In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Recently , however , we have had an increase of patients who are presenting after OLTX with end - stage renal disease ( ESRD ) .
### Output Text:
Recently , however , we have had an increase of patients who are presenting after OLTX with end - stage renal disease ( ESRD ) . 