In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Cardiotoxicity was defined as a reduction of the LVEF of > 5 % to < 55 % with symptoms of heart failure or an asymptomatic reduction of the LVEF of > 10 % to < 55 % .
### Output Text:
Cardiotoxicity was defined as a reduction of the LVEF of > 5 % to < 55 % with symptoms of heart failure or an asymptomatic reduction of the LVEF of > 10 % to < 55 % . 