In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: qRT - PCR detected similar patterns of changes in AQP2 mRNA in the medulla but not in the cortex .
### Output Text:
qRT - PCR detected similar patterns of changes in AQP2 mRNA in the medulla but not in the cortex . 