In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Quantitative , real - time polymerase chain reaction also demonstrated significant increases ( P < or = 0 . 01 ) in p75 ( NTR ) mRNA in DRG with intermediate and chronic CYP - induced cystitis .
### Output Text:
Quantitative , real - time polymerase chain reaction also demonstrated significant increases ( P < or = 0 . 01 ) in p75 ( NTR ) mRNA in DRG with intermediate and chronic <span class="chemical">CYP</span> - induced cystitis . 