In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CIN more frequently developed in patients who had undergone CT within 45 days after the last chemotherapy ( P = 0 . 005 ) ; it was also an independent risk factor ( P = 0 . 017 ) .
### Output Text:
CIN more frequently developed in patients who had undergone CT within 45 days after the last chemotherapy ( P = 0 . 005 ) ; it was also an independent risk factor ( P = 0 . 017 ) . 