The Carlton is a classic old school hotel - grand lobby, beautiful furnishing and TINY rooms. The photos posted on the web of the "standard room" which showed an armchair, bed and desk were nothing like the room we had, which had a bed, a small desk and desk chair and about 1 square foot of space. No where to put a suitcase (it did have drawers and a small closet, but this meant unpacking for our short stay). Nowhere other than the bed to sit. I know that New York hotel rooms are small . The bathroom was beautiful and had a bath and a shower, but again, did not even have a shelf or any other space to put your toothbrush & toiletries. We also had an extremely loud heater/air con that kept me awake much of the night.
The area appears very safe. To me, having stayed downtown in the past, it was dull and lacked places to eat nearby. That said, the concierge was very helpful at making reservations or suggeting places to eat. It is close to the some of the shopping areas and the empire state. It's about as far away from a subway station as you can get in Manhatten (which is still not that far)
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