human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Contradictory results have been reported regarding the association between vascularity ( used as an index of angiogenesis ) and thrombospondin-1 ( TSP-1 ) in human tumours . In previous studies , the reported association was based on the estimated average TSP-1 value per tumour , with a sufficient number of specimens collectively analysed per tumour type . Given the extent of intra-tumour heterogeneity , we determined the association between TSP-1 and vascularity within individual specimens , based on the average values of TSP-1 and vascularity in 10-20 pre-selected areas per tumour . Cells expressing TSP-1 mRNA were visualised by in situ hybridisation and quantified by point counting . Vascularity was quantified by point counting and vessel density of von Willebrand Factor-positive vessels . In 10 ductal breast carcinomas , a direct correlation between TSP-1 and vascularity was found in 4 tumours , no correlation in 3 and an inverse correlation in 3 . The effect of TSP-1 on endothelial cell migration in vitro was assessed in the Boyden chamber assay . TSP-1 stimulated cell migration at low concentrations ( 0.1-10 microg/ml ) and was inhibitory at high concentrations ( 25-100 microg/ml ) . These results suggest that TSP-1 may elicit a concentration-dependent , bi-phasic , effect on angiogenesis .
    OUTPUT:

agent
inducing angiogenesis;activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Contradictory results have been reported regarding the association between vascularity ( used as an index of angiogenesis ) and thrombospondin-1 ( TSP-1 ) in human tumours . In previous studies , the reported association was based on the estimated average TSP-1 value per tumour , with a sufficient number of specimens collectively analysed per tumour type . Given the extent of intra-tumour heterogeneity , we determined the association between TSP-1 and vascularity within individual specimens , based on the average values of TSP-1 and vascularity in 10-20 pre-selected areas per tumour . Cells expressing TSP-1 mRNA were visualised by in situ hybridisation and quantified by point counting . Vascularity was quantified by point counting and vessel density of von Willebrand Factor-positive vessels . In 10 ductal breast carcinomas , a direct correlation between TSP-1 and vascularity was found in 4 tumours , no correlation in 3 and an inverse correlation in 3 . The effect of TSP-1 on endothelial cell migration in vitro was assessed in the Boyden chamber assay . TSP-1 stimulated cell migration at low concentrations ( 0.1-10 microg/ml ) and was inhibitory at high concentrations ( 25-100 microg/ml ) . These results suggest that TSP-1 may elicit a concentration-dependent , bi-phasic , effect on angiogenesis .
    OUTPUT:
