In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Therefore , the BNPP - induced reduction in APAP - induced nephrotoxicity appears to be due to inhibition of APAP deacetylation .
### Output Text:
Therefore , the <span class="chemical">BNPP</span> - induced reduction in <span class="chemical">APAP</span> - induced nephrotoxicity appears to be due to inhibition of <span class="chemical">APAP</span> deacetylation . 