In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: RESULTS : Three months of raloxifene treatment was associated with a significant decrease in the plasma TAFI antigen concentrations ( 16 % change , P < 0 . 01 ) , and a significant increase in tPA antigen concentrations ( 25 % change , P < 0 . 05 ) .
### Output Text:
RESULTS : Three months of <span class="chemical">raloxifene</span> treatment was associated with a significant decrease in the plasma TAFI antigen concentrations ( 16 % change , P < 0 . 01 ) , and a significant increase in tPA antigen concentrations ( 25 % change , P < 0 . 05 ) . 