In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: In the IPRK phenylephrine and acetylcholine related responses were significantly impaired in the ADR - nephropathy group .
### Output Text:
In the IPRK <span class="chemical">phenylephrine</span> and <span class="chemical">acetylcholine</span> related responses were significantly impaired in the <span class="chemical">ADR</span> - nephropathy group . 