In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: BACKGROUND : The aim of this study is to evaluate the effects of RAPA conversion in patients undergoing cyclosporine ( CsA ) or tacrolimus ( Tac ) toxicity .
### Output Text:
BACKGROUND : The aim of this study is to evaluate the effects of <span class="chemical">RAPA</span> conversion in patients undergoing <span class="chemical">cyclosporine</span> ( <span class="chemical">CsA</span> ) or <span class="chemical">tacrolimus</span> ( <span class="chemical">Tac</span> ) toxicity . 