Donatello is a first class hotel/ timeshare facility 1 block from Union Square, the heart of downtown San francisco tourist area, but a block in the other direction from the Tenderloin District the heart of the homeless/prostitute/drug addict district. Both areas have their own personality. Hotel itself is very well maintained and rooftop lounge terrace is an added bonus. Staff is very willing to help and there are what seem like an unlimited number of good restaurant choices within walking distance. Try the cornflake covered french toast for breakfast at Max's in the square at Maison and Geary or if your budget is lower Jack in the Box across the street has 2 eggs, bacon, home fries and toast for $2.99.
For best overview of San Francisco try drinks(or breakfast, lunch or dinner) at the 36th floor Grandview Lounge at the Hyatt.
The best way to travel San Francisco is public transportation muni. It is about 45 minutes from one end to the other and covers all major tourist attractions. An unlimited 7 day pass is $27. It includes the cable car which is fun attraction once but not a regular mode of transportation as lineups are 30-40 minutes most of the day.
One final hint, book a limo to and from airport rather than a taxi. It is about $5 cheaper and a lot more comfortable.
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