human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE To investigate a potential mechanism of invasion and metastasis of oral cancers , and the possibility of the adhesion molecules being markers for evaluating the prognosis of oral cancers . METHODS Randomly selecting achieved paraffin blocks , including 60 cases of squamous cell carcinoma(SCC) , 30 cases of verrucous carcinoma(VC) of oral mucosa and 30 cases of basal cell carcinoma ( BCC ) of epidermis . All cases were followed up . Using immunohistochemistry method ( Envision ) to detect the expression of E-cadherin antibody and observe under light microscope . RESULTS The studies demonstrated that 38.2% of SCC had recurrence and/or metastases after operation . However , only 0.0% and 0.04% , in VC and BCC , respectively , had recurrence and/or metastases . There was significant difference on prognoses between SCC and VC or BCC . The immunostaining showed significant difference of E-cad expression between SCC and VC ( P&lt;0.01 ) , SCC and BCC ( P&lt;0.05 ) . The former was weaker than VC and BCC . However , no difference was showed in E-cad expression between VC and BCC ( P&gt;0.05 ) . CONCLUSION E-cad plays an important role in maintaining the phenotype of epithelial cell of SCC and normal oral mucosa . The degree of expression of E-cad was correlated with the ability of invasion and/or metastasis of SCC , VC and BCC . It indicates that E-cad may be as a helpful marker to evaluate the prognosis of oral cancers .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: OBJECTIVE To investigate a potential mechanism of invasion and metastasis of oral cancers , and the possibility of the adhesion molecules being markers for evaluating the prognosis of oral cancers . METHODS Randomly selecting achieved paraffin blocks , including 60 cases of squamous cell carcinoma(SCC) , 30 cases of verrucous carcinoma(VC) of oral mucosa and 30 cases of basal cell carcinoma ( BCC ) of epidermis . All cases were followed up . Using immunohistochemistry method ( Envision ) to detect the expression of E-cadherin antibody and observe under light microscope . RESULTS The studies demonstrated that 38.2% of SCC had recurrence and/or metastases after operation . However , only 0.0% and 0.04% , in VC and BCC , respectively , had recurrence and/or metastases . There was significant difference on prognoses between SCC and VC or BCC . The immunostaining showed significant difference of E-cad expression between SCC and VC ( P&lt;0.01 ) , SCC and BCC ( P&lt;0.05 ) . The former was weaker than VC and BCC . However , no difference was showed in E-cad expression between VC and BCC ( P&gt;0.05 ) . CONCLUSION E-cad plays an important role in maintaining the phenotype of epithelial cell of SCC and normal oral mucosa . The degree of expression of E-cad was correlated with the ability of invasion and/or metastasis of SCC , VC and BCC . It indicates that E-cad may be as a helpful marker to evaluate the prognosis of oral cancers .
    OUTPUT:
