main-multisession-sub-005_ses-03_union_mask.py

#!/usr/bin/env python
# coding: utf-8

# # Import packages & functions

# In[1]:


print("importing modules")
import os
import sys
import json
import argparse
import numpy as np
import time
import random
import string
import h5py
from tqdm import tqdm
import webdataset as wds
from PIL import Image
import pandas as pd
import nibabel as nib
import nilearn

import matplotlib.pyplot as plt
import torch
import torch.nn as nn
from torchvision import transforms

# tf32 data type is faster than standard float32
torch.backends.cuda.matmul.allow_tf32 = True

import utils
from utils import load_preprocess_betas, resample, applyxfm, apply_thresh, resample_betas

# imports utils from mindeye_preproc as "preproc"
import importlib.util
parent_utils_path = "/home/ri4541/mindeye_preproc/analysis/utils.py"
spec = importlib.util.spec_from_file_location("utils", parent_utils_path)
preproc = importlib.util.module_from_spec(spec)
parent_dir = os.path.dirname(parent_utils_path)
if parent_dir not in sys.path:
    sys.path.append(parent_dir)
spec.loader.exec_module(preproc)

if utils.is_interactive():
    from IPython.display import clear_output # function to clear print outputs in cell
    get_ipython().run_line_magic('load_ext', 'autoreload')
    # this allows you to change functions in models.py or utils.py and have this notebook automatically update with your revisions
    get_ipython().run_line_magic('autoreload', '2')
    
seed = utils.get_slurm_seed()


# # Princeton data prep

# ## Load Data & Design

# In[2]:


if utils.is_interactive():
    sub = "sub-005"
    session = "ses-03"
    task = 'C'  # 'study' or 'A'; used to search for functional run in bids format
    func_task_name = 'C'
else:
    sub = os.environ["sub"]
    session = os.environ["session"]
    task = os.environ["task"]
    func_task_name = 'C'

if session == "all":
    ses_list = ["ses-01", "ses-02"]  # list of actual session IDs
    design_ses_list = ["ses-01", "ses-02"]  # list of session IDs to search for design matrix
else:
    ses_list = [session]
    design_ses_list = [session]
    
task_name = f"_task-{task}" if task != 'study' else ''
resample_voxel_size = False
resample_post_glmsingle = False  # do you want to do voxel resampling here? if resample_voxel_size = True and resample_post_glmsingle = False, assume the resampling has been done prior to GLMsingle, so just use resampled directory but otherwise proceed as normal
load_from_resampled_file = False  # do you want to load resampled data from file? if True, assume resampling was done in this notebook before, and that we're not using the GLMsingle resampled data
    
train_test_split = 'MST' # 'MST', 'orig', 'unique'
remove_close_to_MST = False
remove_random_n = False

if remove_close_to_MST or remove_random_n:
    assert remove_close_to_MST != remove_random_n  # don't remove both sets of images

n_to_remove = 0
if remove_random_n:
    assert train_test_split == 'MST'  # MST images are excluded from the n images removed, so only makes sense if they're not in the training set
    n_to_remove = 150
    
if resample_voxel_size:
    # voxel size was unchanged in glmsingle, want to perform resampling here
    resampled_vox_size = 2.5
    resample_method = "sinc"  # {trilinear,nearestneighbour,sinc,spline}, credit: https://johnmuschelli.com/fslr/reference/flirt.help.html
    
    # file name helper variables
    vox_dim_str = str(resampled_vox_size).replace('.', '_')  # in case the voxel size has a decimal, replace with an underscore
    resampled_suffix = f"resampled_{vox_dim_str}mm_{resample_method}"
    mask_resampled_suffix = resampled_suffix
    if resample_post_glmsingle:
        resampled_suffix += '_postglmsingle'
    else:
        resampled_suffix += '_preglmsingle'


# In[3]:


session_label = preproc.get_session_label(ses_list)
print('session label:', session_label)
n_runs, _ = preproc.get_runs_per_session(sub, session, ses_list)


# In[4]:


if utils.is_interactive():
    glmsingle_path = f"/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2/glmsingle_{sub}_{session_label}_task-{task}"
else:
    glmsingle_path = os.environ["glmsingle_path"]
    
designdir = "/home/ri4541/real_time_mindEye2"
print(glmsingle_path)

if resample_voxel_size:
    # option 1: we are using original (non-resampled) GLMsingle outputs and doing the resampling here
    # option 2: doing resampling pre-GLMsingle and using those outputs; no resampling involved here
    if resample_post_glmsingle:
        # option 1
        orig_glmsingle_path = glmsingle_path
        glmsingle_path += f"_{resampled_suffix}"
        print("resampled glmsingle path:", glmsingle_path)
        if load_from_resampled_file:
            # resampling is already done; load from file
             assert os.path.exists(glmsingle_path)  # the new directory must have been created if we reached here
        else:
            # don't load from file; do resampling here
            os.makedirs(glmsingle_path,exist_ok=True)
    else:
        # option 2
        glmsingle_path += f"_{resampled_suffix}"
        print("glmsingle path:", glmsingle_path)

assert os.path.exists(glmsingle_path)
print("glmsingle path exists!")


# In[5]:


data, starts, images, is_new_run, image_names, unique_images, len_unique_images = preproc.load_design_files(
    sub=sub,
    session=session,
    func_task_name=task,
    designdir=designdir,
    design_ses_list=design_ses_list
)

if sub == 'sub-001':
    if session == 'ses-01':
        assert image_names[0] == 'images/image_686_seed_1.png'
    elif session in ('ses-02', 'all'):
        assert image_names[0] == 'all_stimuli/special515/special_40840.jpg'
    elif session == 'ses-03':
        assert image_names[0] == 'all_stimuli/special515/special_69839.jpg'
    elif session == 'ses-04':
        assert image_names[0] == 'all_stimuli/rtmindeye_stimuli/image_686_seed_1.png'
elif sub == 'sub-003':
    assert image_names[0] == 'all_stimuli/rtmindeye_stimuli/image_686_seed_1.png'

unique_images = np.unique(image_names.astype(str))
unique_images = unique_images[(unique_images!="nan")]
len_unique_images = len(unique_images)
print("n_runs",n_runs)

if (sub == 'sub-001' and session == 'ses-04') or (sub == 'sub-003' and session == 'ses-01'):
    assert len(unique_images) == 851

print(image_names[:4])
print(starts[:4])
print(is_new_run[:4])

if remove_random_n:
    # want to remove 150 imgs
    # 100 special515 imgs are repeated 3x (300 total)
    # all other train imgs are only shown once (558 total)
    # of the 150, want to sample proportionally since we're cutting all repeats for special515
    # so take out 51 (17 unique) from special515 and 99 from rest = removing 150 total
    np.random.seed(seed)
    options_to_remove = [x for x in set(image_names) if str(x) != 'nan' and x != 'blank.jpg' and 'MST_pairs' not in x and 'special515' not in x and list(image_names).count(x)==1]  # all the imgs that only appear once (this is O(N^2) b/c of count() within list comprehension but image_names is a relatively small list)
    options_to_remove_special515 = [x for x in set(image_names) if str(x) != 'nan' and x != 'blank.jpg' and 'MST_pairs' not in x and 'special515' in x and list(image_names).count(x)>1]  # all the special515 images that are repeated (count()>1 necessary because there are special515 that are not repeated)
    imgs_to_remove = np.random.choice(options_to_remove, size=99, replace=False)
    imgs_to_remove = np.append(imgs_to_remove, np.random.choice(options_to_remove_special515, size=17, replace=False))

image_idx = np.array([])  # contains the unique index of each presented image
vox_image_names = np.array([])  # contains the names of the images corresponding to image_idx
all_MST_images = dict()
for i, im in enumerate(image_names):
    # skip if blank, nan
    if im == "blank.jpg":
        i+=1
        continue
    if str(im) == "nan":
        i+=1
        continue
    vox_image_names = np.append(vox_image_names, im)
    if remove_close_to_MST:  # optionally skip close_to_MST images 
        if "closest_pairs" in im:
            i+=1
            continue
    elif remove_random_n:
        if im in imgs_to_remove:
            i+=1
            continue
            
    image_idx_ = np.where(im==unique_images)[0].item()
    image_idx = np.append(image_idx, image_idx_)
    
    if (sub == 'sub-001' and session == 'ses-04') or (sub == 'sub-003' and session == 'ses-01'):  # MST images are ones that matched these image titles
        import re
        if ('w_' in im or 'paired_image_' in im or re.match(r'all_stimuli/rtmindeye_stimuli/\d{1,2}_\d{1,3}\.png$', im) or re.match(r'images/\d{1,2}_\d{1,3}\.png$', im)):  
        # the regexp here looks for **_***.png, allows 1-2 chars before underscore and 1-3 chars after it
            # print(im)
            all_MST_images[i] = im
            i+=1            
    elif 'MST' in im:
        all_MST_images[i] = im
        i+=1
    
image_idx = torch.Tensor(image_idx).long()
# for im in new_image_names[MST_images]:
#     assert 'MST_pairs' in im
# assert len(all_MST_images) == 300

unique_MST_images = np.unique(list(all_MST_images.values())) 

MST_ID = np.array([], dtype=int)
if remove_close_to_MST:
    close_to_MST_idx = np.array([], dtype=int)
if remove_random_n:
    random_n_idx = np.array([], dtype=int)

vox_idx = np.array([], dtype=int)
j=0  # this is a counter keeping track of the remove_random_n used later to index vox based on the removed images; unused otherwise
for i, im in enumerate(image_names):  # need unique_MST_images to be defined, so repeating the same loop structure
    # skip if blank, nan
    if im == "blank.jpg":
        i+=1
        continue
    if str(im) == "nan":
        i+=1
        continue
    if remove_close_to_MST:  # optionally skip close_to_MST images 
        if "closest_pairs" in im:
            close_to_MST_idx = np.append(close_to_MST_idx, i)
            i+=1
            continue
    if remove_random_n:
        if im in imgs_to_remove:
            vox_idx = np.append(vox_idx, j)
            i+=1
            j+=1
            continue
    j+=1
    curr = np.where(im == unique_MST_images)
    # print(curr)
    if curr[0].size == 0:
        MST_ID = np.append(MST_ID, np.array(len(unique_MST_images)))  # add a value that should be out of range based on the for loop, will index it out later
    else:
        MST_ID = np.append(MST_ID, curr)
        
assert len(MST_ID) == len(image_idx)
# assert len(np.argwhere(pd.isna(data['current_image']))) + len(np.argwhere(data['current_image'] == 'blank.jpg')) + len(image_idx) == len(data)
# MST_ID = torch.tensor(MST_ID[MST_ID != len(unique_MST_images)], dtype=torch.uint8)  # torch.tensor (lowercase) allows dtype kwarg, Tensor (uppercase) is an alias for torch.FloatTensor
print(MST_ID.shape)
if (sub == 'sub-001' and session == 'ses-04') or (sub == 'sub-003' and session == 'ses-01'):
    assert len(all_MST_images) == 100


# ## Load images

# In[6]:


import imageio.v2 as imageio
resize_transform = transforms.Resize((224, 224))
MST_images = []
images = None
for im_name in tqdm(image_idx):
    if sub == 'sub-001' and session == 'ses-01':
        image_file = f"all_stimuli/rtmindeye_stimuli/{unique_images[im_name]}"
    else:
        image_file = f"{unique_images[im_name]}"
    im = imageio.imread(image_file)
    im = torch.Tensor(im / 255).permute(2,0,1)
    im = resize_transform(im.unsqueeze(0))
    if images is None:
        images = im
    else:
        images = torch.vstack((images, im))
    if (sub == 'sub-001' and session == 'ses-04') or (sub == 'sub-003' and session == 'ses-01'):
        if ('w_' in image_file or 'paired_image_' in image_file or re.match(r'all_stimuli/rtmindeye_stimuli/\d{1,2}_\d{1,3}\.png$', image_file) or re.match(r'all_stimuli/rtmindeye_stimuli/images/\d{1,2}_\d{1,3}\.png$', image_file)):  
            MST_images.append(True)
        else:
            MST_images.append(False)
    else:   
        if ("MST_pairs" in image_file): # ("_seed_" not in unique_images[im_name]) and (unique_images[im_name] != "blank.jpg") 
            MST_images.append(True)
        else:
            MST_images.append(False)

print("images", images.shape)
MST_images = np.array(MST_images)
print("MST_images", len(MST_images))
if (sub == 'sub-001' and session == 'ses-04') or (sub == 'sub-003' and session == 'ses-01'):
    assert len(MST_images[MST_images==True]) == 100
print("MST_images==True", len(MST_images[MST_images==True]))


# In[7]:


# want IDs of pairmates based on MST_images
# create "MST_pairmates" which is a 25x2 array with indices of the 25 pairs based on MST_images == True

assert unique_MST_images.shape[0] % 2 == 0  # make sure it's divisible by 2
MST_pairmate_names = unique_MST_images.reshape(int(unique_MST_images.shape[0]/2),2)
# print(MST_pairmate_names)

MST_pairmate_indices = np.empty(shape=MST_pairmate_names.shape, dtype=int)
for p, pair in enumerate(MST_pairmate_names):
    for i, im in enumerate(pair):
        MST_pairmate_indices[p][i] = np.where(np.isin(list(all_MST_images.values()), im))[0][0]  # just take the first repeated instance of an image
        
print(MST_pairmate_indices.shape, MST_pairmate_indices)


# In[8]:


if (sub == 'sub-001' and session in ('ses-02', 'ses-03', 'all')):
    # MST_pairs contains the indices of repeats based on all_MST_images
    # all_MST_images contains the indices of images from image_names
    MST_pairs = utils.find_paired_indices(torch.tensor(MST_ID))
    MST_pairs = np.array(sorted(MST_pairs[:-1], key=lambda x: x[0]))  # we added a fake value as a placeholder so index out the last group of pairs

    # assert images[MST_pairs]

    fig, ax = plt.subplots(1, 3, figsize=(10,4))
    fig.suptitle('Sample MST pairs')

    ax[0].imshow(images[MST_pairs[-1][0]].permute(1,2,0).numpy())
    ax[0].set_title(f"Trial 0")

    ax[1].imshow(images[MST_pairs[-1][1]].permute(1,2,0).numpy())
    ax[1].set_title(f"Trial 1")

    ax[2].imshow(images[MST_pairs[-1][2]].permute(1,2,0).numpy())
    ax[2].set_title(f"Trial 2")

    plt.setp(ax, xticks=[], yticks=[])
    plt.tight_layout()
    plt.show()


# In[9]:


# pairs has the indices of all repeated images
pairs = utils.find_paired_indices(image_idx)
pairs = sorted(pairs, key=lambda x: x[0])

fig, axes = plt.subplots(1, 3, figsize=(6, 2))  # 1 row, 3 columns
for i, ax in enumerate(axes):
    ax.imshow(images[i].permute(1, 2, 0).numpy())
    ax.set_title(f"Trial {i}")
    ax.axis("off")  # Hide axes for better visualization

plt.tight_layout()
# output_path = os.path.join(output_dir, "trials_plot.png")
# plt.savefig(output_path, dpi=300)  # Save figure
plt.show()


# In[10]:


p=0

# plot 2 repeats (anything in pairs should have 2 repeats, even if there's more)
fig, ax = plt.subplots(1, 2, figsize=(10,8))

ax[0].imshow(images[pairs[p][0]].permute(1,2,0).numpy())
ax[0].set_title(f"Repeat 1")

ax[1].imshow(images[pairs[p][1]].permute(1,2,0).numpy())
ax[1].set_title(f"Repeat 2")

plt.setp(ax, xticks=[], yticks=[])
plt.tight_layout()
plt.show()


# In[11]:


def get_image_pairs(sub, session, func_task_name, designdir):
    """Loads design files and processes image pairs for a given session."""
    _, _, _, _, image_names, unique_images, _ = preproc.load_design_files(
        sub=sub,
        session=session,
        func_task_name=func_task_name,
        designdir=designdir,
        design_ses_list=[session]  # Ensure it's a list
    )
    return utils.process_images(image_names, unique_images)


# In[12]:


from collections import defaultdict

all_dicts = []
for s_idx, s in enumerate(ses_list):
    im, vo, _ = get_image_pairs(sub, s, func_task_name, designdir)
    assert len(im) == len(vo)
    all_dicts.append({k:v for k,v in enumerate(vo)})

# for the train set (ses-01-02 non-MST)
image_to_indices = defaultdict(lambda: [[] for _ in range(len(ses_list))])
for ses_idx, idx_to_name in enumerate(all_dicts):
    for idx, name in idx_to_name.items():
        image_to_indices[name][ses_idx].append(idx)
        
image_to_indices = dict(image_to_indices)

# for the test set (ses-03)
# test_image_to_indices = defaultdict(lambda: [[] for _ in range(len([ses_list[-1]]))])
# for ses_idx, idx_to_name in enumerate([all_dicts[-1]]):
#     for idx, name in idx_to_name.items():
#         test_image_to_indices[name][ses_idx].append(idx)
        
# test_image_to_indices = dict(test_image_to_indices)


# In[13]:


# train_pairs_list = []
# test_pairs_list = []

if sub == 'sub-005' and ses_list == ["ses-01", "ses-02"]:
    for image, (ses0_indices, ses1_indices) in image_to_indices.items():
        # Offset session 1 indices by 693
        image_to_indices[image] = [ses0_indices, [i + 693 for i in ses1_indices]]

#         # Combine all repeat indices (across both sessions)
#         all_indices = ses0_indices + ses1_indices_offset

#         # Only include if there are at least 2 repeats
#         if len(all_indices) >= 2:
#             train_pairs_list.append(all_indices)
        
#     for i in test_image_to_indices.values():
#         # print(i[0])
#         # Only include if there are at least 2 repeats
#         if len(i[0]) >= 2:
#             test_pairs_list.append(i[0])
            
#     train_test_pairs = [train_pairs_list, test_pairs_list]
            
# elif sub == 'sub-005' and ses_list == ["ses-01", "ses-03"]:
#     pairs_list = []

#     if len(ses_list) > 2:
#         # Case 1: Aggregate results from multiple sessions (ses_list[:-1]), concatenating into a single list
#         combined_pairs = sum([get_image_pairs(sub, s, func_task_name, designdir) for s in ses_list[:-1]], [])
#         pairs_list.append(combined_pairs)

#         # Case 2: Process last session separately
#         pairs_list.append(get_image_pairs(sub, ses_list[-1], func_task_name, designdir))

#     else:
#         # Case 3: Process both sessions individually if ses_list has only 2 entries
#         pairs_list.extend([get_image_pairs(sub, s, func_task_name, designdir) for s in ses_list])

#     assert len(pairs_list) == 2


# In[14]:


if resample_voxel_size:
    from nilearn.masking import apply_mask, unmask
    ref_name = f'{glmsingle_path}/boldref_resampled.nii.gz'
    omat_name = f'{glmsingle_path}/boldref_omat'


# In[15]:


from nilearn.plotting import plot_roi, plot_anat, plot_epi

mask_name = f'{glmsingle_path}/{sub}_{session_label}{task_name}_brain'
if resample_voxel_size:
    if resample_post_glmsingle is True:
        # use original mask directory
        mask_in_name = f'{orig_glmsingle_path}/{sub}_{session}{task_name}_brain.nii.gz'
        mask_out_name = mask_name + f"_{mask_resampled_suffix}.nii.gz"
        assert os.path.exists(mask_in_name)
        applyxfm(mask_in_name, ref_name, omat_name, resample_method, output=mask_out_name)
        apply_thresh(mask_out_name, 0.5, output=mask_out_name)  # binarize the mask since resampling can result in non- 0 or 1 values
    mask_name += f"_{mask_resampled_suffix}"

mask_name += ".nii.gz"
print(mask_name)
avg_mask = nib.load(mask_name)
# mask info
dimsize=avg_mask.header.get_zooms()
affine_mat = avg_mask.affine
brain=avg_mask.get_fdata()
xyz=brain.shape #xyz dimensionality of brain mask and epi data

print('Mask dimensions:', dimsize)
print('')
print('Affine:')
print(affine_mat)
print('')
print(f'There are {int(np.sum(brain))} voxels in the included brain mask\n')


# In[16]:


from nilearn.plotting import plot_roi
assert sub == 'sub-005' and session == "ses-03"
print('loading brain mask')
# func_masks, avg_mask, nsd_masks, roi = utils.get_mask(['ses-01', 'ses-02', 'ses-03'], sub, func_task_name)
avg_mask = nib.load('/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2/glmsingle_sub-005_task-C/sub-005_final_brain.nii.gz')
final_mask = nib.load('/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2/glmsingle_sub-005_task-C/sub-005_final_mask.nii.gz')

# mask info
dimsize=avg_mask.header.get_zooms()
affine_mat = avg_mask.affine
brain=avg_mask.get_fdata()
xyz=brain.shape #xyz dimensionality of brain mask and epi data

print('Mask dimensions:', dimsize)
print('')
print('Affine:')
print(affine_mat)
print('')
print(f'There are {int(np.sum(brain))} voxels in the included brain mask\n')

plot_roi(final_mask, bg_img=avg_mask)
plt.show()


# In[17]:


union_mask = np.load('/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2/glmsingle_sub-005_task-C/union_mask_from_ses-01-02.npy')


# ## Load GLMSingle voxel data

# In[18]:


vox = None
needs_postprocessing = False
params = (session, ses_list, remove_close_to_MST, image_names, remove_random_n, vox_idx)

if resample_post_glmsingle == True:
    glm_save_path_resampled = f"{glmsingle_path}/vox_resampled.nii.gz"
    if load_from_resampled_file == True:
        # resampling was done in this notebook so we can load from file
        vox = nib.load(glm_save_path_resampled)
    else:
        # do resampling here
        assert os.path.exists(ref_name) and os.path.exists(omat_name), "need to generate the boldref and omat separately since we don't have access to the functional data here; either do so using flirt on the command line or copy over the glmsingle resampled outputs"
        vox = load_preprocess_betas(orig_glmsingle_path, *params)
        vox = resample_betas(orig_glmsingle_path, sub, session, task_name, vox, glmsingle_path, glm_save_path_resampled, ref_name, omat_name)
    needs_postprocessing = True

if vox is None:
    # either resampling was done in glmsingle or we aren't resampling 
    vox = load_preprocess_betas(glmsingle_path, *params)

if needs_postprocessing == True:
    vox = apply_mask(vox, avg_mask)
    vox = vox.reshape(-1, vox.shape[-1])  # flatten the 3D image into np array with shape (voxels, images)
    print(vox.shape)

assert len(vox) == len(image_idx)


# In[19]:


ses_mask = nib.load(f'/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2/glmsingle_sub-005_{session_label}_task-C/sub-005_{session_label}_task-C_brain.nii.gz')
assert np.all(ses_mask.affine == final_mask.affine)
assert np.all(ses_mask.shape == final_mask.shape)


# In[20]:


# get vox into the same shape as the union mask
v = nilearn.masking.unmask(vox, ses_mask)  # move back to 3D based on own session mask
# final_mask = nilearn.masking.intersect_masks([avg_mask, roi])
vox = nilearn.masking.apply_mask(v, final_mask)  # re-flatten based on final mask so everything is in the same shape now
print(vox.shape)
vox = vox[:, union_mask]
print("applied union roi mask")
print(vox.shape)


# ## Reliability calculation

# ### Calculate reliability (corr between first and second presentation of same image) for every voxel

# In[21]:


pairs_homog = np.array([[p[0], p[1]] for p in pairs])


# In[22]:


same_corrs = []
diff_corrs = []
for isamp, samp in enumerate(vox[pairs_homog]):
    avg_same_img = []
    for i in range(samp.shape[0]):
        for j in range(i, samp.shape[0]):
            if i != j:
                avg_same_img.append(np.array([np.corrcoef(samp[i, :], samp[j, :])[0,1]]))
    
    same_corrs.append(np.mean(avg_same_img))
                       
    avg_diff_img = []
    for isamp_j, samp_j in enumerate(vox[pairs_homog]):
        if isamp_j != isamp:
            for i in range(samp_j.shape[0]):
                for j in range(i, samp_j.shape[0]):
                    if i != j:
                        avg_diff_img.append(np.array([np.corrcoef(samp[i, :], samp_j[j, :])[0,1]]))
                                    
    # print(len(avg_diff_img))
    diff_corrs.append(np.mean(avg_diff_img))


print(len(same_corrs), len(diff_corrs))
same_corrs = np.array(same_corrs)
diff_corrs = np.array(diff_corrs)


plt.figure(figsize=(5,4))
plt.title(f"{sub}_{session} same/diff Pearson corr.")
plt.plot(np.sort(same_corrs),c='blue',label='same')
plt.plot(np.sort(diff_corrs),c='cyan',label='diff')
plt.axhline(0,c='k',ls='--')
plt.legend()
plt.xlabel("sample")
plt.ylabel("Pearson R")
plt.show()


# In[23]:


vox_pairs = utils.zscore(vox[pairs_homog])
plt.figure(figsize=(5,4))
plt.title(f"{sub}_{session} same minus diff difference Pearson corr.")
plt.plot(np.sort(same_corrs) - np.sort(diff_corrs),c='cyan',label='difference')
plt.axhline(0,c='k',ls='--')
plt.legend()
plt.xlabel("sample")
plt.ylabel("Pearson R")
plt.show()


# # Training MindEye

# In[24]:


utils.seed_everything(seed)

if train_test_split == 'orig':
    # train = all images except images that were repeated
    # test = average of the same-image presentations
    imageTrain = np.arange(len(images))
    train_image_indices = np.array([item for item in imageTrain if item not in pairs.flatten()])
    test_image_indices = pairs
    print(len(train_image_indices), len(test_image_indices))
    assert len(train_image_indices) + len(test_image_indices) == len(image_idx)
elif train_test_split == 'MST':
    # non-MST images are the train split
    # MST images are the test split
    MST_idx = np.array([v for k,v in image_to_indices.items() if 'MST_pairs' in k])
    non_MST_idx = [v for k,v in image_to_indices.items() if 'MST_pairs' not in k]
    non_MST_idx = np.array([z for y in non_MST_idx for x in y for z in x])  # flatten the indices
    train_image_indices = non_MST_idx
    test_image_indices = MST_idx.flatten()  # MST_idx contains the mapping for the different test sets; test_image_indices has all MST indices combined
    print(len(train_image_indices), len(test_image_indices))
    assert len(train_image_indices) + len(test_image_indices) == len(vox)
elif train_test_split == 'unique':
    imageTest = np.arange(len(images))
    train_image_indices = pairs.flatten()
    test_image_indices = np.array([item for item in imageTest if item not in pairs.flatten()])
    print(len(train_image_indices), len(test_image_indices))
    assert len(train_image_indices) + len(test_image_indices) == len(image_idx)
else:
    raise Exception("invalid train_test_split")

# TODO add assertion that verifies file names in train and test don't overlap, guards against repeats

for i in train_image_indices:
    assert i not in test_image_indices


# In[25]:


train_mean = np.mean(vox[train_image_indices],axis=0)
train_std = np.std(vox[train_image_indices],axis=0)

vox = utils.zscore(vox,train_mean=train_mean,train_std=train_std)
print("voxels have been zscored")
print(vox[:,0].mean(), vox[:,0].std())
print("vox", vox.shape)


# In[26]:


# for idx in deleted_indices:
#     # check image names to be deleted match
#     original_name = vox_image_dict[idx]
#     matching_indices = [i for i in deleted_indices if vox_image_dict[i] == original_name]
#     assert all(vox_image_dict[i] == original_name for i in matching_indices), \
#         f"Mismatch in image names for deleted indices {matching_indices}"

#     # check image data to be deleted match
#     base_image = images[matching_indices[0]]  # Reference image
#     for i in matching_indices[1:]:
#         assert np.array_equal(base_image, images[i]), \
#             f"Mismatch in image data for {vox_image_dict[i]} at index {i}"

# images = images[kept_indices]


# In[27]:


images = torch.Tensor(images)
vox = torch.Tensor(vox)
assert len(images) == len(vox)


# In[28]:


### Multi-GPU config ###
from accelerate import Accelerator, DeepSpeedPlugin

local_rank = os.getenv('RANK')
if local_rank is None: 
    local_rank = 0
else:
    local_rank = int(local_rank)
print("LOCAL RANK ", local_rank)  

data_type = torch.float32 # change depending on your mixed_precision

accelerator = Accelerator(split_batches=False)
batch_size = 8 


# In[29]:


print("PID of this process =",os.getpid())
device = accelerator.device
print("device:",device)
world_size = accelerator.state.num_processes
distributed = not accelerator.state.distributed_type == 'NO'
num_devices = torch.cuda.device_count()
global_batch_size = batch_size * num_devices
print("global_batch_size", global_batch_size)
if num_devices==0 or not distributed: num_devices = 1
num_workers = num_devices
print(accelerator.state)

# set data_type to match your mixed precision (automatically set based on deepspeed config)
if accelerator.mixed_precision == "bf16":
    data_type = torch.bfloat16
elif accelerator.mixed_precision == "fp16":
    data_type = torch.float16
else:
    data_type = torch.float32

print("distributed =",distributed, "num_devices =", num_devices, "local rank =", local_rank, "world size =", world_size, "data_type =", data_type)
print = accelerator.print # only print if local_rank=0


# ## Configurations

# In[30]:


# if running this interactively, can specify jupyter_args here for argparser to use
if utils.is_interactive():
    model_name = 'testing_MST' # 'sub-001_multi_bs24_MST_rishab_MSTsplit_remove_150_random_seed_0'
    print("model_name:", model_name)
    
    # global_batch_size and batch_size should already be defined in the above cells
    # other variables can be specified in the following string:
    # jupyter_args = f"--data_path=/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2 --model_name={model_name}"

    jupyter_args = f"--data_path=/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2 \
                    --model_name={model_name} \
                    --no-multi_subject --subj=1 --batch_size={batch_size} \
                    --hidden_dim=1024 --clip_scale=1. \
                    --no-blurry_recon --blur_scale=.5 \
                    --no-use_prior --prior_scale=30 \
                    --n_blocks=4 --max_lr=3e-4 --mixup_pct=.33 --num_epochs=30 --no-use_image_aug \
                    --ckpt_interval=999 --no-ckpt_saving --new_test \
                    --multisubject_ckpt=/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2/train_logs/multisubject_subj01_1024hid_nolow_300ep"
    print(jupyter_args)
    jupyter_args = jupyter_args.split()


# In[31]:


parser = argparse.ArgumentParser(description="Model Training Configuration")
parser.add_argument(
    "--model_name", type=str, default="testing",
    help="name of model, used for ckpt saving and wandb logging (if enabled)",
)
parser.add_argument(
    "--data_path", type=str, default="/weka/proj-fmri/shared/natural-scenes-dataset",
    help="Path to where NSD data is stored / where to download it to",
)
parser.add_argument(
    "--subj",type=int, default=1, choices=[1,2,3,4,5,6,7,8],
    help="Validate on which subject?",
)
parser.add_argument(
    "--multisubject_ckpt", type=str, default=None,
    help="Path to pre-trained multisubject model to finetune a single subject from. multisubject must be False.",
)
parser.add_argument(
    "--num_sessions", type=int, default=0,
    help="Number of training sessions to include (if multi_subject, this variable doesnt matter)",
)
parser.add_argument(
    "--use_prior",action=argparse.BooleanOptionalAction,default=False,
    help="whether to train diffusion prior (True) or just rely on retrieval part of the pipeline (False)",
)
parser.add_argument(
    "--batch_size", type=int, default=32,
    help="Batch size can be increased by 10x if only training v2c and not diffusion diffuser",
)
parser.add_argument(
    "--wandb_log",action=argparse.BooleanOptionalAction,default=False,
    help="whether to log to wandb",
)
parser.add_argument(
    "--resume_from_ckpt",action=argparse.BooleanOptionalAction,default=False,
    help="if not using wandb and want to resume from a ckpt",
)
parser.add_argument(
    "--wandb_project",type=str,default="stability",
    help="wandb project name",
)
parser.add_argument(
    "--mixup_pct",type=float,default=.33,
    help="proportion of way through training when to switch from BiMixCo to SoftCLIP",
)
parser.add_argument(
    "--low_mem",action=argparse.BooleanOptionalAction,default=False,
    help="whether to preload images to cpu to speed things up but consume more memory",
)
parser.add_argument(
    "--blurry_recon",action=argparse.BooleanOptionalAction,default=True,
    help="whether to output blurry reconstructions",
)
parser.add_argument(
    "--blur_scale",type=float,default=.5,
    help="multiply loss from blurry recons by this number",
)
parser.add_argument(
    "--clip_scale",type=float,default=1.,
    help="multiply contrastive loss by this number",
)
parser.add_argument(
    "--prior_scale",type=float,default=30,
    help="multiply diffusion prior loss by this",
)
parser.add_argument(
    "--use_image_aug",action=argparse.BooleanOptionalAction,default=True,
    help="whether to use image augmentation",
)
parser.add_argument(
    "--num_epochs",type=int,default=120,
    help="number of epochs of training",
)
parser.add_argument(
    "--multi_subject",action=argparse.BooleanOptionalAction,default=False,
)
parser.add_argument(
    "--new_test",action=argparse.BooleanOptionalAction,default=True,
)
parser.add_argument(
    "--n_blocks",type=int,default=2,
)
parser.add_argument(
    "--hidden_dim",type=int,default=1024,
)
parser.add_argument(
    "--seq_past",type=int,default=0,
)
parser.add_argument(
    "--seq_future",type=int,default=0,
)
parser.add_argument(
    "--lr_scheduler_type",type=str,default='cycle',choices=['cycle','linear'],
)
parser.add_argument(
    "--ckpt_saving",action=argparse.BooleanOptionalAction,default=True,
)
parser.add_argument(
    "--ckpt_interval",type=int,default=5,
    help="save backup ckpt and reconstruct every x epochs",
)
parser.add_argument(
    "--seed",type=int,default=42,
)
parser.add_argument(
    "--max_lr",type=float,default=3e-4,
)

if utils.is_interactive():
    args = parser.parse_args(jupyter_args)
else:
    args = parser.parse_args()

# create global variables without the args prefix
for attribute_name in vars(args).keys():
    globals()[attribute_name] = getattr(args, attribute_name)
    
outdir = os.path.abspath(f'/scratch/gpfs/ri4541/MindEyeV2/src/mindeyev2/train_logs/{model_name}')
if not os.path.exists(outdir) and ckpt_saving:
    os.makedirs(outdir,exist_ok=True)
    
if use_image_aug or blurry_recon:
    import kornia
    import kornia.augmentation as K
    from kornia.augmentation.container import AugmentationSequential
if use_image_aug:
    img_augment = AugmentationSequential(
        kornia.augmentation.ColorJitter(brightness=0.4, contrast=0.4, saturation=0.4, hue=0.1, p=0.3),
        same_on_batch=False,
        data_keys=["input"],
    )
    # Define the blurring augmentations
    blur_augment = K.RandomGaussianBlur(kernel_size=(21, 21), sigma=(51.0, 51.0), p=1.)
    
if multi_subject:
    subj_list = np.arange(1,9)
    subj_list = subj_list[subj_list != subj]
else:
    subj_list = [subj]

print("subj_list", subj_list, "num_sessions", num_sessions)


# ## Prep data, models, and dataloaders

# In[32]:


if ckpt_saving:
    # save MST_ID for 2-alternative forced-choice retrieval evaluation 
    if 'MST' in model_name:
        eval_dir = os.environ["eval_dir"]
        print('saving MST info in', eval_dir)
        # Saving ##
        if not os.path.exists(eval_dir):
            os.mkdir(eval_dir)

        np.save(f"{eval_dir}/MST_ID.npy", MST_ID)
        np.save(f"{eval_dir}/MST_pairmate_indices.npy", MST_pairmate_indices)

    if remove_random_n:
        np.save(f"{eval_dir}/imgs_to_remove.npy", imgs_to_remove)

    np.save(f"{eval_dir}/train_image_indices.npy", train_image_indices)
    np.save(f"{eval_dir}/test_image_indices.npy", test_image_indices)
    np.save(f"{eval_dir}/images.npy", images)
    np.save(f"{eval_dir}/vox.npy", vox)


# ### Creating wds dataloader, preload betas and all 73k possible images

# In[33]:


def my_split_by_node(urls): return urls
num_voxels_list = []

if multi_subject:
    nsessions_allsubj=np.array([40, 40, 32, 30, 40, 32, 40, 30])
    num_samples_per_epoch = (750*40) // num_devices 
else:
    # num_samples_per_epoch = (750*num_sessions) // num_devices 
    num_samples_per_epoch = len(train_image_indices)

print("dividing batch size by subj_list, which will then be concatenated across subj during training...") 
batch_size = batch_size // len(subj_list)

num_iterations_per_epoch = num_samples_per_epoch // (batch_size*len(subj_list))

print("batch_size =", batch_size, "num_iterations_per_epoch =",num_iterations_per_epoch, "num_samples_per_epoch =",num_samples_per_epoch)


# In[34]:


train_data = {}
train_dl = {}

train_data[f'subj0{subj}'] = torch.utils.data.TensorDataset(torch.tensor(train_image_indices))
test_data = torch.utils.data.TensorDataset(torch.tensor(test_image_indices))


# In[35]:


num_voxels = {}
voxels = {}
for s in subj_list:
    print(f"Training with {num_sessions} sessions")
    train_dl = torch.utils.data.DataLoader(train_data[f'subj0{s}'], batch_size=batch_size, shuffle=True, drop_last=True, pin_memory=True)

    num_voxels_list.append(vox[0].shape[-1])
    num_voxels[f'subj0{s}'] = vox[0].shape[-1]
    voxels[f'subj0{s}'] = vox
    print(f"num_voxels for subj0{s}: {num_voxels[f'subj0{s}']}")

print("Loaded all subj train dls and vox!\n")

# Validate only on one subject
if multi_subject: 
    subj = subj_list[0] # cant validate on the actual held out person so picking first in subj_list
test_dl = torch.utils.data.DataLoader(test_data, batch_size=24, shuffle=False, drop_last=True, pin_memory=True)

print(f"Loaded test dl for subj{subj}!\n")


# ## Load models

# ### CLIP image embeddings  model

# In[36]:


## USING OpenCLIP ViT-bigG ###
sys.path.append('generative_models/')
import sgm
from generative_models.sgm.modules.encoders.modules import FrozenOpenCLIPImageEmbedder
# from generative_models.sgm.models.diffusion import DiffusionEngine
# from omegaconf import OmegaConf

try:
    print(clip_img_embedder)
except:
    clip_img_embedder = FrozenOpenCLIPImageEmbedder(
        arch="ViT-bigG-14",
        version="laion2b_s39b_b160k",
        output_tokens=True,
        only_tokens=True,
    )
    clip_img_embedder.to(device)
clip_seq_dim = 256
clip_emb_dim = 1664

# ## USING OPEN AI CLIP ViT-L ###
# import clip
# try:
#     print(clip_model)
# except:
#     clip_model, preprocess = clip.load("ViT-L/14", device=device)
#     preprocess = transforms.Compose([
#         transforms.Resize(224, interpolation=transforms.InterpolationMode.BILINEAR),
#         transforms.Normalize(mean=[0.48145466, 0.4578275, 0.40821073],
#                              std=[0.26862954, 0.26130258, 0.27577711]),
#     ])
# def clip_img_embedder(image):
#     preproc_img = preprocess(image)
#     return clip_model.encode_image(preproc_img)
# clip_seq_dim = 1
# clip_emb_dim = 768


# ### MindEye modules

# In[37]:


model = utils.prepare_model_and_training(
    num_voxels_list=num_voxels_list,
    n_blocks=n_blocks,
    hidden_dim=hidden_dim,
    clip_emb_dim=clip_emb_dim,
    clip_seq_dim=clip_seq_dim,
    use_prior=use_prior,
    clip_scale=clip_scale
)


# In[38]:


# test on subject 1 with fake data
b = torch.randn((2,1,num_voxels_list[0]))
print(b.shape, model.ridge(b,0).shape)


# In[39]:


# test that the model works on some fake data
b = torch.randn((2,1,hidden_dim))
print("b.shape",b.shape)

backbone_, clip_, blur_ = model.backbone(b)
print(backbone_.shape, clip_.shape, blur_[0].shape, blur_[1].shape)


# ### Adding diffusion prior + unCLIP if use_prior=True

# In[40]:


if use_prior:
    from models import *

    # setup diffusion prior network
    out_dim = clip_emb_dim
    depth = 6
    dim_head = 52
    heads = clip_emb_dim//52 # heads * dim_head = clip_emb_dim
    timesteps = 100

    prior_network = VersatileDiffusionPriorNetwork(
            dim=out_dim,
            depth=depth,
            dim_head=dim_head,
            heads=heads,
            causal=False,
            num_tokens = clip_seq_dim,
            learned_query_mode="pos_emb"
        )

    model.diffusion_prior = BrainDiffusionPrior(
        net=prior_network,
        image_embed_dim=out_dim,
        condition_on_text_encodings=False,
        timesteps=timesteps,
        cond_drop_prob=0.2,
        image_embed_scale=None,
    )
    
    utils.count_params(model.diffusion_prior)
    utils.count_params(model)


# ### Setup optimizer / lr / ckpt saving

# In[41]:


no_decay = ['bias', 'LayerNorm.bias', 'LayerNorm.weight']

opt_grouped_parameters = [
    {'params': [p for n, p in model.ridge.named_parameters()], 'weight_decay': 1e-2},
    {'params': [p for n, p in model.backbone.named_parameters() if not any(nd in n for nd in no_decay)], 'weight_decay': 1e-2},
    {'params': [p for n, p in model.backbone.named_parameters() if any(nd in n for nd in no_decay)], 'weight_decay': 0.0},
]
# model.backbone.requires_grad_(False)

if use_prior:
    opt_grouped_parameters.extend([
        {'params': [p for n, p in model.diffusion_prior.named_parameters() if not any(nd in n for nd in no_decay)], 'weight_decay': 1e-2},
        {'params': [p for n, p in model.diffusion_prior.named_parameters() if any(nd in n for nd in no_decay)], 'weight_decay': 0.0}
    ])

optimizer = torch.optim.AdamW(opt_grouped_parameters, lr=max_lr)

if lr_scheduler_type == 'linear':
    lr_scheduler = torch.optim.lr_scheduler.LinearLR(
        optimizer,
        total_iters=int(np.floor(num_epochs*num_iterations_per_epoch)),
        last_epoch=-1
    )
elif lr_scheduler_type == 'cycle':
    if num_iterations_per_epoch==0:
        num_iterations_per_epoch=1
    total_steps=int(np.floor(num_epochs*num_iterations_per_epoch))
    print("total_steps", total_steps)
    lr_scheduler = torch.optim.lr_scheduler.OneCycleLR(
        optimizer, 
        max_lr=max_lr,
        total_steps=total_steps,
        final_div_factor=1000,
        last_epoch=-1, pct_start=2/num_epochs
    )
    
def save_ckpt(tag):
    ckpt_path = outdir+f'/{tag}.pth'
    if accelerator.is_main_process:
        unwrapped_model = accelerator.unwrap_model(model)
        torch.save({
            'epoch': epoch,
            'model_state_dict': unwrapped_model.state_dict(),
            'optimizer_state_dict': optimizer.state_dict(),
            'lr_scheduler': lr_scheduler.state_dict(),
            'train_losses': losses,
            'test_losses': test_losses,
            'lrs': lrs,
            }, ckpt_path)
    print(f"\n---saved {outdir}/{tag} ckpt!---\n")

def load_ckpt(tag,load_lr=True,load_optimizer=True,load_epoch=True,strict=True,outdir=outdir,multisubj_loading=False): 
    print(f"\n---loading {outdir}/{tag}.pth ckpt---\n")
    checkpoint = torch.load(outdir+'/last.pth', map_location='cpu')
    state_dict = checkpoint['model_state_dict']
    if multisubj_loading: # remove incompatible ridge layer that will otherwise error
        state_dict.pop('ridge.linears.0.weight',None)
    model.load_state_dict(state_dict, strict=strict)
    if load_epoch:
        globals()["epoch"] = checkpoint['epoch']
        print("Epoch",epoch)
    if load_optimizer:
        optimizer.load_state_dict(checkpoint['optimizer_state_dict'])
    if load_lr:
        lr_scheduler.load_state_dict(checkpoint['lr_scheduler'])
    del checkpoint

print("\nDone with model preparations!")
num_params = utils.count_params(model)


# # Wandb

# In[42]:


if local_rank==0 and wandb_log: # only use main process for wandb logging
    import wandb
    import time
    
    wandb_project = 'rtmindeye'
    print(f"wandb {wandb_project} run {model_name}")

    # Need to configure wandb beforehand in terminal with "wandb init"!
    wandb_config = {
        "model_name": model_name,
        "global_batch_size": global_batch_size,
        "batch_size": batch_size,
        "num_epochs": num_epochs,
        "num_sessions": num_sessions,
        "num_params": num_params,
        "clip_scale": clip_scale,
        "prior_scale": prior_scale,
        "blur_scale": blur_scale,
        "use_image_aug": use_image_aug,
        "max_lr": max_lr,
        "mixup_pct": mixup_pct,
        "num_samples_per_epoch": num_samples_per_epoch,
        "ckpt_interval": ckpt_interval,
        "ckpt_saving": ckpt_saving,
        "seed": seed,  # SLURM array task ID
        "distributed": distributed,
        "num_devices": num_devices,
        "world_size": world_size,
    }
    print("wandb_config:\n", wandb_config)
    print("wandb_id:", model_name)

    # Initialize wandb
    wandb.init(
        id=model_name,
        project=wandb_project,
        name=model_name,
        config=wandb_config,
        resume="allow",
        save_code=True,
    )

    # Get SLURM job & array ID
    slurm_job_id = utils.get_slurm_job()
    slurm_array_id = seed  # seed corresponds to SLURM_ARRAY_TASK_ID

    # Define SLURM log paths
    log_dir = "slurms"
    log_files = [
        f"{log_dir}/{slurm_job_id}_{slurm_array_id}.out",
        f"{log_dir}/{slurm_job_id}_{slurm_array_id}.err",
    ]

    # Ensure logs exist before logging them
    for log_file in log_files:
        wait_time = 0
        while not os.path.exists(log_file) and wait_time < 60:  # Wait max 60s
            time.sleep(5)
            wait_time += 5

    # Log SLURM logs as artifacts
    artifact = wandb.Artifact(f"slurm_logs_{slurm_job_id}_{slurm_array_id}", type="logs")
    for log_file in log_files:
        if os.path.exists(log_file):
            artifact.add_file(log_file)

    wandb.log_artifact(artifact)
else:
    wandb_log = False


# # Train the model

# In[43]:


epoch = 0
losses, test_losses, lrs = [], [], []
best_test_loss = 1e9
torch.cuda.empty_cache()


# In[44]:


# load multisubject stage1 ckpt if set
if multisubject_ckpt is not None and not resume_from_ckpt:
    load_ckpt("last",outdir=multisubject_ckpt,load_lr=False,load_optimizer=False,load_epoch=False,strict=False,multisubj_loading=True)


# In[45]:


# checkpoint = torch.load(multisubject_ckpt+'/last.pth', map_location='cpu')
# state_dict = checkpoint['model_state_dict']
# model.load_state_dict(state_dict, strict=False)


# In[46]:


# train_dls = [train_dl[f'subj0{s}'] for s in subj_list]

model, optimizer, train_dl, lr_scheduler = accelerator.prepare(model, optimizer, train_dl, lr_scheduler)
# leaving out test_dl since we will only have local_rank 0 device do evals


# In[56]:


print(f"{model_name} starting with epoch {epoch} / {num_epochs}")
progress_bar = tqdm(range(epoch,num_epochs), ncols=1200, disable=(local_rank!=0))
test_image, test_voxel = None, None
mse = nn.MSELoss()
l1 = nn.L1Loss()
soft_loss_temps = utils.cosine_anneal(0.004, 0.0075, num_epochs - int(mixup_pct * num_epochs))
skip_train = True if epoch>=(num_epochs-1) else False # skip training if you are resuming from a fully trained model

for epoch in progress_bar:
    model.train()

    fwd_percent_correct = 0.
    bwd_percent_correct = 0.
    test_fwd_percent_correct = 0.
    test_bwd_percent_correct = 0.
    
    recon_cossim = 0.
    test_recon_cossim = 0.
    recon_mse = 0.
    test_recon_mse = 0.

    loss_clip_total = 0.
    loss_blurry_total = 0.
    loss_blurry_cont_total = 0.
    test_loss_clip_total = 0.
    
    loss_prior_total = 0.
    test_loss_prior_total = 0.

    blurry_pixcorr = 0.
    test_blurry_pixcorr = 0. 

    # you now have voxel_iters and image_iters with num_iterations_per_epoch batches each
    for train_i, behav in enumerate(train_dl):  
        with torch.cuda.amp.autocast(dtype=data_type):
            optimizer.zero_grad()
            loss = 0.
            
            behav = behav[0]

            image = images[behav.long().cpu()].to(device)
            voxel = vox[behav.long().cpu()]
            # voxel = (voxel - train_mean) / train_std
            voxel = torch.Tensor(voxel).unsqueeze(1).to(device)

            if use_image_aug: 
                image = img_augment(image)

            clip_target = clip_img_embedder(image)
            assert not torch.any(torch.isnan(clip_target))

            if epoch < int(mixup_pct * num_epochs):
                voxel, perm, betas, select = utils.mixco(voxel)

            voxel_ridge = model.ridge(voxel,0) #[model.ridge(voxel_list[si],si) for si,s in enumerate(subj_list)]
            # voxel_ridge = torch.cat(voxel_ridge_list, dim=0)

            backbone, clip_voxels, blurry_image_enc_ = model.backbone(voxel_ridge)

            if clip_scale>0:
                clip_voxels_norm = nn.functional.normalize(clip_voxels.flatten(1), dim=-1)
                clip_target_norm = nn.functional.normalize(clip_target.flatten(1), dim=-1)

            if use_prior:
                loss_prior, prior_out = model.diffusion_prior(text_embed=backbone, image_embed=clip_target)
                loss_prior_total += loss_prior.item()
                loss_prior *= prior_scale
                loss += loss_prior

                recon_cossim += nn.functional.cosine_similarity(prior_out, clip_target).mean().item()
                recon_mse += mse(prior_out, clip_target).item()

            if clip_scale>0:
                if epoch < int(mixup_pct * num_epochs):                
                    loss_clip = utils.mixco_nce(
                        clip_voxels_norm,
                        clip_target_norm,
                        temp=.006,
                        perm=perm, betas=betas, select=select)
                else:
                    epoch_temp = soft_loss_temps[epoch-int(mixup_pct*num_epochs)]
                    loss_clip = utils.soft_clip_loss(
                        clip_voxels_norm,
                        clip_target_norm,
                        temp=epoch_temp)

                loss_clip_total += loss_clip.item()
                loss_clip *= clip_scale
                loss += loss_clip

            if blurry_recon:     
                image_enc_pred, transformer_feats = blurry_image_enc_

                image_enc = autoenc.encode(2*image-1).latent_dist.mode() * 0.18215
                loss_blurry = l1(image_enc_pred, image_enc)
                loss_blurry_total += loss_blurry.item()

                if epoch < int(mixup_pct * num_epochs):
                    image_enc_shuf = image_enc[perm]
                    betas_shape = [-1] + [1]*(len(image_enc.shape)-1)
                    image_enc[select] = image_enc[select] * betas[select].reshape(*betas_shape) + \
                        image_enc_shuf[select] * (1 - betas[select]).reshape(*betas_shape)

                image_norm = (image - mean)/std
                image_aug = (blur_augs(image) - mean)/std
                _, cnx_embeds = cnx(image_norm)
                _, cnx_aug_embeds = cnx(image_aug)

                cont_loss = utils.soft_cont_loss(
                    nn.functional.normalize(transformer_feats.reshape(-1, transformer_feats.shape[-1]), dim=-1),
                    nn.functional.normalize(cnx_embeds.reshape(-1, cnx_embeds.shape[-1]), dim=-1),
                    nn.functional.normalize(cnx_aug_embeds.reshape(-1, cnx_embeds.shape[-1]), dim=-1),
                    temp=0.2)
                loss_blurry_cont_total += cont_loss.item()

                loss += (loss_blurry + 0.1*cont_loss) * blur_scale #/.18215

            if clip_scale>0:
                # forward and backward top 1 accuracy        
                labels = torch.arange(len(clip_voxels_norm)).to(clip_voxels_norm.device) 
                fwd_percent_correct += utils.topk(utils.batchwise_cosine_similarity(clip_voxels_norm, clip_target_norm), labels, k=1).item()
                bwd_percent_correct += utils.topk(utils.batchwise_cosine_similarity(clip_target_norm, clip_voxels_norm), labels, k=1).item()

            if blurry_recon:
                with torch.no_grad():
                    # only doing pixcorr eval on a subset of the samples per batch because its costly & slow to compute autoenc.decode()
                    random_samps = np.random.choice(np.arange(len(image)), size=len(image)//5, replace=False)
                    blurry_recon_images = (autoenc.decode(image_enc_pred[random_samps]/0.18215).sample/ 2 + 0.5).clamp(0,1)
                    pixcorr = utils.pixcorr(image[random_samps], blurry_recon_images)
                    blurry_pixcorr += pixcorr.item()
            
            utils.check_loss(loss)
            accelerator.backward(loss)
            optimizer.step()

            losses.append(loss.item())
            lrs.append(optimizer.param_groups[0]['lr'])

            if lr_scheduler_type is not None:
                lr_scheduler.step()
                
            if train_i >= num_iterations_per_epoch-1:
                break
                
    model.eval()
    logs = {}

    if local_rank == 0:
        with torch.no_grad(), torch.cuda.amp.autocast(dtype=data_type):
            for i in range(1):
                for j in range(2):
                    subset_indices = MST_idx[:, i, j].reshape(-1)
                    subset_dataset = torch.utils.data.TensorDataset(torch.tensor(subset_indices))
                    subset_dl = torch.utils.data.DataLoader(
                        subset_dataset, batch_size=24, shuffle=False,
                        drop_last=True, pin_memory=True
                    )

                    # Reset metrics for this subset
                    test_losses = []
                    test_loss_clip_total = 0
                    test_loss_prior_total = 0
                    test_blurry_pixcorr = 0
                    test_fwd_percent_correct = 0
                    test_bwd_percent_correct = 0
                    test_recon_cossim = 0
                    test_recon_mse = 0

                    for test_i, behav in enumerate(subset_dl):
                        behav = behav[0]
                        loss = 0.

                        if behav.ndim > 1:
                            image = images[behav[:, 0].long().cpu()].to(device)
                            voxel = vox[behav.long().cpu()].mean(1)
                        else:
                            image = images[behav.long().cpu()].to(device)
                            voxel = vox[behav.long().cpu()]

                        voxel = torch.Tensor(voxel).unsqueeze(1).to(device)

                        clip_img_embedder = clip_img_embedder.to(device)
                        clip_target = clip_img_embedder(image.float())

                        voxel_ridge = model.ridge(voxel, 0)
                        backbone, clip_voxels, blurry_image_enc_ = model.backbone(voxel_ridge)

                        if clip_scale > 0:
                            clip_voxels_norm = nn.functional.normalize(clip_voxels.flatten(1), dim=-1)
                            clip_target_norm = nn.functional.normalize(clip_target.flatten(1), dim=-1)

                        random_samps = np.random.choice(np.arange(len(image)), size=len(image) // 5, replace=False)

                        if use_prior:
                            loss_prior, contaminated_prior_out = model.diffusion_prior(
                                text_embed=backbone[random_samps], image_embed=clip_target[random_samps])
                            test_loss_prior_total += loss_prior.item()
                            loss_prior *= prior_scale
                            loss += loss_prior

                        if clip_scale > 0:
                            loss_clip = utils.soft_clip_loss(
                                clip_voxels_norm,
                                clip_target_norm,
                                temp=0.006
                            )
                            test_loss_clip_total += loss_clip.item()
                            loss_clip *= clip_scale
                            loss += loss_clip

                        if blurry_recon:
                            image_enc_pred, _ = blurry_image_enc_
                            blurry_recon_images = (autoenc.decode(image_enc_pred[random_samps] / 0.18215).sample / 2 + 0.5).clamp(0, 1)
                            pixcorr = utils.pixcorr(image[random_samps], blurry_recon_images)
                            test_blurry_pixcorr += pixcorr.item()

                        if clip_scale > 0:
                            labels = torch.arange(len(clip_voxels_norm)).to(clip_voxels_norm.device)
                            test_fwd_percent_correct += utils.topk(utils.batchwise_cosine_similarity(clip_voxels_norm, clip_target_norm), labels, k=1).item()
                            test_bwd_percent_correct += utils.topk(utils.batchwise_cosine_similarity(clip_target_norm, clip_voxels_norm), labels, k=1).item()

                        utils.check_loss(loss)
                        test_losses.append(loss.item())

                    logs.update({
                        f"subset_{i}_{j}_test/loss": np.mean(test_losses),
                        f"subset_{i}_{j}_test/loss_clip_total": test_loss_clip_total / (test_i + 1),
                        f"subset_{i}_{j}_test/loss_prior": test_loss_prior_total / (test_i + 1),
                        f"subset_{i}_{j}_test/blurry_pixcorr": test_blurry_pixcorr / (test_i + 1),
                        f"subset_{i}_{j}_test/fwd_pct_correct": test_fwd_percent_correct / (test_i + 1),
                        f"subset_{i}_{j}_test/bwd_pct_correct": test_bwd_percent_correct / (test_i + 1),
                    })
                    print(f"--- Subset ({i},{j}) ---")
                    for k, v in logs.items():
                        if f"subset_{i}_{j}" in k:
                            print(f"{k}: {v:.4f}")

            # After subset loop: add train (and global test, if you want) metrics
            logs.update({
                "train/loss": np.mean(losses[-(train_i+1):]),
                "train/lr": lrs[-1],
                "train/num_steps": len(losses),
                "train/fwd_pct_correct": fwd_percent_correct / (train_i + 1),
                "train/bwd_pct_correct": bwd_percent_correct / (train_i + 1),
                "train/loss_clip_total": loss_clip_total / (train_i + 1),
                "train/loss_blurry_total": loss_blurry_total / (train_i + 1),
                "train/loss_blurry_cont_total": loss_blurry_cont_total / (train_i + 1),
                "train/blurry_pixcorr": blurry_pixcorr / (train_i + 1),
                "train/recon_cossim": recon_cossim / (train_i + 1),
                "train/recon_mse": recon_mse / (train_i + 1),
                "train/loss_prior": loss_prior_total / (train_i + 1),
            })


            # if finished training, save jpg recons if they exist
            if (epoch == num_epochs-1) or (epoch % ckpt_interval == 0):
                if blurry_recon:    
                    image_enc = autoenc.encode(2*image[:4]-1).latent_dist.mode() * 0.18215
                    # transform blurry recon latents to images and plot it
                    fig, axes = plt.subplots(1, 8, figsize=(10, 4))
                    jj=-1
                    for j in [0,1,2,3]:
                        jj+=1
                        axes[jj].imshow(utils.torch_to_Image((autoenc.decode(image_enc[[j]]/0.18215).sample / 2 + 0.5).clamp(0,1)))
                        axes[jj].axis('off')
                        jj+=1
                        axes[jj].imshow(utils.torch_to_Image((autoenc.decode(image_enc_pred[[j]]/0.18215).sample / 2 + 0.5).clamp(0,1)))
                        axes[jj].axis('off')
                    plt.show()

            progress_bar.set_postfix(**logs)

            if wandb_log: wandb.log(logs)
            
    # Save model checkpoint and reconstruct
    if (ckpt_saving) and (epoch % ckpt_interval == 0):
        save_ckpt(f'last')

    # wait for other GPUs to catch up if needed
    accelerator.wait_for_everyone()
    torch.cuda.empty_cache()

print("\n===Finished!===\n")
if ckpt_saving:
    save_ckpt(f'last')


# In[48]:


len(test_data)


# In[49]:


# # Track metrics here:
# https://docs.google.com/spreadsheets/d/1-dbmr4ovl2-4-MFNAL1DqLS651KM_ihjDkkUeP1kHXs/edit?gid=1494588999#gid=1494588999


# **To tell if the model is working I'm looking at test_bwd/fwd_pct_correct and seeing if that is doing better than chance (1/batch_size)**

# In[50]:


# MST_pairmate_names


# In[51]:


x = [im for im in image_names if str(im) not in ('blank.jpg', 'nan')]
assert len(image_idx) == len(x)
pairs = np.empty(shape=MST_pairmate_names.shape, dtype=int)
for i, p in enumerate(MST_pairmate_names):
    assert p[0] != p[1]  # no duplicate images
    pairs[i,0] = x.index(p[0])
    pairs[i,1] = x.index(p[1])
    
# print(pairs)


# In[52]:


# if sub=="sub-002":
#     unique_images_pairs = [
#         (2,3),(4,5),(7,8),(15,16),
#         (483, 484), (485, 486), (487, 488), (491, 492), (495, 496), (499, 500), (501, 502),
#         (503, 504), (512, 513), 
#     ]
# elif sub != 'sub-001' and session != 'ses-05':
#     unique_images_pairs = [
#         (1,2),(3,4),(5,6),(7,8),(9,10),(11,12),(13,14),(15,16),
#         (17,18),(19,20),(21,22),(23,24),(25,26),(27,28),(29,30),
#         (31,32),(33,34),(35,36),
#         (787, 788), (789, 790), (791, 792), (793, 794), (795, 796),
#         (797, 798), (799, 800), (801, 802), (803, 804), (805, 806),
#         (807, 808), (809, 810), (811, 812), (813, 814), (815, 816),
#         (817, 818), (819, 820), (821, 822), (823, 824), (825, 826),
#         (827, 828), (829, 830), (831, 832), (833, 834), (835, 836),
#         (837, 838), (839, 840), (841, 842), (843, 844), (845, 846),
#         (847, 848), (849, 850)
#     ]
# else:
#     # unique_images = unique_images[unique_images!='blank.jpg'][:50]
#     unique_images_pairs = find_mst_pairs(x)
# # unique_images[unique_images_pairs]


# In[53]:


def evaluate_mst_pairs(mst_pairs):
    score = 0
    total = 0
    
    with torch.no_grad(), torch.cuda.amp.autocast(dtype=data_type):
        for pair in mst_pairs:
            voxel = vox[image_idx[pair[0]]].to(device)[None]
            voxel = torch.Tensor(voxel).unsqueeze(1).to(device)
            
            imageA = images[image_idx[pair[0]]].to(device)[None]
            imageB = images[image_idx[pair[1]]].to(device)[None]
            
            clip_targetA = clip_img_embedder(imageA.float())
            clip_targetB = clip_img_embedder(imageB.float())
            
            voxel_ridge = model.ridge(voxel,0)
            backbone, clip_voxels, _ = model.backbone(voxel_ridge)
            
            clip_voxels_norm = nn.functional.normalize(clip_voxels.flatten(1), dim=-1)
            clip_targetA_norm = nn.functional.normalize(clip_targetA.flatten(1), dim=-1)
            clip_targetB_norm = nn.functional.normalize(clip_targetB.flatten(1), dim=-1)
            
            if utils.batchwise_cosine_similarity(clip_voxels_norm, clip_targetA_norm) > utils.batchwise_cosine_similarity(clip_voxels_norm, clip_targetB_norm):
                score += 1
            total += 1
            
            voxel = vox[image_idx[pair[1]]].to(device)[None]
            voxel = torch.Tensor(voxel).unsqueeze(1).to(device)
            
            voxel_ridge = model.ridge(voxel,0)
            backbone, clip_voxels, _ = model.backbone(voxel_ridge)
            clip_voxels_norm = nn.functional.normalize(clip_voxels.flatten(1), dim=-1)
            
            if utils.batchwise_cosine_similarity(clip_voxels_norm, clip_targetB_norm) > utils.batchwise_cosine_similarity(clip_voxels_norm, clip_targetA_norm):
                score += 1
            total += 1
            
    return score/total

print(evaluate_mst_pairs(pairs))


# In[55]:


model.eval()
logs = {}
if local_rank == 0:
    with torch.no_grad(), torch.cuda.amp.autocast(dtype=data_type):
        for i in range(1):
            for j in range(2):
                subset_indices = MST_idx[:, i, j].reshape(-1)
                subset_dataset = torch.utils.data.TensorDataset(torch.tensor(subset_indices))
                subset_dl = torch.utils.data.DataLoader(
                    subset_dataset, batch_size=len(MST_idx), shuffle=False,
                    drop_last=True, pin_memory=True
                )

                # Reset metrics for this subset
                test_fwd_percent_correct = 0
                test_bwd_percent_correct = 0

                for test_i, behav in enumerate(subset_dl):
                    behav = behav[0]
                    loss = 0.
                    image = images[behav.long().cpu()].to(device)
                    voxel = vox[behav.long().cpu()]
                    voxel = torch.Tensor(voxel).unsqueeze(1).to(device)
                    clip_img_embedder = clip_img_embedder.to(device)
                    clip_target = clip_img_embedder(image.float())

                    voxel_ridge = model.ridge(voxel, 0)
                    backbone, clip_voxels, blurry_image_enc_ = model.backbone(voxel_ridge)

                    clip_voxels_norm = torch.nn.functional.normalize(clip_voxels, dim=-1)
                    clip_target_norm = torch.nn.functional.normalize(clip_target, dim=-1)

                    if clip_scale > 0:
                        labels = torch.arange(len(clip_voxels_norm)).to(clip_voxels_norm.device)
                        test_fwd_percent_correct += utils.topk(utils.batchwise_cosine_similarity(clip_voxels_norm, clip_target_norm), labels, k=1).item()
                        test_bwd_percent_correct += utils.topk(utils.batchwise_cosine_similarity(clip_target_norm, clip_voxels_norm), labels, k=1).item()
                    print(test_fwd_percent_correct)
                    print(test_bwd_percent_correct)
                    logs.update({
                        f"subset_{i}_{j}_test/fwd_pct_correct": test_fwd_percent_correct / (test_i + 1),
                        f"subset_{i}_{j}_test/bwd_pct_correct": test_bwd_percent_correct / (test_i + 1),
                    })

    print("--- Full Dataset Evaluation ---")
    for k, v in logs.items():
        print(f"{k}: {v:.4f}")


# In[54]:


# Compare first few pairs
for pair in pairs:  # Checking first 2 pairs
    print("Indices in mst_pairs:", pair)
    print("Corresponding filenames:")
    print(f"Image 1: {x[pair[0]]}")
    print(f"Image 2: {x[pair[1]]}\n")


# In[ ]:


# for i in range(len(pairs)):
#     fig, ax = plt.subplots(1, 2, figsize=(10,8))

#     ax[0].imshow(images[pairs[i][0]].permute(1,2,0).numpy())
#     ax[0].set_title(f"Repeat 1")

#     ax[1].imshow(images[pairs[i][1]].permute(1,2,0).numpy())
#     ax[1].set_title(f"Repeat 2")

#     plt.setp(ax, xticks=[], yticks=[])
#     plt.tight_layout()
#     plt.show()


# In[ ]:


# score = 0
# total = 0
# with torch.no_grad(), torch.cuda.amp.autocast(dtype=data_type): 
#     for pair in unique_images_pairs:
#         imageA_idx, imageB_idx = pair
#         imageA_idx = np.where(image_idx == imageA_idx)[0].item()
#         imageB_idx = np.where(image_idx == imageB_idx)[0].item()
        
#         voxel = vox[imageA_idx].to(device)[None]
#         voxel = torch.Tensor(voxel).unsqueeze(1).to(device)
        
#         imageA = images[imageA_idx].to(device)[None]
#         imageB = images[imageB_idx].to(device)[None]

#         clip_targetA = clip_img_embedder(imageA.float())
#         clip_targetB = clip_img_embedder(imageB.float())
        
#         voxel_ridge = model.ridge(voxel,0)
#         backbone, clip_voxels, blurry_image_enc_ = model.backbone(voxel_ridge)

#         clip_voxels_norm = nn.functional.normalize(clip_voxels.flatten(1), dim=-1)
#         clip_targetA_norm = nn.functional.normalize(clip_targetA.flatten(1), dim=-1)
#         clip_targetB_norm = nn.functional.normalize(clip_targetB.flatten(1), dim=-1)

#         cossimA = utils.batchwise_cosine_similarity(clip_voxels_norm, clip_targetA_norm)
#         cossimB = utils.batchwise_cosine_similarity(clip_voxels_norm, clip_targetB_norm)
        
#         if cossimA > cossimB:
#             score += 1
#         total += 1
        
#     for pair in unique_images_pairs:
#         imageA_idx, imageB_idx = pair
#         imageA_idx = np.where(image_idx == imageA_idx)[0].item()
#         imageB_idx = np.where(image_idx == imageB_idx)[0].item()
        
#         voxel = vox[imageB_idx].to(device)[None]
#         voxel = torch.Tensor(voxel).unsqueeze(1).to(device)
        
#         imageA = images[imageA_idx].to(device)[None]
#         imageB = images[imageB_idx].to(device)[None]

#         clip_targetA = clip_img_embedder(imageA.float())
#         clip_targetB = clip_img_embedder(imageB.float())
        
#         voxel_ridge = model.ridge(voxel,0)
#         backbone, clip_voxels, blurry_image_enc_ = model.backbone(voxel_ridge)

#         clip_voxels_norm = nn.functional.normalize(clip_voxels.flatten(1), dim=-1)
#         clip_targetA_norm = nn.functional.normalize(clip_targetA.flatten(1), dim=-1)
#         clip_targetB_norm = nn.functional.normalize(clip_targetB.flatten(1), dim=-1)

#         cossimA = utils.batchwise_cosine_similarity(clip_voxels_norm, clip_targetA_norm)
#         cossimB = utils.batchwise_cosine_similarity(clip_voxels_norm, clip_targetB_norm)
        
#         if cossimB > cossimA:
#             score += 1
#         total += 1

# print(score/total)


# In[ ]:


#display(utils.torch_to_Image(imageA))
#display(utils.torch_to_Image(imageB))


# In[ ]:


# from scipy.stats import binomtest

# total_samples = len(np.array(unique_images_pairs).flatten())
# assert total_samples == 100

# correct_predictions = int((score/total) * total_samples)  # calculate the number of correct predictions
# expected_accuracy = 0.5  # expected accuracy under the null hypothesis

# # Perform the binomial test
# binom_stats = binomtest(correct_predictions, total_samples, expected_accuracy, alternative='greater')
# p_value = binom_stats.pvalue

# # Output the result
# print(f"P-value: {p_value}")
# if p_value < 0.05:
#     print("The decoder's accuracy is significantly better than chance.")
# else:
#     print("The decoder's accuracy is not significantly better than chance.")


# In[ ]: