In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Patients with a DBP reduction of > or = 20 % in the high - dose group had a significantly increased adjusted OR for the compound outcome variable death or dependency ( Barthel Index < 60 ) ( n / N = 25 / 26 , OR 10 . 16 , 95 % CI 1 . 02 to 101 . 74 ) and death alone ( n / N = 9 / 26 , OR 4 . 336 , 95 % CI 1 . 131 16 . 619 ) compared with all placebo patients ( n / N = 62 / 92 and 14 / 92 , respectively ) .
### Output Text:
Patients with a DBP reduction of > or = 20 % in the high - dose group had a significantly increased adjusted OR for the compound outcome variable death or dependency ( Barthel Index < 60 ) ( n / N = 25 / 26 , OR 10 . 16 , 95 % CI 1 . 02 to 101 . 74 ) and death alone ( n / N = 9 / 26 , OR 4 . 336 , 95 % CI 1 . 131 16 . 619 ) compared with all placebo patients ( n / N = 62 / 92 and 14 / 92 , respectively ) . 