cyclosporine , short-course methotrexate and steroids . CD3(+) , CD4(+) and CD19(+) cell reconstitution was slower in the high-dose group . Median time to reach 100 CD4(+) cells was 8 months vs 4 months ( P = 0.03 ) . Median time to normal CD19(+) cells was 16 months vs 8 months ( P = 0.01 ) . CD16(+)CD56(+) and CD8(+) cell reconstitution was similar . Nine patients in the high-dose group and two in the low-dose group experienced life-threatening opportunistic infections ( P = 0.009 ) . Although obtained from a limited number of patients , our data suggest that a higher pre-graft dose of antithymocyte globulin may negatively influence immune reconstitution .
    OUTPUT:
