human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Breast cancer consists in a chronic inflammatory disease with multiple biological and clinical behaviors . Based on high throughput technologies data , this disease is currently classified according to the molecular expression of estrogen ( ER ) , progesterone ( PR ) and human epidermal growth factor ( HER-2 ) receptors . In this study , we defined the inflammatory profile of the main molecular subtypes of breast cancer patients : luminal ( ER and PR positive , HER-2 negative ) , HER-2 enriched ( HER-2 positive ) and triple negative ( ER , PR and HER-2 negative ) . Cytokines panel was assessed by measurement of TNF-Î± , TGF-Î² , IL-1 , IL-10 and IL-12 plasmatic levels . Oxidative profile was assessed by determination of lipid peroxidation , total antioxidant capacity of plasma , malondialdehyde levels , carbonyl content and nitric oxide ( NO ) . Clinical data were correlated with inflammatory findings . Our findings demonstrated that patients bearing the luminal subtype displayed high TNF-Î± , TGF-Î² and enhanced oxidative stress levels associated with reduced IL-12 . HER-2-enriched group exhibited higher levels of TNF-Î± , IL-12 and TGF-Î² associated with enhanced oxidative stress . Triple-negative subtype exhibited the most aggressive profile of disease behavior , with reduction in both TNF-Î± and TGF-Î² , with high levels of lipid peroxidation and NO . The clinical importance of our findings lies in the fact that the inflammatory status varies in distinct ways due to molecular subtype of breast cancer , opening potential therapeutic targets to future therapies .
    OUTPUT:

agent
tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Breast cancer consists in a chronic inflammatory disease with multiple biological and clinical behaviors . Based on high throughput technologies data , this disease is currently classified according to the molecular expression of estrogen ( ER ) , progesterone ( PR ) and human epidermal growth factor ( HER-2 ) receptors . In this study , we defined the inflammatory profile of the main molecular subtypes of breast cancer patients : luminal ( ER and PR positive , HER-2 negative ) , HER-2 enriched ( HER-2 positive ) and triple negative ( ER , PR and HER-2 negative ) . Cytokines panel was assessed by measurement of TNF-Î± , TGF-Î² , IL-1 , IL-10 and IL-12 plasmatic levels . Oxidative profile was assessed by determination of lipid peroxidation , total antioxidant capacity of plasma , malondialdehyde levels , carbonyl content and nitric oxide ( NO ) . Clinical data were correlated with inflammatory findings . Our findings demonstrated that patients bearing the luminal subtype displayed high TNF-Î± , TGF-Î² and enhanced oxidative stress levels associated with reduced IL-12 . HER-2-enriched group exhibited higher levels of TNF-Î± , IL-12 and TGF-Î² associated with enhanced oxidative stress . Triple-negative subtype exhibited the most aggressive profile of disease behavior , with reduction in both TNF-Î± and TGF-Î² , with high levels of lipid peroxidation and NO . The clinical importance of our findings lies in the fact that the inflammatory status varies in distinct ways due to molecular subtype of breast cancer , opening potential therapeutic targets to future therapies .
    OUTPUT:
