human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Recent surveys indicate that Pi intake has increased steadily as Pi-containing foods have increased . Our previous study demonstrated that high dietary Pi strongly stimulated lung tumorigeneis . In order to answer the issue whether low Pi may be chemopreventive , we examined the effects of low Pi on lung cancer . Eighteen 5-wk-old male K-ras(LA1) lung cancer model mice were randomly allocated to 2 groups . One group was fed a normal diet ( 0.5% Pi ) and other group was fed low Pi ( 0.1% Pi ) diet for 4 wk . Lung cancer development was evaluated by histopathological examination , Western blot , kinase assay , and immunohistochemistry . Low Pi increased the expression of sodium-dependent phosphate co-transporter 2b , and activated Akt signal with decreased PTEN expression in the lungs of K-ras(LA1) mice . Low Pi increased the Akt/mTOR-mediated protein translation through upregulating the phosphorylation of p70S6K and 4E-BP1 . In addition , low Pi stimulated cell cycling as evidenced by altered cell cycle regulators such as cyclin D1 and D3 . Finally , low Pi increased lung tumorigenesis in K-ras(LA1) mice compared to the normal diet group . Our results clearly demonstrated that low Pi also promoted lung tumorigenesis , thus suggesting that an appropriate intake of dietary Pi may be critical for lung cancer prevention as well as treatment .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Recent surveys indicate that Pi intake has increased steadily as Pi-containing foods have increased . Our previous study demonstrated that high dietary Pi strongly stimulated lung tumorigeneis . In order to answer the issue whether low Pi may be chemopreventive , we examined the effects of low Pi on lung cancer . Eighteen 5-wk-old male K-ras(LA1) lung cancer model mice were randomly allocated to 2 groups . One group was fed a normal diet ( 0.5% Pi ) and other group was fed low Pi ( 0.1% Pi ) diet for 4 wk . Lung cancer development was evaluated by histopathological examination , Western blot , kinase assay , and immunohistochemistry . Low Pi increased the expression of sodium-dependent phosphate co-transporter 2b , and activated Akt signal with decreased PTEN expression in the lungs of K-ras(LA1) mice . Low Pi increased the Akt/mTOR-mediated protein translation through upregulating the phosphorylation of p70S6K and 4E-BP1 . In addition , low Pi stimulated cell cycling as evidenced by altered cell cycle regulators such as cyclin D1 and D3 . Finally , low Pi increased lung tumorigenesis in K-ras(LA1) mice compared to the normal diet group . Our results clearly demonstrated that low Pi also promoted lung tumorigenesis , thus suggesting that an appropriate intake of dietary Pi may be critical for lung cancer prevention as well as treatment .
    OUTPUT:
