text:
ARM Enables Mass Industrial IoT System Deployments with Hewlett Packard Enterprise
Cambridge, UK, Feb. 23, 2016 - ARM is accelerating industrial Internet of Things (IoT) deployments with Hewlett Packard Enterprise (HPE) by enabling greater device interoperability. The companies are focused on enabling new applications for industrial automation, smart cities, environmental monitoring and smart lighting.
Scaling IoT Networks
Building a networked system of connected devices is currently very difficult as individual devices are often based on proprietary standards or they meet a range of industry standards that are not interoperable. This can make it impossible for devices to share information and it limits the capability of an IoT network.
The collaboration addresses this issue by enabling devices to be centrally identifiable, accessible and manageable. This will be achieved by HPE using ARM® mbed™ IoT Device Platform connectivity solutions that integrate all device hardware and software, manage operational deployment and facilitate analysis of device intelligence. The highly scalable solution is built on open standards and utilizes chip-to-cloud device security offered by mbed technology. It will allow enterprises to benefit from accelerated time to market and lower cost of ownership.
"Our IoT technology partnership with ARM can revolutionize connectivity moving forward," said Dave Sliter, vice president and general manager, Communications & Media Solutions, HPE. "The collaboration has the potential to bring new IoT solutions to market quickly and accelerate adoption in the enterprise of smart connected technologies."
The solution can be easily adjusted based on individual device to service needs. Built on open-standards and supported through open source software, the platform provides a future proof solution that will allow enterprise developers to focus on their core expertise (device or application development) rather than platform enablement and integration.
"The ARM and Hewlett Packard Enterprise solution will simplify the deployment of industrial IoT networks," said Dipesh Patel, executive vice president, Incubation Businesses, ARM. "It will provide a secure standard-based way of networking any number of connected devices. This offers the kind of scalable deployments companies need to deal efficiently with future growth."
Interested enterprises looking to gain a faster time-to-value in IoT markets are invited to discuss opportunities with ARM/HPE via salesinfo@arm.com.
ARM (LSE: ARM, NASDAQ: ARMH) designs technology at the heart of the world's most advanced digital products. We are enabling the development of new markets and transformation of industries and society, invisibly creating opportunity for a globally connected population. Our scalable, energy-efficient processor designs and related technologies deliver intelligence wherever computing happens, ranging from sensors to servers, including smartphones, tablets, digital TVs, enterprise infrastructure and the Internet of Things.
Our innovative technology is licensed by ARM Partners who have shipped more than 75 billion System on Chip (SoCs) containing our intellectual property. Together with our Connected Community, we are breaking down barriers to innovation for developers, designers and engineers, ensuring a fast, reliable route to market for leading electronics companies. Learn more and join the conversation at http://community.arm.com,
All information is provided "as is" and without warranty or representation. This document may be shared freely, attributed and unmodified. ARM and mbed are trademarks or registered trademarks of ARM Limited (or its subsidiaries). All other brands or product names are the property of their respective holders. © 1995-2016 ARM Group


text:
VA Shows You Must See This Week: July 10 – July 16
Marilyn Drew Necci | July 10, 2019
Topics: And Out Come The Wools, Belle And Sebastian, cement shoes, Champion RVA, Christmas In July, Digger, Ex Hex, Franks & Deans, Fun Size, gallery 5, Garden Grove Brewing, Glitterally Can't Even, Grem Smiley, Hanging From The Trio, Hardywood, Hotspit, Invaluable, Jocko, josh small, Kate Bollinger, Kevin Krauter, Kevin Seconds, Left Cross, Little Hustle, Liza & The Heart-Takers, missangelbird, Old Gods Defied, Operation Icy, Phantom Limb, Punks For Presents, Sammy Kay, Santa Flag, shows you must see, Single Use Plastic, Snowed Out, Soccer Mommy, Sprint Pavilion, Superstition, Taphouse Grill, The Broadberry, Tomb Mold, Under Attack, VE, Watchdogs, Wonderland
Saturday, July 13, 5 PM
Punks For Presents: Christmas In July, feat. Operation Icy, …And Out Come The Wools, Snowed Out, Hanging From The Trio, Santa Flag @ Hardywood – Free!
Christmas. As the old song goes, it's the most wonderful time of the year. Such a sentiment is certainly up for debate, but one thing's for sure — if there's anything you really love about Christmas, you're as far away from it now as you could possibly get. Thankfully, the folks at Punks For Presents understand that a year is an awfully long time to wait — so once again this year, they're bringing us a Christmas In July celebration to tide us over until the temperatures drop and the snow (doesn't) fall once again.
Punks For Presents have been doing their thing for years now, and it's always awesome. Not just because of the music, either — they've been hooking up the Children's Hospital of Richmond with cash and toy donations for years now, which is a cause always worth supporting. But the music itself is definitely amazing. Here's how it works — local musicians form tribute bands to classic punk, hardcore, and metal bands and come up with a killer set of that band's material. Then they rewrite the lyrics to take on a Christmas-related theme, and away we go!
This time around at Hardywood, this free gig presents five excellent holiday takes on classic bands of the 90s. Operation Icy and …And Out Come The Wools pay tribute to Tim Armstrong's punk/ska legacy. Snowed Out, a No Doubt tribute band with a very clever name, stretch a point a little, but it's all in pursuit of some fun, so I can't get too mad at it. Santa Flag finds the Alex Jonestown Massacre boys putting together a set intended to evoke Anti-Flag's early-2000s peak, while Hanging From The Trio mash up MxPx, Blink 182, and Alkaline Trio into one great set of 90s pop-punk jammers. The show is free, and the weather is great, so celebrate Christmas In July with Punks For Presents and bring the most wonderful time of the year a little bit closer.
Wednesday, July 10, 7 PM
Soccer Mommy, Kevin Krauter, Kate Bollinger @ The Broadberry – $15 in advance/$18 day of show (order tickets HERE)
Hard not to get stoked about this one. Soccer Mommy were pretty much my favorite new artist of 2018, blowing me away with their debut LP, Clean, and definitely giving me the feels with their raw, cutting lyrics on songs like "Your Dog" and "Last Girl." Granted, there are a lot of sad indie girls with guitars out there writing songs about their angst; who you are probably has a big effect on your overall tolerance for that kind of music. But if you're going to make room in your heart for even one of these artists, Soccer Mommy should be the one.
It's not even just about the lyrics (though if any of my readers are the sort of early 20s indie-boy heartbreakers that seem pretty easy to find in most music scenes, you probably need to hear these songs ASAP), it's about the fact that Soccer Mommy singer-guitarist Sophie Allison's ear for a hook is flawless, and her ability to write a memorable chorus you'll be walking around singing to yourself all day is pretty much unmatched. If you've never spent an entire afternoon with "I don't want to be your fucking dog that you drag around" running through your head, you need to get familiar with the excellent songcraft of Soccer Mommy. Tonight's the perfect time to do so.
Thursday, July 11, 7 PM
Little Hustle, HotSpit, Missangelbird, Liza & The Heart-Takers @ Gallery 5 – $7
Get your weekend started a day early this Thursday night, and break out of the work-week doldrums with a bunch of rad bands at Gallery 5. Little Hustle are coming down from New York to rock us all, and their killer sound, as demonstrated on brand new album Notepasser, finds them indulging in Asobi Seksu-style delicate shoegaze moments at times, then blasting off into hard-charging Sleater-Kinney style choruses that will have you dancing around the room before you even realize what's going on. As rad as they sound on record, they're sure to be a tremendous experience live.
Plus, you also get the tour kickoff show for two excellent local indie groups, HotSpit and Missangelbird. Missangelbird was born out of the solo songwriting adventures of Erica Lashley, who has since recruited a rhythm section and begun dishing out quietly hard-hitting versions of her precisely-constructed indie tunes. She's also a member of HotSpit, a louder, more ensemble-style indie quartet with some anthems of their own to regale the entire East Coast with over the next couple weeks. But first, they'll be rocking Gallery 5 on the way out of town, and you really shouldn't miss this chance to catch 'em before they go.
Friday, July 12, 8 PM
Franks & Deans, Glitterally Can't Even @ Wonderland – $10
This one's gonna be kind of nutty — but in a good way, I promise! Here's the deal with Franks & Deans: in the tradition of Me First & The Gimme Gimmes, they focus on punk rock versions of classic tunes. Franks & Deans dips further into the past than Me First, though, bypassing the 70s AM Gold era for a deep dive into the tunes and styles of the Rat Pack. That's right, this band does punk rock versions of songs by Frank Sinatra, Dean Martin, and their legendary associates — and sometimes they mash them up with actual classic punk tunes. For example, Bobby Darin's "Splish Splash" to the tune of Rancid's "Roots, Radicals," or Sinatra's "Luck Be A Lady" sung overtop "Ghost Town" by The Specials.
See? I told you it'd be nutty. But I think we'd all be lying if we said our interest wasn't at least a little piqued. The fact that this four-piece punk group tours with their very own dancer, Miss Nicole Muse, only furthers the Vegas-decadence vibe. You're sure to cut loose once these guys start rocking Wonderland this Friday night, and you'll be put into the perfect mood for such hijinks and tomfoolery by an opening set from local Kesha tribute act Glitterally Can't Even, who do classics like "Tik Tok" and "Animal" in a ska-punk style. It's Friday night, y'all — let's head down to Shockoe Bottom and get weird.
Jocko, WatchDogs, Cement Shoes, Old Gods Defied @ Champion RVA – Free!
Here's a really interesting hardcore group that doesn't just sound like everyone else on the scene these days: Jocko, from Omaha Nebraska. The tagline on this band is "mixing hardcore with hip hop," but the experienced HC fans among us may then expect them to sound like Cold World. However, instead of going for the Biohazard-ish intersection of metallic breakdowns and banging beats, Jocko goes a different route, mixing a more old-school, less metallic USHC sensibility that draws from both coasts with a braggodocious vocal approach that switches back and forth from angry shouts to rhythmic rhymes.
On Jocko's debut LP, Expressions, this midwestern group pulls from all sorts of different regional hardcore traditions — New York's Madball, Boston's Negative Approach, Central Cali's Trash Talk, and LA's Rage Against The Machine are all obvious influences on this group. But what really makes their music hit so hard is their strong, energetic attack, which is sure to get the pit stirred up at Champion RVA this Saturday night. They're accompanied on this gig by a triple-threat of local groups; WatchDogs' chugging low-end brutality, Cement Shoes' speedy energetic punk, and Old Gods Defied's aggressive mosh-metal thrill will get you hyped from the moment you walk in the door.
Sunday, July 14, 6 PM
Phantom Limb, VE, Grem Smiley @ Garden Grove Brewing – Free!
When you hear a band described as "postpunk," there's probably a certain image that comes into your head — one that involves laser lights piercing the gloom of a dark hazy club as a band dressed in all black does its level best to sound like Joy Division. Phantom Limb can easily be called postpunk, but they are definitely not that kind of band. Instead, on their 2017 LP Townies, they tap into a wild rock n' roll energy that lands somewhere between the spooky garage punk of bands like Ex-Cult and the synth-punk madness of Lost Sounds, all while keeping an atmosphere of intriguing mystery floating around.
When Phantom Limb hit the stage at Garden Grove Brewing this Sunday night, they're gonna cap your weekend off with a bang — one that'll thrill you whether you're wearing thick black eyeliner or not. You will also get to enjoy the unique stylings of VE, who at least at one time were named Various Eggs and may still be. Their music is strange, and not too much like anything else you're going to hear anywhere, but "postpunk" would also be a fair categorization of it. And "very good" would be too. The show will begin with some rad rock n' roll from local newcomers Grem Smiley. This one's gonna be fun.
Monday, July 15, 7 PM
Kevin Seconds, Josh Small, Sammy Kay @ Gallery 5 – $15 (order tickets HERE)
You've really gotta love this. Hardcore pioneer Kevin Seconds, who began his legendary, long-running group 7 Seconds at the very dawn of the 80s and went on to influence multiple generations of punks with his patented blend of unflinching socio-political commentary, hardcore energy, and unforgettable melodic hooks, has been performing solo acoustic shows off and on since the late 80s. These days, with 7 Seconds having finally ended in 2018 after nearly 40 years, catching him solo is certainly your best bet — and with his solo tunes, most recently brought into the world on his 2016 album Band-Aid On A Bullet Wound, carrying every bit the high quality 7 Seconds' music always had, it's a guarantee of a fun musical evening.
What might be the most fun about this particular gig is that Kevin Seconds is wearing his reason for this particular East Coast tour on his sleeve. As the poster says: he's come for Avail. Kev will hit the Gallery 5 stage four days before Avail begins its run of reunion gigs over at The National, and it's delightful to see an absolute pioneer of punk rock still so excited about music 40 years into his career that he'd book an entire tour around that opportunity. It's to all our benefit, too, as it offers us all a chance to see Kevin Seconds play Richmond for the first time in quite a while. Come out and see what sort of tunes he has to offer — we can guarantee you'll enjoy them.
Tuesday, July 16, 7 PM
Tomb Mold, Superstition, Left Cross, Under Attack @ Gallery 5 – $12 (order tickets HERE)
Look, sometimes we've just gotta get down with some serious brutality. When you're as stoked about metal as I am, it's hard to get through even one week without it. But even if total headbanging action isn't your preferred version of musical enjoyment, even you have got to recognize that sometimes you've just gotta thrash. Tomb Mold is coming through town this Tuesday night, and they'll be offering you the perfect opportunity for such a thing. Brutal riffage in a classic old-school death metal style to bring smiles to the faces of all the Autopsy, Obituary, and Incantation fans out there — that's what they've got to offer. You should really take them up on it.
They'll be joined in their trek through RVA by Superstition, a Santa Fe, NM ensemble with a similarly old-school approach to death metal madness. If you dug those old Earache cassettes your uncle used to blast in his car, these groups are really gonna make you happy. They're joined on this bill by RVA's own dirty thrashin' death-metallic hardcore powerhouse, Left Cross, as well as brand new Richmond hardcore supergroup Under Attack, which features members of Limp Wrist, Suppression, Municipal Waste, and Red 40 (not the one from Tennessee a long time ago, the one from Richmond an even longer time ago — yeah, I remember). This whole show is definitely gonna be worth your time, so mark your calendars.
Elsewhere Around The State:
Belle And Sebastian, Ex Hex @ Sprint Pavilion – $36-$50 (order tickets HERE)
It's hard to believe that indie darlings Belle And Sebastian have become popular enough to play the 3500-seat Sprint Pavilion in Charlottesville. But if anything, it shows the buying power of grown-ups who were indie kids in their college days. So this one is for everybody who booked a sitter months in advance so they can enjoy a lovely evening with their partner smiling to classic tunes like "Dylan In The Movies" and "Piazza, New York Catcher." But that doesn't mean the rest of us can't go too, and enjoy the many wonderful highlights of Stuart Murdoch and co.'s consistent career of outstanding tunes.
Belle And Sebastian have decidedly not become just a 90s nostalgia act, either. They're preparing to release their 11th album, a soundtrack for English film Days Of The Bagnold Summer (the directorial debut of Inbetweeners star Simon Bird), later this year. First single "Sister Buddha" shows that this seven-person Scottish ensemble have still got what it takes to create indie-pop classics every bit the equal of the ones they were dishing out with regularity over 20 years ago. This certainly bodes well for an evening of excellent music. Plus, you'll get an opening set from Ex Hex, the dynamic Mary Timony-led rock n' roll trio whose recently released It's Real makes clear that their awesome, swaggering debut, Rips, was no fluke. Even if you can only afford the cheap seats, this one's essential.
Digger, Fun Size, Invaluable, Single-Use Plastic @ Taphouse Grill – $13 in advance/$15 day of show (order tickets HERE)
OK so here's another 90s throwback for all the music fans among us, though this one will certainly be more intimate, taking place at Norfolk's Taphouse Grill. It finds two 90s pop-punk legends coming together once again. Digger are the first ones we must discuss — this Pennsylvania band cranked out some outstanding albums on Hopeless Records in the late 90s and early 2000s, the best being the prescient Promise Of An Uncertain Future. Today, when we're all living in that very uncertain future, Digger have returned to action and hit the road once again, regaling all us 90s kids who miss the innocent days of our teenage angst, when getting a ride to the show at Twisters on Friday night was our biggest concern.
Fun Size is the other pop-punk legend on this bill, and chances are they were also on the bill of that show we were all trying to get a ride to 25 years ago. Having released a couple of outstanding albums back then, these guys returned to action at the dawn of this decade with a long awaited third LP, Since We Last Spoke. That album proved that they were still every bit the world-class talents they'd always been, and seven years later, they're still proving it. Seeing these guys on a bill with Digger is sure to take you back to your teenage days, even if you don't quite fit into those tiny t-shirts you used to wear back then. That's OK — I'm sure the bands would be glad to sell you new ones after the gig. Get there and rock out like there's still a Clinton in the White House.
Email me if you've got any tips for me about upcoming shows (that take place after the week this column covers -– this week's column has obviously already been written): [email protected]
Music Sponsored By Graduate Richmond

redpajama_set_name: RedPajamaCommonCrawl


This post is sponsored by MELT® Organic and Tap Influence. As always, all opinions and recipe are my own. Thanks for supporting the brands who support Shared Appetite. #ButterImprovement A better-for-you version that's also gluten-free! These Skinny Jalapeno Kale Cornbread Muffins are packed with flavor and make for a perfect side dish! I currently have two choices….


Authentic Music are now well and truly back; after a lengthy hiatus from releasing music and a couple of retrospective EP releases, the Czech label returns proper this month with a various artists LP in the form of Art of Deception.
It's worth noting at this point that I'm not a big fan of compilation LPs. Certain labels have taken in recent years to releasing ever bigger and bigger albums packed with twenty, thirty or even forty tunes loosely bound by rough subgenre and largely lacking in vision or purpose; sure, there are often some good tracks to be found, but who wants to listen through dozens of beats to find the gems? Quality before quantity should be the maxim, but more and more in this ADHD digital age that maxim is being ignored.
Enter Authentic Music, a label that has always striven to provide that all important quality. In the three and a half years of its existence, the imprint has moved slowly but steadily, releasing only tracks which pass the tests of both production sheen and innovation, and thankfully that ethos hasn't changed for their latest outing.
The slightly old school approach shines through in the release of samplers, a-la vinyl LPs of yesteryear; there might not be wax in the offing, but a handful of tracks have been selected from the main body to lead the pack, and in that fine tradition of samplers they feature some of the LP's strongest material, with remixes from A-Cray and ArpXP sitting alongside originals from Revaux and Kusp.
Tone-wise most of the album holds true to the Authentic aesthetic; techy vibes fit for the dancefloor but featuring strong sound design and enough of an experimental edge not to be forgettable club fodder. There are some surprises to be found too such as Revaux's uplifting remix of Mr. Magician and the playful rolling melodies of Dephzac's sublime Sum Is Wrong.
I could spend time picking out favourites from the selection but with the quality so high you're better off just listening for yourself. Wicked vibes through and through; hit up Beatport to grab the lot right now.
This week's Dojo Damager comes courtesy of Lincoln-based production duo Soligen & Type-2 who bring a wicked slice of modulated tech funk to Nurtured Beatz. Amping things up a bit compared to some of the imprint's deeper releases, It Gets Lively rolls hard and heavy with crispy breaks and a moving, scuzzed up bassline. Punchy business! Hit up the Nurtured Beatz Bandcamp to grab this one right now, with full release coming next week.
The mixes are coming thick and fast this month as we welcome The Untouchables to the DNB Dojo decks! With a superb new EP just out on Translation Recordings and previous releases gracing the likes of Alphacut, Cylon and Samurai, their distinctive dubby sound has been rumbling the bassbins at Dojo HQ for some time now. Serious weight!
Given that all three artists involved in the latest release for Terra Null have contributed mixes to the Dojo Mix Series, it probably comes as no surprise that the release proved to be right up our street!
Label boss Cirrus turns in two tracks for the remix treatment; on the A side Fearful dishes up a menacing new mix of Diacria; throbbing bass, rapid fire staccato percussion and tons of atmosphere on this one.
Not to be outdone, Fuj keeps things gritty and ominous on the flip with a creeping remix of Angel. The progression on this one is fantastic, particularly the eerie synth melody that ramps up in the second half of the tune. Wicked stuff; check out the clips below and hit up the Terra Null Bandcamp to grab this right now.
Agressor Bunx makes his second entry in the Dojo Damager series with another absolute stomper, this time for Bad Taste Recordings! The aptly named Total Destroy is a straight up neurofunk power play, building tension with hammering snare riddims and throbbing bassline gristle before dropping into full roll madness. The scuzz on the low end in this tune is just unbelievably satisfying; get ready for this one to wreck floors!
Total Destroy drops this Friday with B-side Crusader exclusively on Beatport, so check out the clip to wet your appetite and keep an eye out! If you're hungry for more Bunx action then check out his mix for the Bad Taste Podcast here…gnarly business.
Following hot on the heels of our last mix from Fuj, Terra Null Recordings boss Cirrus steps up with the 25th instalment of the DNB Dojo Mix Series! Whether via the excellent releases on Terra Null or his other work for Terabyte, Nurtured Beatz and AutomAte, Cirrus has been making waves within the dark D&B world for a couple of years and that looks set to continue.
His selection for DNB Dojo features new dubs from the catalogues of Terabyte, Alchemic Breaks and Terra Null alongside a host of Cirrus productions and beats from the likes of Ruffhouse, Red Army and Skeptical. Militant head nodders and grimey textures all the way on this one.


Minimum Order Quantity :- 50 Boxes.
Colour and Temperature : Upto 1400 Deg C, Colour White Black and Yellow.
Mainly Used in Steel Plants for Marking Purpose on Hot Surface like Billets, Blooms, Bars, Ingots, Ductile Iron Pipe, Spun Pipe etc.
Century's Hot Marking Chalk is a unique tool to mark onto red hot surfaces. It is widely used in industrial applications for coding & identification purposes.
Rose trye marker is specially made for smooth writing on tyres and rubbers.
The Marking Chalk are provided by us is durable, damage-resistant and long-lasting.
This product is manufactured for specially Hot/Cold Graphite Electrode, Steel Ingot, Tyres, Tubes and Wood in forest Deportment and Other Things for marking.
This product is wild used in garments, textiles and leathers.
Jai Shree Shyam Trading Co.


Description: Ocean energy is one of the largest unexplored potential energy sources. Oceans contain huge amount of kinetic energy but cost efficient energy conversion devices are still in the early stages. There is more energy in deeper water, as waves reach the shallower water near coasts, they begin to lose energy through friction with the seabed and eventually break on the shore.
 Cost efficient energy conversion devices are still in the early stages.
World wave energy resource. The numbers represent average energy flux [kW/m].
 Many sites with strong tidal streams  Some of the highest tidal ranges in the world.
· Calculated as watts per unit of area as a function of the density of the water and the cube of the speed of the water.
 Tides have been accurately predicted for hundreds of years  Satellites can measure waves out in the ocean one to two days in advance of their impact on coastal locations.
· Predications allow utilities to manage these renewable energy sources more effectively than others.
· Enormous potential = Research · DOE Report lists over 100 different technologies · Many in conceptual stage, few have field testing, even fewer as prototype or full scale device.
· First site to allow testing on grid-ready prototype projects · First connection of wave generator to Grid.
· Great potential, but mostly R&D now · Some Experts say not commercially feasible because not technologically ready.
 has had mechanical problems and brought several machines offline.  Main Financier has financial problems and is not giving any new money.
 No longer working on Tidal Stream products,  Focusing on Wavepower device "Oyster"
· Oscillator fixed to the nearshore sea bed. · Waves pump high pressure water through a sub-sea pipeline to the shore. · Onshore conventional hydro-electric generators convert high-pressure water into electrical power. · Designed with a peak power of 300-600kW per Oyster, a commercial farm of just ten devices could provide clean renewable energy to a town of 3,000 homes.


MultiStart - download current version.
OST 2 PST conversion to convert ost file of MS Exchange Server to pst file.
Excellent computer tool gainings from the best in download directories! Investigate the asked-for programs categories, see the latest versions of the asked-for solutions, and download now! Do not toss away an advantage to setup the greatest tools: apply SoftEmpire directory to recieve programs for free. Meet the website of shareware and software program trials. pick out among Windows and Linux programs, obtain controllers, playgames, and all other varieties of apps for your PC or mobile gadgets!
Best PC utility software, free to download and handy to use. Download now! System software downloads for newest versions and fresh updates. Hard disk utility software to define the status and manage all varieties of disk drives. Must - have utility software for Windows 7 to improve your system performance.
MultiStart is a shell extension for Windows 95/98. The program fits to the trayicon bar and serves to summarize to groups and to start simultaneously various applications. Arbitrarily many program groups can be created.


Vernon, CA. – Today, ELCO Lighting, a premiere luminaire manufacturer, announced that their new line of commercial LED downlights has exceeded expectations. After 3 years in development, the line was introduced to distributors on mid-2016, and sales have been thriving ever since.
"When we were designing the product line," said Brandon Cohen, at ELCO Lighting, "I pushed our team to make sure we had great light quality, top-of-the-line components, a super low glare cutoff, and a beautiful design—all at an affordable price. I am happy that they met these demands."
As brick-and-mortar businesses face more and more online competition, owners are looking for unique ways to bring attention to their stores. Lighting has been proven to have a huge effect on shoppers, even helping to determine which stores they enter and how much money they will spend. When ELCO brought its expertise into the commercial field, combining energy-efficient LEDs with durable housing materials, the response was electrifying.
Designed and assembled in the US, the full line offers a variety of commercial-grade features that easily meets the needs of retail, hospitality, industrial, and medical buildings. Driven by feedback from engineers, contractors, and lighting designers, ELCO is committed to continue its development of state-of-the-art LED products.
About the company: ELCO Lighting was founded in 1990, in the heart of Los Angeles, with a simple vision to offer high-quality light fixtures at fair market price. The company offers an expanding LED product line that contains recessed, track, under-cabinet, pendant, outdoor, pathway, and emergency lights.


Big Time Gaming is one of the smaller scale developers that contribute casino games to game providers. The company was founded by top gaming experts in the world. The company's founder, who is also the CEO, Nic Robinson has been in the business for over the years. The company is based in Australia and is licensed by Alderney Gambling Control Commission. Their games are available in several different countries and in twenty other languages with Russian, Japenese and Chineselanguages as just a few of them. The company also has links to OpenBet and CORE gaming. Its customers are also well-established firms that operate under strict jurisdictional guidelines.
Big Time Gaming Casino Slots is a small scale developer founded in 2011. The company has an extensive record of developing games since it was built by experts in the gaming world. The full management team have over 30 years of experience. Its founder who is also its CEO has been on the frontline of the gaming industry since 1996 after founding NT Media. The company's biggest pride is being among the best in innovation and compete online with other well known international companies that also make slots for casinos.
Big Time Gaming is based in Sydney, Australia and is licensed by Alderney Gambling Control Commission. The company creates innovative slot machine games and gaming products for the online gaming industry. Its customers are well established B2C gaming firms which operate under strict jurisdictions. Their games are available in several other countries and in several other different languages including Japanese Russian and French. The company constantly makes new releases and they are usually in connection with other companies such as Openbet, MGS and GTS. You can find their products on Big Time Gaming casino and also at other online casinos.
Big Time Gaming Casino List – Where Can I Play?
Big Time Gaming games are usually bundled together with other developers' at online casino sites. To play these games, you can choose from a variety of online casinos. A few of these casinos are Bet365 casino which offers Sports, Poker, Casino, Bingo and Skill Games, Limo Play Casino which offers slot games, table games, and other specialities and BETAT casino.
Videoslots Casino is one of the online casinos that gets supplies from Big Time Gaming. The casino offers players a variety of gaming options. The game offers an abundant selection of bonus video slots and if you prefer table games, the casino offers plenty of these too. The casino offers free spins and amazing bonuses to its customers every time you play This is a great casino with a variety to choose from, making it a favourite among casino lovers.
Slotsmillion Casino is another of the many Big Time Gaming clients. The online casino boasts of diversity with an amazing interface and a wide selection of more than 1100 bonus video slots. The casino is licensed by Curacao and Malta. Players can enjoy titles from more than 10 different platforms, each with a variety of themes, paytables, and bonus features. This Casino specialises in only slots; no table games, video pokers, or other casino games are available at this time.
PokerStars Casino is also another casino that gets its slots supplies from Big Time Gaming. This is one of the largest online poker brands in the industry. This online casino offers a variety of virtual and live casino games. The game is accessible through their website. Players who would love to have a real time casino experience without having to go to a casino can give it a try against dealers in PokerStars Live Casino.
Big Time Gaming continues to make new releases, while also making improvements on their current games. They have a popular cartoon look that is appealing to most slot fans.They also have popular games such as Lucky Streak and Golden goals, two games that offer players a lot of playability via bonuses such as 'Go for goal' and 'Cash Stoppa'. There are also a wide variety of themes that range from Scary haunted house to the ornithological orientated Feathered Frenzy. All these games do come with bright graphics and fun animations.
Big Time Gaming slots are designed to be played by a variety of players. Many of these games offer a wide variety of line and line-bet combinations to choose from, with bets starting from a minimum of just 0.01 coins a spin, but if you are a high roller, the games offer a maximum spin per stake of up to 400 coins.The game also offers a chance to win bigger prizes with many of these bonuses paying up to 10,000 coins. With all these amazing features that these slots offer, it's quite easy to see why they are so popular worldwide.
Big Time Gaming focuses mostly on player entertainment. Their software supports a variety of high-end games for several casinos and they easily integrate with most casino systems giving customers the best of gaming experience. The games are well known for offering high-quality graphics that are seamless too and do not need any additional software. The game has innovative and detailed themes that offer players unique bonus rounds and amazing gameplay features. The game's generous bonuses, high payouts, high RTP and extreme promotions of their free play are big bonuses for players. The company has a way of encouraging responsible gambling by allowing players to regulate the amount they would wish to gamble with.
AboutSlots is the most relevant resource for any news and views coming from the casino world. Players can identify where to play, new slots, as well as other old favourite slots. Here you can also find the best information about casino bonuses and free play that the games offer and not forgetting honest reviews about games.
Welcome to TTR Casino! Play Now And Get 100% Up To €1000 Bonus + 20 No-Deposit Free Spins!
Welcome to SlottyVegas Casino! Register Today and get a 100% up to €500 + 50 Free Spins Bonus.


One of the first symptoms is itching, and it occurs within a few hours to a few days after infestation.
You may notice burrows, which are small tracks between your fingers where the mites dig into the skin.
The scabies might lay eggs or leave feces in the burrows.
When the scabies bite, they leave very itchy, tiny red bumps.


text:
Reporter tells of her adjustment to living, working and connecting with remote communities in the Western Isles
For community reporter Eve McLachlan, it has been a real adjustment to living in the Western Isles and reporting on its remote communities. The 24-year-old, who works for the Press and Journal, originally moved to the island chain off the…
Community News Project
How the new raft of community reporters are building bonds and making an impact
A new raft of community reporters say they have uncovered hidden gems as they engage with people whose stories are normally left untold.
NCTJ awards highlight innovation and diversity in journalism education and training
Three awards which celebrate innovation and diversity in journalism education and training were presented at the NCTJ Awards for Excellence, sponsored by News UK.
Community News Project welcomes fourteen additional publishers as Meta expands scheme
Fourteen publishers are joining the Community News Project (CNP), as the scheme expands with £6 million funding from Meta.
Community News Project to create 100 roles as Meta expands scheme with $8 million funding
The Community News Project will create up to 100 community reporter roles, as the scheme is expanded with new funding.
Journalism Matters: Patrick Graham, Liverpool ECHO
"Reporting on and about a community that you live, socialise and have worked in is important to me."
Journalism Matters: Sophie Skyring, Norwich Evening News
It has meant the world to me to be given an opportunity to stand with those young people that feel they aren't good enough.
Journalism Matters: Oliver Adams, Liverpool ECHO
"Reflecting upon the ghastly historic coverage of my community, one thing rings true: words have power. And by proxy, the press has the power to influence public opinion. As a journalist, I consider it my duty to play my role in the drive for positive social change."
How a Community News Project reporter's relationship with a charity champion has made an impact and helped instil trust in journalism
A charity champion has described how her relationship with a community news reporter has really made an impact within the black community and helped instil trust in the media.


text:
In today's workplace there are numerous situations that can cause problems for employers that need to be followed up on and investigated by HR. These include claims of harassment, claims of discrimination, claims of hostile environment, claims of retaliation, claims of improper pay practices, and many more claims of improper management practices. HR usually ends up with the responsibility for conducting these investigations. Companies that opt not to conduct investigations generally do not correct situations on which these claims are made and ultimately end up in court costing them tens of thousands, if not hundreds of thousands of dollars. Improperly conducting investigations can be nearly as damaging to the company. We will learn about the steps of a proper investigation and why it is important to lay the ground work for a good investigation.
The purpose of this course is to teach the proper methods for conducting a workplace investigation.
Planning for an investigation
Who should conduct the investigation
What documentation should be gathered
What fact finding consists of
How to weigh the evidence
How to make a decision
How to prepare the report
What happens after the investigation
Learn the significance of a workplace investigation and the best practices for conducting one.
Office managers
Executives with hiring responsibility
Areas of Expertise: Human Resources
Michael D. Haberman is Vice-President and co-founder of Omega HR Solutions, Inc., a consulting and services company offering complete human resources solutions. Mike brings years of experience in dealing with the challenges of Human Resources in the 21st century. He helps companies work on compliance today to make them ready for the future tomorrow.
Mike is the author of the Human Resources blog found at OmegaHRsolutions.com, which has been recognized several times as a Top 25 in human resources related blogs. It has consistently been named as a top HR blog to read. He has been selected as one of six HR bloggers to be featured on the online version of Human Resources Executive Magazine. He has also been named in the Top 10 Digital Influencers in Human Resources and most recently has been named to the top 65 most influential HR pros on Twitter.
Mike has gained a reputation as a compliance expert. He speaks on a variety of subjects to business associations, human resource associations,and business based civic clubs. He has presented webinars on various HR related issues.
how to conduct an investigation in the workplace how to conduct workplace investigations how to do workplace investigations discrimination in the workplace investigation at work procedures formal investigation meeting at work conducting effective workplace investigations
Event : How to Conduct Workplace Investigations - Best Practices And Know How's
Speaker :Michael D. Haberman


text:
Sodium–Calcium Exchangers of the SLC8 Family in Oligodendrocytes: Functional Properties in Health and Disease
Samantha A. Spencer
Edna Suárez-Pozos
Miguel Escalante
Yu Par Myo
Babette Fuss
The solute carrier 8 (SLC8) family of sodium–calcium exchangers (NCXs) functions as an essential regulatory system that couples opposite fluxes of sodium and calcium ions across plasmalemmal membranes. NCXs, thereby, play key roles in maintaining an ion homeostasis that preserves cellular integrity. Hence, alterations in NCX expression and regulation have been found to lead to ionic imbalances that are often associated with intracellular calcium overload and cell death. On the other hand, intracellular calcium has been identified as a key driver for a multitude of downstream signaling events that are crucial for proper functioning of biological systems, thus highlighting the need for a tightly controlled balance. In the CNS, NCXs have been primarily characterized in the context of synaptic transmission and ischemic brain damage. However, a much broader picture is emerging. NCXs are expressed by virtually all cells of the CNS including oligodendrocytes (OLGs), the cells that generate the myelin sheath. With a growing appreciation of dynamic calcium signals in OLGs, NCXs are becoming increasingly recognized for their crucial roles in shaping OLG function under both physiological and pathophysiological conditions. In order to provide a current update, this review focuses on the importance of NCXs in cells of the OLG lineage. More specifically, it provides a brief introduction into plasmalemmal NCXs and their modes of activity, and it discusses the roles of OLG expressed NCXs in regulating CNS myelination and in contributing to CNS pathologies associated with detrimental effects on OLG lineage cells.
Oligodendrocyte Myelin Sodium–calcium exchangers Ion homeostasis Signaling
Special Issue: In honor of Professor Michael Robinson.
Samantha A. Spencer and Edna Suárez-Pozos have contributed equally to this manuscript.
The authors are supported by Grants from the National Institute of Health (Grant No.: R01NS045883; BF), the National Multiple Sclerosis Society (Grant No.: RG-1506-04546; BF) and the Commonwealth Health Research Board (Grant No.: 236-04-17 BF).
The authors declare that they have no potential conflicts.
Kawamoto EM, Vivar C, Camandola S (2012) Physiology and pathology of calcium signaling in the brain. Front Pharmacol 3:61. https://doi.org/10.3389/fphar.2012.00061 CrossRefPubMedPubMedCentralGoogle Scholar
Brini M, Calì T, Ottolini D, Carafoli E (2014) Neuronal calcium signaling: function and dysfunction. Cell Mol Life Sci 71:2787–2814. https://doi.org/10.1007/s00018-013-1550-7 CrossRefPubMedGoogle Scholar
Horigane S-I, Ozawa Y, Yamada H, Takemoto-Kimura S (2019) Calcium signalling: a key regulator of neuronal migration. J Biochem 165:401–409. https://doi.org/10.1093/jb/mvz012 CrossRefPubMedGoogle Scholar
Toth AB, Shum AK, Prakriya M (2016) Regulation of neurogenesis by calcium signaling. Cell Calcium 59:124–134. https://doi.org/10.1016/j.ceca.2016.02.011 CrossRefPubMedPubMedCentralGoogle Scholar
Shigetomi E, Patel S, Khakh BS (2016) Probing the complexities of astrocyte calcium signaling. Trends Cell Biol 26:300–312. https://doi.org/10.1016/j.tcb.2016.01.003 CrossRefPubMedPubMedCentralGoogle Scholar
Verkhratsky A, Untiet V, Rose CR (2019) Ionic signalling in astroglia beyond calcium. J Physiol. https://doi.org/10.1113/JP277478 CrossRefPubMedGoogle Scholar
Färber K, Kettenmann H (2006) Functional role of calcium signals for microglial function. Glia 54:656–665. https://doi.org/10.1002/glia.20412 CrossRefPubMedGoogle Scholar
Brawek B, Garaschuk O (2013) Microglial calcium signaling in the adult, aged and diseased brain. Cell Calcium 53:159–169. https://doi.org/10.1016/j.ceca.2012.12.003 CrossRefPubMedGoogle Scholar
Zhang M, Liu Y, Wu S, Zhao X (2019) Ca2+ Signaling in oligodendrocyte development. Cell Mol Neurobiol 39:1071–1080. https://doi.org/10.1007/s10571-019-00705-4 CrossRefPubMedGoogle Scholar
Pitman KA, Young KM (2016) Activity-dependent calcium signalling in oligodendrocyte generation. Int J Biochem Cell Biol 77:30–34. https://doi.org/10.1016/j.biocel.2016.05.018 CrossRefPubMedGoogle Scholar
Butt AM (2006) Neurotransmitter-mediated calcium signalling in oligodendrocyte physiology and pathology. Glia 54:666–675. https://doi.org/10.1002/glia.20424 CrossRefPubMedGoogle Scholar
Soliven B (2001) Calcium signalling in cells of oligodendroglial lineage. Microsc Res Tech 15:672–679CrossRefGoogle Scholar
Cheli VT, Santiago González DA, Spreuer V, Paez PM (2015) Voltage-gated Ca++ entry promotes oligodendrocyte progenitor cell maturation and myelination in vitro. Exp Neurol 265:69–83. https://doi.org/10.1016/j.expneurol.2014.12.012 CrossRefPubMedGoogle Scholar
Burgoyne RD, Helassa N, McCue HV, Haynes LP (2019) Calcium sensors in neuronal function and dysfunction. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a035154 CrossRefPubMedGoogle Scholar
Schrank S, Barrington N, Stutzmann GE (2019) Calcium-handling defects and neurodegenerative disease. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a035212 CrossRefPubMedGoogle Scholar
Berridge MJ (2014) Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia. Cell Tissue Res 357:477–492. https://doi.org/10.1007/s00441-014-1806-z CrossRefPubMedGoogle Scholar
Shigetomi E, Saito K, Sano F, Koizumi S (2019) Aberrant CalciuASN Neuro m signals in reactive astrocytes: a key process in neurological disorders. Int J Mol Sci. https://doi.org/10.3390/ijms20040996 CrossRefPubMedPubMedCentralGoogle Scholar
Verkhratsky A, Rodríguez-Arellano JJ, Parpura V, Zorec R (2017) Astroglial calcium signalling in Alzheimer's disease. Biochem Biophys Res Commun 483:1005–1012. https://doi.org/10.1016/j.bbrc.2016.08.088 CrossRefPubMedGoogle Scholar
Nedergaard M, Rodríguez JJ, Verkhratsky A (2010) Glial calcium and diseases of the nervous system. Cell Calcium 47:140–149. https://doi.org/10.1016/j.ceca.2009.11.010 CrossRefPubMedGoogle Scholar
Blaustein MP, Lederer WJ (1999) Sodium/calcium exchange: its physiological implications. Physiol Rev 79:763–854CrossRefGoogle Scholar
DiPolo Reinaldo, Beauge L (1987) Plasma membrane mechanisms for intracellular calcium regulation in squid axons. Acta Physiol Pharmacol Latinoam 37:437–444PubMedGoogle Scholar
Khananshvili D (1990) Distinction between the two basic mechanisms of cation transport in the cardiac Na(+)-Ca2+ exchange system. Biochemistry 29:2437–2442. https://doi.org/10.1021/bi00462a001 CrossRefPubMedGoogle Scholar
Reeves JP, Condrescu M, Chernaya G, Gardner JP (1994) Na+/Ca2+ antiport in the mammalian heart. J Exp Biol 196:375–388PubMedGoogle Scholar
Baker PF, Blaustein MP, Hodgkin AL, Steinhardt RA (1969) The influence of calcium on sodium efflux in squid axons. J Physiol 200:431–458. https://doi.org/10.1113/jphysiol.1969.sp008702 CrossRefPubMedPubMedCentralGoogle Scholar
Reyes RC, Verkhratsky A, Parpura V (2012) Plasmalemmal Na+/Ca2+ exchanger modulates Ca2+-dependent exocytotic release of glutamate from rat cortical astrocytes. ASN Neuro. https://doi.org/10.1042/AN20110059 CrossRefPubMedPubMedCentralGoogle Scholar
Parpura V, Sekler I, Fern R (2016) Plasmalemmal and mitochondrial Na(+) -Ca(2 +) exchange in neuroglia. Glia 64:1646–1654. https://doi.org/10.1002/glia.22975 CrossRefPubMedGoogle Scholar
Roome CJ, Power EM, Empson RM (2013) Transient reversal of the sodium/calcium exchanger boosts presynaptic calcium and synaptic transmission at a cerebellar synapse. J Neurophysiol 109:1669–1680. https://doi.org/10.1152/jn.00854.2012 CrossRefPubMedGoogle Scholar
Jeon D, Yang Y-M, Jeong M-J et al (2003) Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2. Neuron 38:965–976. https://doi.org/10.1016/s0896-6273(03)00334-9 CrossRefPubMedGoogle Scholar
Molinaro P, Viggiano D, Nisticò R et al (2011) Na+–Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory. J Neurosci 31:7312–7321. https://doi.org/10.1523/JNEUROSCI.6296-10.2011 CrossRefPubMedPubMedCentralGoogle Scholar
Molinaro P, Cuomo O, Pignataro G et al (2008) Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. J Neurosci 28:1179–1184. https://doi.org/10.1523/JNEUROSCI.4671-07.2008 CrossRefPubMedPubMedCentralGoogle Scholar
Pignataro G, Sirabella R, Anzilotti S et al (2014) Does Na+/Ca2+ exchanger, NCX, represent a new druggable target in stroke intervention? Transl Stroke Res 5:145–155. https://doi.org/10.1007/s12975-013-0308-8 CrossRefPubMedGoogle Scholar
Jeffs GJ, Meloni BP, Sokolow S et al (2008) NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia. Exp Neurol 210:268–273. https://doi.org/10.1016/j.expneurol.2007.10.013 CrossRefPubMedGoogle Scholar
Sirabella R, Sisalli MJ, Costa G et al (2018) NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson's Disease. Cell Death Dis 9:725. https://doi.org/10.1038/s41419-018-0775-7 CrossRefPubMedPubMedCentralGoogle Scholar
Takuma K, Ago Y, Matsuda T (2013) The glial sodium-calcium exchanger: a new target for nitric oxide-mediated cellular toxicity. Curr Protein Pept Sci 14:43–50CrossRefGoogle Scholar
Noda M, Ifuku M, Mori Y, Verkhratsky A (2013) Calcium influx through reversed NCX controls migration of microglia. Advances in experimental medicine and biology. Springer, Boston, pp 289–294Google Scholar
Boscia F, Gala R, Pannaccione A et al (2009) NCX1 expression and functional activity increase in microglia invading the infarct core. Stroke 40:3608–3617. https://doi.org/10.1161/STROKEAHA.109.557439 CrossRefPubMedGoogle Scholar
Khananshvili D (2013) The SLC8 gene family of sodium-calcium exchangers (NCX)—structure, function, and regulation in health and disease. Mol Aspects Med 34:220–235. https://doi.org/10.1016/j.mam.2012.07.003 CrossRefPubMedGoogle Scholar
Lytton J (2007) Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport. Biochem J 406:365–382. https://doi.org/10.1042/BJ20070619 CrossRefPubMedGoogle Scholar
Carafoli E (1987) Intracellular calcium homeostasis. Annu Rev Biochem 56:395–433. https://doi.org/10.1146/annurev.bi.56.070187.002143 CrossRefPubMedGoogle Scholar
Philipson KD, Nicoll DA (2000) Sodium–calcium exchanger: a molecular perspective. Annu Rev Physiol 62:111–133. https://doi.org/10.1146/annurev.physiol.62.1.111 CrossRefPubMedGoogle Scholar
Nicoll D, Longoni S, Philipson K (1990) Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2 + exchanger. Science 250:562–565. https://doi.org/10.1126/science.1700476 CrossRefPubMedGoogle Scholar
Li Z, Matsuokas S, Hryshkob LV et al (1994) Cloning of the NCX2 isoform of the plasma membrane Na+–Ca2+ exchanger. J Biol Chem 269:17434–17439PubMedGoogle Scholar
Nicoll DA, Quednau BD, Qui Z et al (1996) Cloning of a third mammalian Na+–Ca2+ exchanger, NCX3. J Biol Chem 271:24914–24921. https://doi.org/10.1074/jbc.271.40.24914 CrossRefPubMedGoogle Scholar
On C, Marshall CR, Perry SF et al (2009) Characterization of zebrafish (Danio rerio) NCX4: a novel NCX with distinct electrophysiological properties. Am J Physiol Physiol 296:C173–C181. https://doi.org/10.1152/ajpcell.00455.2008 CrossRefGoogle Scholar
On C, Marshall CR, Chen N et al (2008) Gene structure evolution of the Na+–Ca2+ exchanger (NCX) family. BMC Evol Biol 8:127. https://doi.org/10.1186/1471-2148-8-127 CrossRefPubMedPubMedCentralGoogle Scholar
Marshall CR, Fox JA, Butland SL et al (2005) Phylogeny of Na +/Ca2 + exchanger (NCX) genes from genomic data identifies new gene duplications and a new family member in fish species. Physiol Genomics 21:161–173. https://doi.org/10.1152/physiolgenomics.00286.2004 CrossRefPubMedGoogle Scholar
Boyman L, Williams GSB, Khananshvili D et al (2013) NCLX: the mitochondrial sodium calcium exchanger. J Mol Cell Cardiol 59:205–213CrossRefGoogle Scholar
Palty R, Silverman WF, Hershfinkel M et al (2010) NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc Natl Acad Sci USA 107:436–441. https://doi.org/10.1073/pnas.0908099107 CrossRefPubMedGoogle Scholar
Palty R, Sekler I (2012) The mitochondrial Na+/Ca2+ exchanger. Cell Calcium 52:9–15CrossRefGoogle Scholar
Linck B, Qiu Z, He Z et al (1998) Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3). Am J Physiol 274:C415–C423. https://doi.org/10.1152/ajpcell.1998.274.2.C415 CrossRefPubMedGoogle Scholar
Ren X, Philipson KD (2013) The topology of the cardiac Na+/Ca2+ exchanger, NCX1. J Mol Cell Cardiol 57:68–71. https://doi.org/10.1016/j.yjmcc.2013.01.010 CrossRefPubMedPubMedCentralGoogle Scholar
Liao J, Li H, Zeng W et al (2012) Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science 335:686–690. https://doi.org/10.1126/science.1215759 CrossRefPubMedGoogle Scholar
Liao J, Marinelli F, Lee C et al (2016) Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger. Nat Struct Mol Biol 23:590–599. https://doi.org/10.1038/nsmb.3230 CrossRefPubMedPubMedCentralGoogle Scholar
Giladi M, Shor R, Lisnyansky M, Khananshvili D (2016) Structure-functional basis of ion transport in sodium–calcium exchanger (NCX) proteins. Int J Mol Sci 17:1949. https://doi.org/10.3390/ijms17111949 CrossRefPubMedCentralGoogle Scholar
Jardetzky O (1966) Simple allosteric model for membrane pumps. Nature 211:969–970. https://doi.org/10.1038/211969a0 CrossRefPubMedGoogle Scholar
Forrest LR, Krämer R, Ziegler C (2011) The structural basis of secondary active transport mechanisms. Biochim Biophys Acta 1807:167–188. https://doi.org/10.1016/j.bbabio.2010.10.014 CrossRefPubMedGoogle Scholar
Khananshvili D (2014) Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions. Pflugers Arch 466:43–60. https://doi.org/10.1007/s00424-013-1405-y CrossRefPubMedGoogle Scholar
Giladi M, Hiller R, Hirsch JA, Khananshvili D (2013) Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX). J Biol Chem 288:23141–23149. https://doi.org/10.1074/jbc.M113.471698 CrossRefPubMedPubMedCentralGoogle Scholar
Ottolia M, Nicoll DA, John S, Philipson KD (2010) Interactions between Ca2+ binding domains of the Na+–Ca2+ exchanger and secondary regulation. Channels 4:159–162. https://doi.org/10.4161/chan.4.3.11386 CrossRefPubMedGoogle Scholar
Giladi M, Lee SY, Ariely Y et al (2017) Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms. Sci Rep 7:993. https://doi.org/10.1038/s41598-017-01102-x CrossRefPubMedPubMedCentralGoogle Scholar
Hilge M, Aelen J, Vuister GW (2006) Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors. Mol Cell 22:15–25. https://doi.org/10.1016/j.molcel.2006.03.008 CrossRefPubMedGoogle Scholar
Besserer GM, Ottolia M, Nicoll DA et al (2007) The second Ca2 + -binding domain of the Na + -Ca 2 + exchanger is essential for regulation: crystal structures and mutational analysis. Proc Natl Acad Sci U S A 104:18467–18472. https://doi.org/10.1073/pnas.0707417104 CrossRefPubMedPubMedCentralGoogle Scholar
Hilgemann DW, Matsuoka S, Nagel GA, Collins A (1992) Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation. J Gen Physiol 100:905–932. https://doi.org/10.1085/jgp.100.6.905 CrossRefPubMedGoogle Scholar
Hilge M (2013) Ca(2 +) regulation in the Na(+)/Ca (2 +) exchanger features a dual electrostatic switch mechanism. Adv Exp Med Biol 961:27–33. https://doi.org/10.1007/978-1-4614-4756-6_3 CrossRefPubMedGoogle Scholar
Hilge M (2012) Ca2+ regulation of ion transport in the Na+/Ca2+ exchanger. J Biol Chem 287:31641–31649. https://doi.org/10.1074/jbc.R112.353573 CrossRefPubMedPubMedCentralGoogle Scholar
Tal I, Kozlovsky T, Brisker D et al (2016) Kinetic and equilibrium properties of regulatory Ca2 + -binding domains in sodium–calcium exchangers 2 and 3. Cell Calcium 59:181–188. https://doi.org/10.1016/J.CECA.2016.01.008 CrossRefPubMedGoogle Scholar
Steinman L, Altmann D, Sansom D et al (1996) Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85:299–302. https://doi.org/10.1016/S0092-8674(00)81107-1 CrossRefPubMedGoogle Scholar
Lee SY, Giladi M, Bohbot H et al (2016) Structure-dynamic basis of splicing-dependent regulation in tissue-specific variants of the sodium-calcium exchanger. FASEB J 30:1356–1366. https://doi.org/10.1096/fj.15-282251 CrossRefPubMedGoogle Scholar
Giladi M, Bohbot H, Buki T et al (2012) Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants. Cell Calcium 51:478–485. https://doi.org/10.1016/j.ceca.2012.04.007 CrossRefPubMedGoogle Scholar
Matsuoka S, Nicoll DA, He Z, Philipson KD (1997) Regulation of cardiac Na(+)-Ca2+ exchanger by the endogenous XIP region. J Gen Physiol 109:273–286. https://doi.org/10.1085/jgp.109.2.273 CrossRefPubMedPubMedCentralGoogle Scholar
Li Z, Nicoll DA, Collins A et al (1991) Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. J Biol Chem 266:1014–1020PubMedGoogle Scholar
Giladi M, Tal I, Khananshvili D (2016) Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins. Front Physiol 7:30. https://doi.org/10.3389/fphys.2016.00030 CrossRefPubMedPubMedCentralGoogle Scholar
Hilgemann DW, Collins A, Matsuoka S (1992) Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP. J Gen Physiol 100:933–961. https://doi.org/10.1085/jgp.100.6.933 CrossRefPubMedGoogle Scholar
Chernysh O, Condrescu M, Reeves JP (2008) Sodium-dependent inactivation of sodium/calcium exchange in transfected Chinese hamster ovary cells. Am J Physiol Cell Physiol 295:C872–C882. https://doi.org/10.1152/ajpcell.00221.2008 CrossRefPubMedPubMedCentralGoogle Scholar
Verkhratsky A, Trebak M, Perocchi F et al (2018) Crosslink between calcium and sodium signalling. Exp Physiol 103:157–169. https://doi.org/10.1113/EP086534 CrossRefPubMedPubMedCentralGoogle Scholar
Michel LYM, Verkaart S, Koopman WJH et al (2014) Function and regulation of the Na+–Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle. J Biol Chem 289:11293–11303. https://doi.org/10.1074/jbc.M113.529388 CrossRefPubMedPubMedCentralGoogle Scholar
DiPolo R, Beaugé L (2006) Sodium/calcium exchanger: influence of metabolic regulation on ion carrier interactions. Physiol Rev 86:155–203CrossRefGoogle Scholar
Berberián G, Bollo M, Montich G et al (2009) A novel lipid binding protein is a factor required for MgATP stimulation of the squid nerve Na+/Ca2+ exchanger. Biochim Biophys Acta 1788:1255–1262. https://doi.org/10.1016/j.bbamem.2008.12.016 CrossRefPubMedGoogle Scholar
Cousido-Siah A, Ayoub D, Berberián G et al (2012) Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger. Acta Crystallogr D 68:1098–1107. https://doi.org/10.1107/S090744491202094X CrossRefPubMedGoogle Scholar
Lariccia V, Amoroso S (2018) Calcium- and ATP-dependent regulation of Na/Ca exchange function in BHK cells: comparison of NCX1 and NCX3 exchangers. Cell Calcium 73:95–103. https://doi.org/10.1016/j.ceca.2018.04.007 CrossRefPubMedGoogle Scholar
Dyck C, Omelchenko A, Elias CL et al (1999) Ionic regulatory properties of brain and kidney splice variants of the NCX1 Na-Ca 2 exchanger. J Gen Physiol 114:701–711. https://doi.org/10.1085/jgp.114.5.701 CrossRefPubMedPubMedCentralGoogle Scholar
Matsuoka S (2004) Forefront of Na+/Ca2+ exchanger studies: regulation kinetics of Na+/Ca2+ exchangers. J Pharmacol Sci 96:12–14. https://doi.org/10.1254/jphs.fmj04002x2 CrossRefPubMedGoogle Scholar
Quednau BD, Nicoll D, Philipson KD (1997) Tissue specificity and alternative splicing of the Na+/Ca2+ exchanger isoforms NCXl, NCX2, and NCX3 in rat. Am J Physiol 272:C1250–C1261. https://doi.org/10.1152/ajpcell.1997.272.4.C1250 CrossRefPubMedGoogle Scholar
Nakasaki Y, Iwamoto T, Hanada H et al (1993) Cloning of the rat aortic smooth muscle Na +/Ca2 + exchanger and tissue-specific expression of isoforms1. J Biochem 114:528–534. https://doi.org/10.1093/oxfordjournals.jbchem.a124211 CrossRefPubMedGoogle Scholar
Rose CR, Ransom BR (1996) Mechanisms of H+ and Na+ changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes. J Neurosci 16:5393–5404CrossRefGoogle Scholar
Nicholas SB, Yang W, Lee SL et al (1998) Alternative promoters and cardiac muscle cell-specific expression of the Na+/Ca2+ exchanger gene. Am J Physiol 274:H217–H232. https://doi.org/10.1152/ajpheart.1998.274.1.H217 CrossRefPubMedGoogle Scholar
Barnes KV, Cheng G, Dawson MM, Menick DR (1997) Cloning of cardiac, kidney, and brain promoters of the feline ncx1 gene. J Biol Chem 272:11510–11517CrossRefGoogle Scholar
Koban MU, Brugh SA, Riordon DR et al (2001) A distant upstream region of the rat multipartite Na(+)-Ca(2+) exchanger NCX1 gene promoter is sufficient to confer cardiac-specific expression. Mech Dev 109:267–279. https://doi.org/10.1016/s0925-4773(01)00548-2 CrossRefPubMedGoogle Scholar
Lee S-L, Yu ASL, Lytton J (1994) Tissue-specific Expression of Na + -Ca2 + exchanger Isoforms. J Biol Chem 269:14849–14852PubMedGoogle Scholar
Yu X-M, Groveman BR, Fang X-Q, Lin S-X (2010) The role of intracellular sodium (Na+) in the regulation of calcium (Ca2+)-mediated signaling and toxicity. Health (Irvine Calif) 02:8–15. https://doi.org/10.4236/health.2010.21002 CrossRefGoogle Scholar
Stadelmann C, Timmler S, Barrantes-Freer A, Simons M (2019) Myelin in the Central Nervous System: structure, Function, and Pathology. Physiol Rev 99:1381–1431. https://doi.org/10.1152/physrev.00031.2018 CrossRefPubMedGoogle Scholar
Pfeiffer S, Warrington AE, Bansal R (1993) The oligodendrocyte and its many cellular processes. Trends Cell Biol 3:191–197. https://doi.org/10.1016/0962-8924(93)90213-K CrossRefPubMedGoogle Scholar
Michalski JP, Kothary R (2015) Oligodendrocytes in a nutshell. Front Cell Neurosci 9:340. https://doi.org/10.3389/fncel.2015.00340 CrossRefPubMedPubMedCentralGoogle Scholar
Elbaz B, Popko B (2019) Molecular control of oligodendrocyte development. Trends Neurosci 42:263–277. https://doi.org/10.1016/j.tins.2019.01.002 CrossRefPubMedGoogle Scholar
Tiane A, Schepers M, Rombaut B et al (2019) From OPC to oligodendrocyte: an epigenetic journey. Cells. https://doi.org/10.3390/cells8101236 CrossRefPubMedPubMedCentralGoogle Scholar
Sock E, Wegner M (2019) Transcriptional control of myelination and remyelination. Glia 67:2153–2165. https://doi.org/10.1002/glia.23636 CrossRefPubMedGoogle Scholar
Wheeler NA, Fuss B (2016) Extracellular cues influencing oligodendrocyte differentiation and (re)myelination. Exp Neurol 283:512–530. https://doi.org/10.1016/j.expneurol.2016.03.019 CrossRefPubMedPubMedCentralGoogle Scholar
Yu L, Colvin RA (1997) Regional differences in expression of transcripts for Na+/Ca2+ exchanger isoforms in rat brain. Mol Brain Res 50:285–292. https://doi.org/10.1016/S0169-328X(97)00202-7 CrossRefPubMedGoogle Scholar
Tong XP, Li XY, Zhou B et al (2009) Ca2 + signaling evoked by activation of Na + channels and Na +/Ca2 + exchangers is required for GABA-induced NG2 cell migration. J Cell Biol 186:113–128. https://doi.org/10.1083/jcb.200811071 CrossRefPubMedPubMedCentralGoogle Scholar
Steffensen I, Waxman SG, Mills L, Stys PK (1997) Immunolocalization of the Na+-Ca2+ exchanger in mammalian myelinated axons. Brain Res 776:1–9. https://doi.org/10.1016/S0006-8993(97)00868-8 CrossRefPubMedGoogle Scholar
Boscia F, D'avanzo C, Pannaccione A et al (2012) Silencing or knocking out the Na +/Ca2 + exchanger-3 (NCX3) impairs oligodendrocyte differentiation. Cell Death Differ 19:562–572. https://doi.org/10.1038/cdd.2011.125 CrossRefPubMedGoogle Scholar
Boscia F, D'Avanzo C, Pannaccione A et al (2013) New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes. Adv Exp Med Biol 961:307–316. https://doi.org/10.1007/978-1-4614-4756-6_26 CrossRefPubMedGoogle Scholar
Simpson PB, Armstrong RC (1999) Intracellular signals and cytoskeletal elements involved in oligodendrocyte progenitor migration. Glia 26:22–35CrossRefGoogle Scholar
Paez PM, Fulton D, Colwell CS, Campagnoni AT (2009) Voltage-operated Ca2+ and Na+ channels in the oligodendrocyte lineage. J Neurosci Res 87:3259–3266. https://doi.org/10.1002/jnr.21938 CrossRefPubMedGoogle Scholar
Habermacher C, Angulo MC, Benamer N (2019) Glutamate versus GABA in neuron-oligodendroglia communication. Glia 67:2092–2106. https://doi.org/10.1002/glia.23618 CrossRefPubMedGoogle Scholar
Friess M, Hammann J, Unichenko P et al (2016) Intracellular ion signaling influences myelin basic protein synthesis in oligodendrocyte precursor cells. Cell Calcium 60:322–330. https://doi.org/10.1016/j.ceca.2016.06.009 CrossRefPubMedGoogle Scholar
Hammann J, Bassetti D, White R et al (2018) α2 isoform of Na+, K+-ATPase via Na+, Ca2+ exchanger modulates myelin basic protein synthesis in oligodendrocyte lineage cells in vitro. Cell Calcium 73:1–10. https://doi.org/10.1016/j.ceca.2018.03.003 CrossRefPubMedGoogle Scholar
Thakurela S, Garding A, Jung RB et al (2016) The transcriptome of mouse central nervous system myelin. Sci Rep 6:25828. https://doi.org/10.1038/srep25828 CrossRefPubMedPubMedCentralGoogle Scholar
Martinez-Lozada Z, Waggener CT, Kim K et al (2014) Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain. Glia 62:1543–1558. https://doi.org/10.1002/glia.22699 CrossRefPubMedPubMedCentralGoogle Scholar
Suárez-Pozos E, Thomason EJ, Fuss B (2019) Glutamate transporters: expression and function in oligodendrocytes. Neurochem Res. https://doi.org/10.1007/s11064-018-02708-x CrossRefPubMedGoogle Scholar
Martínez-Lozada Z, Hernández-Kelly LC, Aguilera J et al (2011) Signaling through EAAT-1/GLAST in cultured Bergmann glia cells. Neurochem Int 59:871–879. https://doi.org/10.1016/j.neuint.2011.07.015 CrossRefPubMedGoogle Scholar
Iwamoto T, Kita S, Shigekawa M (2002) Functional analysis of Na+/Ca2+ exchanger using novel drugs and genetically engineered mice. Nihon Yakurigaku Zasshi 120:91P–93PCrossRefGoogle Scholar
Iwamoto T, Inoue Y, Ito K et al (2004) The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]- thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol Pharmacol 66:45–55. https://doi.org/10.1124/mol.66.1.45 CrossRefPubMedGoogle Scholar
Gong XQ, Frandsen A, Lu WY et al (2005) D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons. Br J Pharmacol 145:449–459. https://doi.org/10.1038/sj.bjp.0706199 CrossRefPubMedPubMedCentralGoogle Scholar
Sugiyama H, Ito I, Watanabe M (1989) Glutamate receptor subtypes may be classified into two major categories: a study on Xenopus oocytes injected with rat brain mRNA. Neuron 3:129–132. https://doi.org/10.1016/0896-6273(89)90121-9 CrossRefPubMedGoogle Scholar
Bender AS, Woodbury DM, White HS (1997) The rapid L- and D-aspartate uptake in cultured astrocytes. Neurochem Res 22:721–726. https://doi.org/10.1023/a:1027358211472 CrossRefPubMedGoogle Scholar
de Rosa V, Secondo A, Pannaccione A et al (2019) d-Aspartate treatment attenuates myelin damage and stimulates myelin repair. EMBO Mol Med 11:e9278. https://doi.org/10.15252/emmm.201809278 CrossRefPubMedGoogle Scholar
Kukley M, Capetillo-Zarate E, Dietrich D (2007) Vesicular glutamate release from axons in white matter. Nat Neurosci 10:311–320. https://doi.org/10.1038/nn1850 CrossRefPubMedGoogle Scholar
Ziskin JL, Nishiyama A, Rubio M et al (2007) Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci 10:321–330. https://doi.org/10.1038/nn1854 CrossRefPubMedPubMedCentralGoogle Scholar
Wake H, Lee PR, Fields RD (2011) Control of local protein synthesis…background. Science 333:1647–1652. https://doi.org/10.1126/science.1206998 CrossRefPubMedPubMedCentralGoogle Scholar
Foster AY, Bujalka H, Emery B (2019) Axoglial interactions in myelin plasticity: evaluating the relationship between neuronal activity and oligodendrocyte dynamics. Glia 67:2038–2049. https://doi.org/10.1002/glia.23629 CrossRefPubMedGoogle Scholar
Monje M (2018) Myelin plasticity and nervous system function. Annu Rev Neurosci 41:61–76. https://doi.org/10.1146/annurev-neuro-080317-061853 CrossRefPubMedGoogle Scholar
Chorghay Z, Káradóttir RT, Ruthazer ES (2018) White matter plasticity keeps the brain in tune: axons conduct while glia wrap. Front Cell Neurosci 12:428. https://doi.org/10.3389/fncel.2018.00428 CrossRefPubMedPubMedCentralGoogle Scholar
Bechler ME, Swire M, Ffrench-Constant C (2018) Intrinsic and adaptive myelination-A sequential mechanism for smart wiring in the brain. Dev Neurobiol 78:68–79. https://doi.org/10.1002/dneu.22518 CrossRefPubMedGoogle Scholar
Back SA, Luo NL, Borenstein NS et al (2001) Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. J Neurosci 21:1302–1312. https://doi.org/10.1523/jneurosci.21-04-01302.2001 CrossRefPubMedPubMedCentralGoogle Scholar
Cai Q, Ma T, Tian Y et al (2018) Catalpol inhibits ischemia-induced premyelinating oligodendrocyte damage through regulation of intercellular calcium homeostasis via Na+/Ca2+ exchanger 3. Int J Mol Sci. https://doi.org/10.3390/ijms19071925 CrossRefPubMedPubMedCentralGoogle Scholar
Ma T, Wu X, Cai Q et al (2015) Lead poisoning disturbs oligodendrocytes differentiation involved in decreased expression of NCX3 inducing intracellular calcium overload. Int J Mol Sci 16:19096–19110. https://doi.org/10.3390/ijms160819096 CrossRefPubMedPubMedCentralGoogle Scholar
Deng W, McKinnon RD, Poretz RD (2001) Lead exposure delays the differentiation of oligodendroglial progenitors in vitro. Toxicol Appl Pharmacol 174:235–244. https://doi.org/10.1006/TAAP.2001.9219 CrossRefPubMedGoogle Scholar
Pignataro G, Cuomo O, Vinciguerra A et al (2013) NCX as a key player in the neuroprotection exerted by ischemic preconditioning and postconditioning. Adv Exp Med Miol 961:223–240. https://doi.org/10.1007/978-1-4614-4756-6_19 CrossRefGoogle Scholar
Pignataro G, Gala R, Cuomo O et al (2004) Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke 35:2566–2570. https://doi.org/10.1161/01.STR.0000143730.29964.93 CrossRefPubMedGoogle Scholar
Gerkau NJ, Rakers C, Durry S et al (2018) Reverse NCX attenuates cellular sodium loading in metabolically compromised cortex. Cereb Cortex 28:4264–4280. https://doi.org/10.1093/cercor/bhx280 CrossRefPubMedGoogle Scholar
Chen H, Kintner DB, Jones M et al (2007) AMPA-mediated excitotoxicity in oligodendrocytes: role for Na+-K+-Cl—co-transport and reversal of Na+/Ca2+ exchanger. J Neurochem 102:1783–1795. https://doi.org/10.1111/j.1471-4159.2007.04638.x CrossRefPubMedGoogle Scholar
Stover JF, Pleines UE, Morganti-Kossmann MC et al (1997) Neurotransmitters in cerebrospinal fluid reflect pathological activity. Eur J Clin Invest 27:1038–1043. https://doi.org/10.1046/j.1365-2362.1997.2250774.x CrossRefPubMedGoogle Scholar
Macrez R, Stys PK, Vivien D et al (2016) Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. Lancet Neurol 15:1089–1102. https://doi.org/10.1016/S1474-4422(16)30165-X CrossRefPubMedGoogle Scholar
Newcombe J, Uddin A, Dove R et al (2008) Glutamate receptor expression in multiple sclerosis lesions. Brain Pathol 18:52–61. https://doi.org/10.1111/j.1750-3639.2007.00101.x CrossRefPubMedGoogle Scholar
Follett PL, Deng W, Dai W et al (2004) Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. J Neurosci 24:4412–4420. https://doi.org/10.1523/JNEUROSCI.0477-04.2004 CrossRefPubMedPubMedCentralGoogle Scholar
McCracken E, Fowler JH, Dewar D et al (2002) Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502. J Cereb Blood Flow Metab 22:1090–1097. https://doi.org/10.1097/00004647-200209000-00006 CrossRefPubMedGoogle Scholar
Park E, Velumian AA, Fehlings MG (2004) The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma 21:754–774. https://doi.org/10.1089/0897715041269641 CrossRefPubMedGoogle Scholar
Rosenberg LJ, Teng YD, Wrathall JR (1999) 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline reduces glial loss and acute white matter pathology after experimental spinal cord contusion. J Neurosci 19:464–475CrossRefGoogle Scholar
Wosik K, Ruffini F, Almazan G et al (2004) Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injury. Brain 127:2636–2648. https://doi.org/10.1093/brain/awh302 CrossRefPubMedGoogle Scholar
Itoh T, Beesley J, Itoh A et al (2002) AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytes. J Neurochem 81:390–402. https://doi.org/10.1046/j.1471-4159.2002.00866.x CrossRefPubMedGoogle Scholar
Ceprian M, Fulton D (2019) Glial cell AMPA receptors in nervous system health, injury and disease. Int J Mol Sci. https://doi.org/10.3390/ijms20102450 CrossRefPubMedPubMedCentralGoogle Scholar
Fan X, Xiong Y, Wang Y (2019) A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications. Front Med 13:531–539. https://doi.org/10.1007/s11684-019-0700-1 CrossRefPubMedGoogle Scholar
Hsu LS, Chou WY, Chueh SH (1995) Evidence for a Na+/Ca2+ exchanger in neuroblastoma x glioma hybrid NG108-15 cells. Biochem J 309:445–452. https://doi.org/10.1042/bj3090445 CrossRefPubMedPubMedCentralGoogle Scholar
Amoroso S, De Maio M, Russo GM et al (1997) Pharmacological evidence that the activation of the Na(+)-Ca2+ exchanger protects C6 glioma cells during chemical hypoxia. Br J Pharmacol 121:303–309. https://doi.org/10.1038/sj.bjp.0701092 CrossRefPubMedPubMedCentralGoogle Scholar
Rodrigues T, Estevez GNN, Tersariol ILDS (2019) Na +/Ca2 + exchangers: unexploited opportunities for cancer therapy? Biochem Pharmacol 163:357–361. https://doi.org/10.1016/j.bcp.2019.02.032 CrossRefPubMedGoogle Scholar
Hu H-J, Wang S-S, Wang Y-X et al (2019) Blockade of the forward Na+/Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+-mediated cell death. Br J Pharmacol 176:2691–2707. https://doi.org/10.1111/bph.14692 CrossRefPubMedPubMedCentralGoogle Scholar
Marques S, Zeisel A, Codeluppi S et al (2016) Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system. Science 352:1326–1329. https://doi.org/10.1126/science.aaf6463 CrossRefPubMedPubMedCentralGoogle Scholar
Foerster S, Hill MFE, Franklin RJM (2019) Diversity in the oligodendrocyte lineage: plasticity or heterogeneity? Glia 67:1797–1805. https://doi.org/10.1002/glia.23607 CrossRefPubMedGoogle Scholar
Spitzer SO, Sitnikov S, Kamen Y et al (2019) Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age. Neuron 101:459.e5–471.e5. https://doi.org/10.1016/j.neuron.2018.12.020 CrossRefGoogle Scholar
Jäkel S, Agirre E, Mendanha Falcão A et al (2019) Altered human oligodendrocyte heterogeneity in multiple sclerosis. Nature 566:543–547. https://doi.org/10.1038/s41586-019-0903-2 CrossRefPubMedPubMedCentralGoogle Scholar
Watanabe Y (2019) Cardiac Na+/Ca2+ exchange stimulators among cardioprotective drugs. J Physiol Sci. https://doi.org/10.1007/s12576-019-00721-5 CrossRefPubMedGoogle Scholar
Song S, Luo L, Sun B, Sun D (2019) Roles of glial ion transporters in brain diseases. Glia. https://doi.org/10.1002/glia.23699 CrossRefPubMedGoogle Scholar
1.Department of Anatomy and NeurobiologyVirginia Commonwealth University School of MedicineRichmondUSA
2.Departamento de ToxicologíaCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalCiudad de MéxicoMexico
Spencer, S.A., Suárez-Pozos, E., Escalante, M. et al. Neurochem Res (2020). https://doi.org/10.1007/s11064-019-02949-4


text:
Q: TTStyledTextLabel - unrecognized selector exception I am using the 2.x compatible branch of Three20 library. I want to display a URL and am using the TTStyledTextLabel for this purpose.
However when trying to use it, I get an exception
*** Terminating app due to uncaught exception 'NSInvalidArgumentException', reason: '*** -[TTStyledTextLabel width]: unrecognized selector sent to instance 0x4bc440'

This is how I am using the TTStyledTextLabel object (inside a custom tableviewcell)
TTStyledTextLabel *textLabel = (TTStyledTextLabel *)[cell.contentView viewWithTag:2];
[textLabel setText:[TTStyledText textFromXHTML:myFormattedText lineBreaks:YES urls:YES]];

Can someone please tell me why this exception occurs?
Thanks.

A: The width member is added by the category UIViewAdditions on UIView. Can you check that it's there in this release?

A: I had the same problem, caused due to the Three20 UIViewAdditions categories not being applied.
Check that you have added the -ObjC flag to your "Other Linker Flags" build. I had it missing.
There is more information on these categories not being applied on a Three20's google groups thread

redpajama_set_name: RedPajamaStackExchange


We believe the best solutions go beyond IT. They support your vision and business strategy like a trusted partner. And yes, it's as liberating as it sounds. Welcome to what's possible.
Enjoy the liberation that happens when you can manage infrastructure, data, and voice from anywhere.
It is like any relationship.
When it's good, it just feels right.
We believe your success is our success, and we're not above the occasional celebratory shuffle.
We love what we do, and we're not the only ones who feel that way.


text:
Maternity matters
Positive Parenting,
November 21, 2019 . Baca dalam BM
Juggling a career and family can be tough, especially for newly-christened working mums. But young Malaysian parents, caring employers and extended families are joining forces to create success stories.
It's meant to be such a special time in your life, when you and your partner decide to welcome a baby into the world, and embark on the journey of becoming a family together. However, the trip is often littered with discussions (sometimes arguments!) and life-changing decisions about careers, living arrangements and budgets.
Working women, in particular, have to weigh the consequences of having a baby against forging ahead in their careers. Pregnancies often force families into traditional gender roles where the husband concentrates more on paid work and the wife sacrifices her career to look after the children at home, ultimately putting women at a disadvantage when it comes to gender equality in the workplace.
Progressive parental leave policies, such as those in Scandinavian countries like Finland, Germany and Iceland, can make the transition to parenthood more equitable, splitting the responsibilities between both parents regardless of gender. However, in Malaysia, women still bear the bulk of the burden of caring for the family, more so because the law was designed that way six decades ago and has yet to go through major reforms.
Under Maternity Protection Eligibility in the Employment Act 1955 in Malaysia, mums are eligible to 60 consecutive days of maternity leave, and each female employee is entitled to paid maternity leave for up to five children. Meanwhile, fathers in the private sector are not legally entitled to any paternity leave, while fathers in the public sector get seven days of paid paternity leave. The Human Resources Ministry earlier this year proposed amendments to the Employment Act suggesting the inclusion of three days of paid paternity leave for those in the private sector.
In June, The Star Online reported that Malaysia's female labour force participation was only at 55.6% – one of the lowest in South-East Asia – compared to 80.7% for that of men, as of 2018.
What's more is that many women feel unsupported when they eventually try to return to the workforce after their maternity leave expires. There usually isn't any formal structure of support for these women who have to adjust to their new role as "working mums". The onus is almost always on the mother to adjust her baby's feeding and sleeping schedules, and to figure out how to get to work and home on time (cook, clean and ferry the other children to school/daycare), as well as how they will continue breastfeeding (where and when to pump breast milk, how to store it) all while keeping up with their peers at work! That's no small feat! Those who are self-employed are not spared from these challenges.
Ooi See Bee from Kuching, Sarawak, who runs an ice-cream food truck, says that breastfeeding was challenging once she resumed working after her confinement.
The mother of two says: "The challenge was making time to nurse my baby. My job required me to work outdoors, hence looking for a place to express milk was really hard and storing it was an added challenge! Most times, I would do it in the car with all shades up and I carried my ice bag around with me."
Breast milk supply has been known to drop when one returns to the workforce, probably because the work environment is not as conducive as home.
Ooi See Bee with husband Dennis Sim and their beautiful children.
Twenty years ago, many offices did not have a nursing station, so women were forced to sit in bathrooms or storerooms when they needed to express their milk. Pumping was also considered disruptive to work routines and would eat into one's lunch or break times, and not put you in the best light with your co-workers and bosses! However, things are changing for the better, and many young women find their peers and management growing in their acceptance of working mothers' need for flexible working hours, cutting them some slack.
Journalist Nasa Maria Entaban from Petaling Jaya shares that her bosses were completely supportive of her new role in life as a mother.
"No one ever gave me grief about taking time off to take my kids for their vaccinations or to be with them when they were ill, and I was rarely assigned events after hours until my (first) child was older and we hired a live-in helper," says the 37-year-old who has two daughters, a six-year-old and an eight-month-old baby.
Nasa and her husband Davin Fernandez, with their adorable daughters Dani Karina, 6 years, and Nuri Marlena, 7 months.
Nasa's workplace at Menara Star has a nursing mothers' room where mothers are able to comfortably pump in private and store milk in a safe and clean environment, and are allowed time to pump as many times a day as they need to.
Nasa adds, however, that her challenge was (and still is) figuring out when she can commit more time to build her career and take on more responsibility. She says: "Even with my hours being forgiving and having my weekends off, I still feel like I am stretched thin with trying to juggle raising children and thinking about my career, let alone my spousal duties!"
So, can employers do more to level the playing field for working moms, and new mothers in particular? Nasa feels that there should be more understanding of the importance of a father's role in caring for children.
"Don't perpetuate the stereotype that parenting is 90% a woman's job. Give dads the chance to take their kids to the doctor and so on. If most of the parenting continues to be left to the mother, women will continue to be left behind in the workforce.
"For new mums, set up a daycare centre in the same building so that mothers can return to work, assured that their baby is just a floor or two away. More importantly if they are breastfeeding this will enable them to maintain their supply which often drops when breastfeeding mothers return to full time work. Or, offer subsidies for daycare centres near the workplace (some multinationals in KL offer this already). For working mums, make working from home an option. Don't punish parents for wanting to raise the next generation of adults."
Indeed, even at companies that offer formal flexible work policies for mothers, employees are often too afraid to take advantage of the benefit for fear they may be earmarked as "unambitious" or "distracted" and placed in less-demanding, lower-paying positions. Meanwhile, those who decide to take a longer break from work may find it just as disconcerting. Letting go of a career, even temporarily, can create anxiety and many new mums feel a little bit lost with the sudden displacement of their careers.
However, if you have a sound foundation with your partner and decide from the get go how connected you want to be with your family, as well as your career, then you can set your priorities ahead of time, and you might be able to advance successfully as both mother and career woman.
Siti Hajar with her husband, Kushairy Shoib, and son, Qaiser Kamal.
Siti Hajar Abdul Rahman, 39, from Petaling Jaya, was working in Corporate Communications when she gave birth to her son, who is now four.
"Initially I took maternity leave but eventually I had to resign as I felt three months was not enough for me to be with my son and I wanted to breastfeed for the first six months. I was also not prepared to let someone else care for him. I ended up staying at home for six months before going back to work as a consultant, and this allowed me to work two days a week with flexible hours," Hajar shares.
"Six months was good for me. Enough time not only to get into a good routine but it gave me time and the ability to breastfeed exclusively. It was also long enough that by the time I did decide to go back to work, I couldn't wait! My husband played a really important role in the initial months and even to this day. After I had my son, I actually suffered severe pelvic pains. I had to go for physiotherapy every other day for three months before I was healed. During that time, my husband's presence helped tremendously to offload some of the burden of caring for a newborn while I underwent recovery."
For in depth interviews with these mums, go to Working Women: Mums and Maternity Leave
Real Life Real People
Parenting: From Kids to the Nation
Raising 'Green' Kids
Daphne's Style of Modern Parenting
Feature Interview: Prof Muhaya


text:
20 Years Later, 'Almost Famous' Is The Best Kind Of Feel-Good Movie
Kate Hudson has a line in "Almost Famous" that is cheesy, overwrought and perfect. I think about it often. Her character, aptly named Penny Lane, says to fledgling 1970s rock journalist William Miller (Patrick Fugit) while driving around San Diego one night, "I always tell the girls, 'Never take it seriously.' If you never take it seriously, you never get hurt. If you never get hurt, you always have fun. And if you ever get lonely, just go to the record store and visit your friends." It's that last sentence, which Hudson protracts so it sounds wistful, that gets me. No matter how many personal foibles you'll encounter — and there will be many — you can always find restoration in the music you love, especially as a young adult still discovering the world.
That's what "Almost Famous" is about, at least on the surface: music. The people who make it, the people who worship it, the people who fail to appreciate what it can do for our souls. Cameron Crowe was one of America's hottest directors when the movie opened 20 years ago, on Sept. 13, 2000. He'd made "Say Anything," "Singles" and "Jerry Maguire," but this would be his masterpiece. A coming-of-age jewel that channels Crowe's days as a youthful, obsessive Rolling Stone writer, "Famous" took Hollywood's penchant for palatable crowd-pleasers and gave it an intelligence not always seen in such flagrantly sentimental filmmaking.
Google "feel-good cinema" and you'll find more lists than you care to read, including many published this year in an apparent effort to provide coronavirus uplift. These inventories often contain the same lighthearted go-tos, things like "Legally Blonde," "Grease," "Sister Act" and "Groundhog Day." Worthwhile movies, sure, but our accepted definition of "feel-good" clearly has limits. Does no one swoon when they watch "Alien"? It's so well-made, and Sigourney Weaver survives! Ditto Shelley Duvall in "The Shining." What about Spike Lee's "Crooklyn," a comedy that feels achingly human in the way it addresses death? And yeah, maybe you'll tear up at the end of "Eternal Sunshine of the Spotless Mind" or "The Umbrellas of Cherbourg" or "Lost in Translation," but what feels better than a quality cry?
Dreamworks Pictures/Globe Photos/ZUMAPRESS/Alamy
Patrick Fugit and Kate Hudson in "Almost Famous."
I'm being a little facetious here, but I do wish we had more space within the confines of "feel-good" to include art that isn't quite so bubbly. When I think of the ideal feel-good movie, I think of "Almost Famous," a film that offers grand, bittersweet ideas about life without becoming cloying or mistaking austerity for importance. It has a satisfying ending but still manages not to soak the underlying heft in syrup. At the time, that was Crowe's specialty. His sensibilities have faltered in the intervening years (see: "Elizabethtown" and "Aloha"), and Hollywood's major studios no longer prioritize the original, moderately budgeted ensemble projects for which Crowe is known. But that makes "Almost Famous" special. Twenty years later, it's more "feel-good" than ever.
Crowe based his protagonists on real people. Penny Lane was inspired by a self-appointed music promoter who transcended the clichés of a '70s groupie; earnest William Miller was basically Crowe himself; William's strict mother (Frances McDormand) mirrored Crowe's own upbringing; the musicians in the fictional band with whom William embeds himself were drawn from Gregg Allman, Robert Plant and Jimmy Page. (Peter Frampton and Crowe's then-wife Nancy Wilson also led a boot camp for the actors before production began.) That explains the movie's verisimilitude, but its enchantment stems instead from the way "Almost Famous" plays like a fairy tale, at once grounded and mystical. No one can truly drown their problems in music, and even fewer people become 15-year-old rock journalists — but it's nice to pretend.
The fairy tale lies within William's ambitions. His older sister (Zooey Deschanel, taking the role in which Hudson was initially cast) fled their mother's restrictive home, leaving behind a vinyl stash that introduces William to The Beach Boys, Jimi Hendrix, Joni Mitchell, Bob Dylan and The Who. "Look under your bed, it'll set you free," she tells him in another of those cheesy, perfect lines before cruising down their suburban street one last time. She's right: William finds in those records a liberation he didn't know he needed, eventually turning his newfound cultural appreciation into a thrifty freelance career.
William's evolving relationships with Penny Lane and other industry players — particularly fellow hanger-on Sapphire (Fairuza Balk), golden-god guitarist Russell Hammond (Billy Crudup) and mentor Lester Bangs (Philip Seymour Hoffman) — are what really undergird the film. He was an outcast in school, too smart to fit in and too shielded to relate to his peers. Through Penny and the rest, William discovers the textures of a world beyond his domestic tutelage, one where the glamorous rebellion of rock 'n' roll is tainted by potential drug overdoses, messy romantic entanglements and near-fatal airplane rides. It's dark stuff, but filtered through William's starry eyes, it assumes a philosophic quality: Nothing in life is as it seems, and the truth lies somewhere in the middle, if you're willing to look for it.
Evan Agostini via Getty Images
Frances McDormand, Philip Seymour Hoffman, Kate Hudson, Patrick Fugit, Cameron Crowe, Jimmy Fallon, Billy Crudup and Jason Lee at a party celebrating "Almost Famous" in 2000.
Turns out it's the professionals learning from the teenager, though, whom they call "the enemy" because he seeks to write a warts-and-all profile. The rock idols are out there betraying one another, picking unnecessary fights, devaluing the women who revere them and taking their privileged stations for granted. William could go the same route, succumbing to hedonism. But he doesn't. He writes the unvarnished story, and he doesn't need some Faustian bargain to do it. In the end, when Russell visits him at home, William is still sweet and uncorrupted, if no longer naive. The stars became his friends, more or less, but William's ability to remove his rose-colored goggles signals a newfound adulthood. That makes him as complex a protagonist as any character twice his age, and it wisely makes sure not to punish Mom for imparting the lessons that kept him whole.
"Almost Famous" wasn't a runaway hit upon arrival; in wide release, "Urban Legends: The Final Cut" and a re-release of 1973's "The Exorcist" won the box office. Worldwide grosses totaled $47.4 million, less than it cost to make. The fact that it has achieved such beloved status over the past 20 years shows how good the story makes us feel. It is nourishment, amusement and sophistication wrapped up in one. The New York Times recently wrote an oral history of Russell's roof-diving acid trip. The podcast "Origins" recruited Crowe, Fugit, Hudson and others for a fantastic oral history spanning the entire project. In a 2003 episode of "Gilmore Girls," love interest Jess (Milo Ventimiglia) claims to be "addicted" to the movie. It has since been referenced in "Weeds," "The Simpsons," "Orange Is the New Black," "Entourage" and "Psych."
In an unexpected way, Penny's promise to William came true, though I'm not convinced she believed most of what she was saying. The movie makes clear that Penny takes the landscape she inhabits very seriously, no matter the fun she has. Her heart is nothing if not broken. But she knows enough to know there is respite from heartbreak, that you can throw on some tunes — or "Almost Famous," perhaps — and find just a little bit of catharsis.
Illustration: Damon Dahlen/HuffPost; Photos: Columbia Pictures/Getty/Alamy.
Kevin Dobson, 'Knots Landing' And 'Kojak' Actor, Dies At 77


text:
Q: Place elements in custom places in Android I want to make an application that draws a layout with some background and then adds an Imageview and then adds some Image buttons on the Imageview in a specific places (x, y).
Can anyone tell me how to do that or a simple tutorial that may help me as I'm new to Android?

A: Maybe reading Android documentation about GUIs is a good first step...

A: To place an element at a specific position, use an AbsoluteLayout


Though it is most often attributed to the great sports writer Red Smith, no one knows for sure who first bled this great insight—"Writing is easy. You just open a vein and bleed." Like all great metaphors, this one invites us to slow down and examine its many facets.
OK, finally finally. The moment your blood stops flowing you die. With writing it is the same. Write as often as blood is flowing through you. Or to be more clear—write always. On the other hand, know when to stop.


Faith Press, 1962. Faith Press, 1962. Hardcover. Used; Good. Hardcover; English language; No jacket; 24mo - over 5" - 5.75" tall; 1962 first thus, pictorial boards no dust jacket, 158 pages good all-round condition. Your book will be securely packed and promptly dispatched from our UK warehouse. All international orders are sent Royal Mail airmail.