human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Estrogen receptor Î± ( ERÎ± ) expression in breast cancer is predictive of response to endocrine therapy ; however , resistance is common in ERÎ±-positive tumors that overexpress the growth factor receptor ERBB2 . Even in the absence of estrogen , ERÎ± can be activated by growth factors , including the epidermal growth factor ( EGF ) . EGF induces a transcriptional program distinct from estrogen ; however , the mechanism of the stimulus-specific response is unknown . Here we show that the EGF-induced ERÎ± genomic targets , its cistromes , are distinct from those induced by estrogen in a process dependent on the transcription factor AP-1 . The EGF-induced ERÎ± cistrome specifically regulates genes found overexpressed in ERBB2-positive human breast cancers . This provides a potential molecular explanation for the endocrine therapy resistance seen in ERÎ±-positive breast cancers that overexpress ERBB2 . These results suggest a central role for ERÎ± in hormone-refractory breast tumors dependent on growth factor pathway activation and favors the development of therapeutic strategies completely antagonizing ERÎ± , as opposed to blocking its estrogen responsiveness alone .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Estrogen receptor Î± ( ERÎ± ) expression in breast cancer is predictive of response to endocrine therapy ; however , resistance is common in ERÎ±-positive tumors that overexpress the growth factor receptor ERBB2 . Even in the absence of estrogen , ERÎ± can be activated by growth factors , including the epidermal growth factor ( EGF ) . EGF induces a transcriptional program distinct from estrogen ; however , the mechanism of the stimulus-specific response is unknown . Here we show that the EGF-induced ERÎ± genomic targets , its cistromes , are distinct from those induced by estrogen in a process dependent on the transcription factor AP-1 . The EGF-induced ERÎ± cistrome specifically regulates genes found overexpressed in ERBB2-positive human breast cancers . This provides a potential molecular explanation for the endocrine therapy resistance seen in ERÎ±-positive breast cancers that overexpress ERBB2 . These results suggest a central role for ERÎ± in hormone-refractory breast tumors dependent on growth factor pathway activation and favors the development of therapeutic strategies completely antagonizing ERÎ± , as opposed to blocking its estrogen responsiveness alone .
    OUTPUT:
