In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: There were 53 major hemorrhages , for an annual rate of 10 . 0 % , including 24 ( 45 . 3 % ) life - threatening and five ( 9 . 4 % ) fatal bleeds .
### Output Text:
There were 53 major hemorrhages , for an annual rate of 10 . 0 % , including 24 ( 45 . 3 % ) life - threatening and five ( 9 . 4 % ) fatal bleeds . 