human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: To elucidate the function of MAS-related GPCR , member D ( MRGD ) in cancers , we investigated the in vitro and in vivo oncogenic function of MRGD using murine fibroblast cell line NIH3T3 in which MRGD is stably expressed . The expression pattern of MRGD in clinical samples was also analyzed . We found that overexpression of MRGD in NIH3T3 induced focus formation and multi-cellular spheroid formation , and promoted tumors in nude mice . In other words , overexpression of MRGD in NIH3T3 induced the loss of contact inhibition , anchorage-independent growth and in vivo tumorigenesis . Furthermore , it was found that the ligand of MRGD , beta-alanine , enhanced spheroid formation in MRGD-expressing NIH3T3 cells . From investigation of clinical cancer tissues , we found high expression of MRGD in several lung cancers by immunohistochemistry as well as real time PCR . Based on these results , MRGD could be involved in tumorigenesis and could also be a novel anticancer drug target .
    OUTPUT:

agent
evading growth suppressors
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: To elucidate the function of MAS-related GPCR , member D ( MRGD ) in cancers , we investigated the in vitro and in vivo oncogenic function of MRGD using murine fibroblast cell line NIH3T3 in which MRGD is stably expressed . The expression pattern of MRGD in clinical samples was also analyzed . We found that overexpression of MRGD in NIH3T3 induced focus formation and multi-cellular spheroid formation , and promoted tumors in nude mice . In other words , overexpression of MRGD in NIH3T3 induced the loss of contact inhibition , anchorage-independent growth and in vivo tumorigenesis . Furthermore , it was found that the ligand of MRGD , beta-alanine , enhanced spheroid formation in MRGD-expressing NIH3T3 cells . From investigation of clinical cancer tissues , we found high expression of MRGD in several lung cancers by immunohistochemistry as well as real time PCR . Based on these results , MRGD could be involved in tumorigenesis and could also be a novel anticancer drug target .
    OUTPUT:
