In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: It appears that temocapril was effective in retarding renal progression and protected renal function in PAN neprotic rats .
### Output Text:
It appears that <span class="chemical">temocapril</span> was effective in retarding renal progression and protected renal function in <span class="chemical">PAN</span> neprotic rats . 