In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In patients with OAB urinary PGE2 positively correlated with volume at first desire to void and maximum cystometric capacity ( p < 0 . 05 ) .
### Output Text:
In patients with OAB urinary <span class="chemical">PGE2</span> positively correlated with volume at first desire to void and maximum cystometric capacity ( p < 0 . 05 ) . 