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Water Under Fire Volume 3: Attacks on water and sanitation services in armed conflict and the impacts on children
Attacks on water and sanitation facilities in conflict zones around the world are putting the lives of millions of children around the world in danger, and are a much greater threat than violence itself,
P akistan
Downward Spiral: the economic impact of Covid-19 on refugees and displaced people

This report is based on a survey of 1,400 people affected by conflict and displacement in eight countries, and more detailed surveys and needs assessment in a total of 14 countries. The Norwegian Refugee
Norwegian Refugee Council (NRC)
Consequences Of Underfunding In 2020

UNHCR is mandated to provide protection, assistance and solutions for refugees, asylum-seekers, returnees, stateless persons, internally displaced people and others of concern to the Office, of whom
United High Commissioner for Refugees (UNHCR)
UNHCR AND WFP Extend Assistance Net To Cover Displaced And Refugee Families Affected By Pandemic

The UN Refugee Agency (UNHCR) and the United Nations World Food Programme (WFP) are stepping up their collaboration to help meet the essential needs of vulnerable people in Iraq. WFP has worked with
Regional Overview of Food Security and Nutrition in the Near East and North Africa 2019

Today, nearly 55 million people in the Arab States, 13.2 percent of the population, are hungry and the situation is particularly worrying in countries affected by conflicts and violence: Iraq, Libya,
UNHCR's Initiative on Internal Displacement 2020 – 2021

As a complement to agency-wide efforts across all its IDP operations, UNHCR’s engagement in internal displacement will be further concretized, supported and driven forward on a focused and demonstrative
Renewable solutions for refugee settlements: sustainable energy access in humanitarian situations
Refugees and displaced people mostly depend on energy that is unsustainable and can harm their health and well-being. Sustainable energy based on renewables, in contrast, bridges the gap between humanitarian
New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis

Existing WHO estimates of the prevalence of mental disorders in emergency settings are more than a decade old and do not reflect modern methods to gather existing data and derive estimates. <a href="http://www.indiaenvironmentportal.org.in/files/file/mental-disorders-conflict-settings.pdf"
Iraq floods leave 21 dead in two days: health ministry
Iraq is one of the hottest countries on earth but when heavy rains do hit they can result in casualties and widespread damage because of deteriorating public infrastructure. At least 21 people have died
PHYS
Heavy metals, ammonia blamed for Euphrates carp deaths: WHO
The death of thousands of freshwater fish in the Euphrates river in Iraq was due to high levels of coliform bacteria, heavy metals and ammonia in the water, the World Health Organization (WHO) said. Thousands
Freshwater Ecosystems


Mild anxiety is normal and can result from positive events, like a birthday or marriage, as well as negative events like school failure, loss of a friend, divorce or a death in the family. Traumatic events and or cumulative stress can overwhelm a child and cause extreme anxiety and ineffective coping responses. Anxiety reactions can range from complete withdrawal to volatile emotional over-reactions. Children who have obsessive compulsive disorder (OCD) or traits of that condition can also be very rigid and fall apart easily when their expectations are not met. Excessive worrying can turn into full blown panic over parental separation, weather, barking dogs, insects, food spoiling, home burglary, airplane trips and numerous other unrealistic fears. Perfectionistic tendencies can also cause undue anxiety and stress when the child fails to perform as well as expected in sports or school.
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ASIA & OCEANIA / Lockdown may contain Covid-19, but it can't curb the virus of Islamophobia in India
Translations available: Deutsch
Lockdown may contain Covid-19, but it can't curb the virus of Islamophobia in India
Priya Ramani प्रिया रमानी
If 2018 and 2019 were the years India communalised rape, 2020 will go down as the year this country viewed a global pandemic through a Hindu-Muslim lens.
One hate cartoon circulating on social media
Activist Akram Akhtar was home in Shamli, Uttar Pradesh, when the clock struck 9 pm on 5 April, and the soundtrack of those responding to Prime Minister Narendra Modi's call for a 9-minute lights-out echoed around him.
"There were loud shouts of Jai Shri Ram, firecrackers and the distinctive sounds of .315 calibre country-made pistols being fired. I heard the conch and prayer bells from the temple where loudspeakers played bhakti songs." This continued for 45 minutes, he said.
In other parts of India too, Modi's call to switch off lights and light a diya or shine a torch "to mark our fight against coronavirus" was interpreted by many Hindus as a show of majoritarian strength.
Worried that there might be communal tension, Akhtar got on his motorcycle and drove to some Muslim neighbourhoods. "It was dark and quiet. Unlike other days, not one person was on the road," he added, attributing this to the fear fueled largely by the recent police violence against Muslim citizens protesting against the Citizenship (Amendment) Act in Uttar Pradesh (UP).
Corona fuels Muslim hatred
Since December, police in India's most populous state has targeted Muslims, detaining thousands, raiding homes and even opening fire on people protesting against new laws that will put Indian citizenship through a religious sieve.
A bald headline in Time magazine holds up a clear mirror to our recent selves: "It Was Already Dangerous to Be Muslim in India. Then Came the Coronavirus."
After attendees at a Tablighi Jamaat meet — held in Delhi before Modi's call for a national lockdown — tested positive, fake news about Muslims intentionally spreading the coronavirus went viral. As India trended #CoronaJihad, our Islamophobia was on show for the world to see.
An indication of how fast the hateful rumours spread was that even the UP Police was forced to turn fact-checker.
In Sahranpur, 62 km from Shamli, the police issued a statement denying that Jamaatis quarantined in Rampur "created a ruckus" because they didn't get non-vegetarian food and had excreted in the open. "After going through news reports, news channels and social media posts we have found that these reports are completely wrong and untrue. Saharanpur Police refutes this projected news in its entirety," the official police handle tweeted.
After this, there were many more instances of the UP Police correcting and warning or arresting people and media organisations for spreading fake news or attacks against Muslims. An article in the Hindustan newspaper dated 6 April said the Meerut police found to be untrue the report that a maulana had spat on and bitten a shopkeeper. The shopkeeper was angry after an altercation over money and had used a coin to create bite marks.
Fake news and real damage
Courtesy of The Print
Source: https://theprint.in/opinion/lockdown-may-contain-covid-19-but-it-cant-curb-the-virus-of-islamophobia-in-india/398943/
Tags: Coronavirus crisis | Islamophobia | Hindutva | Communalism | India

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KLDO
Kaleido Biosciences
The Daily Biotech Pulse: DBV's Positive FDA Feedback, Pfizer's Cancer Drug Gets Label Expansion, Applied DNA COVID Testing Volume Surges
Here's a roundup of top developments in the biotech space over the last 24 hours. Scaling The Peaks (Biotech Stocks Hitting 52-week Highs Jan. 14)
Benzinga · 3d ago
Kaleido Bio's KB109 shows benefit in COVID-19 study
Kaleido Biosciences (KLDO) +2% in premarket has announced interim data from K031 non-IND controlled clinical study evaluating Microbiome Metabolic Therapy ((MMT)) candidate KB109 plus Supportive Self Care ((SSC)) in patients with mild to moderate COVID-19
Seekingalpha · 4d ago
The Daily Biotech Pulse: Alexion Pauses COVID-19 Study, NantKwest Readout, Organogenesis Jumps On Guidance, Trial Updates
Here's a roundup of top developments in the biotech space over the last 24 hours: Scaling The Peaks (Biotech Stocks Hitting 52-week Highs Jan. 13)
DJ Kaleido Biosciences Early Results Show Promise in Covid-19 Patients
Dow Jones · 4d ago
Kaleido Biosciences Announces Positive Interim Results of Controlled Study of KB109 in Patients with Mild-to-Moderate COVID-19
Preliminary analysis (n=176) demonstrates favorable safety and tolerability; data provide a strong signal of clinical benefit for subjects reporting one or more comorbidities
GlobeNewswire · 4d ago
Preliminary analysis (n=176) demonstrates favorable safety and tolerability; data provide a strong signal of clinical benefit for subjects reporting one or more comorbidities Topline data from full study population of 350 patients and results of second study of KB109 are expected in the first quarter of 2021 LEXINGTON, Mass., Jan. 14, 2021 (GLOBE NEWSWIRE) -- Kaleido Biosciences, Inc. (Nasdaq: KLDO), today announced positive interim results from the K031 non-IND controlled clinical study evaluating outpatients with mild to moderate COVID-19 disease. Patients in this non-IND clinical study were randomized within 48 hours of testing positive for COVID-19 to either receive Supportive Self Care (SSC) or SSC plus Microbiome Metabolic Therapy (MMT™) candidate KB109 for two weeks and then followed for an additional three weeks. The planned interim analysis comprised approximately half of the total study population (n=176) and showed that KB109 was well tolerated, with a safety profile consistent with previous studies of MMT candidates and no unexpected treatment-related adverse events. For subjects reporting one or more comorbidities, the median time to resolution of the thirteen overall COVID-19 related symptoms was 18 days with KB109 plus SSC and 27 days with SSC alone."This interim analysis, from the largest study conducted to date with an MMT candidate, reinforces the safety and tolerability previously observed with MMTs and provides a strong signal of clinical benefit for KB109," commented Dan Menichella, President and Chief Executive Officer of Kaleido. "The study reveals that many patients with mild-to-moderate disease, and particularly those patients with a comorbidity, experience symptoms for a period of weeks. This study shows the significant burden experienced by these patients and we look forward to reporting the full dataset later this quarter.""These exciting and relevant data are in line with what we are seeing in the COVID-19 literature and suggests that the microbiome plays a role in this disease," said John P. Haran, M.D., Ph.D., associate professor of emergency medicine, microbiology & physiological systems and clinical director of the UMass Center for Microbiome Research at the University of Massachusetts Medical School. "There is increasing evidence supporting the biological plausibility that microbiome restoration has a significant impact on different diseases and seeing an influence in COVID-19 patients with comorbidities aligns with this emerging science."Summary of Interim Results * KB109 demonstrated a favorable safety and tolerability profile with no unexpected treatment-related adverse events or discontinuations related to treatment. * Approximately 40 percent of the patients reported at least one comorbidity at baseline. * The presence of comorbidity lengthened the time to resolution of symptoms, even in mild to moderate COVID-19 disease. In the SSC alone arm, median time to resolution of the thirteen overall COVID-19 related symptoms in patients with no comobitities was 14 days as compared with 27 days in patients with at least one comorbidity. * No difference in median time to resolution of symptoms was observed with KB109 plus SSC for the overall population, although small differences between the arms were observed during the follow-up period. * Median time to resolution of the thirteen overall COVID-19 related symptoms for patients with one or more comorbidity at baseline was 18 days for the KB109 plus SSC group as compared with 27 days with SSC alone. * Kaleido also evaluated eight cardinal COVID-19 related symptoms as defined by the Centers for Disease Control and Prevention, which showed median time to resolution of symptoms among patients with one or more comorbidity at baseline was 15 days for the KB109 plus SSC group as compared with 27 days with SSC alone.The K031 study of 350 subjects is fully enrolled with results expected in the first quarter of 2021. Topline data from a smaller 50 subject study of KB109 is also expected in the first quarter of 2021. About the Potential Role of the Microbiome in COVID-19 COVID-19 infection has been associated with activation of an inappropriate inflammatory cascade, which in some patients can cause an abnormally aggressive immune response that can lead to pneumonia and respiratory failure. Metabolites such as short chain fatty acids (SCFAs) produced by the microbiome through utilization of glycans are modulators of the immune response and therefore could play a role in limiting this inflammatory cascade.In preclinical models, increased SFCAs and/or SFCA-producing taxa, have been shown to influence immune pathways, mitigate immune pathology, and improve survival and morbidity associated with severe respiratory viral infections.1,2 Commensal microbiota composition critically regulates the generation of virus-specific CD4 and CD8 T cells and antibody responses following respiratory influenza virus infection.3In-human data also support the role of SCFAs in reducing the impact of viral infections. In patients undergoing hematopoietic stem cell transplants who have contracted respiratory viral infections, including coronavirus, the presence of SCFA-producing taxa has been associated with a significantly reduced risk of progression to lower respiratory tract infections, which can have substantial morbidity in this patient population.4 KB109 is Generally Recognized as Safe (GRAS) and was selected for evaluation in these COVID-19 clinical studies based on its demonstrated ability to increase production of SCFAs as well as to promote commensal bacteria and reduce pathogenic bacteria ex vivo.About Microbiome Metabolic Therapies (MMT™)Kaleido's Microbiome Metabolic Therapies, or MMTs, are designed to drive the function and distribution of the microbiome's existing microbes in order to decrease or increase the production of metabolites, or to advantage or disadvantage certain bacteria in the microbiome community. The Company's initial MMT candidates are targeted, synthetic glycans that are orally administered, have limited systemic exposure, and are selectively metabolized by enzymes in the microbiome. Kaleido utilizes its discovery and development platform to study MMTs in microbiome samples to rapidly advance MMT candidates rapidly into clinical studies in healthy subjects and patients. These human clinical studies are conducted under regulations supporting research with food, evaluating safety, tolerability and potential markers of effect. For MMT candidates that are further developed as therapeutics, the Company conducts clinical trials under an Investigational New Drug (IND) or regulatory equivalent outside the U.S., and in Phase 2 or later development.About Kaleido BiosciencesKaleido Biosciences is a clinical-stage healthcare company with a differentiated, chemistry-driven approach to targeting the microbiome to treat disease and improve human health. The Company has built a proprietary product platform to enable the rapid and cost-efficient discovery and development of novel Microbiome Metabolic Therapies (MMT™). MMTs are designed to modulate the metabolic output and profile of the microbiome by driving the function and distribution of the gut's existing microbes. Kaleido is advancing a broad pipeline of MMT candidates with the potential to address a variety of diseases and conditions with significant unmet patient needs. To learn more, visit https://kaleido.com/.Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding the therapeutic potential of our MMT candidates, the timing of initiation, completion and reporting of results of clinical studies, and our strategy, business plans and focus. The words "may," "will," "could," "would," "should," "expect," "plan," "anticipate," "intend," "believe," "estimate," "predict," "project," "potential," "continue," "target" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those related to the breadth of our pipeline of product candidates, the strength of our proprietary product platform, the efficiency of our discovery and development approach, the fact that interim results from KB013 may not accurately predict final results from KB013 and that such final results may not support continued development of KB109, the clinical development and safety profile of our MMT candidates and their therapeutic potential, whether and when, if at all, our MMT candidates will receive approval from the U.S. Food and Drug Administration and for which, if any, indications, competition from other biotechnology companies, and other risks identified in our SEC filings, including our most recent Form 10-Q, and subsequent filings with the SEC. We caution you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. We disclaim any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. 1. Antunes, K.H., et al. Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nat Commun. 2019, 10, 3273. 2. Trompette, A., et al. Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism. Immunity. 2018, May 15;48(5):992-1005.e8. 3. Ichinohe, T., et. al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proceedings of the National Academy of Sciences. Mar 2011, 108 (13) 5354-5359. 4. Haak, B.W., et al. Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT. Blood. 2018. 131, 2978-2986.Contacts Kaleido Biosciences William Duke, Jr. Chief Financial Officer 617-890-5772 william.duke@kaleido.comInvestors Mike Biega Solebury Trout 617-221-9660 mbiega@soleburytrout.comMedia Rich Allan Solebury Trout 646-378-2958 rallan@soleburytrout.com
The Daily Biotech Pulse: Bausch Health Issues Positive Pre-Announcement, Acorda Streamlines Operations
The Daily Biotech Pulse: GSK, Vir To Start COVID-19 Antibody Study, Novartis In-Licenses BeiGene's Cancer Drug, Earnings Preannouncements Continue
Learn about the latest financial forecast of KLDO. Analyze the recent business situations of Kaleido Biosciences through EPS, BVPS, FPS, and other data. This information may help you make smarter investment decisions.
The average KLDO stock price target is 14.58 with a high estimate of 22.00 and a low estimate of 6.00.
-482.59K
Biotechnology & Medical Research
Pharmaceuticals & Medical Research
Chairman/Executive Director
Mike Bonney
Chairman/Director
Michael Bonney
President/Co-Founder
Geoffrey Von Maltzahn
President/Chief Executive Officer
Daniel Menichella
William Duke
General Counsel/Secretary
Jerald Korn
Johannes Van Hylckama Vlieg
Katharine Knobil
Bonnie Bassler
Grady Burnett
Clare Fisher
Theo Melas-Kyriazi
Jean Mixer
Anne Prener
8-K Kaleido Biosciences, Inc. (0001751299) (Filer)
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About KLDO
Kaleido Biosciences, Inc. is a clinical-stage healthcare company focused on leveraging the potential of the microbiome organ to treat disease and improve human health. The Company's product candidates are Microbiome Metabolic Therapies (MMTs), which are designed to modulate the metabolic output and profile of the microbiome by driving the function and distribution of the organ's existing microbes. Its proprietary product platform includes ex vivo screening of microbiome samples from healthy volunteers, ex vivo testing of patient microbiome samples and advancement of its MMT candidates into non- Investigational New Drug Application (IND) human clinical studies. Its ex vivo screening process combines advances in drug discovery with microbiome science.
Webull offers kinds of Kaleido Biosciences Inc stock information, including NASDAQ:KLDO real-time market quotes, financial reports, professional analyst ratings, in-depth charts, corporate actions, KLDO stock news, and many more online research tools to help you make informed decisions.
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How Dont'a Hightower Keyed Patriots Defensive Turnaround
New England Patriots LB Dont'a Hightower
NFL Week 9 - All throughout the offseason, the consensus belief on the New England Patriots was that their defense would return to glory and help prop up an offense littered with uncertainty. Between their approaches to free agency and the draft, as well as getting Dont'a Hightower back after he opted out last season, it was easy to understand why everyone bought into that idea.
It took a little bit of time to get there, but Bill Belichick's defense is coming together the way we all thought it would. Over the past month, the Patriots' defense has clawed its way from 11th in DVOA (good, but not enough) all the way to fifth, producing increasingly better DVOA performances week after week over that span.
Like anything, there is no one answer for the Patriots' return to defensive glory. Part of the equation is the new star power up front. Outside linebacker Matt Judon has been everything the team hoped for and more when they signed him during the free-agency period, while rookie defensive tackle Christian Barmore seems to get better every week and is on a warpath to making the All-Rookie squad. The Patriots did not have a playmaker of their caliber at either spot last season.
New England is also getting quality play from non-star players in the secondary, as they often do. Safety Adrian Phillips has continued to play well near the line of scrimmage and underneath area. Myles Bryant, a 2020 undrafted free agent, has stepped up as a sound defender and feisty tackler. With those guys holding it down as "glue" pieces while cornerback J.C. Jackson follows opponents' No.1 receivers, the secondary has really come together even with Stephon Gilmore now out of the picture.
My favorite part of any Belichick defense, however, is the linebacker play. Getting Hightower back in the lineup and back into shape as a couple of role players have stepped up has done wonders for the middle of this Patriots defense. Hightower had to knock off some rust during the early portion of the year, but with two months of play now under his belt, he has returned almost entirely to form.
The hallmark of Hightower's game is how he sees and takes on blocks. Hightower is quick to read out plays, as are all the other top linebackers, but nobody hits offensive linemen like Hightower. All 260 pounds of his frame are behind every single hit he delivers up front.
Hightower (54) effectively plays two gaps on this play. At the snap of the ball, defensive end Lawrence Guy (93) slides into the play-side B-gap (between the guard and tackle) and defensive tackle Carl Davis (98) falls back into the back-side A-gap (between the guard and center). Both the play-side A-gap and C-gap (outside the tackle) are open, the latter in part because Carolina brings a lead blocker around. Hightower flies out of his stance and pops the left guard back a step, which helps take away the A-gap before easily removing himself from the off-balance guard to work into the free C-gap.
On this rep, Hightower's effort is not as integral to the result of the play because everyone else also does their jobs, but you can see how powerful he is when taking on blocks and how much horizontal space he helps cover. Hightower again comes screaming forward right at the snap, allowing him to meet the left tackle at the line of scrimmage and knock him back a yard. The high-powered Hightower collision even helps bump Barmore (90) back into the running back and take away every inch of space. Hightower plays every rep that he can with this intensity.
And of course, Hightower is still putting in work on the edge. Hightower, Kyle Van Noy, and Jamie Collins (more on him later) have all been workable pieces on the edge for the Patriots, and it has gone a long way in keeping their defensive personnel and structure varied.
The Panthers bring a second tight end (Tommy Tremble, 82) across the formation to get a double team with some momentum on Hightower, but it does not matter. Part of that is because of how well Hightower engages with the first tight end (Ian Thomas, 80). By knocking him right off the snap, Hightower weakens the double-team effect the Panthers are aiming for because Thomas is trying to recover from the initial hit. Despite the double team, Hightower holds his ground, regains his balance after the second blocker hits him, and works horizontally while keeping his outside arm free to force the runner back inside. That kind of strength and command from both an off-ball spot and edge alignment is hard to come by.
Hightower is not the only linebacker in New England's front who brings the hammer, either. All of them do to different extents, but Hightower's primary off-ball companion, Ja'Whaun Bentley, plays like a psycho when he triggers towards the line of scrimmage and takes on blocks. Though not as heavy as Hightower, Bentley brings the same fiery energy. Offensive linemen never get an easy second-level block against this pair.
This play is nothing special, but it highlights the value in the Patriots' linebackers fitting with the speed and physicality that they do. Carolina is running duo and wants to get double teams on both the A-gap player (between the center, Sam Tecklenburg, 68, and the right guard, Trent Scott, 78) and the C-gap player (outside the tackle, Taylor Moton, 72). The whole point of duo is to hold those double teams for as long as possible and generate upfield movement, but Bentley's run fit makes that tough.
Bentley (8, the deepest defender in this clip at the snap) gets downhill in a hurry and forces the right tackle to come off the double team a tick earlier than he would probably like to. That alone is helpful, but Bentley then stands up the right tackle at the point of contact, giving the Patriots a nearly impermeable wall of defense right across the line of scrimmage. Credit to the runner for stumbling into a positive gain, but Bentley's effort took away the chance for this play to be anything more than a couple of tough-fought yards. Bentley has always kind of been capable of this, but he is doing it on a more regular basis with fewer of his chaotic plays as of late.
Along with Bentley's improved consistency, the Patriots are again getting quality play out of Collins. All of the "Collins can only perform on the Patriots" jokes are just reality at this point. So far, Collins is only earning about 15 to 20 reps per game, but he has played well on those snaps, particularly as an edge defender.
Collins (58, on the right edge) sort of gets a two-for-one with gap control on this rep, similar to Hightower in the first clip. Collins flies off the ball at the snap and crushes the tight end, giving him control of the block. From there, Collins is able to work the tight end far enough into the backfield that the edge is cut off for the running back, unless he wants to make the widest bounce to the outside of his life. While doing all of that, Collins keeps his eyes up and muscles his way back inside the moment he sees the running back is corralled and has to cut the play back up the field. Barmore (90) makes a great play of his own on the left guard and completely squeezes any potential daylight out of this run with Collins on the other side.
On top of all that muscle in the run game, the Patriots are getting decent coverage play out of their linebackers. To be clear, none of New England's linebackers have the athleticism to run with guys vertically (without jamming them) or handle quick running backs one-on-one. That is the sacrifice the Patriots make for having linebackers who can fit the run as well as they do. We even saw that with Hightower against Christian McCaffrey a couple of times in this game, including once on a deep route that was not completed thanks to Barmore knocking the pass down at the line of scrimmage. What the Patriots' linebackers can do is reroute receivers and play things out from there.
Both Hightower (54, the right inside linebacker) and Bentley (8, to Hightower's left) play this out well to different degrees. At the snap, both linebackers trigger towards the play fake, but they recognize the play is a pass before it's too late. Hightower makes a seamless transition to turn and knock wide receiver Robby Anderson (11) off his route before running across the field with him, while Bentley gets enough of tight end Ian Thomas (80) to slow him down and prevent him from sprinting past Matt Judon (9) to the flat. Pair all of that disruption in route-timing with defensive lineman Lawrence Guy (93) playing the boot effectively and you get an incomplete pass.
This time around, it is Collins getting another two-for-one. Collins (58) is playing out of the slot to the top of the screen with inside leverage on slot receiver Willie Snead (83). Collins gets a mean jam on Snead at the snap, forcing the receiver to stumble after the contact and never really open himself up to the quarterback as early as that route should be able to. After that, Collins does a good job expanding with the crossing route coming into him while gaining some depth to stay on top of it, again forcing Sam Darnold to look elsewhere and ultimately scramble.
If the Patriots are going to live in this world where their linebackers can not just run with players and play one-on-one as well as some other linebackers can, they have to be able to re-route and play with good eyes so that the rest of the coverage can fall into place. At least over the past month or so, they have been doing just that.
The Patriots will not get to completely tear apart offenses such as the Panthers every week, but keep in mind that they held the Chargers in check just a week before. That game required better pressure schemes, more thoughtful play in the back end, and a lot more press coverage in order to contain Justin Herbert—and they still handled business. Belichick knows how to put players in positions to win and the talent is there to keep this thing rolling.
If anything, the defensive line would benefit from some added consistency, but that alone should not be enough to knock the Patriots off their current trajectory. New England's defense is good enough to push them to the playoffs if the offense can give them anything more than what they currently are.
3 comments, Last at 15 Nov 2021, 4:12pm
1 Great Job
by Raiderfan // Nov 11, 2021 - 10:40am
Great analysis. I have a question, though.
"The whole point of duo is to hold those double teams for as long as possible and generate upfield movement, but Bentley's run fit makes that tough."
is this really the case? I have read—and listened to several announcers say—that the point of duo is to get an initial big push to allow one of the blockers to then move onto the second level, not hold it.
2 Great Article
by jmcpapers06 // Nov 11, 2021 - 8:32pm
Its nice to see a true football writer diving into the film, and not just the stat sheet. Hightower has to be one of the most physically imposing linebackers that I can recall.
3 Unstoppable force meets immovable object
by [Very] Special Teams // Nov 15, 2021 - 4:12pm
Neat to have features on Cleveland's O-line and NE's linebackers right before they faced off. Unstoppable force started well, but I'd say that was a win for the immovable object.


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Home > Lifestyle > Beautiful Hair With Hair Extensions – Give The Best Look To Your Hairs!
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The consensus built by the international community on the Sustainable Development Goals (SDGs) and Sustainable Development Goal 4, in particular, offers remarkable opportunities to advance the right to education and lifelong learning for all. There are undeniably several policy platforms on education that civil society and ASPBAE can engage in to advance education rights but the SDG policy framework will undoubtedly dominate the attention of governments, donors and other development stakeholders in the coming period. There is also wider recognition that all the SDGs are interconnected, therefore the argument that education is key to achieving all the SDGs is gaining traction. This presents wider opportunities for civil society to push for the right to education and lifelong learning that is embedded squarely in the efforts to end poverty and achieve social justice, gender equality, sustainable development and a lasting peace.
However, the solid promises that the SDGs and indeed what other global policy commitments hold for quality basic, youth and adult education will only be truly met if these are translated into concrete, credible, costed plans and programmes that are implemented well especially at the country level.
Governments will need to assume their roles as duty bearers, expanding and strengthening public education systems that are attentive to the SDG 4 agenda and meet their obligations to ensure the right to education of all.
CSOs need to persevere so the Education 2030 agenda is concretised, adequately resourced and well implemented faithful to the full spirit and aspirations of SDG 4 and contextualised within the current development realities of the region and respective countries.
Preserve the gains of the earlier period and ensure that the full SDG 4 agenda is pursued and implemented. Attempts to water down the agreed global consensus should be effectively challenged.
'Leaving no one behind' in education: high priority to ensuring equity, inclusion, and non-discrimination in education, expressed in defined, fully-resourced measures to reach excluded and discriminated groups, especially vulnerable women and youth.
Gender equality: while gains have been registered in gender parity in primary education, gender equality remains an outstanding challenge. It is imperative to root out the causes of inequality between women and men by addressing unequal gender relations and tackling structural barriers such as discriminatory legislation and macro-economic policies, prejudicial social norms and harmful practices, with education a major arena to combat gender injustice and inequality.
Quality education at all levels of education, including in non-formal youth and adult education. Civil society needs to challenge narrow conceptions of education quality and the regime of high stake standardised testing, whilst promoting quality education that is transformative, develops critical thinking, curiosity, creativity, and is directed at the full development of the human personality. Serious attention to filling the teaching gap with qualified, trained, motivated teachers/educators is critical to meeting the SDG 4 targets.
Promoting lifelong learning opportunities for all: Civil society will need to press for defined policies, institutional strategies and strengthened publicly funded systems for lifelong learning. This includes provision of multiple and flexible learning pathways through the whole educational system, strengthening linkages and synergies between the formal and non-formal systems of education; recognition, validation and accreditation of learnings through non-formal and informal education; strengthened delivery systems for youth and adult non-formal education such as Community Learning Centres (CLCs).
Youth and adult literacy, recognising that millions of youth and adults are still denied their right to literacy skills, with Asia being home to the largest number of these. The retreat of governments from prioritising youth and adult literacy needs to be challenged.
Skills for life and decent work, attentive to the learning needs, especially of marginalized youth and women, realizing that they are disproportionately impacted by unemployment and underemployment, with young people more than likely to be unemployed than adults and women in larger numbers suffering unemployment and vulnerable employment. Skills for life, decent work and livelihoods with dignity should be pursued in formal, non-formal, and informal settings, building clear pathways between the different education streams, valuing skills attained through experience and facilitating school to work transitions. Skills training should focus not only on work-specific skills but wider transferable skills enabling learners to be critically aware, knowledgeable about their rights, be capable of working with others and in groups, able to analyse situations, and participate meaningfully in decisions that impact their lives.
Education for Sustainable Development (ESD) and Global Citizenship Education (GCED): SDG 4.7 speaks about strengthening education's contribution in the fulfilment of human rights, peace, responsible citizenship, gender equality, sustainable development, and health. Non-formal youth and adult education are critical in equipping communities with the necessary tools – knowledge, skills, attitudes - to cope with the impacts of climate change; or growing intolerance, escalating violence,bigotry, attacks on democratic space – and the abilities to help define a more peaceful, just, sustainable development path.
To sustain advocacy for increased and better financing for the new education agenda, ensuring stronger public education systems, and check the unregulated drive for the privatisation and commercialisation of education.
Press for increased education budgets to at least 6% of the GDP and 20% of total public expenditure; and improved allocations, especially attentive to considerations of equity, inclusion and non-discrimination.
Advocate for improved domestic resource mobilisation by widening the tax base primarily through ending harmful tax incentives usually accorded to multinational companies and preventing tax evasion practices of big business enterprise.
Lobby for the adoption of regulatory frameworks and accountability mechanisms on private engagement in the education sector and counter the privatisation push in education of the private business sector and key proponents, particularly the international financial institutions and certain donors.
Advocate for increased Official Development Assistance (ODA) to close the funding gaps to meet the full SDG4 agenda, targeting countries and communities most in need.
To press for institutionalised civil society participation in national, regional/sub-regional, and global education policy spaces; with broad-based, multi-stakeholder, participatory character of SDG and SDG4 mechanisms and platforms promoted at national, regional, and global levels.
Advocacy efforts will be pursued in partnership and solidarity with other regional and global civil society networks and actors sharing common perspectives and aspirations as ASPBAE.
As part of is advocacy efforts, ASPBAE will pursue policy research, information and media work, lobbying and policy dialogue, citizens monitoring and budget tracking actions, and social mobilisation.
It will involve lobby work and engagement with UNESCO, other UN agencies, donors, and financing bodies at the regional and global levels for effective coordination and capacity-support to national governments on how to effectively translate the Education 2030 Framework for Action and SDG 4 into clear policies, strategies, indicators, guidelines and the plans to generate the resources for the full financing these require.


GREAT LAKES RADIO – In the Great Lakes region, toxic algae blooms are a big problem. Every summer, they leave a green sheen on parts of the Great Lakes – and on many smaller lakes. New York State has a new campaign to find solutions. But some question the approach.
And some of it, Boyer says, is historical. It has made its way into the soil, air and waterways, and causes fresh problems every year.
"We have seen a new phenomenon in water quality in many of our upstate lakes and alarming increase in water pollution that is dramatically affecting the quality of our lakes," he said.
These blooms pose a threat to public health across the country, and the idea is that getting everyone together will lead to creative solutions — with official action plans to be completed this spring.
"What's most important is that we understand the urgency of this issue and we move with speed and haste," he said in his speech. But some are wary of the governor's haste. Nelson Hairston, a professor of evolutionary biology at Cornell University, works with Honeoye Lake, one of New York's Finger Lakes. He's also part of the task force.
"We're interested in to what extent those nutrients come up from the sediments every summer and drive these algal blooms," Hairston says.
Scientists need more time to figure out how to remove phosphorous already in the environment, he says, because some of the fixes are very expensive and some only suppress the problem for few years.
"Is a four-year solution long enough to make everyone happy or do we want to try to do something more long-lasting?" he asks.
He says experts can learn a lot from implementing different management strategies across these 12 lakes. Then they can apply what they learn to the rest of New York's lakes — and the Great Lakes, and lakes across the country and the world.
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