In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Thus , proteinuria may develop in cardiac transplant patients after switch to Srl , which may have an adverse effect on renal function in these patients .
### Output Text:
Thus , proteinuria may develop in cardiac transplant patients after switch to <span class="chemical">Srl</span> , which may have an adverse effect on renal function in these patients . 