***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: Of the 1233 patients enrolled in nine identified trials, 622 were treated with staples and 611 with manual suture. The following main results were obtained.  a) Mortality, result based on 901 patients: RD -0.6%, 95% CI -2.8% to +1.6%.  b) Overall dehiscence, result based on 1233 patients: RD 0.2%, 95% CI -5.0% to +5.3%.  c) Clinical anastomotic dehiscence, result based on 1233 patients: RD -1.4%, 95% CI -5.2 to +2.3%.  d) Radiological anastomotic dehiscence, result based on 825 patients: RD 1.2%, 95% CI -4.8% to +7.3%.  e) Stricture, result based on 1042 patients: RD 4.6%, 95% CI 1.2% to 8.1%; NNT 17, 95% CI 12 to 31.  f) Anastomotic haemorrhage, result based on 662 patients: RD 2.7%, 95% CI -0.1% to +5.5%.  g) Reoperation, result based on 544 patients: RD 3.9%, 95% CI 0.3% to 7.4%.  h) Wound infection, result based on 567 patients: RD 1.0%, 95% CI -2.2% to +4.3%.  i) Anastomosis duration, result based on one study (159 patients): WMD -7.6 minutes, 95% CI -12.9 to -2.2 minutes.  j) Hospital stay, result based on one study (159 patients): WMD 2.0 days, 95% CI -3.27 to +7.2 days. The evidence found was insufficient to demonstrate any superiority of stapled over handsewn techniques in colorectal anastomosis surgery, regardless of the level of anastomosis. There were no randomised clinical trials comparing these two types of anastomosis in elective conditions in the last decade. The relevance of this research question has possibly lost its strength where elective surgery is concerned. However, in risk situations, such as emergency surgery, trauma and inflammatory bowel disease, new clinical trials are needed.
Output:

The review with nine randomised controlled trials (1233 patients, 622 with stapling and 611 with the handsewing technique) compared the safety and effectiveness of stapled versus handsewn colorectal anastomosis surgery. Meta-analysis was performed using the risk difference and weighted mean difference, with corresponding 95% confidence intervals. Outcome measures were mortality, anastomotic dehiscence, narrowing (stricture), haemorrhage, need for reoperation, wound infection, anastomosis duration (time taken to perform the anastomosis) and hospital stay. No significant statistical differences were found except that stricture was more frequent with stapling (P < 0.05) and the time taken to perform the anastomosis was longer with handsewn techniques.