In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Renal function was investigated by measuring plasma and urinary electrolytes , glucosuria , proteinuria , aminoaciduria , urinary pH , osmolarity , creatinine clearance , phosphate tubular reabsorption , beta 2 microglobulinuria , and lysozymuria .
### Output Text:
Renal function was investigated by measuring plasma and urinary electrolytes , glucosuria , proteinuria , aminoaciduria , urinary pH , osmolarity , <span class="chemical">creatinine</span> clearance , <span class="chemical">phosphate</span> tubular reabsorption , beta 2 microglobulinuria , and lysozymuria . 