***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: Only one trial met the inclusion criteria for this review which was a small, open-label, unblinded, randomised trial of the safety and feasibility of switching from phenytoin to levetiracetam monotherapy or continuing phenytoin for glioma-related seizure control following craniotomy (Lim 2009). Levetiracetam (a non enzyme-inducing antiepileptic drug) appears to have been at least as well tolerated and as effective as phenytoin (an enzyme-inducing antiepileptic drug) for the treatment of seizures in people with brain tumours. Eighty-seven per cent of participants treated with levetiracetam were free of seizures at six months compared with 75% of participants treated with phenytoin.   There is one ongoing study of levetiracetam versus pregabalin for the treatment of seizures in adults undergoing chemotherapy, radiotherapy,or both for primary brain tumours. No data from this study were available at the time of preparing this review. There is a lack of robust, randomised, controlled evidence to support the choice of antiepileptic drug for the treatment of seizures in adults with brain tumours. While some authors support the use of non enzyme-inducing antiepileptic drugs, reliable, comparative evidence to provide clinical justification for this is limited. There is a need for further large, randomised, controlled trials in this area.
Output:

There is a lack of good quality evidence to support the choice of any particular antiepileptic drug for the treatment of seizures in adults with brain tumours. Our searches identified one small randomised trial directly comparing two different antiepileptic drugs (phenytoin and levetiracetam) for the treatment of seizures in adults with brain tumours. No significant difference was identified between the effectiveness of these two drugs. This small study was intended as a feasibility study for a larger trial that was not carried out. We also identified one ongoing study of levetiracetam versus pregabalin for the treatment of seizures in adults undergoing chemotherapy, radiotherapy,or both for primary brain tumours although no data from this study were available at the time of preparing this review. We identified a number of other small studies but we excluded them from the review as they were not randomised controlled trials. There is a clear need for larger randomised controlled trials to study the effectiveness of different antiepileptic drugs in the treatment of seizures in adults with brain tumours.