human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Base analogs are powerful antimetabolites and dangerous mutagens generated endogenously by oxidative stress , inflammation , and aberrant nucleotide biosynthesis . Human inosine triphosphate pyrophosphatase ( ITPA ) hydrolyzes triphosphates of noncanonical purine bases ( i.e. , ITP , dITP , XTP , dXTP , or their mimic : 6-hydroxyaminopurine ( HAP ) deoxynucleoside triphosphate ) and thus regulates nucleotide pools and protects cells from DNA damage . We demonstrate that the model purine base analog HAP induces DNA breaks in human cells and leads to elevation of levels of ITPA . A human polymorphic allele of the ITPA , 94C-&gt;A encodes for the enzyme with a P32T amino-acid change and leads to accumulation of nonhydrolyzed ITP . The polymorphism has been associated with adverse reaction to purine base-analog drugs . The level of both spontaneous and HAP-induced DNA breaks is elevated in the cell line with the ITPA P32T variant . The results suggested that human ITPA plays a pivotal role in the protection of DNA from noncanonical purine base analogs .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Base analogs are powerful antimetabolites and dangerous mutagens generated endogenously by oxidative stress , inflammation , and aberrant nucleotide biosynthesis . Human inosine triphosphate pyrophosphatase ( ITPA ) hydrolyzes triphosphates of noncanonical purine bases ( i.e. , ITP , dITP , XTP , dXTP , or their mimic : 6-hydroxyaminopurine ( HAP ) deoxynucleoside triphosphate ) and thus regulates nucleotide pools and protects cells from DNA damage . We demonstrate that the model purine base analog HAP induces DNA breaks in human cells and leads to elevation of levels of ITPA . A human polymorphic allele of the ITPA , 94C-&gt;A encodes for the enzyme with a P32T amino-acid change and leads to accumulation of nonhydrolyzed ITP . The polymorphism has been associated with adverse reaction to purine base-analog drugs . The level of both spontaneous and HAP-induced DNA breaks is elevated in the cell line with the ITPA P32T variant . The results suggested that human ITPA plays a pivotal role in the protection of DNA from noncanonical purine base analogs .
    OUTPUT:
