human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Prostate cancer is the second most common cancer in elderly men worldwide and its incidence rate is rising continuously . Agents capable of inducing apoptosis in prostate cancer cells seem a promising approach to treat this malignancy . In this study we describe the synthesis of a number of novel N- and N,N'-substituted S-2,3,4,5,6-pentabromobenzylisothiouronium bromides and their activity against the human prostate adenocarcinoma PC3 cell line . All the compounds produced changes in mitochondrial transmembrane potential and cell cycle progression , showed a cytostatic effect and induced apoptosis in the tested cancer line in a concentration- and time-dependent manner . The most effective compounds ZKK-3 , ZKK-9 and ZKK-13 produced , at 20 microM concentration , apoptosis in 42 , 46 , and 66% of the cells , respectively , after 48 h incubation . Two selected S-2,3,4,5,6-pentabromobenzylisothiouronium bromides ( ZKK-3 , ZKK-9 ) showed also a synergic proapoptotic effect with the new casein kinase II inhibitor 2-(4-methylpiperazin-1-yl)-4,5,6,7-tetrabromo-1H-benzimidazole ( TBIPIP ) in the PC3 cell line .
    OUTPUT:

agent
resisting cell death;sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Prostate cancer is the second most common cancer in elderly men worldwide and its incidence rate is rising continuously . Agents capable of inducing apoptosis in prostate cancer cells seem a promising approach to treat this malignancy . In this study we describe the synthesis of a number of novel N- and N,N'-substituted S-2,3,4,5,6-pentabromobenzylisothiouronium bromides and their activity against the human prostate adenocarcinoma PC3 cell line . All the compounds produced changes in mitochondrial transmembrane potential and cell cycle progression , showed a cytostatic effect and induced apoptosis in the tested cancer line in a concentration- and time-dependent manner . The most effective compounds ZKK-3 , ZKK-9 and ZKK-13 produced , at 20 microM concentration , apoptosis in 42 , 46 , and 66% of the cells , respectively , after 48 h incubation . Two selected S-2,3,4,5,6-pentabromobenzylisothiouronium bromides ( ZKK-3 , ZKK-9 ) showed also a synergic proapoptotic effect with the new casein kinase II inhibitor 2-(4-methylpiperazin-1-yl)-4,5,6,7-tetrabromo-1H-benzimidazole ( TBIPIP ) in the PC3 cell line .
    OUTPUT:
