In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The management options in the ED , as exemplified by four individual case reports , in particular the use of a minimally invasive method of intracorporal epinephrine instillation , are discussed .
### Output Text:
The management options in the ED , as exemplified by four individual case reports , in particular the use of a minimally invasive method of intracorporal <span class="chemical">epinephrine</span> instillation , are discussed . 