In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Etoposide ( VP - 16 - 213 ) has been used in the treatment of many solid tumors and hematologic malignancies .
### Output Text:
<span class="chemical">Etoposide</span> ( <span class="chemical">VP - 16 - 213</span> ) has been used in the treatment of many solid tumors and hematologic malignancies . 