In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Adriamycinol , doxorubicin , adriamycinone , and tetrahydropyranyladriamycinol were the metabolites detected in plasma and the amount of doxorubicin was less than or equal to 10 % of the total metabolites .
### Output Text:
<span class="chemical">Adriamycinol</span> , <span class="chemical">doxorubicin</span> , <span class="chemical">adriamycinone</span> , and <span class="chemical">tetrahydropyranyladriamycinol</span> were the metabolites detected in plasma and the amount of <span class="chemical">doxorubicin</span> was less than or equal to 10 % of the total metabolites . 