human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: OBJECTIVE The HER2 receptor is involved in pathways essential for cell proliferation , and is an important predictive and prognostic factor in breast cancer . HER2 probably plays a critical role in many types of cancer , including urothelial carcinoma of the bladder ( UCB ) . Stage T1 UCB exhibits heterogeneous clinical behaviour , and the frequency of HER2 expression in such disease has not been thoroughly examined . The aim of this study was to use an immunohistochemical technique to evaluate the frequency of HER2 expression in a defined population-based cohort of patients registered as having primary stage T1 UCB . MATERIAL AND METHODS The initial study population comprised 285 patients registered as having primary stage T1 UCB . The original histological specimens were re-evaluated with regard to T stage and World Health Organization grade . Hospital records provided information on tumour size , multiplicity , possible presence of histologically proven recurrence and progression . The patients were followed for at least 5 years or until death . In tumours still considered stage T1 after re-evaluation , HER2 was investigated by immunohistochemistry of paraffin-embedded material and scored according to the guidelines used in breast cancer . RESULTS After histopathological re-evaluation , 201 patients were still T1 UCB and could be investigated regarding HER2 expression . HER2 overexpression was observed in 25 of those patients ( 12.4% ) . HER2 status was not significantly associated with recurrence or progression . CONCLUSIONS HER2 was overexpressed in 12.4% of the present cohort of patients with primary stage T1 UCB . There was no significant association between tumour HER2 status and prognosis .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: OBJECTIVE The HER2 receptor is involved in pathways essential for cell proliferation , and is an important predictive and prognostic factor in breast cancer . HER2 probably plays a critical role in many types of cancer , including urothelial carcinoma of the bladder ( UCB ) . Stage T1 UCB exhibits heterogeneous clinical behaviour , and the frequency of HER2 expression in such disease has not been thoroughly examined . The aim of this study was to use an immunohistochemical technique to evaluate the frequency of HER2 expression in a defined population-based cohort of patients registered as having primary stage T1 UCB . MATERIAL AND METHODS The initial study population comprised 285 patients registered as having primary stage T1 UCB . The original histological specimens were re-evaluated with regard to T stage and World Health Organization grade . Hospital records provided information on tumour size , multiplicity , possible presence of histologically proven recurrence and progression . The patients were followed for at least 5 years or until death . In tumours still considered stage T1 after re-evaluation , HER2 was investigated by immunohistochemistry of paraffin-embedded material and scored according to the guidelines used in breast cancer . RESULTS After histopathological re-evaluation , 201 patients were still T1 UCB and could be investigated regarding HER2 expression . HER2 overexpression was observed in 25 of those patients ( 12.4% ) . HER2 status was not significantly associated with recurrence or progression . CONCLUSIONS HER2 was overexpressed in 12.4% of the present cohort of patients with primary stage T1 UCB . There was no significant association between tumour HER2 status and prognosis .
    OUTPUT:
