human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Lewis y ( LeY ) antigen is a difucosylated oligosaccharide carried by glycoconjugates on the cell surface . Overexpression of LeY is frequently observed in epithelial-derived cancers and has been correlated to the pathological staging and prognosis . However , the effects of LeY on ovarian cancer are not yet clear . Previously , we transfected the ovarian cancer cell line RMG-I with the Î±1,2-fucosyltransferase gene to obtain stable transfectants , RMG-I-H , that highly express LeY . In the present study , we examined the proliferation , tumorigenesis , adhesion and invasion of the cell lines with treatment of LeY monoclonal antibody ( mAb ) . Additionally , we examined the expression of TGF-Î²1 , VEGF and b-FGF in xenograft tumors . The results showed that the proliferation and adhesion in vitro were significantly inhibited by treatment of RMG-I-H cells with LeY mAb . When subcutaneously inoculated in nude mice , RMG-I-H cells produced large tumors , while mock-transfected cells RMG-I-C and the parental cells RMG-I produced small tumors . Moreover , the tumor formation by RMG-I-H cells was inhibited by preincubating the cells with LeY mAb . Notably , the expression of TGF-Î²1 , VEGF and b-FGF all increased in RMG-I-H cells . In conclusion , LeY plays an important role in promoting cell proliferation , tumorigenecity and adhesion , and these effects may be related to increased levels of growth factors . The LeY antibody shows potential application in the treatment of LeY-positive tumors .
    OUTPUT:

agent
sustaining proliferative signaling
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Lewis y ( LeY ) antigen is a difucosylated oligosaccharide carried by glycoconjugates on the cell surface . Overexpression of LeY is frequently observed in epithelial-derived cancers and has been correlated to the pathological staging and prognosis . However , the effects of LeY on ovarian cancer are not yet clear . Previously , we transfected the ovarian cancer cell line RMG-I with the Î±1,2-fucosyltransferase gene to obtain stable transfectants , RMG-I-H , that highly express LeY . In the present study , we examined the proliferation , tumorigenesis , adhesion and invasion of the cell lines with treatment of LeY monoclonal antibody ( mAb ) . Additionally , we examined the expression of TGF-Î²1 , VEGF and b-FGF in xenograft tumors . The results showed that the proliferation and adhesion in vitro were significantly inhibited by treatment of RMG-I-H cells with LeY mAb . When subcutaneously inoculated in nude mice , RMG-I-H cells produced large tumors , while mock-transfected cells RMG-I-C and the parental cells RMG-I produced small tumors . Moreover , the tumor formation by RMG-I-H cells was inhibited by preincubating the cells with LeY mAb . Notably , the expression of TGF-Î²1 , VEGF and b-FGF all increased in RMG-I-H cells . In conclusion , LeY plays an important role in promoting cell proliferation , tumorigenecity and adhesion , and these effects may be related to increased levels of growth factors . The LeY antibody shows potential application in the treatment of LeY-positive tumors .
    OUTPUT:
