In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Synthesis of cholate was reduced by 68 % in EE - treated rats , while that of chenodeoxycholate was increased by 60 % .
### Output Text:
Synthesis of <span class="chemical">cholate</span> was reduced by 68 % in <span class="chemical">EE</span> - treated rats , while that of <span class="chemical">chenodeoxycholate</span> was increased by 60 % . 