human
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
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    INPUT: Momordica charantia has been found to exhibit anticancer activity , in addition to its well-known therapeutic functions . We have demonstrated that the leaf extract of Momordica charantia ( MCME ) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways . In this study , a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability , leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells . MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities . We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt , Î²-catenin , and MMPs .
    OUTPUT:

agent
activating invasion and metastasis
The task is to decide the Hallmarks of Cancer (HOC) taxonomy of the article based on its abstract. The input is an abstract text. There are 10 topics you will need to decide whether the article is related to. Topics: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genomic instability and mutation, tumor promoting inflammation, cellular energetics, avoiding immune destruction. The output should be topics from the above 10 topics, that are related to the input article. Please note one article can be related to multiple topics. Output format: provide a semicolon-separated list of relevant topics.
    ###
    INPUT: Momordica charantia has been found to exhibit anticancer activity , in addition to its well-known therapeutic functions . We have demonstrated that the leaf extract of Momordica charantia ( MCME ) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways . In this study , a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability , leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells . MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities . We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt , Î²-catenin , and MMPs .
    OUTPUT:
