In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In all clones with combined immune escape and LAM resistance mutations , the nucleotide analogues adefovir and tenofovir remained effective in suppressing viral replication in vitro .
### Output Text:
In all clones with combined immune escape and <span class="chemical">LAM</span> resistance mutations , the <span class="chemical">nucleotide</span> analogues <span class="chemical">adefovir</span> and <span class="chemical">tenofovir</span> remained effective in suppressing viral replication in vitro . 