human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Each year , more than 700,000 people undergo cancer surgery in the United States . However , more than 40% of those patients develop recurrences and have a poor outcome . Traditionally , the medical community has assumed that recurrent tumors arise from selected tumor clones that are refractory to therapy . However , we found that tumor cells have few phenotypical differences after surgery . Thus , we propose an alternative explanation for the resistance of recurrent tumors . Surgery promotes inhibitory factors that allow lingering immunosuppressive cells to repopulate small pockets of residual disease quickly . Recurrent tumors and draining lymph nodes are infiltrated with M2 ( CD11b(+)F4/80(hi)CD206(hi) and CD11b(+)F4/80(hi)CD124(hi) ) macrophages and CD4(+)Foxp3(+) regulatory T cells . This complex network of immunosuppression in the surrounding tumor microenvironment explains the resistance of tumor recurrences to conventional cancer vaccines despite small tumor size , an intact antitumor immune response , and unaltered cancer cells . Therapeutic strategies coupling antitumor agents with inhibition of immunosuppressive cells potentially could impact the outcomes of more than 250,000 people each year .
    OUTPUT:

agent
avoiding immune destruction
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Each year , more than 700,000 people undergo cancer surgery in the United States . However , more than 40% of those patients develop recurrences and have a poor outcome . Traditionally , the medical community has assumed that recurrent tumors arise from selected tumor clones that are refractory to therapy . However , we found that tumor cells have few phenotypical differences after surgery . Thus , we propose an alternative explanation for the resistance of recurrent tumors . Surgery promotes inhibitory factors that allow lingering immunosuppressive cells to repopulate small pockets of residual disease quickly . Recurrent tumors and draining lymph nodes are infiltrated with M2 ( CD11b(+)F4/80(hi)CD206(hi) and CD11b(+)F4/80(hi)CD124(hi) ) macrophages and CD4(+)Foxp3(+) regulatory T cells . This complex network of immunosuppression in the surrounding tumor microenvironment explains the resistance of tumor recurrences to conventional cancer vaccines despite small tumor size , an intact antitumor immune response , and unaltered cancer cells . Therapeutic strategies coupling antitumor agents with inhibition of immunosuppressive cells potentially could impact the outcomes of more than 250,000 people each year .
    OUTPUT:
