Iridium-catalyzed asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines

The development of the first asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines is reported. Utilizing [Ir(cod)Cl]2 and a commercially available chiral Josiphos ligand, a variety of differentially substituted isoquinolines are hydrogenated to produce enantioenriched trans-tetrahydroisoquinolines in good yield with high levels of enantioselectivity. Directing group studies demonstrate that the hydroxymethyl functionality at the C1 position is critical for hydrogenation to favor the trans-diastereomer. Preliminary mechanistic studies reveal that non-coordinating chlorinated solvents and halide additives are crucial to enable trans-selectivity.


Introduction
The asymmetric hydrogenation of heteroarenes has recently emerged as a powerful strategy to directly access enantioenriched, saturated heterocycles. 1,2 While signicant progress has been made in this eld, controlling selectivity in the formation of multiple stereocenters in a single reaction remains challenging. Transition metal-catalyzed hydrogenation of arenes typically proceeds through initial dearomative reduction of the substrate and subsequent rapid hydrogenation, resulting in high cis-selectivity of product (Fig. 1A, path A). 3,4 In contrast, accessing the trans-isomer requires a p-facial exchange of the arene to allow hydride delivery from the more sterically hindered face, rendering its synthesis signicantly more difficult (Fig. 1A, path B). While several reports describe the transselective hydrogenation of arenes, most are limited in scope and not enantioselective. 5,6 Considering the synthetic value of transsubstituted saturated heterocycles, a general method for an asymmetric trans-selective hydrogenation of heteroarenes would be a highly desirable and powerful strategy. 7, 8 Recently, our group has reported the asymmetric hydrogenation of 1,3-disubstituted isoquinolines to access enantioenriched cis-1,2,3,4-tetrahydroisoquinolines (THIQs). 9 This method enables the asymmetric hydrogenation of isoquinolines with Lewis basic functionalities, such as primary alcohols and heteroaryl-substituted isoquinolines, that signicantly expanded the scope of the transformation compared to prior reports. 10 During the course of this investigation, we also observed formation of the trans-THIQ under certain conditions in excellent enantioselectivity, albeit in small amounts. Herein, we disclose our efforts to develop the rst examples of an asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines to access enantioenriched trans-THIQs (Fig. 1B).

Results and discussion
We began our studies with 1-(hydroxymethyl)-3phenylisoquinoline (1a) as a model substrate. An initial experiment employing 1.25 mol% of [Ir(cod)Cl] 2 , 3 mol% of chiral Josiphos ligand L1, and 7.5 mol% of TBAI in THF delivered the THIQ product with high cis-selectivity (Table 1, entry 1). 8 We observed that using CH 2 Cl 2 as solvent gave higher levels of diastereoselectivity for trans-isomer 2a, with excellent enantioselectivity as well (97% ee, entry 2). 11 Gratied by this result, we explored different additives and observed that smaller halides afforded higher levels of the desired diastereoselectivity, albeit with diminished conversions of 1a. Overall, TBABr provided the best combination of diastereo-and enantioselectivity (Table S1 †). Other additives such as TBAPF 6 previously investigated by Pfaltz and co-workers completely shut down the reaction, demonstrating that halide salts were crucial for this transformation (entry 5). 12 Seeking to improve the diastereoselectivity, we surveyed a variety of chiral ligand scaffolds and found the xyliphos ligand framework to be optimal (Table S2 †). We observed that more electron-rich aryl groups on the chiral ligand provided the transproduct with higher selectivity, with the DMM-substituted phosphine L1 affording the highest diastereoselectivity of 2 : 1 trans : cis (entry 3 vs. entries 6-9). In contrast, more electronwithdrawing aryl groups such as L5 favored the formation of the cis-product (entry 9).
Having identied L1 as the optimal ligand, we briey investigated different solvents. We observed that noncoordinating chlorinated solvents such as chloroform and 1,2dichloroethane delivered product 2a with the highest transselectivity (entries 12-13), while non-chlorinated solvents toluene and ethyl acetate gave nearly a 1 : 1 diastereomeric ratio (entries 10-11). 13 We also explored different directing groups at the C1 position to probe their effects on the diastereoselectivity of this reaction. Isoquinolines bearing functionalities such as a methyl ether, benzyl ether or acetate substituent (3a-c) solely provided the cis-THIQ, suggesting that they are not functioning as directing groups in the reaction (Table 1, entries 14-16). Indeed, the hydrogenation of isoquinoline 3d that lacks any potential directing group also afforded only the cis-diastereomer of product (entry 17). While Boc-protected amine 3e provided the product in 1.4 : 1 dr favoring the trans-THIQ, basic amine functionalities such as primary amine 3f gave trace product, potentially due to catalyst deactivation (entry 19). Nevertheless, the investigation of different directing groups demonstrates that the hydroxyl functionality serves as the best directing group to selectively access the trans-diastereomer by enabling p-facial exchange of the substrate and facilitating hydride delivery from the more sterically hindered face via a directed hydrogenation. With optimized reaction conditions identied, we explored the substrate scope of this transformation ( Table 2). Due to the inseparable nature of the cis-and trans-diastereomers of the hydrogenated products, the crude reaction mixture was subsequently treated with 1,1 0 -carbonyldiimidazole (CDI) to afford the oxazolidinone-fused THIQs that were easily separable by column chromatography. From 5a, the relative and absolute stereochemistry of the trans-THIQ product was conrmed by Xray crystallography. 14 Gratifyingly, a wide variety of aryl substituents at the 3position of the isoquinoline were well tolerated, selectively yielding the trans-product in moderate to excellent ee. 15 Substitution at the para-position of the 3-aryl ring delivered hydrogenated products 5b-5g in high selectivities, ranging from electron-rich substrates 5b-5c to more electron-withdrawing substrates 5d-5f. Sterically encumbered substrates such as 3naphthyl, 3-xylyl isoquinolines also afforded products 5h-5i in good isolated yields, with slightly diminished enantioselectivity. Furthermore, the nitrile functional group in 5f and naphthyl substituent of 5h were not reduced in this process, highlighting the chemoselectivity of this transformation.
Additionally, we were pleased to observe that heteroarylsubstituted isoquinolines were well tolerated at 60 C and 60 bar H 2 to produce trans-THIQs 5k,l in high enantioselectivities (97% and 94% ee, respectively), and with no erosion of diastereoselectivity. Finally, different electronics of the isoquinoline carbocycle such as uorinated isoquinolines 1m-n were hydrogenated to afford electron-poor THIQs 5m-n in high selectivities under our standard conditions.
Having demonstrated that this transformation is general for a wide range of 1,3-disubstituted isoquinolines, we sought to derivatize the oxazolidinone-fused THIQs (Scheme 1). We were pleased to nd that the oxazolidinone functional group could be efficiently removed with Ba(OH) 2 $8H 2 O to afford THIQ 2a in 81% yield. 16,17 Alternatively, reduction with DIBAL afforded Nmethyl THIQ 6a in 73% yield, providing a facile access of our hydrogenated products to N-methyl protected THIQs.
To elucidate the factors controlling the trans-selectivity in this transformation, several control experiments were Table 2 Substrate scope of the trans-selective hydrogenation of 1,3-disubstituted isoquinolines a a Isolated yields on a 0.2 mmol scale. SFC analysis was used to determine ee. b Determined by 1 H NMR analysis of crude reaction. c Performed at 60 bar H 2 and 60 C. d Total isolated yield of inseparable diastereomers. conducted to probe the reaction mechanism (Scheme 2). Substituting TBABr for TBAI as the additive gave a 1 : 1.2 dr favoring the cis-product, with high enantioselectivities exhibited for both products (Scheme 2A). This suggests that the bromide ligand facilitates p-facial exchange of the substrate over iodide to afford higher levels of the trans-diastereomer. 18,19 Replacing 1,2-DCE solvent for THF also delivered similar results, indicating that ethereal solvents inhibit the formation of trans-2a through stronger coordination with iridium (Scheme 2B). 20 Overall, the combination of non-coordinating, chlorinated solvents and smaller halides are crucial in governing the observed trans-selectivity.
Deuterium experiments were also conducted to determine the degree of deuteration of our hydrogenated products (Scheme 3). Interestingly, the combination of both D 2 and CD 3 COOD delivered deuterium at the C1-, C3-, and C4-positions of the THIQ, as well as at the methylene carbon of the hydroxymethyl functional group (Scheme 3A). We attribute this exocyclic deuteration to a competitive b-hydride elimination pathway that is operative in situ under our trans-hydrogenation conditions (Scheme 3B). 21,22 However, this is likely not a critical pathway toward the trans-product, as deuterium incorporation in the corresponding cis-isomer (cis-2a) is also observed. Exchanging either D 2 or CD 3 COOD for their protic counterparts demonstrated deuteride delivery primarily from the gas at the C1-and C3-positions of 2a, yet the acid also enables reduction of the isoquinoline ring. This suggests a proton-hydride exchange occurring between the acid and the iridium hydride species for hydrogenation. 19,23 Further investigations of the mechanism 24 and other applications of this technology are currently underway and will be reported in due course.

Conclusions
In conclusion, we have developed an asymmetric trans-selective hydrogenation reaction of 1,3-disubstituted isoquinolines for the syntheses of enantioenriched trans-THIQs. Key to this enantio-and diastereoselective reaction is the hydroxymethyl directing group at the C1-position which enables p-facial exchange of the substrate and facilitates hydride delivery from the sterically more hindered face. This method tolerates a wide range of electronics, Lewis basic functionalities, and substitution at the C1, C3, and C8-positions of the isoquinoline core, representing one of the rst examples of an asymmetric hydrogenation technology to selectively access the trans-diastereomer of hydrogenated aromatic compounds.

Data availability
Data for this work, including optimization tables, general experimental procedures, characterization data for all new compounds and X-ray data are provided in the ESI. †

Conflicts of interest
There are no conicts to declare.