human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Aurora A kinase has drawn considerable attention as a therapeutic target for cancer therapy . However , the underlying molecular and cellular mechanisms of the anticancer effects of Aurora A kinase inhibition are still not fully understood . Herein , we show that depletion of Aurora A kinase by RNA interference ( RNAi ) in hepatocellular carcinoma ( HCC ) cells upregulated FoxO1 in a p53-dependent manner , which induces cell cycle arrest . Introduction of an RNAi-resistant Aurora A kinase into Aurora A-knockdown cells resulted in downregulation of FoxO1 expression and rescued proliferation . In addition , silencing of FoxO1 in Aurora A-knockdown cells allowed the cells to exit cytostatic arrest , which , in turn , led to massive cell death . Our results suggest that FoxO1 is responsible for growth arrest at the G 2/M phase that is induced by Aurora A kinase inhibition .
    OUTPUT:

agent
evading growth suppressors;sustaining proliferative signaling;resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Aurora A kinase has drawn considerable attention as a therapeutic target for cancer therapy . However , the underlying molecular and cellular mechanisms of the anticancer effects of Aurora A kinase inhibition are still not fully understood . Herein , we show that depletion of Aurora A kinase by RNA interference ( RNAi ) in hepatocellular carcinoma ( HCC ) cells upregulated FoxO1 in a p53-dependent manner , which induces cell cycle arrest . Introduction of an RNAi-resistant Aurora A kinase into Aurora A-knockdown cells resulted in downregulation of FoxO1 expression and rescued proliferation . In addition , silencing of FoxO1 in Aurora A-knockdown cells allowed the cells to exit cytostatic arrest , which , in turn , led to massive cell death . Our results suggest that FoxO1 is responsible for growth arrest at the G 2/M phase that is induced by Aurora A kinase inhibition .
    OUTPUT:
