In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: MMP - 2 , MMP - 9 , ADAM - 10 and ADAM - 17 mRNA levels were increased in CaCl ( 2 ) - treated segments ( all p < 0 . 01 ) , with trends of elevation in CaCl ( 2 ) - untreated segments , as compared with NaCl - treated segments .
### Output Text:
MMP - 2 , MMP - 9 , ADAM - 10 and ADAM - 17 mRNA levels were increased in <span class="chemical">CaCl ( 2 )</span> - treated segments ( all p < 0 . 01 ) , with trends of elevation in <span class="chemical">CaCl ( 2 )</span> - untreated segments , as compared with <span class="chemical">NaCl</span> - treated segments . 