In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: It is suggested that the effects of Captopril on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin ( secondary to an increase in bradykinin ) .
### Output Text:
It is suggested that the effects of <span class="chemical">Captopril</span> on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of <span class="chemical">Angiotension II</span> and an increase in <span class="chemical">prostacyclin</span> ( secondary to an increase in <span class="chemical">bradykinin</span> ) . 