In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Capecitabine has a well - established safety profile and can be given safely to patients with advanced age , hepatic and renal dysfunctions .
### Output Text:
<span class="chemical">Capecitabine</span> has a well - established safety profile and can be given safely to patients with advanced age , hepatic and renal dysfunctions . 