In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: From the present study it is concluded that mangiferin exerts a beneficial effect against ISPH - induced MI due to its antioxidant potential , which regulated the tissues defense system against cardiac damage .
### Output Text:
From the present study it is concluded that <span class="chemical">mangiferin</span> exerts a beneficial effect against <span class="chemical">ISPH</span> - induced MI due to its antioxidant potential , which regulated the tissues defense system against cardiac damage . 