In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The proportion of possibly avoidable cases due to drug interactions was estimated .
### Output Text:
The proportion of possibly avoidable cases due to drug interactions was estimated . 