In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: However , we suggest that a low solution concentration should be preferred for unilateral spinal anaesthesia with a hyperbaric anaesthetic solution ( if pencil - point needle and slow injection rate are employed ) , in order to minimize the risk of a localized high peak anaesthetic concentration , which might lead to a transient neurological deficit .
### Output Text:
However , we suggest that a low solution concentration should be preferred for unilateral spinal anaesthesia with a hyperbaric anaesthetic solution ( if pencil - point needle and slow injection rate are employed ) , in order to minimize the risk of a localized high peak anaesthetic concentration , which might lead to a transient neurological deficit . 