In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: A Phase I study of intravenous ( IV ) bolus 4 ' - 0 - tetrahydropyranyladriamycin ( Pirarubicin ) was done in 55 patients in good performance status with refractory tumors .
### Output Text:
A Phase I study of intravenous ( IV ) bolus <span class="chemical">4 ' - 0 - tetrahydropyranyladriamycin</span> ( <span class="chemical">Pirarubicin</span> ) was done in 55 patients in good performance status with refractory tumors . 