human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Bisphenol A is a monomer used in the production of polycarbonate plastics , epoxy resins , and flame retardants . It is an endocrine disruptor with a variety of other effects , including genotoxicity . Oxidative metabolism of bisphenol A yields electophilic bisphenol A-3,4-quinone ( BPAQ ) , which may cause genotoxicity . To determine the genotoxic potential of bisphenol A , the mechanism of the reaction between the BPAQ and deoxyadenosine ( dA ) was studied in detail . The most probable reaction pathway was determined using quantum chemical methods . Our results demonstrate that the rate limiting step is Michael addition between BPAQ and dA , the main product being the unstable N7-modified adduct that rapidly undergoes depurination . In addition , our calculations provide strong evidence for protonation of the adducts prior to depurination , which indicates pH dependence of the reaction . The calculated activation barrier for Michael addition is 28.7 kcal/mol , indicating that the reaction with dA is very slow . Comparison with the activation energy of 23.1 kcal/mol for the corresponding deoxyguanosine reaction indicates that most of the DNA damage by BPAQ will occur at the guanine site . The detoxification reactions with glutathione compete with reactions between BPAQ and DNA . The calculated free energy of activation for the reaction with glutathione is significantly lower than that for the corresponding reaction with dA . This indicates that BPAQ will preferably react with glutathione and will only react with DNA when the level of glutathione in the cell is low .
    OUTPUT:

agent
genomic instability and mutation
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Bisphenol A is a monomer used in the production of polycarbonate plastics , epoxy resins , and flame retardants . It is an endocrine disruptor with a variety of other effects , including genotoxicity . Oxidative metabolism of bisphenol A yields electophilic bisphenol A-3,4-quinone ( BPAQ ) , which may cause genotoxicity . To determine the genotoxic potential of bisphenol A , the mechanism of the reaction between the BPAQ and deoxyadenosine ( dA ) was studied in detail . The most probable reaction pathway was determined using quantum chemical methods . Our results demonstrate that the rate limiting step is Michael addition between BPAQ and dA , the main product being the unstable N7-modified adduct that rapidly undergoes depurination . In addition , our calculations provide strong evidence for protonation of the adducts prior to depurination , which indicates pH dependence of the reaction . The calculated activation barrier for Michael addition is 28.7 kcal/mol , indicating that the reaction with dA is very slow . Comparison with the activation energy of 23.1 kcal/mol for the corresponding deoxyguanosine reaction indicates that most of the DNA damage by BPAQ will occur at the guanine site . The detoxification reactions with glutathione compete with reactions between BPAQ and DNA . The calculated free energy of activation for the reaction with glutathione is significantly lower than that for the corresponding reaction with dA . This indicates that BPAQ will preferably react with glutathione and will only react with DNA when the level of glutathione in the cell is low .
    OUTPUT:
