In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CIN was significantly more after treatment with bevacizumab / irinotecan ( P = 0 . 021 ) and in patients with hypertension ( P = 0 . 044 ) .
### Output Text:
CIN was significantly more after treatment with <span class="chemical">bevacizumab</span> / <span class="chemical">irinotecan</span> ( P = 0 . 021 ) and in patients with hypertension ( P = 0 . 044 ) . 