In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Cardiac symptoms , including hypotension , developed in three patients with advanced colorectal carcinoma while being treated with cisplatin ( CDDP ) and 5 - fluorouracil ( 5 - FU ) .
### Output Text:
Cardiac symptoms , including hypotension , developed in three patients with advanced colorectal carcinoma while being treated with <span class="chemical">cisplatin</span> ( <span class="chemical">CDDP</span> ) and <span class="chemical">5 - fluorouracil</span> ( <span class="chemical">5 - FU</span> ) . 