In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: BACKGROUND : Focal subtenon carboplatin injections have recently been used as a presumably toxicity - free adjunct to systemic chemotherapy for intraocular retinoblastoma .
### Output Text:
BACKGROUND : Focal subtenon <span class="chemical">carboplatin</span> injections have recently been used as a presumably toxicity - free adjunct to systemic chemotherapy for intraocular retinoblastoma . 