In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: METHODS : The Multiple Outcomes of Raloxifene Evaluation , a multicenter , randomized , double - blind trial , enrolled 7 , 705 postmenopausal women with osteoporosis .
### Output Text:
METHODS : The Multiple Outcomes of <span class="chemical">Raloxifene</span> Evaluation , a multicenter , randomized , double - blind trial , enrolled 7 , 705 postmenopausal women with osteoporosis . 