In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CONCLUSIONS : Spironolactone - induced hyperkalemia and renal insufficiency are more common in our clinical experience than reported previously .
### Output Text:
CONCLUSIONS : <span class="chemical">Spironolactone</span> - induced hyperkalemia and renal insufficiency are more common in our clinical experience than reported previously . 