In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Losartan reduced uraemia and increased urea clearance in advanced ADR nephropathy in SHR .
### Output Text:
<span class="chemical">Losartan</span> reduced uraemia and increased <span class="chemical">urea</span> clearance in advanced <span class="chemical">ADR</span> nephropathy in SHR . 