In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.

### Input Text: We have compared , in 60 adult patients , the cardiovascular effects of glycopyrronium 5 micrograms kg - 1 and 10 micrograms kg - 1 given either simultaneously or 1 min before edrophonium 1 mg kg - 1 .
### Output Text:
We have compared , in 60 adult patients , the cardiovascular effects of <span class="chemical">glycopyrronium</span> 5 micrograms kg - 1 and 10 micrograms kg - 1 given either simultaneously or 1 min before <span class="chemical">edrophonium</span> 1 mg kg - 1 . 