***TASK***
the task is to simplify the input abstract of a biomedical literature

***INPUT***
the input is the abstract of a biomedical literature

***OUTPUT***
the output is the simplified abstract for the input abstract of a biomedical literature

***DOCUMENTATION***

***EXAMPLES***

Input: Two studies compared corticosteroids to placebo and six studies compared corticosteroids to 5-ASA. Corticosteroids were found to be significantly more effective than placebo at inducing remission in CD (RR 1.99; 95% CI 1.51 to 2.64; P < 0.00001). Corticosteroids were found to be more effective than 5-ASA at inducing remission in studies with long follow-up duration (i.e. > 15 weeks; RR 1.65; 95% CI 1.33 to 2.03; P < 0.00001). Corticosteroids induced adverse events in a higher proportion of patients than placebo (RR 4.89; 95% CI 1.98 to 12.07; P = 0.0006), or low-dose 5-ASA (RR 2.38; 95% CI 1.34 to 4.25; P = 0.003). No difference existed in the proportion of patients experiencing adverse events when steroids were compared to high-dose 5-ASA. Steroids did not induce more study withdrawals due to adverse events than either placebo or 5-ASA. Corticosteroids are effective for induction of remission in patients with CD, particularly when used for more than 15 weeks. Although corticosteroids cause more adverse events than either placebo or low-dose 5-ASA, these adverse events did not lead to increased study withdrawal in the included studies. Further information is required to determine the optimal duration of treatment and tapering protocol to maximize the efficacy of treatment with corticosteroids. Additionally, further study is required to determine whether corticosteroids are more effective in patients with certain phenotypes or when administered intravenously.
Output:

Controlled clinical studies that evaluated the effect of systemic corticosteroids to induce remission in Crohn's disease were reviewed. For inclusion in this analysis, studies could compare any form of corticosteroid that is systemically absorbed (e.g. prednisone, prednisolone, 6-methylprednisolone or hydrocortisone) to either placebo (fake medicine) or 5-aminosalicylates (e.g. mesalazine, mesalamine or sulfasalazine). Corticosteroids were found to be more effective than either placebo or 5-aminosalicylates at inducing remission in Crohn's disease. Although corticosteroids caused side effects more often in patients compared with placebo and 5-aminosalicylates, these side effects were not serious enough to cause withdrawal from the studies reviewed. In summary, corticosteroids are effective at inducing remission in patients with Crohn's disease. While they cause frequent side effects, these side effects were relatively minor in the reviewed studies, some of which followed patients for up to 24 weeks.