In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: To our knowledge , this is the first published case report of severe neurotoxicity caused by nelarabine in a patient who received concurrent IT chemotherapy .
### Output Text:
To our knowledge , this is the first published case report of severe neurotoxicity caused by <span class="chemical">nelarabine</span> in a patient who received concurrent IT chemotherapy . 