In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: An analysis is presented of 220 cases of possible neurotoxic reactions to halogenated hydroxyquinolines reported from outside Japan .
### Output Text:
An analysis is presented of 220 cases of possible neurotoxic reactions to <span class="chemical">halogenated hydroxyquinolines</span> reported from outside Japan . 