human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: BACKGROUND Intracystic papillary carcinoma ( IPC ) of the breast is a rare form of noninvasive breast cancer . An appreciation of associated pathology with IPC may be critical in surgical decision-making . METHODS The medical records of all patients with IPC treated between 1985 and 2001 were retrospectively reviewed . Three patient groups were identified according to the pathologic features of the primary tumor : IPC alone , IPC with associated ductal carcinoma in situ ( DCIS ) , and IPC with associated invasion with or without DCIS . Types of treatment and outcomes were compared between groups . RESULTS Forty patients were treated for IPC during the study period . Fourteen had pure IPC , 13 had IPC with DCIS , and 13 had IPC with invasion . The incidence of recurrence and the likelihood of dying of IPC did not differ between the three groups regardless of the type of surgery ( mastectomy or segmental mastectomy ) performed and whether radiation therapy was administered . The disease-specific survival rate was 100% . CONCLUSIONS When IPC is identified , it is frequently associated with DCIS and or invasion . Standard therapy should be based on associated pathology . The role of radiation therapy in pure IPC remains to be determined .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: BACKGROUND Intracystic papillary carcinoma ( IPC ) of the breast is a rare form of noninvasive breast cancer . An appreciation of associated pathology with IPC may be critical in surgical decision-making . METHODS The medical records of all patients with IPC treated between 1985 and 2001 were retrospectively reviewed . Three patient groups were identified according to the pathologic features of the primary tumor : IPC alone , IPC with associated ductal carcinoma in situ ( DCIS ) , and IPC with associated invasion with or without DCIS . Types of treatment and outcomes were compared between groups . RESULTS Forty patients were treated for IPC during the study period . Fourteen had pure IPC , 13 had IPC with DCIS , and 13 had IPC with invasion . The incidence of recurrence and the likelihood of dying of IPC did not differ between the three groups regardless of the type of surgery ( mastectomy or segmental mastectomy ) performed and whether radiation therapy was administered . The disease-specific survival rate was 100% . CONCLUSIONS When IPC is identified , it is frequently associated with DCIS and or invasion . Standard therapy should be based on associated pathology . The role of radiation therapy in pure IPC remains to be determined .
    OUTPUT:
