In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: METHODS : 3 - methyladenine ( 3MA ) , a specific inhibitor on autophagy was used in a heart failure model of rats induced by adriamycin .
### Output Text:
METHODS : <span class="chemical">3 - methyladenine</span> ( <span class="chemical">3MA</span> ) , a specific inhibitor on autophagy was used in a heart failure model of rats induced by <span class="chemical">adriamycin</span> . 