In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: We have utilized the human monocyte cell line , THP - 1 as a model to address this question .
### Output Text:
We have utilized the human monocyte cell line , THP - 1 as a model to address this question . 