In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: BNPP ( 1 to 8 mM ) reduced APAP deacetylation and covalent binding in F344 renal cortical homogenates in a concentration - dependent manner .
### Output Text:
<span class="chemical">BNPP</span> ( 1 to 8 mM ) reduced <span class="chemical">APAP</span> deacetylation and covalent binding in F344 renal cortical homogenates in a concentration - dependent manner . 