In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: There is no evidence that systemic subtoxic bupivacaine administration enhances the dysrhythmogenicity of subsequent epinephrine .
### Output Text:
There is no evidence that systemic subtoxic <span class="chemical">bupivacaine</span> administration enhances the dysrhythmogenicity of subsequent <span class="chemical">epinephrine</span> . 