In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Patients without proteinuria had increased renal function ( median 42 . 5 vs . 64 . 1 , p = 0 . 25 ) , whereas patients who developed high - grade proteinuria showed decreased renal function at the end of follow - up ( median 39 . 6 vs . 29 . 2 , p = 0 . 125 ) .
### Output Text:
Patients without proteinuria had increased renal function ( median 42 . 5 vs . 64 . 1 , p = 0 . 25 ) , whereas patients who developed high - grade proteinuria showed decreased renal function at the end of follow - up ( median 39 . 6 vs . 29 . 2 , p = 0 . 125 ) . 