human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Uncontrolled estrogen exposure can induce an imbalance in BCL2/BAX expression in endometrial cells , leading to precancerous lesions and type I endometrial adenocarcinoma . This study aimed to explore the mechanism underlying this phenomenon . We show that the activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a , thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells . These ER-regulated hsa-let-7 microRNAs can be detected in most hyperplastic endometria , suggesting their potential utility as indicators of estrogen over-exposure .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Uncontrolled estrogen exposure can induce an imbalance in BCL2/BAX expression in endometrial cells , leading to precancerous lesions and type I endometrial adenocarcinoma . This study aimed to explore the mechanism underlying this phenomenon . We show that the activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a , thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells . These ER-regulated hsa-let-7 microRNAs can be detected in most hyperplastic endometria , suggesting their potential utility as indicators of estrogen over-exposure .
    OUTPUT:
