In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Whole body hyperthermia ( 120 min at 41 . 5 degrees C ) enhanced both Adriamycin - mediated antitumor activity and toxic side effects .
### Output Text:
Whole body hyperthermia ( 120 min at 41 . 5 degrees C ) enhanced both <span class="chemical">Adriamycin</span> - mediated antitumor activity and toxic side effects . 