In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The role of cyclosporine ( CSA ) alone or in combination with various chemotherapeutics in the development of renal toxicity was evaluated in rats .
### Output Text:
The role of <span class="chemical">cyclosporine</span> ( <span class="chemical">CSA</span> ) alone or in combination with various chemotherapeutics in the development of renal toxicity was evaluated in rats . 