In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: These data suggest that the hepatic and extrahepatic Ao mRNA levels are unaltered during the development of the acute NS induced by PAN .
### Output Text:
These data suggest that the hepatic and extrahepatic Ao mRNA levels are unaltered during the development of the acute NS induced by <span class="chemical">PAN</span> . 