In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Early trials of cisplatin and amifostine also suggested that the incidence and severity of cisplatin - induced nephrotoxicity , ototoxicity , and neuropathy were reduced .
### Output Text:
Early trials of <span class="chemical">cisplatin</span> and <span class="chemical">amifostine</span> also suggested that the incidence and severity of <span class="chemical">cisplatin</span> - induced nephrotoxicity , ototoxicity , and neuropathy were reduced . 