In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: METH depleted DA , caused microglial activation , and increased body temperature in CX3CR1 knockout mice to the same extent and over the same time course seen in wild - type controls .
### Output Text:
<span class="chemical">METH</span> depleted <span class="chemical">DA</span> , caused microglial activation , and increased body temperature in CX3CR1 knockout mice to the same extent and over the same time course seen in wild - type controls . 