In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Furthermore , there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc .
### Output Text:
Furthermore , there have been reports of thrombotic microangiopathy precipitated by <span class="chemical">cyclosporine</span> in patients with SSc . 