In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The patient began to have changes in white blood cells and platelets within 48 h of administration of fluconazole and began to recover with 48 h of discontinuation .
### Output Text:
The patient began to have changes in white blood cells and platelets within 48 h of administration of <span class="chemical">fluconazole</span> and began to recover with 48 h of discontinuation . 