In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CONCLUSION : Losartan reduces the rate of progression of ADR - induced focal segmental glomerulosclerosis to end - stage renal disease in SHR .
### Output Text:
CONCLUSION : <span class="chemical">Losartan</span> reduces the rate of progression of <span class="chemical">ADR</span> - induced focal segmental glomerulosclerosis to end - stage renal disease in SHR . 