In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Subcutaneous injection of ISPH ( 200 mg / kg body weight in 1 ml saline ) to rats for 2 consecutive days caused myocardial damage in rat heart , which was determined by the increased activity of serum lactate dehydrogenase ( LDH ) and creatine phosphokinase isoenzymes ( CK - MB ) , increased uric acid level and reduced plasma iron binding capacity .
### Output Text:
Subcutaneous injection of <span class="chemical">ISPH</span> ( 200 mg / kg body weight in 1 ml saline ) to rats for 2 consecutive days caused myocardial damage in rat heart , which was determined by the increased activity of serum <span class="chemical">lactate</span> dehydrogenase ( LDH ) and <span class="chemical">creatine</span> phosphokinase isoenzymes ( CK - MB ) , increased <span class="chemical">uric acid</span> level and reduced plasma <span class="chemical">iron</span> binding capacity . 