In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: With last observations carried forward ( LOCF ) , mean Positive and Negative Syndrome Scale total score reductions from baseline to endpoint were significantly greater with asenapine at 5 mg BID ( - 16 . 2 ) and haloperidol ( - 15 . 4 ) than placebo ( - 10 . 7 ; both P < 0 . 05 ) ; using mixed model for repeated measures ( MMRM ) , changes at day 42 were significantly greater with asenapine at 5 and 10 mg BID ( - 21 . 3 and - 19 . 4 , respectively ) and haloperidol ( - 20 . 0 ) than placebo ( - 14 . 6 ; all P < 0 . 05 ) .
### Output Text:
With last observations carried forward ( LOCF ) , mean Positive and Negative Syndrome Scale total score reductions from baseline to endpoint were significantly greater with <span class="chemical">asenapine</span> at 5 mg BID ( - 16 . 2 ) and <span class="chemical">haloperidol</span> ( - 15 . 4 ) than placebo ( - 10 . 7 ; both P < 0 . 05 ) ; using mixed model for repeated measures ( MMRM ) , changes at day 42 were significantly greater with <span class="chemical">asenapine</span> at 5 and 10 mg BID ( - 21 . 3 and - 19 . 4 , respectively ) and <span class="chemical">haloperidol</span> ( - 20 . 0 ) than placebo ( - 14 . 6 ; all P < 0 . 05 ) . 