In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Lastly , we measured PRL - R and suppressor of cytokine signaling ( SOCS - 1 and - 3 and CIS , which reflect the level of prolactin signaling ) mRNAs in response to sulpiride and estradiol .
### Output Text:
Lastly , we measured PRL - R and suppressor of cytokine signaling ( SOCS - 1 and - 3 and CIS , which reflect the level of prolactin signaling ) mRNAs in response to <span class="chemical">sulpiride</span> and <span class="chemical">estradiol</span> . 