In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Molecular dynamic ( MD ) simulations showed that the overall effect of the mutation p . Val204Asp is disruption of hydrogen bonding between Gln223 and Glu441 , leading Ser198 and His438 to move away from each other with subsequent disruption of the catalytic triad functionality regardless of the type of substrate .
### Output Text:
Molecular dynamic ( MD ) simulations showed that the overall effect of the mutation p . Val204Asp is disruption of <span class="chemical">hydrogen</span> bonding between Gln223 and Glu441 , leading Ser198 and His438 to move away from each other with subsequent disruption of the catalytic triad functionality regardless of the type of substrate . 