In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Neurocognitive and neuroradiologic central nervous system late effects in children treated on Pediatric Oncology Group ( POG ) P9605 ( standard risk ) and P9201 ( lesser risk ) acute lymphoblastic leukemia protocols ( ACCL0131 ) : a methotrexate consequence ?
### Output Text:
Neurocognitive and neuroradiologic central nervous system late effects in children treated on Pediatric Oncology Group ( POG ) P9605 ( standard risk ) and P9201 ( lesser risk ) acute lymphoblastic leukemia protocols ( ACCL0131 ) : a <span class="chemical">methotrexate</span> consequence ? 