In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: These defects explain the abnormal erythrocyte shape and decreased mechanical stability promoted by TAM , resulting in hemolytic anemia .
### Output Text:
These defects explain the abnormal erythrocyte shape and decreased mechanical stability promoted by <span class="chemical">TAM</span> , resulting in hemolytic anemia . 