In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The aim of this study was to investigate whether autophagy was involved in the progression of heart failure induced by adriamycin , so that we can develop a novel treatment strategy for heart failure .
### Output Text:
The aim of this study was to investigate whether autophagy was involved in the progression of heart failure induced by <span class="chemical">adriamycin</span> , so that we can develop a novel treatment strategy for heart failure . 