In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: During the first day of hospitalization ( while intubated ) , intravenous metoprolol was given , resulting in severe angioedema .
### Output Text:
During the first day of hospitalization ( while intubated ) , intravenous <span class="chemical">metoprolol</span> was given , resulting in severe angioedema . 