In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Activities of heart tissue enzymic antioxidants and serum non - enzymic antioxidants levels rose significantly upon mangiferin administration as compared to ISPH - induced MI rats .
### Output Text:
Activities of heart tissue enzymic antioxidants and serum non - enzymic antioxidants levels rose significantly upon <span class="chemical">mangiferin</span> administration as compared to <span class="chemical">ISPH</span> - induced MI rats . 