In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: Cumulative doses of doxorubicin were 225 - 550 mg / m2 ( median dose 360 ) .
### Output Text:
Cumulative doses of <span class="chemical">doxorubicin</span> were 225 - 550 mg / m2 ( median dose 360 ) . 