In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In the hepatocyte - specific ILK / liver - / - mice , the liver : body weight ratio was more than double as compared to 0 h at day 2 ( 2 . 5 times ) , while at days 5 and 10 , it was enlarged three times .
### Output Text:
In the hepatocyte - specific ILK / liver - / - mice , the liver : body weight ratio was more than double as compared to 0 h at day 2 ( 2 . 5 times ) , while at days 5 and 10 , it was enlarged three times . 