In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CONCLUSION : We suggest that interactions between NO and apoptosis are important in the pathogenesis of the ADR - induced nephrosis .
### Output Text:
CONCLUSION : We suggest that interactions between <span class="chemical">NO</span> and apoptosis are important in the pathogenesis of the <span class="chemical">ADR</span> - induced nephrosis . 