In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Not only treatment of their infections but also the overall poor health of the patients and increased risk of noncompliance need to be addressed .
### Output Text:
Not only treatment of their infections but also the overall poor health of the patients and increased risk of noncompliance need to be addressed . 