In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Organelles of these cells , in particular the mitochondria ( increased number and size , distinct degeneration of their matrix and cristae ) and Golgi apparatus were altered .
### Output Text:
Organelles of these cells , in particular the mitochondria ( increased number and size , distinct degeneration of their matrix and cristae ) and Golgi apparatus were altered . 