text:
Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides
Yogesh S. Deshmukh, Carolus H.R.M. Wilsens, René Verhoef, Michael Ryan Hansen, Dmytro Dudenko, Robert Graf, Enno A. Klop, Sanjay Rastogi
The synthesis and structural characterization of various aromatic-aliphatic polyamides are reported in this study. The polymers are obtained by solution polymerization of p-phenylenediamine with various aliphatic diacid chlorides. The resulting polyamides are labeled PA P-X, where X varies between 5 and 10 and corresponds to the number of carbon atoms of the dicarboxylic acid monomers used in the synthesis. The polyamides are obtained with Mn values of 10 kg/mol or higher, as determined by solution NMR spectroscopy and gel permeation chromatography (GPC). The polymers PA P-5 to PA P-8 degrade prior to melting, whereas only PA P-10 shows melting on heating. The structural changes in the polymers, with increasing methylene segments, are investigated by X-ray diffraction and molecular modeling. Conformational changes as a function of temperature have been studied by solid-state NMR spectroscopy. These studies have been illustrative in following the phase transformations in the aromatic-aliphatic polymers. For the crystal packing of the polymer based on the odd acid (PA P-5) a sheetlike structure, similar to that of the aromatic polyamide PPTA, is observed. Despite the presence of the odd spacer, PA P-5 exhibits a hydrogen bonding length very similar to that of PPTA, whereas the intersheet distance increases and the interchain distance decreases. As a result, the crystal structure of PA P-5 is distinctively different from that of the aliphatic polyamides having the same odd diacid, e.g. PA 65. In contrast, the crystal packing of PA P-6 with even diacid is similar to that of the α form of PA 46. The change of the chemical shift of the carbonyl groups with increasing number of methylene units suggests a weakening in the hydrogen bonding with respect to PPTA. For PA P-10 this weakening ultimately translates to melting of the polymer prior to degradation.
https://doi.org/10.1021/acs.macromol.5b01747
10.1021/acs.macromol.5b01747
Dive into the research topics of 'Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides'. Together they form a unique fingerprint.
Polyamide Chemical Engineering 100%
Polymer Chemistry 37%
Hydrogen Bonding Chemistry 25%
Carbene Pharmacology, Toxicology and Pharmaceutical Science 18%
Carbromal Pharmacology, Toxicology and Pharmaceutical Science 18%
Aromatics Engineering 18%
Molecular Modeling Chemistry 12%
Synthesis (Chemical) Chemistry 12%
Deshmukh, Y. S., Wilsens, C. H. R. M., Verhoef, R., Hansen, M. R., Dudenko, D., Graf, R., Klop, E. A., & Rastogi, S. (2016). Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides. Macromolecules, 49(3), 950-962. https://doi.org/10.1021/acs.macromol.5b01747
Deshmukh, Yogesh S. ; Wilsens, Carolus H.R.M. ; Verhoef, René et al. / Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides. In: Macromolecules. 2016 ; Vol. 49, No. 3. pp. 950-962.
@article{4f9f770419cd4dc2847493cf5086920c,
title = "Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides",
abstract = "The synthesis and structural characterization of various aromatic-aliphatic polyamides are reported in this study. The polymers are obtained by solution polymerization of p-phenylenediamine with various aliphatic diacid chlorides. The resulting polyamides are labeled PA P-X, where X varies between 5 and 10 and corresponds to the number of carbon atoms of the dicarboxylic acid monomers used in the synthesis. The polyamides are obtained with Mn values of 10 kg/mol or higher, as determined by solution NMR spectroscopy and gel permeation chromatography (GPC). The polymers PA P-5 to PA P-8 degrade prior to melting, whereas only PA P-10 shows melting on heating. The structural changes in the polymers, with increasing methylene segments, are investigated by X-ray diffraction and molecular modeling. Conformational changes as a function of temperature have been studied by solid-state NMR spectroscopy. These studies have been illustrative in following the phase transformations in the aromatic-aliphatic polymers. For the crystal packing of the polymer based on the odd acid (PA P-5) a sheetlike structure, similar to that of the aromatic polyamide PPTA, is observed. Despite the presence of the odd spacer, PA P-5 exhibits a hydrogen bonding length very similar to that of PPTA, whereas the intersheet distance increases and the interchain distance decreases. As a result, the crystal structure of PA P-5 is distinctively different from that of the aliphatic polyamides having the same odd diacid, e.g. PA 65. In contrast, the crystal packing of PA P-6 with even diacid is similar to that of the α form of PA 46. The change of the chemical shift of the carbonyl groups with increasing number of methylene units suggests a weakening in the hydrogen bonding with respect to PPTA. For PA P-10 this weakening ultimately translates to melting of the polymer prior to degradation.",
author = "Deshmukh, {Yogesh S.} and Wilsens, {Carolus H.R.M.} and Ren{\'e} Verhoef and Hansen, {Michael Ryan} and Dmytro Dudenko and Robert Graf and Klop, {Enno A.} and Sanjay Rastogi",
doi = "10.1021/acs.macromol.5b01747",
journal = "Macromolecules",
Deshmukh, YS, Wilsens, CHRM, Verhoef, R, Hansen, MR, Dudenko, D, Graf, R, Klop, EA & Rastogi, S 2016, 'Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides', Macromolecules, vol. 49, no. 3, pp. 950-962. https://doi.org/10.1021/acs.macromol.5b01747
Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides. / Deshmukh, Yogesh S.; Wilsens, Carolus H.R.M.; Verhoef, René et al.
In: Macromolecules, Vol. 49, No. 3, 09.02.2016, p. 950-962.
T1 - Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides
AU - Deshmukh, Yogesh S.
AU - Wilsens, Carolus H.R.M.
AU - Verhoef, René
AU - Hansen, Michael Ryan
AU - Dudenko, Dmytro
AU - Graf, Robert
AU - Klop, Enno A.
AU - Rastogi, Sanjay
N2 - The synthesis and structural characterization of various aromatic-aliphatic polyamides are reported in this study. The polymers are obtained by solution polymerization of p-phenylenediamine with various aliphatic diacid chlorides. The resulting polyamides are labeled PA P-X, where X varies between 5 and 10 and corresponds to the number of carbon atoms of the dicarboxylic acid monomers used in the synthesis. The polyamides are obtained with Mn values of 10 kg/mol or higher, as determined by solution NMR spectroscopy and gel permeation chromatography (GPC). The polymers PA P-5 to PA P-8 degrade prior to melting, whereas only PA P-10 shows melting on heating. The structural changes in the polymers, with increasing methylene segments, are investigated by X-ray diffraction and molecular modeling. Conformational changes as a function of temperature have been studied by solid-state NMR spectroscopy. These studies have been illustrative in following the phase transformations in the aromatic-aliphatic polymers. For the crystal packing of the polymer based on the odd acid (PA P-5) a sheetlike structure, similar to that of the aromatic polyamide PPTA, is observed. Despite the presence of the odd spacer, PA P-5 exhibits a hydrogen bonding length very similar to that of PPTA, whereas the intersheet distance increases and the interchain distance decreases. As a result, the crystal structure of PA P-5 is distinctively different from that of the aliphatic polyamides having the same odd diacid, e.g. PA 65. In contrast, the crystal packing of PA P-6 with even diacid is similar to that of the α form of PA 46. The change of the chemical shift of the carbonyl groups with increasing number of methylene units suggests a weakening in the hydrogen bonding with respect to PPTA. For PA P-10 this weakening ultimately translates to melting of the polymer prior to degradation.
AB - The synthesis and structural characterization of various aromatic-aliphatic polyamides are reported in this study. The polymers are obtained by solution polymerization of p-phenylenediamine with various aliphatic diacid chlorides. The resulting polyamides are labeled PA P-X, where X varies between 5 and 10 and corresponds to the number of carbon atoms of the dicarboxylic acid monomers used in the synthesis. The polyamides are obtained with Mn values of 10 kg/mol or higher, as determined by solution NMR spectroscopy and gel permeation chromatography (GPC). The polymers PA P-5 to PA P-8 degrade prior to melting, whereas only PA P-10 shows melting on heating. The structural changes in the polymers, with increasing methylene segments, are investigated by X-ray diffraction and molecular modeling. Conformational changes as a function of temperature have been studied by solid-state NMR spectroscopy. These studies have been illustrative in following the phase transformations in the aromatic-aliphatic polymers. For the crystal packing of the polymer based on the odd acid (PA P-5) a sheetlike structure, similar to that of the aromatic polyamide PPTA, is observed. Despite the presence of the odd spacer, PA P-5 exhibits a hydrogen bonding length very similar to that of PPTA, whereas the intersheet distance increases and the interchain distance decreases. As a result, the crystal structure of PA P-5 is distinctively different from that of the aliphatic polyamides having the same odd diacid, e.g. PA 65. In contrast, the crystal packing of PA P-6 with even diacid is similar to that of the α form of PA 46. The change of the chemical shift of the carbonyl groups with increasing number of methylene units suggests a weakening in the hydrogen bonding with respect to PPTA. For PA P-10 this weakening ultimately translates to melting of the polymer prior to degradation.
UR - https://pubs.acs.org/doi/10.1021/acs.macromol.5b01747
U2 - 10.1021/acs.macromol.5b01747
DO - 10.1021/acs.macromol.5b01747
JO - Macromolecules
JF - Macromolecules
Deshmukh YS, Wilsens CHRM, Verhoef R, Hansen MR, Dudenko D, Graf R et al. Conformational and Structural Changes with Increasing Methylene Segment Length in Aromatic-Aliphatic Polyamides. Macromolecules. 2016 Feb 9;49(3):950-962. doi: 10.1021/acs.macromol.5b01747


I'm not sure there is a better way to communicate your fit for the position than to address how your career experience and expertise meet the needs of the organization. Think about what their needs might be, and then make the connection between your experience and how you can meet their needs. This will cause the employer to have confidence that you're a great candidate.
It's important to be purposeful and strategic in how you write—and structure—your resume. Resume writers don't just throw words onto a piece of paper in any random order and then simply hope something sticks. No, there's a reason why they place certain information on your resume—and maybe even more importantly is WHERE they place that information. The most relevant information should come first. It should be at the top of your resume, and should be the first bullet point under each section.
Save the recruiter or hiring manager time by not making them go searching for what they need. They'll be looking for job titles, dates of employment, and major accomplishments. They'll also be looking for important keywords to ensure you have the required skills for the position. Put this information at the top of the resume, and make job titles and employment dates easy to find. This helps them to more quickly and easily go through their mental checklist during that initial six-second resume scan so they can then decide to read your resume further.
Once you've passed the initial six-second scan, the hiring manager will want to go back and give your resume a more thorough reading to ensure you have the necessary skills and experience for the position. This is where details are critical. Expound further on your experience, contributions, and accomplishments. Use facts and figures to sell the value you can offer the employer and to get their attention.
5. If You've Seen It Elsewhere – RUN!


Collins: "We Need To Improve Winning Mentality"
First team coach believes Crewe have to learn how to see games through.
James Collins says Crewe Alexandra have to rediscover that winning mentality after letting a 1-0 lead slip at Altrincham and then seeing us go down 1-0 to Hednesford Town the following night.
The Alex first team coach appreciates that pre-season games are mostly about getting match fitness and sharpness but he was disappointed with the goals we have conceded this week. Crewe conceded from a set-piece free-kick against Altrincham and were then punished by a defensive mistake the following evening at Hednesford.
James told crewealex.net: "They have all been positive work-outs in pre-season and a good learning curve for the younger ones. It is all about being ready for the season but of course, you want to win every game.
"We were winning 1-0 at Altrincham and had worked hard for that lead. We have then conceded from a soft free-kick. It was a terrific delivery from the lad but we have lost him at the far post, so from going 1-0 up and looking comfortable, we ended up drawing the game.


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There Goes Another Candidate: Care of the Dog That Bit You Edition
A few testy gallons of ink have been spilled over the past few days over what was supposed to be a small, character-building anecdote during a Boston Globe profile of Mitt Romney. Not since Lyndon Johnson drop-kicked an innocent bloodhound into the Mekong has the mistreatment of a canine caused such a political stir.
Romney, sometime Massachusetts governor and Presidential contender, was asked for an example of his crisis management style. Instead of saying something along the lines of "I helped a troubled Salt Lake City Olympics committee overcome scandal" or "I ushered through a large-scale engineering project in my state through a fiscal crisis," he decided that the best course of action was to retell a delightful tale about how, during a family vacation to Canada in the early 1980's, he strapped the family's Irish Setter to the top of the car. Then, when the animal unexpectedly got nervous about traveling atop a large metal canister at 55 mph in a small plasticish cage and responded by leaking brown disgustingness all over the back window, Elder Statesmen and Future President Mitt Romney pulled over, took a garden hose, sprayed off the dog, car, and cage, replaced the poor mutt back in his canister, and all individuals went upon the remainder of their trip, presumably canine-diarrhea-free.
Not all that surprisingly, animal rights activists and, well, most human beings reacted with a range of emotions going from "general head-shaking" to "comparing it to the Holocaust." Also, not surprisingly, many of the other presidential contenders were asked about their own relationships with pets. Perhaps remarkably, many of the other candidates have no compunctions about detailing their stories, and subsequently a lot of skeletons were drug out, dusted off, and put proudly on display.
Before he lost nearly 110 pounds, Mike Huckabee kept a steady supply of rats in his Little Rock governor's mansion to guarantee a fresh supply of milk for his daily breakfast of twenty-four pancakes, eighteen sausage links, and a colonic.
John Edwards bravely saved a warren of rabbits from being subjected to cruel cosmetic trials by volunteering himself instead.
When house training a beagle, Rudy Giuliani used a then-untested method of corrective conditioning, mostly rewarding the dog with corned beef hash when he was good, and shoving a broom handle repeatedly up its anus when he was bad. Then came 9/11.
While interred in a POW camp in Vietnam, Arizona senator John McCain had to eat a greyhound to keep himself from starving. In his defense, it was #4, no MSG, on the menu.
Bill Richardson owns a Chihuahua, which currently is the only evidence available that he is actually of Hispanic origin.
Hillary Clinton distrusted husband Bill's dog, Buddy, as a diversion in attention to their marriage. She arranged the White House Travel Office, the Rose Law Firm, and Susan McDougal to have Buddy hit by a car to combat the ever-growing threat of the vast right-wing conspiracy.
On the very day that he descended from the heavens, Barack Obama healed two groundhogs, four dogs, and a leprous tabby.
Fred Thompson used to be responsible for taking Annie Parisse out for her daily walk on the set of Law & Order.
On his regular trips to Fantastica, Dennis Kucinich rides atop a snow white unicorn accompanied by a band of musical changelings.
Wesley Clark has keeps a stable full of stalking horses, which are owned by the Clintons.
Ron Paul regularly establishes cockfight rings, proclaiming it to be an educational display of the concept of "survival of the fittest."
Joe Biden keeps a parrot. Big surprise.
Every fortnight for the past thirty years, Newt Gingrich holds a ritual deep in the woods of Arlington where a half dozen virgin white mishas are sacrificed to Alvin Toffler.
Dick Cheney often drinks the blood of fawns for lunch, usually mixed with a quart of Valvoline.
While on a promotional tour for An Inconvenient Truth in Antarctica, Al Gore married a puffin in a moment of ecologically orgasmic weakness. The marriage was later annulled on advice from his advisor.
Sam Brownback refuses to believe that calico cats exist.
While some may dismiss all of this as unimportant distractions from the real issues, it's not exactly a secret that character counts during elections. People want to know the human side of a candidate and, in the case of Rudy Giuliani, whether there is actually at least a human side. People voted for George W. Bush not because of his stance on the estate tax or abortion, but because he seemed like a regular guy that would not be out of place sitting in your living room, watching the football game, and not being able to figure out the proper way to swallow a pretzel without passing out. Bill Clinton's ability to feel our pain wasn't just a throwaway political cliché, but a genuine ability to build rapport with people by making everyone in the room feel like he was looking them right in the eye, pressing firmly on their hand in a comforting manner and slowly moving his hand up the small of your back looking for the clasp.
Though when it comes down to it, perhaps Romney's so-called gaffe was a well-placed advantage to his campaign. By declaring the experience he has with hosing down feces, psychological manipulation, and emotionless crisis management, he's establishing himself as the person best able to handle Gitmo.
This entry was posted on Sunday, July 1st, 2007 at 4:21 pm and is filed under Animals, Politics, TGAC.	You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

redpajama_set_name: RedPajamaCommonCrawl


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Freaky Friday: "Treat Your Mother Right"
Cory Casciato
| Commentary |
Cory Casciato | August 28, 2009 | 11:10am
Part life lesson, part novelty rap and all awesome, this entry into the canon of freak comes from '80s icon Mr. T. It's hard to believe now, in the cold hard light of not-the-'80s, but for whatever reason Mr. T was quite the phenomenon back in the day. He was the breakout star of the A-Team, easily one of the most ridiculous shows ever put on the air. That resulted in the man getting a cartoon show, a breakfast cereal and the odd little nugget of insanity like this clip. While you're watching it, you may find cause to ask yourself, "How did this ever come to be? What the fuck was wrong with the '80s? And where can I get a pair of short-shorts like that?" I can't answer these questions -- no one can -- but luckily, I don't have to: the video speaks for itself.
Cory Casciato is a Denver-based writer with a passion for the geeky, from old science fiction movies to brand-new video games.
Facebook: Cory Casciato
Twitter: @casciato
Many Mountains Canceled a Tour; Going Home Was a Strange Trip
Dog House Music Studios Plans to Pay Bands to Livestream Concerts
Adiel Mitchell's "Want It Now" Is Pure R&B-Pop Pleasure
You Have Until 2 p.m. to Bid in the El Chapultepec Auction


5000 Years of Tiles is the essential, single - volume colour compendium of tile art and production around the world, from ancient times to the present day. Over 350 beautiful colour illustrations showcase an incredible range of tile arts, including the first fired roof tiles i n ancient Greece in the third millennium BC, English medieval floor pavements from Clarendon Palace, figural tiles from China, richly patterned Iznik tiles from the Islamic world and stylized ceramic tiles of the Arts and Crafts movement. Placing the tiles firmly in their historical and cultural context, this richly illustrated book highlights the continuity and diversity of tiles , examining how tile art in one time and place has inspired and rejuvenated those in others. The function and form of this versat ile art is examined in stunning detail, from floors to roofs, stoves to bathrooms, cathedrals to metro stations to reveal a fascinating history of design, colour and decoration .


Modern furniture is future to take up space in an ingenious and customizable way. imaginative storage capability and a lack of heavy, nonfunctional facts are an important feature of forward-looking furniture design. One of the more good-looking aspects of modern wooden furniture is a use of more natural finishes and lighter colored gear. customary furniture was known for deeper, more soaked colors while modern furniture should come into view light, easy and well-ventilated. The use of these less uneven coloring, shiny finish and wood choices allow for its simple design to be painted and give to its ability to be with no trouble added to a room.


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HomeBoxing
BoxingOlympics
RIO OLYMPICS: Muhammed Ali Loses Boxing Bout On Debut
Britain's flyweight boxer, Muhammed Ali was defeated in his Rio debut on Monday.
The young Ali – reportedly bestowed the name by his boxing-mad father – was left distraught and in tears after his Olympic dream came to a premature end after just nine minutes of action.
Venezuela's Yoel Finol, 19, was awarded the bout on a unanimous points decision to leave Ali, who is a year older, with his head in his hands and looking stunned.
"I've been here too long and I was itching to get in there," said Ali, who was making his first appearance nine days after the Rio boxing began.
Tokyo Olympics: Blessing Oborududu wins Nigeria's first ever wrestling medal
"I let the emotions get the better of me, I just tried too hard and nothing was flowing and now I am just here…" said Ali, his voice trembling and tears welling in his eyes.
"I just feel like it's the end of the world."
The heavyweight legend Ali, who died in June aged 74, announced his presence to the world — he was then called Cassius Clay — with gold at the Rome Olympics in 1960.
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Tom Petty (9)
Tom Petty & Heartbreakers (5)
Tom Petty & the Heartbreakers (3)
Warner Records (8)
Geffen Records (6)
Reprise / WEA (2)
MCA (1)
180 gram (7)
Deluxe Editions (3)
Items 0 - 0 of 17
Angel Dream (Songs From The Motion Picture She's The One)
To celebrate the 25th anniversary of the release of Shes The One, we are releasing a remixed, remastered and re-imagined version of this album. The original album included several songs that were... more
Finding Wildflowers (Alternate Versions)(2 LP)
In order to get these tracks before, one would've had to have sprung for the limited-edition super-deluxe 9-LP version of "Wildflowers & All the Rest" (2020). Rick Rubin produced "Wildflowers,"... more
Wildflowers & All The Rest
Petty's Top 10, triple-platinum seller from '94, produced by Rick Rubin, "Wildflowers," returns on 2 CDs or triple vinyl in remastered form, expanded via "All the Rest": the 10 songs recorded during... more
The Best Of Everything - The Definitive Career Spanning Hits Collectio n
Tom Petty & Heartbreakers
Limited four 180gm vinyl LP pressing. This collection of personal favorites and important milestones is the first anthology to span Petty's entire career, from the first album to Mudcrutch 2. The... more
An American Treasure
Petty's widow Dana and daughter Adria found so much unreleased material in Tom's archive after he passed away that these two new anthologies became inevitable. Fans will be so thankful for this... more
Damn The Torpedoes
Limited 180gm vinyl LP pressing. Damn The Torpedoes is the RIAA triple platinum-certified third album by Tom Petty and the Heartbreakers. It was released to critical acclaim in 1979, and was a... more
Limited 180gm vinyl LP pressing. Into the Great Wide Open is the eighth studio album by American rock band Tom Petty and the Heartbreakers, first released in 1991. The album was the band's last with... more
Reaching #3, this 1989 LP was Petty's second biggest chart success ever. This album simply couldn't miss, as Tom came up with a fantastic set of songs here, aided and abetted by none other than Jeff... more
Long After Dark
Limited 180gm vinyl LP pressing. Long After Dark is the fifth album from Tom Petty and The Heartbreakers. It was released in November 1982, reached #9 on the Billboard 200, and was produced by Jimmy... more
Highway Companion
Jeff Lynne collaborated with Petty on this 2006 recording, which plays like a road trip across 2 LPs. Lynne's production and Petty's evocative songs combined to send this all the way to #4: "Saving... more
Petty poured emotion into this 1999 double album in the wake of his devastating divorce. Fans connected deeply with Petty's first LP with the Heartbreakers in eight years, sending the album to the... more
The Studio Album Vinyl Collection 1976-1991
Release Date: 12/9/2016
When Tom Petty and the Heartbreakers first burst onto the national charts with their debut album, released while the music world was in the throes of the punk revolution, one thing was clear: this... more
What do you get when you bring together all the crucial hits ('70s, '80s, early '90s) from the fabulously successful career of Tom Petty? You get his biggest album of all time, the 1993 "best-of"... more
Fifty million record sales ago, Petty & his Heartbreakers shouted their arrival from the rooftops with this 1976 LP. If this isn't one of the world's most outstanding rock debuts, we don't know what... more
Youre Gonna Get It
A big step toward stardom, this 1978 LP saw Tom and the band vault to #23 pop thanks to a killer set of songs including their early hits "I Need to Know" and "Listen to Her Heart." You'll find those... more
Live Anthology
Genre: Rock, Box Sets
The mother of all live Petty comps! Covering 1978–2007, this 51-track set (48 on the CDs) is culled from hundreds of hours of live recordings covering every era of Petty and the Heartbreakers on... more


Best Of Grand Piano Wall Shelf. grand piano shelf find great deals on ebay for grand piano shelf shop with confidence 23 best piano ideas images on pinterest grand piano shelf with sheet music pasted to the back find this pin and more on piano ideas by sarah ritter a converted shell from a baby grand piano with keyboard to an extraordinary wall shelf . These are prepared for download, if you like and want to get it, simply click save badge in the web page, and it will be instantly downloaded in your pc. For many updates and recent information about Best Of Grand Piano Wall Shelf pictures, please share to google plus or follow us on tweets, Instagram and path, or you mark this page on book mark section, We attempt to present you update regularly with fresh and new pics, love your surfing, and find the perfect for you. Don't forget for send this pics to Google Plus, Facebook, Twitter, Instagram or Pinterest. Thank you.


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McFarlane DC Multiverse The Drowned, Teen Titans Robin, Red Son Superman and Death Metal Batman
A new batch of McFarlane DC Multiverse figures has gone up for pre-order ready for a February 2021 release date.
The wave had been announced previously and features four figures from across the DC Multiverse. The Drowned, Bryce Wayne of Earth -11 is taken from the comicbook of the same name. She will come armed with her Trident.
The Damian Wayne Robin is taken from Teen Titans and will feature Robin with a sword and shuriken weaponry.
The Dark Knight : Death Metal Batman is designed to accompany the Bone BatCycle. He will feature a Scythe accessory and his cape will be split to allow him to sit on the bike.
The final figure is a rare departure from Batman and gives us the Red Son Superman from the comic book of the same name. Superman will come with a flight stand accessory and alternative hands.
All the figures will include a collectible art card and display stand as usual.
Bryce Wayne of Earth -11 harbored a deep hatred of the Atlanteans for their role in the death of her beloved, Sylvester Kyle. In a quest to avenge Kyle, she spliced her DNA with that of an Atlantean, becoming a super-powered Dark Knight called The Drowned capable of breathing and fighting underwater.
Incredibly detailed 7" scale figures based off the DC Multiverse
Designed with Ultra Articulation with up to 22 moving parts for full range of posing and play
Each figure comes with a base and with various character specific accessories
Batman Earth -11 figure is based on the Comic Batman: The Drowned #1 (2017)
Batman Earth -11 comes with The Drowned Trident and base
Included collectable art card with Batman: The Drowned #1 artwork on the front, and character biography on the back
Robin is Batman's protégé and crime-fighting partner. More than just a sidekick, Robin is an accomplished acrobat, a skilled fighter, and a sharp detective in his own right. Through rigorous and constant training, Robin maintains his physical edge, which, along with his knowledge of martial arts, makes him a formidable match for even the most experienced criminals. Although he does not possess any super powers, his discipline, training, and intelligence make him the natural leader of the Teen Titans!
Damian Wayne as Robin figure is based on the comic book Teen Titans #20 (Comics 2018)
Damian comes with a Batagrang throwing star, sword, and a base
Included collectable art card with Teen Titans #20 artwork on the front, and character biography on the back
Following the universe-shattering events of Dark Nights: Metal, the Earth is enveloped by the Dark Multiverse and has transformed into a hellish landscape twisted beyond recognition. Willing to sacrifice his own humanity for the greater good, Batman wields an evil Black Lantern power ring, which grants him the power to resurrect the dead. Now, leading an army of zombies and riding a Batcycle made of bones, the Dark Knight wages war against The Batman Who Laughs and his omnipotent goddess, Perpetua, in his mission to save the DC Multiverse!
Batman is based on the comic book Dark Nights: Death Metal #1 (Comics 2020)
Batman comes with a Bat Sickle and base
Includes collectable art card with Batman Dark Nights: Death Metal artwork on front and character biography on the back
In an alternate reality, the rocket ship carrying the infant who would later be known as Superman landed in the midst of the 1950s Soviet Union, rather than Smallville, Kansas. Raised on a collective farm, the last survivor of Krypton grew up and now uses his incredible superpowers as a hero to the Soviet people, fighting a never-ending battle for Stalin and changing the world drastically from what we know.
Superman comes with alternate hands and flight stand
Superman Red Son figure is based on the Collected Book Superman: Red Son (New Edition) (2014)
Included collectable art card with Superman: Red Son artwork on the front, and character biography on the back


Computer Programming Insurance California. As an IT expert and computer programmer, you face the same risks (and different ones) that every other business faces. This applies in particular if you provide consulting services, for instance, Levi Strauss Company, the jean maker took legal action against Deloitte IT consulting firm after the software designed to control payrolls and inventory failed. The Deloitte IT Company was in turn forced to pay damages amounting to $100 million.
With so many companies depending on computer systems to run operations efficiently, you could be the target of lawsuits if your services do not meet client expectations. Due to the nature of your profession, it is best to get a computer programming insurance California policy that will help you in offsetting your personal risks and protect your firm.
Computer programming insurance California protects your firm from lawsuits with rates as low as $27/mo. Get a fast quote and your certificate of insurance now.
Computer programming insurance California is a type of commercial coverage that is specially meant to deal with the unique risks that are connected to professional IT careers and computer programmers. Irrespective of whether you own your own IT business or work as a freelance IT expert it is important for you to safeguard your business from the risks of the trade. To ensure you are getting the proper CA computer programmer coverage you will need to assess the risks that you are likely to face in your line of work.
General Liability and Property Insurance: Just as any other business you need a computer programming insurance California policy for your physical assets such as supplies and equipment as well as coverage for client and customer injuries due to negligence or accidents. Injuries and negligence often result in medical lawsuits that could be expensive for your company.
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Computer programming insurance California may seem like an unaffordable or unnecessary overhead that stresses an already tight budget. As a result, if you decide to buy an insurance policy you might be tempted to save money by selecting a higher deductible which is the amount of money you pay out before accruing benefits. But it's important to keep in mind that you should not choose a deductible that is higher than what you can afford comfortably. If you cannot meet the expense of your deductibles, your coverage does not exist in the sense you will be outof pocket for a large amount and that defeats the purpose of the insurance..
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text:
You don't need a lottery to do your duty
The New Sunday Times - 02/25/2007
IT had all the ingredients of a colourful fireworks display that could have kept the nation entertained for a long time.
But this was not the case, when the "MyKad lucky draw" — Jom Tukar dan Menang — became a non-event.
To some it was an anti-climax, given how the report was initially framed.
Although the issue was played up when one menteri besar joined in the fray and chose to rap the Home Affairs Minister for making the allegedly "silly and rubbish" remark, fortunately it fizzled off quickly.
The person directly implicated, the former Home Affairs Minister, was bold enough to come forward to clear the air and took a sharply different stance.
This is not about the merit or otherwise of the lucky draw, rather it is about how a potentially explosive issue can be defused with humility and moral courage.
It is about prioritising what issues need more urgent attention. For too long, the "who's dun it" plot has been given prominence, with finger-pointing and blame-assigning becoming a knee-jerk response.
More so when they are controversial issues involving various parties or personalities.
So when the current Natural Resources and Environment Minister categorically refused to be dragged into the battle of wits surrounding the contest, it was a breath of fresh air.
As it happened, he gracefully accepted the cancellation and admitted that it was the prerogative of the current minister to make such a decision.
He was quoted as saying, "If that is his decision, I have no objection", without the use of any provocative superlatives.
Perhaps, after taking on the new portfolio, the former Home Affairs Minister is by now "wiser" that the turbulence over the lucky draw issue is no more than one in a teacup. And like all natural turbulence, the sooner one puts it to rest the better.
It saves a lot of time, cost and an unnecessary emotionally-charged situation, which is by and large unproductive.
Moreover, it has been remarked that ministers have many other important things to do.
One of those important things that all ministers must take heed is the recent alarming studies showing that global warming is in fact "real"; and that in the near future, Malaysians may experience a temperature rise between 0.5° Celsius and 4.5° Celsius.
With such a real possibility, we do not need more hot air, practically and figuratively speaking!
While this could be a new learning experience for those faced with unwarranted controversies, for the rest of us the lesson to take home is that we need to be more responsible in carrying out our duties as citizens.
Should each and every one of us discharge our rightful roles as good citizens, there is no reason why any similar controversy would surface at all.
Unfortunately, there is ample evidence to the contrary.
Like the Pavlov experiment, we seem to have been conditioned to "salivate" at everything when a carrot (in this case, a MyVi) is dangled in front of us.
The over-exploitation of this technique has given rise to a number of illegal scams involving victims, ranging from ordinary people on the streets, to executives and professionals.
All are lured by the promise of "fabulous" prizes that are promised by the unscrupulous organisers and agents.
All it takes is to scratch a card, pick a concealed envelope or merely respond to an SMS or an unsolicited "letter of offer".
So it is not surprising when we hear from the Domestic Trade and Consumer Affairs Ministry's Consumer Claims Tribunal that thousands have been duped.
The tribunal is an independent body established under the Consumer Protection Act 1999 with the primary function of hearing and determining claims lodged by consumers.
It is meant as an alternative channel for consumers to seek redress in a faster and cheaper way.
Such crimes resulted in huge losses amounting to tens of millions of ringgit last year, despite the widespread publicity about how these scams are run.
If only we can be more cautious and less gullible, we can avoid many controversies and prevent being victims of scams.
But as for now, this is not to be. Indeed, now there is yet another controversy.
This time, it was triggered by a sexist comment which was later claimed to be "joke aje!" But like always, it was a little too late.
Looking ahead, to prevent future similar occurrences, it may be worth considering a "chastity belt-like gadget" to be fitted on such potential loose cannons! Oops! Joke aje!


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When you stay at Plovers Cove Cottage in Wasaga Beach, you'll be near the beach, within a 5-minute drive of Tower Island and Nancy Island Historic Site. Free self parking is available onsite.


text:
Home 300 Christian Street
Construction Progresses at 300 Christian Street in Queen Village, South Philadelphia
Rendering of 300 Christian Street. Credit: Ambit Architecture.
By: Colin LeStourgeon 8:00 am on April 6, 2022
Foundation work is making significant headway at 300 Christian Street, the site of a new multi-family development in Queen Village, South Philadelphia. Designed by Ambit Architecture, the new building will rise three stories tall and hold 30 residential units, as well as underground parking for 11 cars and 14 bicycles. A roof deck will be located at the top of the building, offering amenity space for residents.
The new building will feature a very attractive exterior that will be a great addition for the site once completed. Ambit nicely deployed brick on the majority of the facade, rising all three floors. Industrial windows will interrupt the brick, some of which will be situated on boxed bay windows clad in black trim. At the northeastern corner of the property, the building will have a striking abutting brick piet which will rise slightly higher than the rest of the building, before traveling horizontally and connecting with the top of the brick portion of the building, which also rises slightly higher than the building's roofline. This will create a stylish effect by forming a small gap between the building and the brick.
The building's street presence is another reason to look forward to its completion. In renderings, street trees are shown planted around the building's footprint, as well as planters in some locations. The combination of brick, window, and black trim also makes for a welcoming sidewalk environment that will be nice to have at this location upon completion. A singular curb cut will be created for the building's parking garage, however, which is somewhat unfortunate.
300 Christian Street. Credit: Google.
The new building will be replacing a vacant lot that has persisted at the location for quite some time. A variety of developments have been planned for the site and have fallen through, leaving the property sitting idle in the meantime, awaiting construction. The site sits at the northeastern section of a Philadelphia Housing Authority development that has had wiped out almost every pre-existing structure on the blocks it sits on. This gives the area touching the housing develop a much different feel from the rest of Queen Village, although seeing natural infill such as this development is something that will continue to change the atmosphere without displacing any existing residents.
300 Christian Street. Credit: Robert Austin Huber.
A YIMBY reader recently reached out with updated photos of the site, revealing lots of progress. While renderings for the project first came out for the project just under a year ago, developers have been moving forward very quickly, with active process now being made on site.
The site was (obviously) cleared, and excavation work moved forward soon thereafter, digging out space for concrete foundations to be poured. Now, that stage of construction has wrapped up, with lots of foundations now visible on site and the footprint of the building slowly coming into scale.
Some progress still remains to be made in terms of foundation work, although the bundling should soon be ready for its vertical rise. Once this happens, things should start coming together quickly.
The new building will be a great improvement for the site, removing an underused property and replacing it with an attractive new multi-family development. The facade takes cues from existing neighborhood architecture and will fit in well with its surroundings, although some features of the design will certainly allow for it to stand out from the street.
No completion date is known for the project at this time, though construction may be finished by early 2023.
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300 Christian Street Ambit Architecture Queen Village South Philadelphia
6 Comments on "Construction Progresses at 300 Christian Street in Queen Village, South Philadelphia"
Joe | April 6, 2022 at 9:11 am | Reply
This building should at least be one story taller. It makes no sense to me why the neighboring houses are four stories and this is only three.
JP | April 6, 2022 at 11:13 am | Reply
One? Try five stories taller.
Related to this site, because it's visible in the pictures, the city needs to adopt a new, dense, mixed-use strategy for PHA properties. That Southwark Homes site is 16.7 acres and it holds a tiny fraction of the number of units it should. There is no reason that they can't build a mix of affordable and market-rate housing there, with some ground-floor retail.
Mayor Kenny | April 6, 2022 at 1:55 pm | Reply
Let me guess your new to Philly and don't remember the towers.
JP | April 6, 2022 at 4:47 pm | Reply
I know that the towers used to be there. The Southwark Homes was an overcorrection.
world b. free | April 8, 2022 at 9:45 am | Reply
You're absolutely right. Those little suburban-style houses are hideous, destroy the flow of the urban environment, and are a complete waste of space. A total overcorrection from the old towers.
Permits Issued for 1709 Snyder Avenue in West Passyunk, South Philadelphia
Construction Underway at 1810 Federal Street in Point Breeze, South Philadelphia
Permits Issued for 608 South American Street in Queen Village, South Philadelphia
Construction Complete at 1507 Christian Street in Graduate Hospital, South Philadelphia


text:
L'histone H1 est l'une des cinq principales protéines histone qui forment la chromatine chez les cellules eucaryotes.  Bien que hautement conservée , il s'agit néanmoins de l'histone présentant la plus haute variabilité de séquence inter-espèces.

Structure

Chez les métazoaires, les protéines H1 présentent un domaine d'"hélice ailée" globulaire central et de longues queues C et N-terminales.  H1 est impliquée dans le regroupement des sous-structures dites en "collier de perles" en une structure de niveau supérieur, dont les détails n'ont pas encore été résolus.  Les histones H1 présentes chez les protistes et les bactéries sont dépourvues du domaine central et de la queue N-terminale.

Fonction
Contrairement aux autres histones, H1 ne constitue pas la particule nucléosomale. Elle repose sur la structure nucléosomale, en maintenant en place l'ADN enroulé autour du nucléosome.  Contrairement aux autres histones représentées par deux molécules par type d'histone par nucléosome, il n'y a qu'une molécule H1 par nucléosome. Au-delà de sa liaison au nucléosome, la protéine H1 se lie à l'ADN de liaison (ou encore ADN linker, d'environ 20 à 80 nucléotides de long) entre les nucléosomes, aidant ainsi à stabiliser la fibre chromatinienne de 30 nm.  La plupart des connaissances sur H1 découle d'études sur des fibres de chromatine purifiées.  L'extraction ionique d'histones de liaison à partir de chromatine native ou reconstituée favorise son dépliement de fibres de 30 nm de longueur vers une conformation nucléosomale en collier de perles dans des conditions hypotoniques.

Il n'est pas certain qu'H1 favorise la formation d'une fibre chromatinienne en forme de solénoïde, dans laquelle l'ADN de liaison exposé est raccourci, ou si elle favorise simplement un changement de l'angle des nucléosomes adjacents, sans affecter la longueur de l'ADN linker. Cependant, il fut montré que les histones linker favorisent la compaction des fibres de chromatine reconstituées in vitro à l'aide d'ensembles d'ADNs synthétiques reconstituant l'élément de positionnement nucléosomal fort «601».  Les expériences de digestion par nucléase et de détections d'empreintes génomique suggèrent que le domaine globulaire de l'histone H1 est localisé près de la dyade du nucléosome, où il protège environ 15 à 30 paires de bases d'ADN additionnel.  De plus, des expériences sur la chromatine reconstituée ont révélé un motif caractéristique dans la dyade en présence de H1.  Malgré des lacunes dans la compréhension du rôle d'H1, un modèle général est apparu selon lequel le domaine globulaire de H1 ferme le nucléosome en liant l'ADN entrant et sortant, tandis que la queue se lie à l'ADN de liaison et neutralise sa charge négative.

De nombreuses expériences portant sur la fonction d'H1 ont été réalisées sur de la chromatine traitée et purifiée dans des conditions de faible teneur en sel, mais le rôle d'H1 in vivo est moins certain.  Des études cellulaires ont montré que la surexpression d'H1 peut provoquer une morphologie nucléaire et une structure chromatinienne aberrantes, et qu'H1 peut servir à la fois de régulateur positif et négatif de la transcription, en fonction des gènes.  Dans les extraits d'œufs de Xenopus , l'appauvrissement en histones linker provoque une extension longitudinale d'environ 2 fois des chromosomes mitotiques, tandis qu'une surexpression provoque une hypercompaction des chromosomes en une masse inséparable.  L'inactivation complète d'H1 in vivo n'a pas été atteinte chez les organismes multicellulaires en raison de la présence de multiples isoformes pouvant être présentes dans plusieurs clusters de gènes, mais diverses isoformes de l'histone de liaison ont été déplétés à divers degrés chez Tetrahymena, C. elegans, Arabidopsis, la mouche et la souris, entraînant divers défauts organisme-spécifiques dans la morphologie nucléaire, la structure de la chromatine, la méthylation de l'ADN et / ou l'expression de gènes spécifiques.

Dynamique
Alors que la plupart des histones H1 du noyau sont liées à la chromatine, les molécules H1 effectuent une navette entre les régions de la chromatine à une vitesse assez élevée.

Il est difficile de comprendre en quoi une protéine si dynamique pourrait être un composant structurel de la chromatine, mais il a été suggéré qu'à l'équilibre nucléaire, l'association entre H1 et la chromatine est encore fortement favorisée, ce qui signifie que malgré sa dynamique, la grande majorité d'H1 à tout moment donné est liée à la chromatine.  H1 compacte et stabilise l'ADN soumis à des forces et pendant l'assemblage de la chromatine, ce qui suggère que la liaison dynamique d'H1 pourrait conférer une protection à l'ADN dans les cas où des nucléosomes doivent être éliminés.

Des facteurs cytoplasmiques semblent être nécessaires à l'échange dynamique de l'histone H1 sur la chromatine, mais ils n'ont pas encore été spécifiquement identifiés.  La dynamique d'H1 peut être influencée dans une certaine mesure par la O-glycosylation et la phosphorylation.  La O-glycosylation d'H1 peut favoriser la condensation et le compactage de la chromatine.  Il a été démontré que la phosphorylation au cours de l'interphase diminue l'affinité d'H1 pour la chromatine et peut favoriser la décondensation de la chromatine et la transcription active.  Cependant, pendant la mitose, il a été démontré que la phosphorylation augmentait l'affinité d'H1 envers les chromosomes et favorisait donc la condensation des chromosomes mitotiques.

Isoformes
Chez les animaux, la famille H1 comprend de multiples isoformes H1 qui peuvent être exprimés au sein d'un même organisme dans des tissus et stades de développement différents ou se chevauchant .  La raison de l'existence ces multiples isoformes reste incertaine, mais leur conservation évolutive de l'oursin à l'homme ainsi que des différences significatives dans leurs séquences d'acides aminés suggèrent qu'elles ne sont pas fonctionnellement équivalentes.  L'une des isoformes est l'histone H5 , que l'on ne trouve que dans les érythrocytes aviaires, qui ne ressemblent pas aux érythrocytes de mammifères en ce sens qu'ils présentent un noyau.  Un autre isoforme est l'isoforme H1M zygotique / zygotique (également appelée B4 ou H1foo), trouvée chez les oursins, les grenouilles, les souris et les humains, qui est remplacée dans l'embryon par les isoformes somatiques H1A-E et H10 qui ressemble à H5.  Bien qu'elle ait plus de charges négatives que les isoformes somatiques, H1M se lie avec une affinité plus élevée pour les chromosomes mitotiques dans les extraits d'œufs de Xenopus.

Modifications post-traductionnelles
Comme les autres histones, les histones de la famille H1 sont largement modifiées après traduction.  Cela comprend la phosphorylation de résidus sérine et thréonine, l'acétylation et méthylation de résidus lysine, et l'ubiquitination.  Ces modifications post-traductionnelles remplissent diverses fonctions, mais sont moins bien étudiés que celles d'autres histones.

Voir également

 Nucléosome
 Histone
 La chromatine
 Linker histone H1 variants
 Autres protéines histones impliquées dans la chromatine :
 H2A  ;
 H2B  ;
 H3  ;
 H4 .

Références

Protéine

redpajama_set_name: RedPajamaWikipedia


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text:
Home Church Planting	Vancouver church closes, bequeaths building to new plant
Church PlantingNews
Vancouver church closes, bequeaths building to new plant
written by Barrie McMaster July 5, 2013
Photo: Pastor Mike Nishi stands near South Hill church in Vancouver, B.C. (Photo by MCC B.C.).
South Hill Church, a six-year-old union between two Vancouver MB congregations at 43rd Avenue and Prince Edward, is closing. Coincidentally – or providentially – it's the same area where a new C2C church plant, Christ City, is just forming.
On June 16, South Hill Church voted by more than 80 percent to disband. But the decision came with unprecedented generosity: South Hill agreed to donate its building to Christ City, allowing the newly planted MB church to start with a debt-free building.
"I was humbled by God's exceeding grace and favour toward our church plant," says Christ City pastor Brett Landry, "and humbled as a leader by [people] who would obediently and sacrificially answer God's call in this way."
The historic decision signals a shift after nearly eight decades of rich church history.
From 1945–2007, the South Hill building was home to Vancouver's first Mennonite Brethren congregation. (Vancouver MB met in rented facilities through their first decade.) As surrounding neighbourhoods changed, VMB members decided on a bold experiment in 2007, uniting with the English-speaking congregation of Pacific Grace MB Church under a new name, South Hill.
Pacific Grace pastor Mike Nishi came as leader of the new church venture. His emphasis was on discipleship and reaching out to the community, as the old German and Chinese congregations worked together to reach out to English-speaking "second-plus" generations in south Vancouver.
Nishi resigned in May of this year, effective mid-July. He says his heart remains in multiethnic ministry, and hopes to continue it in an MB setting.
Vancouver MB left a rich legacy, frequently sacrificing time and funds to plant new churches. Among them were Killarney Park MB (1961) and Culloden MB (1968). With a similar passion, South Hill offered its building in 2012 for a monthly inter-church worship night for teens, a testament to the event's spectacular growth over the previous year and a half.
Worship night youth leader Jonathan Mitchell says South Hill has an amazing history: "So much has happened in that building. It seems like holy ground in many ways."
Pacific Grace, which started in 1963 as Pacific Grace Mission Chapel, also has a church-planting history. In 2007, Nishi recorded South Hill's genesis, calling it Grace's "10th church plant." Among them are South Vancouver Pacific Grace, North Shore Pacific Grace, and two churches in Venezuela. PGMBC started Cantonese language ministry in 1974 and added Mandarin ministry in 1999.
One part of VMB's story has a particular sweetness for many members. In 1961, VMB planted Burnaby's Willingdon Church, a move which ties to the events of 2013. Several leaders from Vancouver's Westside Church came out of Willingdon. And Westside is birthing Christ City. Meanwhile, Willingdon has since adopted Landry as church planter, completing the circle of blessing.
More than coincidence
South Hill's retiring moderator Brian Ekk says, over the years, his church made a lot of contacts and "planted a lot of seeds." The decision to disband was very hard, he says. But he believes God was in the timing of the February appointment of church planter Adam Wiggins as interim associate pastor.
Ekk says Wiggins, through his contacts, knew about Landry's ministry activities, and things came together in an amazing way. "It all clicked into place," he said. "It's not a coincidence."
Barrie McMaster is the B.C. correspondent for the MB Herald.
Vancouver church closes, bequeaths building to new plant was last modified: June 22nd, 2015 by Barrie McMaster
Barrie McMaster
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Church plants are thriving, especially in the downtown core | Church For Vancouver September 12, 2013 - 10:29 am
[…] got a church planting history. They were not a dead church. They just felt like this is what God wanted them to […]


text:
#
# --- MIT Open Source License --------------------------------------------------
# PiB - Python Build System
# Copyright (C) 2011 by Don Williamson
#
# Permission is hereby granted, free of charge, to any person obtaining a copy
# of this software and associated documentation files (the "Software"), to deal
# in the Software without restriction, including without limitation the rights
# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
# copies of the Software, and to permit persons to whom the Software is
# furnished to do so, subject to the following conditions:
#
# The above copyright notice and this permission notice shall be included in all
# copies or substantial portions of the Software.
#
# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
# AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
# OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
# SOFTWARE.
# ------------------------------------------------------------------------------
#
# BuildSystem.py: Some basic build nodes and file metadata.
#

import os
import sys
import gzip
import pickle
import binascii
import Utils

#
# File metadata that persists between builds to aid dependency evaluation and
# track any changes.
#
class FileMetadata:

    def __init__(self):

        self.ModTime = 0
        self.ImplicitDeps = [ ]
        self.ImplicitOutputs = [ ]
        self.CachedModTime = None

    # Custom state implementations for the pickle module to ignore transient data
    def __getstate__(self):
        state = self.__dict__.copy()
        del state["CachedModTime"]
        return state
    def __setstate__(self, state):
        self.__dict__.update(state)
        self.CachedModTime = None

    def HasFileChanged(self, filename):

        # As calls into the OS for file times are expensive cache the result as much as possible
        if self.CachedModTime == None:

            # Modtime get will only succeed if the file exists
            try:
                self.CachedModTime = os.path.getmtime(filename)
            except:
                # If the file no longer exists, it has changed
                # Note this path will force the cached mod time to NOT update and call getmtime
                # on each evaluation. This is safe and no slower than the original implementation
                # and only triggered if you delete output files.
                return True

        # Compare modification times
        return self.CachedModTime != self.ModTime

    def UpdateModTime(self, filename):

        if self.CachedModTime != None:
            self.ModTime = self.CachedModTime
        else:
            # Only updates if the file exists
            # Faster than first checking to see if the file exists
            try:
                self.ModTime = os.path.getmtime(filename)
            except:
                pass

    def SetImplicitDeps(self, env, deps):

        # Create file nodes for each dependency
        self.ImplicitDeps = [ ]
        for filename in set(deps):
            filenode = env.NewFile(filename)

            # Ensure each dependency has a metadata entry
            env.GetFileMetadata(filename)
            self.ImplicitDeps.append(filenode)

    def SetImplicitOutputs(self, env, outputs):

        # Create file nodes for each dependency
        self.ImplicitOutputs = [ ]
        for filename in set(outputs):
            filenode = env.NewFile(filename)

            # Ensure each dependency has a metadata entry
            env.GetFileMetadata(filename)
            self.ImplicitOutputs.append(filenode)

    def __repr__(self):

        return str(self.ModTime) + "->" + str(self.ImplicitDeps) + "->" + str(self.ImplicitOutputs)

#
# Metadata that persists between builds
#
class BuildMetadata:

    OutputFilename = "metadata.pib"

    def __init__(self):

        self.Version = 2
        self.FileMap = { }
        self.FileMetadata = { }
        self.UserData = None

    def Save(self):

        with gzip.open(BuildMetadata.OutputFilename, "wb") as f:
            pickle.dump(self, f)

    def Load():

        try:
            # Open and load the metadata file if it exists
            if os.path.exists(BuildMetadata.OutputFilename):
                with gzip.open(BuildMetadata.OutputFilename, "rb") as f:
                    data = pickle.load(f)

                    # Return if the version matches
                    if hasattr(data, "Version") and data.Version == 2:
                        return data

                    print("Metadata file version out of date, discarding...")

        # Handle malformed files
        except:
            print("Error loading Metadata file, discarding...")

        # Return empty constructed build metadata if it can't be loaded
        return BuildMetadata()

    def AddToFileMap(self, filename):

        # Ignore empty filenames
        if filename == None:
            return

        # Generate the CRC
        filename = Utils.NormalisePath(filename)
        crc = binascii.crc32(bytes(filename, "utf-8"))

        # Check for collision
        if crc in self.FileMap and filename != self.FileMap[crc]:
            raise Exception("CRC collision with " + filename + " and " + self.FileMap[crc])

        self.FileMap[crc] = filename
        return crc

    def GetFilename(self, crc):

        return self.FileMap[crc]

    def GetFileMetadata(self, target, filename):

        # Ignore empty filenames
        if filename == None:
            return None

        # Create unique file metadata objects for each target so that builds
        # don't interfere with each other
        if target not in self.FileMetadata:
            self.FileMetadata[target] = { }
        file_metadata = self.FileMetadata[target]

        # Return an existing metadata?
        crc = self.AddToFileMap(filename)
        if crc in file_metadata:
            return file_metadata[crc]

        # Otherwise create a new one
        data = FileMetadata()
        file_metadata[crc] = data
        return data

    def UpdateModTimes(self, target):

        # It's safe to update the mod times for any files which were different since the last build
        file_metadata = self.FileMetadata[target]
        for crc, metadata in file_metadata.items():
            metadata.UpdateModTime(self.GetFilename(crc))

#
# Base node for the dependency graph
#
class Node:

    def __init__(self):
        self.Dependencies = [ ]

    def GetInputFile(self, env):
        raise Exception("Derived class hasn't implemented GetInputFile")

    def GetOutputFiles(self, env):
        raise Exception("Derived class hasn't implemented GetOutputFiles")

    def GetTempOutputFiles(self, env):
        return self.GetOutputFiles(env)

#
# A file node is simply an ecapsulation around a file on disk with no build step
#
class FileNode (Node):

    def __init__(self, crc):

        super().__init__()
        self.CRC = crc

    def GetInputFile(self, env):
        return env.GetFilename(self.CRC)

    def GetOutputFiles(self, env):
        return [ env.GetFilename(self.CRC) ]

#
# Used to depend on output files from build steps
# Bound to the environment that generates the output file
#
class OutputFileNode (Node):

    def __init__(self, env, node):

        super().__init__()
        self.Env = env
        self.GetInputFileFunc = node.GetInputFile
        self.GetOutputFilesFunc = node.GetOutputFiles

    def GetInputFile(self, env):

        return self.GetInputFileFunc(self.Env)

    def GetOutputFiles(self, env):

        return self.GetOutputFilesFunc(self.Env)

#
# A file copying node that can be placed anywhere in the dependency chain, always
# returning True on Build
#
class CopyNode (Node):

    def __init__(self, output, source, dest):

        super().__init__()
        self.Dependencies = [ output ]
        self.Source = source
        self.Destination = dest

    def Build(self, env):

        if not os.path.exists(self.Source):
            Utils.Print(env, "   ERROR: Source file doesn't exist")
            return False

        Utils.Print(env, "Copying from " + self.Source + " to " + self.Destination)
        if Utils.Makedirs(os.path.dirname(self.Destination)) == False:
            Utils.Print(env, "   ERROR: destination directories couldn't be created")
            return False
        if Utils.CopyFile(self.Source, self.Destination) == False:
            Utils.Print(env, "   ERROR: Copy operation failed")
            return False

        return True

    def GetInputFile(self, env):
        return self.Source

    def GetOutputFiles(self, env):
        return [ self.Destination ]

redpajama_set_name: RedPajamaGithub


text:
Q: wildcards in asp.net mvc routes i'm using asp.net mvc with vs2008 and IIS7.
What i want to accomplish is that all requests that START WITH 'summer' are routed to the same controller.
'till now i've built tons of routes, but they were all for one path (with parameters offcourse) but this one must route:
www.mysite.com/summercity
www.mysite.com/summermadness
www.mysite.com/summer
www.mysite.com/summerweather
to the same controller.
the only solution i've come up with is 'summer*', but that didn't work :)
Michel

A: You can use:
/Summer{*Data}

redpajama_set_name: RedPajamaStackExchange


IJC members who have lost a loved one and would like to have their name included in IJC's yahrzeit list (with annual reminders) please contact Harriet Behrman – communitycare@ijc.be – who will make the necessary arrangements. Yahrzeit names are read out during services on the closest Shabbat to the date and Kaddish is said by the community.
IJC has a stock of Yahrzeit candles which are available to members free of charge. Please contact Harriet Behrman during services.


Properties in location/andheri-west/tt/sale listed below !
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Starting in 2016, a new series of reports will monitor the state of education in the framework of the anticipated Sustainable Development Goals (SDGs) to be finalized by the UN in September 2015. The first report in this series, the 2016 Report, will focus on 'Education, sustainability and the post-2015 development agenda', as decided with the strong support of the GMR Advisory Board. The 2016 report will carefully consider how education and major development sectors are inter-related, and determine which education strategies, policies and programmes are most effectively linked to the economic, social, environmental and political priorities of the new sustainable development agenda. The report will also establish a new monitoring framework for education, and examine key financing and governance challenges for the post-2015era.
We are keen to hear your views on the chosen theme and the specific issues outlined. Your comments will contribute to our thinking on education's role in sustainable development, and help shape the contents of the 2016 report. We are particularly interested in hearing from experts in non-education development sectors, as well as from researchers, sector experts, practitioners, teachers, governments, non-governmental organizations, and aid donors. If you have a strong interest in education and development, please consider sharing your views.
We would greatly appreciate your help in circulating this message to your respective local, national and regional networks.
Should you require any further information please contact the GMR Team at efareport@unesco.org.


text:
Lucy Pawlak: The Halfway House
You are cordially invited to The Halfway House One thousand years ago tomorrow from a room between London and Warszawa with Lucy Pawlak and special guests Martin Clark and Gil Leung.
The Halfway House is neither here nor there. It is not "now" or "then". It could be the inn midway between two towns (a service station or a travel lodge) or a house for prisoners crossing from inside to outside. It might recall absent rooms or present events passed.
The Halfway House at domobaal will consist of two filmed spaces; both are shot in and around a flat in Warsaw, Poland. The flat operates as a site for an ongoing series of collaborative projects Pawlak is involved in, as well as for her own film project.
"Here in Warsaw on Ulica Wspólna 71/9 I am surrounded by cracks and gaps, marks and loose wires, is this the beginning of my breakdown? The flat was previously an office – each wall has internet connection cords spurting from it, the ceilings are false and covered with plastic tiles – the signifier for 'office'. The light patches on the yellowing walls are the ghosts of spreadsheets and timetables. Everything is labeled 'high security' – the windows all have a sticker that announces S.M.A. SYSTEM MONITOROWANIA ALARMÓW and a phone number for a dial–a–vigilante service – I suppose it was full of computers once upon a time. The bars that are on every window don't seem to bother me. The alarm system flashes red and green and appears to be trying to decide between calling the police, the fire brigade or an ambulance. It only ever says it is 'ready', so far it has not flicked to 'ARMED' so I have resolved not to touch it – 'ready' seems preferable to 'ARMED'. Motion sensors are fixed in the corner of every room – the blank white faces gaze down at me benevolently and when I get out of bed at night a green l.e.d. blinks on and off. Amongst the flat's various stunning original features is a radiator that has crawled halfway up the wall, everyone says it is typical of communism – bad design and impractical, but I like it. Another original feature worthy of note is a soiled poster of the woods that had been stuck lopsided below the radiator. It seems deeply tragic but tinged with sweetness – the parting gift from the previous residents – "take this, you are going to need it…" My little apartment block crouches in the shade of the gleaming glinting black rectangle that is the Marriott Hotel, complete with Casino, Caviar, Panorama Bar on the 40th floor and Sushi Snacks."
In 'Scene One' (the first filmed space) we observe the private realm of Pawlak's made up family – Bearded Man, Naked Woman, Old Gentleman and Elderly Lady inhabit a shed in the darkest part of the Primal Forest. Seated within a kind of tableau vivant or thought out world, they might be observed like animals at a zoo. "I chomp, swallow and suppress a belch and suddenly you are conscious of the clock ticking. I sit alone at my desk, the radio is on across the courtyard; the sound of china plates against each other as they prepare Sunday lunch makes me feel alone. Someone is playing the piano on the top floor, the old lady above me shifts closer to the window. The sniffer in the concert hall, the horror when laughter turns into a snort, when do we notice such things? The awkward shapes formed by someone picking their way across a stream or anxiously weaving through traffic on a busy road, pushing through brambles and stinging nettles in the wood or people in a crowded room at a party, trying not to sink into the mud or slip on the bathroom floor, clambering up a steep bank or along a busy platform.
Pawlak is drawn to film's relationship to estrangement, fractured narratives and madness. Like an autobiography of numerous selves and others contained in one book, the individual is the embodiment of many subjects. There is a futility to all attempts at being master of the object of one's vision.
The film will form a part of Pawlak's one man band Hollywood project, in which she attempts to become director, producer, cast and crew rolled into one. This method imposes certain limitations on the filming process, for example the characters cannot actually touch one another. She plans to shoot 12 minutes of 16mm footage per year over the course of 12 years so as to achieve a feature length movie. She has completed the title sequence and is currently working on "Special Features" (a commentary or 'making of' in which the director reminisces about life on set, though he has not yet begun filming) as well as "Scene One" of the movie.
"Scene One" and "Special Features" will be available to purchase as a handmade anniversary DVD box set priced at £20.
"I live alone in 71/9 on the ground floor, my windows look out onto the communal courtyard. The fat lady with the dog made of 100% muscle smiles and waves at me. The caretaker asked if I had a boyfriend yet, she said I should have one, because my hair is so pretty; I think she is only saying this because she knows my hair was butchered by the Siberian Hairdresser who rents a salon at the front of the building, and she hopes to defend him. I nearly cried – he would not stop cutting. When he was a little boy his mother packed him off to train at the Bolshoi Ballet, but for some reason he had to switch to hairdressing instead. The old ladies like to hang out on the red plastic sofa in his salon. They all witnessed the scene – I only wanted a trim but he snipped away and tears started to prick my eyes, I ducked my head down and called out "Stop! Stop!" Actually it didn't look too bad but I started to panic because I thought he wasn't listening."
Collaboration is difficult and vital. The second filmed space in the Halfway House is M.C.4L.P. a film by Martin Clark and Lucy Pawlak. The film is a romance in which Clark and Pawlak direct one another and perform the lead roles. Both the content of the film itself and the working relationship formed during the making of it deal with control and loss of control. Pawlak and Clark have a shared interest in the nature that opens itself to the camera. "We lived together at Madame Lillie's Corset Shop in Stoke Newington and slept in neighboring rooms with our beds against the same wall. Martin suggested we collaborate on a film because we tread similar boards – an interest in the 'acting-out' or 'performance of' particular roles features in both our practices."
People say the experience of watching a film might be a little like a fling, "I pick you up, whirl you around and drop you down". Each shot within the romantic montage lasts 5 seconds, there is no beginning to the story, it only revolves seamlessly in a never–ending cycle of meeting and parting. Where are the dream factories? Are they in the park or at the bus stop? What is our relationship to a scene from a blockbuster, a clip from a music video, a snatch of a song, a picture of a sunset or a girl on a swing? Interestingly, Warsaw Old Town, (where parts of the film were shot), was rebuilt entirely from 18th century paintings by Canaletto. Eighty-five percent of Warsaw was destroyed in World War Two, the Old Town and its castle were a heap of rubble, but throughout the 50's, 60's and 70's the Poles pieced the palace and surrounding area together by scrutinizing Canaletto's careful brushwork. It was built out of a representation of itself, so it really is pretty as a picture.
"Once again we see performed the timeworn Greek melodrama: Orpheus, Eurydice and Hermes at the station. Through the mountains of luggage surrounding the figure of the Nymph, looms the steep and rocky path, the crypt into which she sinks when the Hermaic conductor with the signal disk, watching for the moist eye of Orpheus, gives the sign for departure. Scar of departure, which zigzags, like the crack on a Greek vase, across the painted bodies of the Gods"
Walter Benjamin, The Arcades Project (Harvard University press, 2002) p.406
After a week of filming in Warsaw Martin and I flew to Scotland to edit. When I finally return to my 4 rooms they will seem a little more empty – faint smell on my pillow might remain and some splashes of piss at the base of the toilet bowl – the only trace of Martin who lives alone in Glasgow.
We conversed while sitting in grubby armchairs in the installation of a sweatshop in Brick Lane, we chatted while walking down the valley carved out by a glacier in the Caucasian mountains, we argued at the top of the Empire State building or ended it in my room in Camberwell and all at once we could have been anywhere.
Full of irreverence bordering almost on contempt, I walk with dignity into the massive cool building made of granite. I climb unimpressed up the marble staircase rescued from the fire and covered with a red carpet, religiously shaken out every morning by the over tired, ever complaining char woman. I pay no attention to the newly installed windows and the freshly painted walls of the restored building. I enter with a casual air the modest but cosy little rooms occupied by people of importance and ask, perhaps a trifle too politely, for things that are perhaps too trivial, but to which none the less I am entitled – but which, of course, cannot keep the world from swelling and bursting like an over–ripe pomegranate, leaving behind but a handful of grey, dry ashes.
Tadeusz Borowski 'This Way for the Gas, Ladies and Gentlemen' (Penguin Books, 1976), p.179
The second collaboration within the show is a text written in 'partnership' with Gil Leung. It might act as a circular argument with Leung playing the part of The Interlocutor and with Pawlak in the role of The Proposer. These antagonistic identities, and the authority that accompanies them, shift as the conversation ceaselessly engages and abandons its different narrative constructs.
"'Wspólna' the name of my street, means something close to partner, collaborator or accomplice. Wspólny can be translated as common or mutual. I like this in relation to my plans to use the flat itself for various forms of collaboration. Wspólnymi siłami = with combined efforts. Wspólna mogila = mass grave (some people think of Poland as a mass grave). Wspónota = community. Ulica Wspólna in its heyday was full to bursting with prostitutes, today a few remain, to be precise a sisterhood of 7 or 8 ladies who look as though they could be your Mother or Babcia, and who have quite possibly worked the same strip since they were girls. The Wspólna women are built like tanks and even without their huge shoulder pads they would be formidable. They don't really seem much like whores, one lady likes to dress all in red, but it's not exactly Roxanne's Red Dress, but rather a sort of baggy red suit and red trainers combined with a shock of orange-cropped hair, sure, she stands on the corner, but she has her nose permanently in a book. Last night as I was walking home a White Van Man tried to pick me up for a screw; my first fear was that one of the sisters might think I was moving in on their turf. I keep wondering if these arthritic street walkers chase the fresh meat off their territory, or whether the fresh meat prefers to stay indoors – the streets of Warsaw are awash with calling cards – 'Buy two hours and get the third free…' Three hours! That seems like a long time to me."
Jan Belina Brzozowski, Fabian Czolbe, Robert Dennis, Thomas Fossgård, Robert Hardy, Carlo Jelavic, James Kambietz, Tato Kotetishvili, Gil Leung, Jolanta Pawlak, Susan Pawlak, Witold Pawlak, The Parsonage, Alex Pearce, Elizabeth Pruszynski, Professor Stanisław Szymański, Angela Święc and The Showroom, London.
They think, that they didn't know each other earlier,
nothing ever happened between them.
But what would they say: those streets, stairways and corridors
where they could have been passing each other for a long time?
I would like to ask them,
don't you remember–
maybe face to face once
in a revolving door?
an "excuse me" in a tight crowd?
a 'wrong number' heard over the phone?
–but I know their answer.
No they don't remember.
An extract from 'Love at First Sight' Wisława Szymborska, Miracle Fair (W.W Norton & Co. 2001), p30
Lucy Pawlak completed a BA in graphic design before graduating from the RCA painting department last summer. She recently exhibited in the Jerwood contemporary painters and will spend the next year at Lodz Film School.
Martin Clark graduated from the Photography department at the RCA in 2006, he studied for his BA at Glasgow School of Art. He now lives in Glasgow where he works as a photographer and film maker.
Gil Leung is studying for her MA in Aesthetics and Art Theory at the Centre for Research in Modern European Philosophy, Middlesex. She currently works for Tate and Afterall. She is a free–lance writer.
Fabian Czolbe studies Humanities at Humboldt–University, Berlin, his focus is on Music, Theatre, Dance and the links between vivid music and art. Fabian plays jazz, free jazz and free improvisation with various ensembles often with theatrical connections.
>Shop: publications, comics, dvds by Lucy Pawlak
For a selection of further text and reviews click on titles below to download:
>The Lives (of the Most Excellent Artists) – Haverstock School. A workshop project devised and led by Lucy Pawlak as part of the Frieze Fair Education Programme 2008 in association with Deutsche Bank, facilitated by ReachOut RCA; and with thanks to Michele Panzeri (Photography) Adam James (Make–Up) and the teachers: Mr Pype and Mrs Keogh. A–Level students from Haverstock School performed as art anthropologists with the intention of studying the art world, the art fair and the artist. The workshop was structured using a basic scientific methodology. The study required a rigorous scrutiny of primary and secondary sources. Following a period of extensive research, students conducted interviews with artists, gallerists, private collectors and art buyers, including: Alistair Hicks, Domo Baal, John Strutton, Leigh Message, Maxine Leslau. The aim of the study was to create characters based upon the findings. In conclusion each student posed as the personality they had designed in the education space at the Frieze Art Fair. These photographic portraits are the final result of this investigation. To create a lively character, an in–depth study is required. October 2008 (2.1 MB, 11 pages)
>The Lives (of the Most Excellent Artists) – Pimlico Academy [see above] October 2008 (2.1 MB, 12 pages)
>Lucy Pawlak's pages from the PKZ publication, Paul Klee Zentrum Sommer Akademie Catalogue. August 2008 (1 page)
>Dialogue No. 1345, written by Lucy Pawlak. Between a buried single room and a pitched one–man tent. A text for a soundpiece exhibited at Zentrum Paul Klee Sommer Akademie, August 2008, and at Villa La Tourelle, Oostende, Belgium. "Lucy Pawlak's work refers to the feral underbelly of a 'life inside the grave' that alternates between the social and the savage. Her sound installation for the Summer Academy introduces us to the ancient female figure of the Anchorite who lives an existence so internal and solitary that she metaphorically crawls into Christ's heart–shaped wound or finds solace in the uterus of the Virgin Mary. Pawlak's second character is the male Hermit, whose early pilgrim trails and ardent fervor led to the constitution of monasticism and the formation of Benedictine institutions. In the 19th century, the Hermit's role takes on a somewhat absurd turn, as he becomes a feature of English pastoral follies, commissioned to perform for the gentry as a human garden ornament that inhabits a man–made cave." Clementine Deliss writing in the introduction to the PKZ Sommerakademie publication. September 2008 (18 pages)
>Rebecca Geldard, an excerpt from Rebecca Geldard's essay for 'Oyster Grit' a group exhibition at domobaal gallery. September 2007 (1 page)
>Time Out 'Pick of the Week', Martin Coomer's review of The Halfway House, Lucy Pawlak's solo show with Special Guest Collaborators Martin Clark and Gil Leung at domobaal. September 2007 (1 page)
>City A.M. Review, review of The Halfway House, by Henry Carroll. September 2007 (1 page)


text:
Intellia Therapeutics Announces Proposed Public Offering of Common Stock
Intellia Therapeutics, Inc.
CAMBRIDGE, Mass., Nov. 30, 2020 (GLOBE NEWSWIRE) -- Intellia Therapeutics, Inc. (NASDAQ:NTLA), a leading genome editing company focused on developing curative therapeutics using CRISPR/Cas9 technology both in vivo and ex vivo, announced today that it has commenced an underwritten public offering of $150 million of shares of its common stock. Intellia also intends to grant the underwriters a 30-day option to purchase up to an additional fifteen percent (15%) of the shares of common stock offered in the public offering. All of the shares in the proposed offering are to be sold by Intellia.
Goldman Sachs & Co. LLC, Jefferies and SVB Leerink are acting as joint book-running managers for the proposed offering. The offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.
The shares of common stock are being offered by Intellia pursuant to a shelf registration statement that was previously filed with, and subsequently declared effective by, the U.S. Securities and Exchange Commission (SEC). A preliminary prospectus supplement and accompanying prospectus relating to and describing the terms of the offering will be filed with the SEC and may be obtained, when available, from: Goldman Sachs & Co. LLC, by mail at 200 West Street, New York, NY 10282, Attention: Prospectus Department, by telephone at (866) 471-2526, or by email at prospectus-ny@ny.email.gs.com; Jefferies LLC, by mail at 520 Madison Avenue, 2nd Floor, New York, NY 10022, Attention: Equity Syndicate Prospectus Department, by telephone at (877) 547-6340, or by email at Prospectus_Department@Jefferies.com; SVB Leerink LLC, by mail at One Federal Street, 37th Floor, Boston, MA 02110, Attention: Syndicate Department, by telephone at (800) 808-7525, ext. 6132, or by email at syndicate@svbleerink.com; or by accessing the SEC's website at www.sec.gov.
This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.
About Intellia Therapeutics
Intellia Therapeutics is a leading genome editing company focused on developing proprietary, curative therapeutics using the CRISPR/Cas9 system.
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding Intellia's anticipated public offering. The words "may," "will," "could," "would," "should," "expect," "plan," "anticipate," "intend," "believe," "estimate," "predict," "project," "potential," "continue," "target" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release, such as the intended offering terms, are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, uncertainties related to market conditions and the completion of the public offering on the anticipated terms or at all. These and other risks and uncertainties are described in greater detail in the section entitled "Risk Factors" in Intellia's most recent annual report on Form 10-K and quarterly report on Form 10-Q filed with the SEC, as well as discussions of potential risks, uncertainties, and other important factors in Intellia's other filings with the SEC, including those contained or incorporated by reference in the preliminary prospectus supplement and accompanying prospectus related to the proposed public offering to be filed with the SEC. Any forward-looking statements contained in this press release represent Intellia's views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. Intellia explicitly disclaims any obligation to update any forward-looking statements, except as required by law.
Intellia Contacts:
Lina Li
lina.li@intelliatx.com
Jennifer Mound Smoter
External Affairs & Communications
jenn.smoter@intelliatx.com


National Palliative Care Week: It's Time to Talk About Dying.
As National Palliative Care Week comes to a close, we feel it is important to reflect on one of the initiative's most important messages; the need to talk about death.
For most, death is not a preferred topic of conversation. In fact, it makes many people uncomfortable, and these feelings are only multiplied when the conversation in question is about a loved one.
However, Australia's governing body for palliative care, Palliative Care Australia (PCA), believes talking about dying is absolutely vital for those living with chronic illness.
These conversations are especially critical for those living with complex, chronic diseases. These kinds of diseases cover the five leading causes of death according to the Australian Institute of Health and Welfare.
But according to a recent survey conduced by Palliative Care Australia, the majority of sufferers of these serious conditions do not have adequate plans in place to ensure their doctors and loved ones understand what they want at the end of their life. Only 28% of respondents had spoken to their loved ones about how they want to be cared for at the end of their life.
Despite common beliefs, Palliative care is much more than care during the last days or weeks of a person's life and is not a service of "last resort". Even when a cure to a serious illness is not possible, active treatment and appropriate support may continue to manage the symptoms and course of the disease. This process may involve many important choices that will impact the last stages of someone's life, and their ability to have realistic and conscience input is made more likely by having having these conversations.
Motor Neurone Disease Australia National Executive Director Carol Birks says "Writing your wishes down or talking about them can help give you a sense of control over your future. This can be particularly important for people living with motor neurone disease, who often experience a spiralling series of losses".
They are also extremely important for loves ones throughout this difficult time. Being aware of what their loved one wants at the end of their life can reassure them if and when they are forced to make difficult decisions.
Respondents from the above survey were asked to nominate three issues they would consider most important if they were dying, and the results can provide some great starting points if you are stuck on how to initiate this conversation. The top three were being free from pain and physical distress, being free from psychological distress and being in the place of their choice (home, hospital, hospice or aged care).
At Prestige, we offer a comprehensive palliative care service, from planning the process right through to carrying it out with our specifically trained carers and nurses.
For more information on our palliative care services, call us on 1300 10 30 10 or click here.
You can also visit www.palliativecare.org.au for many useful resources on the palliative care process.