In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Effect of some convulsants on the protective activity of loreclezole and its combinations with valproate or clonazepam in amygdala - kindled rats .
### Output Text:
Effect of some convulsants on the protective activity of <span class="chemical">loreclezole</span> and its combinations with <span class="chemical">valproate</span> or <span class="chemical">clonazepam</span> in amygdala - kindled rats . 