***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: We included 10 studies (12 trial reports) from which 5041 women contributed data for the primary outcome. The overall risk of bias was low. When comparing prophylactic intravenous (IV) antibiotic administration in women undergoing cesarean delivery, there was a reduction in composite maternal infectious morbidity (risk ratio (RR) 0.57, 95% confidence interval (CI) 0.45 to 0.72, high quality evidence), which was specifically due to the reduction in endometritis (RR 0.54, 95% CI 0.36 to 0.79, high quality evidence) and wound infection (RR 0.59, 95% CI 0.44 to 0.81, high quality evidence) in those that received antibiotics preoperatively as compared to those who received antibiotics after neonatal cord clamping. There were no clear differences in neonatal sepsis (RR 0.76, 95% CI 0.51 to 1.13, moderate quality evidence). There were no clear differences for other maternal outcomes such as urinary tract infection (UTI), cystitis and pyelonephritis (moderate quality evidence), respiratory infection (low quality evidence), or any neonatal outcomes. Maternal side effects were not reported in the included studies. The quality of the evidence using GRADE was high for composite morbidity, endomyometritis, wound infection and neonatal intensive care unit admission, moderate for UTI/cystitis/pyelonephritis and neonatal sepsis, and low for maternal respiratory infection. Based on high quality evidence from studies whose overall risk of bias is low, intravenous prophylactic antibiotics for cesarean administered preoperatively significantly decreases the incidence of composite maternal postpartum infectious morbidity as compared with administration after cord clamp. There were no clear differences in adverse neonatal outcomes reported. Women undergoing cesarean delivery should receive antibiotic prophylaxis preoperatively to reduce maternal infectious morbidities. Further research may be needed to elucidate short- and long-term adverse effects for neonates.
Output:

This review of randomized controlled studies looked at the different timing options for administration of prophylactic antibiotics to prevent infectious complications in women undergoing cesarean delivery. We compared preoperative administration to administration after the cord had been clamped. The review includes 10 studies (with data from 5041 women). The studies were at a low risk of bias. Antibiotics given to women before cesarean delivery nearly halved the risks of combined infections (43%), endometritis (46%), and wound infection (41%) compared to giving the antibiotics after clamping of the baby’s umbilical. Other maternal infections such as urinary or lung infections were no different between the two groups of women, nor were adverse effects in newborns. High quality evidence shows that preoperative intravenous antibiotic administration decreases postpartum infections and is, therefore, beneficial for the mother. Maternal side effects were not consistently reported. Numbers were limited with respect to information on newborns and any adverse outcomes. Further research may be needed to determine adverse effects on the babies.