In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Coadministration of carvedilol decreased the extent of cellular vacuolization in cardiac myocytes and prevented the inhibitory effect of doxorubicin on mitochondrial respiration in both heart and liver .
### Output Text:
Coadministration of <span class="chemical">carvedilol</span> decreased the extent of cellular vacuolization in cardiac myocytes and prevented the inhibitory effect of <span class="chemical">doxorubicin</span> on mitochondrial respiration in both heart and liver . 