In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Furthermore , adriamycin induced the formation of autophagic vacuoles , and 3MA strongly downregulated the expression of beclin 1 in adriamycin - induced failing heart and inhibited the formation of autophagic vacuoles .
### Output Text:
Furthermore , <span class="chemical">adriamycin</span> induced the formation of autophagic vacuoles , and <span class="chemical">3MA</span> strongly downregulated the expression of beclin 1 in <span class="chemical">adriamycin</span> - induced failing heart and inhibited the formation of autophagic vacuoles . 