human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Purpose . The purpose of this paper is to evaluate a new PET tracer ( 64)Cu-NODAGA-c(RGDyK ) for imaging of tumor angiogenesis using gene expression of angiogenesis markers as reference and to estimate radiation dosimetry for humans . Procedures . Nude mice with human neuroendocrine tumor xenografts ( H727 ) were administered ( 64)Cu-NODAGA-c(RGDyK ) i.v. for study of biodistribution as well as for dynamic PET . Gene expression of angiogenesis markers integrin Î±(V) , integrin Î²(3) , and VEGF-A were analyzed using QPCR and correlated to the tracer uptake in the tumors ( %ID/g ) . From biodistribution data human radiation-absorbed doses were estimated using OLINDA/EXM . Results . Tumor uptake was 1.2%ID/g with strong correlations between gene expression and tracer uptake , for integrin Î±(V)âR = 0.76 , integrin Î²(3)âR = 0.75 and VEGF-A R = 0.81 ( all P &lt ; 0.05 ) . The whole body effective dose for humans was estimated to be 0.038 and 0.029âmSv/MBq for females and males , respectively , with highest absorbed dose in bladder wall . Conclusion . ( 64)Cu-NODAGA-c(RGDyK ) is a promising new angiogenesis PET tracer with potential for human use .
    OUTPUT:

agent
inducing angiogenesis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Purpose . The purpose of this paper is to evaluate a new PET tracer ( 64)Cu-NODAGA-c(RGDyK ) for imaging of tumor angiogenesis using gene expression of angiogenesis markers as reference and to estimate radiation dosimetry for humans . Procedures . Nude mice with human neuroendocrine tumor xenografts ( H727 ) were administered ( 64)Cu-NODAGA-c(RGDyK ) i.v. for study of biodistribution as well as for dynamic PET . Gene expression of angiogenesis markers integrin Î±(V) , integrin Î²(3) , and VEGF-A were analyzed using QPCR and correlated to the tracer uptake in the tumors ( %ID/g ) . From biodistribution data human radiation-absorbed doses were estimated using OLINDA/EXM . Results . Tumor uptake was 1.2%ID/g with strong correlations between gene expression and tracer uptake , for integrin Î±(V)âR = 0.76 , integrin Î²(3)âR = 0.75 and VEGF-A R = 0.81 ( all P &lt ; 0.05 ) . The whole body effective dose for humans was estimated to be 0.038 and 0.029âmSv/MBq for females and males , respectively , with highest absorbed dose in bladder wall . Conclusion . ( 64)Cu-NODAGA-c(RGDyK ) is a promising new angiogenesis PET tracer with potential for human use .
    OUTPUT:
