human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: In spite of numerous advances , the 5-year survival rate for head and neck squamous cell cancer has remained largely stagnant and few new anti-tumor drugs have been developed . PCH4 , a derivative of n-butylidenephthalide , has been investigated for its anti-tumor effects on oral squamous cell carcinoma ( OSCC ) . The aim of this study was to investigate the anti-tumor mechanism of a potential target gene , Nur77 , in OSCC cells , which can be induced by PCH4 treatment . Data show that PCH4 promoted Nur77 translocation from the nucleus to the cytoplasm and induced cell apoptosis in OSCC cells . When Nur77 translocation was blocked , the degree of tumor apoptosis caused by PCH4 was significantly inhibited ( pâ&lt;â0.05 ) . Within the MAPK pathway , PCH4 only induced JNK phosphorylation . Furthermore , treatment with a JNK inhibitor significantly reduced PCH4-induced apoptosis ( pâ&lt;â0.05 ) and decreased PCH4-induced Nur77 expression ( pâ&lt;â0.05 ) . In a xenograft animal model , administration of PCH4 also showed anti-tumor effects . We have demonstrated that OSCC cells are sensitive to PCH4 and that Nur77 protein translocation from the nucleus to the cytoplasm might be associated with the induction of apoptosis by PCH4 . These results indicate that PCH4 may serve as a potential anti-tumor drug for OSCC therapy .
    OUTPUT:

agent
resisting cell death
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: In spite of numerous advances , the 5-year survival rate for head and neck squamous cell cancer has remained largely stagnant and few new anti-tumor drugs have been developed . PCH4 , a derivative of n-butylidenephthalide , has been investigated for its anti-tumor effects on oral squamous cell carcinoma ( OSCC ) . The aim of this study was to investigate the anti-tumor mechanism of a potential target gene , Nur77 , in OSCC cells , which can be induced by PCH4 treatment . Data show that PCH4 promoted Nur77 translocation from the nucleus to the cytoplasm and induced cell apoptosis in OSCC cells . When Nur77 translocation was blocked , the degree of tumor apoptosis caused by PCH4 was significantly inhibited ( pâ&lt;â0.05 ) . Within the MAPK pathway , PCH4 only induced JNK phosphorylation . Furthermore , treatment with a JNK inhibitor significantly reduced PCH4-induced apoptosis ( pâ&lt;â0.05 ) and decreased PCH4-induced Nur77 expression ( pâ&lt;â0.05 ) . In a xenograft animal model , administration of PCH4 also showed anti-tumor effects . We have demonstrated that OSCC cells are sensitive to PCH4 and that Nur77 protein translocation from the nucleus to the cytoplasm might be associated with the induction of apoptosis by PCH4 . These results indicate that PCH4 may serve as a potential anti-tumor drug for OSCC therapy .
    OUTPUT:
