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Champions of an Evolving Curry Nation. And Guess What's Cooking at New Delhi Aerocity-Gurgaon.
Posted: April 2, 2016 at 5:22 pm / Chef Interviews
Third Homecoming of Britain's 'Curry Restaurants' Saw Celebrated Chef Dominic Chapman & Curry Life Editor Syed Bilal Ahmed at ITC Maurya. JUST LIKE his understated personality, and his ability not to advertise his family history or his many claims to fame, there's nothing flamboyant about Dominic Chapman's cooking. I met the soft-spoken, smiling Englishmen at […]
Sri Lankan Cuisine Meets Japanese Perfection at Self-Taught Master Chef Dharshan Munidasa's Kitchen
Posted: February 16, 2016 at 5:18 pm / Chef Interviews
FATE WORKS in mysterious ways. Had Sri Lankan super chef Dharshan Munidasa's father not died six months before he graduated from Johns Hopkins University with a double degree in Computer Engineering and International Relations in 1994, he would have taken up the corporate job that awaited him in Tokyo, his birthplace, and perhaps never opened […]
FOOD HALL OF FAME: Eight Chefs Who Have Defined All That's Good & New About Indian Cuisine
Posted: September 28, 2014 at 5:14 pm / Chef Interviews
THOSE of us who remember the Emergency days (1975-77), may find it hard to forget the slogan that every bus had to mandatorily carry: 'India is on the move'. Today, the slogan can be re-written to state a universally acknowledged fact: 'Indian cuisine is on the move'. We owe it to three generations of chefs, […]
Sitting in Delhi, Eating in Madurai and Talking Khushboo Idlis with Dakshin's Custodian, Praveen Anand
Posted: July 5, 2014 at 5:10 pm / Chef Interviews
FEW INDIANS have worked as hard as Praveen Anand, Brand Custodian of ITC's Dakshin restaurants (six, and counting!) and Executive Chef, Sheraton Park Hotel & Towers, Chennai, to document our country's rich culinary heritage and gastronomical traditions. In the last 25 years that he has spent giving birth to and mothering Dakshin restaurants across the […]
Kwality's Corporate Chef Sultan Mohideen Eyes Guinness World Records with 72-Kilo Paneer TikkaIT IS chicken tikka masala (CTM) that's been making history. Back in 2001, the then UK foreign secretary Robin Cook declared it to be "a true British nation
Posted: April 13, 2014 at 1:09 pm / Chef Interviews
IT IS chicken tikka masala (CTM) that's been making history. Back in 2001, the then UK foreign secretary Robin Cook declared it to be "a true British national dish". More recently, in 2009, Pakistani-born British MP Mohammad Sarwar tabled a motion in the House of Commons seeking protected geographical status for Glasgow's CTM. Now, it's […]
THE GOOD CHEF: Custodian of Delhi's Dakshin is an Encyclopedia of Southern Gastronomy
Posted: March 3, 2014 at 5:01 pm / Chef Interviews
I HAVE been having food cooked by Velumurugan Paul Raj at my favourite Dakshin for many years, so when Anchal Ghosh, the EDM-loving PR of the Sheraton New Delhi, extended me an invitation to sample the Mudaliar spread laid out by the restaurant last week, I jumped at the opportunity because it meant meeting the […]
As He Re-Engineers The Wine Company's Menu, Chef Saby Shares Fabrica's Business Plans
Posted: January 19, 2014 at 4:57 pm / Chef Interviews
I WAS trying to shake off the dreariness of Delhi's weather the other day at my favourite Soda Bottle Openerwala (SBOW) at the DLF Cyber Hub in Gurgaon, when I ran into Megha Kohli, a young chef with the happiest face in the business. I had heard Megha had joined Fabrica, the new company floated […]
Taj's Grand Master, Hemant Oberoi, Unveils his First Book and a Tempting New Menu at Masala Art
Posted: December 12, 2013 at 4:53 pm / Chef Interviews
ONE OF the biggest mistakes The Oberoi group made was not to hire Hemant Oberoi. He was asked to tweak his surname because there could be only one Oberoi in the group. The young man destined to become the country's most accomplished chef of his generation refused to relent. Instead, he joined the Taj, and […]


At a recent new business presentation, our team from SMZ introduced themselves and talked about being "extra eyes" for the client prospect. We're proud to say we did win that business, hence the eyes have it.
That led me to think about all the ways we as a good (to great) agency use our extra eyes.
We study the competition. Not just their spend and media mix but how they present the brand and deliver the customer experience.
We look at consumer trends. Each year we report on the Pantone color of the year. "Intense colors seem to be a natural application of our intense lifestyles and thought processes these days," Pantone Color Institute executive director Leatrice Eiseman forecasts for 2018. If you're a fan of tennis and watched the U.S. Open and the players' clothing, you know that to be true.
We board the bus and get out in the field. SMZers recently did a tour of Detroit with Detroit Experience Factory, got a behind-the-scenes look at the new Little Caesars Arena (Red Wings home opener tonight!) and shopped fitness centers. Sometimes a workout is work.
If we do some if not all of these extra eyes activities, we help make brands stronger and brand leaders a little smarter. May I call the vote? The eyes have it.


Reps. Frank A. LoBiondo and Ted Poe both said Tuesday they will retire but had seemingly different reasons.
Democrats need roughly two dozen more seats to win back the U.S. House in 2018. And some say the wave of Republicans leaving only helps their chances.
As of Tuesday, two more House Republicans said they'll retire, meaning by now, at least 25 GOP incumbents won't be running next year.
But Reps. Frank A. LoBiondo and Ted Poe seem to be retiring for different reasons.
Poe said he wanted to spend more time with his family. LoBiondo, on the other hand, gave a fierce critique of Congress.
LoBiondo's frustration with a divisive and uncompromising government falls in line with what fellow Republicans Jeff Flake and Charlie Dent said when they announced they were leaving Congress.
Moderate Republicans becoming frustrated and leaving could be good news for Democrats because a number of those more centrist representatives — including LoBiondo — come from competitive districts.
But the bad news for the left is the majority of Republicans who've said they're not coming back are from red-leaning states. And with several moderates leaving, the House could be both Republican-led and more polarized come 2019.


The current debate about food stamps is fantastic—unless you are someone who likes facts and evidence.
To follow the congressional debate about food stamp (SNAP) funding in the Farm Bill—and media coverage of that debate—you would think that the relevant issues are the deficit, rapists on food stamps, waste and abuse and defining our biblical obligation to the poor.
The only thing missing from that conversation is the state of hunger in America today and how we should respond to it.
"A good part of the food stamp debate in Congress and the media is not an evidence-based conversation, it's fantasy-based," says Jim Weill, president of the Food Research and Action Center (FRAC), a nonprofit organization working to improve public policies to eradicate hunger in the United States.
Weill insists that there is plenty that we know about food stamps that Congress and the media are busy ignoring, including from the government's own data: a January 2013 Institute of Medicine (IOM)/National Research Council (NRC) report clearly described the inadequacy of SNAP benefits for most people struggling with hunger.
"The whole thrust of the report is that this is not a benefit allotment that's adequate for people in most real world circumstances," says Weill.
Since the average benefit for a SNAP recipient is just $4.50 per day, this conclusion shouldn't come as much of a shock. But the authors—who comprised a blue-ribbon panel charged with conducting a scientific analysis of benefit levels—did a good job breaking down exactly why the benefit allotment might come up so short.
There is also a bizarre assumption in the SNAP program that food prices are consistent across the nation—from Snohomish County, Washington, to Neodesha, Kansas, to New York City. Benefits are adjusted only for Hawaii and Alaska.
Any one of these factors would be sufficient reason to revise upward the amount of assistance offered to hungry families, but there is more.
Even the way a family's monthly net income is calculated is flawed. For families with earnings, Social Security or other income, there is a shelter deduction capped at $469 (unless there is an elderly or disabled member of the household). The report notes "considerable evidence that [SNAP] households face housing costs in excess of the current cap on the shelter deduction, which results in overestimation of the net income participants have available to purchase food." Translated, SNAP families are paying more for housing—and have less income available for food—than the government is assuming; the SNAP benefit is lower for many families than it should be due to flawed assumptions about their net income.
In calculating net income there are also no deductions permitted for out-of-pocket medical costs for nonelderly, nondisabled SNAP participants.
Weill sees a willful ignorance at play "in some corners of Congress" when it comes to examining current benefit levels.
"It's possible that the inadequacy of SNAP benefits might have better come to Congress' attention if the House of Representatives—among its numerous hearings on the Farm Bill—had held a single hearing on the food stamp program, which it didn't," he says.
Also, for all of the GOP's talk about designing welfare programs that move people towards self-sufficiency, it is completely ignoring (as are too many Democrats) new research showing that SNAP does exactly that.
And yet here we are, teetering on the edge of cutting $21 billion from a SNAP program that is assisting one in seven Americans; it's a cut that would remove 2 million people from the program and cause more than 200,000 low-income children to lose access to school meals. Even the Democratic-led Senate is proposing a $4 billion cut, which the Congressional Budget Office estimates will result in 500,000 households losing $90 per month in SNAP benefits.
You can let Congress know that current proposals to cut the SNAP program ignore all of the evidence—that we need to protect and strengthen the program. Participate in today's National Call-In Day to Protect SNAP.
Workers at Guitar Center's Manhattan location are unionizing. Read Allison Kilkenny's report here.


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Los fibromas de mama Cleansing and Super Cleansing -Super Limpieza
Uterine Leiomyomata in Relation to Insulin-Like Growth Factor-I, Insulin, and Diabetes fibr
Department of Radiology, George Washington University Medical Center, George Washington University, Washington, DC 20037
Short-term, within-person variability in clinical chemistry test results. Experience from the Atherosclerosis Risk in Communities Study.
[Cancer Epidemiol Biomarkers Prev. 2005]
There was an inverse association between diabetes and fibroids, especially for blacks (), where the estimated reduction in prevalence was -14% (0% to -29%). Black women who reported gestational diabetes but no other diagnosis of diabetes also tended to be less likely to have fibroids, but the confidence interval was broad (). All diabetes was adult onset with the exception of two black women who reported diagnoses at ages 13 and 16. Of those diagnosed with diabetes, 81% reported taking medication. Among blacks (the ethnic group with more diabetics) the inverse association between diabetes and fibroids was very similar for the 13 women who had been diagnosed at least 5 years prior to study enrollment compared with the 32 women who had more recent diagnoses (adjusted ORs = 0.47 and 0.52, respectively).
Our assessments of IGF-I, BP3, and insulin were based on measurements from a single blood sample. However, these ctors track over time for individuals,
For BP3, there was no evidence of an association with fibroids in any of the analyses. The molar ratio of IGF-I to BP3 was also examined, but it was highly correlated with IGF-I (r = 0.84 and 0.85 for blacks and whites, respectively) and showed similar, although slightly weaker, associations to those seen for IGF-I.
eSupplemental materialfor this article is available with the online version of the journal at click on &x0201c;Article Plus.&x0201d;
Growth advantage of human leiomyoma cells compared to normal smooth-muscle cells due to enhanced sensitivity toward insulin-like growth ctor I.
Insulin-like growth ctor-I and insulin are associated with the presence and advancement of adenomatous polyps.
Immunohistochemical localization of growth ctors and their receptors in uterine leiomyomas and matched myometrium.
Using logistic regression, we estimated the age-adjusted odds of fibroids and then the fully-adjusted odds of fibroids for tertiles of IGF-I, BP3, and insulin. The relation between diabetes and fibroids was also examined with age-adjusted and fully-adjusted logistic models. Sensitivity analyses were conducted to assess the impact of minor variations in our diagnostic definition of fibroids. For IGF-I, BP3, and insulin we also conducted logistic analyses based on size of the largest fibroid as the outcome (this analysis could not be done for diabetes because of the small numbers of diabetic women). The fibroid diameter, as a continuous variable, was not normally distributed, and various transformations did not produce normality. Therefore, we categorized the largest tumor diameter (small; &x0003c;2cm; medium; &x0003e;2 to &x0003c;4 cm; or large; &x02265;4 cm), and compared each category as a separate outcome with women without fibroids (LOGISTIC procedure in SAS, SAS Institute, Cary, NC). Because fibroids are common, prevalence differences for the important associations from the logistic analyses were estimated with binomial regression
Insulin-like growth ctors, insulin-like growth ctor-binding proteins, and endometrial cancer in postmenopausal women: results from a U.S. case-control study.
Both estrogen and progesterone may stimulate their development. Although the mechanisms by which these hormones influence tumor onset and progression is not well understood (reviewed in Schwartz and Marshall
IGF-I showed no association with fibroids in blacks, but in whites the adjusted odds ratios (aORs) for both mid and upper tertiles compared with the lowest tertile were 0.6 (95% confidence intervals [CI] = 0.3&x02013;1.0 and 0.4&x02013;1.1, respectively). Insulin and diabetes both tended to be inversely associated with fibroids in blacks. The insulin association was with large fibroids; aOR for the upper insulin tertile relative to the lowest was 0.4 (0.2&x02013;0.9). The aOR for diabetes was 0.5 (0.2&x02013;1.0). Associations of insulin and diabetes with fibroids were weak for whites. BP3 showed no association with fibroids.
The Bayesian analysis provided a method for evaluating effects on tumor onset compared with tumor progression, thus allowing us to begin to estimate associations with incidence in this cross-sectional study. We used a multistate modeling approach
Specific fiber deficits in sensorimotor diabetic polyneuropathy correspond to cytotoxicity against neuroblastoma cells of sera from patients with diabetes.
and single measures have been predictive of disease incidence after several years of followup. The primary limitation of this study is the cross-sectional nature of data collection. IGF-I and insulin levels were measured in blood samples taken at the same clinic visit as the ultrasound screening for fibroids. A large percentage of fibroid cases were newly detected at screening (42% of black cases and 68% of white cases). Still, some fibroids were already large, and time of initial development is unknown because fibroids can remain asymptomatic for years. However, it seems unlikely that fibroids determine circulating IGF-I levels or prevent diabetes, so reverse causation is probably not an issue. Although numbers were limiting, we examined time-since-diabetes diagnosis within our black sample and found that the diabetes-related inverse association did not appear to vary by time-since-diagnosis, again suggesting that reverse causation is unlikely.
Circulating IGF-I comes primarily from the liver. It may be that ctors such as t metabolism that affect liver IGF-I transcription and secretion (thus determining circulating levels) have little influence on tissue levels in the uterus where transcription can occur in situ under the influence of estrogen.
Contrary to our hypothesis, high circulating IGF-I and insulin were not related to increased fibroid prevalence. Instead, there was suggestion of the opposite. The inverse association with diabetes, although based on small numbers, is consistent with previously reported findings. Future studies might investigate vascular dysfunction as a mediator between hyperinsulinemia or diabetes and possible reduced risk of fibroids.
found no association with diagnosed diabetes (OR = 0.9; CI = 0.4&x02013;2.2), but an increased relative odds of 2.0; (0.4&x02013;12.6) for the women taking medication for diabetes. Consistent with our findings, Wise et al
Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
The extent to which circulating IGF-I may contribute to tumorigenesis is unknown. Most of the circulating IGF-I is produced in the liver. Higher levels have been associated with increased risk of breast cancer, another hormonally mediated tumor (reviewed by Renehan et al,
Clinical Pathology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
Insulin-like growth ctor-binding proteins in serum and other biological fluids: regulation and functions.
). Two studies have examined circulating levels of IGF-I in which women with and without uterine fibroids were compared. Neither showed differential levels, although sample sizes were small (cases and controls combined were 81 in 1 and 40 in the other).
Weight was measured at the clinic visit, and other data werUterine Leiomyomata in Relation to Insulin-Like Growth Factor-I, Insulin, and Diabetes fibre collected during a telephone interview conducted by trained interviewers or from responses to a self-administered questionnaire. Diabetics were those responding &x0201c;yes&x0201d; to the question on the self-administered questionnaire &x0201c;Has a doctor or health professional ever told you that you had diabetes, high blood sugar or &x0201c;sugar,&x0201d; not pregnancy induced?&x0201d; Gestational diabetes was ascertained with the reproductive history questions in the telephone interview. For each delivery the participant was asked &x0201c;Did you have any special medical problems during the pregnancy including (a list of 8 complications, 1 of which was) gestational diabetes (diabetes beginning during pregnancy)?&x0201d;
In summary, we found no evidence for increased risk of fibroids with high circulating IGF-I or insulin levels. In ct, both ctors showed tendencies for protective associations.
[Gastroenterology. 2005]
the endocrine effects of circulating levels may be more important for breast cancer than for fibroids. The inverse association between circulating IGF-I levels and fibroid development in whites was surprising, but the reported associations between IGF-I and endometrial cancer are also generally inverse (reviewed in Lacey et al
Address correspondence to: Donna Baird, Epidemiology Branch, A3-05, 111 TW Alexander Dr., Bldg 101, Rm 308, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, Telephone: (919) 541-2786, FAX: (919) 541-2511,
To evaluate the robustness of our results, we repeated the logistic analyses with minor changes in our definition of fibroids. First, we reassigned women who had no fibroids at ultrasound and no prior surgery for fibroids but had been previously told by a doctor that they had fibroids (32 blacks and 17 whites). They were moved from the &x0201c;no fibroid&x0201d; to the &x0201c;fibroid&x0201d; group. Second, we excluded women who had no focal fibroids but whose sonogram showed diffuse heterogeneity (75 blacks and 39 whites). These reanalyses showed results that were similar to those based on the original categorization of fibroid diagnosis. We also examined potential effect modification by BMI and exercise on the associations between insulin and IGF-I with presence of any sized fibroid. In none of these analyses was the interaction term important (p &x0003e; 0.10).
found a reduced risk of fibroids among diabetics in the Black Womens Health Study (0.77; 0.60&x02013;0.98).
Serum C-peptide, insulin-like growth ctor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women.
Estrogen-induced changes in IGF-I, Myb mily and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines.
with a flexible stochastic model that incorporates data on age at any prior diagnosis, age at study ultrasound, and size of largest fibroid (if any were found) to characterize onset and subsequent progression of fibroids. Fibroid onset is defined as the time at which the tumors first grow large enough to be detectable by a sonogram. Even though a large percentage of participants with fibroids had never had a clinical diagnosis of fibroids, the true onset time is unknown. During a preclinical phase and even after clinical diagnosis, fibroids may continue to grow. Our Bayesian approach utilizes survival analysis techniques to integrate data on first diagnosis of fibroids (for those who had been diagnosed before study enrollment) and size of the largest fibroid. The analysis is implemented using a Markov chain Monte Carlo algorithm, after choosing noninformative prior distributions. Hypothesis tests of ordered trends in tumor onset and progression across categories of the variables of interest are based on estimated posterior probabilities. Posterior probabilities 0.95 or more are considered important.
To our knowledge, no previous large epidemiologic study has examined the association between circulating IGF-I or insulin levels and fibroid development, although 2 studies have reported on associations with diabetes. Based on very small numbers Faerstein et al
We had hypothesized that hyperinsulinemia would increase fibroid risk because of its proliferative effects on uterine smooth muscle in culture. However, there are also biologic pathways whereby hyperinsulinemia and diabetes might plausibly decrease fibroid development. Vascular dysfunction is part of the pathogenesis of diabetes and could inhibit tumor development. Insulin resistance and diabetes can be associated with cytotoxic effects both from accompanying hyperglycemia and from other circulating cytotoxic ctors,
The NIEHS Uterine Fibroid Study was designed to estimate prevalence and age-specific cumulative incidence of uterine fibroids and to investigate risk ctors. Detailed methods have been described.
Clonal determination of uterine leiomyomas by analyzing differential inactivation of the X-chromosome-linked phosphoglycerokinase gene.
Given these findings as well as the data linking IGF-I with breast cancer, we hypothesized that increased circulating levels of IGF-I and insulin would be associated with increased fibroid development. However, we found either no association or inverse effects for fibroids in both age-adjusted and fully-adjusted models of circulating IGF-I and insulin. Reduced prevalence of fibroids was seen for white women with mid or upper tertile values of IGF-I, whereas there was no association for black women. Blacks with mid or upper tertile values of insulin had a reduced prevalence of large fibroids, and consistent with the insulin association, blacks with diabetes also had a reduced prevalence of fibroids. Circulating BP3 was not associated with fibroid development.
Briefly, the computerized membership records of a prepaid health plan in Washington, DC were used to select randomly 35&x02013;49-year-old women. Those selected were screened for eligibility by telephone. Eligibility criteria were 1) the computerized listing had correctly identified 35&x02013;49-year-old woman with current membership at the study site, and 2) a telephone interview could be conducted in English. A total of 1323 black and white women agreed to participate () (83% of those identified as eligible). Thfibromase research was approved by the NIEHS and George Washington University Human Subjects Review Boards, and participants gave informed consent. The analysis is limited to premenopausal participants who made a study clinic visit at which time a sting blood sample was drawn ().
Upregulation of IGF-I is also seen in fibroid tissue from the Eker rat, an animal model for fibroids.
Uterine Leiomyomata in Relation to Insulin-Like Growth Factor-I, Insulin, and Diabetes fibromas,Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
The associations of IGF-I, BP3, and insulin with uterine fibroids based on logistic regression are shown in. Age-adjusted and fully-adjusted models differ primarily because of adjustment for BMI in models of insulin and IGF-I, and adjustment for IGF-I in models of BP3. For IGF-I, there appeared to be an inverse association with fibroids in whites. When the association was examined by estimating prevalence differences, the estimates for the mid and upper tertiles of IGF-I compared with lower tertile were -11% (CI = -23% to 1%) and -9% (-23% to 4%), respectively. In fibroid size&x02013;specific models the reduction in fibroid development with IGF-I was seen for small and medium fibroids, but there was no evidence of reduced prevalence of large fibroids (). IGF-I was not associated with fibroids in blacks, and in an analysis of blacks and whites combined, theP-value for interaction by race was 0.07.
IGF-I production can be stimulated by growth hormone, and its actions include cell proliferation and inhibition of apoptosis.
Messenger ribonucleic acid expression of the insulin-like growth ctors and their binding proteins in uterine fibroids and myometrium.
For insulin, neither age-adjusted nor fully-adjusted analyses showed convincing evidence for an association with presence of fibroids. When size of the largest fibroid was examined, there appeared a tendency for elevated insulin to be protective for large fibroids in both ethnic groups, and the association was stronger in blacks (). The estimated reductions in prevalence of large fibroids for blacks in mid and upper tertiles of insulin compared with the lower tertile were -12% (-22% to -1%) and -16% (-27% to -5%), respectively. When we excluded women who had been diagnosed with diabetes (43 blacks and 9 whites), there was little change in the relative odds of fibroids associated with insulin, IGF-I, and BP3.
Glenn Heartwell managed field study data collection. Deborah Cousins coordinated data management. Darlene Dixon, Shannon Laughlin and Jack Taylor reviewed an earlier draft of the manuscript, and Sue Edelstein prepared the figures.
Characteristics of the study participants are shown in. Of the 585 blacks 427 had fibroids; of the 403 whites, 203 had fibroids. Insulin was log-normally distributed, and both the IGF-I and BP3 distributions were approximately normal. Blacks had higher levels of insulin and lower levels of BP3 than whites. As expected, insulin was highly correlated with BMI, IGF-I was inversely correlated with both age and BMI, and BP3 was correlated with IGF-I (see distributions and correlations ineAppendix, available with the online version of this article).
We hypothesized that increased circulating IGF-I and hyperinsulinemia would be associated with increased development of uterine fibroids. To test this hypothesis we measured IGF-I, BP3, and insulin in sting blood samples taken from women in the National Institute of Environmental Health Sciences (NIEHS) Uterine Fibroid Study, a study that recruited randomly selected 35&x02013;49-year-old members of an urban health plan and screened them for fibroids with ultrasound, thus identifying both clinically diagnosed and subclinical cases.
We evaluated the relation of IGF-I, BP3, insulin, and diabetes with uterine fibroids first using logistic regression, and then using a Bayesian multistate analysis.
BP3 may reduce IGF-I activity by preventing its binding to the receptor, but by binding IGF-I, it prolongs the half-life for IGF-I from minutes to hours. BP3 can also act independently of IGF-I, with antiproliferative effects.
Department of Health Care Sciences, George Washington University Medical Center, George Washington University, Washington, DC 20037, now at University of Virginia, Charlottesville, VA 22908
Circulating levels of insulin-like growth ctors, their binding proteins, and breast cancer risk.
We are sorry, but NCBI web applications do not support your browser, and may not function properly.More information here...
Insulin-like growth ctor&x02013;I (IGF-I) and insulin stimulate cell proliferation in uterine leiomyoma (fibroid) tissue. We hypothesized that circulating levels of these proteins would be associated with increased prevalence and size of uterine fibroids.
Insulin-like growth ctor&x02013;I (IGF-I) may be one of the growth ctors that plays an important role in the pathogenesis of fibroids.
IGF-I and insulin have both been shown to increase cellular proliferation of fibroid tissue in culture.
There are at least 6 high-affinity IGF binding proteins in the circulation that regulate the activity of IGF-I, the primary being binding protein 3 (BP3).
Plasma protein levels were divided into tertiles based on the combined sample of blacks and whites, and the lowest tertile was used as the reference group. Black women have a higher risk of fibroids and substantially different distributions of many covariates, so all analyses were performed separately for the 2 ethnic groups. Prior analyses of data from this study indicated that age, age of menarche, body mass index (BMI), physical activity, and number of deliveries after age 24 years were related to fibroid development.
reported elevated IGF-I expression in fibroid compared with normal myometrium, and upregulation of gene expression and protein has been seen in several subsequent studies.
In addition, hyperinsulinemia may stimulate increased ovarian hormone production, which might indirectly increase the development of fibroids.
Risk ctors for uterine leiomyoma: a practice-based case-control study. II. Atherogenic risk ctors and potential sources of uterine irritation.
Supported by the intramural program at the National Institute of Environmental Health Sciences with support from the Office of Research on Minority Health, National Institutes of Health, HHS.
Reproducibility of plasma steroid hormones, prolactin, and insulin-like growth ctor levels among premenopausal women over a 2- to 3-year period.
Bayesian analyses to examine the relation of IGF-I, insulin, and diabetes with tumor onset versus tumor progression controlled for the same ctors included in multivariable logistic analyses. IGF-I in whites was inversely associated with tumor onset (posterior probability, pp = 0.97), not tumor progression (pp = 0.45). Insulin in blacks was inversely associated with tumor progression (pp = 0.98), not tumor onset (pp = 0.50). Diabetes was marginally protective of tumor onset in blacks (pp = 0.90), but the association with progression was weaker (pp = 0.62).
[J Natl Cancer Inst. 2000]
Fibroid status was determined for most participants by a transabdominal and transvaginal ultrasound screening examination. Participants who had recently undergone an ultrasound examination at the clinic for clinical purposes (21%) were not asked to repeat an examination for the study. We used ultrasounds from the prior 2 years if they showed &x0201c;no fibroids&x0201d;, and ultrasounds from the prior 5 years if they showed fibroids. For these women fibroid data were abstracted from the clinic radiology reports. The study ultrasound examinations were performed by sonographers who were certified by the American Registry of Diagnostic Medical Sonographers and were trained for the study to collect and record consistent data on fibroids (minimum diameter of 0.5 cm). They were under the direct supervision of 1 radiologist with fellowship training in ultrasound, and each study was checked at its completion by this radiologist. The examinations were performed on ultrasound units ATL HDI 9, Acuson 128 XP, and Diasonics DRF 400 by using transabdominal (3.5&x02013;5.0 mHz) and transvaginal (5.0&x02013;7.0 mHz) ultrasound probes. Sonographers completed a data collection form designed for this study that included data on uterine size (length, width, anterior to posterior diameter), heterogeneity of the echo pattern (none, diffuse, or focal), and size of the largest fibroid. Any questionable sonograms were reviewed by a single radiologist. Those uteri with diffuse heterogeneity but no focal fibroids (39 whites and 76 blacks) were categorized as having fibroids, but statistical analyses were also repeated without these women, and results did not change. For 18 participants who did not complete their ultrasound screening examinations and 1 whose ultrasound examination was indeterminate, we accepted self-report of a prior diagnosis. We did not rely on self-report of &x0201c;no fibroids&x0201d; because undiagnosed fibroids are common; about half of the undiagnosed women in our study were found to have fibroids at ultrasound screening.
Expression profile of tuberin and some potential tumorigenic ctors in 60 patients with uterine leiomyomata.
Participants were 35&x02013;49-year-old, randomly selected members of an urban health plan who were enrolled in 1996&x02013;1999. Premenopausal participants were screened for fibroids with ultrasound. Fasting blood samples were collected. Associations between fibroids and diabetes, plasma IGF-I, IGF binding protein 3 (BP3), and insulin were evaluated for blacks (n = 585) and whites (n = 403) by using multiple logistic regression.
To our knowledge no prior study has examined the association between circulating levels of BP3 and fibroid status.
Insulin and IGF-I have similar growth-promoting activity, and both have weak binding affinity to the others receptor.
demonstrated estrogen-dependent IGF-I upregulation and its linkage to transcription ctors that increase the rate of cell cycle transition, thus providing a detailed description of IGF-I proliferative and anti-apoptotic effects in fibroids.
Uterine leiomyomata, commonly called fibroids, are the leading indication for hysterectomy in the United States.
Modulation of insulin-like growth ctor (IGF) action by IGF-binding proteins in normal, benign, and malignant smooth muscle tissues.
In situ expression may be a major difference between breast tissue and fibroid tissue. Few breast cancer cell lines express IGF-I.
This analysis was also limited to premenopausal women with an intact uterus. This excluded a subset of women who had previously had hysterectomies for fibroids, and more blacks were excluded than whites. If IGF-I and insulin were related to more severe, early-onset disease, we could miss such an association by limiting to the premenopausal sample. However, when we examined tumor size, there was no suggestion that the exposures of interest increased the risk of large tumors, so this selection may have had little effect on results.
The NIEHS clinical chemistry laboratory measured IGF-I and BP3 in plasma that had been stored at -80&x000b0;C. IGF-I was measured by extraction using radioimmunoassay kits (Nichols Institute Diagnostics San Juan Capistrano, CA). BP3 was measured by immunoradiometric assay kits (Diagnostic Systems Laboratories, Webster, TX). Insulin was measured in plasma at the Duke University Clinical and Research Laboratory. All intra- and interassay coefficients of variation were less than 10%.
The condition is especially common for blacks, a group with estimated cumulative hysterectomy rates for fibroids of 20% by age 45.
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth ctor receptors.
2012-2-1 下午12:18:58
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Tumour4046

redpajama_set_name: RedPajamaCommonCrawl


text:
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Konrad Hinsen's Blog
The structure and interpretation of scientific models
2020-12-10 :: computational science
It is often said that science rests on two pillars, experiment and theory. Which has lead some to propose one or two additional pillars for the computing age: simulation and data analysis. However, the real two pillars of science are observations and models. Observations are the input to science, in the form of numerous but incomplete and imperfect views on reality. Models are the inner state of science. They represent our current understanding of reality, which is necessarily incomplete and imperfect, but understandable and applicable. Simulation and data analysis are tools for interfacing and thus comparing observations and models. They don't add new pillars, but transforms both of them. In the following, I will look at how computing is transforming scientific models.
Empirical models
The first type of scientific model that people construct when figuring out a new phenomenon is the empirical or descriptive model. Its role is to capture observed regularities, and to separate them from noise, the latter being small deviations from the regular behavior that are, at least provisionally, attributed to imprecisions in the observations, or to perturbations to be left for later study. Whenever you fit a straight line to a set of points, for example, you are constructing an empirical model that captures the linear relation between two observables. Empirical models almost always have parameters that must be fitted to observations. Once the parameters have been fitted, the model can be used to predict future observations, which is a great way to test its generality. Usually, empirical models are constructed from generic building blocks: polynomials and sine waves for constructing mathematical functions, circles, spheres, and triangles for geometric figures, etc.
The use of empirical models goes back a few thousand years. As I have described in an earlier post, the astronomers of antiquity who constructed a model for the observed motion of the Sun and the planets used the same principles that we still use today. Their generic building blocks were circles, combined in the form of epicycles. The very latest variant of empirical models is machine learning models, where the generic building blocks are, for example, artificial neurons. Impressive success stories of machine learning models have led some enthusiasts to proclaim the end of theory, but I hope to be able to convince you in the following that empirical models of any kind are the beginning, not the end, of constructing scientific theories.
The main problem with empirical models is that they are not that powerful. They can predict future observations from past observations, but that's all. In particular, they cannot answer what-if questions, i.e. make predictions for systems that have never been observed in the past. The epicycles of Ptolemy's model describing the motion celestial bodies cannot answer the question how the orbit of Mars would be changed by the impact of a huge asteroid, for example. Today's machine learning models are no better. Their latest major success story as I am writing this is the AlphaFold predicting protein structures from their sequences. This is indeed a huge step forward, as it opens the door to completely new ways of studying the folding mechanisms of proteins. It is also likely to become a powerful tool in structural biology, if it is actually made available to biologists. But it is not, as DeepMind's blog post claims, "a solution to a 50-year-old grand challenge in biology". We still do not know what the fundamental mechanisms of protein folding are, nor how they play together for each specific protein structure. And that means that we cannot answer what-if questions such as "How do changes in a protein's environment influence its fold?"
Explanatory models
The really big success stories of science are models of a very different kind. Explanatory models describe the underlying mechanisms that determine the values of observed quantities, rather than extrapolating the quantities themselves. They describe the systems being studied at a more fundamental level, allowing for a wide range of generalizations.
A simple explanatory model is given by the Lotka-Volterra equations, also called predator-prey equations. This is a model for the time evolution of the populations of two species in a preditor-prey relation. An example is shown in this plot (Lamiot, CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Commons):
An empirical model would capture the oscillations of the two curves and their correlations, for example by describing the populations as superpositions of sine waves. The Lotka-Volterra equations instead describe the interactions between the population numbers: predators and prey are born and die, but in addition predators eat prey, which reduces the number of prey in proportion to the number of predators, and contributes to a future increase in the number of predators because they can better feed their young. With that type of description, one can ask what-if questions: What if hunters shoot lots of predators? What if prey are hit by a famine, i.e. a decrease in their own source of food? In fact, the significant deviations from regular periodic change in the above plot suggests that such "outside" events are quite important in practice.
Back to celestial mechanics. The decisive step towards an explanatory model was made by Isaac Newton, after two important preparatory steps by Copernicus and Kepler, who put the Sun at the center, removing the need for epicycles, and described the planets' orbits more accurately as ellipses. Newton's laws of motion and gravitation fully explained these elliptical orbits and improved on them. More importantly, they showed that the fundamental laws of physics are the same on Earth and in space, a fact that may seem obvious to us today but wasn't in the 17th century. Finally, Newton's laws have permitted the elaboration of a rich theory, today called "classical mechanics", that provides several alternative forms of the basic equations (in particular Lagrangian and Hamiltonian mechanics), plus derived principles such as the conservation of energy. As for what-if questions, Newton's laws have made it possible to send artefacts to the moon and to the other planets of the solar system, something which would have been unimaginable on the basis of Ptolemy's epicycles.
So far I have cited two explanatory models that take the form of differential equations, but that is not a requirement. An example from the digital age is given by agent-based models. There is, however, a formal characteristic that is shared by all explanatory models that I know, and that distinguishes them from empirical models: they take the form of specifications.
Specifications and equations vs. algorithms and functions
Let's look at a simple problem for illustration: sorting a list of numbers (or anything else with a well-defined order). I have a list L, with elements L[i], i=1..N where N is the length of the list L. What I want is a sorted version which I will call sorted(L). The specification for sorted(L) is quite simple:
sorted(L) is a list of length N.
For all elements of L, their multiplicities in L and sorted(L) are the same.
For all i=1..N-1, sorted(L)[i] ≤ sorted(L)[i+1].
Less formally: sorted(L) is a list with the same elements as L, but in the right order.
This specification of sorted(L) is complete in that there is one unique list that satisfies it. However, it does not provide much help for actually constructing that list. That is what a sorting algorithm provides. There are many known algorithms for sorting, and you can learn about them from Wikipedia, for example. What matters for my point is that (1) given the specification, it is not a trivial task to construct an algorithm, (2) given a few algorithms, it is not a trivial task to write down a common specification that they satisfy (assuming of course that it exists). And that means that specifications and algorithms provide complementary pieces of knowledge about the problem.
In terms of levels of abstraction, specifications are more abstract than algorithms, which in turn are more abstract than implementations. In the example of sorting, the move from specification to algorithm requires technical details to be filled in, in particular the choice of a sorting algorithm. Moving on from the algorithm to a concrete implementation involves even more technical details: the choice of a programming language, the data structures for the list and its elements, etc.
In the universe of continuous mathematics, the relation between equations (e.g. differential equations) and the functions that satisfy them is exactly the same as the relation between specifications and algorithms in computation. Newton's equations can thus be seen as a specification for the elliptical orbits that Kepler had described a bit earlier. Like in the case of sorting, it is not a trivial task to derive Kepler's elliptical orbits from Newton's equations, nor is it a trivial task to write down Newton's equations as the common specification of all the (approximatively) elliptical orbits in the solar system. The two views of the problem are complementary, one being closer to the observations, the other providing more insight.
One reason why specifications and equations are more powerful is that they are modular. Two specifications combined make up another, more detailed, specification. Two equations make up a system of equations. An example is given my Newton's very general law of motion, which is extended by his law of gravitation to make a model for celestial mechanics. The same law of motion can be combined with different laws defining forces for different situations, for example the motion of an airplane. In contrast, there is no way to deduce anything about airplanes from Kepler's elliptical planetary orbits. Functions and algorithms satisfy complete specifications, and conserve little information about the components from which this complete specification was constructed.
A challenge for computational science
Computational science initially used computers as a tool for applying structurally simple but laborious computational algorithms. The focus was on efficient implementations of known algorithms, later also on developing efficient algorithms for solving well-understood equations. The steps from specification to algorithm to implementation were done by hand, with little use of computational tools.
That was 60 years ago. Today, we have computational models that are completely unrelated to the mathematical models that go back to the 19th century. And when we do use the foundational mathematical models of physics and chemistry, we combine them with concrete systems specifications whose size and complexity requires the use of computational tools. And yet, we still focus on implementations and to a lesser degree on algorithms, neglecting specifications almost completely. For many routinely used computational tools, the implementation is the only publicly accessible artefact. The algorithms they implement are often undocumented or not referenced, and the specifications from which the algorithms were derived are not written down at all. Given how crucial the specification level of scientific models has been in the past, we can expect to gain a lot by introducing it into computational science as well.
To do so, we first need to develop a new appreciation for scientific models as distinct from the computational tools that implement them. We then need to think about how we can actually introduce specification-based models into the workflows of computational science. This requires designing computational tools that let us move freely between the three levels of specification, algorithm, and implementation. This is in my opinion the main challenge for computational science in the 21st century.
Some readers may have recognized that the title of this post is a reference to two books, Structure and Interpretation of Computer Programs (with a nice though inofficial online version) and Structure and Interpretation of Classical Mechanics (also online). The second one is actually somewhat related to the topic of this post: it is a textbook on classical mechanics that uses computational techniques for clarity of exposition. More importantly, both books focus on inducing a deep understanding of their topics, rather than on teaching superficial technical details. This humble blog post cannot pretend to reach that level, of course, but its goal is to spark developments that will culminate in textbooks of the same quality as its two inspirations.
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This blog starts in November 2015. For older posts, see my old WordPress blog.
computer-aided research


It looks like that after I reassembled my phone, don't know why.
Spots won't go away, they're burned into the lcd pages. If you swapped lcds it will fix this, see this all the time.
It won't go away it's been there for months I just haven't posted about it.
Bioxed zal eeuwig dankbaar zijn.


text:
Q: Is there an alternative characterisation of vector bundles with vanishing characteristic classes? This question came up yesterday during our index theory seminar.
Let $M$ be a 1-connected smooth manifold and let $E \to M$ be a finite-rank complex vector bundle over $M$.  If all the Chern classes of $E$ vanish, what else can one say about $E$?  In other words, is there an alternative characterisation of such $E$?
(For a similar question in the case of $M$ having nontrivial fundamental group, see this previous question.)

A: Since no one has mentioned it yet, let me point out one possibly interesting observation.  If the base manifold $M$ is compact and has no torsion in its integral cohomology, then a vector bundle $E$ with vanishing Chern classes is stably trivial.  This was pointed out to me by Robert Lipshitz.  The reason is as follows: from looking at the Atiyah-Hirzebruch spectral sequence, one can see that there can't be any torsion in the complex K-theory of $M$.  Looking at the Chern character, one concludes that $[E]$ must be trivial in $\widetilde{K}^0(M)$, i.e. $E$ is stably trivial.

redpajama_set_name: RedPajamaStackExchange


text:
Q: How to utilise google maps to replicate functionality similar to rightmoves' draw-a-search? I know this will be a complex solution. I would appreciate it if you could push me in the right direction.
Please have a look at http://www.rightmove.co.uk/draw-a-search.html. I am interested in finding out how this is possible. what steps do I have to take to achieve this?

A: There's quite a few things going on here.
You need to have event listeners for when the user clicks on the map.
You need to place markers where they click.
You need to draw two types of polylines; the static type connecting two markers, and the dynamic dotted line as they move the cursor or drag a marker.
When you've closed up the polygon, you need to make your search only return properties inside that shape (although they're actually doing it within X miles radius from that shape).
They're also inserting markers half-way along the lines that you can drag - this will require the geographical library, using the interpolate function.


text:
Intellectual Thoughts !!!!!
FMC Corporation Announces Separation into Two Independent Public Companies
New FMC will be comprised of FMC Agricultural Solutions and FMC Health and Nutrition segments
FMC Minerals will be comprised of the current FMC Minerals segment, which includes the Alkali Chemicals and Lithium businesses
PHILADELPHIA, March 10, 2014 /PRNewswire/ -- FMC Corporation (NYSE: FMC) today announced plans to separate into two independent public companies, "New FMC," which will be comprised of FMC's Agricultural Solutions and Health and Nutrition segments and "FMC Minerals," which will be comprised of FMC's current Minerals segment. The company expects the separation, which remains subject to final board approval and other customary conditions, will take the form of a tax-free distribution of shares to existing FMC shareholders. FMC Corporation expects to complete the separation in early 2015, and each company is expected to be listed on the New York Stock Exchange.
Pierre Brondeau, FMC Corporation president, CEO and chairman, said: "FMC has proactively managed its portfolio during the last four years as part of Vision 2015, including a realignment of our reporting segments early last year. Our decision to separate into two independent companies is a natural progression of our strategy. We believe that creating two companies, each with its own publicly-listed equity, will enable the management of each company to pursue its own strategy. This will give each company greater focus on the success factors that are most important to its business and allow the adoption of a capital structure that is appropriate to its business profile.
"The creation of two independent companies will deliver meaningful benefits to each of the businesses, the communities in which we operate and all of our stakeholders. Our customers will continue to have collaborative relationships with financially strong organizations that are focused on meeting their needs, and our employees will have new career opportunities."
New FMC
New FMC, comprised of FMC Agricultural Solutions and FMC Health and Nutrition segments, will be a technology-based and customer-driven company with deep application expertise. Based on the midpoint of the company's February 2014 outlook, combined revenue and earnings for the Agricultural Solutions and Health and Nutrition segments are expected to be approximately $3.35 billion, up 16 percent over 2013, and $815 million, up 15 percent over 2013, respectively. New FMC is expected to maintain a strong balance sheet and financial policies consistent with FMC Corporation's current credit rating.
FMC Agricultural Solutions is a science-based business, serving growers worldwide. Growers look to FMC Agricultural Solutions for innovative crop-protection products developed from science-based innovation, field development, applications expertise and toxicology that, on a crop-by-crop, region-by-region basis, enhance quality and yield.
FMC Health and Nutrition develops products from natural sources that provide texture, stability and natural color solutions for food applications, while also producing binders, coatings and high-purity, high-concentration omega-3 for pharmaceutical and nutraceutical applications. Customers rely on FMC Health and Nutrition for its technical excellence, innovative products and collaborative R&D approach.
FMC Minerals
FMC Minerals will be comprised of the current FMC Minerals segment, which includes the Alkali Chemicals and Lithium businesses. Based on the midpoint of the company's February 2014 outlook, revenue and earnings for the FMC Minerals segment are expected to be approximately $1.0 billion, up 7 percent over 2013, and $153 million, up 19 percent over 2013, respectively. FMC Minerals is expected to generate strong cash flow and have the financial flexibility to pursue select investment opportunities. FMC Minerals will maintain FMC Corporation's disciplined approach to capital deployment and will continue to focus on sustainable, safe and ethical extraction of minerals, process efficiencies, and manufacturing and customer service excellence.
Both the Alkali Chemicals and Lithium businesses are structurally-advantaged minerals businesses, with cost-advantaged operations. Both businesses compete in attractive markets. The Alkali Chemicals business is the largest global producer of natural soda ash, using low-cost technologies to extract trona ore to produce soda ash and related products used in the glass, chemical processing and detergent industries. The Lithium business is the only brine-to-metals producer with a broad global product portfolio, selling into the energy storage, pharmaceuticals, polymers and industrial markets. Underlying market demand for lithium remains strong, driven by growth in energy storage from electric vehicle adoption and other applications.
Bank of America Merrill Lynch and Goldman Sachs are acting as financial advisors to FMC Corporation on the proposed transaction and Wachtell, Lipton, Rosen & Katz is serving as legal advisor to the company.
source : FMC site
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text:
Foreign Phisher Sentenced to 50 Months in U.S. Prison
Source: Threat Level from Wired.com
"The first foreigner convicted of phishing in the United States was sentenced to 50 months in federal prison Monday."
Vast Spy System Loots Computers in 103 Countries
Source: NYTimes.com
Researchers have obtained an inside look into a vast, strategic network of computers which have been compromised in targeted attacks (rather than the usual opportunistic attacks). The network consists of "at least 1,295 computers in 103 countries, including many belonging to embassies, foreign ministries and other government offices, as well as the Dalai Lama's Tibetan exile centers in India, Brussels, London and New York." The back doors in the computers are being controlled by computers based almost exclusively in China, leading to speculation that the Chinese government is behind the espionage.
'Cybercrime exceeds drug trade' myth exploded
Ed Amoroso, Senior Vice President and Chief Security Officer of AT&T, recently told a Congressional Committee that cybercrime was a trillion dollar a year business. This was supposed to be based on an FBI report, but the FBI has made no such claim. Instead, it seems to be more of an urban myth. This article attempts to put some perspective on the inflated claim, and find out how the myth got started.
'The Analyzer' Hack Probe Widens; $10 Million Allegedly Stolen From U.S. Banks
Threat Level has an interesting article covering the cybercrime activities of Ehud Tenenbaum, also known as "The Analyzer", who was arrested in Canada last year for allegedly stealing about $1.5 million from Canadian banks. He also allegedly hacked two U.S. banks, a credit and debit card distribution company and a payment processor in what U.S. authorities are calling a global "cashout" conspiracy. The U.S. hacks have resulted in at least $10 million in losses, and are just part of a larger international conspiracy to hack financial institutions in the United States and abroad.
Web Fraud 2.0: Data Search Tools for ID Thieves
Source: Security Fix
"Cyber crooks are providing cheap, instant access to detailed consumer databases, offering identity thieves the ability to find missing data as they compile dossiers on targeted individuals." "It's unclear how these sites are obtaining this kind of information. It may be that they're relying on insiders at companies with access to this data. Alternatively, perhaps the services are making use of using stolen credentials needed to access sensitive online databases. More likely, it is a mixture of both."
Hacked page hauls estimated at $10,000 a day
Fake antivirus products continue to prove themselves the Next Big Thing in cybercrime. Security firm Finjan estimates that search engine gaming techniques on popular search terms can earn the perpetrators more than ten thousand US dollars per day in referral fees.
Rogue Antivirus Distribution Network Dismantled
Hot on the heels of a report on TrafficConverter2.biz by Security Fix earlier this week, the site has lost its ability to receive payments through Visa and MasterCard thanks to investigations being conducted by those companies. Traffic Converter is an affiliate program for the fake antivirus program AntiVirus2009 and others. These programs extort money out of those parties unfortunate enough to find them installed on their computer by throwing up increasingly alarming error messages, and requesting that the user pay for the "full version" of the software to fix the problem.
Costly Online Organ-Transplant Scam Results in Death, Arrest
Advance fee fraud is nothing new, but this could well be a new low. The site liver4you.org sells organ transplants, or so it claims. A Canadian man paid $70,000 and was told he'd receive a liver transplant at a hospital in the Philippines. There was no liver, and no transplant, and the man died in the hospital where he thought his life would be saved. Jerome Feldman, age 67, has been arrested on charges of operating the scam.
Antivirus2009 Holds Victim's Documents for Ransom
The fake anti-virus program Antivirus2009 is now using its deceptive error messages to frighten users into downloading a program called FileFixerPro, under the pretext that certain files in the "My Documents" folder are corrupt. Antivirus2009 actually encrypts the files in question, and FileFixerPro will decrypt them only after a $50 fee is paid. File encryption has been used in the past, attracting the name "ransomware", but this is perhaps the first time that the technique has been used stealthily in conjunction with "scareware" like Antivirus2009, as opposed to blatant blackmail.
2008 fraud figures announced by APACS
Source: APACS
The UK payments association, APACS, has announced UK fraud figures for 2008. "The two main areas of fraud were on transactions not protected by chip and PIN: specifically internet, phone and mail order fraud; and fraud abroad - committed by criminals using stolen UK card details in countries yet to upgrade to chip and PIN - which has nearly doubled in two years." "Online banking fraud losses totalled £52.5m in 2008 – a 132 per cent increase from 2007 losses. Although phishing incidents continue to increase, online banking customers are increasingly being targeted by malware..."
Hacking iTunes Gift Cards, and an iTunes Update
There is some question as to whether the iTunes voucher code system has actually been broken (as reported recently). The basis for doubt is that the vouchers must be activated at the point of sale before they can be redeemed. Even so, the iTunes codes offered for sale are definitely working. One theory is that the codes are simply being purchased online using stolen credit card data, then on-sold.
Police in Romania detain 20 alleged hackers
Source: International Herald Tribune
Police in Romania on Wednesday detained 20 people on suspicion of phishing. The phishing incidents in question targeted victims in Italy and Spain.
The Chinese iTunes Gift Voucher Trick
Source: Outdustry
Hackers have cracked the iTunes gift voucher code and are selling the codes so generated to Chinese counterfeiters who then on-sell to the public. Current market rates result in $200 gift card codes being obtainable for around $2.60.
German cops bust cybercrime forum
"German police have arrested several members of a hacking forum linked to the distribution of Trojan horse software that infected 80,000 computers."
Foreign Phisher Sentenced to 50 Months in U.S. Pri...
'The Analyzer' Hack Probe Widens; $10 Million Alle...
Costly Online Organ-Transplant Scam Results in Dea...


text:
Q: Create a Pivot table with PHP and MYSQL - Current displayed table repeats labels I am hoping to get some help on how I can modify my PHP code to show a pivot table in HTML.  Right now it creates a table with Location, Component, and Count on each row, but I would rather have Location as the column header and component as the row header with count being the data.
Here is my code:
function print_table_commodity_location_count_inbd_pivot(){
    $query_items = "SELECT `tbl_origin_dest`.`name` AS 'Location',
                    `tbl_component`.`component_name` AS 'Component',
                    COUNT(`tbl_entry_item`.`entry_item_id`) AS 'Comp_Count'
            FROM tbl_entry
                LEFT JOIN tbl_entry_item ON `tbl_entry`.`entry_id`=`tbl_entry_item`.`entry_id`
                LEFT JOIN tbl_customer ON `tbl_entry`.`customer_id`=`tbl_customer`.`customer_id`
                LEFT JOIN tbl_serv_prov ON `tbl_entry`.`serv_prov_id`=`tbl_serv_prov`.`serv_prov_id`
                LEFT JOIN tbl_origin_dest ON `tbl_entry`.`location`=`tbl_origin_dest`.`id`
                LEFT JOIN tbl_project ON `tbl_entry`.`project_id`=`tbl_project`.`project_id`
                LEFT JOIN tbl_component ON `tbl_entry_item`.`component_id`=`tbl_component`.`component_id`
            WHERE `tbl_entry`.`in_out_type`='I' AND `outbound_entry_id` IS NULL AND `outbound_entry_item_id` IS NULL
            GROUP BY `tbl_origin_dest`.`name`,
                    `tbl_component`.`component_name`";

    $result_items=mysql_query($query_items);
    $num_items=mysql_numrows($result_items);

    echo "

                Location
                Component
                Inventory Count

";
    $x=0;
    while ($x < $num_items) {
        $x1=mysql_result($result_items,$x,"Location");
        $x2=mysql_result($result_items,$x,"Component");
        $x3=mysql_result($result_items,$x,"Comp_Count");

        echo "

            ".$x1."
            ".$x2."
            ".$x3."

";

        $x++;
    }
    echo "
";
}

Results as of right now show
Location - Component - Count for each line.

A: function print_table_commodity_location_count_inbd_pivot(){
    $query_items = "SELECT `tbl_origin_dest`.`name` AS 'Location',
                    `tbl_component`.`component_name` AS 'Component',
                    COUNT(`tbl_entry_item`.`entry_item_id`) AS 'Comp_Count'
            FROM tbl_entry
                LEFT JOIN tbl_entry_item ON `tbl_entry`.`entry_id`=`tbl_entry_item`.`entry_id`
                LEFT JOIN tbl_customer ON `tbl_entry`.`customer_id`=`tbl_customer`.`customer_id`
                LEFT JOIN tbl_serv_prov ON `tbl_entry`.`serv_prov_id`=`tbl_serv_prov`.`serv_prov_id`
                LEFT JOIN tbl_origin_dest ON `tbl_entry`.`location`=`tbl_origin_dest`.`id`
                LEFT JOIN tbl_project ON `tbl_entry`.`project_id`=`tbl_project`.`project_id`
                LEFT JOIN tbl_component ON `tbl_entry_item`.`component_id`=`tbl_component`.`component_id`
            WHERE `tbl_entry`.`in_out_type`='I' AND `outbound_entry_id` IS NULL AND `outbound_entry_item_id` IS NULL
            GROUP BY `tbl_origin_dest`.`name`,
                    `tbl_component`.`component_name`";

    $result_items=mysql_query($query_items);
        $locationArray = array();
        $components = array()
        echo '

	';
        $locations = array();
                while($row = mysql_fetch_assoc($result_items)){
        //create an array with all the locations
        if(!in_array($row['Location'], $locations){
        $locations[] = $row['Location'];
        }
        //create an array for every component and the count at a location
        $components[$row['Component']][$row['Location']] = $row['Comp_count'];

        }
            //create the first row columnns (header)
            foreach($locations as $location){
            echo ''.$location.'	'
            }
            echo '
';
            foreach($components as $component => $componentLocations){
                echo '
'.$component.'	';
                foreach($locations as $loc){
                    //if there is no component at this location
                if(!array_key_exists($loc, $componentLocations)){
                echo '0	';
                }else{
                echo ''.$componentLocations[$loc].'	';
                }
                }
            echo .'
';
            }
     echo '

';

That should be it


If you have any questions about this product by Fafnir, contact us by completing and submitting the form below. If you are looking for a specif part number, please include it with your message.
(100 Count) Simpson Strong-Tie LU28R-18 - 2 x 8 Rough Face Mount Hanger 18 Ga.


text:
Alwasat - Cairo Tue 03 Apr 2018, 08:48 PM
Reuters- Three foreign powers who have shaped Syria's civil war - Iran, Russia and Turkey - will discuss ways to wind down the fighting on Wednesday despite their involvement in rival military campaigns on the ground.
The leaders of the three countries will meet in Ankara for talks on a new constitution for Syria and increasing security in "de-escalation" zones across the country, Turkish officials say.
The Syria summit brings together two powers which have been President Bashar al-Assad's most forceful supporters, Iran and Russia, with one of his strongest opponents, Turkey.
Cooperation between the rival camps raised hopes of stabilizing Syria after seven years of conflict in which 500,000 people have been killed and half the population displaced.
But the violence has raged on, highlighting strategic rifts between the three countries who, in the absence of decisive Western intervention, hold Syria's fate largely in their hands.
Syria's army and Iran-backed militias, with Russian air power, have crushed insurgents near Damascus in eastern Ghouta - one of the four mooted "de-escalation zones".
Turkey, which sharply criticized the Ghouta offensive, waged its own military operation to drive Kurdish YPG fighters from the northwestern Syrian region of Afrin. It has pledged to take the town of Tel Rifaat and push further east, angering Iran.
"Whatever the intentions are, Turkey's moves in Syria, whether in Afrin, Tel Rifaat or any other part of Syria, should be halted as soon as possible," a senior Iranian official said.
Iran has been Assad's most supportive ally throughout the conflict. Iran-backed militias first helped his army stem rebel advances and, following Russia's entry into the war in 2015, turn the tide decisively in Assad's favor.
A Turkish official said Ankara will ask Moscow to press Assad to grant more humanitarian access in Ghouta, and to rein in air strikes on rebel-held areas. "We expect ... Russia to control the regime more," the official told reporters this week.
Tunisia raises fuel prices 3% for second time in ...
Russia, Iran and Turkey struggle to find common ...
Libya Quartet backs elections this year, offers ...
Algeria to end import ban on mobiles, food, home ...
North Korea says it rejects Libya-style ...
Italy cannot be 'Europe's refugee camp': Matteo ...
British government: We will continue to cooperate ...
Italy prevents 42 migrants from entering ...


text:
Health Practice & Services Collection
This collection includes 68 peer-reviewed journals published by SAGE and participating societies, encompassing over 84,056 articles. Complimentary access back to 1999, where available, is included while the current collection subscription is maintained.
2023 Health Practice & Services Collection Title List
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Q: Eclipse refresh workspace after running external tool I am sitting on a problem of that I am afraid I am not able to solve without your support and so far I haven't found any information to solve it.
What I want
In Eclipse I want to have something like the "Java Application" launch configuration (build the application then run it) for CoffeeScript in a Node.js environment.
What I have
I have a launch configuration which uses the coffee compiler to generate the Javascript resources and a launch configuration to start the generated Javascript in Node.js. The automatisation (first compiling then running) do I realize with a launch group in which I first run the compile configuration, wait until the compile process terminates and then try to run the Javascript in Node.js.
The configuration of the launch group
What is the problem?
The problem is, that the Node.js configuration can't find the Javascript resources of the compile configuration. I think that this is caused by Eclipses way of storing resources. Is there any way to enforce a refresh of the workspace within a launch configuration ?
I am using Eclipse Java EE IDE for Web Developers with the Nodeclipse CoffeeScript Viewer (Editor before Eclipse 4.3.1) plugin.

*

*Eclipse Version: 2018-09 (4.9.0)

*Eclipse Build id: 20180917-1800

Thank you for your help.

A: The individual Launch Configuration for your 'compile coffeescript' launch should have a 'Refresh' tab where you can select 'Refresh resources upon completion'. Once this is selected you can choose which resources to refresh.


When your not-for-profit desperately needs a new facility, costly equipment or an endowment, a capital campaign can be the best way to raise funds. But to be successful, a campaign requires strong leadership, extensive planning and dedicated participants.
Time to attend planning sessions and fundraising activities.
Most capital campaigns require a small army to raise funds through direct mail, email solicitations, direct solicitations and special events. In addition to staff and board members, reach out to current volunteers, like-minded community groups and clients who've benefited from your services.
Also pay attention to how you craft your message. Potential donors must see your organization as capable and strong, but also as the same group they've championed for years. Instead of focusing on what donations will do for your nonprofit, show potential donors the impact on their community.
You'll know you've reached your goal when you've raised a certain dollar amount. But don't forget about other measures of success, such as return on investment or percentage of past donors contributing. We can help you identify the most valuable metrics.


My site is a subscription music platform that offers custom music channels for background music in stores (Restaurants, Retails and Hotels are the target clients). Instead of creating Music Genre Channels, we have developed a different concept of Music channels focused in types of brands and target... For example we have an "International Restaurant music Channel" or a "Fashion Retail for Teen Girls music channel"... and so on.
This site is translatable to 3 different languages (using WPML plugin)... and the subscription process is handled with S2member plugin.
3) Clear Message: The user should understand what the page does in just a second after he arrives.
1) The Footer area: I really need to improve this area... its not pretty right now... I will need to add a language switcher there. As I might add many languages... the best would be a dropdown menu.
1) The introductory Text with a call to action button so the user register to try the site for free during 30 days.
2) The Portfolio Gallery of the home: Here i need many changes... for example... the template doesn´t come with the name of the portfolios by default... you need to mouse over to know what is the title of every portfolio and in my case this is not good... and also a play icon in the middle of every music channel thumbnail will help to let users understand that this is a music website. I have given just ideas... I am sure you can give me better ones! I have also changed the original template to achievet this... but if you find a better way to show it... perfect!
I would like to have a "music app" oriented design here. Many users will come from an organic search from Google that have never visited my site and I would like to impress the user with the beauty of the site and also introduce what my site does in the first view of the page (without scrolling).
2) A space for a nice image (it can be in any place... its not mandatory to add it inmediately after the player... it can be outside the first screen).
5) A nice "Back to Channels Panel" button.
Here is a link of the site right now: [login to view URL] ... but as I am a little bit stuck... I came to Freelancer so to hire someone that can give me best ideas on how to improve the site and launch good. My idea is to continue hiring for further improvements to the best designers.
Please Dont send an image with only a messsage saying: "I WILL DO IT" or stuff like this. I will reject those kind of proposals and will consider them as spam.
hello sir any feedback on #3 ?
Thanks Jesse, i will be waiting for it!


text:
naturalnews.com printable article
Originally published February 24 2008
The North American Union - You Could Be Voting Your Rights Away
by Barbara L. Minton
(NaturalNews) One issue that is conspicuously absent from the rhetoric of the presidential candidates is the North American Union (NAU). The questions of immigration and border security are frequently raised and the candidates claim to realize the need for a clear immigration policy and effort to secure the borders of the United States. Yet when you begin to understand the purposes of the North American Union and the agenda of its proponents, you will understand why this will never happen. And you may also begin to see that you are being manipulated by the major candidates.
The NAU, a goal of the Council on Foreign Relations, follows a plan laid out by Robert Pastor. It is currently promoted by the Bush administration to expand the size and scope of NAFTA (North American Free Trade Agreement). Its goal is to effectively create a North American trading block by erasing the borders between the U.S., Mexico and Canada resulting in free, unimpeded movement of people and goods across those borders. It is also a political union that would integrate the governments of the three countries. And clearly it is an economic union with the intention of equalizing the wages and standard of living of all but the ruling elitists.
Sounds a lot like the European Union, doesn't it? There are even plans for a common currency called the amero. But there is one glaring difference. The people of the United States have never been asked if they want to become integrated with Mexico and Canada, two countries of enormously different laws, culture, economic systems, standards of living, and acceptance of the role of government.
The European Union followed years of open debate at all levels, intense coverage of the ramifications and implications in major media, and a vote of the people.
History and Origins of NAU
President Bush signed the Declaration of Quebec City in April, 2001, making a "commitment to hemispheric integration". After Hugo Chavez of Venezuela voiced opposition, these plans were scaled back to include only North America.
The Independent Task Force on North America, a project organized by the Council on Foreign Relations and co-chaired by Robert Pastor, was launched in October, 2004. This group published two documents: Trinational Call for a North American Economic and Security Community by 2010 (March, 2005), and its final report Building a North American Community (May, 2005). This Task Force had as its central recommendation the establishment by 2010 of a North American economic and security community. The boundaries of this community would be defined by a common external tariff and outer security perimeter. Also called for is the replacing of all three branches of the US government with a North American version effectively ending U.S. representative government.
In March 2005, at their summit meeting in Waco, Texas; Bush, President Fox of Mexico and Prime Minister Martin of Canada issued a joint statement announcing the Security and Prosperity Partnership of North America (SPP). The creation of this agreement was never submitted to Congress for discussion or decision. The U.S. Department of Commerce merely created a new division implementing working groups to advance a North American Union agenda. This agenda included movement of goods, finances, e-commerce, environment, business facilitation, food and agriculture, and health. The result is an action agreement to be implemented immediately and directly by regulations, without any envisioned Congressional debate or oversight.
In September 2006, Rep. Virgil Goode (Va), Rep. Ron Paul (Tx), Rep. Walter Jones (NC), and Rep. Tom Tancredo (Co) introduced House Concurrent Resolution 487, expressing concerns about the NAU. Resolution was passed by the House of Representatives with the Senate concurring that the U.S. should not enter into a North American Union with Mexico and Canada; the U.S. should not engage in the construction of the NAFTA Superhighway System, and the President should indicate strong opposition to these or any other proposals that threaten the sovereignty of the U.S.
In October 2006, Congressman Paul formally denounced the formation of the SPP and the plans for the North American Union and the SPP as "an unholy alliance of foreign consortiums and officials from several governments". Paul says that the real issue raised by the SPP is nation sovereignty. "Once again, decisions that affect millions of Americans are not being made by those Americans themselves, or even by their elected representatives in Congress. Instead, a handful of elites use their government connections to bypass national legislatures and ignore our Constitution – which expressly grants Congress the sole authority to regulate international trade." In this speech Paul predicts that the NAU will become a sleeper issue for the 2008 election, stating that "any movement toward a NAU diminishes the ability of average Americans to influence the laws under which they must live."
A report authored by the Center for Strategic and International Studies (CSIC) was presented to all three governments in September 2007. CSIC is a political influence group of internationalists who have crafted many of the government policies of the past several years. At the core of the report is its plan for America's future, North American "economic integration" and "labor mobility". The plan for government integration is also revealed as the report states: "to remain competitive in the global economy, policymakers must devise forward-looking, collaborative policies that integrate governments". Also called for is the adoption of "unified North American regulatory standards".
Features of NAU:
The Trans-Texas Corridor and the NAFTA Superhighway
The NAFTA Superhighway and its entry point at the trans-Texas corridor were first proposed in 2002. It consists of a 1,200 foot wide highway that also carries utilities such as electricity, petroleum and water as well as railway tracks and fiber-optic cables. When completed, the new road will allow containers from the Far East to enter the U.S. through the Mexican port of Lazaro Cardenas, bypassing the Longshoreman's Union. With Mexican drivers and without the involvement of the teamsters union, the Mexican trucks will drive straight into the heart of the US, crossing the border in fast lanes, and checked only by a new electronic system. The first customs stop will be the new Smart Port complex in Kansas City. From there the trucks may disperse into the U.S. or continue northward into Canada, again crossing the border with only an electronic checkpoint.
Millions of acres of land for the completion of this highway will be taken under the new laws of eminent domain.
A government pilot program has allowed Mexican trucking companies to make deliveries anywhere in the U.S. since April 2007, even before the completion of the superhighway. There is no limit on the number of trucks the 100 companies in the pilot program can operate. Eventually all Mexican trucking companies are to be granted the same access. These Mexican drivers are paid substantially less that their U.S. counterparts, their operations are not regulated, and they are driving on U.S. taxpayer subsidized roads.
The Amero
This is the name of what may be the North American Union's counterpart to the euro. It was first proposed by Canadian economist Herbert G. Grubel in his book The Case for the Amero published in 1999, the same year the euro became currency. Robert Pastor supported Grubel's idea in his book Toward A North American Community published in 2001. If implemented, the Amero's debut may come later in the progression of the NAU, with exchange rates that depend on market forces at the time, after the economies of the three countries have been integrated and homogenized.
The North American Plan for Avian and Pandemic Influenza
Finalized and released at the September 2007 summit of the SPP, this plan calls for a "comprehensive coordinated North American approach during outbreaks of influenza." It gives authority to international officials "beyond the health sector to include a coordinated approach to critical infrastructure protection," including "border and transportation issues".
It sets up a "senior level Coordinating Body to facilitate the effective planning and preparedness within North America for a possible outbreak of avian and/or human influenza pandemic under the Security and Prosperity Partnership (SPP)." The SPP is to act as "decision-makers." "The chair of the SPP Coordinating Body will rotate between each national authority on a yearly basis" resulting in foreign decision making for Americans in two out of every three years.
The plan suggests that these powers will include "the use of antivirals and vaccines... social distancing measures, including school closures and the prohibition of community gatherings, isolation and quarantine."
Since its inception in 1921, the Council on Foreign Relations (CFR) has attracted men and women of power and influence. Its stated intentions are to bring about the surrender of the sovereignty of the national independence of the United States. The ultimate, declared aim of the CFR is to create a one-world government, and to make the U.S. a part of it. The stated intentions of the CFR are clearly treasonous to the U.S. Constitution.
The influence of the CFR is wide. Not only does it have members in the U.S. government, but its influence has also spread to other vital areas of American life. Members have run, or are running, NBC and CBS, the New York Times, and The Washington Post, and many other important newspapers. The leaders of Time, Newsweek, Fortune, Business Week, and numerous other publications are CFR members.
The organization's members also dominate the political world. U.S. presidents since Franklin Roosevelt have been CFR members with the exception of Ronald Reagan. The organization's members also dominate
the academic world, top corporations, unions and military. They are on the board of directors of the Federal Reserve.
Hillary Clinton, Barack Obama, John Edwards, Mitt Romney, John McCain, and Rudy Guiliani are all either members of the CFR or have close ties with it. Mike Huckabee is reportedly not a member, but following his interaction with the group in September, he has become a favored candidate in the eyes of the media. Republican Ron Paul is the only remaining significant candidate who does not have ties with the CFR. He has has voiced opposition to the NAU for several years.
Where Do You Stand on This Issue?
There is an ideological battle being waged between the forces supporting globalism and the forces supporting national sovereignty. If you plan to participate in the 2008 presidential election, you will need to answer these questions for yourself: Do you believe in the timelessness of the Constitution, or do you believe that the Constitution has served its usefulness and it's time for another model for government? Are you in favor of international government and more regulation by the United Nations, or do you favor continuation of the institutions that have served the U.S. in the past? Do you want big government with its attendant costs and regulations, or do you favor small government that allows for self direction?
Barbara is a school psychologist, a published author in the area of personal finance, a breast cancer survivor using "alternative" treatments, a born existentialist, and a student of nature and all things natural.
All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing LLC takes sole responsibility for all content. Truth Publishing sells no hard products and earns no money from the recommendation of products. NaturalNews.com is presented for educational and commentary purposes only and should not be construed as professional advice from any licensed practitioner. Truth Publishing assumes no responsibility for the use or misuse of this material. For the full terms of usage of this material, visit www.NaturalNews.com/terms.shtml


The PROTOform P909 currently reigns as the top race body for the Kings of the Sport - the 1/8th Nitro On-Road category. This body offers contemporary styling as well as state-of-the-art aerodynamic features, and was the body of choice for 2011 IFMAR World Champion Robert Pietsch.
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text:
Fossil Fuel Extraction
Fossil fuels are the main energy source used in Barbados. Other sources which are used on a smaller scale are solar energy and to a limited extent bagasse.
Barbados extracts crude oil and natural gas from a total of 96 onshore wells in and around the Woodbourne oilfield in St. Philip. The total production of these wells was 559,675 bbls of crude oil and 1,339,577mcf of natural gas in 2000. By 2001 production had fallen slightly to 463,249 bbls of crude oil and 1,233,729 mcf of natural gas.
This crude oil is no longer refined in Barbados; since the closure of the Mobil Oil Refinery in 1998, domestic crude oil is exported to Trinidad for refining and all refined fuels are now imported.
Energy Tip!
Consider buying a highly fuel-efficient vehicle. A fuel-efficient vehicle, a hybrid vehicle, or an alternative fuel vehicle could save you a lot at the gas pump and help the environment.
ENERLAC Magazine produced by OLADE
Nation Newspaper
Barbados Telecommunications Service Directory
Legal and Regulatory Unit
Research and Planning Unit
Renewable Energy and Energy Conservation Unit
General Info (NRD)
Offshore Programme
Geology of Barbados
Barbados' Accretionary Prism
Stratigraphy of Barbados
History of Hydrocarbon Production in Barbados
Casing Programme
On-shore Barbados Well Location Map
Hydrocarbon Production and Consumption
On-shore Barbados Well Logs


text:
Live Now: CTV Morning Live
laura.brown@bellmedia.ca
CTV News Atlantic Reporter
Laura Brown is a videographer based out of Fredericton.
Laura grew up on the north shore of Prince Edward Island, in the small community of Hamilton. Laura knew as early as grade school that she would like to pursue a career in news, and went on to major in journalism and political science at St. Thomas University. She graduated with distinction in 2012.
She had also completed a military journalism course with the University of Calgary.
Laura began her career reporting briefly for CBC New Brunswick, before moving to Moncton to work as a video journalist with Global News. She has covered some of the toughest stories to hit the Maritimes in recent years, including the deaths of two young boys who were strangled by a python. In October of 2013, Laura covered the contentious anti-shale gas protests in Rexton, N.B. She has earned several awards for her breaking news and videography work.
Laura moved back to Fredericton in 2014, where she covered provincial affairs and the New Brunswick legislature. In January, 2016 she joined the CTV Atlantic team, working out of the Fredericton bureau.
Laura says the power of telling stories through images and video is what drew her to television, and she feels privileged every time a Maritimer trusts her to tell their story.
Laura also enjoys good food, and going home to P.E.I.
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