In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: These findings suggest that B1R is detrimental in DOX cardiomyopathy in that it mediates the inflammatory response and apoptosis .
### Output Text:
These findings suggest that B1R is detrimental in <span class="chemical">DOX</span> cardiomyopathy in that it mediates the inflammatory response and apoptosis . 