human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Filamin-A cross-links actin filaments into dynamic orthogonal networks , and interacts with an array of proteins of diverse cellular functions . Because several filamin-A interaction partners are implicated in signaling of cell mobility regulation , we tested the hypothesis that filamin-A plays a role in cancer metastasis . Using four pairs of filamin-A proficient and deficient isogenic cell lines , we found that filamin-A deficiency in cancer cells significantly reduces their migration and invasion . Using a xenograft tumor model with subcutaneous and intracardiac injections of tumor cells , we found that the filamin-A deficiency causes significant reduction of lung , splenic and systemic metastasis in nude mice . We evaluated the expression of filamin-A in breast cancer tissues by immunohistochemical staining , and found that low levels of filamin-A expression in cancer cells of the tumor tissues are associated with a better distant metastasis-free survival than those with normal levels of filamin-A . These data not only validate filamin-A as a prognostic marker for cancer metastasis , but also suggest that inhibition of filamin-A in cancer cells may reduce metastasis and that filamin-A can be used as a therapeutic target for filamin-A positive cancer .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Filamin-A cross-links actin filaments into dynamic orthogonal networks , and interacts with an array of proteins of diverse cellular functions . Because several filamin-A interaction partners are implicated in signaling of cell mobility regulation , we tested the hypothesis that filamin-A plays a role in cancer metastasis . Using four pairs of filamin-A proficient and deficient isogenic cell lines , we found that filamin-A deficiency in cancer cells significantly reduces their migration and invasion . Using a xenograft tumor model with subcutaneous and intracardiac injections of tumor cells , we found that the filamin-A deficiency causes significant reduction of lung , splenic and systemic metastasis in nude mice . We evaluated the expression of filamin-A in breast cancer tissues by immunohistochemical staining , and found that low levels of filamin-A expression in cancer cells of the tumor tissues are associated with a better distant metastasis-free survival than those with normal levels of filamin-A . These data not only validate filamin-A as a prognostic marker for cancer metastasis , but also suggest that inhibition of filamin-A in cancer cells may reduce metastasis and that filamin-A can be used as a therapeutic target for filamin-A positive cancer .
    OUTPUT:
