In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The development of thrombotic microangiopathy ( TMA ) associated with the use of cyclosporine has been well documented .
### Output Text:
The development of thrombotic microangiopathy ( TMA ) associated with the use of <span class="chemical">cyclosporine</span> has been well documented . 