In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: ( + ) - Propranolol had no effect on fatty acid mobilization but significantly reduced the increments in both lactate and glucose . 4 .
### Output Text:
( + ) - <span class="chemical">Propranolol</span> had no effect on <span class="chemical">fatty acid</span> mobilization but significantly reduced the increments in both <span class="chemical">lactate</span> and <span class="chemical">glucose</span> . 4 . 