human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: The orphan receptor TR3 is an important regulator of cell proliferation and apoptosis . However , whether TR3 is involved in regulating the stem-like properties of cancer cells remains unknown . The present study shows that TR3 expression is increased in gastric tumorsphere cells and is positively correlated with cancer stem cell ( CSC ) characteristics . Knocking down TR3 leads to the suppression of its stem-like properties in both gastric cancer cells and tumorsphere cells . This process involves the decreased expression of the stemness-related genes Oct-4 and Nanog and the invasion-related gene MMP-9 . We further identify Nanog as a new target for the transcription factor TR3 . Together , these data demonstrate for the first time that TR3 is essential for the maintenance of stem-like properties in human gastric cancer cells and implicate TR3 as a new therapeutic target for gastric cancer .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: The orphan receptor TR3 is an important regulator of cell proliferation and apoptosis . However , whether TR3 is involved in regulating the stem-like properties of cancer cells remains unknown . The present study shows that TR3 expression is increased in gastric tumorsphere cells and is positively correlated with cancer stem cell ( CSC ) characteristics . Knocking down TR3 leads to the suppression of its stem-like properties in both gastric cancer cells and tumorsphere cells . This process involves the decreased expression of the stemness-related genes Oct-4 and Nanog and the invasion-related gene MMP-9 . We further identify Nanog as a new target for the transcription factor TR3 . Together , these data demonstrate for the first time that TR3 is essential for the maintenance of stem-like properties in human gastric cancer cells and implicate TR3 as a new therapeutic target for gastric cancer .
    OUTPUT:
