***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: Four trials involving 649 participants were included in this review. Two of these trials (459 participants) were designed as randomised, double-blind, placebo-controlled trials with an adequate methodological description; the other two trials (190 participants) described an inadequate methodological design. All four trials with 649 participants were included in the meta-analysis. Significant differences were noted in rates of restenosis, recurrence angina pectoris, and serious cardiovascular adverse events between Xiongshao capsule plus conventional western medicine and the same conventional western medicine alone; RR values (95% CIs) were 0.41 (0.22 to 0.75), 0.47 (0.31 to 0.72), and 0.47 (0.25 to 0.90), respectively. Xiongshao capsule plus conventional western medicine showed more significant reductions in restenosis (RR 0.52, 95% CI 0.33 to 0.80), recurrence angina pectoris (RR 0.26, 95% CI 0.18 to 0.38), and serious cardiovascular adverse events (RR 0.45, 95% CI 0.28 to 0.70) than the same conventional western medicine plus placebo. Safety outcomes and adverse events of the Xiongshao capsule were reported in two trials, which reported no adverse events. The summary estimates indicate a protective effect of Xiongshao on restenosis and suggest that Xiongshao capsule may be used to prevent restenosis after a PCI procedure in CHD patients. However, this evidence is derived from small randomised trials, all conducted in China, and two of the included trials showed important methodological limitations that undermine the validity of the findings. Additional high-quality research trials with sufficient sample size are required.
Output:

We identified four trials that tested treatments based on Xiongshao capsule. Two trials compared Xiongshao capsule plus conventional western medicine with the same conventional western medicine plus placebo; the other two trials compared Xiongshao capsule plus conventional western medicine with the same conventional western medicine alone for preventing restenosis after a PCI procedure in CHD patients. These trials reported that use of Xiongshao capsule caused a significant reduction in the incidence rates of restenosis, recurrence angina pectoris, and serious cardiovascular adverse events with no substantive adverse effects following a PCI procedure. Therefore Xiongshao capsule may represent a choice for the prevention of in-stent restenosis following a PCI procedure. However, although summary estimates indicate a protective effect of Xiongshao on restenosis, evidence is derived in part from small randomised trials, all conducted in China, with some methodological limitations that undermine the validity of the findings. Additional high-quality research trials with sufficient sample size are required.