In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Permeability of the blood - brain barrier was quantitated by clearance of fluorescent - labeled dextran before and during phenylephrine - induced acute hypertension in rats treated with vehicle and Hoe - 140 ( 0 . 1 microM ) .
### Output Text:
Permeability of the blood - brain barrier was quantitated by clearance of fluorescent - labeled <span class="chemical">dextran</span> before and during <span class="chemical">phenylephrine</span> - induced acute hypertension in rats treated with vehicle and <span class="chemical">Hoe - 140</span> ( 0 . 1 microM ) . 