In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Major bleeding with argatroban is 0 - 10 % in the non - interventional setting and 0 - 5 . 8 % periprocedurally .
### Output Text:
Major bleeding with <span class="chemical">argatroban</span> is 0 - 10 % in the non - interventional setting and 0 - 5 . 8 % periprocedurally . 