In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: The development of cardiac hypertrophy was studied in adult female Wistar rats following daily subcutaneous injections of isoproterenol ( ISO ) ( 0 . 3 mg / kg body weight ) .
### Output Text:
The development of cardiac hypertrophy was studied in adult female Wistar rats following daily subcutaneous injections of <span class="chemical">isoproterenol</span> ( <span class="chemical">ISO</span> ) ( 0 . 3 mg / kg body weight ) . 