In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Treatments have included discontinuation or reduction of cyclosporine dose with or without concurrent plasma exchange , plasma infusion , anticoagulation , and intravenous immunoglobulin G infusion .
### Output Text:
Treatments have included discontinuation or reduction of <span class="chemical">cyclosporine</span> dose with or without concurrent plasma exchange , plasma infusion , anticoagulation , and intravenous immunoglobulin G infusion . 