In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: It is likely that preexisting renal disease predisposed this patient to type IV renal tubular acidosis with prostaglandin synthetase inhibitors .
### Output Text:
It is likely that preexisting renal disease predisposed this patient to type IV renal tubular acidosis with <span class="chemical">prostaglandin</span> synthetase inhibitors . 