In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Efficacy and safety of granisetron , a selective 5 - hydroxytryptamine - 3 receptor antagonist , in the prevention of nausea and vomiting induced by high - dose cisplatin .
### Output Text:
Efficacy and safety of <span class="chemical">granisetron</span> , a selective <span class="chemical">5 - hydroxytryptamine</span> - 3 receptor antagonist , in the prevention of nausea and vomiting induced by high - dose <span class="chemical">cisplatin</span> . 