human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Curcumin ( diferuloylmethane ) is a polyphenol derived from the plant turmeric ( Curcuma longa ) , which is commonly used as a spice . Although anti-carcinogenic , anti-oxidant , anti-inflammation , and anti-angiogenic properties have been reported , the effect of curcumin on breast cancer metastasis is unknown . Matrix metalloproteinase-9 ( MMP-9 ) is a major component in cancer cell invasion . In this study , we investigated the inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate ( TPA)-induced MMP-9 expression and cell invasion and the molecular mechanisms involved in MCF-7 cells . Our results showed that curcumin inhibits TPA-induced MMP-9 expression and cell invasion through suppressing NF-ÎºB and AP-1 activation . Also , curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCÎ± from the cytosol to the membrane , but did not affect the translocation of PKCÎ´ . These results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCÎ± , MAPK and NF-ÎºB/AP-1 pathway in MCF-7 cells . Curcumin may have potential value in restricting breast cancer metastasis .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Curcumin ( diferuloylmethane ) is a polyphenol derived from the plant turmeric ( Curcuma longa ) , which is commonly used as a spice . Although anti-carcinogenic , anti-oxidant , anti-inflammation , and anti-angiogenic properties have been reported , the effect of curcumin on breast cancer metastasis is unknown . Matrix metalloproteinase-9 ( MMP-9 ) is a major component in cancer cell invasion . In this study , we investigated the inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate ( TPA)-induced MMP-9 expression and cell invasion and the molecular mechanisms involved in MCF-7 cells . Our results showed that curcumin inhibits TPA-induced MMP-9 expression and cell invasion through suppressing NF-ÎºB and AP-1 activation . Also , curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCÎ± from the cytosol to the membrane , but did not affect the translocation of PKCÎ´ . These results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCÎ± , MAPK and NF-ÎºB/AP-1 pathway in MCF-7 cells . Curcumin may have potential value in restricting breast cancer metastasis .
    OUTPUT:
