In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: TCR prevented the isoproterenol - induced decrease in antioxidant enzymes in the heart and increased the rate of ADP - stimulated oxygen uptake and respiratory coupling ratio .
### Output Text:
<span class="chemical">TCR</span> prevented the <span class="chemical">isoproterenol</span> - induced decrease in antioxidant enzymes in the heart and increased the rate of <span class="chemical">ADP</span> - stimulated <span class="chemical">oxygen</span> uptake and respiratory coupling ratio . 