In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In cyclophosphamide - induced cystitis in the rat , detrusor function is impaired and the expression and effects of muscarinic receptors altered .
### Output Text:
In <span class="chemical">cyclophosphamide</span> - induced cystitis in the rat , detrusor function is impaired and the expression and effects of muscarinic receptors altered . 