human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Piceatannol has potent anti-inflammatory , immunomodulatory , anticancer and antiproliferative effects . However , little is known about the mechanism by which piceatannol inhibits invasion and metastasis . The aim of the current study was to investigate the effects of piceatannol on the expression of matrix metalloproteinase-9 ( MMP-9 ) in DU145 human prostate cancer cells . The results revealed that MMP-9 activity was significantly increased in response to tumor necrosis factor-α ( TNF-α ) . However , treatment with piceatannol reversed TNF-α- and MMP-9-induced gelatin zymography and its gene expression . In addition , a Matrigel invasion assay determined that piceatannol reduces the TNF-α-induced invasion of DU145 cells . Nuclear factor-κ B ( NF-κB ) is a significant transcription factor that regulates numerous genes involved in tumor cell invasion and metastasis . Therefore , whether piceatannol acts on NF-κB to regulate MMP-9 gene expression was analyzed . The results revealed that piceatannol attenuates MMP-9 gene expression via the suppression of NF-κB activity . Using a specific NF-κB inhibitor , pyrrolidine dithiocarbamate , it was confirmed that TNF-α-induced MMP-9 gene expression is primarily regulated by NF-κB activation . Piceatannol inhibited NF-κB activity by suppressing nuclear translocation of the NF-κB p65 and p50 subunits . Furthermore , TNF-α-induced Akt phosphorylation was significantly downregulated in the presence of piceatannol . The Akt inhibitor LY294002 caused a significant decrease in TNF-α-induced NF-κB activity and MMP-9 gene expression . Overall , these data suggest that piceatannol inhibits TNF-α-induced invasion by suppression of MMP-9 activation via the Akt-mediated NF-κB pathway in DU145 prostate cancer cells .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Piceatannol has potent anti-inflammatory , immunomodulatory , anticancer and antiproliferative effects . However , little is known about the mechanism by which piceatannol inhibits invasion and metastasis . The aim of the current study was to investigate the effects of piceatannol on the expression of matrix metalloproteinase-9 ( MMP-9 ) in DU145 human prostate cancer cells . The results revealed that MMP-9 activity was significantly increased in response to tumor necrosis factor-α ( TNF-α ) . However , treatment with piceatannol reversed TNF-α- and MMP-9-induced gelatin zymography and its gene expression . In addition , a Matrigel invasion assay determined that piceatannol reduces the TNF-α-induced invasion of DU145 cells . Nuclear factor-κ B ( NF-κB ) is a significant transcription factor that regulates numerous genes involved in tumor cell invasion and metastasis . Therefore , whether piceatannol acts on NF-κB to regulate MMP-9 gene expression was analyzed . The results revealed that piceatannol attenuates MMP-9 gene expression via the suppression of NF-κB activity . Using a specific NF-κB inhibitor , pyrrolidine dithiocarbamate , it was confirmed that TNF-α-induced MMP-9 gene expression is primarily regulated by NF-κB activation . Piceatannol inhibited NF-κB activity by suppressing nuclear translocation of the NF-κB p65 and p50 subunits . Furthermore , TNF-α-induced Akt phosphorylation was significantly downregulated in the presence of piceatannol . The Akt inhibitor LY294002 caused a significant decrease in TNF-α-induced NF-κB activity and MMP-9 gene expression . Overall , these data suggest that piceatannol inhibits TNF-α-induced invasion by suppression of MMP-9 activation via the Akt-mediated NF-κB pathway in DU145 prostate cancer cells .
    OUTPUT:
