Atropoenantioselective palladaelectro-catalyzed anilide C–H olefinations viable with natural sunlight as sustainable power source

Enantioselective electrocatalyzed transformations represent a major challenge. We herein achieved atropoenantioselective pallada-electrocatalyzed C–H olefinations and C–H allylations with high efficacy and enantioselectivity under exceedingly mild reaction conditions. With (S)-5-oxoproline as the chiral ligand, activated and non-activated olefins were suitable substrates for the electro-C–H activations. Dual catalysis was devised in terms of electro-C–H olefination, along with catalytic hydrogenation. Challenging enantiomerically-enriched chiral anilide scaffolds were thereby obtained with high levels of enantio-control in the absence of toxic and cost-intensive silver salts. The resource-economy of the transformation was even improved by directly employing renewable solar energy.


Introduction
Organic electrochemistry has recently emerged as a transformative platform in molecular syntheses, 1 enabling the use of electrons as sustainable redox reagents within electron-catalysis manifolds. 2 Regio-and chemo-selective transformations have thus been accomplished by dialling in the appropriate electrolysis potential. However, despite recent advances in asymmetric electrochemistry, 3 enantioselective electrocatalysis continues to be scarce. This can be ascribed to key challenges, such as electrochemical degradation of the catalyst or of the chiral ligand, while unfavourable interactions of the electrolyte within the enantio-determining transition state need to be fully controlled to achieve full selectivity control.
Chiral axis represent key scaffolds in natural products, biologically active compounds, chiral ligands and functional materials. 4 Particularly, biaryls are omnipresent and their syntheses have been accomplished by means of cross-coupling, arene assembly and the functionalization of racemic or prochiral biaryls, among others. 5 In sharp contrast, the asymmetric assembly of molecules bearing an acyclic anilide motif with axial chirality has arguably received signicantly less attention. 6 As this structural moiety has a greater degree of rotational freedom than have biaryls, the control of the enantioselectivity is considerably more difficult. Thus, exceedingly mild reaction conditions are required to ensure effective chiral induction, as well as to warrant the atropostability of the thus-obtained products. In this regard, Curran and Taguchi have made pioneering contributions towards the efficient catalytic asymmetric synthesis of such compounds. 7 The efficiency of the enantioinduction was improved by inter alia nitrogen-functionalizations, 8 cycloadditions for arene construction, 9 organocatalytic nucleophilic additions 10 or C-H functionalizations by dynamic kinetic resolution, with major advances by Shi. 11 Contrasting with this indisputable progress, these strategies suffer from the use of prefunctionalized substrates orin the latter case of C-H activationsfrom stoichiometric amounts of expensive and toxic strong silver(I) chemical oxidants, giving rise to undesirable by-products in stoichiometric quantities. This signicantly compromises the resource-economy of the overall strategy. 12 In this context, we very recently reported on the asymmetric metalla-electrocatalyzed C-H activation enabled by a transient directing group, that is through substrate controlled selectivity. 13 In sharp contrast, we have now developed a strategy for asymmetric electrocatalysis via electro-catalyst control to access synthetically-meaningful axially-chiral anilides by electro-oxidative palladium(II)-catalyzed C-H activation (Fig. 1). Hence, dynamic kinetic resolution provided access to a wide range of chiral anilides with a readily available and inexpensive chiral ligand, featuring outstanding levels of resource-economy, electricity as the sacricial oxidant, and molecular hydrogen as the only by-product.

Results and discussion
Optimisation We initiated our studies by probing the enantioselective C-H olenation of N-benzyl-N-(2-isopropylphenyl)picolinamide (1a) with tert-butyl acrylate (2a). We were pleased to note that under a 4.0 mA constant current electrolysis (CCE), the expected product 3aa could be isolated in 11% yield and with 78% ee (Table 1, entry 2). 14 The use of catalytic amounts of the redoxmediator 15 1,4-benzoquinone (BQ) proved to be benecial to improve the efficacy, to give the product 3aa in 78% yield and with 97% ee (entries 3-6), which is likely due to a stabilization of palladium(0) species. The catalysis was efficient both under air or under a nitrogen atmosphere (entries 3 and 7). Addition of an electrolyte did not affect the reaction outcome (entry 8). At 60 C, the enantioselectivity of the reaction remained unchanged (entry 1). However, a slight decrease in enantioselectivity was found at an elevated temperature of 70 C and an increased current of 6 mA (entry 9). At 60 C, increasing the current to 6 mA did not alter the asymmetric olenation (entry 10), yet a lower current decreased the yield signicantly (entry 11).
The efficiency of the electrocatalysis dropped when using a divided cell setup (entry 12). Finally, we noted that the reaction also proceeded in a constant potential electrolysis (CPE) mode and a high efficiency and very good enantioselectivity was observed at 0.4 V (entries 13 and 14). Control experiments conrmed the essential role of the electricity and the palladium catalyst. 14

Robustness
With the optimized electrocatalysis conditions in hand, we next studied the scope of the atropoenantioselective C-H olenation of anilides 1 (Scheme 1). First, we explored the reaction of different olenic partners 2. Various acrylates 2a-2c proved thereby amenable to obtain products 3 with excellent enantioselectivities. Vinyl-ketones 2d and tertiary or secondary amides 2e and 2i were well-tolerated, as were styrenes 2f and 2g. Fluorinated styrene 2g allowed to access the expected product 3ag in 65% yield and with 94% ee. Vinyl phosphonates 2h could successfully be used likewise. Olens derived from natural products, such as menthol (2j) or linalool (2k), were also very well-tolerated.
3am were obtained respectively, reecting the robust scope of the pallada-electrocatalysis (Scheme 2). Non-activated alkenes 1-octene (2n) and 9-decen-1-ol (2o) were also identied as suitable substrates for the enantioselective pallada-electrocatalysis. Here, subsequent stirring of the electrocatalysis mixture under an atmosphere of hydrogen provided access to the alkylated products 3an and 3ao with high enantioselectivities (Scheme 3). The mild nature of the palladaelectro-catalyzed C-H functionalization was reected by the full tolerance of the free hydroxyl group in substrate 2o.
Third, various N-substituted anilides 1b-h were tested in the electrocatalytic asymmetric C-H olenation. Replacing the isopropyl ortho-substituent by a naphthyl group gave the Scheme 1 Scope of the reaction regarding the olefin partner.

Scheme 3 Dual electrocatalysis and hydrogenation manifold.
Scheme 4 Scope of the reaction regarding the anilide partner. desired product 3ia in 65% yield and 88% ee, while a methyl group led to a slight decrease in the enantioselectivity. However, by lowering the electrocatalysis temperature to 40 C, we achieved a high enantioselectivity. Both electron-donating and electron-withdrawing groups were well tolerated on the pyridine motif, as was evidenced by the successful use of the anilides 1ko (Scheme 4).
To signicantly improve the resource-economy 12 of our strategy, we next performed the constant current electrolysis solely powered by renewable solar energy. 16 To this end, we employed commercially available photovoltaic cells as the only power supply, guaranteeing high activity and enantioselectivity, when directly using natural sunlight (Scheme 5).

Mechanistic studies
Finally, we became interested in unravelling the mode of action of the asymmetric pallada-electrocatalysis. Given that bimetallic Pd-Ag or Ag-Ag species have previously been suggested to facilitate the C-H activations, 17 we hypothesized whether electrocatalysis would not only improve the sustainability, but also change the nature of the rate-determining step. In line with this hypothesis, a kinetic isotope effect (KIE) of k H /k D z 1.3 was suggestive of a fast C-H metalation step (Scheme 6a), 14 contrasting with a KIE of 2.3 when employing silver(I) oxidants. 11b Qualitative in operando infrared spectroscopy allowed us to unravel a short induction period (Scheme 6b). 14 Furthermore, we performed detailed studies by means of cyclic voltammetry (Scheme 6c). 14 Thus, we observed a decrease of the onset oxidation potential in the presence of BQ, indicating its bene-cial effect on the anodic oxidation. Thus, the BQ is proposed to serve a dual role, namely as a redox mediator as well as a ligand to stabilize palladium(0) species. A current dependence was next explored within a range from 1.0 to 6.0 mA (Scheme 6d). These ndings were indicative of the electron transfer step being the rate limiting step, with a plateau being reached above 4.0 mA.

Conclusions
We have reported on unprecedented catalyst-controlled atroposelective pallada-electrocatalyzed C-H activations, which provide access to synthetically-meaningful chiral anilides without stoichiometric amount of chemical oxidants. 1,4-Benzoquinone was identied as the catalytic redox-mediator of choice, with molecular hydrogen as the only stoichiometric byproduct. Thereby, an electrochemical degradation of the palladium catalyst could be avoided with sodium acetate as additive, serving both as a base and as an electrolyte without altering the enantioselectivity. Overall, we accessed enantioenriched Scheme 5 Renewable solar energy for atroposelective C-H olefinations.

Scheme 6
Key mechanistic experiments. Cyclic voltammetry measurements were recorded in TFE/DME (1/1) at a substrate concentration of 5.0 mM and with 0.1 M n-Bu 4 NPF 6 as supporting electrolyte. The scan rate is 100 mV s À1 . 14 anilides with high levels of enantioselectivity under exceedingly mild reaction conditions. Dual catalysis proved to be likewise viable, allowing electrocatalyzed C-H olenation, along with subsequent hydrogenation. The asymmetric electrocatalysis employed electricity as a sustainable oxidant, and could even be carried out using a commercial solar panel with natural sunlight as the sole power source.

Data availability
All experimental data, procedures for data analysis and pertinent data sets are provided in the ESI. †

Author contributions
J. F. and L. A. conceived the project, J. F. and X. H. performed the experiments, X. H. performed CV studies. J. F. and L. A. wrote the manuscript.

Conflicts of interest
There are no conicts to declare.