In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: This agent inhibits Urd catabolism and , in vivo , increases the plasma concentration of Urd in a dose - dependent manner , without Urd - related toxicity .
### Output Text:
This agent inhibits <span class="chemical">Urd</span> catabolism and , in vivo , increases the plasma concentration of <span class="chemical">Urd</span> in a dose - dependent manner , without <span class="chemical">Urd</span> - related toxicity . 