In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: At the end of study period , serum phenobarbitone and carbamazepine , whole brain malondialdehyde and reduced glutathione levels were estimated .
### Output Text:
At the end of study period , serum <span class="chemical">phenobarbitone</span> and <span class="chemical">carbamazepine</span> , whole brain <span class="chemical">malondialdehyde</span> and reduced <span class="chemical">glutathione</span> levels were estimated . 