In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In salt - depleted rats , amphotericin B decreased creatinine clearance linearly with time , with an 85 % reduction by week 3 .
### Output Text:
In salt - depleted rats , <span class="chemical">amphotericin B</span> decreased <span class="chemical">creatinine</span> clearance linearly with time , with an 85 % reduction by week 3 . 