In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Reserpine treated rats significantly developed vacuous chewing movements and tongue protrusions however , coadministration of Hibiscus rosa sinensis roots extract ( 100 , 200 and 300 mg / kg , per orally ) attenuated the effects .
### Output Text:
<span class="chemical">Reserpine</span> treated rats significantly developed vacuous chewing movements and tongue protrusions however , coadministration of <span class="chemical">Hibiscus rosa sinensis</span> roots extract ( 100 , 200 and 300 mg / kg , per orally ) attenuated the effects . 