In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Acute renal toxicity of doxorubicin ( adriamycin ) - loaded cyanoacrylate nanoparticles .
### Output Text:
Acute renal toxicity of <span class="chemical">doxorubicin</span> ( <span class="chemical">adriamycin</span> ) - loaded <span class="chemical">cyanoacrylate</span> nanoparticles . 