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Nissan, which was crowned King of the Hill for both production and modified saloon cars at the 2017 Simola Hill Climb, has entered three category-defining vehicles for this year's competition.
First among the three is a first generation NISMO LEAF race car (RC), which will be piloted by Nissan product manager and test driver Janus Janse van Rensburg. This is the first time in South African history that an all-electric vehicle is entered in a Motorsport SA sanctioned event.
"The NISMO LEAF RC is truly special," says Janse van Rensburg. "It is powered by a completely standard 80 kW LEAF electric motor, but the entire drivetrain has been moved to the back of the vehicle and now powers the rear wheels."
Aside from the standard drivetrain, the LEAF is completely hand-built from aircraft-grade aluminium and carbon fibre. It features a roll cage, fully adjustable brakes and suspension as well as semi-slick racing tyres. It weighs 930 kg.
"Our team will work closely with MSA safety marshals and medics to train them on this new form of propulsion. While there is no risk of a petrol fire, charging the 390 Volt battery requires a unique set of safety precautions," says Janse van Rensburg.
The NISMO LEAF RC will be joined by the much renowned "Armageddon" Nissan GT-R of BB Motorsport. Armageddon will again be piloted by Wilhelm Baard, the reigning King of the Hill and the first person to break the 40 second barrier up the Simola Hill in a modified saloon car.
Since winning the 2017 Simola Hill Climb, BB Motorsport and Baard have refined the aerodynamics, handling characteristics and further improved engine performance.
"This year, Armageddon will have even more horsepower that can be called on if needed. It also has a more finely tuned aerodynamic and handling package," says Baard, who was nominated for the 2018 Pirelli SAGMJ Motorsportsman of the Year as the two-time Simola and reigning Nelspruit King of the Hill.
"The fact that there will be Nissan GT-Rs competing with anything from 700 horsepower to more than 1 500 horsepower is testimony to Nissan's engineering brilliance. It is no wonder that the Nissan GT-R is the most sought-after hill climb vehicle at Simola."
Last year, Baard broke the psychological 40s barrier for modified saloon cars when he set a winning time of 39.892 seconds up the 1.9 km track. This year, he believes that one of the front-running supercars will break 39 seconds.
"We are expecting very tough competition from other supercars, especially the other GT-Rs at the event. Aside from a new record up the hill, we believe that the competition will make for great spectating on Saturday and Sunday."
Edrich Zwiers will also compete in the NISMO BB Motorsport racing colours alongside Baard in a modified R35 Nissan GT-R.
"I race my GT-R on track, so it was not developed as a specialist hill climb vehicle, but I still believe I could break 40 seconds this year," says Zwiers, who has dramatically modified his R35 GT-R with the help of BB Motorsport and Nissan South Africa.
"Our GT-R has been fitted with semi-slick tyres, a straight-cut billet gearbox, front and rear racing differentials from Quaife and a new clutch basket that can handle 2 000 horsepower. BB Motorsport has also upgraded all the major engine components and the engine mapping, which will make this R35 GT-R a completely different beast to the model that gave us 7th place in the King of the Hill last year," says Zwiers.
While Zwiers and Baard will fight it out in the modified saloon car category, Reghard Roets will return to defend his title as the 2017 Saloon Car King of the Hill.
The Saloon Car category does not allow for any vehicle modifications, other than those that can be fitted by the manufacturer to a new vehicle. This means that Roets's R35 GT-R from Melrose Nissan will feature road-going tyres and 95 octane petrol.
Roets won the category last year with a final run of 44.540 seconds, beating fellow GT-R racer Jaki Scheckter by 1.415 seconds. It was his maiden entry in the competition.
"I really look forward to returning to Simola this year with the same GT-R as last year. While Baard and Zwiers have shown the breadth of the GT-Rs' capabilities, I believe that our R35 GT-R will show why the standard GT-R has become such an iconic supercar."
Nine Nissan GT-Rs have entered the 2018 Simola Hill Climb, including an R32 GT-R and an R34 GT-R.
Reghard Roets will compete in the Saloon Car King of the Hill Category – which he won in 2017
Tags: gtr, jaguar simola hillclimb, nissan, nissan GTR, nissan leaf, reghard roets, simola, simola hillclimb, wilhelm baard
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Do You Know The Buyer's "Should-Cost" Estimate?
Sellers who don't know, or fail to address the buyer's price expectations run the risk of chasing phantom opportunities where there simply is not the ability to pay (due to poor pre-qualification). They also risk being 'beaten-up on price', or being out-sold by a competitor.
Buyers rightly fear that answering such question sets the parameters for the seller's pricing. They are reluctant to share their 'should-cost' price expectation because they want to better it.
To download the full whitepaper in PDF format with tools to help grow sales, please visit The ASG Group website.
Ray Collis is a Business to Business sales coach, Director and Buyer Research Practice Lead of The ASG Group and co-author of the ground-breaking book, The B2B Sales Revolution.
Prev Post: Got A Severe Case Of Sales Disconnect?


The map below is for convenience in navigating your journey. Whether you are on St. Thomas or Tortola needing a land or water taxi, you've come to the right place. We make it easier than ever before to get to your destination relaxed and ready to enjoy your vacation. Once you've booked your flight and excursions, contact us for seamless transportation to and from each location. From St. Thomas to The Bitter End Yacht Club, we've got you covered.


Use Template IF/THEN Logic to include content in your Templates and Articles.
VALUE3 String: "My string" Number: '12.33' Date: "12/12/2012" Set Variable: var Subscriber Data: first Custom Data: age Article Name: "My Article"
It is very important to maintain the spacing around [VALUE1] [CONDITION] [VALUE2]. If those items are in a logic statement without being separated by a space, the logic will not function.


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Best all-around hip-hop & Sports Site in the game
Yungeen Ace Releases Music Video for "Ain't The Type"
Florida artist Yungeen Ace has released visuals for his newest track "Ain't The Type." In the video, Ace and his close friends turn a hotel kickback into a rendition of his favorite strip club with stacks galore, exotic dancers, security and even a classic brawl within the eventful night. The optics are directed by Julian Yuri. Yungeen Ace provides listeners with his hard-hitting lyrics, on a NJ Stepping Harder & CedDidit produced beat, in a hype and creative fashion.
"It's been a rough year for a lotta people, so I really wanted to make a lit track that could get people excited," said Ace. "I knew we had to get really creative with this video." "Ain't The Type" is out now on all streaming platforms, and the music video is out now on YouTube.

redpajama_set_name: RedPajamaCommonCrawl


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AMP scholarship lets singer follow her dream
Amelia Berry (Paul Henry)
Opera singer Amelia Berry's been awarded a $10,000 AMP Scholarship.
The scholarships are for Kiwis who "want to do their thing."
AMP is giving away 12 scholarships to lucky Kiwis like Amelia.
Amelia is a 27 year-old opera singer from Porirua.
After seeing something special in her Kapa haka performances, her high school teachers encouraged her into a music degree.
At University her tutors saw her potential and that's when she discovered her gift of singing Soprano.
Standing in front of her dream is the fiercely competitive audition season in New York.
Amelia's goal is to make her professional debut in the big international houses and sing on the stages of the world.
She fell in love with opera when she was a child after hearing recordings of Kiri Te Kanawa and was so inspired by the way she started out in NZ and ended up being an international star.
After finishing her music degree in Wellington, Amelia was accepted into the prestigious Manhattan School of Music in New York City, where she learned the discipline, self-motivation and strength she would need for a career in opera.
She made her debut with New Zealand Opera in a leading role at 24 years old and has since been asked back to sing each season.
Feel free to get in touch - send us an email paul@paulhenry.co.nz
The Paul Henry Show 6am - 9am Weekdays on TV3, Radio LIVE and www.paulhenry.co.nz
Other places you can find the Paul Henry Show:
Facebook https://www.facebook.com/PaulHenryShow/
Twitter https://twitter.com/PaulHenryShow
& Instagram https://instagram.com/paulhenryshow1/
Watch the video for the full segment.


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News Center Middle East & Africa
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Navigating your way to the Cloud
Microsoft partners with KidZania to Empower Children to be Future-Ready
October 29, 2018	 | Microsoft News Center
Kuwait City, 29 October 2018: KidZania Kuwait, the exciting kid-centric metropolis has joined hands with Microsoft Kuwait in a bold initiative to empower kids to achieve more through building their technology skills. The partnership with Microsoft is the first of its kind for KidZania and aims at equipping kids with digital and soft skills that would prepare them for the jobs of tomorrow.
The partnership was celebrated on 28 October, at a special ceremony held at KidZania in the presence of KidZania Kuwait's management team and Microsoft's official representatives in Kuwait. The collaboration is based on the shared vision of KidZania and Microsoft to inspire children by immersing them in real-life scenarios, that are both educational and entertaining.
Research reveals that by 2030 – and while automation replaces today's lower-skill jobs – the fastest-growing occupations will require higher-level of cognitive skills in areas such as collaboration, problem-solving, critical thinking, and creativity.
While KidZania continues its mission of helping children get ready for a better world, Microsoft will prepare them for their future workplace skills with the help of its solutions and innovations to build digital literacy. Microsoft has been at the forefront of digital transformation in the classroom by delivering new approaches to learning that can provide them with rich, immersive and collaborative experiences to develop critical and employability skills.
The Microsoft Innovation Lab at KidZania will offer a choice to experience three different activities that promote creativity, collaboration, computational thinking and problem-solving. The first is Hacking STEM which is a series of fun project-based activities that use everyday materials to visualize data across science, technology, engineering and math (STEM). The second activity is Make Code, a robotics activity that creates engaging computer science learning experiences that support a progression path into real-world coding. And the third activity is Paint 3D, that unleashes creativity and allows kids to bring 3D designs to life.
The Microsoft innovation lab is also equipped with the latest Microsoft Surface devices that are built from the ground up to boost engagement, productivity, collaboration and creativity, making learning interactive and inspiring.
Fernando Medroa, Vice President of Leisure and Entertainment at M.H. Alshaya Co., said: "Our collaboration with Microsoft underlines our strategic approach and contentious effort to empower kids by providing them with a fun-based learning opportunity to gain much needed skills to prepare them for the future."
Microsoft Kuwait General Manager, Charles Nahas, said: "Today's kids will go to work in a digitally transformed world – one in which the Fourth Industrial Revolution has forever reshaped how and where people earn a living. Microsoft has a proud history in education, having played an active role in transforming classrooms and encouraging entrepreneurship in students as well as empowering the youth to be future ready. The future digital communities will only create prosperity for all if we have the right leaders and workers – creative, critical thinkers grounded in soft skills and capable of great innovation. That is the work we have done; it is the work we are doing now; and it is the work that we will continue to do with partners like KidZania"
At KidZania, Microsoft will also focus on raising awareness of the essential role technology plays in children's lives, underlining how today's children are more comfortable with technology, and that being better equipped with the right skills will enable them to function more efficiently in the digital future. These efforts are in line with Microsoft's Cloud Society Future Ready initiative, that aims to empower the students of today to bring their ideas to life and build new worlds tomorrow, with the power of coding.
MCIT, Care Egypt Foundation and Microsoft collaborate on Women Empowerment across Egypt
Hub71 Launches Region's First Microsoft Reactor Program and Welcomes 17 New Startups Selected from 47 Countries
Microsoft appoints Kendi Ntwiga – Nderitu as Country Manager for Kenya
Microsoft teams up with Qatar's Aspire Zone Foundation, to accelerate digital transformation in the world of sports
"Microsoft Ignite The Tour" to empower regional IT pros with necessary upskilling


Optimum Life was born to truly inspire people to become healthy and happy, by using super clean supplements from organic ingredients combined with inspirational information on health and wellbeing. They approached George Creative to design a new brand identity predominantly to attract a health conscience, youthful, eastern suburbs based female audience.
The solution was a contemporary, vibrant and inspiring brand, that celebrated the energy and joy that comes with good health and living life to the fullest. The branding involved a logo mark, a variety of packaging designs and a website.


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Tag Archives: Walt Disney World
All Wheel Sports at Worlds of Fun
Worlds of Fun is bringing an all new show to the Heart of America Amphitheatre in June. 'All Wheel Sports," a finalist act on NBC's America's Got Talent," is a unique performance including BMX bikers, skaters, Pro Scooter riders and acrobats, who perform in gravity-defying, extreme sport spectacular. Described as, "…Cirque Du Soleil meets the X Games," by Howie Mandel, a judge on NBC's America's Got Talent, All Wheel Sports has performed for over 18 years at many major theme parks including Cedar Point, Knott's Berry Farm, Disney World, Universal Studios and now Worlds of Fun joins the list.
Star Wars Half Marathon Weekend Info
Runners can now register for the new Star Wars Half Marathon Weekend presented by Sierra Nevada Corporation at the Disneyland Resort. The intergalactic journey runs January 15-18, 2015. Runners can sign up at www.rundisney.com.
Jedi runners should move fast. Given the popularity of all runDisney race weekends, this transportive event will likely sell out at warp speed. In recent years, runDisney race weekends have regularly sold out in record time, and last year attracted more than 163,900 runners to Walt Disney World and Disneyland – a 40 percent increase over the previous year, making the runDisney series one of the largest in the nation.
Disneyland Resort Food Options
From fast-casual fare to haute cuisine, the menu of dining options at the Disneyland Resort offers something for every guest. Here, waffles with the Disney characters are as celebrated as the spectacular creations at Carthay Circle Restaurant and Lounge.
"We offer innovative cuisine from our award-winning chefs that match our guests' desire for elegant dining," said Gary Maggetti, director of food and beverage integration at the Disneyland Resort. "But you can still find the Disneyland classics, from the Café Orléans Monte Cristo to Plaza Inn's fried chicken."
Harambe Nights at Animal Kingdom
Harambe Nights at Disney's Animal Kingdom presents the sights, sounds and flavors of Africa during a dazzling new theatrical production and energetic street party celebrating the 20th anniversary of "The Lion King" classic film.
Each Saturday from June 7 through August 9 during this special-ticket, after-hours event, Harambe Nights treats guests to a magical evening. Venturing to the Africa section of the park, guests start the evening with a welcome reception featuring refreshing sips and savory bites of African-inspired appetizers. As they head to the Harambe Theatre, guests receive a special package of chef-created "Lion Chow" perfect for the 55-minute theatrical extravaganza, "The Lion King Concert in the Wild." This original show comprises celebrity narrators, a live orchestra, choir and special effects to present the moving story of Simba's coming of age like never before.
Seven Dwarfs Mine Train Opens!
Seven Dwarfs Mine Train, a playful and musical family-style coaster that immerses guests in the timeless story of Snow White and the Seven Dwarfs, officially opened at Magic Kingdom on May 28th, in time to greet summer guests to Walt Disney World Resort.
Joined by Big Brothers Big Sisters of Central Florida and Orlando Magic players Victor Oladipo and Tobias Harris, Magic Kingdom vice president Phil Holmes welcomed park guests as the first riders to experience the newest attraction at Walt Disney World Resort.


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History of the Christiania area
The agreement between Christiania and the state
State tasks
The negotiations between Christiania and the state
The buildings in Christiania
Contamination studies in Christiania
Christiania is a green and car-free neighborhood in Copenhagen with space to live in a different way within the general rules of legislation. Christiania is a unique area in Denmark which contains many different historical and cultural layers, and the entire area including the protected fortification and ramparts must serve as an open, recreational area for Christianites, the residents of Copenhagen and the rest of the population.
The Christiania area consists of the former Bådsmandsstræde Barracks and Christianshavn Ramparts which was established in the 17th century as a part of the fortress ring around Copenhagen. The rampart is a well-preserved military plant and is characterized as an ancient monument which is preserved to benefit future generations.
Christiania was established in 1971 and existed under special conditions for 40 years. After many years of uncertainty about the future organization of Christiania and after many negotiations between Christiania and the state, an agreement was entered on 22 June 2011 between the parties concerning the future ownership of the Christiania area.
The agreement meant that on 1 July 2012, a foundation, the foundation for the Freetown Christiania, was able to purchase the entire part of Christiania located outside the protected ramparts. The foundation leases buildings and land on the ramparts, which are still owned by the state. In this context, a number of specific purchase and lease agreements have been entered between the foundation for the Freetown Christiania and the Danish Building and Property Agency.
The residents in Christiania and others, who wish to contact the Danish Building and Property Agency concerning Christiania, can contact:
The Danish Building and Property Agency
Carsten Niebuhrs Gade 43, 1577 Copenhagen V
Tel. 0045 4170 1000


Leukemia is cancer of the white blood cells and their parent cells. The word cancer refers to diseases in which certain cells in the body become abnormal and the body produces too many of these cells.
What should I ask my healthcare provider about leukemia?
Hairy cell leukemia (HCL) is a rare form of cancer involving white blood cells called B lymphocytes. Learn more here.
When a parent has a serious illness, the children hurt too. Fortunately, a host of resources are available to help parents help their kids. Read more here.
Learn more here about childhood cancers and their treatments.
Clinical trials enable physicians and researchers to test patients' responses to promising new drugs and treatments. Find out if a participating in a clinical trial is right for you.


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July 17, 2013 kevinccole	2 Comments
He was valedictorian at his high school, because he is flawless. He is an improvisational comedian, and his brilliance has illuminated The Second City and the British and American incarnations of Whose Line Is It Anyway. Everything this man touches turns to gold. Though for most of our readers, he needs no introduction. This man is…
David Luna: What is your earliest memory?
Colin Mochrie: I was playing with a girl named Mary Brown in Scotland. I think she was my first crush. I was probably around 3. She never calls.
DL: Growing up, who or what made you laugh the most?
CM: My family wasn't very funny. They're Scottish, and their humor tends to be quite morbid. I guess my grandfather. He had a good sense of humor. He was a joke teller. He loved telling stories, so it would probably be him. But everyone else was pretty dark.
DL: As you might know, Alexander Graham Bell was another Canadian born in Scotland. Are there any non-comedian historical figures that you revere with great passion, a figure that might inspire you?
CM: I've often been fascinated with people like Columbus or Magellan, these people who head out not knowing exactly where to, with some vague sort of goal in mind, but ending up somewhere totally different, sailing a world that they think is flat and could fall off the edge. It's almost like improvising, except we're never in any kind of mortal danger.
DL: Do you have a thirst for adventure, or are you a bit more sessile?
CM: I enjoy adventure in the grand sense of the word (going out, doing something I've never done before, going places I've never been). But, you know, climbing mountains or jumping out of planes, ehhh, no, not really.
DL: Will there be anything new that we might not expect with the return of Whose Line Is It Anyway?
CM: I don't really know much about it except Ryan, Wayne, and I are doing it for sure, an improviser named Heather Campbell is doing it, and Aisha Tyler is hosting. So it's nice that there's actually women involved this time, so it will take some of the pressure off me.
DL: Did you ever have any say in who was invited as a guest on the show?
CM: We can make suggestions, but it's really up to the producer, who's a real control freak, so it's up to him. We've talked up certain improvisers, but aside from that the special guests were always a total surprise. You never expect, within shows of each other, Sid Ceasar, Lassie and Richard Simmons. It's all over the place.
DL: Are there any memories from doing that show that stand out from the rest?
CM: I don't remember specific scenes—well, I remember the Richard Simmons scene only because it was the longest laugh that I think we ever got on the show. Actually, when you see the show they cut some of the audience reaction because it was kind of overboard. It was going way too long. But aside from that, aside from a general feeling of happiness about working with the guys, it was pretty quick and dirty. It was three weekends out of the year.
We'd go down there, we'd shoot Friday, Saturday, Sunday, then take a couple of weeks off, come back and do that again, so it was all kind of a blur. There are times I'll be switching channels and see Whose Line is on, and I know that I did the scene because I'm watching me do it, but there's no recollection of it whatsoever.
DL: By doing it all in one weekend, would you say that was better for the energy, instead of having it dragged out over a period of say a couple months?
CM: I think so. It kept us warmed up, doing it in short bunches like that. Usually when you're doing a series you rehearse for the week and then you shoot on a Friday night, and then you start all over again. We managed to get three days of playing 22 games a day, so we were on a real buzz.
DL: In improv, have there been train wrecks or cringe worthy moments that you've witnessed or gone through that stand out in your memory?
CM: Absolutely, but the beauty with improv is it's gone. Once you do it you're onto the next thing because your mind is going 100 miles and hour just trying to keep things going. There are whole shows, and they're usually corporate shows where we're brought in to do the entertainment for an awards night or something. They usually tend to be horrible. It's not in a theatre, it's usually some banquet hall, there's always issues with the mic, people really aren't interested, and they just want to either get an award or get really drunk. So you just kind of go into survival mode and try to protect yourself by mentally blocking it out.
DL: Have there ever been any surreal groups of people you've had to perform for, like a corporate show for some kind of czar or something?
CM: Brad Sherwood and I have been touring for the last ten years, and we did five shows in India. We were brought over by this liquor company, and the owner was this billionaire who was at every show. He sat in the front row, and every once in a while a guy would come out with a tray with one glass of wine on it. He'd have a sip, put it back on the tray, and then the guy would go back and get a fresh wine. So that was pretty bizarre.
DL: To be involved in a web series like "Patience Please," you must be sick in the head in all the right ways. Has your sense of humor ever gotten you into trouble, or at least put you in a tense or awkward situation?
CM: Usually my humor gets me out of trouble. It's gotten me out of fights and weird situations. So far it's worked on the good side of the force.
DL: In other interviews you've mentioned that you were interested in the sciences, marine biology, specifically. If you had your own nature show, something not unlike the programs of David Attenborough or Jeff Corwin, what places and animals would you most like to visit and see?
CM: My wife and I went to the Congo a couple years back. There's this reserve where they have bonobos, and they have 99.7 percent of our DNA, and all they do is make love all day. I guess that's the part of the DNA we're missing. So they're just these loving monkeys who enjoy each other and never fight. So I found that fascinating, that there are actual beings like that living on this planet.
DL: Now, where did your reverence for nature come from?
CM: I have no idea. My people are not nature people. It's not like we ever went camping or anything. I enjoy the outdoors. When I wanted to be a marine biologist, under the sea always fascinated me. I just loved, and I still love, going under water and just having that peace. Even though it's teaming with life, there's a peace and quiet that you don't get on the surface.
DL: What has been your greatest struggle working as an actor and comic?
CM: I guess getting hired. In this business, people love to put you in a certain category. So because we start off making our name in improv, which has been great, it also has some setbacks in that people think, "Well, they can't do a script, or if they do a script they'll just go completely off it and screw around with it," which isn't true. Everyone who was on Whose Line has acted before. Chip Esten is one of the leads in Nashville and is doing a great job; he's amazing in it. So it's always been frustrating that we never have a chance to be able to do other things. You know, here and there if they need a whacky neighbor or something we get the call. And certainly I have no burning desire to do Hamlet or super serious parts, but I would like to do stuff that's different. That's sort of the frustration, is getting casting people or directors to see you in a different light.
DL: I'd certainly enjoy watching you as a villain on a show like Dexter.
CM: I'm at the age now where friends are starting to get into positions of power and can hire me. A friend hired me to play this villain for this season of a Buffy kind of show, where I was the evil demon villain for the year. So I got to kill people with shovels and things I never get to do. It's called Dark Rising.
DL: The original run of the American Whose Line was on ABC. Being that it's Disney's network, did you ever feel limited in certain things you could say publically, or do, or be involved with?
CM: I never thought that, and I never got that feeling from the network or from Disney. There's some stuff we did on the show that I still can't believe we did on a Disney-owned network. Having it worked out so it looked like Richard Simmons was fellating me, I don't know how many networks you could actually get that on now. So we kind of lucked out with them. They sort of kept their distance, which on the one hand was great, but on the other hand they didn't really know what the show was (I think that's part of the reason they kept their distance).
DL: If you could shapeshift into any animal, what would you choose to be and why?
CM: Well, the bonobos have it pretty good, eating and having sex all the time. A dolphin. I'd like to—hmmm. Well, you see, I'm torn. I'm going between sky, land and ocean. I would love to be like a hawk or something and just have that freedom of flight. I think I'll have to go with dolphin.
DL: Dolphin, yeah. They also like to have sex all the time I think, right?
CM: Well that's the thing, and they look cool, they're smart, they can swim really fast, and sometimes they get a television series.
DL: If you could choose your death, how would you go?
CM: It would be after a perfect day. So there would be three fantastic meals at three of my favorite restaurants, I'd be spending time with my wife and son, and some wild sex, and then dying at the height of my REM, around, I don't know, 2:30 in the morning.
DL: After you die, what do you want to be remembered for, or what do you hope to leave behind?
CM: Ah, well, obviously a lot of broken hearts. I don't know. I hope that people can take from my career that things happen when you least expect it, and you can do anything. When I was growing up this was not an occupation, and yet here I am making a living making up crap. So, the possibilities are endless. Just believe in yourself and go forward.
Colin Mochrie will be in The CW's revival of Whose Line Is It Anyway. You can visit his official site, www.colinmochrie.com or follow him on twitter @colinmochrie.
Colin Mochrie Portrait by Buddy Purucker
Our Interview with Colin Mochrie was published in The Annual #4 and can be purchased for $3 by using the code "WHOSELINE" this week!
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Research Papers Online - research paper on language teaching | supporting your academic career with over 100,000 essays, book reports, thesis, and term papers.
In ten pages this paper discusses foreign language teaching and the application of technology in the US and elsewhere. Twenty one sources are cited in the bibliography.


The soothing greens colours of calm, palms bathing in light and shade, drawn by the hypnotic water, a peaceful mind, resting. I could return here again and again.
Artists original medium format film photograph is worked on in layers using textures, paint and stencils overlaid in post production to create the final work. Hand printed limited edition print signed and numbered by the artist. Canson Baryta fine art museum 310 gsm satin paper, printed using archival pigmented inks. Includes the certificate of authenticity and care instructions If you would like a different size, or have the print mounted under Plexiglass or on Aluminium Dibond please let me know and I will create a custom listing for you.


While many supplements promise to build up your body and enhance physical ability and appearance, Focus Factor concentrates on your brain. This supplement contains a blend of 40 ingredients, which its manufacturer claims can improve your mental ability and enhance memory. While some of the ingredients in Focus Factor offer benefits, you should research them thoroughly to understand how they work. In addition, you should consult a doctor before taking any supplements, as they may be ineffective or even harmful.
Choline is a molecule that, according to the website World's Healthiest Foods, is involved with nervous system communication and the function of your cell membranes. Choline is found in egg yolks, peanuts, cauliflower and oats, among other foods. While choline does effect the nervous system, the University of California at Berkeley notes that "there is no evidence that consuming extra choline will do anything for memory."
Vinpocetine is an extract from the periwinkle plant that my have beneficial effects for your nervous system. According to research from the journal Neurochemistry International, vinpocetine displayes neuroprotective characteristics, especially in terms of preventing against damage from excess glutamate. This research also noted that combining vinpocetine with other substances has more significant effects than vinpocetine alone. There is no guarantee the vinpocetine in Focus Factor will protect you from neural damage.
DMAE, which is an abbreviation for dimethylethanolamine, is a compound sometimes used to treat depression. As the University of California at Berkeley notes, DMAE helps your body produce choline and has a long list of purported benefits, from increasing intelligence to reducing wrinkles. The university notes, however, that it's "very unlikely that DMAE can do any of this."
L-glutamine is an amino acid that is associated with muscle recovery, but it can also have benefits for your brain. Research from the Journal of Nutrition indicates that glutamine is transported to neurons, where it is converted to glutamate, which is necessary for neurotransmission, which is how your brain communicates with your body. Glutamine is included in Focus Factor to provide more glutamate for neurotransmissions, but there is no guarantee of its efficacy.
DHA, or Docosahexaenoic acid, is an Omega 3 fatty acid that can be found in fish such as salmon. According to research from the journal, Neurobiology of Aging, DHA may be helpful in slowing the decline of cognitive abilities associated with aging. This research suggests that DHA can help reduce the rate of memory decline, though it was not effective for slowing reductions in cognitive abilities of older individuals.
Is MSG Bad for Pregnant Women?


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Holding Don Giovanni Accountable
By Kristi Brown-Montesano
"Now am I allowed to say rapist." — Rose McGowan tweet, 10 Oct. 2017
"No one took Rose McGowan's claims seriously. Now everyone is listening. "— Headline in the Los Angeles Times, 13 Oct. 2017
At the end of summer 2016, just before the fall semester started, I received a commission from the Bilbao Opera to write a program note on the women of Don Giovanni. The requested subject was not a surprise. I finished my dissertation on the female characters of Don Giovanni and Die Zauberflöte in 1997; ten years later, in 2007, my book came out, expanding the coverage to Le nozze di Figaro and Così fan tutte. While I subsequently stepped away from Mozart studies, I have never tired of coming back to these characters who still have a lot to say to us.
My editor at Bilbao, Willem de Waal, took a rather gutsy stance: he encouraged me to illuminate readers about ethical criticism and to address seriously the elements of sexual assault and coercion that are central to the Don Juan stories and Don Giovanni in particular. Contemporary relevance was obvious. Willem mentioned the recent arrest of Spanish porn-film producer "Torbe" who was charged with selling child pornography, abusing female minors, and sex trafficking; there were separate accusations of forcing girls to have sex with famous footballers. Here in the US, Bill Cosby has been ordered to stand trial, charged with three felony counts of aggravated indecent assault against women. A mistrial followed when the jury deadlocked. A few weeks after I submitted my piece to Bilbao, the Access Hollywood tapes of Donald Trump surfaced: "You know, I'm automatically attracted to beautiful — I just start kissing them. It's like a magnet. Just kiss. I don't even wait. And when you're a star, they let you do it. You can do anything. This girl—beautiful, young, flirty—I met her on the street; I came up to her, took her hand; she tried to escape…"
(A parte: Oh, wait: that last bit was the Don, not The Donald.)<1>
Let me backtrack. About 25 years ago, I read The Operas of Mozart (Oxford, 1977) by William Mann, one-time principal music critic of The Times of London. The book had been listed on the Metropolitan Opera's recommended reading for Don Giovanni in 1991, the bicentennial of Mozart's death and the same year I decided to do a dissertation on Mozart opera. Covering the complete stage works, Mann offers historical background and lightly analytical descriptions of the musical numbers, all seemingly aimed—much like Mozart's music—to engage both the opera connoisseur and newbie amateur. His prose is eloquent, his humor mostly English, clever and dry. But in the middle of his discussion of Don Giovanni, Mann suddenly goes into the red zone, excoriating Donna Anna, the first woman character we meet in the opera and the only one who consistently denounces Don Giovanni:
Anna is an upper-class Spanish lady who has etiquette where her feelings and brains should reside. Duty and honour are her watchword. Towards all her fellow-creatures she presents a coldly correct personality. If she loves her father it is because the Bible told her so. Her censorious anger against others is a juvenile trait. All men, to her, are beasts, and it would be beneficial to her personal growing-up if she had been pleasantly raped by Don Juan.
Pleasantly raped by Don Juan. I have never forgotten these words or stopped objecting to what they represent: deceptive and toxic misogyny masked as authoritative criticism. Mann's oxymoronic formula relies on one of the oldest and most pernicious excuses for rape: she really wanted/needed it. And while his wording might be the most egregious, Mann's basic position is widely echoed in the critical reception of Don Giovanni, which skews heavily in favor of the libertine aristocrat, recalling what Sunday Times book critic Raymond Mortimer wrote about James Bond in 1963: What every man would like to be, and what every woman would like between her sheets<2> . Commentators and directors have idealized Mozart's willful, seductive, and violent protagonist, crediting him with virtues (unflagging bravery, triumphant self-determination, revolutionary resistance to oppressive societal power, and sensual idealism) that are, at best, only equivocally suggested in the original libretto.
The female characters, in turn, are judged largely in terms of charm and receptiveness to the Don's don't-say-no sexual advances. Resistance to him is understood as a flaw—or a lie. In the words of Kierkegaard's fictional Mr. A, "a foolish girl it would be who would not choose to be unhappy for the sake of having once been happy with Don Juan." Fast forward 170 years later and you find conductor James Conlon rhapsodizing that all three female characters have experienced a sexual metamorphosis, compliments of Don Giovanni: "their erotic impulses awakened, magnified and irrevocably changed by their encounter with this mythical seducer."<3>
Yes, Don Giovanni comes from a different time. But this is a poor excuse for partitioning opera/art from contemporary ethical values, forever justifying behavior that—in any age—is predatory and exploitive. Does the work benefit from this protection? Do we?
The original libretto repeatedly points to abuse of power and sexual trespass, beginning with this exchange between master and servant:
Bravo! Two pretty deeds!
Force the daughter, then murdered the father!
He asked for it: his own fault.
And Donna Anna, what did she ask for?
Shut up, and stop annoying me. Come with me,
unless you're asking for something, too.
Leporello tellingly uses the word sforzare to characterize Don Giovanni's treatment of Donna Anna, corroborating the young woman's own statement: "He came up on me silently and tried to embrace me; I tried to break free, he held on even more tightly; I screamed; no one came. He held a hand over my mouth to silence me, and gripped me so tightly with the other hand, I thought I was beaten." Two other incidences of what we would categorize as sexual assault make Donna Anna's testimony more compelling: Zerlina shrieking for help at Don Giovanni's ball after he drags her to an antechamber, and the libertine's own account of physical intimacy with a woman using false pretenses (she mistakes him for her boyfriend, Leporello). The woman starts yelling when she recognizes her mistake, and the nobleman has to escape over a wall.
Erotic impulses awakened, my ass.
This season, like all seasons, Don Giovanni is being staged in cities all over the world—cities in which dead-serious conversations about sexual assault are also taking place. Here in the US, the bravura rage arias sung by Rose McGowan and other victims who would not be silenced finally unmasked the scellerato Harvey Weinstein. Like Donna Anna, the original "assalitrice d'assalita," McGowan is outspoken and resolute. If she doesn't conform to public expectations of a victim, this should not make her accusation less forceful, her willingness to go public less courageous, her pain less profound. We should know better.<4>
So what do we do with Don Giovanni now that the work's headliner brand of masculinity is finally facing the heat of full-coverage public denunciation in the real world? We could chuck the whole thing, of course, but I'd like to think there are more creative ways to deal with the challenge of canonic opera's pervasive misogyny. As a staged art form, opera offers a unique opportunity to engage thoughtfully with the racial, class, and sexual politics that old operas dramatize for new audiences. Along these lines, Adrienne Rich offers a pointedly feminist perspective, addressed to women for the deliverance of women:
"Re-vision—the act of looking back, of seeing with fresh eyes, of entering an old text from a new critical direction—is for [women] more than a chapter in cultural history: it is an act of survival. Until we can understand the assumptions in which we are drenched we cannot know ourselves. And this drive to self-knowledge, for woman, is more than a search for identity: it is part of her refusal of the self-destructiveness of male-dominated society."
"Let us rescue the innocent!" exclaim Donna Anna, Donna Elvira, and Don Ottavio at the end of Act 1, rushing to defend the honor of a common girl, a country bumpkin, a "no one" in their class-conscious world. Soon the whole crowd will confront il dissoluto revealed. No one buys his cover story, the attempt to shift the blame to Leporello. Aristocrats and peasants alike join in condemnation: "Tremble, scoundrel, the whole world will know of your black, horrendous misdeeds, of your cruel arrogance."
This is the moment that the women of Don Giovanni have been waiting for: the seducer-predator unmasked, judged, and found guilty. Too bad the work couldn't just end with this scene, the three sopranos united in musical line and dramatic purpose. (How often does that happen in canonic opera?) Instead, tradition dictates that Don Giovanni meet his match in the form of a supernatural patriarch, complete with hellfire and terrific scoring.
In real-life sexual assault cases, of course, there are no vindicating Stone Guests—just a rocky judicial process that stirs to life only when victims are brave enough to tell their story and take the stand. Likewise there are no "mythical seducers" who "pleasantly rape," only men who won't take no for an answer<5> . Powerful, educated, creative men like Matt Lauer, John Lasseter, Mark Halperin, Charlie Rose. Like Don Giovanni.
Many of the acclaimed men who are now facing serious consequences for sexual harassment and assault have long operated in a culture that preferred to look the other way, not least because corporate employers and board members saw these men as too big to fail. Their brand was more important than the rights of alleged victims. The classical music world is no less implicated in this gentleman's agreement. There have long been rumors and "open secrets" around conductors and applied teachers, who are often gatekeepers to major career opportunities. And few such secrets have been more open than those around James Levine, operating at the very heart of opera culture in this country. The self-interested and institutional protections around these men are finally--finally--toppling under the broad societal pressure for serious investigation.
Don Giovanni falls into a parallel category: an art product whose aesthetic value and guaranteed box-office receipts have deflected critical charges against the main character. My program note for Bilbao drew a hard line: the only way to make Don Giovanni worthy of our time, if indeed that is possible at all, is to listen more closely to the women. And if we really care about opera's continued relevance, then everyone who loves the art form—directors, conductors, singers, critics, educators, audiences—must acknowledge the connection between what we applaud on stage and what we permit in the workplace, school, home. Because Donna Elvira could tell you, the "Catalogue Aria" is not so funny when your name, or the name of someone you love, is on the list.
<1>On 28 November 2017, the New York Times reported that Donald Trump is now denying the authenticity of these tapes, allegedly suggesting that the voice in the tape was not his. https://www.nytimes.com/2017/11/28/us/politics/trump-access-hollywood-tape.html
<2>Often misattributed to Raymond Chandler. http://jamesbondmemes.blogspot.com/2012/07/what-raymond-chandler-didnt-say.html
<3>https://www.laopera.org/news/blog/Dates/2012/9/Don-Giovanni-the-Unknowable/
<4>And yet this just in: the presiding judge in the recent "wolf pack" rape trial in Spain decided to allow evidence about the alleged victim's personal life and character into court, but barred the prosecutor from presenting texted conversations between the accused which apparently made plans to rape women.
<5>http://video.newyorker.com/watch/harvey-weinstein-caught-on-tape
Chair of the music-history faculty at the Colburn Conservatory of Music in Los Angeles, Kristi Brown-Montesano received her Ph.D. in musicology from UC Berkeley, combining her strong interest in both musical performance and scholarly research.
Her book The Women of Mozart's Operas (University of California Press, 2007) offers a detailed study of the female characters in the Da Ponte operas and The Magic Flute. Dr. Brown-Montesano has presented and published essays on music in contemporary film, opera, trends in marketing classical music, and musical culture in late 19th-century England.
In 2014-15, she was honored to participate in the UCLA Musicology Department's Distinguished Lecture Series. An active "public musicologist," she has been engaged by numerous organizations in Los Angeles, including the LA Opera ("Opera for Educators"), the Opera League of Los Angeles, the Mason House Concerts, and the Colburn Orchestra. She is especially thrilled to join the LA Phil's "Upbeat Live" faculty this concert season.
peterb December 5, 2017 at 1:44 PM
Thank you for this thoughtful take. Operas (and sometimes, sadly, those who enjoy them) are often steeped in sexist or racist traditions, and the Mozart/Da Ponte operas in particular have always been hard for me to take. The only productions of them I've really managed to enjoy in terms of narrative are those that take the bull by the horns and grapple with the problematic aspects of the texts head on.
Sadly, few do this, and many even go in the wrong direction, dripping down the terrible "Maybe Donna Anna was asking for it" drain. That sort of interpretation is horrifying for me to watch as a man; as a woman I can only imagine it would be unbearable.
Thank you for this piece. It is worth noting that two or three seasons ago, Martha Nussbaum's program essay for the Lyric Opera of Chicago production of Don Giovanni argued that Anna, Elvira, and Zerlina were the true protagonists of the opera. And Peter Sellars' production of Le Nozze di Figaro from the 1980s, which set Le Nozze di Figaro in - of all places - the Trump Tower, seems astonishingly prescient in hindsight.
hleighh December 6, 2017 at 11:46 AM
As far as I can tell, the "Donna Anna needed to be ravished by Don Juan in order to be awakened to her full existence and potential" line of interpretation descends from E.T.A. Hoffmann's 1813 short story "Don Juan, or, An Episode in the Life of a Traveling Music-Enthusiast."
Bryan Townsend December 8, 2017 at 11:34 AM
It seems worth while to point out that Don Giovanni does receive a suitable punishment: he is condemned to hell.
Concerned Guest March 20, 2018 at 10:44 PM
Hi Bryan, what does any of this have to do with sexual assault in the 21st century? She mentions that there are no "vindicating Stone Guests" in real life assault cases. One of the main points of this essay is that we can't relate Giovanni to modern sexual assault because it is laden with canonical misogyny and flaw. Have a lovely evening.
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Rightster, the online video distribution and marketing specialist, has signed a global video content distribution deal with international media group and digital publisher Future to help increase audience reach and revenue streams for their technology and gaming publications.
Rightster will increase exposure for Future's video clips from their technology and gaming publications by creating a private syndication portal (PSP) that will distribute and monetise Future's digital video portfolio to their publisher partners. The clips will include how-to videos, gadget reviews, conferences, and product reviews. These clips will be unbranded to have universal appeal, simplifying the syndication process. Rightster's media sales team will provide advertising solutions for this content to drive revenue growth.


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Netrebko
Beethoven: Emperor Concerto
La gazzetta
Ugo Guagliardo
Odoardo e Cristina
Iosef Ivanovici
SPONSORED: DVD Spotlight. Olympic Scale - Charles Gounod's Roméo et Juliette, reviewed by Robert Anderson.
SPONSORED: Ensemble. A view from the pit - John Joubert's Jane Eyre, praised by Alice McVeigh.
Nicola Benedetti
The young Scottish violinist Nicola Benedetti was born in West Kilbride on 1 July 1987 to a Scottish mother and an Italian father. She studied with Natasha Boyarskaya at the Yehudi Menuhin School, with Maciej Rakowski in London and Pavel Vernikov in Vienna.
She won the 2004 BBC Young Musician of the Year competition with Szymanowski's Violin Concerto No 1, and signed a recording contract with DG / Universal in the same year. She has recorded newly commissioned works by James MacMillan and John Tavener, has explored authentic baroque performance and has worked with Wynton Marsalis on jazz-influenced repertoire. She has played with most major orchestras in the UK and Ireland, and is performing increasingly in Asia, mainland Europe and North America.
A selection of articles about Nicola Benedetti
Ensemble. Hugely Enjoyable - Bernstein, Marsalis and Musorgsky from Nicola Benedetti, Cristian Măcelaru and the Hallé Orchestra, reviewed by Mike Wheeler
Ensemble. Sheer Naked Energy - Mike Wheeler is impressed by Mendelssohn and Beethoven from Nicola Benedetti, Tom Service, Nicholas Collon and Aurora Orchestra
Ensemble. Bringing Together - Roderic Dunnett visits James MacMillan's Cumnock Tryst
Ask Alice - On Nicola Benedetti, losing the 'Max' in Max Bruch and the National Children's Orchestra of Great Britain, with Classical Music agony aunt Alice McVeigh
Ensemble. Full of Delights - Nicola Benedetti and the European Union Chamber Orchestra, heard by Mike Wheeler
CD Spotlight. Marvelously Incisive - Rózsa and Korngold violin concertos, recommended by Howard Smith. '... breathtaking virtuosity from soloist and orchestra alike.'
Ensemble. Tremendous Energy - Mahler and Mozart in Nottingham, reviewed by Mike Wheeler
Ensemble. Which Concerto? - A concert by the European Union Chamber Orchestra, reviewed by Mike Wheeler


Who approves training programs in Delaware?
The Division of Long Term Care Residents Protection is responsible for the training and testing program for nursing assistants as well as for the Delaware CNA Registry. Those who want to become certified nurse aides in Delaware must enroll in a CNA training program that is approved by the Division of Long Term Care Residents Protection. Individuals interested in providing a new nurse aide training program should also contact the Division to request an application and find out the applicable state and federal requirements.
Who approves the CNA training programs in California?
Who provides state approved nursing assistant training programs in Idaho?
What are the certification renewal requirements in Delaware?
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About Roland Clark
Dr Roland Clark is a Senior Lecturer in Modern European History at the University of Liverpool, a Senior Fellow with the Centre for Analysis of the Radical Right, and the Principal Investigator of an AHRC-funded project on European Fascist Movements. He is also the current President of the Society of Romanian Studies. Clark has written Holy Legionary Youth: Fascist Activism in Interwar Romania (Cornell University Press, 2015), Sectarianism and Renewal in 1920s Romania: The Limits of Orthodoxy and Nation-Building (Bloomsbury, 2021), and numerous journal articles and book chapters. His interests include fascism, lived religion, the Holocaust, gender, and student movements.
Roland Clark is a Senior Lecturer in Modern European History at the University of Liverpool, a Senior Fellow with the Centre for Analysis of the Radical Right, and the Principal Investigator of an AHRC-funded project on European Fascist Movements.
Roland's website
NBN Episodes hosted by Roland:
Eastern European Studies December 1, 2021
The Secret Police and the Religious Underground in Communist and Post-Communist Eastern Europe
James A. Kapalo and Kinga Povedák
Hosted by Roland Clark
This new book by James Kapaló and Kinga Povedák explores the complex intersection of secret police operations and the formation of the religious underground in communist-era Eastern Europe. In sixteen …
Eastern European Studies November 26, 2021
Romania's Holy War
Soldiers, Motivation, and the Holocaust
Grant T. Harward
What motivated conscripted soldiers to fight in the Romanian Army during the Second World War? Why did they obey orders, take risks, and sometimes deliberately sacrifice their lives for the …


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Best Personal Finance Influencers You Should Follow in 2021
We all have learned a few tips and tricks from our parents to manage our money, haven't we? In addition, most of us have taken advice and inspiration from people who've touched our lives. In a world filled with social media content, where we continue to observe and learn from people on our feeds, why not learn more about personal finance?
Finance experts, bloggers, Instagram, and Twitter influencers share their expertise freely and abundantly. Their voices are heard by millions of people and have helped in changing many lives as well. Take Shark Tank, for example; the show and investors helped save and grow businesses and made many of us rethink the way we spend our money.
If you want to get expert advice on a range of topics related to money, here are some of the best personal finance voices to be heard and followed in your path of financial wellness.
a) Anthony O'Neal
At the age of 19, Anthony O'Neal became homeless, was in a debt of $35,000 due to college tuition, and had a lifestyle dependent on loans and credit cards. Years later, he managed to eliminate that debt, save money and turn his life around. He has authored several books like "Debt-Free Degree" and "The Graduate Survival Guide." He is active on Instagram and Twitter, where he talks about life, financial advice, and stories of other people who have become debt-free.
b) Sucheta Dalal
She is the ex-financial editor of Times of India who co-founded Moneylife Foundation. Sucheta Dalal's nonprofit organization works towards improving the financial literacy of India. In 2006, she was awarded Padma Shri for journalism. The author of "Putting Savers First" is passionate about tweeting on personal finance.
c) Humphrey Lang
Famous for counting 10,000 individual rice grains to illustrate Jeff Bezo's wealth, Humphrey Lang shows extreme dedication to help his audience visualize and understand complex financial topics. Yang uploads personal finance videos regularly on his YouTube channel.
d) The Budgetnista
Tiffany Aliche started her career as a preschool teacher who is a financial educator and author today. Tiffany serves financial education in tidbits of information filled with personality and humor on her blog and social media channels. Follow her for budget hacks, tips for buying a home, practical challenges to reflect on your financial wellbeing, and more.
e) Neil Patel
The New York Times bestselling author Neil Patel writes about entrepreneurship. His blogs offer realistic advice on how to build a business. Patel has offered business insights to tech giants like Amazon and Viacom. The Wall Street Journal has regarded him as a top web influencer, and the United Nations has also given him a nod as a top 100 entrepreneur under the age of 35.
f) Emma Edwards
If you wish to have heart-to-heart financial conversations, follow Emma Edwards. She is a self-proclaimed "recovering spendaholic" who changed her financial life at the age of 26. Through thoughtful and informed spending, she helps her Facebook and Instagram followers gain the same mindset. Emma's social media feed includes educational content with excellent pep talks, which will surely make you feel empowered.
g) Safal Niveshak
'Safal Niveshak' is a Hindi phrase that means 'successful investor.' Blogger Vishal Khandelwal stresses the importance of investing regardless of your age or salary. He believes that good investment can lead to a stress-free life. Through Safal Niveshak, Vishal guides his audience with tips on financial planning and managing money smartly.
h) Zero-Based Budget
Cindy Zuniga was $215,000 in debt because of her student loan for getting a law degree. After she graduated, Cindy decided to control her finances and paid off her debt in 48 months! During those months, she posted her journey on Instagram and still uses that platform to share her hard-earned personal finance tricks and her life as a lawyer and budget coach.
i) Mr. Money Mustache
Peter Adeney, a.k.a Mr. Money Mustache, retired at the age of 30. He is famous for his blog, which is much appreciated by his community called the Mustachians. Peter advises on everything ranging from investments to fitness without a gym membership and transporting large appliances via his bicycles. Through his social media accounts, he shares the merits of biking and financial independence.
j) Sonia Shenoy
Sonia Shenoy conducts fundamental research in various sectors like real estate, automobiles, and aviation. She is the deputy director at CNBC TV18 and is a popular news anchor. Sonia shares tech reviews, income, and stock tips on her Twitter and Instagram, along with updates on her life.
For more insights and advice on financial management, investments and loans, visit EarlySalary. We hope that the influencers mentioned earlier will help you on your financial journey. Since financial podcasts are pretty famous, too, you can check out our blog about them.
Connect with us on Facebook, Twitter, Instagram, and Linkedin to talk about finance. Download our app or log in to our website to avail of instant loans! Be a part of the #OneSmallStep experience.


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Dustin Bailey
John Romero politely states the obvious about the new Commander Keen
There's a new Commander Keen coming, but it's not much like the old Commander Keen. The new one is a mobile game focused on having you blast aliens with goofy gadgets, and – look. There are loads of truly excellent mobile games out there, and Bethesda has successfully expanded on existing series with games like Fallout Shelter in the past. But Commander Keen has been gone so long, this revival is tougher to accept.
But Commander Keen on mobile is probably not made for us, as id co-founder John Romero diplomatically tells Game Informer. "When I saw the game video, I was like 'well that's not a platformer the way that Keen was a platformer.' My thought was that the designer behind it must not be making this Keen for the people who played Keen originally," Romero says.
"I think they want to take it in a different direction, and it seemed to me that it was an experimental gameplay kind of thing. Because I haven't played a game like it. Maybe this is like 'let's introduce this IP and do something interesting and new with it, for an audience that is not the people that used to play Keen, but that play a bunch of mobile games.'"
He says "I don't play stuff like this, but maybe there is already an audience that does that. And maybe this will catch fire because it hits all those people who do play stuff like that."
Romero did say he enjoyed the cartoon in the trailer, so there's that, at least.
Read more: Check out the best old games on PC
Right now, Romero is working on a mobster-themed strategy game called Empire of Sin. For more on all the E3 2019 games – but mostly the ones releasing on PC – check back with us throughout the week.
Best free PC games
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Green Candidate Elms Runs Unopposed for South Glens Falls Village Board
South Glens Falls, NY — The Green Party's Christine Elms is the only candidate ready to serve the community of South Glens Falls' on their Village Board. Continue reading
Green Party National Women's Caucus endorses "March for Our Lives"
WASHINGTON, D.C. -- The National Women's Caucus of the Green Party of the United States has endorsed the March 24 "March for Our Lives" and other student walk-outs in protest of gun violence in their schools in the wake of the horrific mass murders at Marjory Stoneman Douglas High School in Parkland, Florida, on February 14, 2018, in which 17 people were killed and 14 were wounded. Slayings at schools where parents trust that their children will be safe and protected appear to be on the rise. The Chicago Tribune has written that between 2000 and 2010, of the recorded 57 shooting incidents in 36 countries, 28 of them occurred in the United States. Continue reading
Barkenhagen Appointed to Glens Falls Urban Renewal Agency
Glens Falls, NY — A former Green Party of New York candidate for local and statewide office has been appointed to the Glens Falls Urban Renewal Agency. Continue reading
V-Day Links! From GPNY
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Green Links for February 13, 2018: Victory for Democracy (not Democrats) in PA! Percoco Trial Continues, Reproductive Healthcare is a Human Right
VICTORY In Pennsylvania! And not just for Greens, but for all who support real democracy Beyond the Duopoly. PA has long been home to some of the most unjust and frustrating ballot access requirements in the nation, requiring Greens and independent candidates to collect many thousands more petition signatures to run for office than their duopoly counterparts. That has come to end, at least for non-federal statewide elections, due to the PA Green Party and allied third parties gutting this case out in the courts for six years: Continue reading
Statement Concerning Cuomo's Criminal Justice Package
The Green Party of New York State signed on to a statement released by 38 signatories addressing concerns with Governor Cuomo's criminal justice reform package. The statement is quoted below. Continue reading
Green Links For January 23, 2018
Cuomo Administration Corruption Trial Begins, Syracuse Green Gets Press, and The NY Times Spotlights Congestion Pricing Continue reading
Monroe County January 2018 Meeting
Local Greens Elect Party Officers for 2018 & Adopt Platform Plank on Combating Addiction Continue reading
Green Party Says State Budget Should Invest in Healthcare, Education, Climate Action and Affordable Housing
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VIDEO: GPNY Delivers Live, "Green State of the State Address"
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GPNY in Legislative Gazette: A green state of the state message
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Green Party of New York Mourns the Loss of Erica Garner
FOR IMMEDIATE RELEASE Contacts:Peter LaVenia, Co-chair, GPNY [email protected] Mattera, Co-chair, GPNY [email protected]; 917-886-4538 The Green Party of New York State today extended its deepest sympathies to the family of Erica Garner. Party officials said that Ms. Garner was a leading voice in the struggle against police brutality since her father, Eric Garner, died at the hands of NYC police in 2014. Party leaders noted the movement against police brutality had lost a leading light, but that it would continue to organize while remembering Erica and her father. Continue reading
Thoughts on the day after, and the next day, and the next...
Today we're proud of our Green candidates, their campaign teams, the solutions they fought for and the races they ran. Jabari Brisport ran an inspiring campaign for City Council in Brooklyn, receiving 29% of the vote and demonstrating a Red-Green Alliance for Greens and socialists around the US! In Glens Falls, Robin Barkenhagen received 35% of the vote for Councilor-At-Large, riding a swell of community support that we know will only grow with him in the fights ahead. Continue reading
Happy Election Day! Go Greens!
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Barred From Environmental Candidates Forum, Green Party Candidate Cassandra Lems Stages Protest
Nassau County - Cassandra Lems, Green Party candidate for County Executive, organized a mini-protest Sunday outside an Environmental Candidates Forum at Adelphi University. Ms. Lems and a small group of Green Party members handed out campaign literature to attendees at the forum, which was sponsored by the New York League of Conservation Voters Education Fund in partnership with Citizens Campaign for the Environment, Tri-State Transportation Campaign, Vision Long Island and Adelphi University. In late September and against last week, when Green Party members Jim Brown and Peter Louis called forum organizer Joshua Klainberg to ask that Cassandra Lems be included, they were told that Green Party candidates do not receive enough campaign contributions or media attention to be "viable." Mr. Klainberg offered to allow Ms. Lems to sit in the audience, to have her presence acknowledged, and speak to attendees after the event. However, Ms. Lems declined that offer, saying she found it "patronizing and demeaning to be expected to sit and listen to 'the real candidates' speak." Continue reading
GPNY Legislative Agenda
Green Party Calls for Single Payer Health Care, Climate Action, A Ban on Plastic Bags, and Mass Transit Funding The Green Party of New York State announced its four top state legislative priorities for 2018: enact a statewide single payer universal health care program, enact a Green New Deal to promote full employment and accelerate the transition to 100% clean energy, provide $40 billion or more in funding for mass transit in NYC and statewide, and enact a statewide ban on plastic bags. Continue reading
Green Party Calls for Single Payer Health Care; Climate Action; A Ban on Plastic Bags; and Mass Transit Funding
The Green Party of New York State announced its four top state legislative priorities for 2018: enact a statewide single payer universal health care program; enact a Green New Deal to promote full employment and accelerate the transition to 100% clean energy; provide $40 billion or more in funding for mass transit in NYC and statewide; and enact a statewide ban on plastic bags.The Party will continue to support a broader legislative agenda, including pushing for campaign finance and political reform, criminal justice reform, immigration (DREAM Act) and equal rights, local government revenue sharing, and affordable housing. Continue reading
Cassandra Lems speaks on New York Health Act and Taxation Reform
At the League of Women Voters debate* held on Sunday at Hofstra University, Cassandra Lems, Green Party Candidate for Nassau County Executive, announced her support of the New York Health Act. *A video recording of the entire candidates forum may be found here. (Event begins at 19:05.) This single payer health insurance bill, if enacted, would bring affordable and expanded health coverage to all New Yorkers, including 1.2 million currently uninsured New Yorkers. The plan would be funded through progressive payroll and self-employment taxes, coupled with a progressive assessment on income from capital gains, dividends and interest. Continue reading
Green Party of New York Declines to Endorse Constitutional Convention Vote
The Green Party of New York (GPNY) State Committee made a decision at its quarterly meeting on Saturday, September 16 to issue a statement that it would decline to endorse either the pro or con side of the New York State Constitutional Convention vote in November. Continue reading
Good Turnout in Brooklyn's 35th City Council District
By Adrienne Craig-Williams, Treasurer for Jabari 2017 Brooklyn, NY — A convivial Green primary was held in Brooklyn's 35th City Council District. Scott Hutchins and Jabari Brisport campaigned for the Green Party line throughout the late summer. Continue reading
Primary Day Means Dems and Republicans Stealing Third Party Ballot Lines Through Obscure Laws, Says Green Party of NY
One of the Dirtier Tricks From This Primary Season: Fake Mailer Using Howie Hawkins' Name and Likeness ALBANY--The Green Party of New York (GPNY) called on Gov. Cuomo and the state legislature to make immediate changes to New York election law to ban Opportunity-To-Ballot (OTB) petitions and primary elections. Green Party officers stated that OTB has been used by Democrats and Republicans to attempt to hijack the Green ballot line across the state this year. Green Party members have reported people who registered as Greens specifically to sign OTB petitions for Democratic and Republican candidates. Greens also mentioned the OTB law violates the spirit of closed primaries that are the law in New York State. Continue reading
Open Letter to Schumer and Gillibrand Opposing Israel Anti-Boycott Act - S.720
Akeem Browder for Mayor of NYC
GPNY Supports GPUS Statement on the Puerto Rican Day Parade
WASHINGTON, D.C. -- The Green Party of the United States, led by the party's Latinx Caucus, affirmed its support for the 60th annual Puerto Rican Day Parade in New York City on Sunday, June 11. "Greens called for the release of Oscar López Rivera long before President Obama commuted his prison sentence during the final days of the Obama Administration. We're pleased to see him honored as 'Procer de la Libertad' -- National Freedom Hero -- in the Puerto Rican Day Parade," said Hector López, a member of the Green Party of Connecticut. Continue reading
Cetera Announces Run for Syracuse Common Council


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Q: Hide c# object in design mode (Expression Blend) I have a DLL that contains all my object I need to build my application.
I want to hide some of them when I'm in Blend. For example, I don't want the graphic designer to use my base classes, so I need to hide them in design mode (Blend).
I tried to add [Browsable(false)] but it works only for a property or event.
I tried DesignTimeVisible(false)] but doesn't work either...
Is there a way to hide an object and not just a property?
And I need it for Blend, because sometimes you can do something in VS but not in Blend.
Thanks

A: try this inside your XAML code-behind (or similar)
if (!DesignerProperties.GetIsInDesignMode(this))
{
    // Do non-design mode stuff here}
}

redpajama_set_name: RedPajamaStackExchange


text:
Mi'kmaw lobster harvester fears for her safety after receiving online video
Angel Moore
RCMP say they're investigating video sent to Jolene Marr.
It is hard to make out what is happening in a video sent to Jolene Marr last week.
The video is about seven seconds long and it is a close up of a man's face.
It sounds like a racial slur and six gunshots in the background.
"I feel like I'm back in my racist high school where I had to be the last on the walk up to the hallway just so I didn't get jumped," said Marr.
Marr, of Sipekne'katik First Nation, and her family, are lobster harvesters. they harvest out of St. Mary's Bay in southwest Nova Scotia.
Marr said she knows who the man is in the video and took the video as a threat.
"My whole body just over come with fear because I've seen how these individuals acted in public," said Marr.
Marr is referring to the violent attacks that occurred last fall.
That is when Sipekne'katik First Nation launched their moderate livelihood fishery.
The Mi'kmaq have a treaty right to fish, hunt and gather and sell their catch.
And the Supreme Court of Canada upheld that right in 1999 in a ruling known as the Marshall Decision – that the Mi'kmaq had a right to earn a moderate livelihood, which has not been defined.
This van belonging to a Mi'kmaw harvester was destroyed by fire in Weymouth, N.S. Photo: Facebook
Over 20 years later, that has not been defined, and the Mi'kmaq are proceeding to exercise their treaty rights.
Chief Mike Sack of Sipekne'katik First Nation had been in negotiations with the Department of Fisheries and Oceans to develop a fishery management plan.
Talks fell through, Chief Sack said the DFO were trying to incorporate the fishery plan into commercial fisheries.
Non-Indigenous fishermen say the fishery is illegal. Last fall a van was burned, Sack was assaulted, and a lobster pound was burnt to the ground.
Marr says she has received threatening messages and has been followed.
"I had another older gentleman approach me and said the my brother and I are always in danger and that we should never travel alone," said Marr.
Now she is taking extra precautions to stay safe.
"I guess I kind of kept an eye on that prior to this, but I guess I just have a little sharper eye now I'm a little more cautious I feel sick to my stomach that I have to do this," said Marr.
On Oct. 13, 2020, Marr's brother Jason was surrounded in a lobster pound in West Pubnico by an angry mob of about 200 people.
He told APTN News at the time that he feared for his safety and barricaded himself inside the building while the angry mob hauled out his lobster catch and threw it on the ground.
A member of the RCMP stands and watches non-Mi'kmaw fishers haul lobster out of a pound in Nova Scotia.
The incident was captured on video and includes RCMP officers standing by and not intervening.
A few days later, the pound was burnt to the ground. No one has been charged.
But last week, the RCMP charged 23 people for the Oct. 13, 2020 incident where the lobster was destroyed.
Fifteen people were charged for break and enter, and eight people were charged with break and enter and mischief.
They are to appear in Yarmouth Provincial Court in March.
The RCMP said in a statement to APTN News that the video sent to Marr is being investigated.
Video Journalist / Halifax
Angel Moore is a proud Cree from the Peguis First Nation in Manitoba. Angel grew up in Winnipeg and has a Journalism degree from the University of King's College. She also has a degree from Dalhousie University in International Development Studies and Environmental Sustainability. Angel joined APTN News in June 2018 as the correspondent in the Halifax bureau and covers Atlantic Canada.
Tags: lobsters, Mi'maw fishery, moderate livelihood, National, Nova Scotia
Manitoba Metis Federation offering COVID-19 testing to its citizens
No Pfizer BioNTech vaccine doses to be shipped to Canada next week: Fortin


A sense of urgency can motivate us to make a decision or take an action. If you feel you need to do something there's a good chance it will get done. That's why marketing and sales pitches often appeal to our fears of scarcity (there are only so many left, so act before they're all gone) or being left out (we fear we'll regret our decision not to do something will result in a lost opportunity). This may be a good approach to selling lawn mowers but may not be the way to go when trying to settle a case.
Does Time Play a Factor in Settling a Case?
Roger Dooley's blog on neuromarketing (using psychology to sell) discusses how effective clocks and timers on some websites can be in increasing sales or the number of people completing personal information forms. Dooley states that the image of a spinning clock along with a warning that time is running out in one instance increased sales by 9% and for another website tripled the rate of form completion. If you're a business owner, that's a pretty good return for a simple line of text and an image on a webpage.
Fears of scarcity and of being left out can play a role in resolving differences. If a party is told there is only a limited opportunity to settle a case, or a party will pay less to settle as time goes on and defense costs increase, it could get a party off the fence and agree to resolve the issue.
But negotiations and mediations are not a one size fits all proposition. If a case is emotionally charged, this approach can result in people feeling rushed or forced into a corner. A party may refuse to make a decision or reject a proposal because he or she feels under pressure. If the party filed the lawsuit, they already may feel they've been wronged and may feel doubly so if pressure is brought to bear against them.
Negotiators need to use care when considering how much time should be used for mediation. A half day session may create a sense of urgency that could result in a resolution of a less heated case but that may backfire in a more emotional case. Time is of the essence, unless it's not. A whole day session may be the better option to let the parties work through their emotions and reach a resolution through a more organic process.


1. Hot glue a pair of wiggle eyes to the top of each cork. Note: oversize eyes add to the cuteness factor on these!
2. Cut small triangles from orange felt for the "beaks".
3. Cut small leaf shapes from additional colors of felt to act as the "wings".
4. Hot glue the beaks and wings onto the corks.
5. Hot glue a Hershey's KISS "winter hat" to the top of each owl!
Those are so neat. We did something similar this past Christmas with logs and the super large kisses.


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Expanded Qld disciplinary powers harmful
Legislation expanding Queensland principals' disciplinary powers was intended to decrease the number of suspensions and exclusions but has had the opposite effect, increasing the numbers of students excluded and suspended, impacting the transition from primary to secondary and feeding into the school to prison pipeline.
In 2014, the Newman government legislated to give principals greater discretion to suspend students, extend the length of short suspensions (from 1–5 to 1–10 days), and enable principals to impose community service and detentions on students outside of school hours.
Prof Linda Graham, a researcher in inclusive education at the Queensland University of Technology analysed rates of suspension, permanent exclusions, and enrolment cancellation in Queensland from 2006 to 2017.
After the legislation was introduced, exclusions briefly decreased, but reached a new high in 2017. Enrolment cancellations peaked in 2014 and decreased somewhat over the next three years. But from 2014 to 2017, suspensions per student increased by 16.67%.
While a suspension temporarily prevents a student from attending school, a permanent exclusion prohibits a student's return to a particular school. An enrolment cancellation can only be imposed on a student over 16, and ends their enrolment in the education system. All had increased between 2006 and 2014, although suspensions had started decreasing from 2011.
Graham argues that suspensions exclude students from vital learning, worsen disengagement, and increase children's risk of antisocial behaviour due to lack of supervision.
This widens the 'school to prison pipeline', with a disproportionate effect on students with a disability (especially those with ADHD or autism), Indigenous students, minority students, and students in out-of-home care.
"Taken together, the bulk of the research evidence indicates that suspension does not help to address the reasons for student disengagement and may in fact accelerate vulnerable students' disconnection from school," said Graham.
In rare circumstances, she said, suspensions and exclusions may be "necessary and justified" to protect staff and students, such as when a student engages in serious violence or brings drugs or weapons to school.
However, she said that widened powers increase schools' ability to use suspensions for the wrong reasons – such as to improve a school's performance in tests, to "reassure parents and school staff that the school is firm on behaviour", as a substitute for effective methods of improving behaviour, or to mask ineffective teaching.
"Suspension does not act as a deterrent and nor does it help to produce positive behavioural change through the application of a consequence," she said.
"For young people to benefit from the application of a consequence, they must not only be capable of considering that consequence in another future scenario, but also able to replace inadvisable behaviour with an acceptable alternative. Alternative behaviours, however, need to be explicitly taught if students are to use them."
Suspension, she said, has perverse consequences. When used to punish a student for truancy, for instance, it can encourage them to break rules to gain relief from an environment they are unhappy in.
Between 2013 and 2014, suspension rates in Queensland increased most sharply in Prep (by 50%); between 2014 and 2015, in Year 7 (by 83%).
Graham said that rising suspension rates in Prep may reflect a decline in play-based learning in early schooling and growing academic demands on children, partly due to pressure on Grade 3 students to perform in NAPLAN. She said this is especially concerning given the downward shift of Prep age in 2015.
Meanwhile, she noted that the leap in suspensions of year 7s coincided with the shift of Year 7 to high school. Previously, suspensions would leap for students entering Year 8. In her view, this indicates serious problems in the transition from primary school to high school.
"While secondary school suspensions are typically higher than primary, hormones and adolescent behaviour cannot explain the sudden and grade-specific increase identified through this analysis.
"It is inconceivable that the 2015 and 2016 Grade 7 cohorts were more 'badly behaved' than previous cohorts that remained in primary school before them. Rather, these patterns may reflect something in the nature of secondary schooling itself.
"Although it might be argued that primary schools are too tolerant and that students are being ill-prepared for transition to secondary by ineffective discipline, there is no evidence to support this interpretation."
Graham expressed approval of the present Queensland government's funding of research into implementing age-appropriate learning in state schools, but called for urgent action on suspensions.
"It is incumbent on government to act swiftly when legislative change that ignores the international research evidence does not achieve its stated purpose and could instead be fuelling increases in exclusionary practices that are known to have harmful effects."
She said other states should take heed, particularly given increases in suspensions in New South Wales, and the upcoming transition of Year 7 to secondary school in South Australia.
"This issue is not isolated to Queensland. There's a real risk that other states will face similar problems as they implement comparable reforms."
Linda Graham. (2018). 'Questioning the impacts of legislative change on the use of exclusionary discipline in the context of broader system reforms: A Queensland case study', International Journal of Inclusive Education. DOI: 10.1080/13603116.2018.1540668.


text:
High-dose cisplatin in advanced head and neck cancer
Arlene A. Forastiere, Bonnie J. Takasugi, Shan R. Baker, Gregory T. Wolf, Vickie Kudla-Hatch
In 22 patients with advanced squamous cell carcinoma of the head and neck we evaluated the efficacy and toxicity of 200 mg/m2 cisplatin administered in 3% NaCl with vigorous hydration. Six patients had previously untreated stage IV disease and 16 patients had recurrent disease, including eight with prior chemotherapy including low-dose cisplatin and carboplatin. Cisplatin was administered as a brief infusion, either 40 mg/m2/day × 5 or 50mg/m2/day × 4, every 28 days. Objective responses were observed in 16 of 22 (73%) patients, including 5 of 6 (83%) previously untreated patients and 11 of 16 (69%) patients with recurrent disease. This included two comoplete responses, one confirmed pathologically. Fifty-seven courses of drug were administered and toxicity was monitored with serial creatinine clearance determinations, audiograms, and sensorimotor exams. Neuropathy and ototoxicity were dose-limiting and led to the stopping of treatment in 12 of the 16 responders after one to four courses (median three courses). Only two responding patients continued treatment until disease progression occurred at 3 and 4 months after achieving maximum response. Acute, transient nephrotoxicity occurred in four patients; two were retreated. Moderate myelosuppression occurred in all patients but was not treatment-limiting. For most patients the maximally tolerated number of courses was three. The median survival time was 33.5 weeks for recurrent disease patients, 108 weeks for newly diagnosed patients. This regimen is not recommended for the palliation of recurrent disease. However, the very high response rate suggests that high-dose cisplatin may have a useful role in induction or adjuvant chemotherapy regimens.
Cancer Chemotherapy and Pharmacology
Head and Neck Neoplasms
Patient treatment
Induction Chemotherapy
Adjuvant Chemotherapy
Forastiere, A. A., Takasugi, B. J., Baker, S. R., Wolf, G. T., & Kudla-Hatch, V. (1987). High-dose cisplatin in advanced head and neck cancer. Cancer Chemotherapy and Pharmacology, 19(2), 155-158. https://doi.org/10.1007/BF00254569
High-dose cisplatin in advanced head and neck cancer. / Forastiere, Arlene A.; Takasugi, Bonnie J.; Baker, Shan R.; Wolf, Gregory T.; Kudla-Hatch, Vickie.
In: Cancer Chemotherapy and Pharmacology, Vol. 19, No. 2, 04.1987, p. 155-158.
Forastiere, AA, Takasugi, BJ, Baker, SR, Wolf, GT & Kudla-Hatch, V 1987, 'High-dose cisplatin in advanced head and neck cancer', Cancer Chemotherapy and Pharmacology, vol. 19, no. 2, pp. 155-158. https://doi.org/10.1007/BF00254569
Forastiere AA, Takasugi BJ, Baker SR, Wolf GT, Kudla-Hatch V. High-dose cisplatin in advanced head and neck cancer. Cancer Chemotherapy and Pharmacology. 1987 Apr;19(2):155-158. https://doi.org/10.1007/BF00254569
Forastiere, Arlene A. ; Takasugi, Bonnie J. ; Baker, Shan R. ; Wolf, Gregory T. ; Kudla-Hatch, Vickie. / High-dose cisplatin in advanced head and neck cancer. In: Cancer Chemotherapy and Pharmacology. 1987 ; Vol. 19, No. 2. pp. 155-158.
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title = "High-dose cisplatin in advanced head and neck cancer",
abstract = "In 22 patients with advanced squamous cell carcinoma of the head and neck we evaluated the efficacy and toxicity of 200 mg/m2 cisplatin administered in 3{\%} NaCl with vigorous hydration. Six patients had previously untreated stage IV disease and 16 patients had recurrent disease, including eight with prior chemotherapy including low-dose cisplatin and carboplatin. Cisplatin was administered as a brief infusion, either 40 mg/m2/day × 5 or 50mg/m2/day × 4, every 28 days. Objective responses were observed in 16 of 22 (73{\%}) patients, including 5 of 6 (83{\%}) previously untreated patients and 11 of 16 (69{\%}) patients with recurrent disease. This included two comoplete responses, one confirmed pathologically. Fifty-seven courses of drug were administered and toxicity was monitored with serial creatinine clearance determinations, audiograms, and sensorimotor exams. Neuropathy and ototoxicity were dose-limiting and led to the stopping of treatment in 12 of the 16 responders after one to four courses (median three courses). Only two responding patients continued treatment until disease progression occurred at 3 and 4 months after achieving maximum response. Acute, transient nephrotoxicity occurred in four patients; two were retreated. Moderate myelosuppression occurred in all patients but was not treatment-limiting. For most patients the maximally tolerated number of courses was three. The median survival time was 33.5 weeks for recurrent disease patients, 108 weeks for newly diagnosed patients. This regimen is not recommended for the palliation of recurrent disease. However, the very high response rate suggests that high-dose cisplatin may have a useful role in induction or adjuvant chemotherapy regimens.",
author = "Forastiere, {Arlene A.} and Takasugi, {Bonnie J.} and Baker, {Shan R.} and Wolf, {Gregory T.} and Vickie Kudla-Hatch",
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T1 - High-dose cisplatin in advanced head and neck cancer
AU - Forastiere, Arlene A.
AU - Takasugi, Bonnie J.
AU - Baker, Shan R.
AU - Wolf, Gregory T.
AU - Kudla-Hatch, Vickie
N2 - In 22 patients with advanced squamous cell carcinoma of the head and neck we evaluated the efficacy and toxicity of 200 mg/m2 cisplatin administered in 3% NaCl with vigorous hydration. Six patients had previously untreated stage IV disease and 16 patients had recurrent disease, including eight with prior chemotherapy including low-dose cisplatin and carboplatin. Cisplatin was administered as a brief infusion, either 40 mg/m2/day × 5 or 50mg/m2/day × 4, every 28 days. Objective responses were observed in 16 of 22 (73%) patients, including 5 of 6 (83%) previously untreated patients and 11 of 16 (69%) patients with recurrent disease. This included two comoplete responses, one confirmed pathologically. Fifty-seven courses of drug were administered and toxicity was monitored with serial creatinine clearance determinations, audiograms, and sensorimotor exams. Neuropathy and ototoxicity were dose-limiting and led to the stopping of treatment in 12 of the 16 responders after one to four courses (median three courses). Only two responding patients continued treatment until disease progression occurred at 3 and 4 months after achieving maximum response. Acute, transient nephrotoxicity occurred in four patients; two were retreated. Moderate myelosuppression occurred in all patients but was not treatment-limiting. For most patients the maximally tolerated number of courses was three. The median survival time was 33.5 weeks for recurrent disease patients, 108 weeks for newly diagnosed patients. This regimen is not recommended for the palliation of recurrent disease. However, the very high response rate suggests that high-dose cisplatin may have a useful role in induction or adjuvant chemotherapy regimens.
AB - In 22 patients with advanced squamous cell carcinoma of the head and neck we evaluated the efficacy and toxicity of 200 mg/m2 cisplatin administered in 3% NaCl with vigorous hydration. Six patients had previously untreated stage IV disease and 16 patients had recurrent disease, including eight with prior chemotherapy including low-dose cisplatin and carboplatin. Cisplatin was administered as a brief infusion, either 40 mg/m2/day × 5 or 50mg/m2/day × 4, every 28 days. Objective responses were observed in 16 of 22 (73%) patients, including 5 of 6 (83%) previously untreated patients and 11 of 16 (69%) patients with recurrent disease. This included two comoplete responses, one confirmed pathologically. Fifty-seven courses of drug were administered and toxicity was monitored with serial creatinine clearance determinations, audiograms, and sensorimotor exams. Neuropathy and ototoxicity were dose-limiting and led to the stopping of treatment in 12 of the 16 responders after one to four courses (median three courses). Only two responding patients continued treatment until disease progression occurred at 3 and 4 months after achieving maximum response. Acute, transient nephrotoxicity occurred in four patients; two were retreated. Moderate myelosuppression occurred in all patients but was not treatment-limiting. For most patients the maximally tolerated number of courses was three. The median survival time was 33.5 weeks for recurrent disease patients, 108 weeks for newly diagnosed patients. This regimen is not recommended for the palliation of recurrent disease. However, the very high response rate suggests that high-dose cisplatin may have a useful role in induction or adjuvant chemotherapy regimens.
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology