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LG Spectrum for Verizon officially official, landing January 19th for $199.99
Alex Wagner
Editorial Director of News and Content
| January 9, 2012
The LG Spectrum has leaked quite a few times over the past month or so, but today the Verizon 4G LTE handset was finally made nice and official. Landing on January 19th for $199.99 with a two-year contract, the Spectrum features a 4.5-inch 1280x720 True HD IPS display that features a pixel density of 329ppi. Other specs include a 1.5GHz dual-core Qualcomm processor, 8-megapixel camera, 1080p video capture, 1.3-megapixel shooter around front, 4G LTE connectivity, 16GB microSD card and a 1,830mAh battery powering the whole thing. The Spectrum will come to market with Android 2.3 Gingerbread in tow, but LG says that an upgrade to Ice Cream Sandwich is coming in the first half of 2012. Lastly, sports addicts will be glad to know that the Spectrum will come preloaded with the ESPN ScoreCenter app that'll feature 720p HD video.
Overall the Spectrum sounds like a nice addition to Verizon's LTE lineup, especially considering the fact that it includes a large HD display and 4G connectivity in package that costs $199.99 on contract. The good news is that if the Spectrum sounds like it might be the device for you, it'll only be 10 more days before you'll finally be able to get your mitts on LG and Verizon's newest offering. Need some help passing the time until then? The full press release is available for your perusal down below.
Verizon Wireless And LG Mobile Continue Legacy Of Innovation By Offering A True HD Mobile Experience With Spectrum™ By LG
Latest LG Smartphone Boasts True HD IPS Display, Verizon Wireless 4G LTE, Dual-Core Processor and ESPN ScoreCenter App with Exclusive HD Feed
LAS VEGAS, NV, and BASKING RIDGE, NJ — From the 2012 International Consumer Electronics Show (CES), Verizon Wireless and LG Mobile today announced Spectrum™ by LG smartphone, exclusively for Verizon Wireless. Spectrum is the first smartphone for Verizon Wireless to feature a 4.5-inch True HD In-Plane Switching (IPS) display, the same display technology used in premium LG HD televisions. Intensifying its HD capabilities, Spectrum by LG will give customers exclusive HD access to the ESPN™ ScoreCenter application. Spectrum will be in the Verizon booth (Las Vegas Convention Center, South Hall, Booth #30259) and LG booth (Las Vegas Convention Center, Central Hall, Booth #8204).
ESPN's ScoreCenter app is supported by an exclusive HD video feed, giving customers the exclusive access to ScoreCenter stats, images and videos in 720p HD. Scoreboards and live game details include in-game stats, news and video. Personalization features allow fans to customize their ScoreCenter experience by highlighting their favorite teams and leagues from around the world, all in crystal clear high-definition.
Showcasing LG's True HD technology, Spectrum by LG supports 1280 x 720 resolution and offers one of the brightest and sharpest displays available on a mobile device. Spectrum's 500-nit display luminance and Real-Stripe RGB pixels offer users clear viewing in direct sunlight and accurate true-to-life color rendering.
Spectrum also features a Qualcomm® 1.5 GHz dual-core processor combined with 4G LTE connectivity for robust power, multitasking and download speeds. Verizon Wireless leads the way in 4G with the fastest and most reliable 4G network in the United States, covering more than 200 million people in 190 markets.
4.5-inch True HD IPS display provides natural colors and brilliant, undistorted HD images in 16:9 aspect ratio. Pictures and texts are incredibly sharp with 329 pixels per inch (PPI) screen density.
Protected by Corning® Gorilla® Glass, the True HD IPS display uses Real Stripe subpixel arrangement so images never get blurred.
Android™ 2.3 Gingerbread (Android 4.0 Ice Cream Sandwich upgrade available the first half of 2012); support for Google™ Mobile Services including Gmail™, YouTube™, Google Talk™, Google Search™, Google Maps™ and access to more than 300,000 apps available to download from Android Market™.
Preloaded Netflix app allows Netflix subscribers to stream the latest movies in high-definition quality.
Qualcomm 1.5 GHz dual-core processor makes multitasking seamless. Customers can surf the Web, check email and update social networks effortlessly.
ESPN's ScoreCenter app offers the most comprehensive sports coverage available on an Android device whether you follow the NFL or Premier League, ICC Champions League or MLB™, NASCAR or Formula One™. Customers can follow teams from more than 500 leagues around the world with an exclusive 720p high-definition feed for Spectrum by LG while connected to the Verizon Wireless 4G LTE network or Wi-Fi.
Spectrum supports Dolby® Digital Plus, which allows users to maximize their HD multimedia experience. Dolby Digital Plus can stream up to 7.1 channels of surround sound through home entertainment systems.
8-megapixel rear-facing autofocus camera with LED flash to snap beautiful pictures and 1080p video capture
Front-facing 1.3-megapixel camera for video chat
SmartMovie HD app—create and edit HD videos right on the Spectrum by LG
Mobile Hotspot capability—share 4G LTE connection with up to 10 Wi-Fi-enabled devices
Bluetooth® Version 3.0
16 GB microSD™ card pre-installed with support for up to 32 GB microSD card
SmartShare—share media wirelessly to DLNA®-enabled devices
HDMI mirroring capable via MHL
Spectrum by LG will be available on Jan. 19 in Verizon Wireless Communications Stores and online at www.verizonwireless.com for $199.99 with a new two-year customer agreement.
Customers who purchase a Spectrum by LG will need to subscribe to a Verizon Wireless Nationwide Talk plan beginning at $39.99 monthly access and a smartphone data package starting at $30 monthly access for 2 GB of data.
Customers Can Score the Game Winner
LG and ESPN are teaming up to give fans the chance to score an unbelievable sports weekend, including two tickets to ESPN The Magazine's NEXT Party and a trip to the big game in Indianapolis on Sunday, Feb. 5. Customers can visit www.SpectrumbyLg.com or www.verizonwireless.com/spectrum for official rules, details and a once-in-a-lifetime opportunity to be a part of sports history.
(EDITOR'S NOTE: Media can access high-resolution images of Spectrum™ by LG in the Verizon Wireless Multimedia Library at www.verizonwireless.com/multimedia. For additional information about Spectrum by LG, please visit and www.SpectrumbyLG.com and www.lgmobilephones.com.)
About Verizon Wireless
Verizon Wireless operates the nation's largest 4G LTE network and largest, most reliable 3G network. The company serves 107.7 million total wireless connections, including 90.7 million retail customers. Headquartered in Basking Ridge, N.J., with nearly 83,000 employees nationwide, Verizon Wireless is a joint venture of Verizon Communications (NYSE, NASDAQ: VZ) and Vodafone (LSE, NASDAQ: VOD). For more information, visit www.verizonwireless.com. To preview and request broadcast-quality video footage and high-resolution stills of Verizon Wireless operations, log on to the Verizon Wireless Multimedia Library at www.verizonwireless.com/multimedia.
About LG Electronics, Inc.
LG Electronics, Inc. (KSE: 066570.KS) is a global leader and technology innovator in consumer electronics, mobile communications and home appliances, employing more than 93,000 people working in over 120 operations around the world. With 2010 global sales of 55.8 trillion Korean won (USD 48.2 billion), LG comprises four business units: Home Entertainment, Mobile Communications, Home Appliance, and Air Conditioning & Energy Solutions. LG is one of the world's leading producers of flat panel TVs, mobile devices, air conditioners, washing machines, and refrigerators. LG has signed a long-term agreement to become both a Global Partner and a Technology Partner of Formula 1™. As part of this top-level association, LG acquires exclusive designations and marketing rights as the official consumer electronics, mobile phone and data processor of this global sporting event. For more information, please visit www.lg.com.
About LG Electronics Mobile Communications Company
The LG Electronics Mobile Communications Company is a leading global mobile communications and information company. With its cutting-edge technology and innovative design capabilities, LG creates handsets that provide an optimized mobile experience to customers around the world. LG is pursuing convergence technology and mobile computing products, while continuing its leadership role in mobile communication with stylish designs and smart technology. For more information, please visit www.lgmobilephones.com.
Spectrum by LG
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Andrew, Just a few words of my appreciation for the hard work and dedication you demonstrated while representing me for the sale of my condominium townhouse. As you know I had attempted selling privately, and was unsuccessful. After meeting with you, I had all the confidence in the world that you would do a great job, and you did! You went above and beyond my expectations in selling my unit in less than a month at a good price in a market where other agents and their clients were offering a substantially reduced asking price. So, thank you and you can rest assured that I will highly recommend your services to everyone I know!


Same day loans can save your day. These are quick-fix solutions that you can use for emergency expenses such as payment for medical bills, grocery items, tuition fees and car repair.
Lending facilities have grown rapidly so you have the prerogative of choosing one that gives the most reasonable terms. However, majority of these private lenders have identical terms and rates for all borrowers. The finance charges of high-risk lenders are relatively higher than banks, cooperatives and traditional lending companies.
The loans with no credit check are processed faster than other ordinary loans. Nevertheless, you have to be familiar with the specific steps so you will know what to expect. Initially, you have to pick out the lender which you feel will give the most evenhanded terms. You can check their websites online or call each one to determine the offers, terms and rates of each. Once you have identified your lender, inquire about the requirements and documents that you need to fill up. Processing is the same for all loan amounts. The documentation part may be the most complicated and lengthy.
Upon completion of the application for your cash advance, you can already negotiate for the funds you need. Inquire about the smallest details before finalizing your loan. Do not allow the lender to have access to your bank accounts or any asset that you have. Find out the exact amount that you have to settle including all fees and interest rates. Avoid borrowing more than the amount you need. The monthly interest rates are really sky-high so you may end up returning twice the amount that you borrowed.
Acquiring an instant payday loan is full of risks. It is better not to push through with this loan if you are not capable of paying it back on time. Since this is a high-rick loan without any collateral, the interest charges and penalty will go up in case of default. This will only add to your financial predicament. Make it a point to settle your loan upon receiving your paycheck and reimburse the entire amount plus all interest fees. Check the background of the lending facility before consummating your loan. Responsible lending entities put in all useful information in their websites. These companies should have built a solid reputation for being prompt in responding to existing clients and potential borrowers. Be wary of companies which may simply take advantage of your cash-strapped condition. This short-term payday loan is not a long-term solution that is why the settlement term is limited to 30 days with a grace period of up to three months.
If you do not want to be compromised with the sudden loss of financial stability, be smart enough to plan your finances carefully. Create a daily and monthly budget for domestic necessities, school expenses, medical requirements and miscellaneous items. Likewise, make an effort to generate a small amount of savings. This will help you stay away from unnecessary borrowing such as same day loans.
Are Same Day Loans Safe?


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Olá, o meu nome é Clara, estou aqui para vos ajudar a obter uma tradução de qualidade.
Clara - Leiria, Portugal
Portuguese (Portugal) (Native)
Caldas da Rainha was part of the ancient region Lusitania, inhabited by ancient Romans who took advantage of sulphurous waters sprouting in the region. Barbarian invasions destroyed most of the Roman-built baths. By the 13th century, the springs were known as "caldas de Óbidos", after the nearby town. At this time, a Benedictine order looked after the needs of the poor and cared for the lepers and rheumatics, who sought the healing waters. With the disbandment of the order by the 15th century, the area fell into disrepair.[14]
Queen Leonor (Rainha Dona Leonor, in Portuguese), the wife of King João II, is credited as the founder of Caldas da Rainha.[1] One day in 1484, while traveling from Óbidos to Batalha, she happened upon a group of peasants bathing in foul-smelling waters by the roadside. The queen stopped to inquire about this oddity, and the bathers told her that the waters possessed curative powers. She decided to try them and was pleased to find that she was quickly relieved of an unknown affliction that she had been suffering. On that site, the queen ordered a hospital built so that others could enjoy the same relief.[15] Construction began the following year, and although the first patients were admitted in 1488, the works were not completed until about 1496 or 1497. To finance the hospital and its adjoining church, the queen sold her jewels and used income from her landholdings.[14] The name of the settlement that grew around the site and became Caldas da Rainha refers to both its founder and the reason for its existence. The city's name can be translated as "Queen's Hot Springs",[16] "Queen's Spa",[17] or "Queen's Baths".[18] The settlement's waters remain its major claim to fame.[19]
On 21 March 1511, King Manuel I, brother of Queen Leonor,[1] conferred the status of town (vila) upon Caldas da Rainha.[20] In 1821, it was made a municipality (concelho or município).[21]
Medical/Pharmaceutical
Universidade Europeia
Faculty/Department: Translation + Business Administration
Degree Obtained: PhD

redpajama_set_name: RedPajamaCommonCrawl


Beautiful Hanauma Bay along the south-east coast of Oahu.
I consider Hawaii my home away from home. I always tell people that if I'm not living in Vancouver, I would be living in Hawaii. I love the laid back life style and the close proximity of the sun and ocean life. Hawaii, in a way, reminds me of Vancouver. The culture is very diverse. Besides Hawaiians living there, there are many other nationalities living there like the Japanese, Filipinos, Koreans and Chinese! Actually, I find Honolulu very much like Vancouver. Vancouver has many different nationalities living here, too. Hawaii is also a haven for multicultural food. Plenty of Japanese and Korean restaurants to choose from as well local Hawaiian cuisine and, of course, since it's a part of America, you can find your standard American food as well. Right on the Waikiki strip is a Cheescake Factory with normal wait times of an hour. I was told that this location is one of the busiest ones across all the states in the USA. I discovered many restaurants in Hawaii where there is a crossover of foods, like Hawaiian meals with a Chinese flair. I especially appreciated the many unique Japanese stores and restaurants that I don't see here in Vancouver. I only recently discovered Don Quijote. It's like a cross between a Walmart and a Japanese supermarket. I had a fun time browsing the aisles and checking out the Japanese goods that are not available here in Vancouver. There are actually quite a few Japanese speciality shops in Honolulu. I guess there is a market for it in Hawaii with a visibly large Japanese population and with so many visiting Japanese tourists. There are many Asian influenced stores even at the Ala Moana Center which is Honolulu's largest shopping mall. I bought some tea and a cute tea jug from a Japanese tea store there. I also found some Korean beauty products at the center as well.
Hanging at the beach in Waikiki.
Aliionlani Hale - Hawaii State Supreme Court. The famous King Kamehameha statue.
The gates leading into Iolani Palace - royal residence of ruler of Kingdom of Hawaii.
Lovely intricate details outside Iolani Palace.
This time during my stay in Honolulu, I visited Iolani Palace which was the royal residence for the rulers of the kingdom of Hawaii beginning with King Kamehameha III and ending with Queen Lili"uokalani. I was very impressed with many of the intricate details that went into the building of the palace including the intricate woodwork on the staircase and other areas of the palace. It's been preserved as best it could and was renovated in 1978 and was opened to the public to give visitors an idea of what life was like for the Royal Hawaiian family back in the day. Check out my photos for more on the palace. I also visited Chinatown for the first time on this trip. I didn't have time to stop and eat though. Maybe next time. I also went snorkelling at famous Hanauma Bay. It's one of the most popular tourist spots on the Island. On the day I went, there was a long queue waiting to pay to get in. The reason for it's popularity is the snorkelling and the colourful fish within this protected coral reef. I did see many different types of fish and also got incredibly sun burnt that day! No stop in Honolulu is complete without a couple of beach days on Waikiki Beach with Diamond Head in the background. Even though Waikiki Beach is man made, it didn't seem to bother the marine life. It was super fun to see a turtle pop it's head up next to the swimmers. I stayed in a hotel that had a really good view of the fireworks which takes place every Friday night at the Hilton Hawaiian Village. I've seen many fireworks shows in my time, but, never this close and from my lanai. It was really loud but fun.
Hanging out at Waikiki Beach with Diamond Head in the background.
I stayed in a hotel with a room with a view. I was also able to catch the fireworks display that takes place every Friday night. I don't think I've ever been that close to a fireworks show before.


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Rutgers, the State University of New Jersey -- Honors College
Miami Shores, FL
Alma Maters of Musicians
The Experts' Choice: Unexpectedly Strong Science Programs
Community Colleges Enrolling a Large Number of Hispanic Students
Winning Women's Division III Volleyball Teams
Fund for American Studies Internships
Sponsored by: Fund for American Studies
There are programs in comparative political and economic systems, political journalism, business and government, philanthropy and international institutes. Each program includes classes, an internship and special events. Students live in on-campus housing at George Washington University or in furnished apartments in the Capitol Hill neighborhood. Each student takes 3-9 credit hours in courses at George Mason University in addition to interning 30-35 hours per week. Summer and school-year programs are available.
Peter Van Emburgh
Fund for American Studies
https://tfas.org/awards/
Fund for American Studies sponsors 2 more scholarships
Collegiate Journalism Award
Fund for American Scholarship
1621 New Hampshire Avenue, NW
admissions@tfas.org


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Letter: A "yes" vote on 3B benefits local schools
As a teacher, a parent and a community member of Glenwood Springs, I ask all voters within the Roaring Fork School District to vote "yes" on 3B this fall. I attended Glenwood Springs Elementary School as a child, my children attend school in this community and I am honored to teach at the elementary school. While the school where I teach has certainly received a lot of attention for the huge rebuild we will receive when the bond passes, today I'd like to share with you the importance of the middle school renovations in all three communities.
My daughters just completed three years at Glenwood Springs Middle School. Like Carbondale and Basalt middle schools, Glenwood Springs Middle School is one of the oldest unchanged buildings in the district. It is dim and cramped with narrow, dark hallways. In addition, some classes are held in modular buildings that are in need of repairs. Educational research shows that adolescents, particularly at the middle school age, benefit from learning spaces that are built for community, designed with a "heart" at their center. The bond will allow for all three of our middle schools to have modest redesigns that optimize the environment for the adolescent brain. In addition, all three will receive energy efficiency upgrades.
Now, my daughters attend Glenwood Springs High School. In the bond, the high school will receive a remodeled performance art space. Basalt High School, along with support from the Basalt community, plans to build a small performance space as it currently has no auditorium. Carbondale Community School will receive a learning lab.
We are fortunate to live in a country where public education is available for all children. I believe we, as a community, have a responsibility to provide not only high quality instruction, but also facilities that are safe and optimal for learning. These are just some of the projects our communities will receive that will greatly enhance education for our students, if the bond is passed. Please join me in voting "yes" on 3B this fall.
Kim Worline


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You are here: Home / *Articles of the Bound* / Hillary's Hybrid Warfare
Hillary's Hybrid Warfare
March 25, 2019, 5:15 pm by Denise Simon Leave a Comment
By: Denise Simon | Political Vanguard
You have to wonder if Obama is walking with Hillary in the woods pondering another chapter of 'What Happened'.
While we wait along with Congress, under this transparency thing for the full or semi-full disclosure of the Robert Mueller investigation report, we have countless other items that we have already learned that cannot be overlooked.
While we are told the Mueller operation cost the taxpayers upwards of $25 million, and we should be angry that those dollars were wasted, my argument here is that money was well spent. The Mueller report could be a cheap buy to re-elect Trump – the operative word being 'could.' Why? Those among the hundreds interviewed by the Mueller operation told us so much we did not know. Consider a few names such as Corsi, Priebus, Spicer, Clovis, Papadopoulos, Kaveladze, Sessions, Flynn, Hope Hicks, Pompeo and perhaps Michael Caputo. Cheap money to learn about their Mueller adventure(s).
For now, let's set that aside to consider the following:
What have we learned in this agonizing two-plus-year process?
We now know which media had direct channels to politicians and DC lawyers as well as PACs. We know how spin(talking points/commentary) was crafted, giving us a fractured national landscape that has not been seen since the run-up to the Civil War.
We have learned volumes about members of both houses of Congress such that we have much to reconsider during election cycles especially when it comes to Adam Schiff, Maxine Waters, and Jerry Nadler to name a few. Hey Pelosi, what posture statements will you craft now on those people along with Swalwell, Lieu, or Jayapal and countless others?
We have learned that the top floor at FBI headquarters had major investigations scandals that included former Director Comey, McCabe, Strzok, Page, James Baker, Bill Priestap, Mike Kortan, David Laufman, and James Rybicki, to name a few.
We learned about the FISA court warrant applications and how the disclosures of full facts were omitted, demonstrating that new rules with regard to document disclosures must be put in place.
We learned about a tarmac meeting and the panic ensuing that included Secret Service, the FBI, and with emphasis on the Department of Justice to control the damage of the clandestine meeting between DOJ AG Loretta Lynch and Bill Clinton.
As a result of the Benghazi investigation, by the special House Commission, we learned about Hillary not using a government email because she used a private server during her time as Senator and her time as Secretary of State. We learned there is some quasi-investigation on all things Hillary being performed by John Huber appointed by Jeff Sessions. The clock still ticks on that item.
We learned of a pile of text messages, while most were deleted between Strzok and Page as well as McCabe, and the real private political thoughts regarding voters, Republicans, extramarital affairs and investigation chaos including Anthony Weiner/Huma Abedin's electronic devices.
We learned about unmasking by Samantha Power, the Obama White House, James Clapper, and John Brennan. There is still much more to uncover there. Perhaps some extra clues will be in the Mueller report or the next Horowitz IG report.
We learned about the Foreign Agent Registration Act abuses. We learned about who is taking big money representing and from foreign government/rogue operations including Russia, Turkey, Ukraine, China, and even Great Britain. (In addition to registering retroactively as a foreign agent for Ukraine, Skadden agreed to pay the U.S. government more than $4.6 million as a civil penalty, representing the amount the firm received for its work for Ukraine.) We learned about Michael Cohen, Paul Manafort, Rick Gates, Senator McCain's Aid and the dossier and the International Republican Institute.
We learned more about the work of the Podesta Group, Fusion GPS, the DNC, Donna Brazile, Christopher Steele, Glenn Simpson, Perkins Coie, Marc Elias, and media connections and leaks. (Sidebar: Marc Elias is now the lawyer of record for the Kamala Harris 2020 presidential campaign).
We learned about some pit-bull lawyers like Jeannie Rhee, Andrew Weissmann, Michael Dreeben on the Mueller team and we learned that Gregory Craig, an Obama White House lawyer, may be indicted himself.
We learned that the Department of Justice under Obama/Loretta Lynch directed the FBI regarding countless investigative cases per testimony by both Strzok and Page. Time for Loretta Lynch to be questioned again.
We learned about how far and wide Congressman Adam Schiff will go on his search and destroy mission with all things Russia and Trump. He participated in a hoax Russian phone call, he met privately with Glenn Simpson and how Schiff is so angry about the Mueller report already, which he does not even have in his possession, much less has read, that he wants to subpoena Mueller and perhaps some of the team lawyers. We have also learned that many 2020 presidential candidates are fundraising off the Mueller report…sheesh.
That is hardly a complete list and the reader may well be able to add to that list. After 675 days of a national nightmare, it is not over yet. The burden is now on the new AG, Bill Barr. There will be no further indictments per Robert Mueller but keep a close eye on the Southern District of New York – their work is not complete at all.
There was no collusion. There was no conspiracy, but hold on….who is enjoying this most of all?
Vladimir Putin. It cannot be denied that Moscow did infect our politics and elections and continues to do so. We have witnessed the depths of the dirty operators in our country and beyond our country.
We cannot overlook the likes of Sidney Blumenthal, Lanny Davis, Senator Mazie Hirono, Cody Shearer, Cheryl Mills, David Kendall, or Michael Sussman. We cannot forget the deep ties we discovered like Bruce Ohr and his wife, Nellie Ohr, Joe Biden and his China/Ukraine connections, Sergei Kislyak, those of the operatives in the Clinton Foundation and, oh yeah, Terry McCauliffe (a big Clinton fixer).
In summary, perhaps the cost of the Mueller team investigation was worth $25 million, we learned so much when it comes to conspiracy, connections, the malfeasance of the top floor of the FBI and the Department of Justice. There is so much to examine and fix. President Trump could very well be in a good place if handled well going into 2020 for re-election if he can play tactical political chess.
Meanwhile, Hillary is still taking her walks in the woods….what happened….indeed.


We are currently recruiting a Lead EC&I Engineer for our client based in Warrington, who are a service provider to industrial companies across the UK. They are currently involved in an exciting, long-term petrochemical project and are seeking a staff EC&I lead to manage the project deliverables.
Selection & specification of general items of equipment e.g. converters, barriers, indicators, relays, junction boxes, cables etc.


How to watch Titans: Season 1: Donna Troy on Netflix Portugal!
Yes, Titans: Season 1: Donna Troy is now available on Portuguese Netflix. It arrived for online streaming on January 11, 2019.
We'll keep checking Netflix Portugal for Titans: Season 1: Donna Troy, and this page will be updated with any changes.


In the United States, over 20,000 women will be diagnosed with ovarian cancer each year – enough women to fill the Galen Center twice – and is the leading cause of death among female reproductive systems cancers. Ovarian cancer receives less publicity, funding, and research than other forms of cancers, leaving many women feeling frustrated or hopeless.
When a woman is diagnosed with recurrent ovarian cancer, she sits with her doctor and receives a menu of treatment options and is asked to select their preferred method: chemotherapy, surgery, or possibly immune therapy. Doctors can guide the decision, but finding the correct sequence and combination is a process of trial and error that can take a long time. Time that can often be toxic to a patient.
This process is different in other more represented cancers like breast cancer, where doctors make targeted decisions on a treatment plan based on the tumor size and individual patient needs. Ovarian cancer patients do not have the same kind of personalization options.
The USC Information Sciences Institute's Greg Ver Steeg and Shirley Pepke have discovered a way to change that.
In their paper, "Comprehensive Discovery of Subsample Gene Expression Components by Information Explanation: Therapeutic Implications in Cancer," Pepke and Ver Steeg have discovered a new method of finding gene groups with related expression levels. Some of these groups are strong predictors of long term survival and some can be targeted with existing drugs.
Ver Steeg, a research professor in USC Viterbi's Department of Computer Science, believes "this presents several exciting new avenues for ovarian cancer treatment." Most notably, patients may have the ability to create personalized treatment plans based on their gene expression.
"We can assess the tumor and see what is driving it to behave this way," Pepke said.
Pepke and Ver Steeg certainly have a connection to ovarian cancer's reach and the effect it has on patients. Pepke was studying gene expression with researchers at Caltech when she herself was diagnosed with ovarian cancer.
Her diagnosis came at a time when her two children were just 9 and 3 years old, and they are a major motivator in her research. "I am sure every parent can understand how devastating it is to be forced to plan for their children growing up without them," Pepke said.
In the wake of her diagnosis, Shirley sought out a colleague who could help her to analyze her expression data using machine learning. Kristina Lerman, also of USC ISI and the Department of Computer Science, connected her to Ver Steeg who has been doing work in the field of machine learning and already had an algorithm in place that could help Shirley analyze her data.
"I had an algorithm that helped explain high dimensional data, but I didn't have the background in biological applications," Ver Steeg said. So, with his background in machine learning and Pepke's in gene expression, their work began.
Using this algorithm and ovarian cancer patient data from public databases, Ver Steeg and Pepke found patterns in the gene expression data and discovered that certain gene groups could respond positively to existing drugs; information that can one day help patients create custom treatment plans.
Pepke believed that their method and Ver Steeg's algorithm was so helpful, she used it in determining her own treatment plan when her cancer returned.
"I wouldn't recommend that anyone do this," Pepke warned, "but I analyzed my own tumor's gene expression." Analyzing her own cancer data, she found that her gene expressions were connected to her immune system and developed a targeted treatment plan focused on immune therapy.
"It was not what was recommended to me," Pepke remembered, but it worked well and she has been in remission for one year. While her doctors cannot say for sure that knowing her expression patterns directly led to her remission, knowing these patterns did guide her to a more educated decision.
Ver Steeg says that their findings go beyond ovarian cancer; their use of machine learning to analyze biomedical patterns can be applied in analyzing other cancers as well as neurological conditions such as Alzheimer's.
The duo's hope is that more work can be done, and experts in the area can research further to one day develop a set of tools and a framework for doctors and patients to analyze individual data directly.


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Acupuncture performed before and after embryo transfer improves pregnancy rates.
Youran D et al
Objective: Conflicting evidence exists on whether acupuncture is beneficial for patients undergoing In Vitro Fertilization (IVF) cycles. Therefore, this study was undertaken to determine whether on-site acupuncture, performed both before and after embryo transfer, affects clinical outcomes.
Design: Retrospective data analysis.
Materials and Methods: The Acupuncture Group consisted of 49 patients who received acupuncture on-site before and after embryo transfer in 2007. The treatment did not follow the Paulus protocol. The Control Group were 212 patients with no acupuncture undergoing IVF cycles in the same time period. The data was subdivided by SART age classifications to determine if acupuncture differentially benefitted certain age groups. Clinical Pregnancy Rate (CPR) was defined as the presence of fetal cardiac activity. Loss Rate was the percentage of pregnancies that did not proceed from a positive hCG to a clinical pregnancy. Data were analyzed using the unpaired t-test and Fisher's exact test, with significance defined as P < 0.05.
Results: Patients with a positive hCG were significantly higher in the Acupuncture Group for women less than 35 years old (63.3% vs.43.2%, p 1⁄4 0.048). The Acupuncture Group also had a higher CPR in the under 35 category (60.0% vs. 34.6%, p 1⁄4 0.01). There were no differences in the other age groups. Combining all the age groups, the cycle parameters between the two Groups were equivalent, while the CPR was higher and the Loss Rate lower for the Acupuncture group
Conclusions: Although other studies regarding acupuncture have been inconclusive, perhaps these positive results are related to two important factors. The treatments were performed on-site, eliminating the stress of traveling to another site before and after the embryo transfer. Also, the acupuncture treatment protocol did not follow the traditional Paulus protocol, thereby suggesting there is still more research to be done on how best to treat infertility issues with acupuncture.


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DE F09 ADV Games
October 6, 2009 / Julia
Conversation Class Lesson Plan
Section: Advanced Conversation
Date: 6. Oktober 2009
Class theme/topics discussed: Sprachspiele
How did you pick this theme or topic?
We wanted to keep working on our project, but since I had been sick and the FLRC was booked this week, we decided to spend one week playing different word and language games.
How did you present the material? (handouts, group work, general discussion, student presentations, etc.)
At first, I asked my students what kind of German games they knew. Then I told them about different language games and exercises and asked them which ones they would like to play. We agreed on "Stadt, Land, Fluss", "Kofferpacken" and learning some "Zungenbrecher". So we played "Stadt, Land, Fluss" for the most part of the lesson, spent about 10 minutes on the second game and then for the last 5 minutes we learned some funny tongue-twisters.
How did students react?
The students were very excited about the games. We had a lot of fun playing the different games and learning German tongue-twisters.
Did they engage with each other and you?
Yes, they did. They were talking very much and they asked a lot of questions about vocabulary.
What materials or media did you use? (articles, satellite tv, digital projector, etc.)–
Would you recommend this activity for a future class? Why or why not?
Yes, it was a nice break from the other lessons. The students enjoyed playing games and were quite competitive.
Advanced, Communication, Games and Ice-breakers, German, Intermediate
GamesTongue-Twister
FR F09 INT/ADV – Food (cooking utensils)
CN F09 ADV Nobel Prize


text:
The St. Vincent's Foundation Team
2018 Business and Financial Summary
Income & Grants Policy
Donor & Fundraising Details
Statement of Compliance with Guiding Principles for Fundraising
Data Protection Policy and GDPR
Donate a Gift
Leave A Legacy to St. Vincent's
Organise or Take Part in A Fundraising Event
Sponsored & Fundraising Events
Donor's Newsletter
Projects Supported By Donors
Historic Photos 1
Historic Photos 10
HomeFundraiseOrganise or Take Part in A Fundraising Event
Fundraising events can be very enjoyable as well as a great means of contributing to a worthy cause. There are hundreds of events that might be attractive.
If you are looking for ideas on what to organise why not get our list of ideas by going to our Fundraising Ideas page.
You could also look at the list on our partner site www.MyCharity.ie for ideas and to set up a sponsorship page.
Remember you can nominate the cause you are fundraising for within St. Vincent's.
Do you want to consider running something like a concert or a dance for a cause within St. Vincent's in your own area?
If you want to promote an upcoming event for St. Vincent's please let us know! Send us the details and we will add it to our list.
Registered in Dublin, Ireland. Company Registration No. 464228 Charity No. 1183
Registered Office: St. Vincent's Foundation, Elm Park, Dublin 4, D04 T6F4
T: +353 1 221 5065 F: +353 1 221 4428
Donation Tel. No. 1850 603 803
Get involved with events in aid of St. Vincent's Foundation
St. Vincent's Foundation complies with The Principles of Good Governance and with The Statement of Guiding Principles for Fundraising. See ICTR for details of the principles.
© 2020 St. Vincent's Foundation. All Rights Reserved


text:
Album by Lady Gaga
The Fame is the debut studio album by American singer Lady Gaga. It was released on August 19, 2008 through Interscope Records. After joining Kon Live Distribution and Cherrytree Records in 2008, Gaga began working on the album with different producers, primarily RedOne, Martin Kierszenbaum and Rob Fusari. Musically, The Fame is a synthpop and dance-pop album that has influences of pop music from the 1980s. Lyrically, the album visualizes Gaga's love of fame in general while also dealing with subjects such as love, sex, money, drugs and sexual identity. Promotion was primarily through The Fame Ball Tour and multiple television appearances. The Fame was included as a bonus disc on the deluxe edition of the extended play, The Fame Monster (2009).
Studio Album
Record Plant and Chalice Recording Studios (Los Angeles, CA)
Cherrytree Recording Studios (Santa Monica, CA)
150 Studios (Parsippany, NJ)
Poe Boy Studios (Miami, FL)
333 Studios and Dojo Studios (New York, NY)
New Road Studios
# of tracks
Kon Live
Brian & Josh
Rob Fusari
Martin Kierszenbaum
Partying · In Love · Sex · Empowering · Club · Girls Night Out · TGIF · Late Night · Cool & Cocky
Again Again
Song by Lady Gaga
Eh Eh (Nothing Else I Can Say)
Summerboy
sweetangel666
Evitamarie
wdweditorial
1 connection
ARTPOP
This page is the FamousFix profile for The Fame. Content on this page is contributed by editors who belong to our editorial community. We welcome your contributions... so please create an account if you would like to collaborate with other editor's in helping to shape this website.
On the The Fame page you will be able to add and update factual information, post media and connect this topic to other topics on the website. This website does skew towards famous actors, musicians, models and sports stars, however we would like to expand that to include many other interesting topics.


Find Mr Fantastic Standard Costumes Halloween shopping results from Amazon & compare prices with other Halloween online stores: Ebay, Walmart, Target, Sears, Asos, Spitit Halloween, Costume Express, Costume Craze, Party City, Oriental Trading, Yandy, Halloween Express, Smiffys, Costume Discounters, BuyCostumes, Costume Kingdom, and other stores.
Standard costume includes: character inspired jumpsuit with reflective strip detail trim on front and around both arms.
Morris Halloween Costumes;Character inspired jumpsuit with reflective strip detail trim on front and around both arms. Child size 46.
Don't satisfied with Mr Fantastic Standard Costumes results or need more Halloween costume ideas? Try to exlore these related searches: Duster Coat Costume, Peter Griffin Costumes, Boba Fett Costume With Jetpack.


text:
E-moped commuters in Solihull trial getting to work quicker and cheaper
by Alex Bowden Nov 30 2022
E-motos.jpg, by Solihull Council
Cost of charging "almost negligible" compared to prices at the fuel pump
Last year Solihull Council partnered with local e-moped dealer Silence UK to offer commuters from Dickens Heath the chance to test one. After an initial taster session, people were given the option of an extended, free trial to see how commuting by e-moped would work for them in practice.
The scheme is part of the council's low carbon future mobility project and is an effort to show how electric mopeds can reduce both carbon emissions and the number of single-occupancy cars on the road.
Councillor Andy Mackiewicz, Cabinet Member for Climate Change, Planning and Housing, commented: "We know that 39 per cent of all carbon emissions in the borough are currently attributable to transport, with road traffic accounting for nearly all of this. Making the switch to electric vehicles, including e-motos is going to be an essential part of our journey towards net-zero."
> The best electric mopeds you can ride on an AM licence
Around 80 per cent of those who took part in the taster session said it had made them consider how they get around and the majority felt they would be able to replace up to half their car journeys.
One person who took up the offer of a longer trial was Nick Chadaway who sometimes works from home but otherwise commutes to Digbeth in Birmingham by car.
Chadaway said he'd really enjoyed using the e-moped and that his journey times had been noticeably quicker.
"Before taking part in this trial and taking my CBT (Compulsory Basic Training) I had never thought about using an e-moped, but it was very easy to pick up and just a lot of fun to ride.
"Another positive thing to come out of the experience is that I feel like it's helped to make me a better driver when I'm in the car. Although I felt safe, riding an e-moped forces you to think ahead a lot more and really look for potential hazards on the road.
"I'd definitely consider getting one of my own, but in the meantime it's made me think about my overreliance on the car and encouraged me to dust off the old push-bike for some commuting in the better weather."
> 5 of the best electric mopeds
The average running cost of an e-moped is just 1p a mile and Chadaway really noticed a difference in that area too.
"Despite energy bills going up, the cost of charging my e-moped at home was almost negligible compared to prices at the fuel pump and even switching vehicles for just three weeks has saved me some significant money," he said.
Councillor Ken Hawkins, Cabinet Member for Economy and Infrastructure, said: "I'm really pleased that residents like Nick have had the opportunity to give the e-mopeds a go and I'm encouraged to hear that the experience has been such a positive one.
"Electric mopeds clearly have wide applications for couriering smaller items and food delivery but they also offer a clean, practical and affordable means of personal transport, and crucially an alternative to many shorter car journeys.
"This project is all about giving people the opportunity to try something different and see if they can be encouraged to leave the car at home. E-motos have the potential to cut congestion, improve air quality and, as we have seen, save commuters money."


Who doesn't want everything they love at their fingertips? At Modera Jackson, that's exactly what you get. On-site amenities include a state-of-the-art fitness studio, a posh theater and media room, an expansive outdoor courtyard, common and private resident patios, flex-work areas and a community clubroom, just to start.
No other community comes close to the experience you'll have at Modera Jackson. Top to bottom, quality permeates our community. Stand atop our rooftop deck and take a few minutes to appreciate the beauty of the views surrounding you. When you've had your fill of the mountains, the city, the Puget sound, and the fresh air, kick back in our rooftop clubroom and socialize with fellow residents or friends.
The experience at Modera Jackson is one you'll not forget. Coupled with everything Seattle has to offer, you'll quickly see why so many residents are proud to call Modera Jackson home. Give us a call to schedule your own in-person tour.


At DumpsterZone, we strive to bring you the best service at the best price available. We have a wide selection of dumpster sizes in stock in Slab Fork, WV, with flexible & timley pickup and delivery. Give us a call today for all your dumpster rental and roll off needs.
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Utilize a smaller provider. Big Box companies charge major rates, generally because you happen to be paying for their particular national marketing strategy every time you create them a cheque. Smaller companies do their particular business along with marketing on the smaller size, which means they must be able to provide you with a better cost on your junk Dumpster for Rent in Slab Fork, WV.
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Compulsive hoarding is seen as a the inability as well as unwillingness to get rid of trash with the home, even if the items getting kept have zero value, are generally unsanitary, as well as actually hinder on the sufferer's ability to carry out everyday duties. Social interactions, professional goals, mobility in the house, and even daily necessities such as cleaning and preparing can be made complicated or unattainable by the abnormal amounts of hoarded trash. Beating this condition requires health-related intervention along with counseling, in addition to moral support from members of the family and other loved ones. Before these steps might be fully understood, however, it is very important first be sure that the living area you want is completely cleaned of all unnecessary garbage, specifically any things that may be directly threatening private safety as well as posing a life threatening risk towards the property. So as to take that vital stage, hoarders may require the assistance of a professional trash hauling business.
The weather estimate may be with rain as well as snow and you need to get your roof job done over the following few days. Thank goodness you can get your supplies easily such as the shingles for the roofing and a dumpster the next day.
You need to know the kind of services any dumpster company gives before renting any dumpster. Many dumpster corporations perform roll-off-services, that is a good way of getting loads of do the job done without worrying about where the rubbish will go. An organization using roll-off solutions will take absent the dumpsters along with replace all of them new ones anytime it will be needed. In addition, many organizations use the large dump vehicles to get rid of the waste materials collected in the dumpsters leaving vacant dumpsters to be used. If you a businessperson and you generate a lot of waste materials, you will definitely wish to be in agreement that has a Dumpster for Rent in Slab Fork company. By doing this, you will end up conserving your business a ton of money.
Your living room is your getaway and you may perform a lot of work with there. Once in awhile you may wish you had room for a comfortable oversized leather couch. If you decide to remodel your living room, than this can be achieved so that you are pleased with your living room.
How long does one get to keep your dumpster? Most companies will help you to keep your dumpster intended for between 5-7 days and nights. If you're lucky, you might find a corporation that will let you keep your dumpster for about 2 weeks. What happens if you want to ensure that it stays longer than your agreed timeframe? Extra fees. Normally, you will get in a daily rate charge from any place from $5 for you to $15 per day, following the initial rental time.
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While benefit is definitely a gain, there are a few more important positive aspects to using a Dumpster for Rent in Slab Fork, WV services. First, the operation of waste convenience often is actually regulated. Particular sorts of waste require to be extracted in extremely specific methods. By using a dumpster services, this turns into much less of the concern to the business as well as home owner included. In addition to in which, renting or maybe buying a truck is often essential for those who attempt to get rid of their own garbage. This is not only another cost, yet takes time and energy to do.
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A dumpster are a wide container, and that is mostly consisting of steel as well as plastic. These are generally used for the particular temporary safe-keeping of litter and it can be useful for disposing the garbage generated in your house renovation as well as construction task hassle free.
If you aren't going to recycle the baseboards in your your kitchen when you are during remodeling, you'll be able to throw all of them into the dumpster also.
The first thing that you should do is consider your individual requirements. Sometimes, big businesses will be needing extremely substantial dumpsters that are capable to be rolled away by a truck. When the truck rolls most of these large dumpsters apart, it simply leaves a new one that is completely bare and ready to the businesses' refuse.
Mind you: if you haven't used it in over a year, it's rubbish and you do not require it in your daily life.
First, pick the correct dimension dumpster. The most common styles include the 10 yard container, Something like 20 yard container or 25 yard bins. A 10 yard container is needed for most household remodeling initiatives and doesn't occupy too much room in your yard. The particular 20 yard container is needed for smaller residential or commercial initiatives. A 25 yard container is for channel to large initiatives. Make sure that you pick the correct dimension for your task. Even though you may well save money by renting the smaller dumpster, you may pay when you have to schedule numerous pick-ups to haul the garbage away. To be secure, you should never excess your dumpster mainly because it can be very unsafe for the car owner hauling apart your rubbish if it's beyond capacity.
Landscaping as well as Yard Spend: Spring as well as fall yard clean-up activities can easily generate a large amount of waste. With regard to convenient convenience, use a dumpster to get rid of debris through pruning, shaping, mowing, shrub removal, rock and brick projects, sod, tree stumps, and many others. Debris might be more effectively was comprised of inside the dumpster as well as removed prior to wind can transport it back to your own yard.


text:
<?php

namespace MusicBundle\Controller;

use Symfony\Component\HttpFoundation\Request;
use FOS\RestBundle\Controller\FOSRestController;
use Sensio\Bundle\FrameworkExtraBundle\Configuration\Method;
use Sensio\Bundle\FrameworkExtraBundle\Configuration\Route;
use JMS\Serializer\SerializationContext;

use MusicBundle\Entity\Playlist;
use MusicBundle\Entity\User as User;
use MusicBundle\Form\PlaylistType;

use FOS\RestBundle\Controller\Annotations\Get;
use FOS\RestBundle\Controller\Annotations\Post;
use FOS\RestBundle\Controller\Annotations\Delete;
use Nelmio\ApiDocBundle\Annotation\ApiDoc;

/**
 * Playlist controller.
 */
class PlaylistController extends FOSRestController
{

    /**
     * Display all the Playlists.
     *
     * @ApiDoc(
     *  resource=true,
     *  description="Find and display an Artist entity.",
     *  statusCodes={
     *       200="Returned when successful",
     *       401="Returned when the user is not authorized to say hello",
     *       404={
     *         "Returned when the user is not found",
     *         "Returned when something else is not found"
     *       }
     *   }
     * )
     */
    public function getPlaylistsAction()
    {
        $em = $this->getDoctrine()->getManager();

        $context = SerializationContext::create()->setGroups(array('playlist_list'));

        $playlists = $em->getRepository('MusicBundle:Playlist')->findAll();
        $view = $this->view($playlists, 200);
        $view->setSerializationContext($context);

        return $this->handleView($view);
    }

    /**
     * Find all playlists of an user.
     *
     * @ApiDoc(
     *  resource=true,
     *  description="Find all playlists of an user.",
     *  requirements={
     *      {
     *          "name"="id",
     *          "description"="Id of the user how we want to show all the playlists."
     *      }
     *  },
     *  statusCodes={
     *       200="Returned when successful",
     *       401="Returned when the user is not authorized to say hello",
     *       404={
     *         "Returned when the user is not found",
     *         "Returned when something else is not found"
     *       }
     *   }
     * )
     */
    public function getPlaylistAction($id)
    {
        $em = $this->getDoctrine()->getManager();

        $context = SerializationContext::create()->setGroups(array('playlist_one'));

        $playlist = $em->getRepository('MusicBundle:Playlist')->findOneById($id);
        $view = $this->view($playlist, 200);
        $view->setSerializationContext($context);

        return $this->handleView($view);
    }

    /**
     * Get last playlist generated for user.
     * GET Route annotation.
     * @Get("/playlists/get/last")
     *
     * @ApiDoc(
     *  resource=true,
     *  description="Get last playlist generated for user",
     *  statusCodes={
     *       200="Returned when successful",
     *       401="Returned when the user is not authorized to say hello",
     *       404={
     *         "Returned when the user is not found",
     *         "Returned when something else is not found"
     *       }
     *   }
     * )
     */
    public function getPlaylistLastAction()
    {
        $em = $this->getDoctrine()->getManager();
        $user = $this->get('security.context')->getToken()->getUser();

        $context = SerializationContext::create()->setGroups(array('playlist_one'));

        $playlists = $em->getRepository('MusicBundle:Playlist')->findBy(['user' => $user->getId()], ['id' => 'DESC']);

        $view = $this->view($playlists, 200);
        $view->setSerializationContext($context);

        return $this->handleView($view);
    }

    /**
     * Delete playlist from ID.
     * DELETE Route annotation.
     * @Delete("/playlists/{id}/delete")
     *
     * @ApiDoc(
     *  resource=true,
     *  description="Delete playlist from ID.",
     *  requirements={
     *      {
     *          "name"="id",
     *          "description"="Id of the playlist how we want to delete."
     *      }
     *  },
     *  statusCodes={
     *       200="Returned when successful",
     *       401="Returned when the user is not authorized to say hello",
     *       404={
     *         "Returned when the user is not found",
     *         "Returned when something else is not found"
     *       }
     *   }
     * )
     */
    public function deletePlaylistAction($id)
    {
        $em = $this->getDoctrine()->getManager();

        $playlist = $em->getRepository('MusicBundle:Playlist')->findOneById($id);
        $user = $this->get('security.context')->getToken()->getUser();

        $data = [
            'status' => 0,
            'message' => 'Deleted playlist',
            'deleted_id' => []
        ];

        if(empty($playlist)){
            $data['message'] = 'Playlist doesn\'t exist';

            $view = $this->view($data, 200);
            return $this->handleView($view);
        }

        if(in_array('ROLE_ADMIN', $user->getRoles())){
            $is_admin = true;
        } else {
            $is_admin = false;
        }

        if(($user->getId() == $playlist->getUser()->getId()) || $is_admin ) {
            $data['status'] = 1;
            $data['deleted_id'][] = $playlist->getId();
            $em->remove($playlist);
            $em->flush();
        } else {
            $data['message'] = 'User not allowed to delete';
        }

        $view = $this->view($data, 200);
        return $this->handleView($view);
    }

    /**
     * Delete all playlist for a user.
     * DELETE Route annotation.
     * @Delete("/playlists/delete/all")
     *
     * @ApiDoc(
     *  resource=true,
     *  description="Delete all playlist for a user.",
     *  statusCodes={
     *       200="Returned when successful",
     *       401="Returned when the user is not authorized to say hello",
     *       404={
     *         "Returned when the user is not found",
     *         "Returned when something else is not found"
     *       }
     *   }
     * )
    */
    public function deletePlaylistAllAction()
    {
        $em = $this->getDoctrine()->getManager();
        $user = $this->get('security.context')->getToken()->getUser();

        if(in_array('ROLE_ADMIN', $user->getRoles())){
            $is_admin = true;
        } else {
            $is_admin = false;
        }

        $data = [
            'status' => 1,
            'deleted_playlists' => []
        ];

        $playlists = $user->getPlaylists();
        foreach($playlists as $playlist) {
            $data['deleted_playlists'][] = $playlist->getId();
            $em->remove($playlist);
        }
        $em->flush();

        $view = $this->view($data, 200);
        return $this->handleView($view);
    }

    /**
     * Initiates creation of a new playlist.
     * @param Request $request
     * @return \Symfony\Component\HttpFoundation\Response
     * @ApiDoc(
     *  resource=true,
     *  description="Initiates creation of a new playlist.",
     *  requirements={
     *      {
     *          "name"="name",
     *          "description"="Name of the playlist"
     *      },
     *     {
     *          "name"="soundcloud_user",
     *          "description"="String URL of the targeted soundcloud user"
     *      },
     *     {
     *          "name"="nbr_music",
     *          "description"="nteger Number of songs in the playlist"
     *      }
     *  },
     *  statusCodes={
     *       200="Returned when successful",
     *       401="Returned when the user is not authorized to say hello",
     *       404={
     *         "Returned when the user is not found",
     *         "Returned when something else is not found"
     *       }
     *   }
     * )
     * POST Route annotation.
     * @Post("/playlists/new")
     */
    public function newPlaylistAction(Request $request)
    {
        $user = $this->get('security.context')->getToken()->getUser();

        $view = $this->get("app.algo")->generate_playlist($request->get('name'), $user, $request->get('soundcloud_user'), $request->get('nbr_music'));
        $view = $this->view($view, 200);

        return $this->handleView($view);
    }

}

redpajama_set_name: RedPajamaGithub


It's a good bet that if a race track across the country put out a call to the folks at Central Casting in Hollywood asking for handicapper and racing analyst they would send you one Frank Carulli.
For the last decade folks in Maryland have been lucky to call that same Frank Carulli their own as he has been the quintessential racing odds maker for Laurel Park and Pimlico Race Course. For 11 years it has been his Preakness Morning Line that the betting world has waited for with baited on that third Wednesday in May ahead of the second jewel of racing's Triple Crown right here in Baltimore.
That said, Las Vegas has come a calling and the Frank Carulli farewell tour around these parts has begun.
Something tells me while Maryland is the best place in the business to be a racing handicapper and racing analyst, Las Vegas is the ultimate destination for a professional gambler like Frank Carulli.
But always, as one door closes another one opens. Or like they may say at the track, when one gate closes another opens! Just ask the likes of Ryan Fogelsonger, Dylan Smith, Jackie Savoye and Gabby Gaudet.
This week (March 20-23) at Laurel Park, the Maryland Jockey Club will have those four young horsemen and woman as guest handicappers competing for Carulli's on-air role as the Pimlico and Laurel television host.
Here's your Racing Form of sorts to handicap the entries. All thanks to Mike Gathagan from the Maryland Jockey Club.
Fogelsonger, 31, won 1,303 races as a jockey and captured eight riding titles at the Maryland tracks. The 2002 Eclipse Award winning apprentice has not ridden since early November when he suffered a concussion during a spill. The same Ryan Fogelsonger (above) who this blogger saw ride Chick Lang's ashes around the historic oval at Old Hilltop one last time. The same Ryan Fogelsonger who also has been a great interview every time this railbird has come a calling.
Smith (second from the left alongside Jackie Savoye), 24, has worked for trainer Dickie Small since graduating from right down the road at Kennedy High School in Silver Spring in 2006. We're talking a real racing insider.
Savoye is currently an assistant trainer for Dale Capuano. The 25-year-old South River High School graduate did on-air work at Gulfstream Park and Monmouth Park two years ago. A ringer? Maybe!
Gaudet, the daughter of longtime conditioners Eddie and Linda Gaudet, is finishing up her final semester at Towson University, where she is studying mass communication and graphic design. Some pretty good training this blogger would say.
CLICK HERE to check out more of J. Lee Fleenor's Photostream that includes this great photo of Gabby!
And from the looks of things. The folks at Laurel Park and Pimlico have made a great break from the gate when it comes to finding a replacement for the jovial handicapper and racing analyst who is pulling-up stakes and heading to the dream home for any handicapper, Las Vegas.
Not to worry. Frank is leaving his morning line duties in good hands.
Equibase chart caller Keith Feustle (above left with Bill Brasaemle) , who co-hosts the "Today At The Races" pre-race show on the Maryland simulcast signal with track announcer Dave Rodman since the fall 2011, will take over Carulli's morning line duties beginning with the Laurel fall meet in September. Feustle has been the morning line maker at Colonial Downs since 2003.
CLICK HERE to hear and see my feature this past year on Keith Feustle and his Equibase partner Bill Brasaemle.
One of the greatest things about racing is the people who you see each and every day at the track.
People like Frank Carulli, Keith Feustle, Bill Brasaemle, Ryan Fogelsonger, Dylan Smith, Jackie Savoye, Gabby Gaudet, Dickie Small, Jim McCue, Jerry Dzierwinski, Georganne Hale, Coley Blind. Kevin Dzbynski, Butch Hawker, Dave Rodman, Mike Gathagan, Tom Chuckas, Chris Grove, King Leatherbury, Mike Trombetta, Mario Verge, Joe Miller, David Whitman, Carrie Everly, Phoebe Hayes and Phil Grove. The list goes on and on.
There are real characters around every corner at the track. Frank Carulli is one of those characters who has made the Maryland racing experience so enjoyable for so many people from so many walks of life for so many years.
While Laurel Park and Pimlico just won't be the same once Frank Carulli handicaps his last race on that last weekend of the Pimlico meet in late May, Maryland racing is better for having had Frank Carulli as its lovable handicapper for the past 11 years!
So in these last few weeks of the winter meet at Laurel and during the spring meet at Pimlico, make sure you make a point to give Frank Carulli a tip of your Racing Form!
It's a good bet you'll see him at the betting window.


text:
Mitsubishi Outlander PHEV range revised for 2020
The Mitsubishi Outlander PHEV, still the UK's most popular plug-in hybrid electric vehicle, has been revised for 2020 into a new six-model line-up.
Mitsubishi, Outlander
Mitsubishi Outlander PHEV Review
A few years ago, the national press and – it seemed – the national psyche, were preoccupied by an excess of Daily Mail-style hand-wringing about 4x4s being planet-killers and gas-guzzlers. I'd have loved to have had a Mitsubishi Outlander PHEV back then, because this is an SUV that would have blown their tiny minds. Why? Two numbers: 156 mpg and 42 g/km.
Mitsubishi Outlander PHEV Video Review
Watch our video review of the 2016 Mitsubishi Outlander PHEV.
Mitsubishi Outlander PHEV available now from £28,249
The new Mitsubishi Outlander PHEV (Plug-in Hybrid Electric Vehicle) is now available to order in the UK, with prices starting from £28,249 after a £5,000 Government grant.
New 2013 Mitsubishi Outlander now available, priced from £23,699
The new, third generation 2013 Mitsubishi Outlander is now available, powered by a revised version of the company's 2.2-litre diesel engine and in a choice of five grades, priced from £23,699
Mitsubishi Outlander PHEV plug-in hybrid SUV to debut at Paris
The new Mitsubishi Outlander PHEV plug-in hybrid SUV will be officially unveiled at the Paris show later this month
New Mitsubishi Outlander 2.0 DI-D SE and GSE
Mitsubishi is pleased to announce the arrival of two new variants to their versatile Outlander range; the Outlander 2.0 DI-D SE and GSE, priced from £19,999
August 3rd 2009
Mitsubishi Outlander to come with twin-clutch SST transmission
Mitsubishi in the UK has revealed that the all-new Outlander will now change gear seamlessly with the introduction of the Lancer Evolution X's Twin Clutch SST
Mitsubishi has released the first details of its new 2007 Outlander, due on sale in the UK from March 2007 priced from £19,449
Mitsubishi announces Outlander Concept
Mitsubishi will use the 2006 Paris Motor Show in September to launch its all-new European SUV, the Outlander, due to go on-sale spring 2007
July 3rd 2006


text:
Q: Facebook Wall Feed to Website - Jquery / not PHP I am trying to pull the activity from my Facebook Page Wall, including images to my website. However, with the standard Activity Plugin , shows everything (including my friends, but I only want to limit it to my pages posting).
Is there any way to do this in a Jquery way? Bar PHP.

A: You can use the JavaScript SDK to make an FQL Query(scroll down to the "API Calls" header) to the stream table. This will return a JSON object that you should be able to parse and display easily using jQuery.
Here is a sample query to get you started:
SELECT post_id, actor_id, target_id, message, attachment
  FROM stream
  WHERE source_id = 'PAGE_ID'
    AND actor_id = 'PAGE_ID'

The source_id in the WHERE statement above limits the results to just posts on your page's wall, and the actor_id limits the results to just those made by your page.

redpajama_set_name: RedPajamaStackExchange


This SketchUp training course is intended for students with basic SketchUp experience who want to investigate intermediate topics. This couse is suitable for those using SketchUp Pro and SketchUp Make.
In this advanced CSS training course you will learn high-end techniques for using Cascading Style Sheets to apply visual formatting to your HTML documents.


The warped and surreal nature of Paul Kaptein's sculptures are even more startling when you consider the medium: Kaptein hand-carves each piece from wood. And the "glitchy" aspect of the works is heightened by gaps and holes present throughout, in a sense emptying the figures of their worldliness. And with names like, "With the Poise of One Entering a Black Hole for the Third Time" (shown above), there's both a humor and cosmic quality to the Australian artist's work. Kaptein was last featured on HiFructose.com here.


text:
Gonomyia spicata är en tvåvingeart som beskrevs av Alexander 1921. Gonomyia spicata ingår i släktet Gonomyia och familjen småharkrankar.

Artens utbredningsområde är Peru. Inga underarter finns listade i Catalogue of Life.

Källor

Småharkrankar
spicata

redpajama_set_name: RedPajamaWikipedia


I've lost track, but I believe this will be my 7th year on the tour! For two days I open my studio for the public to see my work, talk about my processes and thinking, and share ideas. Every year I look forward to this event, while it gives me the impetus to wrap up projects and, oh yes, clean up the studio.
Take a look at this cool video the artists put together here.
Celebrating 25 years of opening our studios, over fifty artists and 4 art centers are participating this year! Visit art studios and see work in all its stages. Talk to artists about ideas, processes, and materials. Explore the places where art happens! FREE TO PUBLIC! Visit the site at whiterockartists.com to see who's doing what and where, and download a map to navigate your way through the neighborhoods! October 14 & 15, 10am to 5pm both days. Get your tourista shoes on and come visit!


How has the current state of the ICT sector translated into business opportunities for GBM?
The sector has been developing over the last few years. With the completion of extensive ICT infrastructure across the Sultanate, customers are now beginning to recognize how technology can help address crucial business concerns and contribute to their bottom line. Technologies such as big data, IT security, and data management centers can work to improve business processes across all industries and sectors.
Is ICT infrastructure in Oman complete, or is there room for development?
We are already at an advanced level in terms of infrastructure and development, though there is always room for evolution and development when it comes to technology. Gaps in the market do exist, and there is a need for increased awareness amongst major stakeholders about locating these in order to push market demand. In the current economic situation, decision makers are less willing to make investments in ICT. As it stands, there is also a need to enhance public and private sector partnerships to improve sectoral services.


text:
La Secretaria d'Estat de Cooperació Internacional és una Secretaria d'Estat de l'actual Ministeri d'Afers Exteriors, Unió Europea i Cooperació d'Espanya encarregada de la formulació, adreça, execució, seguiment i avaluació de la política exterior per a la cooperació internacional per al desenvolupament sostenible i de la coordinació de l'acció cultural exterior.

L'actual Secretaria d'Estat de Cooperació Internacional és, des del 20 de juliol de 2021, Pilar Cancela Rodríguez.

Funcions fins al 2020
Les funcions d'aquesta nova Secretaria d'Estat es regulen en el Reial decret 768/2017, en la Llei 40/2015 i mitjançant la Llei 23/1998, i són:

 Les competències reconegudes en l'article 62 de la Llei 40/2015.
 La proposta, adreça, coordinació i execució de la política de cooperació per al desenvolupament.
 L'administració dels recursos de cooperació gestionats pel Ministeri d'Afers Exteriors i de Cooperació.
 L'assegurament de la participació espanyola en les organitzacions internacionals d'ajuda al desenvolupament i la definició de la posició d'Espanya en la formulació de la política de desenvolupament de la Unió Europea.
 L'avaluació de la política de cooperació per al desenvolupament i de les operacions finançades amb fons públics, i la rendició de comptes de les activitats i resultats de la cooperació espanyola a les Corts Generals i a la societat espanyola.
 La preparació i coordinació de les Cimeres Iberoamericanes i la planificació i impuls de les activitats de la Comunitat Iberoamericana de Nacions; la col·laboració i suport a les funcions de la Secretaria General Iberoamericana; i el foment i la coordinació de la presència d'Espanya a l'Organització d'Estats Americans (OEA) i en els diferents organismes i entitats multilaterals d'àmbit iberoamericà, sense perjudici de les competències d'altres Departaments.

Funcions a partir del 2020
Al mes de gener es fa efectiva una renovació i la Direcció general per a Iberoamèrica i el Carib passà sota el control de la Secretaria d'Estat d'Afers Exteriors. I el 2021 es nombrà pròpiament un Secretari d'Estat per a Iberoamèrica i el Carib i l'Espanyol al Món.

Estructura
La Secretaria d'Estat d'Assumptes Europeus s'organitza en els següents òrgans:
 Direcció general de Polítiques de Desenvolupament Sostenible.
 Gabinet de la Secretaria d'Estat.
 L'Advocacia de l'Estat davant del Tribunal de Justícia de la Unió Europea.

Organismes adscrits
 Agència Espanyola de Cooperació Internacional per al Desenvolupament
 Institut Cervantes
 Acadèmia d'Espanya a Roma

Llista de secretaris d'Estat
 Luis Yáñez-Barnuevo García (1985-1991).
 Inocencio Arias Llamas (1991-1993).
 José Luis Dicenta Ballester (1993-1995).
 Miguel Ángel Carriedo Mompín (1995-1996).
 Fernando María Villalonga Campos (1996-2000).
 Miguel Ángel Cortés Martín (2000-2004).
 Leire Pajín Iraola (Cooperació internacional, 2004-2008)
 Trinidad Jiménez García-Herrera (per Iberoamèrica, 2006-2009).
 Soraya Rodríguez (cooperació internacional, 2008-2011).
 Juan Pablo de Laiglesia y González de Peredo (2009-2010).
 Juan Antonio Yáñez-Barnuevo García (2010-2011)
 Jesús Manuel Gracia Aldaz (2012-2016)
 Fernando García Casas (2016-2018)
 Juan Pablo de Laiglesia y González de Peredo (2018-2021)
 Pilar Cancela Rodríguez (2021-actualitat)

Referències

Enllaços externs
 Secretaria d'Estat d'Afers Exteriors

Ministeri d'Afers Exteriors d'Espanya
Secretaries d'Estat d'Espanya


Avon Big Color Eye Pencil	Mauve Elegance – .056 oz / 1.6g (2 Pack) - 56 oz lot of 2 pieces made in usa fresh stock, same day fast & free shipping. Avon big eye color pencil mauve elegance 0.
Youngblood Intense Eye Color Pencil, Black 1.1 g by Youngblood - 1 grams. These cosmetics are authentic and at an affordable priceprovides brilliant, long lasting color100% authenticprovides long lasting color1.
Youngblood Intense Eye Color Pencil, Chestnut, 1.1 Gram by Youngblood - These cosmetics are authentic and at an affordable priceprovides brilliant, long lasting color100% authentic.
L.A. Colors Jumbo Eye Pencil Shadow Liner 408 Sun Kissed by L.A. Colors - An eye liner that also use as an eye shadow. Bolder darker lines and blend for softer colorsjumbo eye color pencil.
Youngblood Intense Eye Color Pencil, Suede, 1.1 Gram - 100% authentic. Provides brilliant, long lasting color. These cosmetics are authentic and at an affordable price. Formulated with fabulous pigment provides pure bold color to define your eyes soft enough for smudging and blending easy to glide on and long lasting.
Youngblood Intense Eye Color Pencil, Passion, 1.1 Gram by Youngblood - These cosmetics are authentic and at an affordable priceprovides brilliant, long lasting color100% authentic.
Youngblood Youngblood Intense Eye Color Pencil, Black, 1.1 Gram - These cosmetics are authentic and at an affordable price, provides brilliant, long lasting color, 100% authentic.
Dodo Eye Color Pencil Water Proof – Yellow - Dual end eye color pencil (the vision of beauty haute street collection vol02), #cool x chic. Shu uemura.
Dodo Eye Color Pencil Water Proof – Green - Shu uemura. Dual end eye color pencil (the vision of beauty haute street collection vol02), #cool x chic.
Shu Uemura Haute Street Eye Color Pencil 3.3g-Cool x Chic - Or use as an eye shadow base to increase color payoff with other eye shadows. Go one step further and draw bold graphic lines for an electrifying haute street beauty look. Can be used as eye liners or blended out as eye shadows. Limited edition dual-ended eye color pencil in vivid blue and green paint shades to create a downtown edgy look. The eye color pencil can be used as a liner to create subtle gradation around the eyes. To be used with an underbase or eye shadow to prime the eye.
L.A. Colors Jumbo Eye Pencil Shadow Liner 413 Relaxation by L.A. Colors - Bolder darker lines and blend for softer colorsjumbo eye color pencil. An eye liner that also use as an eye shadow.
L.A. Colors Jumbo Eye Pencil Shadow Liner 402 Saltwater by L.A. Colors - An eye liner that also use as an eye shadow. Bolder darker lines and blend for softer colorsjumbo eye color pencil.
Youngblood Intense Eye Color Pencil, Chestnut 1.1 g by Youngblood - 1 grams. These cosmetics are authentic and at an affordable priceprovides brilliant, long lasting color100% authenticprovides long lasting color1.
Dodo Eye Color Pencil Water Proof – Orange - Dual end eye color pencil (the vision of beauty haute street collection vol02), #cool x chic. Shu uemura.


text:
//
//  JYCarousel.h
//  JYCarousel
//
//  Created by Dely on 16/11/14.
//  Copyright © 2016年 Dely. All rights reserved.
//

/*
 * 这是一个使用起来非常简单的开源库,自带下载缓存,不会造成循环引用,不用考虑定时器不会销毁(我都已经帮你做好了)
 * 如果使用过程中有任何问题,可以联系我,我会第一时间回复你,然后尽我的努力把这个库维护的更好,更简单方便的使用。
 * 谢谢支持,如果喜欢,请给我个star。
 *
 * 作者:Delyer
 * 简书:http://www.jianshu.com/users/e95705fe04d9    (现在写博客的主要地方)
 * 个人博客:http://dely.vip
 * github:https://github.com/Delyer
 * 邮箱:jiayaoit@126.com
 * 微信:Delyer521
 */

#import <UIKit/UIKit.h>
#import "JYConfiguration.h"
#import "JYPageControl.h"
#import "JYTitleLabel.h"

@protocol JYCarouselDelegate <NSObject>

@optional
- (void)carouselViewClick:(NSInteger)index;

@end

@interface JYCarousel : UIView

#pragma mark - ==============初始化==============

/**
 block方式回调初始化

 @param frame       frame
 @param configBlock 轮播属性配置(可以为nil,为nil时采用默认的配置)
 @param clickBlock  点击回调

 @return carousel
 */
- (instancetype)initWithFrame:(CGRect)frame
                  configBlock:(CarouselConfigurationBlock)configBlock
                   clickBlock:(CarouselClickBlock)clickBlock;

/**
 delegate方式回调初始化

 @param frame       frame
 @param configBlock 轮播属性配置(可以为nil,为nil时采用默认的配置)
 @param target      delegate

 @return carousel
 */
- (instancetype)initWithFrame:(CGRect)frame
                  configBlock:(CarouselConfigurationBlock)configBlock
                       target:(id<JYCarouselDelegate>)target;

#pragma mark - ==============开始轮播==============

/*
 start Carousel
 imageArray(里面可以存放UIImage对象、NSString对象【本地图片名】、NSURL对象【远程图片的URL】)
 titleArray 标题
 */
- (void)startCarouselWithArray:(NSMutableArray *)imageArray;
- (void)startCarouselWithArray:(NSMutableArray *)imageArray titleArray:(NSMutableArray *)titleArray;

/*
 start Carousel With new Config(更新轮播配置,新的样式轮播)
 configBlock 轮播属性配置(可以为nil,为nil时采用之前默认的配置)
 titleArray 标题
 */
- (void)startCarouselWithNewConfig:(CarouselConfigurationBlock)configBlock array:(NSMutableArray *)imageArray;
- (void)startCarouselWithNewConfig:(CarouselConfigurationBlock)configBlock array:(NSMutableArray *)imageArray titleArray:(NSMutableArray *)titleArray;

@end


text:
Covid Nightingale Courts: Winchester facility set up to help backlog will close this month
The site was one of several temporary courts set up at the start of the pandemic
Rachel Mather
Winchester Guildhall was set up as a Nightingale Court to cope with the backlog of cases that built up since 2020 (Image: HampshireLive - Grahame Larter)
Almost half of the temporary Nightingale Courts set up to cope with the backlog of legal cases that emerged during the Covid-19 pandemic are set to close.
This includes the three civil family and/or tribunal court rooms set up at the Guildhall in Winchester, which will be closed by the end of March 2022.
The court is one of eleven centres due to close, but the Ministry of Justice (MoJ) has confirmed another 12 in England and Wales will stay open until March 2023.
READ MORE: Prince Charles in Winchester: Where can you see the heir during rescheduled Hampshire visit
Nightingale Courts opened in at the start of the coronavirus pandemic because additional space was needed to ensure social distancing rules were abided between those attending court.
However, the latest figures show that in December 2021 the crown court backlog fell by over 2,000, dropping to under 59,000.
Meanwhile, in the magistrates' courts, the outstanding criminal caseload has dropped by almost 70,000 cases since its peak in July 2021.
Justice Minister, James Cartlidge, said: "Nightingale Courts continue to be a valuable weapon in the fight against the pandemic's unprecedented impact on our courts providing temporary extra capacity.
HampshireLive newsletter: We bring the stories to you
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"Combined with other measures – such as removing the cap on Crown Court sitting days, more use of remote hearings, and increasing magistrate sentencing powers – we are beginning to see the backlog drop so victims can get the speedier justice they deserve."
The MoJ says the sites that are closing are no longer needed because social distancing measures have eased and there are sufficient rooms for all the available Crown Court judges.
However, to further tackle the backlog of cases from the past two years it has also been announced that 1,100 new judges will be hired.
Courts that will remain open until next year are located in London, Maidstone, Chichester, Telford, Wolverhampton, Birmingham, Leeds, Swansea, Cirencester and Fleetwood.
Find out how you can get more HampshireLive news straight to your inbox HERE .
Hampshire weather: Weekend forecast for Portsmouth, Southampton and Winchester after UK hit by 'wintry blast'
Southampton crime stats: City has Hampshire's highest crime numbers with sharp increase in violent offences
Isle of WightElderly Isle of Wight pedestrians seriously injured after being hit by van The man and woman in their 80s were taken to hospital after the collision in Church Litten, Newport
Teenage girl seriously injured in police-led incident on Hampshire M27
An air ambulance was sent to the incident between Fareham and Portsmouth
Motorcyclist, 34, dies after late-night A31 accident near Winchester
The crash victim was sadly pronounced dead at the scene
Mum, 40, who was being sick all day went to bed early and died in her sleep
Kelly Gleeson thought she was suffering from food poisoning
Southampton FCSouthampton transfer latest as manager Nathan Jones makes Che Adams point amid Everton interestSouthampton manager Nathan Jones spoke to the media on Monday morning to preview his side's trip to Newcastle for the EFL Cup semi-final second leg at St James' Park
Tottenham make January transfer decision over Dane Scarlett's future amid Portsmouth loan
Tottenham loanee Dane Scarlett will spend the rest of the season with Portsmouth after the Premier League outfit decided to not recall the striker in the January transfer window
Hampshire amputee going for gold after joining table-tennis elite players
Simon Heaps, from Milford on Sea has raised over £60,000 in an bid to compete across the world


text:
Even the smallest stroke can damage brain tissue and impair cognitive function
Blocking a single tiny blood vessel in the brain can harm neural tissue and even alter behavior, a new study from the University of California, San Diego has shown. But these consequences can be mitigated by a drug already in use, suggesting treatment that could slow the progress of dementia associated with cumulative damage to miniscule blood vessels that feed brain cells. The team reports their results in the December 16 advance online edition of Nature Neuroscience.
"The brain is incredibly dense with vasculature. It was surprising that blocking one small vessel could have a discernable impact on the behavior of a rat," said Andy Y. Shih, lead author of the paper who completed this work as a postdoctoral fellow in physics at UC San Diego. Shih is now an assistant professor at the Medical University of South Carolina.
Working with rats, Shih and colleagues used laser light to clot blood at precise points within small blood vessels that dive from the surface of the brain to penetrate neural tissue. When they looked at the brains up to a week later, they saw tiny holes reminiscent of the widespread damage often seen when the brains of patients with dementia are examined as a part of an autopsy.
These micro-lesions are too small to be detected with conventional MRI scans, which have a resolution of about a millimeter. Nearly two dozen of these small vessels enter the brain from a square millimeter area of the surface of the brain.
"It's controversial whether that sort of damage has consequences, although the tide of evidence has been growing as human diagnostics improve," said David Kleinfeld, professor of physics and neurobiology, who leads the research group.
To see whether such minute damage could change behavior, the scientists trained thirsty rats to leap from one platform to another in the dark to get water.
The rats readily jump if they can reach the second platform with a paw or their snout, or stretch farther to touch it with their whiskers. Many rats can be trained to rely on a single whisker if the others are clipped, but if they can't feel the far platform, they won't budge.
"The whiskers line up in rows and each one is linked to a specific spot in the brain," Shih said. "By training them to use just one whisker, we were able to distill a behavior down to a very small part of the brain."
When Shih blocked single microvessels feeding a column of brain cells that respond to signals from the remaining whisker, the rats still crossed to the far platform when the gap was small. But when it widened beyond the reach of their snouts, they quit.
The FDA-approved drug memantine, prescribed to slow one aspect of memory decline associated with Alzheimer's disease, ameliorated these effects. Rats that received the drug jumped whisker-wide gaps, and their brains showed fewer signs of damage.
"This data shows us, for the first time, that even a tiny stroke can lead to disability," said Patrick D. Lyden, a co-author of the study and chair of the department of neurology at Cedars-Sinai Medical Center in Los Angeles. "I am afraid that tiny strokes in our patients contribute--over the long term--to illness such as dementia and Alzheimer's disease," he said, adding that "better tools will be required to tell whether human patients suffer memory effects from the smallest strokes."
"We used powerful tools from biological physics, many developed in Kleinfeld's laboratory at UC San Diego, to link stroke to dementia on the unprecedented small scale of single vessels and cells," Shih said. "At my new position at MUSC, I plan to work on ways to improve the detection of micro-lesions in human patients with MRI. This way clinicians may be able to diagnose and treat dementia earlier." --Susan Brown
Additional authors include Pablo Blinder, Beth Friedman, Geoffrey Stanley and Philbert S. Tsai, all at UC San Diego. The National Institutes of Biomedical Imaging and Bioengineering, Mental Health, and Neurological Disease and Stroke provided primary funding through grants to Kleinfeld (EB003832, MH085499, and OD006831). Shih was further supported by a postdoctoral fellowship from the American Heart Association.
Related Dementia Articles from Brightsurf:
The danger of Z-drugs for dementia patients
Strong sleeping pills known as 'Z-drugs' are linked with an increased risk of falls, fractures and stroke among people with dementia, according to new research.
The long road to dementia
Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain.
Why people with dementia go missing
People with dementia are more likely to go missing in areas where road networks are dense, complicated and disordered - according to new research from the University of East Anglia.
Dementia education
School-based dementia education could deliver much needed empathy and understanding for older generations as new research from the University of South Australia shows it can significantly improve dementia knowledge and awareness among younger generations.
Building dementia friendly churches
A project to help church communities become more 'dementia friendly' has had a significant impact across the country.
A "feeling" for dementia?
A research team led by the DZNE concludes that personal perception can be an important indicator for the early detection of Alzheimer's disease.
New biomarker for dementia diagnosis
Medical researchers in the UK and Australia have identified a new marker which could support the search for novel preventative and therapeutic treatments for dementia.
Digital solutions for dementia care
Telehealth delivery of dementia care in the home can be as effective as face-to-face home visit services if carers and recipients take advantage of the technologies available, Australian researchers say.
Despite a marked reduction in the prevalence of dementia, the number of people with dementia is set to double by 2050 according to new Alzheimer Europe report
Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe.
Read More: Dementia News and Dementia Current Events


A lengthy casino cash dispute between the Seneca Nation of Indians and New York state could pose some problems for the city's finances.
City Comptroller Maria Brown said Tuesday the decision by Seneca tribal leaders to suspend casino cash payments to the state is not cause for immediate concern, but could present at least one serious challenge if the two sides remain at odds months from now.
Brown said the city's 2010 budget relies on 2009 casino cash revenues to cover a debt service increase of roughly $4.5 million. Brown said the city was still awaiting payment for its share of the 2009 casino revenue when Seneca leaders agreed on Monday to withhold future allocations because they felt state-approved gambling operations threatened their Western New York casino operations. Brown said the city has enough cash reserves to cover its debt service obligations through the end of the year, but would not have sufficient funds to do the same in 2011.


Unleash true productivity from Canon imagePROGRAF iPF765 with PlotWorks Pro batch print workflow software.
Designed for exceptional results in all CAD/GIS environments, the imagePROGRAF iPF765 is a 36"/A0 printer that delivers quality results and a fast return on investment.
The Canon iPF765 a powerful print solution designed to meet the demands of medium to large workgroups. With incredible line accuracy, a 250GB hard drive, and support for HP-GL/2 and HP-RTL files, it is an ideal solution for any professional with a need for printing complex renderings, CAD drawings, GIS maps and other large-format graphics.
A slim design and full front operation means you can install the printer anywhere – even flush against a wall to save valuable office space.
High productivityProductivity is maintained in networked environments thanks to the Media Mismatch function. When a job is sent to print with a different media to that which is loaded, the user is informed and given the option to cancel it, print it anyway or change the media. In the meantime, the iPF765 prints other jobs in the queue.
Economical and efficientA built in accounting function allows tracking of the cost per print enabling you to view the data through the printer driver. Economy mode can be selected which uses less ink ideal when printing draft documents. Canon's eMaintenance software automatically detects and manages mechanical problems and low ink levels linking directly to Canon service.
Exceptional quality & accuracyCanon's 5-colour dye-and-pigment ink system produces vivid colours and the sharpest, thinnest lines. With an accuracy of +/- 0.1% and a minimum line width of 0.02mm, precision is guaranteed. Images are rendered at 2,400 x 1200 dpi for maximum impact from super-fine print heads using 15,360 nozzles.
Built for demanding workflowsThe iPF765 is HP-GL/2 and HP-RTL compatible, including palette and pen settings. As well as Optimised Driver for AutoCAD and for Microsoft Office users, there is a plug-in to print in Word, Excel and PowerPoint.