In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: This case report highlights the fact that the angiotensin II receptor antagonist losartan can cause serious unexpected complications in patients with renovascular disease and should be used with extreme caution in this setting .
### Output Text:
This case report highlights the fact that the <span class="chemical">angiotensin II</span> receptor antagonist <span class="chemical">losartan</span> can cause serious unexpected complications in patients with renovascular disease and should be used with extreme caution in this setting . 