human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence , apoptosis , aging and aging-associated pathologies . Telomere shortening and genomic instability have also been associated with replicative senescence , aging and cancer . Here we show that mitochondrial dysfunction leads to telomere attrition , telomere loss , and chromosome fusion and breakage , accompanied by apoptosis . An antioxidant prevented telomere loss and genomic instability in cells with dysfunctional mitochondria , suggesting that reactive oxygen species are mediators linking mitochondrial dysfunction and genomic instability . Further , nuclear transfer protected genomes from telomere dysfunction and promoted cell survival by reconstitution with functional mitochondria . This work links mitochondrial dysfunction and genomic instability and may provide new therapeutic strategies to combat certain mitochondrial and aging-associated pathologies .
    OUTPUT:

agent
resisting cell death;genomic instability and mutation;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence , apoptosis , aging and aging-associated pathologies . Telomere shortening and genomic instability have also been associated with replicative senescence , aging and cancer . Here we show that mitochondrial dysfunction leads to telomere attrition , telomere loss , and chromosome fusion and breakage , accompanied by apoptosis . An antioxidant prevented telomere loss and genomic instability in cells with dysfunctional mitochondria , suggesting that reactive oxygen species are mediators linking mitochondrial dysfunction and genomic instability . Further , nuclear transfer protected genomes from telomere dysfunction and promoted cell survival by reconstitution with functional mitochondria . This work links mitochondrial dysfunction and genomic instability and may provide new therapeutic strategies to combat certain mitochondrial and aging-associated pathologies .
    OUTPUT:
