In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Evaluation of adverse reactions of aponidine hydrochloride ophthalmic solution .
### Output Text:
Evaluation of adverse reactions of <span class="chemical">aponidine hydrochloride</span> ophthalmic solution . 