In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In this study , we explored the importance of pathological Ca ( 2 + ) signaling in aconitine poisoning in vitro and in vivo .
### Output Text:
In this study , we explored the importance of pathological <span class="chemical">Ca</span> ( 2 + ) signaling in <span class="chemical">aconitine</span> poisoning in vitro and in vivo . 