In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CONCLUSION : Cocaine use predisposed aneurysmal rupture at a significantly earlier age and in much smaller aneurysms .
### Output Text:
CONCLUSION : <span class="chemical">Cocaine</span> use predisposed aneurysmal rupture at a significantly earlier age and in much smaller aneurysms . 