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ABC Fall Pilot Review: Malibu Country - Premieres November 2
Malibu Country - Fridays 8:30PM ET/PT on ABC
Premieres Friday, November 2, 2012 at 8:30PM ET/PT
Country music superstar/actress Reba McEntire (Reba, Tremors) returns to television as a wife and mother whose world is turned upside-down when she discovers that her country music legend husband has a cheatin' heart.
On her way to becoming a country star herself, Reba put her career on hold to raise a family. Husband Bobby always emphasized family values in his music, but with the very public discovery of his numerous affairs, Reba decides to not stand by her man. Now, with a divorce pending, Reba packs up her sharp-tongued southern mother, Lillie Mae (Lily Tomlin, Laugh-In, Damages, Desperate Housewives, The West Wing, Nine to Five, Nashville), and her two kids and U-Hauls it straight to sunny California to begin a new chapter in life. Leaving Nashville in the rear view mirror, they start over at their Malibu residence -- the last remaining asset they have, and Bobby's former secret love nest.
Once the most popular boy in his Nashville high school, Reba's teenaged son, Cash, finds himself feeling positively average compared to the good looking, affluent Malibu boys -- a fate worse than death! On the other hand, Reba's teen daughter, June (Juliette Angelo, New Year's Eve), never really fit in with her peers. In Malibu she blends in perfectly and finds a new best friend in Sage, an openly gay neighborhood boy who embraces his sexuality. Tough-as-nails mom Lillie Mae discovers the serenity of Southern California living and fully embraces her new laid-back, relaxed lifestyle. But Reba learns that relocating to Malibu is going to be quite a challenge to her traditional southern values. The West Coast seems like the polar opposite of Music City, and she feels like an outsider. Her gregarious and very liberal new neighbor and Sage's stepmother, Kim (Sara Rue, Less Than Perfect), doesn't have many friends and immediately attaches herself to Reba, enthusiastically offering to mentor her in becoming a little less country a bit more California cool.
When Reba discovers that trying to revive her career is going to be an uphill battle, she befriends Geoffrey (Jai Rodriguez, Queer Eye for the Straight Guy), the assistant to her new music agent. With his help and unorthodox methods, she might yet have a chance to become a chart topper. Still, in the end it's family that matters most to Reba, as each member of hers learns to view this new Malibu lifestyle as a chance to begin anew.
• Reba McEntire as Reba
* Lily Tomlin as Lillie Mae
* Sara Rue as Kim
* Justin Prentice as Cash
* Juliette Angelo as June
* Jai Rodriguez as Geoffrey
On television Reba McEntire (Reba) starred for six seasons in the hit series Reba, as well as the television movies The Gambler Returns: The Luck of the Draw, opposite Kenny Rogers, The Man from Left Field, with Burt Reynolds, Is There Life Out There?, Buffalo Girls, opposite Anjelica Huston and Melanie Griffith, Forever Love and Secret of Giving. On Broadway she starred in the musical Annie Get Your Gun and as Ensign Nellie Forbush in the musical South Pacific, which was filmed and aired as an episode of Great Performances. On the big screen she starred in the science fiction classic Tremors, alongside Kevin Bacon, North, opposite Elijah Wood, Jason Alexander and Julia Louis-Dreyfus, The Little Rascals and One Night at McCools, co-starring Liv Tyler. She has also lent her voice to the film Charlotte's Web as Betsy the Cow, Fox and the Hound 2 as Dixie and the animated television series Hercules as Artemis.
Lily Tomlin (Lillie Mae) made her television debut in 1966 on The Garry Moore Show and then made several memorable appearances on The Merv Griffin Show, which led to a move to California, where she appeared as a regular on Music Scene. In December 1969 she joined the cast of the top-rated Laugh-In and immediately rose to national prominence with her characterizations of Ernestine, the irascible telephone operator, and Edith Ann, the devilish six-year-old. When Laugh-In left the air, Tomlin went on to co-write, with Jane Wagner, and star in six comedy television specials -- The Lily Tomlin Show (1973), Lily (1973), Lily Tomlin (1975), Lily: Sold Out (1981) and Lily for President? (1982), for which she won three Emmy awards and a Writers Guild of America award. Tomlin also starred in the HBO special about the AIDS epidemic, And the Band Played On (1993). She has guest starred on such television shows as Homicide: Life on the Street, The X-Files and Will & Grace, and played the boss on CBS' Murphy Brown. She is also heard as the voice of science teacher Ms. Frizzle on the popular children's animated series, The Magic School Bus, for which she was awarded an Emmy.
In 2002 Tomlin joined the cast of the hit NBC series, The West Wing, playing President Bartlett's assistant, Debbie Fiderer -- a role for which she received a 2003 Screen Actors Guild nomination for Best Actress in a Drama Series. In the past few years, Tomlin has made several guest appearances on Desperate Housewives, NCIS and Eastbound and Down, and guest starred in the acclaimed FX series, Damages, in the Emmy-nominated role of a matriarch of a wealthy New York family accused of financial fraud. Tomlin can also be seen on Showtime's series, Web Therapy, as Lisa Kudrow's narcissistic mother.
Sara Rue's (Kim) acting career began at age nine when she was cast as Kevin Spacey's daughter and Burt Lancaster's granddaughter in the film Rocket Gibraltar. Shortly thereafter she won critical acclaim for her television series debut in the comedy Grand. Since then she has appeared as a series regular on various shows, including Phenom, Minor Adjustments, Zoe, Duncan, Jack & Jane, Popular and Eastwick. She is best known for her starring role in ABC's Less Than Perfect. Following that, Chuck Lorre added Rue for recurring appearances on Two and a Half Men and The Big Bang Theory. For the past two years she has had a recurring role on Rules of Engagement as Brenda, Patrick Warburton's lesbian best friend and surrogate.
Justin Prentice (Cash) has made guest appearances on Criminal Minds, Melissa & Joey, The Middle, Victorious, iCarly and Suburgatory. His film credits include Terri and Me Again.
Juliette Angelo (June) made her Broadway debut at age eight in How the Grinch Stole Christmas. From there she joined the original Broadway cast of Billy Elliot, which won a Tony Award for Best Musical, then continued in the role of Jane Banks in Disney's Mary Poppins. In film, Juliette has had roles in Gary Marshall's New Years Eve.
Jai Rodriguez (Geoffrey) has achieved great success as an actor on stage and screen, and as host of one of television's most memorable reality series. His most notable role to-date was his stint as host of Bravo's Emmy Award-winning reality program Queer Eye for the Straight Guy. Other hosting credits include Animal Planet's Groomer Has It, co-host of Ultimate Style and the pre-show of the 2009 American Music Awards. Rodriguez served as co-creator and co-executive producer of the Logo's Bad Sex and host/producer of SiTV's Styleyes. In feature film Rodriguez was featured in the role of "Sabu" on the acclaimed 2005 big screen version of The Producers. Guest starring credits in television series as Bones, Harry's Law and the daytime drama Days of Our Lives. He also appears in the smash hit music video Telephone, starring Lady Gaga and Beyoncé.
Pilot Episode:
"Pilot" (November 2, 8:30PM) - In the premiere episode, "Pilot," Reba very publicly discovers that her country music legend husband, Bobby Gallagher, has been cheating on her. Determined to get a fresh start and perhaps revive her own country music career, Reba packs up her sharp-tongued mother and two kids and drives cross country to live in Bobby's Malibu beach-front party pad. Once there, gregarious and over-sharing neighbor Kim immediately reaches out with an offer to mentor Reba as she adjusts to Southern California. With a new home and a much more liberal west coast set of rules, Reba, her kids and mom welcome the change, but soon realize that the open-mindedness of Southern California goes much farther than they'd expected. When Reba finds that trying to get her foot back in the music business is going to be an uphill battle, she befriends Geoffrey, the assistant to her record label's president -- who never seems to be in the office. Though overwhelmed and feeling out of place, Reba realizes that, all in all, family is what matters most, and they must learn to view their new Malibu lifestyle as a chance for a new beginning.
Written by Kevin Abbott
Directed by John Pasquin
Guest Stars: Jeffrey Nordling as Bobby, Hudson Thames as Sage
Malibu Country is a multi-camera sitcom from ABC Studios and Laura Ziskin Productions. It is executive-produced by Kevin Abbott (Last Man Standing, My Name Is Earl, Reba), Michael Hanel (Reba, Titus), Mindy Schultheis (Reba, Titus), Reba McEntire, Narvel Blackstock, Dave Stewart (member of the rock group The Eurythmics), who also created the series, and Pamela Oas Williams (The Amazing Spider-Man).
In the "Pilot" episode, a video segment is shown on Celebrity Insider Network that shows that Reba's country music singer husband, Bobby Gallagher, cheating on her with another woman. Bobby announces at a press conference that he is suspending his "These Vows Are Sacred" tour to spend more time with his family. Reba tells the crowd that she's leaving his lyin', cheatin' butt. Reba loads up her family in the car and drives to Malibu where Bobby has a beach-front home. Their new neighbor, Kim, introduces herself to Reba and Lillie Mae with hugs. Kim and Reba talk at the table. Cash, Reba's teenage son, wants to go back to Nashville. June introduces her new friend Sage to Reba. Reba goes to meet a record label's president and talks to his assistant, Geoffrey. Reba and Lillie Mae talk on the deck. Lillie Mae shows her the happy lollipop (medical marijuana) that she received. Later that day, she catches June and Sage kissing at Sage's house. Reba tells the family that she's moving them back to Tennessee. Reba and Lillie Mae have a heart-to-heart talk where Lillie Mae tells her that her husband also cheated on her. Reba writes a song as "The New Me" is played over the montage. Reba takes the song that she has written to show Geoffrey her hook. The episode concludes with Reba playing the song for her family's reaction.
I don't think it's the best sitcom pilot of the season, but it's certainly watchable and has potential to grow into something bigger and better. It definitely has a sitcom-y feel to it. It's kind of a throwback to the TGIF sitcoms of the 1990s and early 2000s. For a sitcom in a family-friendly timeslot, I was surprised by the amount of jokes about gays, plastic surgery and boobs, and medical marijuana. I guess kids are accustomed to those types of jokes these days, but I don't think the show is really geared towards anybody younger than 13. The laugh track volume also seems a bit high and could be lowered a bit.
They have some good things to work with in the series. The adult actresses bring a lot of comedic experience to the table. They seem to have some good chemistry already. I think Reba is a better singer than actress, but she does a good job here. She has a lot of spunk and charm. Comedy isn't easy to do, but she's always had natural appeal and good comedic timing. Lily Tomlin is a seasoned pro. Her Lillie Mae is a bit crazy and a pot-smoking grandmother. She's kind of like a modern-day Granny from The Beverly Hillbillies. She has a few good one-liners, but also a few cringeworthy ones like "I just saw a pelican poop." Sara Rue plays the upbeat friend and neighbor of Reba. Her character isn't too unlike Barbara Jean on Reba, which is probably by design. Rue looks much different here than she has in the guest appearances she's made on various shows in recent years. She's blonde and appears more curvy like her Less Than Perfect days. She's beautiful and funny no matter what size she is. Rue is pregant in real life and due in early 2013, so it's expected the producers will write that into the storylines. The teenage actors are relatively new to acting, but they do a decent job here. Juliette Angelo looks like she could really be Reba's daughter with her red hair. Jai Rodgriguez has some funny exchanges with Reba when they meet at the music agent's office. It's hilarious when he asks Reba if she's young and sexy and she asks her if there are any other choices.
Music will likely be a big part of the show. Reba performs the show's theme song, Goodbye Looks Good On Me. It wasn't used in the screener copy, so I don't know if it will be heard in the pilot episode that airs. It's expected that a full version will be heard in an upcoming episode. Reba does sing a new song called The New Me in the pilot episode. It was co-written by Dave Stewart of The Eurythmics, who also helped create the show. Another interesting news item that I've read is that they are trying to get Carol Burnett to play Kim's (Sara Rue) mother on the show. How great would it be to see her work with Lily Tomlin? I would also expect that Reba's country music friends and maybe some of her former Reba cast members will eventually make guest appearances. Rapper Travie McCoy is appearing as himself in an upcoming episode.
Reba's new sitcom is a lot like her old one. It comes from some of the same producers of Reba. Reba had a successful six-season run from 2001-2007. The show remains very popular on DVD and in syndication to this day. I can't really blame them for trying to model her new sitcom after it. It's a format that McEntire appears to be comfortable with. She has said in interviews that she loves to be on television. This time she plays a single mother of two kids, down from three in her old series. Her character's first name is also Reba. Sara Rue plays a similiar character to the ditzy Barbara Jean on Reba. The uniqueness of the show is that they're putting a family from Tennessee into California. It's kind of like a modern-day Beverly Hillbillies, so it should set up some funny moments. The adult cast brings a lot of comedic experience and all of the characters are very likable. Reba is in every scene, so I think they will need to expand the roles of some of the supporting characters in future episodes. The show could use a little less Reba and a little more of the delightful Sara Rue. Much will be made about Reba's return to television after a five-year break, but I'm more excited to see Rue in a lead role instead of the guest appearances she's been making in recent years.
Malibu Country is being paired with the Tim Allen multi-camera sitcom Last Man Standing on Friday nights. ABC hasn't aired many sitcoms on Fridays in recent years, so it's nice to have these two form a mini-TGIF block. They are now referring to it as ABC Comedy Friday. Reality shows and dramas have dominated the schedules on Fridays in recent seasons. It's just nice to see the networks schedule more scripted series, especially multi-camera sitcoms. I expect Malibu Country to do pretty well on Fridays. The competition isn't very fierce. Reba has an instant and loyal fanbase already because of her singing and acting career. Reba aired on Friday nights on The WB/The CW and always did well with women in the 18-49 demo. I would expect it to gain even more viewers on a bigger network. If you're a fan of Reba or any of the other actors in the series, you will certainly want to check this one out and see how it develops. Visit Malibu Country on Friday nights on ABC at 8:30pm/7:30c.
Watchability: 3.5/5
Overall: 3.5/5
-- Reviewed by Todd Fuller on 11/01/12
Discuss the show after you watch it on Friday, November 2 on our message board.
ABC.com Official Site
Malibu Country Photo Gallery
Posted by Todd -- SitcomsOnline.com at 2:00 PM
Labels: ABC, Malibu Country, Pilot Reviews
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redpajama_set_name: RedPajamaCommonCrawl


A major barrier for cancer immunotherapy is the presence of suppressive cell populations in cancer patients, such as myeloid-derived suppressor cells MDSC Active biotech byter vd 3 tumor-associated macrophages TAMwhich contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis.
Tasquinimod is a novel antitumor agent that is currently at an advanced stage of clinical development for treatment of castration-resistant prostate cancer. A target of tasquinimod is the inflammatory protein SA9, which has been demonstrated to affect the accumulation and function of tumor-suppressive myeloid cells. "Active biotech byter vd 3," we report that tasquinimod provided a significant enhancement to the antitumor effects of two different immunotherapeutics in mouse models of cancer: Taken together, these data suggest that pharmacologic targeting of suppressive myeloid cells by tasquinimod induces therapeutic benefit and provide the rationale for clinical testing of tasquinimod in combination with cancer immunotherapies.
Immunotherapies have gained momentum in cancer therapeutics following the recent approvals of drugs for the treatment of prostate cancer and melanoma. Sipuleucel-T dendritic cell DC vaccine is now available for treatment of patients with asymptomatic or minimally symptomatic, metastatic, castration-resistant prostate cancer [ 1 ].
Clinical observations have indicated that melanoma is an immunogenic tumor [ 2 ], and extended survival data have led to the approval of immune checkpoint inhibitor ipilimumab for the treatment of metastatic melanoma [ 3 ].
However, despite these clinical advances, immunotherapies for these diseases and solid tumors in general, benefit only a subset of patients, as intrinsic or acquired tumor immune tolerance remains a major hurdle. A significant barrier in vaccine therapy is the presence of immunosuppressive soluble and cellular components including myeloid-derived suppressor cells MDSC [ 4 ] and tumor-associated macrophages TAM [ 5 ], which are Active biotech byter vd 3 by tumor- and stroma-secreted inflammatory mediators [ 6 - 8 ].
Tasquinimod, a quinolinecarboxyamide analog, is in clinical development for treatment of prostate cancer and other solid tumors. In a placebo-controlled, phase II randomized trial, tasquinimod doubled the median progression-free survival PFS period and prolonged survival of patients with metastatic, castration-resistant prostate cancer [ 1415 ]. Tasquinimod has been shown to inhibit prostate cancer growth and metastasis in animal models [ 16 - 18 ]. However, in an orthotopic, metastatic prostate cancer model, tasquinimod reduced the metastatic rate without affecting microvessel density in the primary tumor [ 18 ].
Therefore, mechanisms other than impairing angiogenesis may play an important role in the antitumor and anti-metastasis activities of tasquinimod. SA9 interacts with pro-inflammatory receptors Toll-like receptor 4 TLR4 and receptor of advanced glycation end products RAGEand this interaction is inhibited by the specific binding of tasquinimod to SA9 [ 22 - 23 ]. These receptors are expressed on the surface of multiple myeloid-cell populations, including MDSCs, macrophages, DCs, as well as endothelial cells.
Functionally, SA9 regulates the accumulation of MDSCs and inhibits DC differentiation [ 24 ] [ 25 ], which may lead to suppression of immune responses and tumor progression. Therefore, by targeting SA9, tasquinimod has immunomodulatory activity and the potential to regulate multiple myeloid populations.
In this study, we tested the effect of tasquinimod "Active biotech byter vd 3" immunosuppressive myeloid-cell populations and investigated its immunomodulatory activity. We conducted preclinical studies of tasquinimod in combination with two different immunotherapeutic approaches in mouse models of prostate cancer and melanoma.
Our results suggest that treatment with tasquinimod affects the tumor microenvironment by modulating suppressive myeloid-cell populations, leading to augmented immune responses and enhanced antitumor effects of immunotherapies. The tumor size was measured by a caliper twice a week. At the Active biotech byter vd 3 of the 3—4 week experiment, tumors and spleens were collected and analyzed.
Bh5T4 cells were cultured as described above, counted, re-suspended and maintained in iced-cold matrigel BD Biosciences, San Jose, CA at a concentration of 0. Tumor cells were implanted s. Experiments were terminated between day 16 and day Cell pellets were treated with ACK lysing buffer Biosource. Single-cell suspensions were prepared from tumors with mouse tumor dissociation kit Miltenyi Biotech.
Alternatively, the tumors were cut into small pieces and incubated in 0. The following fluorochrome-labeled antibodies were used: Brefeldin A Sigma was added to the cultures to block protein secretion.
Brefeldin A Sigma was added to the cultures during the last 5 hours of culture to block protein secretion. Cells were harvested and stained for surface markers, then fixed and stained for intracellular Granzyme B eBioscience and analyzed by flow cytometry. Cells were then harvested and the incorporated 3 H-thymidine was detected Active biotech byter vd 3 scintillation counting.
After a 5-hour incubation, all cells in culture were harvested and PI staining was performed to detect dead cells. Cell cytotoxicity was analyzed by calculating percentage of dead cells with Dio label compared to the whole cell population with Dio label.
Representative photos were taken and the density of CDpositive cells fluorescence was measured with Leica QWin image analysis system. Sections were de-paraffinized and rehydrated through graded alcohol washes. Sections were further incubated in hydrogen peroxide to reduce endogenous activity. Then tissue section were blocked with 2. Section were dehydrated and mounted with cytoseal 60 Thermo Scientific.
Corresponding isotype negative controls were used for evaluation of specific staining. Stained sections were analyzed under bright field using the Zeiss Axio microscope. The number of positive cells was determined in a blinded fashion by analyzing four random 20x fields per tissue and quantified using Image J software.
The primers used for target genes were: The assay was performed with an ultra sensitive assay for nitric oxide synthase from Oxford Biomedical Research Cat: Briefly, lysates from isolated CD11b cells were first incubated with substrates and cofactors.
Then the mixtures were incubated with nitrate reductase to transform nitrate to nitrite, and mixed with coloring reagent to quantify total end-product concentration. These reactions were performed in a well plate and absorbance was read at nm. The difference in tumor weight between treatment groups was statistically evaluated by non-parametric Mann-Whitney U test.
Results from previous studies in experimental tumor models indicated that immunomodulatory effects of tasquinimod may contribute to its antitumor activity [ 23 Active biotech byter vd 3. To investigate the potential immunomodulatory activities of tasquinimod, we tested this agent in combination with a survivin peptide vaccine SurVaxM in survivin-expressing CR Myc-CaP prostate cancer model and "Active biotech byter vd 3" a tumor-targeted superantigen in a B16 melanoma model.
Survivin is an intracellular TAA expressed in several solid tumors, including prostate cancer [ 29 ]. The combination treatment also significantly inhibited tumor growth compared to that of single treatment groups tasquinimod vs. Mice were inoculated s. When the tumors reached an average size of 25 mm 2mice were treated with vehicle, survivin, tasquinimod or the combination of survivin and tasquinimod.
Left panel shows tumor growth curves by serial caliper measurements. Right panel shows tumor weights at the endpoint. Right panel shows end of treatment tumor weights. The experiments were repeated at least twice. Results from one representative experiment are shown. Error bars indicate s. In parallel, we tested tasquinimod in combination with a Active biotech byter vd 3 immunotherapy approach, tumor-targeted superantigens TTS in a transplantable B16 melanoma model.
TTS immunotherapy activates and directs T lymphocytes to attack tumor cells by means of fusion proteins between bacterial superantigens, such as staphylococcal enterotoxin A SEAand Fab-fragments of tumor-reactive monoclonal antibodies mAb [ 32 ].
Tasquinimod treatment began the day after tumor-cell inoculation and 5T4Fab-SEA was administrated on days Active biotech byter vd 3 the combination of tasquinimod with two different immunotherapeutic strategies resulted in a significant enhancement of antitumor effects. Splenocytes were isolated from differentially treated mice, stimulated and then stained for cell-surface markers and intracellular proteins.
Propidium iodide was added at the end of incubation to detect tumor cell death. FACS analysis of tumor-infiltrating T cells performed at the endpoint of the experiment depicted in Fig. Consistent with enhanced antitumor activity observed following combination treatment, splenocytes from these mice displayed significantly improved tumor-cell killing capacity as compared to those from other treatment groups Fig.
Thus, these results suggest that the combination therapy does not enhance CTL activity per se but rather inhibits T cell-suppressing factor s in the cultured splenocytes. Tumor-infiltrating cells were analyzed at different days day to follow the kinetics of specific T-cell expansion. Tasquinimod has been reported to display anti-angiogenic activity in prostate cancer models [ 1934 ]. To determine whether the anti-angiogenic effect of tasquinimod was involved in enhancing the antitumor effects of immunotherapy, we assessed the microvasculature density CD31 expression in the harvested tumor tissue by either immunofluorescence or immunohistochemistry analysis in the two therapeutic strategies, respectively.
The results showed that tasquinimod treatment reduced microvasculature density in B16 tumors Fig. In summary, these results suggest Active biotech byter vd 3 the immunomodulatory effects of tasquinimod may be dissociated from its anti-angiogenic activity; and in the Bh5T4 tumor model, the tasquinimod-induced inhibition of tumor blood vessel formation, may account at least in part for its antitumor effect in this model.
SA9 is an inflammatory protein that affects the accumulation of immunosuppressive myeloid cells, including MDSCs [ 24 ] [ 25 ]. Tasquinimod binds to SA9, inhibiting its downstream signaling, and thus has the potential to affect myeloid cells. To investigate the mechanism of immune-promoting activity of tasquinimod in combination with immunotherapy, we analyzed the peripheral and tumor-infiltrating myeloid-cell populations.
In the CR Myc-CaP tumor model, blood samples were taken from differentially treated mice after two weeks of treatments and subjected to immunofluorescence staining and FACS analysis. In addition, tumors were harvested from differentially treated mice and processed into suspension. Interestingly, tasquinimod significantly reduced the number of tumor-infiltrating MDSCs when given as a single agent or in combination with the vaccine Fig.
FACS plots and quantifications are depicted throughout. A comparable picture was also seen in the spleen Active biotech byter vd 3 Fig. Thus, the decrease in microvasculature density by tasquinimod in the B16 model could be the consequence of reducing pro-angiogenic monocytic cells within the tumors. Tumor-associated macrophages are important components of the immunosuppressive TME.
When infiltrating the tumor tissue, these cells adapt to the environment and differentiate into TAMs by losing Gr1 marker expression and gaining an even more immunosuppressive M2 macrophage phenotype [ 36 ] [ 37 ] [ 38 ]. Therefore, we assessed the effect of tasquinimod on TAMs. Similarly, analysis of macrophages in Bh5T4 tumors also revealed a strong reduction of this subpopulation in tasquinimod-treated mice Fig.
In addition to MDSCs and TAMs, we also investigated whether tasquinimod treatment affects immune-promoting activities of other myeloid and lymphoid cells. Tasquinimod did not impair T-cell expansion upon activation either in T cells isolated from differentially treated mice Supplementary Fig.
Tregs represent an immunosuppressive lymphocyte population whose accumulation can be regulated by MDSCs. DC differentiation has been shown to be regulated by the SA9 protein [ 24 ]. Although tasquinimod slightly reduced the number of DCs in the spleen Supplementary Fig. These data suggest that immunosuppressive myeloid cells, such as MDSCs and TAMs but not other myeloid or lymphoid populations are the potential cellular targets of tasquinimod and they may be responsible for the immune-promoting activity of tasquinimod in combination with immunotherapies.
Taken together, these results suggest that tasquinimod modulates not only the infiltration but also the suppressive capacity of tumor-infiltrating myeloid-cell populations. This observation led us to investigate the expression of two mechanistically relevant genes, Arg1 arginase-1 and iNOS induced nitric oxide synthase in the tumor-infiltrating myeloid cells Fig.
It has been reported that Arg1 gene expression can be regulated by TLR4 pathway [ 39 ], which is Active biotech byter vd 3 target receptor for SA9. Li Shen. 1Genitourinary Program, Roswell Park Cancer Institute, Buffalo NY. A phase III clinical trial to test the effect of tasquinimod in the same patient at Roswell Park Cancer Institute and Active Biotech, respectively. groups ( tasquinimod vs. combination p= ; survivin vs. combination p= ). FBL manufactures Cholecalciferol (Vitamin D3), Penicillin G Acylase, Candida Fermenta Biotech Ltd (FBL), incepted under the auspices of Duphar Interfran Ltd (now D3 feed grade for use in animal feed supplements; and activated.
Biotechnology and Bioengineering Symposium Series 15, — Phelan, M. B., Crawford, D. L. and Pometto III, A. L. (). Cloning and expression in biologically active form of the gene for human interferon Ryu, D. D.
Y., Kim, K. 5 ., Che, N. Y. and Pai, H. S. Scott, C. D., Strandberg, G. W. and Lewis, S. N. ( ).


Posted on December 26, 2010 by John McHugh M.D.
It's cold in Georgia right now!
Howdy would you mind letting me know which hosting company you're using? I've loaded your blog in 3 different browsers and I must say this blog loads a lot faster then most. Can you suggest a good internet hosting provider at a reasonable price? Thanks, I appreciate it!


text:
namespace raksha::ir::types {

namespace ir = raksha::ir;

TEST(PrimitiveTypeTest, KindReturnsCorrectKind) {
  PrimitiveType primitive_type;
  EXPECT_EQ(primitive_type.kind(), TypeBase::Kind::kPrimitive);
}

TEST(TestGetAccessPaths, TestGetAccessPaths) {
  PrimitiveType primitive_type;
  absl::flat_hash_set<ir::AccessPathSelectors>
      access_path_selectors_set =
        ir::AccessPathSelectorsSet::CreateAbslSet(
            primitive_type.GetAccessPathSelectorsSet());
  ASSERT_EQ(access_path_selectors_set.size(), 1);
  ASSERT_EQ(*access_path_selectors_set.begin(), ir::AccessPathSelectors());
}

}  // namespace raksha::ir::types

redpajama_set_name: RedPajamaGithub


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If you ask most people to describe a 1967 Shelby GT500 Mustang, they're going to picture the car from Gone in 60 Seconds because let's face it, that's probably the only one most people have seen. But for those who live and breathe Shelby history, there's another more important car called Little Red, and it was thought to have disappeared. Until now.
Craig Jackson, founder of the Barrett-Jackson auction house, and a team of experts have found the second 1967 GT500 EXP prototype ever built, Little Red, the sister car to the famous Green Hornet. Jackson made the announcement that he had discovered the car during the annual Woodward Dream Cruise in Michigan this weekend.
"Finding Little Red is the discovery of a lifetime," said Jackson. "This Shelby prototype has been one of the most sought-after and elusive vehicles in postwar history. Countless enthusiasts and experts have searched for Little Red since it went missing in the 1960s. Many believed it was destroyed when the car was no longer needed. I'm excited to announce that was not the case. We've found Little Red and we intend to meticulously restore this legendary car back to its original glory."
The car was located in rural North Texas after having been missing for decades, and now Jackson and his team are working to piece together the vehicle's history before it went into storage by crowdsourcing information.
People searching for the vehicle previously had tried to track it down via its Shelby VIN number. The team behind Jackson's effort were able to find the vehicle by using its original Ford VIN number, something which took considerable digging to find. Eventually, the team was able to track down the car's current owner and contacted him via social media.
"Locating Little Red was tantamount to finding the proverbial needle in a haystack," said Jason Billups, Mustang expert and team leader. "After our initial research we realized that, like others before us, we were using the wrong search criteria. Everyone looked for Little Red using the Shelby serial number, which would eventually lead to a dead end. We took a different approach and located the car's original Ford VIN number, which wasn't easily discoverable. That VIN led us to its original registration and eventually to its last owner."
The owner granted Jackson and his crew access to his North Texas property on March 3 to view the car, and was himself allegedly surprised to learn of the car's historic significance. The vehicle is set to undergo a total restoration by marque experts, which will be documented and shared with enthusiasts online.


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An exciting opportunity has arisen for a driven individual to join our award winning, energetic and experienced lettings team in Bishopston.
Saturday's 9am-4pm (with lieu day in the week).
As the property administrator you will be organised, efficient, able to work quickly and accurately under pressure whilst maintaining excellent customer service at all times.
The role focuses on progression of tenancy applications and agreements to move in date this will then lead to maintaining regular contact with applicants, clients, etc.
learn...we can teach the rest!


Your children's eyes are exceptionally important - a cruical tool for learning, discovering new things and calculating the world around them. Children are mostly taught visually too, so it's a very important asset that helps them learn and develop.
White looking eyes in photographs or in low light - it is extremely serious – if you notice it, you should seek medical attention immediately.
Testing before your son or daughter goes into education means that any issues that they may have can be identified early, getting them ready for a happy and fulfilling time at school. That's because not being able to see clearly can be diffcult to deal with, especially in a busy classroom.
Our trained opticians are specially trained to test children's eyes, and have the experience to make it a comfortable experience.


When you run your own automotive repair business, time is money. The longer it takes to get the job done, the longer it takes to get paid and the longer it takes to move on to the next job. If you like to do your auto repairs yourself, then you will also agree that there's nothing worse than waiting for Buick Rendezvous Parts. It's easy to become impatient when you just want to get the job finished. Luckily, there's a better way. UNeedAPart.com networks over 7,000 parts shops so finding the exact Buick Rendezvous Parts you need can be done easily and best of all, quickly. Plus, all of the benefits from using UNeedAPart.com can be taken advantage of by both auto repair professionals and individuals alike.
UNeedAPart.com is your ultimate access for everything you need to make your or your customer's Buick Rendezvous looking and running like new. We carry everything from Used Buick Rendezvous Engine to Rendezvous Accessories. If you need Buick Rendezvous Wheels, or a harness or diagram, we can find these for you. Take a look at our massive inventory of Buick Rendezvous Parts. If there's a part that's not available from our comprehensive list of parts dealers, odds are that the part doesn't exist!
Finding the right Buick Rendezvous Parts is easy! To get started, simply use the Parts Request boxes at the top and/or side of the page. You will instantly be matched with auto parts dealers that meet your search criteria. UNeedAPart.com helps you find the new or used auto body parts you need in no time!


IncrediFlash Intro and Banner Studio - Software Informer. Position, rotate and resize your texts by dragging handles on a preview window.
IncrediFlash Intro and Banner Studio is a very easy and powerful tool to create a Flash animated intro and banner without any Flash knowledge using a wizard-driven user interface. Easily position, rotate and resize your texts by simply dragging handles on a preview window.
Guest It's impossible for me to import the serial, because of no Internet connection.
But the Internet is on. When I ask support, I never get an answer.


This week we watched one of our favorites, The Emperor's New Groove! This movie is just plain funny!
I loved coming up with Disneybound ideas for this movie. All the colors are fun and bright and very different to what I would normally pick in an outfit! I love how this challenge has forced me to get out of my "rut" when it comes to outfits and put together things that are out of my box.


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Home Other Tech Apps TikTok is finally available to download from App Store and Google Play...
TikTok is finally available to download from App Store and Google Play Store in India
Popular video-sharing app TikTok is now finally back on Apple's App Store and Google's Play Store in India. This step has been taken after the Madras High Court lifted ban on the Chinese video app last week. Prior to this, the TikTok app was delisted from both the app stores after the Madurai Bench of the Madras High Court issued an order to the Centre to get it removed.
The ruling came after a PIL was filed against the social media app saying that TikTok escalated pornography and child abuse. However, later on, the ban was lifted when TikTok agreed that it will monitor content on its platform and ensure that pornographic videos are not uploaded on it.
Once the ban was imposed by Madras High Court, the TikTok app was unavailable on Google's Play Store as well as Apple's App Store. It has been reported that the developer of the application – Beijing Bytedance Technology Co – had to bear a financial loss of up to $5,00,000 per day. The company also said that the ban put more than 250 jobs at risk.
We should mention that these financial losses include destruction in the value of its investments and loss of commercial revenue of the app. ByteDance had also said to the court that the ban would result in the reputation and goodwill taking a hit with advertisers as well as investors.
According to the company's plea that it submitted to the court, "Banning has had adverse impact on the user base of this app, losing close to 1 million new users per day…It is estimated that approximately six million requests for downloads could not be effected since the ban came into effect."
While the ban got lifted last week, the app was still unavailable to download from the App Store and Google Play Store until now. The Chinese app is now available to download from both the app stores. So, in case you haven't downloaded it and wanted to try it out, you can now head to the app store to get the app.
According to Sensor Tower, TikTok had 88.6 million users in Q1 2019 in India. The ban on the Chinese social media and video sharing app has in general become a cause of concern for the social media industry in India as they may have the same fate if content on their respective platforms is not regulated.
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Our mountain town is a true year-round destination with activities to match. See a quick list of fall, winter, spring and summer team building adventures that will allow your group to take advantage of the playground that is Park City.
Zipline in Park City: Take advantage of the elevated landscape. Zip line above Park City's tree line as you take in the beautiful Wasatch Mountain range.
Take a Teamworks excursion: Go mountain orienteering, hiking or do special challenges that accommodate groups of up to 15-150+ people.
Go mountain tubing: Soar down the Rocky Mountains atop an inner tube. Build relationships through an adrenaline-charged adventure.
Take a Team Cooking Class: Team build through communication and creativity, while getting a tasty meal out of your group cooking experience.
Go fly fishing: Let Park City's anglers plan a tailor-made experience for a group fly fishing adventure on one of Utah's beautiful rivers.
Visit Utah Olympic Park: Enjoy an adrenaline-oriented experience through a challenging ropes course, zip lines, tubing course and more.
Explore Mountain Trails: See the mountains from the mountains. Explore 400 continuous miles of recreational Park City trails.
Go Tubing & Rafting: See the beauty of Park City from the water. Take part in an unrestrained team building activity that's fun and refreshing.
We've only skimmed the surface for this list of team building adventures in our mountain town. Visit Park City provides complimentary team building planning services to help you create experiences that are fully customized and perfect for your group of adventure-seekers, no matter the season. Yes. All That.


text:
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text:
/ Cory Doctorow / 10:00 pm Fri Jan 24, 2014
Study: French three-strikes law did not deter or reduce piracy
In Graduated Response Policy and the Behavior of Digital Pirates: Evidence from the French Three-Strike (Hadopi) Law a team of business-school researchers from the University of Delaware and Université de Rennes I examine the impact of the French "three-strikes" rule on the behavior of downloaders. Under the three-strikes law, called "Hadopi," people accused of downloading would be sent a series of threatening letters, and culminating with disconnection from the Internet for a period of a year for everyone in the household. Hadopi is the entertainment industry's model for global legislation, and versions of it have been passed in the UK and New Zealand, and it has also been proposed for inclusion in the global Trans-Pacific Partnership treaty.
The researchers carefully surveyed French Internet users to discover what effect, if any, the Hadopi law had had on their behavior -- specifically, whether they were encouraged to download more from legitimate sites and pay more for music as a result of the threat of Hadopi. Their conclusion: [Hadopi] has not deterred individuals from engaging in digital piracy and that it did not reduce the intensity of illegal activity of those who did engage in piracy.
The study found some evidence that determined pirates who are more well-informed about the law may have shifted away from using P2P networks and towards other methods of illegally sharing content, like "direct downloading" sites and newsgroups.
The study is based on self-reported data, coming from a survey of 2,000 French Internet users. The respondents were asked about their views on and knowledge of the Hadopi law.
More than a third—37.6 percent—admitted to illegal downloading, with 22 percent using P2P networks and 30 percent using "alternative channels." About 16.4 percent of those who had engaged in the downloads received a warning from Hadopi, the government agency with the same name as the law it enforces.
Users who were more aware of the monitoring done by the Hadopi regime weren't any less likely to pirate copyrighted material, although there was a slight affect on the "intensity" of downloading. (The researchers asked whether users were likely to use illegal downloading techniques more than once a month or less than once a month.) The overall effect on file-sharing intensity was "negative but insignificant," researchers wrote.
Graduated Response Policy and the Behavior of Digital Pirates: Evidence from the French Three-Strike (Hadopi) Law [SSRN]
Study of French "three strikes" piracy law finds no deterrent effect [Joe Mullin/Ars Technica]
(Image: HADOPI, a Creative Commons Attribution (2.0) image from goodvibez's photostream)
3 strikes / Business / Copyfight / corporatism / corruption / france / hadopi / law / scholarship
Cooperative porno copyright troll gets 5 years in prison, while his co-conspirator got 14 years
Last month, Paul Hansmeier was sentenced to 14 years in prison and ordered to pay $1.5m in restitution for the copyright trolling his firm, Prenda Law, engaged in: the firm used a mix of entrapment, blackmail, identity theft, intimidation and fraud to extort millions from its victims by threatening to drag them into court for […]
Judge rules that EFF's DRM lawsuit can proceed!
In 2016, EFF sued the US Government on behalf of Andrew "bunnie" Huang and Matthew Green, both of whom wanted to engage in normal technological activities (auditing digital security, editing videos, etc) that put at risk from Section 1201 of the Digital Millennium Copyright Act.
Pacman in 512 bytes
Pillman is Oscar "Nanochess" Toledo's reimplementation of Pacman ("a game about a yellow man eating pills") in 512 bytes -- small enough to fit in a boot sector -- written in 8088 assembler. (via Four Short Links)


15 Common Cycling Injuries and How to Prevent Them What is usually thought of as a happy-go-lucky ride can sometimes have unseen and often neglected consequences. Like any physical activity, cycling has an element of risk in regards to the injuries that you can develop. Whether you're improperly riding your bike, skipping on stretching sessions, or aggravating old conditions such as a torn rotator cuff, there are common cycling injuries that you can easily prevent….


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20 Fantasy Hockey Thoughts
by Mario Prata on August 12, 2018
Every Sunday until the start of the 2018-19 regular season, we'll share 20 Fantasy Thoughts from our writers at DobberHockey. These thoughts are curated from the past week's "Daily Ramblings".
Writers: Michael Clifford, Ian Gooding, Cam Robinson, and Dobber
1. Will people still consider Nicklas Backstrom a premier asset heading into drafts this season? Last year, he was the 20th player off the board in Yahoo leagues. This was after he produced an 86-point campaign in 2016-17. That season, he played around 60 percent of his even-strength minutes next to Alexander Ovechkin. He produced 36 power-play points and hadn't yet turned 30.
Heading into 2018-19, things aren't so rosy. His production dipped to 71 points in 81 games. His power play production was the lowest per-game since 2010-11 and he'll be 31 by the time puck drops this fall. His five-on-five time with Ovechkin was around 580 minutes – roughly the same percentage as the year prior.
The big playoff run will help ease some GMs concerns about taking the Swedish pivot early. However, the emergence of Evgeni Kuznetsov cannot be overlooked. The younger Russian played roughly 475 even-strength minutes with Ovechkin last season. But the two were connected at the hip down the stretch and throughout the playoffs. The results were fruitful.
Backstrom has proven to be a reliable performer. His ability to generate offense away from Ovechkin is admirable. However, it's not at the same level it could be if he was consistently dishing the puck to this generation's greatest goal scorer. With the extreme depth at the centre position, there's no need to jump up and grab Backstrom in the first two rounds. Hell, I may even wait until closer to the 35-spot to take a swing on him. (aug11)
2. One of the most underrated players of this generation, Blake Wheeler has been lethal on the power play for the Jets (having Patrik Laine and Mark Scheifele helps). Can he replicate the 40 power-play points (!) he had last year? That's a pretty tall task. Seems likely he comes down to the 75-80-point range he had been the previous couple seasons. Then again, there is a lot of talent on that top power-play unit. He has one year left on his deal and will be 33 years old for the 2019-2020 season. (aug7)
3. Is anyone else a little concerned that Dallas Stars' new bench boss, Jim Montgomery, will be inclined to split his top line to spread out the offense? We can assume at least one of Jamie Benn or Alex Radulov will get to live next to soon-to-be potential upcoming unrestricted free agent, Tyler Seguin, next season. But, will the other end up driving offense from the second line to help get Jason Spezza and company going?
The Stars top line produced 103 of the team's 231 total goals. Seventy-three (73) of those goals came at even-strength, where the team scored 187 total goals. That's 40 percent of the team's offense during five-on-five play. Meanwhile, no other forward cusped the 20-goal or 35-point mark. The secondary scoring is non-existent in Big D.
It's certainly a situation to watch carefully. Seguin will reap the best of everything as he's the focal point of the attack down the middle. The team will also be looking to give him every reason to sign a massive extension before testing the market next July. Benn and/or Radulov could be seeing their even-strength production take a dip next season if they end up away from the top line. (aug11)
4. How much does Shayne Gostisbehere's value depend on Claude Giroux and Jakub Voracek's ridiculous power play production? Giroux has a history of racking up massive production on the power play. Over the past five seasons, he's averaged 34 points on the man-advantage. And his 168 total PPPs over that time are tied for most in the league with Nicklas Backstrom. Voracek has been a little more inconsistent, producing 23 power play points in three of the last five seasons. But, he's sprinkled in 33 in 2014-15 and 35 last season.
Gostisbehere saw his average powerplay deployment dip by 15 seconds per night last season. Yet, his power play production shot up from a previous career-high of 23 to the 33 he experienced last season. That result led all blueliners and has propelled him to being one of the best fantasy hockey blueliners out there.
For those who concern themselves with Ivan Provorov breathing down Gostisbehere's neck, don't. Let's say the Flyers decided to promote Provorov to the top unit. The increase in his level of production would pale in comparison to the deficit that moving Gostisbehere off of it would cause. This is a Kevin Shattenkirk–Alex Pietrangelo situation all over again. The club will play their players to their strengths. That means Gostisbehere gets all the fun minutes and Provorov remains an all-around stud who is limited offensively due to his deployment. Until the Philly power play begins to show signs of slowing, Gostisbehere will remain an elite producer. (aug11)
5. In case you're wondering where Brady Tkachuk might fit in now, the Sens have a number of established NHL-level players at the left wing position. But, with the departure of Mike Hoffman, the Sens also lack a true top-liner at that position. So, Tkachuk could receive an opportunity to latch on to a scoring line right away.
It's anyone's guess whether Tkachuk would stay in Ottawa for the full season or not. But it's worth mentioning that brother Matthew went straight to the Flames right after being drafted and stayed the entire season. So, it's possible that Brady is trying to follow the same path. But ultimately it will be the Senators' decision. If the Sens are a Canadian tire fire again, then playing in London would be a better option for the 2018-19 season. (aug12)
6. One left wing that Tkachuk will be battling for minutes with will be Ryan Dzingel. With all the turmoil in Ottawa last season (and stretching into the offseason), it's easy to overlook the fact that Dzingel tied for the team lead in goals with 23. There's lots to like with Dzingel as a potential deep sleeper. Not only is he playing for a contract, but he is also entering his fourth season (if you count his 30-game 2015-16 season). His production climbed as the season went on, which was at least partially due to his deployment with Matt Duchene later in the season.
At this point Dzingel might be the preferred choice on the top line while Tkachuk becomes accustomed to the NHL either this season or next. But long term, he's probably keeping the seat warm for Tkachuk. In the meantime, you can have fun saying the name "Dzingel!" Doesn't it just roll off the tongue? (aug12)
7. Dylan Larkin inked a five-year contract extension worth 6.1 million per season. That's a nice chunk of change coming to the 22-year-old. Larkin epitomized the dreaded sophomore slump in 2016-17. After taking the NHL by storm in the first half of his rookie campaign, things turned a little sour for the former University of Michigan standout. He witnessed a dip in goals, assists, points, shots, and time-on-ice. A great deal of that can be explained by his transition to the middle of the ice and the responsibility that comes with it.
The 2017-18 campaign was the re-emergence. He posted more than double his previous season point totals (31 to 63) and was a force at even-strength. His 53 points at five-on-five were good for 23rd in the league. Wedged between Steven Stamkos and Evgeni Kuznetsov. (aug11)
8. I'll be very interested to see what the Arizona Coyotes do with their top power-play unit this year. If we look at their PP line combinations from Frozen Tools, their three most-common PP lineups had three forwards and two defensemen. However, with the addition of Alex Galchenyuk and the hopeful emergence of Dylan Strome, as well as the lack of scoring talent down the lineup, it would make sense for the team to run a heavily-used four-forward top PP unit.
They could go with Galchenyuk-Clayton Keller–Derek Stepan-Strome-Oliver Ekman-Larsson and just play them 70 percent of the time. It would give them four lefties but that's not really a huge issue. You can have Galchenyuk on his off-hand wall, Strome or Keller on their strong-side wall, the remaining forward and Stepan playing low/high in the slot with OEL on the point.
Maybe it's just wishful thinking, but it seems to me they finally have the offensive pieces necessary to run a very threatening top PP unit. Arizona was bottom-10 in five-on-four goals last year and if this team wants to earnestly push for a playoff spot, a boost on the PP would go a long way in helping. It'll be curious to see what they run in exhibition games. (aug10)
9. Eric Staal has been lights out for the Wild since they signed him, culminating with 42 goals last year, 11 of them on the power play. For reference, he had 12 power-play goal totals from 2014-2017 combined. He hadn't cracked the double-digit goal mark on the PP since 2010-11.
Minnesota is a team that splits their power-play units to a degree which, as written above, is a concern. He shot 28.12 percent at five-on-four last year. If that comes down to 10 percent, or so, in 175 five-on-four minutes, that's a huge crash in production. Just that loss in PP goal production alone would knock him down to 35-ish goals. I don't think anyone expects him to repeat 42 goals again but just be aware of where the goal drop will come from. In leagues that count PP goals (or even PP points), it could be a double-whammy as the loss in production will likely come from the man-advantage side. (aug10)
10. With the Sedin twins gone, there is presumably two open spots on Vancouver's top power-play unit. Sven Baertschi signed a three-year deal with the Canucks and though they have some young guys coming up among their proven, top-end forwards, they have two. And one of them is a sophomore. Does Baertschi crack that top unit? There is Adam Gaudette, Elias Pettersson, and Jonathan Dahlen, but how many rookies do they want to put on PP1? Surely, Baertschi won't shoot 30 percent at five-on-four again,but if he can manage to skate with Brock Boeser and Bo Horvat at 5v4 for most of the year, that extra ice time could mitigate some of the percentage drop. We'll see. There are a lot of moving parts in Vancouver this year. (aug10)
11. Ryan Johansen has a 33-goal season to his name, which was followed up with a 26-goal season. His last three seasons, though, have seen totals of 14, 14, and 15. His last two years have seen fewer total power-play goals (five) than either of his seasons with the Blue Jackets from 2013-2015. Now, when you skate with Filip Forsberg and Viktor Arvidsson, there really aren't many shots left to go around and Johansen doesn't need to be a scorer. That doesn't mean he can't pop a handful of power-play goals this year, though, especially if his five-on-four shooting percentage rebounds from a six-year low of 3.7 percent.
Again, Johansen isn't a scorer now, and he doesn't need to be. With a bit of good fortune at five-on-four, though, he could push for 20 total goals. That's not overly impressive, but it's better than what he's done lately. (aug9)
12. Once a prolific goal scorer on the power play, Bobby Ryan had just one PP goal last year and two the year before. When you look at just five-on-four power plays, he had zero goals in 2017-18 and two in 2016-17. That's two goals at 5v4 over a span of 124 games and 302 power-play minutes. This is from a guy who once posted back-to-back double-digit 5v4 goal seasons.
Ryan's hand injuries over the last few years are lengthy and well-documented. It's a wonder if he'll ever get over them again. With the exodus of talent in Ottawa of late, there should be a lot of PPTOI available for Ryan if he can stay healthy. And that is a big, big if. (aug9)
13. Helen St. James covers the Red Wings and states that the team wants to be competitive this year, which reads as playoff aspirations to me. In that vein, she thinks Jimmy Howard's starts could be reined in with the signing of Jonathan Bernier. Howard's 57 starts in 2017-18 were the most for him since 2011-12 and largely due to the underperformance of anyone else they tried to use. If Bernier can perform at the level he did the last couple years, this could be a split-start situation rather than Howard starting 50-plus again. Even if Howard performs well, he could be a trade deadline casualty.
Though there's nothing from management or coaching staff, she would like to see Filip Zadina play alongside Henrik Zetterberg if – IF – Zetterberg is healthy enough to play this year and Zadina makes the roster out of camp. Given that Zetterberg still possesses good playmaking abilities, this makes sense. There is a lot of time between now and the start of the season, though, so this is obviously just speculation for now. (aug9)
14. Though there's no official update on Ryan Suter's status, Minnesota Wild beat reporter Michael Russo said he talked to Suter and recent scans on his ankle/foot came back clean and he's been doing very light on-ice work. Suter's expectation is that he will be ready for training camp. Now, what an athlete believes and what actually happens are often two very different things but that's what we have for now.
Russo also believes we could see Nino Niederreiter on the third line this year. He says Bruce Boudreau wants to be able to throw three scoring lines at the opposition and that means there's going to be a very skilled player on the third line. That might be Niederreiter. In which case, it's a downgrade. No offense to Joel Eriksson Ek but he's not Eric Staal. If Nino has third-line minutes and split power play time, returning to his 57-point performance in 2016-17 will be tough to accomplish. He also had Charlie Coyle on that third line as well, which kind of makes sense if you want to balance things out. (aug9)
15. For anyone concerned about Vladimir Tarasenko's off-season surgery, there was some news that came out late Monday night in that regard. Long story short, there shouldn't be much to worry about from one of the league's elite snipers.
Months ago, I wrote in these Ramblings about how he could be a bounce-back candidate. That was before the shoulder injury, but I still stand by it. His average draft position (ADP), as it does with all players, will ultimately determine how much value he can return, but the revamped lineup with some natural progression from last year makes me a believer.
As with all returning injured players, though, there's always risk attached. It's up to the individual fantasy player how much, or how little, risk you want to assume in the draft. Every player has injury potential but one of the better indicators of future injury is prior injury. Tarasenko coming off long-term shoulder injury obviously fits that bill. If you're really concerned about a second- or third-round pick only playing 65 games then he can be avoided. Again, each fantasy owner is unique so the decision is ultimately up to the individual owner. (aug8)
16. I remember a week ago (or so) that fellow writer Cam Robinson was on Twitter discussing Jake Guentzel and his hopes that he would see top PP minutes this year. As a Guentzel owner in multiple keeper leagues, nothing would delight me more. Patric Hornqvist's proficiency on the power play, however, is going to be a big stumbling block. He does a very good job at playing that Wayne Simmonds-type role around the net and Guentzel is more of a slot shooter like T.J. Oshie. Guentzel isn't going to replace any of the other forwards, so it's hard to see him getting consistent top PP minutes without someone suffering an injury. (aug7)
17. Sam Reinhart is going into his fourth season (something we love around here at DobberHockey), will almost certainly play on Jack Eichel's wing (good spot to be), and is going to be on the top PP unit again. How the team fares without Ryan O'Reilly or Evander Kane in the fold is another story but the ice time and quality linemates should be there for Reinhart. Will a true breakout follow? (aug7)
18. The John Gibson signing – already discussed at length (by Ian Gooding here) but I'll chime in – was a good cap hit for the Ducks, of course, given his consistent top save percentage. But, eight years is a risk given his injury history. He had always been a little under-ranked as a prospect goaltender on my list because he was injury prone. And this was before he stepped a skate onto NHL ice!
– 2014-15: He missed the middle of the season with a groin injury – 21 games;
– 2015 playoffs: Missed seven games with a UBI;
– 2015-16: Missed two games with a UBI;
– 2016-17: Thirteen (13) games with a LBI (two injuries, or the same one twice, I don't know);
– 2017 playoffs: He missed the last game with an LBI and then had all summer to heal, so who knows how much time he would have missed;
– 2017-18: Missed one game (concussion), four games (LBI), three more games (LBI), three more games (UBI).
In four seasons in the NHL, Gibson has sustained nine injuries after having a reputation as being injury-prone well before he even turned pro. And now he's locked in for eight years. Good luck, Anaheim! Hope it pans out for you and he stays healthy. If so, it's a steal. (aug6)
19. While looking at the Ducks, Jakob Silfverberg popped out at me because he's an unrestricted free agent next summer. Here's a guy in his mid-20s who possesses more offensive talent then he's shown and is under-used offensively because he's so good defensively. Players like him always surprise in a UFA contract year – Josh Bailey and Evander Kane sure did it last year. The latter two had expected production of 50 points and they certainly exceeded that. Silfverberg is in that ballpark, too. Kevin Hayes another one. In fact, I'm just going to list the guys I think best fit this mold as I go through Cap Friendly. In no particular order: Silfverberg, Hayes, Derick Brassard, Gustav Nyquist, Marcus Johansson, Richard Panik, Joonas Donskoi.
The latter two names would be pushing the term 'breakout' but if they get into the high-50s, I'd call that a contract year. Jeff Skinner isn't on this list because he's already had huge seasons. But, I'm willing to bet two or three of the above players really surprise us in a good way. (aug6)
20. Did William Karlsson just sign the same contract that Kevin Hayes signed? That's pretty nuts. Yeah, I know, it's the 'only one year' thing…but okay, take two years then. Karlsson had 103 points in two years to Hayes at 93 and he's a year younger and scored 49 goals to 42 (game winners he's up 9-8, too). I think Vegas got a bit of a deal there but at the expense of possibly getting taken to the cleaners next summer. But the Rangers? They overpaid Hayes just a little and they let him become unrestricted at the end of it, too. You'd think they'd get a discount from his agent for helping him do that. (aug6)
Have a good week, folks!!


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Archive of posts in Education
3459 reviews in Author Q&As, Collections, Contemporary, Fiction, Fantasy, Graphic Novel, Historical Fiction, Literary, Mystery & Suspense, Science Fiction, Short Stories, Young Adult, GBF13, Non-Fiction, Art & Architecture, Biography & Memoir, Business & Economics, Computers & Technology, Cooking & Food, Cultural Studies, Education, English Language & Writing, Essays & Literary Criticism, Gender & Sexuality, History, United States, Humor, Law, Math, Medicine & Health, Mythology, Performing Arts & Entertainment, Philosophy, Poetry, Political Science, Psychology, Reference, Religion, Science, Social Science, Sports & Games, Transportation, Travel, Popular
The Illimitable Freedom of the Human Mind: Thomas Jefferson's Idea of a University
By Andrew J. O'Shaughnessy
A compelling account of what the Founding Father felt learning should look like.
Non-Fiction, Education, History, United States
Districts that Succeed: Breaking the Correlation Between Race, Poverty, and Achievement
By Karin Chenoweth
When it comes to developing good schools, there's no one-size-fits-all approach.
Non-Fiction, Education
How We Read Now: Strategic Choices for Print, Screen, & Audio
By Naomi S. Baron
A well-researched, accessible treatise on all the ways we experience and absorb words.
Charter School City: What the End of Traditional Public Schools in New Orleans Means for American Education
By Douglas N. Harris
An in-depth, apolitical look at a new way of doing education.
Raising Kids Who Read: What Parents and Teachers Can Do
By Daniel T. Willingham
A practical manual for instilling a love of books in children.
The Teacher Wars: A History of America's Most Embattled Profession
By Dana Goldstein
An engaging account of how the hurdles faced by beleaguered educators are nothing new.
Excellent Sheep: The Miseducation of the American Elite and the Way to a Meaningful Life
By William Deresiewicz
A look at the United States' time-honored tradition of lurching ineffectively from one trend to another.
Blackboard: A Personal History of the Classroom
By Lewis Buzbee
A baby boomer reflects on his life as a student.
Non-Fiction, Education, History
Lost Mars: Stories from the Golden Age of the Red Planet
Edited by Mike Ashley
This themed collection has its eyes on the stars but suffers from a thin atmosphere.
Fiction, Science Fiction, Short Stories
The Good Rich and What They Cost Us
Robert F. Dalzell, Jr.
Profiling personalities from colonial times to the modern day, this book explores the philanthropic leanings of the wealthy.


Browse market data Tables and Figures spread through 121 Pages and in-depth TOC on "Global Peony Market Research Report 2016 "
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The fundamental overview of Food Pharmaceutical Peony market, revenue statistics, market definition, product scope, industry chain structure and market share are analyzed in this report. Furthermore, the industry policies, definitions, product classification, a variety of applications, production volume, demand and supply statistics of Food Pharmaceutical Peony.
The fundamental overview of Peony Essence Oil market, revenue statistics, market definition, product scope, industry chain structure and market share are analyzed in this report. Furthermore, the industry policies, definitions, product classification, a variety of applications, production volume, demand and supply statistics of Peony Essence Oil.


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OAS » Inter-American Commission on Human Rights (IACHR) » Media Center » Press Releases » 2011 » 109
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Washington, D.C. - The Inter-American Commission on Human Rights (IACHR) met yesterday with the Human Rights Public Policy Institute (IPPDH) of the Southern Common Market (MERCOSUR), as well as with representatives of MERCOSUR member countries, as part of an ongoing dialogue on potential areas in which to cooperate and coordinate efforts.
Representatives of the Presidency Pro Tempore of MERCOSUR, currently held by Uruguay; representatives of three States Party, Argentina, Uruguay, and Paraguay; and the Executive Secretary of the IPPDH, Víctor Abramovich, were received October 20 by the full Commission, which had begun its 143rd regular session the day before.
"We believe the efforts of the MERCOSUR IPPDH and the IACHR are complementary," Abramovich said. "For the countries that make up MERCOSUR, the idea is to consider the standards of the inter-American system as a minimum in terms of human rights," he added.
In this context, Abramovich informed the Commission about the request for an advisory opinion that Argentina, Brazil, Paraguay, and Uruguay presented to the Inter-American Court of Human Rights on July 7, 2011, on the matter of States' obligations toward child migrants.
"This is the first time since 1982, when the Court began its advisory functions, that the four States have gone to the Court to request an advisory opinion. This demonstrates the firm commitment of the four States Party to MERCOSUR to continue strengthening the inter-American human rights system," said the Interim Representative of Uruguay to the Organization of American States (OAS), Graziella Reyes, speaking as representative of the Presidency Pro Tempore of MERCOSUR.
The Commissioners thanked the MERCOSUR delegation for the information it had shared and expressed their interest in working together with the Human Rights Public Policy Institute. They also informed the visitors that the IACHR is currently working on a document, to be presented to the Inter-American Court, on the rights of child migrants.
The meeting between the IPPDH and representatives of MERCOSUR countries is part of a series of efforts the IACHR is making to coordinate its work with other regional human rights organizations.
A principal, autonomous body of the Organization of American States (OAS), the IACHR derives its mandate from the OAS Charter and the American Convention on Human Rights. The Inter-American Commission has a mandate to promote respect for human rights in the region and acts as a consultative body to the OAS in this matter. The Commission is composed of seven independent members who are elected in an individual capacity by the OAS General Assembly and who do not represent their countries of origin or residence.
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Geometry is the divine pattern that underlies the world of time and space, where the forces of nature continually reconfigure the landscape. My methods in drawing and painting reflect this; shapes are laid down layer upon layer and chance plays a role in the resulting patterns. Elements of weather are suggested. Landforms show the marks of shifting planes. The geometry suggests architecture, a site plan still embryonic floats below the landscape.
charcoal & pastel on paper 18"x24"
charcoal & pastel on paper 11"x17"