There are a number of nice hotels in NYC, but considering service, room quality and location, the Marriot Marquis in Times Square is my consistent choice.
Located right in the middle of Times Square (as seen on New Years Eve), it is in a concentrated area with access to subway lines, shopping, restaurants and theater. I took advantage of all of them. My wife took advantage of Tiffany's which is half a dozen blocks away...an easy walk by the diamond district. And, there is always so much energy in Times Square. It's fun to get a Starbucks, grab a table in the square and people watch.
I use the subways when I can and the station 42nd St ( a few blocks from the hotel) can take you almost anywhere in Manhattan.
Broadway shows abound within a few blocks of the hotel. We saw several shows, which were only a few minutes walk away. Also, a number of fine quality restaurants are nearby including restaurant row on 46th St. between 8th and 9th Ave.
The Broadway Lounge overlooking Times Square (8th floor) is a treat. It's a great experience to cap off an evening of theater and dinner with a drink in this lounge.
The concierge service, in the concierge lounge is great. Joe took good care of us, helping us out with obtaining boarding passes for our flight back to California, along with getting us a town car for the ride to JFK.
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