text:
Platelet count was significantly lower in PVE patients caused by
Platelet count was significantly lower in PVE patients caused by S. aureus (p = 0.039). HT was more common and hemoglobin level was lower in the S. aureus group, but no statistically significant differences were identified (67% vs. 35%, p = 0.169; 11.2 mg/dL vs. 9.4 mg/dL, p = 0.050, respectively). Table 4 Comparison
between stroke patients caused by PH-797804 mw Staphylococcus aureus and other Inhibitors,research,lifescience,medical organisms Discussion The current study demonstrated that 1) embolic stroke was seen in about a quarter of patients with PVE (26/111 patients, 23%), 2) nearly half of embolic strokes in PVE patients were accompanied by HT (11/26 patients, 42%), 3) in-hospital mortality of PVE patients with embolic stroke was 15% (4/26 patients), 4) in-hospital mortality appeared higher in patients with HT compared to those without HT (27% vs. 7%), although statistically significant differences were not identified likely due to the limited Inhibitors,research,lifescience,medical number of patients identified for study, and 5) predictors for HT of ischemic stroke were not identified from the present study, even though we recruited patients through a multicenter study. Stroke remains a debilitating complication
of left-sided IE in 20-40% of patients and has been associated with poor outcomes.17) In the present study, stroke was seen in 23% of PVE patients, a proportion similar to previous reports of IE patients.9) As a result, Inhibitors,research,lifescience,medical we speculate that the risk of stroke may not be influenced by the type of infected valve (native vs. prosthetic). Not surprisingly, HT was Inhibitors,research,lifescience,medical observed in nearly half of embolic patients as prior evidence demonstrated increased frequency of HT in embolic stroke than in non-embolic stroke patients. Mortality rate for our overall data was 11% and 15% in stroke patients. Interestingly,
mortality rate of stroke patients without HT appeared much lower than stroke patients with HT (7% vs. 37%). Therefore, Inhibitors,research,lifescience,medical stroke following IE of mechanical heart valves might represent a poor prognostic factor, specifically when associated with HT. PT values were not different between stroke patients with and without HT both at the onset of IE and at stroke presentation. Although most of the patients with HT had supratherapeutic CYTH4 PT values (PT/INR > 3), HT also occurred in 2 patients with suboptimal PT levels. Therefore, other factors yet to be uncovered may also be associated with the development of HT in PVE. PT levels remained prolonged even after discontinuing anticoagulation in most of our patients – perhaps due to uncontrolled infection – suggesting that the clinical benefits of stopping anticoagulants in PVE patients with elevated PT values remain unknown. In our population, 8 of 11 stroke patients (73%) were complicated with HT at the time of stroke diagnosis, demonstrating the difficulty in preventing HT by discontinuing anticoagulation. IE caused by S. aureus has the worst prognosis and has a high rate of embolic episodes with subsequent neurologic involvement.
The synthesis of MEL is markedly increased at night in all speci
The synthesis of MEL is markedly increased at night in all species studied to date, independent of whether the animal is diurnally or nocturnally active, and the duration of the nocturnal peak is positively related to the duration of the night.5,6 In nonmammalian vertebrates, the rhythmic synthesis and secretion of MEL is the direct
output of the clock located XL184 within the pineal. Inhibitors,research,lifescience,medical In mammals, however, the pineal does not. retain clock and photoreceptive properties. The synthesis of MEL is driven through multisynaptic neural pathways7,8 by the circadian clock located in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is therefore also an output of the circadian clock. MEL is synthesized Inhibitors,research,lifescience,medical from the amino acid tryptophan, which is first converted into 5-hydroxytryptophan by tryptophan hydroxylase, before being decarboxylated into serotonin (5-hydroxytryptamine, 5-HT). From 5-HT, two major enzymatic steps are involved. The first, is N-acetylation by the arylalkylamine-N-acetyltransferase (AA-NAT) to yield Af-acetylserotonin.The regulation of AA-NAT, with Inhibitors,research,lifescience,medical its sharp increase in activity at night, has received considerable attention as a major regulatory step in rhythmic MEL synthesis.9,10 The second step is
the transfer of a methyl group from 5-adenosylmethionine to the 5-hydroxy group of N-acetylserotonin catalyzed by the hydroxyindolc O-methyltransferase (HIOMT),to yield MEL.11 The rapid Inhibitors,research,lifescience,medical 6-hydroxylation of MEL in the liver means that. it. has a short half-life in the circulation and, therefore, the circulating MEL concentrations precisely reflect its pineal synthesis. MEL is produced primarily by the pineal gland. However, numerous other MEL sources have been identified. The retina
is an important source in nonmammalian vertebrates: not only is MEL rhythmically synthesized in Inhibitors,research,lifescience,medical this structure, but its release from here also contributes to the nocturnal pattern of circulating MEL. In mammals, MEL synthesis within the retina was demonstrated a long time ago.12 However, it is only since the demonstration of a true circadian release of MEL from the hamster retina in vitro (suggesting the presence of a retinal clock) too that the importance of this structure as an extrapincal source of MEL has been recognized.13 In contrast to nonmammalian vertebrates, mammalian retinal MEL does not contribute to circulating MEL. The Harderian and lachrymal glands, gastrointestinal tract, red blood cells, platelets, and mononuclear cells have also been identified as sites of MEL synthesis. MEL does not seem to be released into the general circulation from these tissues, at least, not under normal physiological conditions.14 Moreover, in these tissues the synthesis of MEL is not rhythmic. The presence of MEL is not restricted to vertebrates. MEL has been found in the head, eyes, optic lobe, and brain of various invertebrates in many taxa.
One of the most common reasons for declining HIV screening is lac
One of the most common reasons for declining HIV screening is lack
of perception of risk for HIV infection [25,28,30,32,35,39-41,50,51],[53,58,61-64]. Due to the high prevalence of reported sexual risk and alcohol misuse by ED patients, many techniques have been utilized, with mixed results, to increase uptake of HIV screening, including opt-out HIV screening [36,45,54-57,60,61,65], financial incentives [66], ED staff or clinician-initiated testing [51,54,67], oral fluid sampling for testing [53], prevention counseling [64], and video or computer-based Inhibitors,research,lifescience,medical interventions [43,68,69]. Although a number of studies have examined alcohol misuse, HIV risk, and HIV screening, there is a paucity of research on the intersection of these issues. One approach to improve HIV screening uptake may be to combine alcohol-related and HIV risk interventions in order to increase self-perceived risk and potentially Inhibitors,research,lifescience,medical increase acceptance of screening among ED patients. Before creating such interventions to improve HIV screening uptake and reduce HIV risk and Inhibitors,research,lifescience,medical alcohol misuse, the interrelationships among alcohol misuse, HIV risk and uptake of HIV screening in the absence of interventions among ED patients
need to be established. Our interests in this study were to examine the intersection of alcohol misuse and sexual risk for HIV in its relationship to HIV screening uptake among ED patients. In particular, our objectives were to determine the association between: (1) reported alcohol misuse and HIV sexual risk behaviors; (2) reported alcohol misuse and HIV screening uptake; and (3) reported sexual risk and HIV screening uptake in Inhibitors,research,lifescience,medical the absence
of any interventions. We hypothesized that those who reported greater alcohol use and sexual risk for Inhibitors,research,lifescience,medical HIV would be more inclined to accept HIV screening. Methods Study design and setting From July 2009 to August 2009, 18- to 64-year-old ED patients were randomly selected for inclusion in this study. This investigation had two components: (1) a cross-sectional study examining the prevalence of alcohol misuse and HIV sexual risk among ED patients, (2) and an examination Casein kinase 1 of opt-in HIV screening in this population. The study was conducted at two academic EDs (Rhode Island Hospital and The GSK1363089 in vitro Miriam Hospital) located in Providence, Rhode Island, that are affiliated with the Alpert Medical School of Brown University. Rhode Island Hospital is a level 1 trauma center, receiving over 100,000 annual adult patient visits, and the Miriam Hospital is a community hospital, receiving over 55,000 annual adult patient visits. The Rhode Island Hospital Institutional Review Board approved this study. Verbal consent was obtained for the cross-sectional component of the study, and written consent was obtained for the HIV testing component.
More severe forms of the disorder require progressive sleep phase
More severe forms of the disorder require progressive sleep phase delay in 3-hour steps round the clock until a satisfactory timing is achieved which then has to be fixed. Additional measures to maintain
the improved sleep schedule include early-morning exposure to bright light and firm agreement with the adolescent to maintain a new pattern of social activities and sleep. Melatonin in the evening might also help. Difficulties achieving and maintaining an improved sleep-wake schedule by these means are compounded Inhibitors,research,lifescience,medical if there is a vested interest in maintaining the abnormal sleep pattern, for example, to avoid school ("motivated sleep phase delay"). Psychological problems, including depression, may well also make successful treatment less likely. Inhibitors,research,lifescience,medical The teenager's reluctance to go to bed earlier and to get up at the required time is often misinterpreted as "typical difficult adolescent behavior" causing trouble in the family. Otherwise the condition might be mistakenly viewed as the usual form of school non attendance, primary depression, or substance misuse. Differential diagnosis of childhood parasomnias Parasomnias are repetitive unusual behaviors or strange experiences
that occur just before, during, or arising Inhibitors,research,lifescience,medical out of sleep, or on waking. The many parasomnias (some primary sleep disorders, others secondary to medical or psychiatric conditions) now officially recognized (over 30 in ICSD-2)
indicate how commonly and in many ways (some subtle, others dramatic) sleep can be disturbed by episodic events. Confusion between the different parasomnias seems to be common. For Inhibitors,research,lifescience,medical example, in pediatric textbook accounts, sleep terrors and nightmares (two very different types of parasomnia) are mistaken for each other. Indeed, sometimes there is a tendency to call any dramatic parasomnia a nightmare. Correct diagnosis is important Inhibitors,research,lifescience,medical because different parasomnias each have their own significance and call for contrasting types of advice and treatment. The following brief account is concerned with the main features to be recognized in reaching the correct diagnosis. Fiiiphasis is placed on just some nearly of the more dramatic parasomnias (namely arousal disorders, nightmares, and sleep-related epileptic seizures) as these often cause most confusion and concern. Detailed accounts of these parasomnias and others are provided elsewhere.24 Often an accurate diagnosis can be made by means of a detailed account of the subjective and objective sequence of events from the onset of the episode to its resolution, and of the circumstances in which the episode occurred, including its duration and timing. Audiovisual recording (including by means of home recording by parents) can be very selleck inhibitor informative and often adds details that are missed in descriptions given in the clinic.
Inertial cavitation is a more violent phenomenon, in which the bu
Inertial cavitation is a more violent phenomenon, in which the bubble grows during the rarefaction phase and then rapidly PD184352 datasheet collapses which leads to its destruction. The collapse is often accompanied by the loss of bubble sphericity and formation of high velocity liquid jets. If the bubble collapse occurs next to a cell, the jets may be powerful enough to cause disruption of the cell membrane Inhibitors,research,lifescience,medical (25),(26). In blood vessels, violently collapsing bubbles can damage the lining of the vessel
wall or even disrupt the vessel altogether. One may assume that the disruption occurs due to bubble growth and corresponding distension of the vessel wall. However, it was shown that most damage occurs Inhibitors,research,lifescience,medical as the bubble rapidly collapses and the vessel wall is bent inward or invaginated, causing high amplitude shear stress (27). Stable cavitation may lead to a phenomenon called "microstreaming" (rapid movement of fluid near the bubble due to its oscillating motion). Microstreaming can produce high shear forces close to the bubble that can disrupt cell membranes and may play a role in ultrasound-enhanced drug or gene delivery when damage to the cell membrane is transient (28). Cavitation activity is the major mechanism that is utilized when mechanical damage to tissue is a goal. At its extreme, when very high rarefactional pressures (> 20 MPa) are used, a cloud of cavitating bubbles can cause
Inhibitors,research,lifescience,medical complete tissue lysis at the focus (29). In such treatments the thermal effect is usually to be avoided, therefore, short bursts of very high amplitude ultrasound of low frequency (usually below 2 MHz) are used. The time-averaged intensity remains low, and the thermal dose delivered to the tissue is not sufficient to cause thermal damage. Cavitation can also promote heating if longer HIFU pulses or Inhibitors,research,lifescience,medical continuous ultrasound is used (30)-(32). The energy of the incident ultrasound wave is transferred very efficiently into stable oscillation of resonant-size bubbles. This oscillatory motion causes microstreaming around the bubbles and that, in turn, leads to additional Inhibitors,research,lifescience,medical tissue heating through
viscous friction, which can lead to coagulative necrosis. Cediranib (AZD2171) Nonlinear ultrasound propagation effects Nonlinear effects of ultrasound propagation are observed at high acoustic intensities and manifest themselves as distortion of the pressure waveform: a sinusoidal wave initially generated by an ultrasound transducer becomes sawtooth-shaped as it propagates through water or tissue (Figure 2D). This distortion represents the conversion of energy contained in the fundamental frequency to higher harmonics that are more rapidly absorbed in tissue since ultrasound absorption coefficient increases with frequency. As a result, tissue is heated much faster than it would if nonlinear effects did not occur. Therefore, it is critical to account for nonlinear effects when estimating a thermal dose that a certain HIFU exposure would deliver.
They do it in order to support
other new patients… I woul
other new patients… I would have wished this support to continue, because most of the patients are too weak and it is going to be difficult for them to survive without this service.' C2 facility G, age 24, patient's brother Other ways of providing support were also reported, Inhibitors,research,lifescience,medical including kitchen gardening initiatives and cooperative income generation. One man, who was running a small shop selling vegetables he had grown, explained how the service had helped him: '[Service staff] advise[d] us to make a group of around 10 people and contribute some little money as members concerned, so
that Inhibitors,research,lifescience,medical when you are in need you go there then get something, or else [they] just teach us some skills–farming, bead making, hand crafts–so that when you are in need of money you either sell cabbages, tomatoes or you just sell your hand crafts as they Inhibitors,research,lifescience,medical taught you.' P5 facility H, age 38, not on ART 3. Spiritual distress a. Description of spiritual distress Illness was often experienced by patients through the lens of their spiritual or religious beliefs: 'After some time I started getting serious drug side effects
Inhibitors,research,lifescience,medical [interviewee breaks down in tears]. I could not overcome the drug side effects and I was tempted to stop, probably by an evil spirit. But with prayers I continued taking the drugs.' P7 facility G, female, age 56, on ART Enzalutamide Although the supportive role of spiritual practices and beliefs was described, patients experienced existential despair and hopelessness and questioned God: 'My biggest worry is about my future. I have no child Inhibitors,research,lifescience,medical enough and my dreams are shuttered down and it hurts lots. It is an innermost pain which I can't explain to anybody. When you see people who have died because of this disease and yet they have been on ARVs and yet they die mysteriously… I feel weighed down and lose hope most often.' P3 facility L, male, age 36, on ART This was reiterated by staff: 'At times when people get sick you realise that there is that tension or tendency of saying that God is away from me because if it were true that God is alive then he would not have let me fall sick in the way that I am. So you will find that there is that kind of antagonism between him and his God.
Home care organizations engage several home care providers, defi
Home care organizations engage several home care providers, defined according to their educational level as registered (home care) nurses, certified nurse assistants and home helps. To facilitate the readability of this paper, we will use the term "nurses" for all these home care providers. Some home care organizations have teams of district selleckchem nurses specialized in palliative care and/or home care technology but in the Netherlands palliative care is part of regular health care, so most clients will be cared for by educated nurses with at least Inhibitors,research,lifescience,medical three or four years of general professional education. Often these nurses
cooperate with the family GP, because he is responsible for the medical care of his patients living at home. The general practitioner often refers patients to home care, although in the Inhibitors,research,lifescience,medical Netherlands a formal needs assessment by an independent assessment agency first has to
be conducted before home care financed via the national insurance can be delivered. In other countries terminally ill patients might be referred to specialist palliative care, but the approach of Dutch government is that palliative care should be part of regular health care, in most cases provided by generalists (GPs and nurses) [17]. In order to guarantee the provision of good palliative Inhibitors,research,lifescience,medical care, GPs and nurses can consult multidisciplinary specialist consulting teams of the Comprehensive Cancer Centres in the Netherlands. Moreover Inhibitors,research,lifescience,medical palliative care has become an important subject in the primary curriculum of GPs and at post-curricular courses for doctors and nurses organized for instance by the Comprehensive Cancer Centres. The definition of Turkish or Moroccan migrants is not dependent on their formal nationality; they might have adopted the Dutch nationality. In this paper we define Turkish or Moroccan migrants as persons who live in the Netherlands but who were born in Turkey or Morocco respectively, or whose parents (or one of their parents) were born in Turkey or Morocco. We defined a 'terminally ill client' as a client suffering from an incurable illness and having a probable life
expectancy of not more than six months. Fossariinae The Inhibitors,research,lifescience,medical central terms 'home care', 'terminally ill clients' and 'Turkish and Moroccan clients' were clearly defined in our questionnaires. Participants In order to recruit nurses and general practitioners who have experience of home care for terminally ill Turkish and Moroccan patients we first established where these migrants are mainly living. Using data from Statistics Netherlands we identified the 30 areas with the largest number of Turkish and Moroccan inhabitants. In order to find general practitioners with experience with these migrant groups, we looked for the addresses of all GP practices located in the 30 relevant areas. As their number was far too large, we searched for addresses of practices within the urban areas with indications of social and economic deprivation in the 30 relevant areas.
Strengths and limitations The present study benefited from a lar
Strengths and limitations The present study benefited from a large sample relative to the fMRI literature. It extends the literature by simultaneously examining
anxious apprehension and anxious arousal, as opposed to examining only one anxiety type or ignoring the distinction. Given that these anxiety types are correlated, inferences based on the measurement of only one anxiety type may not reflect effects specific to that Inhibitors,research,lifescience,medical anxiety type. The study also benefited from statistically controlling comorbid depression, which often confounds studies of anxiety due to shared general distress. Additionally, the present study examined habituation at the level of Syk inhibitor neural activation, which can reveal effects that may cancel out at the level of behavior. However, present findings should be interpreted in the context of some limitations. First, although the present study purposefully
chose Inhibitors,research,lifescience,medical stimuli that would not elicit an extremely strong fear response, in order to foster habituation, the stimuli may not be as relevant to pathological anxiety as stimuli that evoke a much stronger fear response (e.g., spiders for individuals with spider Inhibitors,research,lifescience,medical phobia). Second, it is unclear whether the stimuli used in the present investigation were experienced as threatening, and this may have limited the level of fear experienced by participants. Future research could explore a variety of stimuli that may engage fear
more strongly. Third, the present study interprets the observed habituation in Broca's Inhibitors,research,lifescience,medical area as reflecting habituation in worry. However, it is possible that the activation in Broca's area observed in the present study reflects processes other than, or in addition to, worry. For example, it is possible that Broca's area activation better reflects Inhibitors,research,lifescience,medical engagement in processing of the specific word stimuli, rather than actual verbal rehearsal of worries. Even if true, engagement in word processing may still be driven by worry (e.g., worry about performing the task or word meaning), an inference that seems reasonable given that anxious apprehension moderated this activation. One possible method of differentiating between worry and word Oxymatrine processing specific to the stimuli would be to disentangle block-level and stimulus-specific variance, given that worry should be increased during negative blocks but not necessarily tied to specific stimuli. Although there is jitter in the presentation of words in the present study, the length of the jitter is small compared to the HRF, and the timing of the stimuli (2000 ± 225 msec) is approximately equal to the fMRI sampling rate (TR = 2 sec). In order to differentiate between these signals without aliasing, TR would have to be less than 1 sec or ITI greater than 4 sec.
These data highlight that there is still controversy with the me
These data highlight that there is still controversy with the mechanism of action of polymeric micro- and nanoparticles. PLGA micro- and nanospheres can be used for systemic or mucosal immunization [84–86]. PLGA-based systems are able to be phagocytosed by DCs, even by the oral route [87] and enhance their immunostimulatory capacity [88], leading to the upregulation of maturation markers CD40 and CD80 and release of IL-6. It has been shown that Hp91 synthetic peptide (a peptide that can induce
potent antigen-specific cytotoxic T-lymphocyte responses), both encapsulated or conjugated to the surface of PLGA nanoparticles, is able to activate both human and mouse DCs more potently than the free peptide [88]. Inhibitors,research,lifescience,medical PLGA microspheres
have been extensively studied by our research group. Different synthetic peptides have been entrapped into these microspheres, such as malarial SPf66, and have been administered by subcutaneous, intradermal [89], oral [17], or nasal [90] routes in mice. Microencapsulated SPf66 induced Inhibitors,research,lifescience,medical a superior immune response than the one obtained with the administration of the peptide adjuvanted Inhibitors,research,lifescience,medical with alum and comparable with the response obtained with FCA. In addition, these particles have been administered to Aoutus monkeys leading to high antibody levels and protection against P. falciparum challenge [91]. To our knowledge, only one clinical trial has been carried out using PLGA and synthetic peptides [92]. This phase I study evaluated the safety and immunogenicity of a synthetic HIV peptide (HIV-1 MN V3) administered intramuscularly with alum and a similar product encapsulated into PLGA microspheres administered by the oral route. However, the oral administration of this Inhibitors,research,lifescience,medical vaccine did not trigger significant humoral, cellular, or mucosal immune responses. 2.4. Liposomes Liposomes are synthetic spheres comprised by phospholipid bilayers (Figure 4). According to their structure and size, liposomes can be classified into multilamellar vesicles Inhibitors,research,lifescience,medical (MLV), small unilamellar vesicles (SUV), intermediate unilamellar vesicles (IUV), or large unilamellar vesicles (LUV) [93]. For vaccine delivery, antigens
can be encapsulated into the aqueous core, http://www.selleckchem.com/products/pifithrin-alpha.html integrated in the lipid bilayer or adsorbed on the surface [4]. Figure 4 Scheme of liposomes structure. Antigens are differently incorporated based on their nature. Hydrophilic antigens can be encapsulated into the aqueous core; amphipathic antigens and are integrated into the phospholipid bilayer, and lipidic antigens are adsorbed … The mechanism of action of liposomes is not well defined. Passive targeting, derived of their particulate nature, and tendency to interact with macrophages is likely to be an important factor, particularly for nontargeted liposomes [94]. Among the different lipids available, cationic ones have a better ability to initiate and potentiate the immune response.
2000) However, it has been challenging to replicate previously i
2000). However, it has been challenging to replicate previously identified
candidate gene underlying susceptibility to depression (Lopez-Leon et al. 2008) or explain substantial variance in the phenotype. Genome-wide association studies (GWAS) have been unsuccessful in identifying significant individual genetic variants either (Sullivan et al. 2009; Lewis et al. 2010; Muglia et al. 2010; Shi et al. 2011; Shyn et al. 2011; Wray et al. 2012; Hek et al. 2013; Ripke et al. 2013). These negative findings have led to speculation that depression is particularly heterogeneous both clinically and etiologically, Inhibitors,research,lifescience,medical which could dramatically reduce statistical power to identify causal loci (Craddock et al. 2008). In addition, it is often hypothesized that for complex disorders including major depressive disorders, each individual risk allele only has low contribution, with odds ratio typically in the region of 1.05–1.2 (Mitchell 2012). Inhibitors,research,lifescience,medical Statistical power may be improved by increasing sample size, which is not always feasible; by improving precision of phenotype measurement; Inhibitors,research,lifescience,medical or by combining information from multiple loci such as creating polygenic scores (PS) or taking into account interactions between genes or loci, which may effectively increase the magnitude of the genetic effects. Measurement has proven particularly
challenging for depression-related phenotypes. Psychiatric research emphasizes distinctions between categorical diagnoses (binary phenotypes) and dimensional symptom measures (continuous phenotypes) (Maes et al. 1992; Prisciandaro and Roberts 2009). Because categorical diagnoses better distinguish individuals with true Selleckchem I BET 762 psychopathology, genetic determinants might be easier to identify when contrasting Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical diagnosed cases to healthy controls. However, if the heritability reflects the independent influence of many genes with small effects, the phenotype is likely to be continuously distributed and more closely related to symptom-based measures. If so, using a binary outcome measure dichotomizing a continuous
phenotype reduces statistical power compared to using a dimensional quantitative measure with the same sample size (Helzer et al. 2006; Kraemer 2007), In general, diagnostic and symptom-based measures are highly but not perfectly correlated (Radloff 1977). tuclazepam A second challenge in measuring depression phenotypes is appropriately defining the time period of assessment. Genetic risks are carried throughout life, but the phenotype manifest at any given moment reflects both stable genetic contributions and fluctuating, transient contextual influences. These temporary variations reduce statistical power to detect genotype–phenotype associations (assuming transient contextual influences are independent of genetics). Depression phenotypes in genetic association studies are often assessed at a single time point when symptom measures are used.


Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.
Author:Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, et al.
Association between serum soluble CD14 and IL-8 levels and clinical outcome in primary biliary cholangitis.
Author:Umemura T, Sekiguchi T, Joshita S, Yamazaki T, Fujimori N, Shibata S, Ichikawa Y, Komatsu M, Matsumoto A, Shums Z, Norman GL, Tanaka E, Ota M.
Liver stiffness-spleen size-to-platelet ratio risk score identifies esophageal varices in Japanese patients with chronic hepatitis C.
Author:Shibata S, Umemura T, Yamazaki T, Fujimori N, Ichikawa Y, Kimura T, Joshita S, Komatsu M, Matsumoto A, Tanaka E.
Incidence and prevalence of autoimmune hepatitis in the Ueda area, Japan.
Author:Yoshizawa K, Joshita S, Matsumoto A, Umemura T, Tanaka E, Morita S, Maejima T, Ota M.
Liver stiffness-spleen size-to-platelet ratio risk score detects esophageal varices in chronic liver disease.
Author:Shibata S, Joshita S, Umemura T, Yamazaki T, Fujimori N, Ichikawa Y, Komatsu M, Matsumoto A, Tanaka E.
Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.
Author:Umemura T, Joshita S, Yamazaki T, Komatsu M, Katsuyama Y, Yoshizawa K, Tanaka E, Ota M.
Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection.
Author:Kimura T, Kobayashi A, Tanaka N, Sano K, Komatsu M, Fujimori N, Yamazaki T, Shibata S, Ichikawa Y, Joshita S, Umemura T, Matsumoto A, Horiuchi A, Mori H, Wada S, Kiyosawa K, Miyagawa SI, Tanaka E.
Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection.
Author:Ichikawa Y, Joshita S, Umemura T, Shobugawa Y, Usami Y, Shibata S, Yamazaki T, Fujimori N, Komatsu M, Matsumoto A, Tanaka E.
Lymphocyte Antigen 75 Polymorphisms Are Associated with Disease Susceptibility and Phenotype in Japanese Patients with Inflammatory Bowel Disease.
Author:Hirayama A, Joshita S, Kitahara K, Mukawa K, Suga T, Umemura T, Tanaka E, Ota M.
Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein Level Predicts Liver Fibrosis and Prognosis in Primary Biliary Cirrhosis.
Author:Umemura T, Joshita S, Sekiguchi T, Usami Y, Shibata S, Kimura T, Komatsu M, Matsumoto A, Ota M, Tanaka E.
Serum cell death biomarkers for prediction of liver fibrosis and poor prognosis in primary biliary cirrhosis.
Author:Sekiguchi T, Umemura T, Fujimori N, Shibata S, Ichikawa Y, Kimura T, Joshita S, Komatsu M, Matsumoto A, Tanaka E, Ota M.


text:
Columnist Others Sports Events Japan
Surfing: Japan to Host World Surfing Games on 2019
17/12/2018 01/01/2019 Leandro | Eur-lex.europa.eu eur-lex.europa.eu 458 views 0 comments Asia, Atsushi Sakai, International Surfing Association, Japan, Japan, News, Olympics, Olympics, sports, Surfing, Surfing, Tokyo
The International Surfing Association announced on Sunday that the World Surfing Games will return to Japan next year and will be the first direct qualifiers of the 2020 Tokyo Games, where the sport will make its Olympic debut.
The best-qualified man and woman from Europe, Africa, Asia and Oceania at 7 to 15's 2019 event on Kisakihama beach in Miyazaki province in southeastern Kyushu will automatically qualify for Tokyo 2020.
Surfers of the Americas will qualify based on their results at the 2019 Pan American Games.
It will mark the third consecutive year for ISA to host an international event in Japan.
"Japan has demonstrated its extraordinary organizational capacity by hosting key ISA events, so we are excited and proud to return to this incredible country for the third consecutive year with our flagship event," said ISA President Fernando Aguerre.
"With excellent weather, excellent waves and the warm spirit of the Japanese people, Miyazaki ... will be a great destination to hold this event," he added.
Atsushi Sakai, president of the Nippon Surfing Association, said he is looking forward to giving the world a preview of the athletes who will qualify for Tokyo 2020 and praised Japan's performance at the WSG in September.
"The performance of Japan's gold medal last year was a breakthrough that showed the elite talent we have for the world," Sakai said. "We look forward to defending our title for the first time at home."
At this year's WSG at Pacific Long Beach in Tahara, Aichi Prefecture, Team Japan posted their best result and won the team's first gold medal in the history of World Surfing Games, thanks in part to the Kanoa Igarashi silver medal. .
Igarashi, whose parents moved to California before he was born, changed his competitive nationality earlier this year in hopes of representing Japan in 2020.
Japan, as host nation, will have an automatic spot in each of the 20 Olympic sweepstakes of surfers and will have a chance to win another.
Source: Kyodo News
Leandro | Eur-lex.europa.eu eur-lex.europa.eu
Webmaster, programmer, developer and publisher of articles.
3 killed due to high temperatures continue throughout Japan
28/05/2019 Mokuhyou | ム リ ー リ ョ. Eur-lex.europa.eu eur-lex.europa.eu 0
19% of local assemblies in Japan do not have female members
05/03/2019 Leandro | Eur-lex.europa.eu eur-lex.europa.eu 0
MMA and professional boxing are legalized again in Norway
07/04/2019 Oriosvaldo Costa | Eur-lex.europa.eu eur-lex.europa.eu 0
Save my data in this browser for the next time I comment.

redpajama_set_name: RedPajamaCommonCrawl


text:
Peter George Wood (September 1951 – 26 January 2022) was an English first-class cricketer active in 1981 who played for Nottinghamshire.

He was active in the Lancashire League and was the all-time leading run-maker for Rawtenstall.

Wood died suddenly in Australia on 26 January 2022, at the age of 70.

References

1951 births
2022 deaths
Cumberland cricketers
English cricketers
Nottinghamshire cricketers

redpajama_set_name: RedPajamaWikipedia


text:
Home>Movies & Music>Movies
WORDS, THE (BLU RAY)
Movie & Season No.
Randall Miller
A Thousand Words Blu-ray Region B
Comedy starring Eddie Murphy as a consummate liar who gets his comeuppance. Literary agent Jack McCall (Murphy) has... More info...
Bad Words (Blu Ray)
Bad Words Blu Ray starring Jason Bateman. A spelling bee loser sets out to exact revenge by finding a loophole and... More info...
The Garden Of Words (Blu Ray)
The Garden of Words Blu Ray from DVDLand. When Takao, a young high school student who dreams of becoming a... More info...
The Garden of Words (Blu-ray)
Bad Words (Blu-ray)
Jason Bateman makes his feature directorial debut with the subversive comedy, Bad Words Bateman stars as Guy Trilby,... More info...
Paranormal Activity (Blu-ray)
After a young couple moves into what seems like a typical suburban house, they become increasingly disturbed by a presence... More info...
Signs (Blu-ray)
After captivating audiences with The Sixth Sense and Unbreakable, writer/director M. Night Shyamalan created his... More info...
I Know Who Killed Me (Blu-ray)
Lindsay Lohan stars in this mind-bending psychological thriller. An idyllic town is rocked when Aubrey Fleming (Lohan... More info...
Shooter (2007) (Blu-ray)
From Antoine Fuqua, the director of "Training Day", and starring Academy Award and Golden Globe nominee Mark... More info...
Being Human (2011): North American Season 2 ...
Being Human: nobody ever said it was easy. But when you're a ghost, a vampire and a werewolf, like the three... More info...
Insidious (Blu-ray)
Insidious tells the story of a young family who move into a new home and make a terrifying discovery that science cannot... More info...
Father of the Bride (1991) / Father of the Bride:...
FATHER OF THE BRIDE: In this hilarious update of the much-loved Hollywood classic, Steve Martin turns... More info...
The Walking Dead: Season 2 (Blu-ray)
The record-breaking hit returns for a second powerful series as the fight to stay alive intensifies for Officer Rick... More info...
The Lion King 3 (Blu-ray)
For the first time ever in Blu-ray high definition, hilarity reigns in the motion picture comedy-adventure that takes you... More info...
Hannibal (Blu-ray)
The silence has been broken. . . "Thrilling" (Time), "absorbing" (The Wall Street Journal), and "entertaining" ... More info...
Constantine (Blu-ray)
John Constantine (Keanu Reeves) is a world-travelling, mage-like misfit who investigates supernatural mysteries and the... More info...
10 Things I Hate About You (10th Anniversary...
A cool cast of young stars is just one of the things you'll love about this hilarious comedy hit! On the first day at his new... More info...
Pulp Fiction (Blu-ray)
Vincent Vega and Jules Winnfield are two hitmen on the hunt for a briefcase whose contents were stolen from their... More info...
Black Hawk Down (Blu-ray)
Black Hawk Down drops you into a crowded marketplace in the heart of Mogadishu, Somalia with the U. S. Special... More info...
The Fighter (Blu-ray)
Inspired by the true story of two brothers who against all odds come together to train for a historic title bout that will... More info...
Gattaca (Blu-ray)
Ethan Hawke, Uma Thurman, Alan Arkin and Jude Law star in this engrossing sci-fi thriller about an all-too-human... More info...
The Guardian (2006) (Blu-ray)
An aging USCG rescue swimmers team is killed in a horrific rescue mission. Immediately prior to this terrible event, his... More info...
The Ledge (Blu-ray)
A thriller in which a battle of philosophies between a fundamentalist Christian and an atheist escalates into a lethal... More info...
Solitary Man (Blu-ray)
Michael Douglas stars as a former car dealership owner who sees his personal and professional lives take a nosedive when... More info...
Resident Evil: Extinction (Blu-ray)
Milla Jovovich returns as ass-kicking heroine Alice in this action-packed third instalment in the film series based on the... More info...
Push (Blu-ray)
This non-stop mindbender starts when Cassie, a 13 year old Watcher who can see the future (Dakota Fanning),... More info...
Catch .44 (Blu-ray)
When three friends are sent by their boss to intercept a drug deal at a desolate diner they think nothing of it. . . until a... More info...
Gone In 60 Seconds (Blu-ray)
High-octane superstar Nicolas Cage (Leaving Las Vegas, The Rock, Bringing Out The Dead) and sexy Angelina... More info...
Waterworld (Blu-ray)
Kevin Costner, Dennis Hopper and Jeanne Tripplehorn star in a "10+!" (Gary Franklin, KCOP), turbocharged... More info...
Black Rain (Special Collector's Edition) (Blu-ray)
Director Ridley Scott, who created two of Hollywood's most impactful and stylish adventure thrillers, Alien and... More info...
The Butterfly Effect 3: Revelations (Blu-ray)
Posing as a psychic, Sam Reide travels back in time to witness crimes and identify the killers in the present. He knows... More info...
King Arthur (Director's Cut) (Extended Version) ...
Now, from the producer of Pearl Harbor and the director of Training Day. . . experience the extended unrated director's... More info...
Bodyguards and Assassins (Blu-ray)
Donnie Yen, the star of IP MAN and IP MAN 2 returns in this sensational big budget martial arts epic. Set in... More info...
The Man With No Name Trilogy: A Sergio Leone...
FIST FULL OF DOLLARS The first film in director Sergio Leone and star Clint Eastwood's "Man... More info...
Predator (Ultimate Hunter Edition) (Blu-ray)
Deep in the jungle, several bodies have been discovered skinned and hanging from trees although who or what could have done... More info...
War, Inc. (Blu-ray)
A political satire set in Turaqistan, a country occupied by an American private corporation run by a former US... More info...
Pixar Shorts Film Collection Volume 1 (Blu Ray)
Pixar Shorts Film Collection Volume 1 Blu Ray from DVDLand. Animated Shorts have always been an essential... More info...
The Descent: Part 2 (Blu-ray)
Bloodied and traumatised, Sarah Carter (Shauna Macdonald) emerges alone from the caving trip where she encountered... More info...
Nobel Son (Blu Ray)
Nobel Son Blu Ray from DVDLand. PhD candidate Barkley Michaelson (Greenberg) is a man with a big problem.... More info...
BMO Books
DVD Farewell (Blu-Ray) - Delirious - Special...
Special Order may take up to 6 weeks More info...
Road to Perdition (Blu-ray)
Hit man Michael Sullivan (Tom Hanks), known in his 1930s Chicago world as The Angel of Death, is on the run... More info...
Rumour Has It... (Blu-ray)
Jennifer Aniston plays a woman who learns that her family was the inspiration for the book and film The Graduate - and... More info...
National Treasure 2: Book of Secrets (Blu-ray)
Join Nicolas Cage on a heart-pounding adventure that will have you on the edge of your seat in a race to find the Lost... More info...
The Smurfs (2011) (Blu-ray)
When the evil wizard Gargamel chases the tiny blue Smurfs out of their village, they tumble from their magical world and... More info...
Toy Story 3 (3D Blu-ray/Blu-ray) (Blu-ray)
The toys are mistakenly delivered to a day-care centre instead of the attic right before Andy leaves for college, and it's up... More info...
Sanctum (Blu-ray)
The action-thriller Sanctum from executive producer James Cameron follows a team of underwater cave divers on a... More info...
TT: Closer to the Edge 3D (3D Blu-ray) ...
The Isle of Man Tourist Trophy is the greatest motorcycle road race in the world. Every rider knows that each race... More info...
Ides Of March (Blu Ray)
Ides of March Blu Ray from DVDLand. The Ides of March takes place during the frantic last days before a heavily... More info...
Snow Flower and the Secret Fan (Blu-ray)
Inspired by the bestselling novel by Lisa See, Snow Flower and the Secret Fan tells the story of seven-year-old girls... More info...
Footloose (Blu Ray)
Footloose Blu Ray from DVDLand. Footloose jumps with spirit, dazzling dance numbers and an electrifying musical... More info...
Sinners and Saints (Blu-ray)
As the leader of an elite street crimes task force squad, New Orleans Detective Sean Reilly (Johnny Strong) has seen... More info...
Once Upon a Time in the West (Blu-ray)
Epic story of a mysterious stranger with a harmonica who joins forces with a notorious desperado to protect a beautiful... More info...
Pirates of The Caribbean: Dead Man's Chest (2...
Captain jack Sparrow has a blood debt to pay: He owes his soul to ghastly Davy Jones unless he can cheat death - and... More info...
Alien: Resurrection (Blu-ray)
200 years after the conclusion of Alien 3, the company is able to resurrect Ripley through the process of cloning and... More info...
The Trip (Blu-ray)
When Steve is commissioned to write half a dozen restaurants reviews he decides to plan a trip around England with his... More info...
Valencia Musical Instruments
Thorens Record Players
9347 - Childers QLD Topographic Map
Brave Enough by Cheryl Strayed Deals
Biography Books Online
Celine Dion CD's
CD Turntable
8015 Inglis
Science and Technology of Polymers and Advanced Materials by Paras N. Prasad
Ashton Electric Guitars
Rock CD's
Fishing Maps
Complete Survival Manual
The Margins of City Life by John M. Merriman
Movies prices are provided by the merchants and MyShopping assumes no responsibility for accuracy of price information. Product specifications are obtained from merchants or third parties and although we make every effort to present accurate information, MyShopping is not responsible for inaccuracies.


Keyhole is a Canadian film directed by Guy Maddin, starring Jason Patric, Isabella Rossellini, Udo Kier and Kevin McDonald. It tells the story of a gangster who returns to his home and embarks on an odyssey through the house, one room at a time. Filming began in Winnipeg on July 6, 2010. . .


text:
Q: addressof-operator in c# In a winapi function I have to pass the address of the callback function
that function has to use.
So I declared a unsafe class and everything, but bool* addressofmyfunction = &GetHandle;
just won't compile!
Please help me or give me an alternative to passing the address like this.

A: In .NET delegates are used to store pointers to functions. For example if you have the following function:
public int GetHandle(int arg1)
{
    return arg1 + 10;
}

it's address will be defined like so:
Func<int, int> addressOfMyFunction = GetHandle;

and you can invoke it like that:
int result = addressOfMyFunction(50);

A: bool* addressofmyfunction = &GetHandle won't compile in C or C++ either (the correct syntax would be bool (*addressofmyfunction)() = &GetHandle), but you can't do like that. I'm not an expert in interop, but I think you have to use Marshal.GetFunctionPointerForDelegate.

A: Function pointers are represented by delegates in C#. Since methods aren't moved by the garbage collector, you don't need to pin them (or use unsafe code) to pass them to a Win32 API function.
Example:
using System;
using System.Runtime.InteropServices;

public delegate bool CallBack(int hwnd, int lParam);

public class EnumReportApp {

    [DllImport("user32")]
    public static extern int EnumWindows(CallBack x, int y);

    public static void Main()
    {
        CallBack myCallBack = new CallBack(EnumReportApp.Report);
        EnumWindows(myCallBack, 0);
    }

   public static bool Report(int hwnd, int lParam) {
        Console.Write("Window handle is ");
        Console.WriteLine(hwnd);
        return true;
    }
}

There is a similar example for EnumThreadWindows on pinvoke.net.

redpajama_set_name: RedPajamaStackExchange


If it's not a case on the gig economy making the employment news headlines, it's one on whistleblowing (see, for example, here). And this month is no exception, with the Court of Appeal handing down its decision in Chesterton v Nurmohamed. In a judgment that is undeniably a blow for employers, the Court has considered what it means for a disclosure to be 'in the public interest' and in doing so has set the bar low.
Our blog piece on the EAT decision on Chesterton gives a full background on the facts of the case and on whistleblowing protection in general. Briefly, the EAT was satisfied that although Mr Nurmohamed was mainly concerned with his own financial position when making his disclosures, he also had the other (100 or so) senior managers in mind (whose income would also be affected by the alleged accounting malpractice), which was a sufficient group of the public to engage the public interest. The question the Court of Appeal had to consider was whether the EAT was entitled to find that Mr Nurmohamed made his disclosures in the reasonable belief that they were in the public interest, despite his personal motivations in raising the allegations.
In dismissing Chesterton's appeal, the Court of Appeal has confirmed that a disclosure which is in the private interest of the worker making it, can also be in the 'public interest' because it serves the (private) interests of other workers as well. Cases will, of course, be heavily dependent on the facts but this is noteworthy interpretation.
The Court of Appeal rejected Chesterton's arguments that in order for a disclosure to be in the public interest, the interests served have to 'extend outside the workplace' in the sense that the disclosure furthers the interests of persons other than the workers themselves. Incidentally, the Court of Appeal also rejected the starkly opposite position taken by Public Concern at Work (who were given permission to intervene) that a disclosure could be in the public interest if it is in the interests of anyone else besides the worker making the disclosure. All in all, this seems a logical middle ground.
The numbers in the group whose interests the disclosure served - a disclosure affecting the whole workforce is more likely to be protected than one affecting only one or two workers.
The nature of the interests affected and the extent to which they are affected by the wrongdoing disclosed – a disclosure of wrongdoing directly affecting a very important interest is more likely to be in the public interest than a disclosure of trivial wrongdoing affecting the same number of people.
The nature of the wrongdoing disclosed – disclosure of deliberate wrongdoing is more likely to be in the public interest than disclosure of inadvertent wrongdoing affecting the same number of people.
The identity of the alleged wrongdoer – the larger or more prominent the wrongdoer, the more obviously should a disclosure about its activities engage the public interest.
The Court of Appeal observed that although the accounts in this case (which were the subject of the manipulation) were only internal, if the accounts were the statutory accounts, even of a private company, the disclosure of such a misstatement would unquestionably be in the public interest. The Court of Appeal was also not prepared to rule out the possibility that the disclosure of a breach of a worker's contract (e.g. of the Parkins v Sodexho kind, where there had been a breach of his/her own employment contract) may nevertheless be in the public interest, or reasonably be so regarded, if a sufficiently large number of other employees share the same interest.
However, there is a glimmer of light on this point – the Court of Appeal urged Tribunals to be cautious in cases about breach of individual contracts: on the whole, workers making disclosures in the context of private workplace disputes should not attract the enhanced statutory protection accorded to whistleblowers – even where more than one worker is involved. This at least is helpful: a Tribunal should look behind a worker's concern for his or her fellow workers to determine that it is indeed genuine, rather than an attempt to gain additional protections for what is essentially a private complaint.
What is the practical impact for employers?
This significant Court of Appeal decision is clearly not helpful for employers: to the extent that the public interest test did place an additional obstacle in the way of whistleblowers, the Court of Appeal has set that hurdle at a relatively low (yet fact specific) level. It remains fairly easy for a worker to demonstrate they have a reasonable belief that their disclosure is in the public interest, provided they can show the issues in question affect other individuals too. In addition, a disclosure will not cease to qualify simply because the worker seeks to justify it after the event – as is often the case – by reference to reasons not expressed at the time. The public interest requirement does not even need to be his or her principal motive.
This case is a salutary lesson to employers not to dismiss allegations by employees out of hand just because, on the face of it, they seem to relate to personal circumstances. If there's a chance the allegations could relate to other workers, it's worth stopping to consider if whistleblower protections might apply. While the Court was clear that such protections are not intended to protect those with purely personal complaints, given the penalties at stake, caution is still the wisest approach to take. And as ever, if in doubt, we are happy to give a view.


text:
The photo book particularly is a manifestation of the role of the photographer as a narrator. The unbroken strong, visually narrative power of this medium has meanwhile become an artistic genre of its own and for photographers something like an exhibition between the book cover and the spine.
In a photo book, a photographer can say what he cannot do with a single image and it is not just about what is being told, but especially how. That separates the wheat from the chaff. Not every book full of photos is a photo book.
3books is not about addressing the photo book in its narrative evidence, not finding out which is the best or most important photo book or monograph, but which books were and are personally most important for the individual photographer / artist. Which books have accompanied, inspired and influenced him or her from the beginning or just now, so that you can get a bit of a picture of the photo book world in which the person moves and can also discover the selections as an inspiration for yourself.
According to estimates by Martin Parr, over 1000 photo books are produced annually (Photobook History Vol.II). You never have a complete overview and there are always new and great books to be found, so get inspired!
3 books by Alexandra Lechner
Alexandra Lechner is a photographer in Frankfurt/M. After training as a photographer, she studied...
3 books by andrea diefenbach
Andrea Diefenbach lives as a freelance photographer in Wiesbaden. She studied photography at the...
3 books by heinrich völkel
Heinrich Völkel, born in Moscow in 1974 (mother Russian, father German) and raised in Leipzig,...
3 books by markus hintzen
Markus Hintzen is not a landscape photographer in the classical sense. His metier is actually...
3 books by olaf martens
Born in Halle/S. in 1963, studied photography at the Academy of Visual Arts in Leipzig from 1985...
3 books by hannah feldmeier
I am a graphic designer in my current adopted city of Leipzig. Since 2013 I have been working...
3 books by Andrés Wertheim
Andrés Wertheim was born in Buenos Aires in 1962 and began studying photography with Horacio...
3 books by Peter Nitsch
Peter Nitsch was born in the Upper Palatinate in Eastern Bavaria and spent his childhood there....
3 books by Per Schorn
I grew up in the Wetterau, just far enough from Frankfurt that I couldn't easily drive into the...
3 books by Alex Schwander
I always wanted to be a photographer. This wish was already clear at the end of my school years....
3 books by David Höpfner
David Höpfner was born in Frankfurt am Main and grew up just outside the city in the Taunus...
3 books by Achim Katzberg
Achim Katzberg has lived and worked in the Rhine-Main area since the early 90s. He has lived in...
3 books by frank kunert
Frank Kunert was born in Frankfurt am Main in 1963 and grew up in the Rhine-Main region. He began...
3 books by peter seidel
Born left-handed in Marburg and raised in Frankfurt, Peter Seidel studied German, English and film...


Easy Street Rod and Custom Club's Canton Beach Run was a very successful event this year with about 95 entrants. It is always a great weekend but this year the weather was good, a change of time for the Saturday Show and Shine and a great Saturday night gambling night made the event even better. The club should be applauded for feeding everyone who enters very well for the whole weekend. To Maitland Street Rodders who attended the Saturday Show and Shine, it is always best to reverse into the parking spot but I guess it is not always I get a picture of the rear ends. We will be back again next year and maybe a few more of our members can come for the whole weekend.
This years MAD was the largest ever held with around 800 entrants. The weather was perfect and Ian took the following pictures of the event.


What items would you rrrather have in your zombie apocalypse kit? Sanna 77 (holds 40 rounds of 9x19mm Parabellum and comes with foldable stock), a Mamba Pistol (hold 15 rounds of .30 Luger or 9x19mm Parabellum). Also, an Axe with wooden handle/wood handle axe STO002 or SIG SG 542-1 (holds 20-30 rounds of SG 540, SG 543: 5.56x45mm NATO, or SG 542: 7.62x51mm NATO & is effective from 100-500 meters), a FAMAE FN-750 (a CZ 75 clone that holds 12-26 rounds of	9×19mm Parabellum, 9×21mm, or .40 S&W and is effective from 50 meters), and an ordinary lighter.?
line SIG SG 542-1 (holds 20-30 rounds of SG 540, SG 543: 5.56x45mm NATO, or SG 542: 7.62x51mm NATO & is effective from 100-500 meters), a FAMAE FN-750 (a CZ 75 clone that holds 12-26 rounds of	9×19mm Parabellum, 9×21mm, or .40 S&W and is effective from 50 meters), and an ordinary lighter.
Axes can be used for so much more than just chopping/swinging.
I don't see other usage than chopping zombies or trees.
Sharpening things, starting fires, cutting animals open for cooking, chopping down branches for firewood, etc.
My kit for the zombie apocalypse: 1. http://dailym.ai/1xl5jfr 2. http://bit.ly/1zKOGGG. 3. http://bit.ly/1D47kQa. That's how a modern knight would look like. With those things equipped I'm unstoppable.
The "riot shield" would render quite useless. Also, you should have at least one firearm, no way you can survive with just a katana.
No it wouldn't. You can bash zombies and they fall on the floor. You can also use it as a blockage to hold the zombies in case you get exhausted, and you can see through it as well. And I don't really like ranged weapons personally. Probably shotguns, but not the rest.
More reliable weapons, and that lighter is a life saver.
Axe is the most useful weapon someone could have. Chop down trees. Chop down zombies. Chop down doors. Chop down human beings when they eventually betray you because they don't accept your love and call you creepy. I am not creepy I am just a person who is in love. How dare you call me creepy, Allison!
It's not a big axe like a fire axe, it's more like a hatchet.
I am still upset about Allison. Don't make me more upset about not having a big axe.
At least you won't look like you're over compensating.


On the surface, it might seem like homeowners insurance is unimportant for a vacation home. You probably only spend a few weeks a year in the home. You already have insurance on your primary residence. You might be asking yourself if insurance on your vacation home is really necessary. If you are questioning the importance of insurance on your vacation home, consider a few reasons why it is important.
Many vacation homes are near beautiful locations including forests, mountains, lakes and oceans. The location is ideal for a relaxing vacation, but the location also makes the home more susceptible to some natural disasters including forest fires, landslides and flooding. Because of this, you want to make sure your vacation home is insured whether occupied or unoccupied.
Because of the remote location of many vacation homes, they can be an easy target for theft and vandalism. No one is around to witness the destruction, so the thief can get away easier. Insurance on your vacation home can allow you to get reimbursed for any stolen items or damage to your property which might take place while you are away. Installing some sort of security system in your vacation home is a good idea, especially if you will be away for a long period of time. Although a security system will discourage some thieves, it will not deter all thieves from attempting to take your valuables. That is where good homeowners insurance protects you from large losses.
Many people who own a vacation home rent out the home when they are not using it. Whether letting friends use your home or letting strangers borrow it for a time, there is no guarantee that others will treat your home with as much care as you. Because of this, if you are allowing others to use your home, it is a good idea to make sure you have good insurance on it.
Protect your property. Call First Insurance Group at (800) 511-2892 for more information on Bardstown home insurance.


text:
Cryptos Rocket
Libra under Fire from US Politicians, But Bank of England Offers Hope
By cryptosrocket_bot 3 months ago
Mark Zuckerberg. Source: a video screenshot, Youtube, Guardian News
Regulators on both sides of the Atlantic are taking very different approaches to Facebook's Libra project – with American politicians hoping to strong-arm the social network and Libra partners, while British central bank officials have laid out a roadmap for the forthcoming token.
America's House Financial Services Committee has summoned Facebook CEO Mark Zuckerberg to a hearing on October 23, per a committee press release.
Arch crypto-skeptic Maxine Waters – who recently led a committee visit to meet regulators in Switzerland, where the Libra Association will be based – heads the committee and has previously called on Zuckerberg to halt work on Libra.
The committee says that the hearing, before the full committee, will be named "An Examination of Facebook and Its Impact on the Financial Services and Housing Sectors."
The press release also made mention of the so-called Keep Big Tech Out of Finance Act, a piece of draft legislation that would "prohibit large platform utilities, like Facebook, from becoming chartered, licensed or registered as a United States financial institution."
The committee added,
"The bill [would] also prohibit large platform utilities from establishing, maintaining, or operating a digital asset that is intended to be widely used as medium of exchange, unit of account or store of value."
And American lawmakers will not only target Facebook, but also its Libra partners. Two members of the Senate's own finance committee have written open letters to Stripe, Mastercard and Visa – all of whom are said to be wavering in their support for Libra.
Authored by Senators Sherrod Brown and Brian Schatz, the letters (which were shared online by Schatz) told Stripe, Mastercard and Visa, in what appeared to be a direct threat,
"If you take [Libra] on, you can expect a high level of scrutiny not only on Libra-related payment activities, but on all payment activities."
The senators even went as far as to allege that should the three companies continue supporting Facebook, they would be indirectly helping to fund "online child sexual abuse" and "fuel the growth in global criminal activity."
Brown is an outspoken Libra critic and during a Senate hearing in summer this year, the senator told Facebook's blockchain head David Marcus that the prospect of people "trusting Facebook with their hard-earned money" was "delusional."
Meanwhile, London has taken a different approach. In a Bank of England (BoE) release, authorities stated that even though "the terms of engagement for innovations such as Libra must be adopted in advance" of the token launch, they were prepared to work with Facebook.
The BoE stated,
"Libra has the potential to become a systemically important payment system."
The central bank did add provisos, however, stating that "activities conducted by other firms in the Libra ecosystem such as validators, exchanges or wallet providers" would need to prove their "stability" before Britain green-lights Libra.
The BoE advised UK regulatory authorities to "use their powers accordingly."
In August, Bank of England governor Mark Carney made a radical proposal for an overhaul of the global financial system that would eventually replace the dollar as a reserve currency with a Libra-like virtual one.
Tags: committee, facebook, libra
Previous Ethereum Surges 6% Leading Crypto Market Surge
Next Crypto Market And Bitcoin Primed For Gains: BNB, BCH, LTC, EOS Analysis
Top Technical Analysis
© 2019 Cryptos Rocket
$8,657.95 0.353%24H
$183.89 -0.61%24H
$0.267 0.370%24H
$275.45 0.0092%24H
Litecoin(LTC)
$59.99 1.90%24H
$21.12 0.715%24H
Cardano(ADA)


text:
« A Sad Story. | Just For Fun »
Bonderman Rocked; Streak Ended.
I can't help but feel culpable for tonight's loss to the Cincinnati Reds, 9-4, snapping a seven game winning streak. I spent the evening at a restaurant watching the Detroit Pistons force a game seven on Sunday against the Cleveland Cavaliers all the while text messaging my sister for updates on the Tigers since she could flip between back in Detroit. As I lamented the early deficit the Tigers found themselves in to my sister, she told me I had to choose between the Pistons winning a do-or-die game or allowing the Tigers to extend their streak to eight. I sacrificed the opener in the Interleague series to push the Cavs series to the hilt. Sorry everyone! The Pistons held on 84-82 and come back to Detroit for the series finale. I am a loyal fan of all the Detroit teams in all four major sports, with the Tigers and Lions pulling rank ahead of the Pistons and Red Wings, but tonight was the season for the Pistons so I had pull them through.
Back to the Tigers and sadly, the streak was bound to end. It is very nice to put these stretches together, but they cannot last forever. The Reds are considered Detroit's geographical rival for Interleague play and thus they are matched up frequently. In four season series since Interleague play began in 1997, the Tigers have split with the Reds at six games apiece while being outscored 57-53. This season's series is the first that actually holds any significance with each team out to the most surprising start in their respective leagues. Detroit, after today's loss, are tied for the best record in baseball at 27-14, while Cincinnati is two games back of the St. Louis Cardinals in the National League Central at 25-17.
Starter Jeremy Bonderman last just three innings allowing seven runs on six hits and three walks while striking out only three. Contrary to his career-trend, Bonderman has found himself in trouble during the middle innings while plowing through the first three with relative ease (as compared against his career numbers) in 2006. Tonight, he had a mix of his past with the present allowing two runs in the 2nd and six in the 4th. This season, pitches 46-60 have been Bonderman's tightest spot. Prior to tonight, he has allowed hitters a .313/.389/.375 line during those pitches and that was no doubt worsened as he lasted just 66 pitches against the Reds. The jams he was constantly putting himself in during those pitches finally caught up to him tonight. He had only allowed two runs despite that line while allowing 14 runs on pitches 1-45, but the Reds punished him for putting runners on this time around.
Placido Polanco's bat is coming alive of late with nine hits in the last six games as he teamed with Ivan Rodriguez and Magglio Ordonez to go 7-for-14, but it was not enough. Leadoff man Curtis Granderson was kept off base in five tries and Carlos Guillen and Brandon Inge were each saddled with 0-for-4 nights leaving on four base runners apiece. Marcus Thames rapped his 6th home run in 53 at-bats giving him one per 8.8 at-bats and one per 9.7 plate appearances. With Dmitri Young's hitting woes and now potential off-the-field problems, Thames could a pile of well deserved at-bats in the coming weeks. I'd rather see better circumstances under which Thames would get time, but it is a silver lining to the situation.
Roman Colon failed to offer substantial long relief in Bonderman's short outing as the team continues to search for that effective mop-up guy. Colon put on six in three and two-thirds allowing two runs and striking out three. It was only his second outing of the season, so he is likely to get a few more shots at being that guy, but tonight he was not able to squelch the fire started by Bonderman. He allowed 2.2 HR/9 last year in 69 1/3 innings between Atlanta and Detroit last year, and picked up where he left off tonight giving up Adam Dunn's 14th home run of the season.
Tomorrow, Mike Maroth (5-2, 2.18 ERA, 1.2 K:BB) is scheduled to face Eric Milton (2-1, 6.50 ERA, 2.6 K:BB) with first pitch set for 7:05 PM Eastern at Comerica Park. With a Pistons off-day, I'll have all my force behind a Tigers victory and on Sunday, I think the Pistons can pull through on their own, but I might have to split the love between the two.
DE-TROIT BASKET-BALL!
Posted on Friday: 05.19.2006 at 10:06 pm in Detroit Tigers	| RSS feed | Reply	| Trackback URL