Do not get me wrong, Mark Twain is a nice place. And that's about it. Claiming it is "boutique" or "stylish" is clearly misleading.
As I stayed in this hotel during the WWDC11, when five-thousand-something crowd of Apple developers invade San Francisco, it is hard to fault the hotel for its pricing scheme, simply driven by the supply and demand. Even at such time, the rates were favorable for received service. The rooms were clean and comfortable, albeit dated and slightly tacky. The bathrooms were well kept. The hotel Wi-Fi was somewhat wonky, but that was quickly remedied by developers setting their own access points throughout hotel using the hotel's fast and functional Ethernet. The only major issue was the fact, that we were forced to change rooms during the last night due to the piping malfunction, fortunately with a decent remedy offer from the the hotel. Also, if easily spooked, be sure to not walk through Panhandle to get to the Market - it is easier and safer to go along O'Farrell and Powell.
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