human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Diarylquinoline compounds are newly synthesized derivatives of the new anti-tuberculosis drug , TMC207 . In this study , nine diarylquinoline compounds were screened for cytotoxic activity against human tumor cells , and their mechanisms of action were investigated . Among the nine compounds , STM-57 [ N-((6-bromo-2-methoxyquinolin-3-yl)(phenyl)methl)-N-(3,4-dichlorophenyl)-3-(4 -methylpiperazin-1-yl)propanamide ] showed potent cytotoxic activity . STM-57 induced caspase-independent cell death in the human nasopharyngeal carcinoma cell line , CNE-2 . Further investigation showed that STM-57 induced autophagy , as determined with the increased expression of green fluorescent protein-light chain3 ( GFP-LC3 ) and increased LC3-II levels . STM-57 inhibited the phosphorylation of Akt and the mammalian target of rapamycin ( mTOR ) in CNE-2 cells . The intracellular calcium concentration and reactive oxygen species levels were increased in CNE-2 cells following treatment with STM-57 , whereas the mitochondrial transmembrane potential ( ÎÎ¨m ) and ATP concentrations were decreased .
    OUTPUT:

agent
resisting cell death;tumor promoting inflammation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Diarylquinoline compounds are newly synthesized derivatives of the new anti-tuberculosis drug , TMC207 . In this study , nine diarylquinoline compounds were screened for cytotoxic activity against human tumor cells , and their mechanisms of action were investigated . Among the nine compounds , STM-57 [ N-((6-bromo-2-methoxyquinolin-3-yl)(phenyl)methl)-N-(3,4-dichlorophenyl)-3-(4 -methylpiperazin-1-yl)propanamide ] showed potent cytotoxic activity . STM-57 induced caspase-independent cell death in the human nasopharyngeal carcinoma cell line , CNE-2 . Further investigation showed that STM-57 induced autophagy , as determined with the increased expression of green fluorescent protein-light chain3 ( GFP-LC3 ) and increased LC3-II levels . STM-57 inhibited the phosphorylation of Akt and the mammalian target of rapamycin ( mTOR ) in CNE-2 cells . The intracellular calcium concentration and reactive oxygen species levels were increased in CNE-2 cells following treatment with STM-57 , whereas the mitochondrial transmembrane potential ( ÎÎ¨m ) and ATP concentrations were decreased .
    OUTPUT:
