In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: As a result , switching to tacrolimus has been reported to be a viable therapeutic option in the setting of cyclosporine - induced TMA .
### Output Text:
As a result , switching to <span class="chemical">tacrolimus</span> has been reported to be a viable therapeutic option in the setting of <span class="chemical">cyclosporine</span> - induced TMA . 