***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: There were two small randomised controlled trials including a total of 23 infants eligible for inclusion in the review. Only one trial involving 16 infants included in the analysis reported on either of the primary outcomes of the review. This found no difference in failure of modality between NIV-NAVA and NIPPV (RR 0.33, 95% CI 0.02 to 7.14; RD −0.13, 95% CI -0.41 to 0.16; 1 study, 16 infants; heterogeneity not applicable). Both trials reported on secondary outcomes of the review, specific for cross-over trials (total 22 infants; 1 excluded due to failure of initial modality). One study involving seven infants reported a significant reduction in maximum FiO₂ with NIV-NAVA compared to NIPPV (MD −4.29, 95% CI −5.47 to −3.11; heterogeneity not applicable). There was no difference in maximum electric activity of the diaphragm (Edi) signal between modalities (MD −1.75, 95% CI −3.75 to 0.26; I² = 0%) and a significant increase in respiratory rate with NIV-NAVA compared to NIPPV (MD 7.22, 95% CI 0.21 to 14.22; I² = 72%) on a meta-analysis of two studies involving a total of 22 infants. The included studies did not report on other outcomes of interest. Due to limited data and very low certainty evidence, we were unable to determine if diaphragm-triggered non-invasive respiratory support is effective or safe in preventing respiratory failure in preterm infants. Large, adequately powered randomised controlled trials are needed to determine if diaphragm-triggered non-invasive respiratory support in preterm infants is effective or safe.
Output:

We found 15 studies that assessed the effect of diaphragm-triggered non-invasive respiratory support in infants through searches of medical databases up to 10 May 2019. Of these 15, two studies (involving a total of 23 preterm infants) were eligible for inclusion in the review. Ten studies were either awaiting publication or are ongoing. There is limited data from randomised controlled trials to determine the effect of diaphragm-triggered non-invasive respiratory support on important outcomes. We were able to include only two small randomised controlled trials in the review. Both studies involved infants switching from one type of support to the other and were focused on short-term changes in breathing patterns. We were not able to make any meaningful conclusions in this review due to limited data and very low quality evidence. Large, high-quality studies are needed to determine whether diaphragm-triggered non-invasive respiratory support can prevent respiratory failure.