In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CONCLUSION : A single 10 - , 20 - , or 40 - micrograms / kg dose of granisetron was effective in controlling vomiting in 57 % to 60 % of patients who received cisplatin at doses greater than 81 mg / m2 and totally prevented vomiting in 40 % to 47 % of patients .
### Output Text:
CONCLUSION : A single 10 - , 20 - , or 40 - micrograms / kg dose of <span class="chemical">granisetron</span> was effective in controlling vomiting in 57 % to 60 % of patients who received <span class="chemical">cisplatin</span> at doses greater than 81 mg / m2 and totally prevented vomiting in 40 % to 47 % of patients . 