In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Local anesthetics that are commonly used in ophthalmic surgery ( 0 . 75 % bupivacaine hydrochloride , 2 . 0 % mepivacaine hydrochloride , and 2 . 0 % lidocaine hydrochloride plus 1 : 100 , 000 epinephrine ) were injected into the retrobulbar area of rat eyes .
### Output Text:
Local anesthetics that are commonly used in ophthalmic surgery ( 0 . 75 % <span class="chemical">bupivacaine hydrochloride</span> , 2 . 0 % <span class="chemical">mepivacaine hydrochloride</span> , and 2 . 0 % <span class="chemical">lidocaine hydrochloride</span> plus 1 : 100 , 000 <span class="chemical">epinephrine</span> ) were injected into the retrobulbar area of rat eyes . 