In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: After applying topical glycopyrrolate , the subjective effect was excellent ( no sweating after eating hot spicy food ) in 10 patients ( 77 % ) , and fair ( clearly reduced sweating ) in 3 patients ( 23 % ) .
### Output Text:
After applying topical <span class="chemical">glycopyrrolate</span> , the subjective effect was excellent ( no sweating after eating hot spicy food ) in 10 patients ( 77 % ) , and fair ( clearly reduced sweating ) in 3 patients ( 23 % ) . 