In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: For the cytoprotection study , animals were orally gavaged 100 mg / Kg GSPE for 7 - 10 days followed by i . p . injections of organ specific three drugs ( AAP : 500 mg / Kg for 24 h ; AMI : 50 mg / Kg / day for four days ; DOX : 20 mg / Kg for 48 h ) .
### Output Text:
For the cytoprotection study , animals were orally gavaged 100 mg / Kg <span class="chemical">GSPE</span> for 7 - 10 days followed by i . p . injections of organ specific three drugs ( <span class="chemical">AAP</span> : 500 mg / Kg for 24 h ; <span class="chemical">AMI</span> : 50 mg / Kg / day for four days ; <span class="chemical">DOX</span> : 20 mg / Kg for 48 h ) . 