In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: These effects may be relevant in the treatment of cocaine dependence .
### Output Text:
These effects may be relevant in the treatment of <span class="chemical">cocaine</span> dependence . 