In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Thirty to 135 min after the injection of crystalline insulin , ISO was given subcutaneously and when ISO induced fibrosis in the myocardium was morphometrically analyzed 7 days later , a highly significant correlation ( r = 0 . 83 , 2 p = 0 . 006 ) to the slope of the fall in blood glucose after insulin treatment appeared .
### Output Text:
Thirty to 135 min after the injection of crystalline insulin , <span class="chemical">ISO</span> was given subcutaneously and when <span class="chemical">ISO</span> induced fibrosis in the myocardium was morphometrically analyzed 7 days later , a highly significant correlation ( r = 0 . 83 , 2 p = 0 . 006 ) to the slope of the fall in blood <span class="chemical">glucose</span> after insulin treatment appeared . 