In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Pilocarpine produced neuronal death in the hippocampus , which showed pyknotic changes .
### Output Text:
<span class="chemical">Pilocarpine</span> produced neuronal death in the hippocampus , which showed pyknotic changes . 