In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Misoprostol ( 200 micrograms ) has been shown to acutely counteract the indomethacin - induced renal dysfunction in well compensated cirrhotic patients .
### Output Text:
<span class="chemical">Misoprostol</span> ( 200 micrograms ) has been shown to acutely counteract the <span class="chemical">indomethacin</span> - induced renal dysfunction in well compensated cirrhotic patients . 