In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Use of flestolol in the critical care setting is currently undergoing investigation .
### Output Text:
Use of <span class="chemical">flestolol</span> in the critical care setting is currently undergoing investigation . 