In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: TAKE HOME MESSAGE : Capecitabine is an oral prodrug of 5 - FU and was developed to fulfill the need for a more convenient therapy and provide an improved safety / efficacy profile .
### Output Text:
TAKE HOME MESSAGE : <span class="chemical">Capecitabine</span> is an oral prodrug of <span class="chemical">5 - FU</span> and was developed to fulfill the need for a more convenient therapy and provide an improved safety / efficacy profile . 