In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: There was a statistically significant ( P < or = 0 . 01 ) decrease in movement in coniine and nicotine sulfate treated chicks as determined by ultrasound .
### Output Text:
There was a statistically significant ( P < or = 0 . 01 ) decrease in movement in <span class="chemical">coniine</span> and <span class="chemical">nicotine</span> sulfate treated chicks as determined by ultrasound . 