In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In cells stained with fluorescent dyes targeting lysosomes , CAA induced an increase in lysosomal size and lysosomal leakage .
### Output Text:
In cells stained with fluorescent dyes targeting lysosomes , <span class="chemical">CAA</span> induced an increase in lysosomal size and lysosomal leakage . 