In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: However , the population has never been quantified , so it is unclear whether it is substantial enough to have a strong influence on epileptogenesis .
### Output Text:
However , the population has never been quantified , so it is unclear whether it is substantial enough to have a strong influence on epileptogenesis . 