In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The effects of helodermin , a basic 35 - amino acid peptide isolated from the venom of a lizard salivary gland , on arterial blood pressure and heart rate were examined in the rat , focusing on the possibility that activation of ATP sensitive K + ( K ( ATP ) ) channels is involved in the responses .
### Output Text:
The effects of <span class="chemical">helodermin</span> , a basic 35 - <span class="chemical">amino acid</span> peptide isolated from the venom of a lizard salivary gland , on arterial blood pressure and heart rate were examined in the rat , focusing on the possibility that activation of <span class="chemical">ATP</span> sensitive <span class="chemical">K</span> + ( <span class="chemical">K</span> ( <span class="chemical">ATP</span> ) ) channels is involved in the responses . 