In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Both the precordial pain and the electrocardiographic changes disappeared spontaneously after the discontinuation of 5 - FU .
### Output Text:
Both the precordial pain and the electrocardiographic changes disappeared spontaneously after the discontinuation of <span class="chemical">5 - FU</span> . 