***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: Twenty-nine studies met the criteria for detailed scrutiny. However, none of these met the pre-determined criteria for comparative groups and none included comparisons between randomly allocated groups of pregnant women. While there is no doubt that penicillin is effective in the treatment of syphilis in pregnancy and the prevention of congenital syphilis, uncertainty remains about what are the optimal treatment regimens. Further studies are needed to evaluate treatment failure cases with currently recommended regimens and this should include an assessment of the role of HIV infection in cases of prenatal syphilis treatment failure. The effectiveness of various antibiotic regimens for the treatment of primary and secondary syphilis in pregnant women need to be assessed using randomised controlled trials which compare them with existing recommendations. This should include treatment with oral antibiotics which could be particularly relevant in resource-poor countries where the availability of safe needles and syringes cannot be guaranteed.
Output:

Syphilis is a potentially fatal, sexually transmitted disease that passes from a pregnant woman to her unborn baby. If the woman is untreated, the fetus might be aborted or her baby may be born with the disease, suffer permanent disability and be disfigured. The effectiveness of penicillin in curing infection with syphilis in pregnant women and preventing the baby being born with congenital syphilis was established soon after its introduction in the 1940s and before the widespread use of randomised controlled trials. Although rare in developed countries, the incidence of syphilis is high and increasing in many developing countries, particularly where HIV/AIDS is common. The review of trials found no trials comparing the effectiveness of different doses of penicillin or comparing penicillin with other antibiotics. More research is needed to find the best dosage and duration of treatment.