In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Clinically significant anemia ( hemoglobin < 7 g / dL ) was observed in 5 . 4 % of patients ( CD4 , 165 cells / microL ) and hepatitis ( clinical jaundice with alanine aminotransferase > 5 times upper limits of normal ) in 3 . 5 % of patients ( CD4 , 260 cells / microL ) .
### Output Text:
Clinically significant anemia ( hemoglobin < 7 g / dL ) was observed in 5 . 4 % of patients ( CD4 , 165 cells / microL ) and hepatitis ( clinical jaundice with <span class="chemical">alanine</span> aminotransferase > 5 times upper limits of normal ) in 3 . 5 % of patients ( CD4 , 260 cells / microL ) . 