In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: CONCLUSIONS : In bipolar mania , the incidence of EPS , including akathisia , with quetiapine therapy is similar to that with placebo .
### Output Text:
CONCLUSIONS : In bipolar mania , the incidence of EPS , including akathisia , with <span class="chemical">quetiapine</span> therapy is similar to that with placebo . 