In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Interestingly , all the drugs , such as , AAP , AMI and DOX induced apoptotic death in addition to necrosis in the respective organs which was very effectively blocked by GSPE .
### Output Text:
Interestingly , all the drugs , such as , <span class="chemical">AAP</span> , <span class="chemical">AMI</span> and <span class="chemical">DOX</span> induced apoptotic death in addition to necrosis in the respective organs which was very effectively blocked by <span class="chemical">GSPE</span> . 