Stayed here a few nights recently while doing both work and some touring. The location is very good as is the location of the Marriott across the street or the Hyatt right down the block. I took the Bart from the airport to Powel Street and then rode the cable car (get the right one) to the hotel from there. The hotel is less than a block from the start of the cable car line. Kind of a cool way to commute and sightsee at the same time. If you have a car prepare to pay some big change to park in the underground garage.
The hotel was okay, at best. I stay in Hilton Hotels around the world and this is not one of the nice ones. I do draw the line at the mold and mildew crawling up the shower curtain - they did replace this immediately when I called the front desk. Not so easy to fix on the tile, though. Good points were the location, fairly large room size, and quiet. Bed and pillows were good for me although the Hilton radio gadget they advertise sounds tinny and has only a pushbutton volume control - I'll bet the Hilton execs don't use this baby at home. Hotel personnel were okay with the front desk people being very short at times. I can't recommend the windowless restaurant in the hotel as the food was barely warm even though the selection was not bad. Okay, so I'll try the Marriott or the Hyatt next time if I'm looking for a brand name around here.
By the way, if you are going to rent bikes I'd really recommend the Bay City rental place over Blazing Saddles. My bike from Blazing was a junker compared to the Bay City bikes I examined while touring.
hotel reviews