In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In particular the temporal relationship of bone marrow suppression to the initiation of fluconazole and the abatement of symptoms that rapidly reversed immediately following discontinuation .
### Output Text:
In particular the temporal relationship of bone marrow suppression to the initiation of <span class="chemical">fluconazole</span> and the abatement of symptoms that rapidly reversed immediately following discontinuation . 