In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: We have recently demonstrated that disruption of extracellular matrix ( ECM ) / integrin signaling via elimination of integrin - linked kinase ( ILK ) in hepatocytes interferes with signals leading to termination of liver regeneration .
### Output Text:
We have recently demonstrated that disruption of extracellular matrix ( ECM ) / integrin signaling via elimination of integrin - linked kinase ( ILK ) in hepatocytes interferes with signals leading to termination of liver regeneration . 