***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: Only one eligible study, involving 21 participants, was included. The study compared platelet-rich therapy and allogenic bone graft with allogenic bone graft alone in patients undergoing corrective osteotomy for medial compartment osteoarthrosis of the knee. The risk of bias associated with this study was substantial. There was no significant difference in patient-reported or clinician-assessed functional outcome scores between groups at one year. There was a statistically significant benefit from platelet-rich therapy in the proportion of bones that were united at one year (8/9 versus 3/9; RR 2.67; 95% CI 1.03 to 6.91). This benefit, however, was not maintained when assuming poor outcomes for participants who were lost to follow-up (8/11 versus 3/10; RR 2.42; 95% CI 0.88 to 6.68). One adverse event was reported in a participant receiving platelet-rich therapy. One other eligible study involving hip fracture patients is currently underway. While a potential benefit of platelet-rich therapies to augment long bone healing in adults cannot be ruled out, the currently available evidence from a single trial is insufficient to support the routine use of this intervention in clinical practice. Future trials should focus on reporting patient-reported functional outcomes from all trial participants for a minimum follow-up of one year.
Output:

Only one study, involving 21 participants, was included in this review. The study compared PRT and bone graft versus bone graft alone (control) in patients with osteoarthritis of the knee who had surgery where a wedge of bone was cut (osteotomy) from their tibia (shin bone) in order to change the pattern of weight bearing on the knee. As in a fracture, the time for the bone to heal is an important factor in determining recovery after an osteotomy. The study found no difference between the PRT and control groups in patient-reported or clinician-assessed functional outcomes at one year. However, based on radiographic (x-ray) measures of bone healing, the study found a higher proportion of bones had healed by one year in those participants who had completed the study. One adverse event was reported in a participant receiving platelet-rich therapy From the limited evidence that is currently available, the review found that PRT had no effect on functional outcomes. PRT may be beneficial in accelerating and improving the incidence of union in osteotomies. The only complication reported was not necessarily related to the PRT treatment. No data were available regarding PRT in the treatment of acute fractures, non-united fractures or large bony defects. One other study involving hip fracture patients is currently underway, and will provide further evidence concerning the use of PRT in the future.