In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Since chemotherapeutic agent toxicity generally correlates with dose per body surface area , we retrospectively calculated the dose of CYA in patients transplanted at our institution to determine whether the incidence of CYA cardiotoxicity correlated with the dose per body surface area .
### Output Text:
Since chemotherapeutic agent toxicity generally correlates with dose per body surface area , we retrospectively calculated the dose of <span class="chemical">CYA</span> in patients transplanted at our institution to determine whether the incidence of <span class="chemical">CYA</span> cardiotoxicity correlated with the dose per body surface area . 