In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The studies were performed using an experimental model of isoproterenol - induced heart hypertrophy in rats .
### Output Text:
The studies were performed using an experimental model of <span class="chemical">isoproterenol</span> - induced heart hypertrophy in rats . 