In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The isovolumic relaxation period was prolonged 45 minutes after each form of stress ( p < 0 . 05 ) .
### Output Text:
The isovolumic relaxation period was prolonged 45 minutes after each form of stress ( p < 0 . 05 ) . 