In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In aspartate , glutamine and glutamate levels detected a decrease of 5 . 21 % , 13 . 55 % and 21 . 80 % , respectively in mice hippocampus treated with GFC75 plus P400 when compared with seized mice .
### Output Text:
In <span class="chemical">aspartate</span> , <span class="chemical">glutamine</span> and <span class="chemical">glutamate</span> levels detected a decrease of 5 . 21 % , 13 . 55 % and 21 . 80 % , respectively in mice hippocampus treated with GFC75 plus P400 when compared with seized mice . 