In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Carvedilol also prevented the decrease in mitochondrial Ca ( 2 + ) loading capacity and the inhibition of the respiratory complexes of heart mitochondria caused by doxorubicin .
### Output Text:
<span class="chemical">Carvedilol</span> also prevented the decrease in mitochondrial <span class="chemical">Ca</span> ( 2 + ) loading capacity and the inhibition of the respiratory complexes of heart mitochondria caused by <span class="chemical">doxorubicin</span> . 