In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: OBJECTIVES : To evaluate extrapyramidal symptoms ( EPS ) , including akathisia , with quetiapine in patients with bipolar mania .
### Output Text:
OBJECTIVES : To evaluate extrapyramidal symptoms ( EPS ) , including akathisia , with <span class="chemical">quetiapine</span> in patients with bipolar mania . 