In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Patients in the conventional group had statistically significant greater fall in the systolic blood pressures at 15 , 30 and 45 minutes when compared to the baseline ( P = 0 . 003 , 0 . 001 and 0 . 004 ) .
### Output Text:
Patients in the conventional group had statistically significant greater fall in the systolic blood pressures at 15 , 30 and 45 minutes when compared to the baseline ( P = 0 . 003 , 0 . 001 and 0 . 004 ) . 