***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: Three RCTs were identified. A qualitative approach with no meta analysis was performed because of variety in interventions between included studies. Interventions compared were antibiotics to no antibiotics, single to double compound antibiotic therapy and short to long IV administration. None of the studies found significant difference between the tested interventions. Risk of bias varied from low to high. The newest RCT overall had the best quality and statistical power. The newest evidence from one RCT says there is no significant difference between antibiotics versus no antibiotics in the treatment of uncomplicated diverticulitis. Previous RCTs have only suggested a non-inferiority between different antibiotic regimes and treatment lengths. This new evidence needs confirmation from more RCTs before it can be implicated safely in clinical guidelines. Ongoing RCTs will be published in the years to come and more are needed. The role of antibiotics in the treatment of complicated diverticulitis has not been investigated yet.
Output:

We found 3 randomized controlled trials (RCTs) on the use of antibiotics for uncomplicated diverticulitis tested on hospitalised patients. The newest trial investigating the actual need for antibiotics when compared to no antibiotics, a second investigated two different antibiotic cures and a third investigated the length of IV antibiotic treatment. None of the studies found a statistical difference in the tested antibiotic regimes. The newest trial had the overall best quality and had the biggest groups of patients making it the overall best trial. It found no difference in the occurrence of surgery needing complications like abscesses and perforations of the big bowel. Antibiotics can cause serious adverse events for patients like allergic reactions and can even cause other life threatening infections of the bowel. Ultimately, there is a growing antibiotic resistance meaning that the drugs loose their ability to function as bactericidals. This causes limitations in the clinical use of antibiotics when they are needed for treating patients with infections. Therefore there exists strong arguments for limiting the use of antibiotics. The trial that showed no effect of antibiotics is very new and needs confirmation from other similar trials. Ongoing trials will in the next few years be published on the subject.