***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: One new study was identified for this 2018 update, bringing the total number of included studies to two and the total number of participants to 451. Both trials discharged patients randomised to the outpatient group within 36 hours of initial triage and both followed participants for 90 days. One study compared the same treatment regimens in both outpatient and inpatient groups, and the other study used different treatment regimes. There was no clear difference in treatment effect for the outcomes of short-term mortality (30 days) (RR 0.33, 95% CI 0.01 to 7.98, P = 0.49; low-quality evidence), long-term mortality (90 days) (RR 0.98, 95% CI 0.06 to 15.58, P = 0.99, low-quality evidence), major bleeding at 14 days (RR 4.91, 95% CI 0.24 to 101.57, P = 0.30; low-quality evidence) and at 90 days (RR 6.88, 95% CI 0.36 to 132.14, P = 0.20; low-quality evidence), minor bleeding (RR 1.08, 95% CI 0.07 to 16.79; P = 0.96, low-quality evidence), recurrent PE within 90 days (RR 2.95, 95% CI 0.12 to 71.85, P = 0.51, low-quality evidence), and participant satisfaction (RR 0.97, 95% CI 0.90 to 1.04, P = 0.39; moderate-quality evidence). We downgraded the quality of the evidence because the CIs were wide and included treatment effects in both directions, the sample sizes and numbers of events were small, and because the effect of missing data and the absence of publication bias could not be verified. PE-related mortality, and adverse effects such as haemodynamic instability and compliance, were not assessed by the included studies. Currently, only low-quality evidence is available from two published randomised controlled trials on outpatient versus inpatient treatment in low-risk patients with acute PE. The studies did not provide evidence of any clear difference between the interventions in overall mortality, bleeding and recurrence of PE.
Output:

We searched scientific databases for clinical trials of low-risk adults (aged 18 years and over) allocated to home (outpatient) management or hospital (inpatient) management of acute PE. The evidence is current to March 2018. We included two studies, which included a total of 453 people. We are uncertain whether, compared with inpatient treatment, outpatient treatment has an important effect on number of deaths, bleeding, recurrence of PE, and patient satisfaction because the results were imprecise and the studies did not report side effects such as haemodynamic instability (where drugs or procedures are needed to maintain a stable blood pressure), and compliance (how well people follow medical advice). The evidence from the included studies was of low quality because of imprecision in the results. This was due to there being only small numbers of people in the studies (and small numbers of events), and because we could not confirm the absence of publication bias (reports of studies where no effect was shown might not be published). Therefore, further well-conducted randomised controlled trials (where people are allocated at random to one of two or more treatment groups, one of which is a control treatment) are required before informed practice decisions can be made.