Angelina Jolie looked movie made-up ready when her and Knox Jolie-Pitt appeared on their Venice balcony following the absurd rumors from the National Enquirer that Knox and his twin sister Vivienne have Down Syndrome. Other than the fact these kids show no outward markers of the disease, they are fraternal twins who don’t share the same exact chromosomes or DNA. The chances of them both having DS is off-the-charts rare. Want to know how rare? 
 
 
 
 Just a quick back-of-the-hand calculation (keep in mind I’m not a doctor or mathematician): Per the National Institute of Health, a 35-year-old woman has a 1 in 400 chance of having a child with DS, which means, mathematically, there is 0.000625 percent chance that both twins, with different DNA, would have DS. And Angelina was only 33 when she gave birth to the twins, making it even more rare. So if you believe this story, I have another one for you: Suri Cruise is part alien from a specimen Tom Cruise stole from Scientology headquarters. 
 
 Photo: INFPhoto.com 

 BRAD PITT and ANGELINA JOLIE's heartbreaking new family crisis - tormented by speculation their 21-month-old twins are suffering from Down syndrome. 
 
 
 
 The Hollywood superstars are grappling with online chatter about babies Knox and Vivienne, and bloggers say the children appear to have the developmental disorder. 
 
 
 
 Children with the Down syndrome genetic disorder are detected by developmental delays -- physical characteristics, include rounded face, flattened profiles and upward slanted eyes. 
 
 
 
 And it's those descriptions that have sparked the false online speculation. 
 
 
 
 "Brad and Angie would subtly try to degstimatize the issue by not hiding them," a close family friend said. 
 
 
 
 For the truth about the Brangie Twins pick up the new ENQUIRER on sale now! 
 

– Taking a break from the tawdry affairs of Democrats, the National Enquirer turns its, er, unique brand of investigative journalism to Down Syndrome and the important unanswerable question of whether two pint-size Jolie-Pitts, Knox and Vivienne, have it. The cover-worthy story, it seems, is that Brad Pitt and Angelina Jolie are "tormented by speculation" in the blogosphere that the twins have physical traits—rounded face, flattened profiles and upward slanted eyes—typical of people with Down Syndrome, and therefore must have Down Syndrome. Put a lid on it, Enquirer, writes a blogger on Babble. "Other than the fact these kids show no outward markers of the disease, they are fraternal twins who don’t share the same exact chromosomes or DNA. The chances of them both having DS is off-the-charts rare," she writes. About "a 0.000625% chance, " to be specific.