(CNN) The number of suicides in the United States has been on the rise since 1999 in everyone between the ages of 10 and 74, according to a new report by the Centers for Disease Control and Prevention. 
 
 Researchers at the CDC's National Center for Health Statistics looked at data on cause of death for Americans 10 and older from 1999 to 2014. They also included information on age and race from death certificates. 
 
 In 2014, 13 people out of every 100,000 took their own lives, compared with 10.5 per 100,000 in 1999. The suicide rate increased every year from 1999 to 2014 among both women and men and in every age group except those 75 and older. 
 
 "The increase is broad-based," said Sally C. Curtin, a statistician at the National Center for Health Statistics and lead author of the new report , which was released Thursday. 
 
 Such an increase in suicides could also make prevention efforts more difficult. "If it were just one particular group, you could say 'that is where we need to focus,' " Curtin said. 
 
 The report is the first since 1999 to look at suicide rates among all age groups, she said. 
 
 The number of suicides increased among all racial groups except for black males, who saw an 8% decline in suicide rate from 10.5 to 9.7 per 100,000 between 1999 and 2014, respectively. The largest increases were among American Indians and Alaska Natives; in this group, the suicide rate climbed by 89% among women and 38% among men. Suicide rates among white women and white men increased by 60% and 28%, respectively. 
 
 Although it is difficult to know why suicide rates increased so much among American Indians and Alaska Natives, "they are typically in a lower socioeconomic status than some of the other ethnic and racial groups, and may have greater access to lethal means and be at higher risk of substance use and alcohol use," said Kristin Holland, a behavioral scientist in the CDC's Division of Violence Prevention who was not involved in the current research. 
 
 The suicide rate in 2014 marks a return to 1996, when the rate was also 13 per 100,000. Although the rate fell between 1996 and 1999, it has been steadily increasing since. The pace of increase has also picked up; whereas the suicide rate climbed by about 1% each year between 1999 and 2006, it increased by 2% each year between 2006 and 2014. 
 
 "We are absolutely very concerned that ... suicide is still on the rise," said Dr. Christine Moutier, chief medical officer of the American Foundation for Suicide Prevention, a nonprofit organization that funds suicide research. 
 
 "Our nation has not made the level of investment on a federal level that can have the positive effect on suicide that has happened for the other leading causes of death," such as heart disease and cancer, said Moutier, who was not involved in the current report. Suicide is the 10th leading cause of death in the United States. 
 
 The reasons for the increase in the suicide rate over the past 15 years are many and complex. Whereas there was a big push between the late 1980s and 1990s for health care providers to identify and treat depression and other mental health problems, some of this progress was undone in recent years because of concerns that antidepressants could increase suicide risk, Moutier said. These concerns were driven by controversy around the Food and Drug Administration's decision to give these medications a black box warning about the suicide risk in children, she added. 
 
 The FDA cautioned at the time that children should still be treated for depression but monitored for any signs of suicidal thoughts. 
 
 Another contributor to the rise in suicide rates could be the growing number of overdose deaths from opiate painkillers , which are considered suicide if a medical examiner or coroner determines that they were probably intentional, Moutier said. "Access to lethal means is one of the most significant risk factors for an individual to die by suicide," she added. 
 
 Yet another factor could have been the economic downturn in the late 2000s, Holland said. 
 
 Largest increases in middle-aged and young women 
 
 The report found that men died by suicide more often than women. In 2014, the rate was 20.7 suicides per 100,000 men, compared with 5.8 per 100,000 women. However, there was a 45% increase in the suicide rate in women between 1999 and 2014, whereas the increase among men during that period was 16%. 
 
 The increase in suicide deaths was greater in magnitude for women of all ages compared with men, with the exception of people 75 and older, whose suicide rate fell from 4.5 per 100,000 in 1999 to 4 in 2014. 
 
 Among women ages 10 to 14, the suicide rate increased threefold between 1999 and 2014, from 0.5 to 1.5 per 100,000. Although the rate was higher overall among men in this age group, it did not increase as much during this period, climbing from 1.9 to 2.6 per 100,000. 
 
 This increase among young women could be misleading because the rate itself is "exceedingly low," and only a small number of suicide deaths would be enough to drive it up substantially, Moutier said. "But we certainly have our eye on it," she added. 
 
 Middle-aged women, between 45 and 64, had the highest suicide rate among women in both 1999 and 2014. This age group also had the largest increase in suicide rate: 63%, from 6 to 9.8 per 100,000. The 45-64 age group also had the largest increase in suicide rate among men: 43%, from 20.8 to 29.7 per 100,000. 
 
 Men 75 and older had the highest overall suicide rate, even though it decreased from 42.4 to 38.8 per 100,000 between 1999 and 2014. The total number of suicide deaths was much greater in middle-aged men than this older group because the population of middle-aged men is so much larger, Curtin said. 
 
 A shift in methods of suicide 
 
 In both 1999 and 2014, firearms were the most common method by which men took their own lives, although the proportion of all suicides in men that were firearm-related decreased from 61.7% to 55.4%. Among women, poisoning was the most common method in 2014 and accounted for 34.1% of suicides, down from 36% in 1999. 
 
 Despite the decreases in the proportion of suicides related to firearms and poisonings, these methods are still responsible for the largest number of suicide deaths, Curtin said. And at the same time these deaths have decreased, the rate of suffocation-related suicide, primarily hanging, has increased, from 16.3% to 26% among women and from 19.1% to 26.8% among men. 
 
 "While it is good that rates for firearm- and poisoning-related suicides are decreasing a bit, it is concerning that the rates of suffocation are increasing," Holland said. 
 
 Progress toward preventing suicide 
 
 The fact that suicide rates are increasing among nearly all age groups means that prevention efforts have to be developed for many different settings, Moutier said. More research is needed to determine which factors are putting middle-aged men and women at greatest risk and which of those factors can be targeted and by which groups, she added. 
 
 The CDC is focusing its suicide prevention efforts on finding strategies that can help prevent suicide among middle-aged men because the number of suicide deaths in that group is so high. 
 
 Join the conversation See the latest news and share your comments with CNN Health on Facebook and Twitter. 
 
 "They are a hard group to reach. They do not see health care providers as much as other age groups," Holland said. 
 
 She and her colleagues are testing strategies that combine improving mental health care and increasing screening for mental health problems with programs that promote social connectedness. 
 
 Moutier said she hopes efforts by the American Foundation for Suicide Prevention could be helping to lower suicide rates among people 75 and older. These efforts include educating primary-care doctors, especially those specializing in the elderly, about identifying people at risk of suicide and working to enhance their connections in society and participation in activities. 

 by Sally C. Curtin, M.A., and Margaret Warner, Ph.D., Division of Vital Statistics; and Holly Hedegaard, M.D., M.S.P.H., Office of Analysis and Epidemiology 
 
 PDF Version [PDF - 276 KB] 
 
 The age-adjusted suicide rate in the United States was 24% higher in 2014 than in 1999, and increases were observed for both females and males in all age groups under 75 (1). This NCHS Health E-Stat provides supplemental data on the frequency and rate of suicide among females and males by Hispanic origin and race for 1999 and 2014. 
 
 For females, age-adjusted suicide rates increased between 1999 and 2014 for all racial and ethnic groups except non-Hispanic Asian or Pacific Islanders (API), with the largest percentage increases for non-Hispanic American Indian or Alaska Native (AIAN) females (89%) and non-Hispanic white females (60%) (Figure 1, Table). Suicide rates for non-Hispanic white females increased for all age groups under age 75. The suicide rate for non-Hispanic white females aged 45–64 in 2014 (12.6 per 100,000) was 80% higher compared with 1999 (7.0) and was three to four times higher than for females in other racial and ethnic groups. Suicide rates for non-Hispanic black and Hispanic females also increased for those aged 45–64. Although much lower than for other ages, the suicide rate in 2014 for non-Hispanic white females aged 10–14 years (1.7 per 100,000) more than tripled from 1999 (0.5). 
 
 For males, age-adjusted suicide rates increased between 1999 and 2014 by 38% for non-Hispanic AIAN males and by 28% for non-Hispanic white males (Figure 2, Table). In 2014, the suicide rate for non-Hispanic AIAN males aged 25–44 was the highest among all racial and ethnic groups (48.0 per 100,000) and was 60% higher than in 1999 (30.0). Non-Hispanic white males had higher suicide rates in 2014 than in 1999 for all age groups under 75 years, with the greatest percentage increase for those aged 45–64 (59%) and 10–14 (57%). In contrast, non-Hispanic black males were the only racial and ethnic group of either sex to have a lower suicide rate in 2014 (9.7 per 100,000 standard population) compared with 1999 (10.5), an 8% decline. 
 
 Deaths for all causes for non-Hispanic AIAN, non-Hispanic API, and Hispanic persons have been shown to be misclassified to other racial and ethnic groups, resulting in underreporting of these deaths by about 28%, 7%, and 5%, respectively (2,3). Despite this underestimation, these groups are included in this report so that all major Hispanic-origin and race groups are presented. Although the extent and direction of misclassification of suicide deaths is unknown, numbers and rates for these racial and ethnic groups are most likely underreported. Even so, non-Hispanic AIAN persons had among the highest age-adjusted suicide rates in 2014 (along with non-Hispanic white persons) and the highest suicide rates for females and males aged 15–24 and 25–44. A study linking self-reported Hispanic origin and race on censuses and surveys to entries on death certificates is in progress and will provide more current estimates of racial and ethnic misclassification on death certificates. In addition, NCHS, with funding from the Office of Minority Health, U.S. Department of Health and Human Services, is developing Web-based training aimed at improving the reporting of race and Hispanic origin on death certificates. 
 
 Data source and methods 
 
 Data are from the 1999 and 2014 National Vital Statistics Systems’ Multiple Cause of Death files, which are compiled from data provided through the Vital Statistics Cooperative Program (4). Deaths were classified using the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD–10) (5). Suicide deaths were identified with ICD–10 underlying cause of death codes U03, X60–X84, and Y87.0. 
 
 Differences in rates were tested by z test for statistical significance, and all differences discussed were significant at the 0.05 level. Age-adjusted death rates were calculated using the direct method and the 2000 standard population (3). Demographic information comes from death certificates. Population data for 1999 and 2014 are July 1 bridged-race estimates from the Vintage 2014 postcensal series. 
 
 
 
 References 
 
 Suggested citation: Curtin SC, Warner M, Hedegaard H. Suicide rates for females and males by race and ethnicity: United States, 1999 and 2014. NCHS Health E-Stat. National Center for Health Statistics. April 2016. 
 
 Figures 
 
 Figure 1. Age-adjusted suicide rates for females, by race and Hispanic origin: United States, 1999 and 2014 
 
 * Difference in rates between 1999 and 2014 was significant (p < 0.05). 
 
 NOTES: Suicide is identified with ICD-10 codes U03, X60–X84, and Y87.0. Death rates for non-Hispanic American Indian or Alaska Native (AIAN), non-Hispanic Asian or Pacific Islander (API), and Hispanic persons may be underestimated and should be interpreted with caution; see Data source and methods. 
 
 SOURCE: CDC/NCHS, National Vital Statistics System mortality data, 1999 and 2014, available from: CDC WONDER online database. 
 
 Figure 2. Age-adjusted suicide rates for males, by race and Hispanic origin: United States, 1999 and 2014 
 
 * Difference in rates between 1999 and 2014 was significant (p < 0.05). 
 
 NOTES: Suicide is identified with ICD-10 codes U03, X60–X84, and Y87.0. Death rates for non-Hispanic American Indian or Alaska Native (AIAN), non-Hispanic Asian or Pacific Islander (API), and Hispanic persons may be underestimated and should be interpreted with caution; see Data source and methods. 
 
 SOURCE: CDC/NCHS, National Vital Statistics System mortality data, 1999 and 2014, available from: CDC WONDER online database. 
 
 Table 
 
 Table. Number of deaths, death rates by age, and age-adjusted death rates for suicide, by Hispanic origin and race and sex: United States, 1999 and 2014 
 
 [Rates per 100,000 population estimated as of July 1] 
 
 Hispanic origin and race and age (years) Female Male 1999 2014 Percent change in rate, 1999–2014 1999 2014 Percent change in rate, 1999–2014 Number Rate Number Rate Number Rate Number Rate All races1 All ages2 5,741 4.0 9,660 5.8 †45 23,458 17.8 33,113 20.7 †16 10–14 50 0.5 150 1.5 †200 192 1.9 275 2.6 †37 15–24 575 3.0 990 4.6 †53 3,326 16.8 4,089 18.2 †8 25–44 2,359 5.5 3,018 7.2 †31 9,213 21.6 10,257 24.3 †13 45–64 1,868 6.0 4,195 9.8 †63 6,109 20.8 12,099 29.7 †43 65–74 420 4.1 828 5.9 †44 2,051 24.7 3,282 26.6 †8 75 and over 469 4.5 477 4.0 †-11 2,549 42.4 3,106 38.8 †-8 Not stated – * 1 * * 16 * 3 * * Non-Hispanic white3 All ages2 4,914 4.7 8,030 7.5 †60 19,620 20.2 27,368 25.8 †28 10–14 33 0.5 94 1.7 †240 140 2.1 190 3.3 †57 15–24 414 3.4 653 5.4 †59 2,416 19.2 2,842 22.4 †17 25–44 1,981 6.8 2,401 9.8 †44 7,415 25.2 7,867 31.7 †26 45–64 1,678 7.0 3,715 12.6 †80 5,389 >23.4 10,617 37.1 †59 65–74 380 4.6 745 6.9 †50 1,869 27.0 2,983 30.7 †14 75 and over 428 4.8 421 4.5 -6 2,384 45.7 2,865 44.0 -4 Not stated - * 1 * * 6 * 3 * * Non-Hispanic black3 All ages2 294 1.7 455 2.1 †24 1,630 10.5 1,871 9.7 †-8 10–14 7 * 14 * * 22 1.4 39 2.5 †79 15–24 55 2.0 91 2.7 35 408 14.8 426 12.3 †-17 25–44 142 2.5 174 3.0 20 785 15.5 806 15.0 -3 45–64 64 1.9 143 2.7 †42 278 9.8 454 9.8 0 65–74 16 * 22 1.6 * 78 11.7 82 7.7 †-34 75 and over 10 * 10 * * 57 14.1 63 11.0 -22 Not stated - * - * * 2 * - * * Non-Hispanic Asian or Pacific Islander3,4 All ages2 188 3.4 350 3.5 3 457 9.0 804 8.9 -1 10–14 1 * 4 * * 6 * 6 * * 15–24 35 4.1 53 4.3 5 82 9.5 163 12.8 †35 25–44 76 3.8 130 4.1 8 203 10.8 285 9.9 -8 45–64 46 3.9 104 4.3 10 118 11.5 251 12.2 6 65–74 14 * 30 4.6 * 22 10.1 58 10.9 8 75 and over 16 * 29 6.3 * 25 19.4 41 12.7 -35 Not stated - * - * * 1 * - * * Non-Hispanic American Indian or Alaska Native3,5 All ages2 54 4.6 118 8.7 †89 222 19.8 348 27.4 †38 10–14 - * 7 * * 2 * 4 * * 15–24 13 * 34 15.6 * 77 39.1 86 38.2 -2 25–44 29 8.2 56 15.7 †91 102 30.0 168 48.0 †60 45–64 12 * 19 * * 30 14.9 70 22.7 †52 65–74 - * - * * 9 * 11 * * 75 and over - * - * * 2 * 9 * * Not stated - * - * * - * - * * Hispanic6 All ages2 265 1.9 662 2.5 †32 1,430 10.3 2,582 10.3 0 10–14 9 * 31 1.3 * 21 1.4 35 1.4 0 15–24 53 1.8 157 3.4 †89 338 9.9 562 11.5 †16 25–44 121 2.3 247 3.0 †30 671 11.3 1,101 12.6 †12 45–64 59 2.5 185 3.5 †40 263 11.8 640 12.4 5 65–74 10 * 28 2.4 * 63 13.8 127 13.2 -4 75 and over 13 * 14 * * 72 30.2 117 20.6 †-32 Not stated - * - * * 2 * - * * 
 
 † Difference in rates between 1999 and 2014 was significant at p < 0.05. 
 
 - Quantity zero. Missing values for age were not distributed prior to calculating rates. 
 
 * Figure does not meet standards of reliability or precision; based on fewer than 20 cases in the numerator. 
 
 1Includes Hispanic origin not stated. 
 
 2Age-adjusted using the direct method and the standard 2000 population. 
 
 3Race categories are consistent with the 1977 Office of Management and Budget (OMB) standards. In 2014, multiple-race data were reported by 46 states and the District of Columbia; see Technical Notes. The multiple-race data for these reporting areas were bridged to the single-race categories of the 1977 OMB standards for comparability with other reporting areas. 
 
 4Includes Aleuts and Eskimos. 
 
 5Includes Chinese, Filipino, Hawaiian, Japanese, and other Asian or Pacific Islander persons. 
 
 6Persons of Hispanic origin may be of any race. 
 
 NOTE: Suicide deaths are identified with underlying cause-of-death codes U03, X60–X84, and Y87.0 from the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision. 
 
 SOURCE: National Vital Statistics System, Mortality, 1999 and 2014. 

 The U.S. suicide rate has risen sharply over the past decade and a half, according to a federal report released on Friday, prompting new concerns about the effects that rising drug use, an uneven economy and other factors may be having on Americans’ health and well-being. 
 
 Suicide is the 10th leading cause of death in the nation, and unlike more common killers such as heart disease and cancer, it rose in 2014. The suicide rate rose 24% between 1999 and 2014 after a decade and a half of declines, according to the report by the...
– As Canada grapples with a suicide crisis, it seems America may have one on its hands, too. Researchers at the CDC's National Center for Health Statistics on Friday released a report that puts the US suicide rate at 13 per 100,000 people—a 30-year high, per the New York Times. The overall suicide rate rose 24% from 1999 to 2014 after declining in the 15 years prior, with suicides among young girls ages 10 to 14 surging 240%, though such cases are still rare (94 in 2014). An increase was seen in every age group except those over 75. The rate for middle-aged women rose 63%—it jumped 80% for white women of this age—while the rate for middle-aged men spiked 43%. "If it were just one particular group, you could say 'that is where we need to focus," lead author Sally C. Curtin tells CNN. "Exactly where the major influences are—we don't know all of the answers to that yet," a CDC employee adds, per the Wall Street Journal. Some possibilities: chronic medical problems, financial stress during the economic downturn, social isolation, a failure to get treatment for mental-health issues, and more "access to lethal means," including opiates. The suicide rate rose 89% and 38% for Native American women and men of all ages, respectively, but declined by 8% among black men of all ages. The rate also declined for older adults, though men over 75 still have the highest suicide rate overall with 38.8 per 100,000 in 2014. The method of death is also altered: Suicide via hanging and other forms of suffocation rose during the study period to about 26% of all suicides. Men remain most likely to commit suicide using a gun, and women using poison.