In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CONCLUSION : The data show that CCR2 and CCL2 are up - regulated in the hippocampus after pilocarpine - induced SE .
### Output Text:
CONCLUSION : The data show that CCR2 and CCL2 are up - regulated in the hippocampus after <span class="chemical">pilocarpine</span> - induced SE . 