In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: BACKGROUND : The aim of the study was to investigate the antihypertensive effects of angiotensin II type - 1 receptor blocker , losartan , and its potential in slowing down renal disease progression in spontaneously hypertensive rats ( SHR ) with adriamycin ( ADR ) nephropathy .
### Output Text:
BACKGROUND : The aim of the study was to investigate the antihypertensive effects of <span class="chemical">angiotensin II</span> type - 1 receptor blocker , <span class="chemical">losartan</span> , and its potential in slowing down renal disease progression in spontaneously hypertensive rats ( SHR ) with <span class="chemical">adriamycin</span> ( <span class="chemical">ADR</span> ) nephropathy . 