human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Considerable debate centers on the optimal treatment for vulvar melanoma , as well as those clinicopathological factors influencing prognosis . We reviewed 80 patients with vulvar melanoma seen between 1949 and 1990 . Primary tumors were assessed according to Chung ( 47 patients ) and Breslow ( 65 patients ) microstaging systems . Fifty-nine patients ( 76% ) underwent radical vulvectomy , ten patients ( 13% ) had a partial vulvectomy , and nine patients ( 12% ) had a wide local excision . Fifty-six also underwent inguinal node dissection . Median follow-up was 193 months . Median survival was 63 months . Ten-year survival by Chung level was as follows : I 100% ; II , 81% ; III , 87% ; IV , 11% ; V , 33% . Ten-year survival by tumor thickness was as follows : 0.75 mm , 48% ; 0.75-1.5 mm , 68% ; 1.51-3.0 mm , 44% ; greater than 3.0 mm , 22% . Increased depth of invasion was associated with increased incidence of inguinal node metastasis . Cox regression analysis demonstrated prognostic significance for tumor thickness ( P less than 0.001 ) , inguinal node metastasis ( P less than 0.001 ) , and older age at diagnosis ( P less than 0.001 ) . Radical vulvectomy did not seem to improve survival over less radical procedures . Based on this experience , we recommend radical local excision for patients with malignant melanoma of the vulva . Patients who have more than a superficially invasive melanoma should also have inguinal lymph node dissection .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Considerable debate centers on the optimal treatment for vulvar melanoma , as well as those clinicopathological factors influencing prognosis . We reviewed 80 patients with vulvar melanoma seen between 1949 and 1990 . Primary tumors were assessed according to Chung ( 47 patients ) and Breslow ( 65 patients ) microstaging systems . Fifty-nine patients ( 76% ) underwent radical vulvectomy , ten patients ( 13% ) had a partial vulvectomy , and nine patients ( 12% ) had a wide local excision . Fifty-six also underwent inguinal node dissection . Median follow-up was 193 months . Median survival was 63 months . Ten-year survival by Chung level was as follows : I 100% ; II , 81% ; III , 87% ; IV , 11% ; V , 33% . Ten-year survival by tumor thickness was as follows : 0.75 mm , 48% ; 0.75-1.5 mm , 68% ; 1.51-3.0 mm , 44% ; greater than 3.0 mm , 22% . Increased depth of invasion was associated with increased incidence of inguinal node metastasis . Cox regression analysis demonstrated prognostic significance for tumor thickness ( P less than 0.001 ) , inguinal node metastasis ( P less than 0.001 ) , and older age at diagnosis ( P less than 0.001 ) . Radical vulvectomy did not seem to improve survival over less radical procedures . Based on this experience , we recommend radical local excision for patients with malignant melanoma of the vulva . Patients who have more than a superficially invasive melanoma should also have inguinal lymph node dissection .
    OUTPUT:
