In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Aconitine - induced Ca2 + overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats .
### Output Text:
<span class="chemical">Aconitine</span> - induced <span class="chemical">Ca2</span> + overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats . 