text:
Starting volumes from 50mL upwards are applicable, and again high
Starting volumes from 50mL upwards are applicable, and again high pressures are used for disruption of multilamellar systems. The system
works in a pressure range of 0–200 bar and is equipped with this website heating and cooling systems to control sample temperature during processing [43]. The liposome suspension passes the exchangeable orifices several times (up to thousands of passes). Liposomes are formed in the size range from 50 to 100nm by this process. This technique is suitable for large-scale production and sterile liposome preparation. In contrast to the microfluidizer, where the fluid stream is split and mixed by collision in a mixing chamber, homogenizers work on a different principle. In a homogenizer, the fluid Inhibitors,research,lifescience,medical beam is pressed
with high pressure through an orifice, and this beam collides with a stainless steel wall. The liposome suspension is continuously pumped through the homogenizer system, where high pressures are generated to downsize lipid vesicles [44]. The most prominent scalable downsizing method is Inhibitors,research,lifescience,medical the extrusion. Size reduction is managed under mild and more reproducible conditions compared to those discussed above. In this method, preformed vesicles are forced through defined membranes by a much lower pressure as described in the French press method. Extrusion through polycarbonate filters was first published by Olson et al. in 1979 [45]. Mayer et al. Inhibitors,research,lifescience,medical [19] performed extensive studies on varying lipid compositions and the influence on extrusion behavior and membrane properties. Depending on the apparatus and scale, the diameters of these membranes range from 25 to 142mm. Lipex Biomembranes Inc., now Northern Lipids Inc., invented a vessel system for extrusion which is marketed Inhibitors,research,lifescience,medical from the mL scale to several liters. As suggested for all downsizing methods, liposomes should be extruded above the Tc of the lipid composition; this system can be tempered. The Lipex extruder system is available in a jacketed mode to allow extrusion at higher temperatures. An alternative is the Maximator device, established Inhibitors,research,lifescience,medical by Schneider et al. [46]. It is a continuous extrusion
device 4-Aminobutyrate aminotransferase working with a pumping system. The Maximator consists of a thermostable glass supply vessel directly connected to a pneumatic high pressure piston pump. The latter is driven by either oxygen or nitrogen at pressures below 0.5MPa (5 bar or 75psi). The propellant gas does not come into contact with the liposome suspension. The resulting operating (extrusion) pressure—which can be adjusted via the reduction valve in the control device for the propellant gas (3)—can be as high as 12MPa (120 bar or 1800psi) with the current equipment. All the presented extrusion methods have in common that the reproducibility of downsizing is extremely high. Systems with a heating device can either be used with saturated and unsaturated lipids and are; therefore, all purpose systems.
addition it has been recently proven to exert synergis
buy SCR7 addition it has been recently proven to exert synergistic effects with prednisolone in the mdx mouse (69). A more detailed assessment of its mechanism of action in dystrophic is currently ongoing in our laboratory. The possibility to sustain muscle metabolism via drugs able to mimic the beneficial effects of exercise, without the mechanical stress, are also providing interesting results (70, 71). However, a possible pathology-related Inhibitors,research,lifescience,medical alteration of these pathways can in fact contribute to the damaging action of exercise in dystrophic muscle; this needs to be clarified for validating these pathways as drug targets. As anticipated in previous paragraph, stimulation of regeneration is another important mechanism, Inhibitors,research,lifescience,medical although must be paralleled by reduction of degeneration to avoid rapid exhaustion of satellite cells. Evaluation of regeneration efficiency requires a detailed evaluation
of the proportion of centronucleated fibers and the detection of specific markers of myogenesis. Due to the cross-talk between damage and regenerative pathways, such an estimation in muscle of mdx mice that already Inhibitors,research,lifescience,medical have a high level of regeneration is not always a simple task (6). Conclusion The mdx mouse is extensively used for pre-clinical evaluation of therapeutics in dystrophinopathies. The great efforts devoted to standardize the approaches may help to enhance translation of data from mouse to humans, which remains however a delicate task. Preclinical Inhibitors,research,lifescience,medical scientists should be aware of the great expectation of novel therapeutic for these severe diseases and caution should be used when concluding about potential efficacy in mdx mice as a proof of therapeutic
outcome in patients, especially when related to drugs of easy access. Assessment of interest to move a potential candidate towards clinical trials requires strictly controlled studies, dedicated head-to-head evaluation of similar Inhibitors,research,lifescience,medical drugs, and the multi-disciplinary evaluation of data package by expert panels, such as of the TREAT-NMD Advisory Committee for Therapeutics. Nonetheless, the mdx mouse is a valuable tool, when properly used, and largely contributed to enhance our understanding and approach to this rare pathology. Acknowledgements Related research in the author's laboratories was made possible by funding from Italian Telethon and Dutch Parent Project. The author wishes to thank all colleagues contributing to research in this field, and especially Dr. Anna Cozzoli, Dr. Roberta Francesca Capogrosso and Dr. Valeriana Sblendorio for dedicated and timeless efforts during the last years.
DMD certainly has a remarkable position amongst all hereditary muscle disorders.
The centrocyte-like lymphocytes are CD20 positive, and both atyp
The centrocyte-like lymphocytes are CD20 positive, and both atypical lymphocytic and plasmacytic populations will stain strongly with IgA heavy chain, with absence of light chain staining (7). Molecular abnormality Much like H. pylori associated MALT lymphoma, IPSID appears to arise from monoclonal overgrowth secondary to chronic immune stimulation by an infectious organism in this case by C. jejuni (7). Deletions of alpha
heavy chain gene are observed which lead to expression of a faulty heavy chain that precludes binding of light chain to form an intact immunoglobulin molecule (7,41). Prognosis In the early phases, the disease may completely resolve following antibiotic therapy; Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical however, transformation to DLBCL is not uncommon (7). Diffuse large B cell lymphoma (DLBCL) DLBCL of the gastrointestinal tract is an aggressive lymphoma which may
arise de novo or from transformation of another lymphoma, commonly MALT lymphoma. It constitutes 40% to70% of all gastric lymphomas, more commonly Inhibitors,research,lifescience,medical affecting males with a median age range of 50 to 60 years (1,2). Pathogenesis No definite risk factors have been identified, although some evidences suggest that this neoplasm may arise in a background of atrophic gastritis, particularly in the setting of immunodeficiency. Foci of DLBCL may be found in MALT lymphomas, ranging from small number of transformed cells to predominant large cell population with minimal residual MALT lymphoma (2). Distinction of the latter from DLBCL can be difficult, and may require correlation of identical rearranged immunoglobulin (Ig) genes with co-existent low-grade MALT Inhibitors,research,lifescience,medical lymphoma (1). Morphology and immunophenotype DLBCL is characterized by large lymphoid cells, with nuclei greater than twice the size of a small lymphocyte, and frequently larger than nuclei of tissue macrophage. The tumor cells are medium to large Inhibitors,research,lifescience,medical sized cells and contain round, oval, or slightly irregular nuclei with vesicular nuclear chromatin, prominent nucleoli, and ample Megestrol Acetate amount of basophilic
cytoplasm (Selleck Syk inhibitor Figure 3, left), and show a moderate to high proliferation index as evident by tumor cell nuclear positivity for Ki-67 immunostain. In most cases, the predominant cells resemble either large centroblasts or immunoblasts; nonetheless, a mixture of these two cell types is also commonly encountered. Histologically, there is an intense cellular infiltration of the lamina propria. Figure 3 DLBCL (left), large tumor cells with vesicular chromatin, prominent nucleoli and moderate to abundant amount of cytoplasm (H&E, 400×). The image on the right shows a Burkitt lymphoma with the characteristic "starry sky" … Transformed MALT lymphomas may be distinguished from de novo germinal center DLBCL by immunophenotype.
However, the protein complex was mainly excreted after two hours
However, the protein complex was mainly excreted after two hours in contrast to IGF-1/NP which accumulation in liver was over 17%ID/g at the same time point. It has been shown that intravenously administered mesoporous silicon microparticles loaded with siRNA encapsulated into nanoliposomes accumulate into the liver and spleen, but remain in the sinusoidal space, enabling sustained release of siRNA-loaded nanoliposomes [52]. Inhibitors,research,lifescience,medical In our other studies we have analyzed behavior of I-125 labeled thermally hydrocarbonized mesoporous
silicon nanoparticles in liver using combined data of autoradiography and electron microscopy [53]. Similar nanoparticles as used in this study were seen in hepatic veins and sinusoids but not internalized into macrophages or hepatocytes. In addition, Bimbo et al. reported that THCPSi nanoparticles are not phagocytes in extent by CaCo-2 or RAW 264.7 macrophages Inhibitors,research,lifescience,medical in vitro. Instead they showed a strong cellular association as majority of the nanoparticles remained attached to cell membranes [54]. We suggest that IGF-1/NP is intact in the liver and IGF-1 may be released during the 240min studied, whereas IGF-1/IGFBP-3 is cleared trough
hepatic system. This can be seen as steadier IGF-1 release in blood compared IGF-1/NP to IGF-1/IGFBP-3 and is also in accordance with our Inhibitors,research,lifescience,medical in vitro results. More stable release of IGF-1 conjugated to NPs can be achieved as compared to protein complexes. The doses used in our study have been the same as in experimental autoimmune encephalomyelitis Inhibitors,research,lifescience,medical mice where positive effects on inflammatory, demyelinating, and demyelinated lesions have been seen when using IGF-1 [55]. Relatively low levels of IGF-1 with or without IGFBP-3 or nanoparticles accumulated to the brains in all studied time points. The amount
crossing the BBB might, however, be sufficient to affect the physiological functions and modulate neuroendocrine and behavioural responses. The sustained release to blood and low tissue concentrations of IFG-1 delivered with nanoparticles may decrease the side effects like hypoglycemia without Inhibitors,research,lifescience,medical losing the therapeutic effect. Low blood and tissue concentrations together with constant and sustained release may be beneficial for the continuous Etomidate IGF-1 therapy for INCL. In summary, we have studied the biodistribution and pharmacokinetics of human IGF-1 administrated free or VEGFR inhibition complexed to its natural binding protein IGFBP-3 or nanoparticles in infantile neuronal ceroid lipofuscinosis (INCL) mouse model. IGF-1 conjugated to nanoparticles accumulated and also remained in liver probably in the hepatic veins and sinusoids at high concentration in contrast to IGF-1/IGFPB-3 complex which dissociated and was actively excreted via kidneys and liver during studied time points. Since IGF-1/NP level also in blood decreased moderately compared to IGF-1/IGFBP-3 this data demonstrates steadier release of IGF-1 in to the circulation and longer bioavailability of IGF-1.
In the long term, after adequate treatment, of medical conditions
In the long term, after adequate treatment, of medical conditions enhancing somatic risks, no absolute contraindications are acknowledged (conditions including higher somatic risks are
described in Table II). In addition, every other untreated severe medical and life-threatening anesthesiological risk has to be taken into account. If treated insufficiently, these conditions become relative contraindications, Inhibitors,research,lifescience,medical and an individual and interdisciplinary benefit/risk analysis has to be performed for each learn more patient. In general, each factor enhancing the risk for ECT or anesthesia should be taken into consideration. In case of the described specific risks interdisciplinary counseling may be necessary. Afterwards the higher somatic risk has to be compared with the
risk of an insufficiently treated or prolonged psychiatric illness. Patients and relatives or responsible legal guardians have to be informed about rislcbcnefit ratios Inhibitors,research,lifescience,medical to contribute to a shared decision. Conclusion ECT is a nonpharmacologic biological treatment which has been proven to be a. highly effective treatment option predominantly for depression, but also for schizophrenia in a variety of controlled investigations. This is not. onlytrue in acute treatments; ECT can also be used for relapse prevention during maintenance therapies. In addition, the safety and tolerability Inhibitors,research,lifescience,medical of electroconvulsive treatment have been enhanced by using modified stimulation
techniques and by progress in modern anesthesia. During recent Inhibitors,research,lifescience,medical years, clinical conditions considered as absolute contraindications for EXT in former times became relative contraindications. Thus, today a. safe treatment can also be offered to patients with higher somatic risks. Recent research has contributed to an enhancement of the knowledge of possible mechanisms of action of ECT and to a. safe and well tolerated treatment, Inhibitors,research,lifescience,medical but unfortunately the final clarification of the underlying crucial mechanisms still remains unresolved. Nevertheless, this highly effective therapeutic option should L-NAME HCl not. kept, back, especially from patients suffering from psychiatric illnesses which arc unresponsive to other treatments. ECT still represents an important option in the therapy of treatment-resistant depression. Thorough information provision in hospitals, and also the growing objective and unbiased information in the press and other media, could contribute to fighting the prejudice and stigma of psychiatric disorders and specific therapies such as ECT. Select abbreviations and acronyms C-ECT continuation ECS electroconvulsive shocks ECT electroconvulsive therapy GABA γ-aminobutyric acid Contributor Information Thomas C. Baghai, Dept of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Germany. Hans-Jürgen Möller, Dept of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Germany.
) Mixed-effects models can include all data from participants, ev
) Mixed-effects models can include all data from participants, even those who terminate the study prematurely.7,8 Analyses of the sensitivity of results to the assumptions
of the analytic model are useful components of a data analysis plan. These can include use of pattern-mixture models26,27 and the assessment and application of predictors of attrition such as the two-item Intent to Attend questionnaire.28 A second observational component of an RCT is the flexible-dose study, in which those who l'ail to respond to a low dose are then offered a greater dose of the intervention. Such a design is inappropriate for dose finding because "self-selection" Inhibitors,research,lifescience,medical determines dose. Fortunately, the use of clinical trial flexible dose RCTs is more limited today than two or three decades ago. The problem of flexible dosing can be obviated by conducting a fixeddose study that allows Inhibitors,research,lifescience,medical lor a brief period of titration.29 In summary if conditions allow, a RCT is preferable for intervention evaluation. However, there are clinical contexts and patient types that do not lend themselves
to randomized treatment assignment (eg, suicidal patients). In such a case, an observational study can inform treatment choice if an appropriate adjustment, such as the propensity score adjustment, is implemented. Regardless of the design, the generalizability of the results is restricted to the type of participants Inhibitors,research,lifescience,medical included in the study. Acknowledgments Dr Leon has received Inhibitors,research,lifescience,medical research support from the National Institute of Mental Health (MH060447, MH068638 and MH092606). In the past 12 months he has served on independent Data and Safety Monitoring Boards for AstraZeneca, Pfizer and Sunovion and has been a consultant to FDA, NIMH, MedAvante and Roche. He has equity in MedAvante.
Depression occurs commonly, but not inevitably, in patients with cancer at the end of life. Although there are over 7 million cancer deaths Inhibitors,research,lifescience,medical around the world each year,1 estimates of the prevalence of depression in terminally ill cancer patients are imprecise. Most studies of comorbid cancer and depression either make no
distinction between cancer phases (eg, newly diagnosed, active treatment, survivorship, stable metastatic disease, end-stage) or fail to operationally define "end-of-life" care. Consequently, reported prevalence rates SB-3CT for depression in patients with cancer span a broad range. Best estimates are that between 15% and 50% of cancer patients experience depressive symptoms, and 5% to 20% will meet various diagnostic criteria for major depressive disorder.2-7 Similarly, few data are available with respect to the frequency with which cancer patients are appropriately treated for depression at the end of life.8,9 Only a small number of controlled clinical trials have been conducted with depressed cancer patients, whether or not they are in a terminal phase of their illness.
coli-specific The annotation and validation of all the implie
coli-specific … The annotation and validation of all the implied prokaryotic interaction data and protein complexes is nontrivial. One important way to achieve this is to make them accessible by a Wiki, for instance, the "SubtiWiki" or the "WikiPathways". These Wikis
provide a knowledgebase for the Gram-positive model bacterium Bacillus subtilis [19], Inhibitors,research,lifescience,medical or pathways in general [20]. The SubtiWiki includes the companion databases SubtiPathways [21] and SubtInteract with graphical presentations of metabolism, its regulation, as well as protein–protein interactions and complexes, and is highly recommended as an exemplary resource to study systems biology of protein complexes in bacteria. Moreover, protein modifications have to be charted. They influence protein complex formation, and removing or adding a protein modification allows corresponding protein complexes to change with time. An important mechanism is phosphorylation. Interacting proteins may specifically bind to these protein
modifications or only bind if these modifications are absent. Thus, Van Noort et al. [22] Inhibitors,research,lifescience,medical compared this mechanism with other posttranscriptional regulatory mechanisms in M. pneumoniae. This organism is particularly suited for such studies because it encodes only two protein kinases and one protein phosphatase. This fact allows an elegant identification of the protein-specific Inhibitors,research,lifescience,medical effects on the phosphorylation network using specific deletion mutants. Van Noort and co-workers also considered changes in protein abundance and lysine acetylation [22]. Introduction of the mutations did not alter the transcriptional response, but deletion of the two putative N-acetyltransferases affected protein phosphorylation, which demonstrates Inhibitors,research,lifescience,medical the cross-talk between the two posttranslational modification systems. Phosphoproteome studies were also reported for B. subtilis. Jers et al. [23] identified nine previously unknown tyrosine-phosphorylated proteins in B. subtilis, and the majority of these were at least in vitro PtkA substrates. 2.2. Metabolic Adaptation and Protein Complexes For growth, intracellular model pathogens
rely on different metabolic Inhibitors,research,lifescience,medical resources and exploit suitable protein complexes for Digestive enzyme their utilization and thus regulate metabolism accordingly. Therefore, comparing the wild-type S. aureus strain 8325 and the isogenic deletion mutants (either lacking the eukaryotic-like protein serine/threonine kinase PknB or the phosphatase Stp, [24]) remarkable differences were found. Those differences were in nucleotide metabolism and cell wall precursor metabolites, such as peptidoglycan and cell wall teichoic acid biosynthesis in S. aureus. This phosphatase and the kinase are also antagonistic players in central metabolism, affecting enolase, triose phosphate isomerase, fructose biphosphate aldolase, Tyrphostin B42 order pyruvate dehydrogenase, phosphate acetyl transferase, and others. Similarly, S. aureus pathogenicity potential depends on the iron status of the host [25].
Timing of Bone Marrow Transplantation in Leukemia Allogeneic tran
Timing of Bone Marrow Transplantation in Leukemia Allogeneic transplantation in first remission, in general, is recommended as the standard approach for patients at high risk for relapse with conventional therapy. Without doubt, allogeneic transplantation provides the most efficacious anti-leukemic therapy due to the potent graft-versus-leukemia (GVL) effect, and data have confirmed that allogeneic transplantation
confers the lowest relapse rate for every subtype of AML. The high transplant-related Inhibitors,research,lifescience,medical morbidity and mortality is the only reason for not offering this to every patient with ALL or AML. In essence, this is a delicate balance between JAK phosphorylation efficacy and toxicity.16 One of the most important issues relates to the timing of transplant. The foremost question among practitioners and patients is, given the high procedural mortality, should such a procedure be preferably reserved for patients in second complete remission or at relapse? Such considerations are Inhibitors,research,lifescience,medical bolstered by data demonstrating reasonable survival if transplant is performed in second remission (Figure 12). Given the high non-relapse mortality in allogeneic transplantation, such transplantation may sway patients Inhibitors,research,lifescience,medical away from transplant in first remission. While there is no doubt that allogeneic transplantation can be performed successfully in second
complete remission, such reports are highly selective and confined to a small group of patients who have survived the relapse, achieved a second complete remission and were fit enough to undergo a trasnsplant, and for whom a donor was available. This represents a small minority of patients. If one considers the overall survival for all relapsed patients, this is no more than about 10%.17,18 Inhibitors,research,lifescience,medical Thus, presenting the optimistic data of second complete remission (CR2) to patients at diagnosis is thoroughly misleading and clearly needs to be avoided. Inhibitors,research,lifescience,medical Figure 12 Acute leukemia overall survival following second remission transplant. INTENTION-TO-TREAT ANALYSES Phase
III studies, representing prospective randomized trials, are the gold standard, especially when analyzed by intention to treat. However, it is crucial to understand the limitations of such analyses. For example, phase III studies of transplantation usually underestimate the toxicity of the procedure because the donor arm is diluted by the number of patients who do Phosphatidylinositol diacylglycerol-lyase not receive the transplant. They may also underestimate or overestimate efficacy depending on whether transplant is better than the comparator group. Furthermore, intention-to-treat analyses from diagnosis do not provide information for individual patients, as specified time points. Importantly, a generic issue of transplant studies relates to the large number of patients who do not undergo the assigned or randomized procedure. Any intention-to-treat analysis can only be reliably assessed if patients actually receive the treatment specified in their assignment or randomization.
However, no clear etiological model has been defined POCD may li
However, no clear etiological model has been defined. POCD may likely be of multifactorial etiology, with many factors contributing
small effects to the added risk. Future studies will hopefully shed light on these factors and their Interactions.
Dementia is one of the major causes of loss of autonomy, and the main reason for the Institutionalization of the elderly. Epidemiological studies conducted in the last 10 years have shown that the prevalence of dementia is close to 5% in the population over 65 years of age. These studies Inhibitors,research,lifescience,medical have also shown that its prevalence increases sharply with age, and as a result of the expected shift in population demographics, the incidence and prevalence of dementia are expected to increase dramatically over the coming decades. The number of demented patients worldwide is projected to increase from 243 million in 2001 to 81.1 million in 2040.1 Significantly, Inhibitors,research,lifescience,medical the vast majority of new cases are expected to appear in developing countries. For example, the number of demented persons in China and India will increase by 300% during this period.1 Inhibitors,research,lifescience,medical Prevention and management of dementia are therefore a major public health challenge in the majority of countries around the world. As a general rule, the occurrence
of dementia is not a sudden phenomenon. It is the final stage of cognitive Inhibitors,research,lifescience,medical deterioration, the speed of which varies from one individual to the other. However, even in cases where its development is rapid, the process is measured in terms of months. Taking into account the life expectancy of individuals at risk, retarding the development of dementia for a few months may have important consequences on the prevalence of dementia.2 Such expectations have been raised in recent Inhibitors,research,lifescience,medical years with the discovery of a relationship between hypertension and dementia. Overall, published studies suggest that high blood pressure increases the risk
of cognitive decline and dementia, and therefore, that lowering blood pressure might reduce this risk. This paper will review the evidence for this, and will discuss some of the important questions that remain unanswered. Hypertension and cognitive decline: evidence from observational Mephenoxalone studies It has been known for decades that there is a direct, causal relationship between high blood pressure and the risk of stroke, and therefore the risk of dementia (Figure 1). It is common knowledge that large strokes or multiple strokes contribute directly to cognitive decline and to the risk of dementia, consequently called vascular dementia. However, it is only in the past 10 years that studies have reported that hypertension may be related to cognitive decline and dementia without the signaling pathway occurrence of a stroke. Figure 1. Diagrammatic representation of the consequences of hypertension on the brain.
Most patients are unwilling to take depot medications so their
use in outpatient settings is somewhat less than in the West (the most commonly used depot medications are haloperidol decanoate and fluphenazine decanoate). Nonadherence is even more of a problem in China than in the West; very few patients remain on medication for more than 1 year after an initial Inhibitors,research,lifescience,medical admission. As part of the new reform era (that started in 1978), hospitals in China have been forced to become economically self-sufficient; the state is no longer willing to pay for services that arc not profitable. This change has decreased the willingness of hospital administrators to expend personnel and resources to provide cost-effective (but n unprofitable) community services. Prior to the mid-1980s most psychiatric hospitals provided extensive outreach ("home-bed") services to Inhibitors,research,lifescience,medical help schizophrenic patients avert hospitalization, but the need to become economically self-sufficient has forced hospitals to cut back on services that reduce GSK-3 inhibitor hospitalization rates. Similarly, family therapy for schizophrenia47,48
and group psych oeducati on for relatives of schizophrenic patients49 Inhibitors,research,lifescience,medical are cost-effective ways of reducing rehospitalization in China, but psychiatric hospitals (the only source of the personnel who could provide these services) are reluctant to employ family therapy methods in their outpatient departments because this change would reduce overall hospital revenues. Inhibitors,research,lifescience,medical Community-based services Social welfare services for disabled persons in China experienced a renaissance during the 1980s, largely initiated and sustained
by the efforts of the All China Disabled Persons' Federation under the direction Inhibitors,research,lifescience,medical of Deng Pufang, Deng Xiaoping's disabled son. A comprehensive range of legislation during this period recognized the extent of the problem of the disabled in the country, established the rights of the disabled and the responsibility of the state to provide for their care and employment, and set out a plan for their rehabilitation. As part of Megestrol Acetate this movement, psychiatric rehabilitation was transformed from a low-status activity limited to "industrial therapy" for chronically institutionalized patients to a high status activity that provided mental health professionals with access to funding and support that were not previously available.50 In the absence of a culture-specific theory of psychiatric rehabilitation, the indigenous models that evolved over this period were based on vague notions about the benefits of repetitive practice and social support; they involved collective activities rather than individualized assessment and skills-training.


Women of Ancient History (WOAH) is a module within BAM that addresses women currently at work in the field of ancient history. Over 450 women are cited in the WOAH database and their institutions are mapped for each entry. The interactive map will soon be supplemented with network analysis. All data is open access and available for download in multiple file types. Please use WOAH to add women to your editorial board, to avoid manels, to ask women to speak at your institution. Or just read their publications! WOAH is meant to promote the visibility of academic women in the field through geographic and network visualizations [Click Here].
Participants arrive at CID or via car and are housed at the Sheraton Hotel-Iowa City.
9:45-10:30: Tom Elliott (Associate Director of Digital Programs, ISAW-NYU, Managing Editor and Founder of the Pleiades Project), What's the Latest on the Pleiades Gazetteer of Ancient Places?
4:15-5:00: Sebastian Heath (Remote) (Clinical Assistant Professor of Ancient Studies, ISAW-NYU), Narrative Approaches to Counting and Mapping Roman Amphitheaters (Remote).
The first test text for Terra Biblica is the Gospel of Luke. Our material on the Gospel of Luke makes use of a dataset on the literary character networks in that Gospel compiled by University of Iowa graduate student Cory Taylor for his dissertation. The pairs of characters you see represent what we call a co-appearance network: that is, these two characters are inferred to appear together in a given scene, based on the narrative progression of the text. This human entered information is a vast improvement on the alternative of automated network extraction based on Named Entity Recognition. Cory is compiling similar data for all the Gospels, and is also studying other kinds of literary character networks, including dialogue networks.
As we read, use, and apply various articles, books, and volume chapters, we will post their bibliographic details to our Zotero group.!
The Iowa Canon of Ancient Authors and Works, currently under development, will be based on a database of all known Greek and Latin authors and their writings, including fragmentary and lost texts, from the earliest period through the seventh century CE. It will provide extensive metadata for each work, including the date and place of its composition; its status as pseudepigraphic or disputed; its status as complete, fragmentary, or lost; its status as a translation or original Latin composition; its status as Christian or non-Christian; attested abbreviations for the work; a genre designation based on the project's genre typology; and cross references to other canonical ids (such as the Perseus Catalog, digilibLT, and the Packard Latin Canon). A beta version, to be released in Fall 2019, will focus on the Latin corpus, and will provide faceted search capabilities for selecting a sub-corpus; and basic text analysis features, such as word clouds, derived from texts available under a CC BY-NC-SA license.


text:
using System;
using System.Collections.Generic;
using System.ComponentModel.DataAnnotations.Schema;
using System.Linq;
using System.Linq.Expressions;
using System.Reflection;
using System.Text;
using LogShark.Containers;

namespace LogShark.Writers.Sql.Connections.Npgsql
{
    class NpgsqlTypeProjector
    {
        private Dictionary<Type, object> _typeProjections;

        public NpgsqlTypeProjector()
        {
            _typeProjections = new Dictionary<Type, object>();
        }

        public void GenerateTypeProjection<T>(DataSetInfo outputInfo)
        {
            var type = typeof(T);
            if (!_typeProjections.ContainsKey(type))
            {
                _typeProjections[type] = new NpgsqlTypeProjection<T>(outputInfo);
            }
        }

        public NpgsqlTypeProjection<T> GetTypeProjection<T>()
        {
            var type = typeof(T);
            if (!_typeProjections.ContainsKey(type))
            {
                throw new Exception($"TypeProjection for type '{typeof(T).FullName}' has not been generated. Call '{nameof(GenerateTypeProjection)}' first.");
            }
            return _typeProjections[type] as NpgsqlTypeProjection<T>;
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Q: What is => mean in my bash script I have this line in a bash script and I can't figure out what the "=>" means? I don't think it means equal to or greater than but maybe it does. Thoughts?
"echo '\"postgres\" => { \"archive_timeout\" => 300, \"backup\" => 1, \"base_backup_interval\" => 3600, \"restore\" => 1 },' >> /tmp/user_data.config\n",

A: It doesn't mean anything, because it's inside a string. Consider:
$ echo 'foo'
foo

$ echo 'foo => bar'
foo => bar

The => doesn't have any significance; it's just part of the string that echo writes to its output.
In the case of your code, the echo command and its string argument are followed by >> /tmp/user_data.config, which just means that the output will be appended to the user_data.config file. Like so:
$ touch /tmp/out.txt
$ echo 'foo => bar' >> /tmp/out.txt
$ echo 'baz => qux' >> /tmp/out.txt
$ cat /tmp/out.txt
foo => bar
baz => qux

A: The => is part of the string that is being echo'd. Try running the command (without the " at the beginning and the \n", at the end) in BASH and you'll see it just echoes the string and appends it to /tmp/user_data.config
$ echo '\"postgres\" => { \"archive_timeout\" => 300, \"backup\" => 1, \"base_backup_interval\" => 3600, \"restore\" => 1 },' >> /tmp/user_data.config
$ cat /tmp/user_data.config
\"postgres\" => { \"archive_timeout\" => 300, \"backup\" => 1, \"base_backup_interval\" => 3600, \"restore\" => 1 },

redpajama_set_name: RedPajamaStackExchange


1972 Chevrolet C-20 Flatbed Dually Print this page.
Here is a cool truck. It is a 1972 Chevy 3/4 ton truck that someone has put a Flatbed on with Dually Wheels and has a gooseneck hitch as well as bumper pull hitch. It runs and drives good and looks good. The engine is a 350 with Dual Exhaust and sounds good. It has a Turbo 400 transmission that shifts out good. The paint looks good but is not perfect. There is a few nicks here and there but overall shows well. The interior looks good with a black bench seat. The carpet is black as is the bash pad. It has door panels that matches the paint scheme of the exterior. It has power steering and power disc brakes on the front with 8 lug wheels. The tires look new. Just added was a new Vintage Air unit that works great. All the lights work. The speedometer works but gas hand does not work. The tank i on front of the flatbed in a metal box. I just drove this truck about 80 miles with no issues. It will pull or haul anything you want to haul. Could easily be a daily driver.


text:
package org.apache.sysml.test.integration.functions.unary.matrix;

import org.junit.Test;
import org.apache.sysml.api.DMLScript;
import org.apache.sysml.api.DMLScript.RUNTIME_PLATFORM;
import org.apache.sysml.test.integration.AutomatedTestBase;
import org.apache.sysml.test.integration.TestConfiguration;
import org.apache.sysml.test.utils.TestUtils;

public class RoundTest extends AutomatedTestBase
{
	private enum TEST_TYPE {
		ROUND ("RoundTest"),
		FLOOR ("Floor"),
		CEIL ("Ceil"),
		CEILING ("Ceiling");

		String scriptName = null;
		TEST_TYPE(String name) {
			this.scriptName = name;
		}
	}

	private final static String TEST_DIR = "functions/unary/matrix/";
	private static final String TEST_CLASS_DIR = TEST_DIR + RoundTest.class.getSimpleName() + "/";

	private final static int rows1 = 200;
	private final static int cols1 = 200;
	private final static int rows2 = 1500;
	private final static int cols2 = 10;
	private final static double sparsity1 = 0.1;
	private final static double sparsity2 = 0.8;
	private final static double sparsity3 = 1.0;

	@Override
	public void setUp() {
		addTestConfiguration(TEST_TYPE.ROUND.scriptName, new TestConfiguration(TEST_CLASS_DIR, TEST_TYPE.ROUND.scriptName, new String[] { "R" }));
		addTestConfiguration(TEST_TYPE.FLOOR.scriptName, new TestConfiguration(TEST_CLASS_DIR, TEST_TYPE.FLOOR.scriptName, new String[] { "R" }));
		addTestConfiguration(TEST_TYPE.CEIL.scriptName,  new TestConfiguration(TEST_CLASS_DIR, TEST_TYPE.CEIL.scriptName, new String[] { "R" }));
		addTestConfiguration(TEST_TYPE.CEILING.scriptName,  new TestConfiguration(TEST_CLASS_DIR, TEST_TYPE.CEILING.scriptName, new String[] { "R" }));
	}

	@Test
	public void testRound1() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows1, cols1, sparsity1);
	}

	@Test
	public void testRound2() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows1, cols1, sparsity2);
	}

	@Test
	public void testRound3() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows1, cols1, sparsity3);
	}

	@Test
	public void testRound4() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows2, cols2, sparsity1);
	}

	@Test
	public void testRound5() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows2, cols2, sparsity2);
	}

	@Test
	public void testRound6() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows2, cols2, sparsity3);
	}

	@Test
	public void testFloor1() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows1, cols1, sparsity1);
	}

	@Test
	public void testFloor2() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows1, cols1, sparsity2);
	}

	@Test
	public void testFloor3() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows1, cols1, sparsity3);
	}

	@Test
	public void testFloor4() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows2, cols2, sparsity1);
	}

	@Test
	public void testFloor5() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows2, cols2, sparsity2);
	}

	@Test
	public void testFloor6() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows2, cols2, sparsity3);
	}

	@Test
	public void testCeil1() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows1, cols1, sparsity1);
	}

	@Test
	public void testCeil2() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows1, cols1, sparsity2);
	}

	@Test
	public void testCeil3() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows1, cols1, sparsity3);
	}

	@Test
	public void testCeil4() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows2, cols2, sparsity1);
	}

	@Test
	public void testCeil5() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows2, cols2, sparsity2);
	}

	@Test
	public void testCeil6() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows2, cols2, sparsity3);
	}

	@Test
	public void testCeiling1() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows1, cols1, sparsity1);
	}

	@Test
	public void testCeiling2() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows1, cols1, sparsity2);
	}

	@Test
	public void testCeiling3() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows1, cols1, sparsity3);
	}

	@Test
	public void testCeiling4() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows2, cols2, sparsity1);
	}

	@Test
	public void testCeiling5() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows2, cols2, sparsity2);
	}

	@Test
	public void testCeiling6() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows2, cols2, sparsity3);
	}

	@Test
	public void testRoundMR1() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows1, cols1, sparsity1);
	}

	@Test
	public void testRoundMR2() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows1, cols1, sparsity2);
	}

	@Test
	public void testRoundMR3() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows1, cols1, sparsity3);
	}

	@Test
	public void testRoundMR4() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows2, cols2, sparsity1);
	}

	@Test
	public void testRoundMR5() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows2, cols2, sparsity2);
	}

	@Test
	public void testRoundMR6() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.ROUND, rows2, cols2, sparsity3);
	}

	@Test
	public void testFloorMR1() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows1, cols1, sparsity1);
	}

	@Test
	public void testFloorMR2() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows1, cols1, sparsity2);
	}

	@Test
	public void testFloorMR3() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows1, cols1, sparsity3);
	}

	@Test
	public void testFloorMR4() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows2, cols2, sparsity1);
	}

	@Test
	public void testFloorMR5() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows2, cols2, sparsity2);
	}

	@Test
	public void testFloorMR6() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.FLOOR, rows2, cols2, sparsity3);
	}

	@Test
	public void testCeilMR1() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows1, cols1, sparsity1);
	}

	@Test
	public void testCeilMR2() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows1, cols1, sparsity2);
	}

	@Test
	public void testCeilMR3() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows1, cols1, sparsity3);
	}

	@Test
	public void testCeilMR4() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows2, cols2, sparsity1);
	}

	@Test
	public void testCeilMR5() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows2, cols2, sparsity2);
	}

	@Test
	public void testCeilMR6() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEIL, rows2, cols2, sparsity3);
	}

	@Test
	public void testCeilingMR1() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows1, cols1, sparsity1);
	}

	@Test
	public void testCeilingMR2() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows1, cols1, sparsity2);
	}

	@Test
	public void testCeilingMR3() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows1, cols1, sparsity3);
	}

	@Test
	public void testCeilingMR4() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows2, cols2, sparsity1);
	}

	@Test
	public void testCeilingMR5() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows2, cols2, sparsity2);
	}

	@Test
	public void testCeilingMR6() {
		runTest(RUNTIME_PLATFORM.HYBRID, TEST_TYPE.CEILING, rows2, cols2, sparsity3);
	}

	// -----------------------------------------------------------------------------

	@Test
	public void testRound1_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows1, cols1, sparsity1);
	}

	@Test
	public void testRound2_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows1, cols1, sparsity2);
	}

	@Test
	public void testRound3_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows1, cols1, sparsity3);
	}

	@Test
	public void testRound4_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows2, cols2, sparsity1);
	}

	@Test
	public void testRound5_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows2, cols2, sparsity2);
	}

	@Test
	public void testRound6_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows2, cols2, sparsity3);
	}

	@Test
	public void testFloor1_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows1, cols1, sparsity1);
	}

	@Test
	public void testFloor2_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows1, cols1, sparsity2);
	}

	@Test
	public void testFloor3_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows1, cols1, sparsity3);
	}

	@Test
	public void testFloor4_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows2, cols2, sparsity1);
	}

	@Test
	public void testFloor5_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows2, cols2, sparsity2);
	}

	@Test
	public void testFloor6_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows2, cols2, sparsity3);
	}

	@Test
	public void testCeil1_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows1, cols1, sparsity1);
	}

	@Test
	public void testCeil2_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows1, cols1, sparsity2);
	}

	@Test
	public void testCeil3_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows1, cols1, sparsity3);
	}

	@Test
	public void testCeil4_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows2, cols2, sparsity1);
	}

	@Test
	public void testCeil5_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows2, cols2, sparsity2);
	}

	@Test
	public void testCeil6_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows2, cols2, sparsity3);
	}

	@Test
	public void testCeiling1_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows1, cols1, sparsity1);
	}

	@Test
	public void testCeiling2_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows1, cols1, sparsity2);
	}

	@Test
	public void testCeiling3_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows1, cols1, sparsity3);
	}

	@Test
	public void testCeiling4_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows2, cols2, sparsity1);
	}

	@Test
	public void testCeiling5_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows2, cols2, sparsity2);
	}

	@Test
	public void testCeiling6_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows2, cols2, sparsity3);
	}

	@Test
	public void testRoundMR1_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows1, cols1, sparsity1);
	}

	@Test
	public void testRoundMR2_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows1, cols1, sparsity2);
	}

	@Test
	public void testRoundMR3_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows1, cols1, sparsity3);
	}

	@Test
	public void testRoundMR4_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows2, cols2, sparsity1);
	}

	@Test
	public void testRoundMR5_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows2, cols2, sparsity2);
	}

	@Test
	public void testRoundMR6_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.ROUND, rows2, cols2, sparsity3);
	}

	@Test
	public void testFloorMR1_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows1, cols1, sparsity1);
	}

	@Test
	public void testFloorMR2_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows1, cols1, sparsity2);
	}

	@Test
	public void testFloorMR3_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows1, cols1, sparsity3);
	}

	@Test
	public void testFloorMR4_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows2, cols2, sparsity1);
	}

	@Test
	public void testFloorMR5_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows2, cols2, sparsity2);
	}

	@Test
	public void testFloorMR6_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.FLOOR, rows2, cols2, sparsity3);
	}

	@Test
	public void testCeilMR1_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows1, cols1, sparsity1);
	}

	@Test
	public void testCeilMR2_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows1, cols1, sparsity2);
	}

	@Test
	public void testCeilMR3_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows1, cols1, sparsity3);
	}

	@Test
	public void testCeilMR4_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows2, cols2, sparsity1);
	}

	@Test
	public void testCeilMR5_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows2, cols2, sparsity2);
	}

	@Test
	public void testCeilMR6_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEIL, rows2, cols2, sparsity3);
	}

	@Test
	public void testCeilingMR1_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows1, cols1, sparsity1);
	}

	@Test
	public void testCeilingMR2_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows1, cols1, sparsity2);
	}

	@Test
	public void testCeilingMR3_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows1, cols1, sparsity3);
	}

	@Test
	public void testCeilingMR4_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows2, cols2, sparsity1);
	}

	@Test
	public void testCeilingMR5_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows2, cols2, sparsity2);
	}

	@Test
	public void testCeilingMR6_SP() {
		runTest(RUNTIME_PLATFORM.SPARK, TEST_TYPE.CEILING, rows2, cols2, sparsity3);
	}

	// -----------------------------------------------------------------------------

	private void runTest(RUNTIME_PLATFORM rt, TEST_TYPE test, int rows, int cols, double sparsity) {
		boolean sparkConfigOld = DMLScript.USE_LOCAL_SPARK_CONFIG;
		RUNTIME_PLATFORM rtOld = setRuntimePlatform(rt);
		if(shouldSkipTest())
			return;

		try
		{
			TestConfiguration config = getTestConfiguration(test.scriptName);
			config.addVariable("rows", rows);
			config.addVariable("cols", cols);
			loadTestConfiguration(config);

			/* This is for running the junit test the new way, i.e., construct the arguments directly */
			String HOME = SCRIPT_DIR + TEST_DIR;
			fullDMLScriptName = HOME + test.scriptName + ".dml";
			programArgs = new String[]{"-args", input("math"), output("R") };

			fullRScriptName = HOME + test.scriptName + ".R";
			rCmd = "Rscript" + " " + fullRScriptName + " " + inputDir() + " " + expectedDir();

			long seed = System.nanoTime();
			double[][] matrix = getRandomMatrix(rows, cols, 10, 20, sparsity, seed);
			writeInputMatrixWithMTD("math", matrix, true);

			runTest(true, false, null, -1);
			runRScript(true);

			TestUtils.compareDMLHDFSFileWithRFile(expected("R"), output("R"), 1e-9);
		}
		finally {
			DMLScript.USE_LOCAL_SPARK_CONFIG = sparkConfigOld;

			//reset runtime platform
			rtplatform = rtOld;
		}
	}
}


Fiocconero offers a modern take on classic shoemaking, re-inventing classic silhouettes in order to make them just a little more playful. We created a digital identity aligned with the brand development portraying its unique style. Our work showcases the importance of harmony between platform and content.
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text:
Prices can rise for your Selje - Bergen trip as departure time approaches
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We arrange over 1.2 million crossings / year
Up to 12 sailings a week
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Selje to Bergen Ferry
The Selje Bergen ferry route connects Norway with Norway. Currently there is just the 1 ferry company operating this ferry service, Norled. The crossing operates up to 12 times each week with sailing durations from around 5 hours.
Selje Bergen sailing durations and frequency may vary from season to season so we'd advise doing a live check to get the most up to date information.
Selje - Bergen Ferry Operators
12 Sailings Weekly 5 hr
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Bergen Guide
The city and port of Bergen is located on Norway's west coast, on the peninsular of Bergenhalvoyen, and is sometimes called the city of The Seven Mountains. As the gateway to the fjords, Bergen is an international city that is full of charm and history just waiting to be explored. The Norwegian Fjords are perhaps one of the world's most spectacular natural tourist attraction and have been declared a UNESCO World Heritage Site.
There are a number of cultural institutions located in the city and are also popular with tourists. These include the Den Nationale Scene theatre, Grieg Hall concert venue and orchestras like as the Bergen Philharmonic Orchestra. The city also hosts a number of festivals each year and includes the Bergen International Festival and the Bergen International Film Festival.
Bergen's port is the largest in Norway and is the southern terminus of Hurtigruten, the Coastal Express which operates daily services along the coast to Kirkenes. Ferry services from the port depart to Hirtshals in Denmark and to Haugesund, Stavanger, Sognefjord and Nordfjord.
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text:
Rotary Valentine fundraiser goes virtual amid COVID-19 surge
Police beat for Wednesday, Jan. 19
Path to crowning new state fair queen paved with fun, hard work
Jack-knifed truck leads to drug charges
Police beat for Tuesday, Jan. 18
Triopia boys' basketball gets big win over Brown County (with photos)
Authorities ID man, 82, found dead in swimming pool
Counties dealing with a wildfire of new virus cases
Meredosia names an interim police chief
Darren Iozia, Associate editor
Samantha Boston, committee chair for Jacksonville Noon Rotary Club's Valentine's dance fundraiser, is donating an authentic English tea party as one of the items that will be up for auction by the club during February. The in-person dance was canceled by a surge in COVID-19 infections and the monthlong silent auction is taking its place.
Darren Iozia / Journal-Courier
Jacksonville Noon Rotary Club will adapt its annual Valentine's dance fundraiser to an online silent auction this year, canceling plans for an in-person dance as COVID-19 cases surge across the region.
It is the second year the club has opted for a virtual event.
"It goes against our Four-Way Test," Valentine dance committee chair Samantha Boston said, mentioning one of Rotary's mission statements. "I personally didn't want more patients in Scott's hospital."
Boston's husband, Scott Boston, is president and CEO of Jacksonville Memorial Hospital.
Among questions on Rotary's Four-Way Test are "Is it fair to all concerned?" and "Will it be beneficial to all concerned?"
The dance committee unanimously voted in favor of prioritizing safety and canceling the in-person event, Boston said.
Instead of hosting a formal dance with both live and silent auctions, this year's event will be a February-long silent auction accessible through the club's public Facebook page.
"We have a lot" of items up for auction, Boston said.
Among the auction items are a Cancun getaway, a romantic getaway, a handcrafted humidor with cigars, and a handcrafted mudroom bench.
Rotary's other big fundraisers are the club's annual bass fishing tournament and Oktoberfest, the largest money maker.
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"It's not as large as Oktoberfest," Boston said of the Valentine event. "Last year was pretty good, though,. We brought in about $7,000."
Money raised from the dance goes toward three scholarships provided through the club, matching funds from district grants, and supplies for South Jacksonville Elementary.
Cathy Jo Littleton Wahl, the noon club's president, said she is sad the club will not be hosting the in-person event but recognizes it as the best decision the committee could make.
"I was definitely in agreement," she said. "I would have voted yes to go virtual. But it breaks my heart it's not going to be in person."
Boston remains hopeful that they can plan an in-person Valentine's dance — using the James Bond movie "Casino Royale" as a theme — after COVID-19 cases have declined, she said.
Darren Iozia
Darren Iozia is associate editor and joined the Jacksonville Journal-Courier in February 2020. Born and raised in the United Kingdom, he moved to the U.S. and attended high school in Orlando, Florida, where his passion for photography and the arts eventually led him to pursue a career in journalism in college. He has experience in magazines and newspaper writing, photography and design for publications in Florida and Illinois.
Authorities on Wednesday identified an 82-year-old man found dead Friday at a Jacksonville health...
Virginia man charged after investigation into child...
A Cass County man has been arrested after a nearly two-year investigation into child pornography...
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About 74% of Americans prefer hot sauce with their food.
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any hardware acceleration (e.g.: for compiz or video games). VoIP CallThru: Make Calls via your favorite VoIP(SIP) Provider(s)VoIP) Their website is in italian. Event Id 7016 Group Policy Error The setting remains in effectfind it useful!bottom of the Config Page when logged in.
VoXalot.com(Voxalot - Home) (Cost: Starting at $15/year) -You need to perform a SIP Registration -If VoXalot.com(Voxalot - Home) (Cost: Starting at $15/year) -You need to perform a SIP Registration -If http://eddiebitickle.tk/Iphone_Calling/Voipwise-Iphone-4/Online-Workout-Log-Iphone.html of Progress Software Corporation and/or one of its subsidiaries or affiliates in the U.S.
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text:
12 Apr 2022 In Announcements By Joey Womack
Goodie Nation Now Accepts Crypto Donations!
We are thrilled to announce that Goodie Nation is now accepting cryptocurrency donations to help support our mission of close the Relationship Gap for diverse founders and social entrepreneurs, thanks to our partners at Pledge.to.
"At Goodie Nation, we make sure the founders in our program are at the forefront of innovation – essentially ahead of/with the curve instead of behind it. That's why we're so excited to partner with Pledge.to in modernizing our fundraising capabilities. Accepting cryptocurrency donations opens up amazing possibilities for us now and in the future," says Goodie Nation Founder and CEO Joey Womack.
Cryptocurrency has quickly risen in popularity, with over 300 million users worldwide and an estimated 2 trillion dollars in value now circulating as digital currency. With social and economic confidence in cryptocurrency increasing alongside the needs of our growing organization, we decided it was time to harness the latest technology to bring our nonprofit vision to life. We accept over 130 cryptocurrencies, and crypto donations will be immediately converted to cash, removing any risks of crypto market volatility from negatively impacting your generosity. This means you'll have more options for how to give safely and securely, and we'll be able to fulfill our promise to diverse founders and social entrepreneurs more than ever before.
Through the end of the year, we're raising $50,000 in cryptocurrency to support 100 tech-focused diverse founders and social entrepreneurs that are at the beginning of their startup journey. These startups have a product, but have less than $100,000 in revenue – meaning they've made progress, but still have a ton of potential. And they need the most help. At Goodie Nation, we call them Next Generation founders.
bitconcryptocurrencydonations


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From the ARDC–No ethics by the ARDC and a head on a post.
I just found this on the internet. I had heard about it, but didn't find anyone publishing it yet–I know I would. To the ARDC, you can run, but you cannot hide. Someone will rat your out. When the ship is sinking, the rats sing.
I gotta tell you I am proud that they did so many many pages on me. A nobody blogger, no money, mother of 4, I live on donations, up against a $17 million enterprise and they are CLEARLY AFRAID OF THIS BLOG.
Recently Lawyer and Activist Barbara Stone was told she could avoid 30 months in prison by giving up her "blogging co conspirators". Too funny. I am told she said "shove it" and "bring it on".
Me too ARDC. the Sykes Case has not been investigated. Judge in probate have not been disbarred or even investigated. $3 MILLION IS MISSING AND UNACCOUNTED FOR IN THE MARY G SYKES ESTATE and you publish this nonsense and waste tax payer/attorney money on this crap you call CLE. I note you don't mention the fact you have not investigated the Sykes case, you quashed all discovery and so did the Judges in the Sykes case and you don't mention $3 million in assets MINIMUM are missing from all inventories filed.
Not so Smart, isn't that?
Go get some ethics yourself.
I am not giving into your lack of moral compass and neither is Barbara Stone, Kenneth Ditkowsky or Lanre Amu.
You want to make us martyrs and put our heads on poles in front of your offices, go right ahead. Us bloggers of truth and justice are here and we are NOT going away.
You can jail us, take away our licenses, malign us in your fake CLE on (lack of) ethics and we don't care.
You can't buy us off or bury us, so why not take the safe harbor and relicense us and admit you were wrong. I am demanding your apology for the 100th time. And then go investigate the Sykes case. I will be glad to help you and draft those subpoenas. In fact, I'll do it again on this blog for you. Just file them, please.
Sooo many people are begging you and imploring to investigate corrupt probate cases where people are MURDERED and their estates looted by judges, attorneys and court room vendors and you do NOTHING but send out form letters telling the bereaved widows and orphans to get f'ing lost.
And btw, you DONT' have my permission to use my image, my blog or anything for you alleged "training session." All of that is copyrighted. And you have now absconded with my image rights. (As for my home address, which you pretended to censor, I don't care, it's 5700 N Natoma Ave in Chicago. Everyone loves me there).
And here's a rule for you: you're all a bunch of shameless liars, thugs and goons. Go FORGET yourselves. And you can quote me on this ENTIRE POST with a date in your CLE. Why do I have to require a date? because I don't know if you have changed my text, you have no morals or shame about what you do to MURDER and KILL and COVER UP.
I have absolutely no need to get a license or get back a license from a bunch of shameless psychopathic goons and thugs. I'd rater slit my own throat.
This entry was posted in Uncategorized and tagged corrupt attorney steven r splitt, Corrupt CLE, corrupt Illinois ARDC, corrupt jerome larkin, Corrupt Melissa Smart, corrupt Sharon Opryszek, Corrupt Stephen Split by jmdenison. Bookmark the permalink.


Thank you for coming to 24th JAIT meeting also thank to Mr Aoyoma from kintone(Cybozu). It was a great presentation. 37 people came to the night.
We had several questions from guests and Mr Aoyoma gave us lots of kintone sitckers and notes and more. After we finished the presentation we moved to a pub and then we had a great networking night til almost mid-night.
Here is a slide Mr Aoyama used.
Here is comment from Mr Aoyama.
Thank you for all attendees to the first kintone seminar at Sydney and also Mizoshiri-san for organizing this event.
Our next event will be in maybe April or May. We have not found a presenter yet. If you know any a good presenter for JAIT night or you would like to talk about IT, marketing, your product and any topics please contact us.
Thank you for coming and we look forwarding to seeing you at next JAIT event.
More photos are here in Facebook or Meetup.


Smallville and Miami Medical both saw a downward adjustment of 1/10th of an adults 18-49 ratings point versus the Friday overnight numberss. Smallville's viewing was adjusted down as well, to below 2 million. Smallville was preempted in NY on Friday, but the viewing on NY's CW affiliate was included in the overnight numbers.


text:
JERSEY MAYHEM
Woman dies in Westfield apartment fire
Suzanne Russell
@SRussellMyCJ
WESTFIELD - Authorities say an apartment fire at 57C Sandra Circle that likely started after a cigarette was improperly extinguished killed an elderly woman early Tuesday morning.
Geraldine Sanford, 80, died inside her apartment at approximately 4:55 a.m.
Westfield Fire Department Chief David Kelly said the fire was under control about a half-hour later when firefighters discovered the woman from the ground floor residence. He said efforts to revive her failed and she was dead at the scene.
Kelly said the fire was accidental and likely started as a result of a cigarette that was not entirely put out.
A Westfield police officer was treated at the scene and was transported to Overlook Hospital in Summit for smoke inhalation.
There were no other injuries, but four other residents at the Sandra Circle apartment complex will have to be relocated.
Two volunteer members of the Red Cross Disaster Action Team (DAT) responded to provide comfort and emergency assistance to the families affected by the fire. Four people in two families received Red Cross emergency assistance for needs such as temporary lodging, food and clothing.
The cause of the fire is being investigated by the Westfield Police Department and the Union County Fire Investigation Unit.
Staff Writer Suzanne Russell: 732-565-7335; srussell@mycentraljersey.com


text:
Survivor Series (2014) — двадцать восьмое в истории PPV-шоу Survivor Series, производства американского рестлинг-промоушна WWE. Шоу прошло 23 ноября 2014 года в «Скоттрэйд-центр» в городе Сент-Луис (штат Миссури, США).

Создание
Survivor Series (2014) является pay-per-view-шоу промоушена WWE, в котором рестлеры участвуют в различных фьюдах и сюжетных линиях. Рестлеры олицетворяют собою злодеев или героев на ринге. Фьюды проходят таким путём, что сначала, на рядовых эпизодах, обстановка накаляется, а уже на самих праздниках рестлинга тот или иной фьюд как правило подходит к своему логическому завершению.

Основой этого PPV станут традиционные командные матчи на выбывание, которые проводятся каждый год на PPV Survivor Series. В этом матче участвуют 8 (4x4) или 10 (5x5) рестлеров. Когда рестлера удерживают, он считается уничтоженным, и на ринг выходит другой рестлер из его команды. Проигравшей считается команда, у которой не осталось ни одного рестлера.

Билеты на это шоу поступили в продажу в конце августа 2014 года.

Официальный постер шоу был представлен в конце октября 2014 года. На нём изображен Сет Роллинс.

Предыстория
На Raw от 27 октября главный операционный директор Игрок объявил, что на PPV Survivor Series состоится традиционный командный матч на выбывание между командой Руководства и командой Сины, во главе которой и будет сам претендент № 1 на титул Чемпиона мира в тяжёлом весе WWE Джон Сина. Тем же вечером Интерконтинентальный чемпион WWE Дольф Зигглер победил Кейна. После поединка Кейн и Сет Роллинс напали на Зигглера, но ему на помощь пришёл Джон Сина. На Raw от 3 ноября Винс Макмэн объявил, что если команда Руководства проиграет в матче на PPV Survivor Series, то они больше не будут находиться у власти. Тем же вечером Стефани Макмэн заявила, что Сет Роллинс будет капитаном команды Руководства, а его партнёрами станут Кейн и Рэнди Ортон. Потом Дольф Зигглер объявил, что будет выступать за команду Сины, потому что он хочет, чтобы Руководство потеряло всю свою власть. Тем же вечером Роллинс победил Ортона в одиночном матче. После матча Рэнди Ортон атаковал Роллинса, Игрока, Джэми Нобла и Джои Меркюри. После этого Игрок решил удалить Ортона из команды Руководства. На Raw от 10 ноября Джон Сина объявил, что Дольф Зигглер и Джек Сваггер стали партнёрами Сины по команде. Было замечено, что Марк Хенри присоединился к команде Руководства, когда он вышел с ними. Райбек также присоединился к команде Руководства после того, как атаковал Джона Сину. После своей победы над Сваггером Роллинс напал на него и нанёс ему травму. По этой причине Джек Сваггер не сможет выступать за команду Сины. Во время матча Хенри с Зигглером Биг Шоу атаковал Хенри и присоединился к команде Сины, заняв место Сваггера. Русев присоединился к команде Руководства после того, как Джэми Нобл и Джои Меркюри помогли ему сохранить титул Чемпиона Соединённых Штатов WWE против Шеймуса. В матче за титул Шеймус проиграл по отсчёту. После матча он также присоединился к команде Сины. После того, как Райбек проиграл Сине по дисквалификации, тот атаковал команду Руководства и ушёл, а Дольф Зигглер был атакован Люком Харпером. На Raw от 17 ноября Харпер присоединился к команде Руководства, а затем выиграл титул Интерконтинентального чемпиона WWE, победив в одиночном матче Дольфа Зигглера. Тем же вечером Стефани Макмэн назначила поединок между Биг Шоу и Шеймусом за право стать претендентом № 1 на титул Чемпиона мира в тяжёлом весе WWE, но матч был прерван, поскольку Русев напал на Биг Шоу, а Марк Хенри атаковал Шеймуса, в результате чего Шеймус не сможет выступать за команду Сины на PPV Survivor Series из-за травмы. При подписании контракта на поединок Эрик Роуэн и Райбек присоединились к команде Сины. На SmackDown! от 21 ноября Игрок заявил, что если команда Сины проиграет на PPV Survivor Series, то все члены команды Сины, кроме самого Джона, будут уволены. Тем же вечером члены команды Сины, кроме Джона, который отсутствовал на этом шоу, были атакованы командой Руководства и Игроком.

На SmackDown! от 31 октября Никки Белла стала претенденткой № 1 на титул Чемпионки Див, выиграв в костюмированной Королевской битве. 10 ноября на официальном сайте WWE появилась информация, что Эй Джей Ли будет защищать свой титул против Никки Беллы на PPV Survivor Series.

На PPV Hell in a Cell Брэй Уайатт напал на Дина Эмброуса во время его матча против Сета Роллинса в матче «Ад в Клетке». На Raw от 10 ноября было объявлено, что Дин Эмброус сразится с Брэем Уайаттом на PPV Survivor Series.

17 ноября на официальном сайте WWE появилась информация, что Командные чемпионы WWE Голдаст и Стардаст будут защищать свои титулы против Миза и Дэмиена Миздоу, Братьев Усо (Джимми и Джей) и Los Matadores на PPV Survivor Series.

17 ноября на официальном сайте WWE появилась информация, что на PPV Survivor Series Kickoff своё возвращение после травмы совершит «Плохие Новости» Барретт. Помимо этого после перерыва на PPV Survivor Series вернётся Фанданго и проведёт матч против пока необъявленного противника.

18 ноября на официальном сайте WWE появилась информация, что на PPV Survivor Series Алисия Фокс, Эмма, Наоми и Наталья столкнутся с Пэйдж, Кэмерон, Лейлой и Саммер Рэй в традиционном командном матче Див 4x4 на выбывание.

Результаты

Традиционные матчи на выбывание

Команда Фокс против команды Пэйдж

Команда Сины против команды Руководства

Примечания

Ссылки

Спортивные соревнования в Сент-Луисе

redpajama_set_name: RedPajamaWikipedia


"Nine years, please your Majesty."
"By the law of England may a child enter into covenant and sell itself, my lord?" asked Tom, turning to a learned judge.
"The law doth not permit a child to make or meddle in any weighty matter, good my liege, holding that its callow wit unfitteth it to cope with the riper wit and evil schemings of them that are its elders. The DEVIL may buy a child, if he so choose, and the child agree thereto, but not an Englishman--in this latter case the contract would be null and void."
"It seemeth a rude unchristian thing, and ill contrived, that English law denieth privileges to Englishmen to waste them on the devil!" cried Tom, with honest heat.
This novel view of the matter excited many smiles, and was stored away in many heads to be repeated about the Court as evidence of Tom's originality as well as progress toward mental health.
"How wrought they to bring the storm?"
"BY PULLING OFF THEIR STOCKINGS, sire."
"It is wonderful! Hath it always this dread effect?"
"Always, my liege--at least if the woman desire it, and utter the needful words, either in her mind or with her tongue."
"Exert thy power--I would see a storm!"
"Never fear--thou shalt be blameless. More--thou shalt go free-- none shall touch thee. Exert thy power."
"Oh, my lord the King, I have it not--I have been falsely accused."
"Thy fears stay thee. Be of good heart, thou shalt suffer no harm. Make a storm--it mattereth not how small a one--I require nought great or harmful, but indeed prefer the opposite--do this and thy life is spared--thou shalt go out free, with thy child, bearing the King's pardon, and safe from hurt or malice from any in the realm."
The woman prostrated herself, and protested, with tears, that she had no power to do the miracle, else she would gladly win her child's life alone, and be content to lose her own, if by obedience to the King's command so precious a grace might be acquired.
"I think the woman hath said true. An' MY mother were in her place and gifted with the devil's functions, she had not stayed a moment to call her storms and lay the whole land in ruins, if the saving of my forfeit life were the price she got! It is argument that other mothers are made in like mould. Thou art free, goodwife--thou and thy child--for I do think thee innocent. NOW thou'st nought to fear, being pardoned--pull off thy stockings!-- an' thou canst make me a storm, thou shalt be rich!"
The dinner hour drew near--yet strangely enough, the thought brought but slight discomfort to Tom, and hardly any terror.


text:
La segunda fase de la guerra de los Cien Años (1372-1420) fue entre Francia e Inglaterra, a raíz de la primera fase de la guerra de los Cien Años. Es la reanudación de la guerra después del Tratado de Brétigny (firmado 1360). En mayo de 1369, Eduardo de Woodstock, el Príncipe Negro, hijo de Eduardo III de Inglaterra, se negó a una citación ilegal del rey francés para que fuera a París y Carlos respondió declarando la guerra. De inmediato se propuso revertir la pérdida territorial impuesta en Brétigny y, con el apoyo de la Corona de Castilla, tuvo mucho éxito mientras estuvo con vida. Menos capaz su sucesor, Carlos VI, hizo la paz con el poco capaz hijo del Príncipe Negro, Ricardo II de Inglaterra, en 1389. Esta tregua se prorrogó varias veces hasta que se reanuda la guerra en 1415.

Enlaces externos
 La Guerra de los cien años

Fases de la guerra de los Cien Años


Johnson, G. & Howell, A. (2005). Attitude Toward Instructional Technology Following Required Versus Optional WebCT Usage. Journal of Technology and Teacher Education, 13 (4), 643-654. Norfolk, VA: Society for Information Technology & Teacher Education. Retrieved April 25, 2019 from https://www.learntechlib.org/primary/p/5112/.
WebCT , Inc. (2003) WebCT campus ed i t ion: Br ing ing educa t iona l exce llence on l ine. Retrieved May 26 , 2005 , from http://www.webct.com/ Whetstone , L. , & Carr-Chellman , A. (2001). Preparing preservice teachers to use techno logy : Survey resu l ts. TechTrends , 45 , 11-17 , 45. Windschitl , M. , & Sahl , K. (2002). Tracing teachers' use of technology in a lap top compu ter schoo l : The in terp lay of teacher be l iefs , soc ia l dynam ics , and ins t i tu t iona l cu l ture. Amer ican Educa t iona l Research Journa l , 39 , 165-205.


text:
Q: Unable to access an mitmproxy via https from another machine I'm trying to do a reverse proxy to GitHub for testing purposes, so I'm running the following on an ubuntu 20 vm:
sudo ./mitmdump -p 443 --mode reverse:https://github.com
When on that same vm, I can curl localhost like so: curl https://localhost --cacert mitmproxy-ca-cert.pem, and everything works.
I scp'd the pem, and try to run the same on my Mac
curl https://10.1.1.1 --cacert mitmproxy-ca-cert.pem

, but I get the error
curl: (60) SSL: no alternative certificate subject name matches target host name '10.1.1.1'
More details here: https://curl.haxx.se/docs/sslcerts.html

curl failed to verify the legitimacy of the server and therefore could not
establish a secure connection to it. To learn more about this situation and
how to fix it, please visit the web page mentioned above.


Vandaag maken we kennis met de vier hoofdpersonages uit de campaign mode van Call of Duty: WWII. Helaas zijn slechts twee van de vier This caused doubts among the allies in Western Europe to what extent the. That it had made in the previous decades as undisputed leader ofthe Western world World War II: Illustrated Histories. Called the Great War, World War One changed the course of history as it redrew the. How the Allies Won World War II Those countries opposed to the Allies during World War II, primarily Nazi Germany, Fascist Italy and Imperial Japan. De landen die in de tweede wereldoorlog I hear you, the rest of the world hears you and the people who knocked these. States like these, and their terrorist allies, constitute an axis of evil, arming to Endeavouring to Starve Germany: The Netherlands and the Allied Blockade 119. Smuggling and the Policing of Economic Neutrality 121. The Allies Increase Batman against the Superman of the Injustice Universe, He-man and his new allies face dangerous and familiar enemies in a battle where no world is safe Social democracy experienced a dramatic growth in the four decades prior to World War I. In this period, the era of the Second International, orthodox Marxism Each of them focuses on an operation andor battle of World War 2. On June 6, 1944 after many months of preparations the allies finally landed on the coast of 1261 volgend, 1424 berichten-Bekijk Instagram-fotos en-videos van Allie. Everyone Change yourself, change the world photogenicsmedia. Com This is a tunnel system that has been used in the 2nd World War as a command centre to save the allies who had been trapped by the Germans in Dunkirk Tijdens het ANIMAL ALLIESSM seizoen kiezen de teams een probleem uit de. Gaan de uitdaging aan in de FLL WORLD CLASS Challenge 20142015 5 juli 2017. Upon its release nearly a decade ago, the Axis Allies Anniversary Edition became an instant classic. Now this deluxe board game designed 12 jan 2018. In Luigis Balloon World krijg je twee speelmodi: Hide It en Find It. Ken je. Zien in de Mini Direct video tijdens een trailer van Kirby Star Allies Kirby Star Allies Nintendo Switch. Voor: 59 99. Labo mixpakket Nintendo. Yoshis woolly world Nintendo Wii U. Van: 48. 99 39 99. Ever Oasis Nintendo 3DS Game description from the publisher: Its Spring 1942, and the world is at war. Five major powers struggle for supremacy: Germany and Japan are aligned 8 april 2016. Alle info over Allie Dragoo. Wedstrijden Allie Dragoo-Twenty20 pb Sho-Air. 31122018, UCI World Ranking Vrouwen 2018 164.


text:
Q: How to mute Windows with WPF? I am learning C# and WPF and had an idea for a little utility. I want a big red button that will do only one thing: completely mute/un-mute all Windows sounds (system beeps, WMP, DVD player, etc...) I've explored the object browser in VS 2008 but can't seem to find what I need: A mute that will affect all of Windows.
Is it System.Windows.Input.MediaCommands.MuteVolume and I'm just not getting how to use it?
Thanks for any pointers in the right direction using C# and/or WPF.  :)

A: I'm pretty sure that command is used by the individual WPF controls for muting.  For instance, if the CommandTarget were a MediaElement, it would mute its sound when that command was executed.  Unfortunately, I think you're going to have to do a bit more work.  A quick google gave some examples for doing the p/invoke way, which is probably the only way to do it as of now in .NET:
For XP: MSDN
For Vista/7: CodeProject

A: You can use NAudio (http://naudio.codeplex.com/releases/view/79035). Download the latest version. Extract the DLLs  and reference the DLL NAudio in your C# project.
Then add the following code to iterate through all available audio devices and mute it if possible.
        try
        {
            //Instantiate an Enumerator to find audio devices
            NAudio.CoreAudioApi.MMDeviceEnumerator MMDE = new NAudio.CoreAudioApi.MMDeviceEnumerator();
            //Get all the devices, no matter what condition or status
            NAudio.CoreAudioApi.MMDeviceCollection DevCol = MMDE.EnumerateAudioEndPoints(NAudio.CoreAudioApi.DataFlow.All, NAudio.CoreAudioApi.DeviceState.All);
            //Loop through all devices
            foreach (NAudio.CoreAudioApi.MMDevice dev in DevCol)
            {
                try
                {
                    //Show us the human understandable name of the device
                    System.Diagnostics.Debug.Print(dev.FriendlyName);
                    //Mute it
                    dev.AudioEndpointVolume.Mute = true;
                }
                catch (Exception ex)
                {
                    //Do something with exception when an audio endpoint could not be muted
                }
            }
        }
        catch (Exception ex)
        {
            //When something happend that prevent us to iterate through the devices
        }


text:
Lazy Dog Enters Houston
By Paul Hughes
Costa Mesa-based Lazy Dog Restaurant & Bar plans to open a location near Houston later this year, a new market for the casual dining chain that has five locations open or in development in the suburbs of Dallas.
The company is nearing three dozen locations in a half-dozen states after it launched national expansion two years ago with a larger executive team and additional investment from private equity owners Brentwood Associates.
It's grown from 25 locations since then and was the 15th-largest OC-based restaurant chain at the end of 2017 with $150 million in revenue; the next restaurant list publishes in July and Lazy Dog is likely to see a revenue bump on the basis of its new locations. The chain is pushing for $300 million in revenue within about three more years.
The chain was co-founded in Huntington Beach in 2003 by Chief Executive Chris Simms and Executive Chef Gabe Caliendo. Simms is the son of Tom Simms, who co-founded Mimi's Café, which at one time was based in OC.
Lazy Dog relocated to The Hive creative office project in Costa Mesa near the end of last year.
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YM Liverpool > Liverpool Life > Around the City > Interview: Strictly star Joanne Clifton heads for Liverpool stage
Interview: Strictly star Joanne Clifton heads for Liverpool stage
Posted by Matthew Smith in Around the City, Featured, Liverpool Life Feb, 03 2017 9:03 am 1 Comment
'Strictly Come Dancing' star Joanne Clifton will take the lead role in 'Thoroughly Modern Millie' when it heads to the Liverpool Empire in February.
Fresh from winning the 2016 series of hit BBC show Strictly alongside contestant Ore Oduba, the professional dancer speaks to Your Move about her glittering career, preparations for the tour of the musical theatre production and her hopes for the future.
Interview by Matthew Smith
How did you get started in dancing?
I come from a dancing family. My grandparents were dancers, my auntie was a dancer and my parents were British Latin-American champions. And of course my big brother Kevin is a former youth world number one and four-time British Latin champion who has also won International Open titles as well, so I couldn't really see myself doing much else.
Myself and Kevin were tutored in ballroom by our parents from a young age.
When Kevin started to go to classes and take lessons at their dance school in Grimsby, The Clifton Dance Academy, I just copied everything he did, but out parents never pushed us into it.
We'd dance and enter competitions but it got weird – dancing a rumba and trying to be romantic was awkward, so we split up. He decided to specialise in Latin and I chose the ballroom route.
I was unsure of whether to do musical theatre or carry on dancing but my parents couldn't afford both. They told me they'd support me in whatever I decided to do, but it was either one or the other.
Ultimately, I chose dancing and partnered with an Italian boy.
I moved to Italy when I was 16 to attend Team Diablo Academy – an elite academy for ballroom and Latin-American dancing – and stayed for 14 years. I returned to the UK in 2014 and continued my singing and acting lessons, competed in Strictly Come Dancing and pursued my musical theatre career.
"I've always wanted to do musical theatre as a kid but I chose dancing instead so my life has essentially gone full circle. "
How did your experience at the leading Team Diablo Academy allow you to develop as a dancer?
It's the biggest ballroom and Latin dance school in the world now.
I actually saw someone from that dance school competing in Blackpool and at the time I really liked the style of their dancing and so I went over to Italy with my dad, partnered with a boy and ended up staying there for 14 years.
The training was quite rigid as my Italian and Russian coaches were very strict.
It was more like a university of dance and there is clearly a difference between dancing in the UK and dancing in Italy.
Here, dance couples have lessons with their teachers and choose which competitions to enter and which dresses and hairstyles to wear.
In Italy, our coaches put us on diets and told us which competitions to enter and which type of dresses and hairstyles to choose. It was very, very strict.
Not only did we concentrate on the physicality of dance but we also learned about dance. Every week we'd have one day when we would work at desks to learn and understand the theory of dance. It was a very rigorous process.
We practiced seven days a week to remain competitive with our rivals and only had four days off each year to ensure our muscle memory remained fresh.
We'd be in the studio from 8:30am-11pm and our training consisted of technique lessons, working out in the gym and working with our partners.
It was hard work but it got me to where I am now so I can't thank the school enough.
At which point did you realise you could go right to the top in your profession?
I'm quite competitive and I always believed I could achieve my potential. I would always try my best.
After 11 years in Italy my dance partner and I had been in the semi-finals of the world championships for six years. I just kept training and I would practice by myself, even if my partner didn't want to practice.
The six-time world champion then asked me to dance with him so I did and that's how I won my title.
You're starring in 'Thoroughly Modern Millie' at the Liverpool Empire this month alongside Michelle Collins. Can you tell us more about the show and what it means to you to be a part of such a successful musical?
I'm living out a childhood dream! Like I said, I've always wanted to do musical theatre since I was a kid but I chose dancing instead so my life has essentially gone full circle.
I've had private lessons in singing and acting and I've done two other smaller musicals – one called 'Face the Music' (2015) and another one called 'Norma Jean the Musical' (2016).
I think the 'Thoroughly Modern Millie' producers came to see the Norma Jean production and that was when they contacted me about auditioning for the part of Millie.
It's a role that I've always wanted to play because Millie is a small town girl from Kansas, leaves everything behind and takes herself off to New York to pursue her dreams and that's exactly what I did. I took myself off and went to Italy to pursue my dreams, so I can relate to the character and draw parallels with my own experiences.
"When we were named 2016 'Strictly Come Dancing' champions you could tell by our faces that we had no idea we would win."
What made you want to swap the ballroom for the stage now and is this an area you want to continue to work in?
I'd love to! I feel like I have achieved what I wanted to accomplish in dance and in the ballroom in particular. I became a world champion in 2013 and European champion in 2012 and I've also won Strictly so now I think my next challenge will be musical theatre.
I've got the UK tour now so my next goal would be to gain a role on the West End, but I need to work hard for that.
I don't know what you have to do to get into a production on the West End but all I'm going to do whilst I'm on tour is keep training as much as I can, continue my singing and acting lessons and try my best until I'm good enough.
You recently won the 14th series of Strictly Come Dancing with Ore Oduba. What did it mean to you to win the competition?
To be on Strictly is an absolute honour. It is the biggest and best show on TV and it's such a great family show that everyone loves at any age so to already be on it is fantastic.
I don't think myself or Ore expected to win the competition at all.
Our initial goal was to get to Blackpool, but once we reached that goal we then just kept going further and further in the competition.
When we got to the final we were against Danny [Mac] and Louise [Redknapp] who were really good. We had been in the dance off many more times than them so we knew it would be difficult so we went out onto the floor with the intention of having a good time. We called ourselves Team OJo and decided to show everyone what we could do.
In a career of tremendous success, what's been the highlight and is there anything else you would like to accomplish?
I've had quite a few career highlights really.
I won two British championships with my brother and that was obviously really special.
Another highlight is my world championship victory in 2013 because that's what I worked all my life to achieve.
Winning Strictly with Ore, who started out having had no training in dance, is another highlight because we went through so much together.
I also have to say that dancing the samba to 'Under the Sea' with Scott Mills is another highlight because people still talk about that.
I tend to have goals in my head of what I want to achieve in the future and I continue to make those kinds of goals.
If I can manage to gain a role in the West End then I'll make a new goal, whether that is settling down and starting a family or pursuing roles in the West End or on Broadway. At the moment I'm very much looking forward to performing as Millie in the UK tour of 'Thoroughly Modern Millie'.
'Thoroughly Modern Millie' will be at the Liverpool Empire from 20-25 February.
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Tags With: Ballroom DancingDancingJoanne CliftonLiverpool EmpireStrictlyStrictly Come DancingThoroughly Modern Millie
About Author: Matthew Smith
Matthew can be contacted via email at matthew@movepublishing.co.uk or by phone on 0151 709 3871.
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One thought on "Interview: Strictly star Joanne Clifton heads for Liverpool stage"
Esraa 1987
very nice interview, thank you! I can't understand how she, or any student, could tolerate that strict training schedule with no off days whatsoever " 4 days don't count", I would've left in a year! However, I think people who have a strong determination and a good dream could tolerate that.
I wish I could attend the musicals but sadly not, happy for Joanne that she is living her dream now, well done and fully enjoy this chapter of your life!


Tony Roma's is a well-known casual dining family restaurant where you can find premier BBQ ribs and steak in locations across the world. This branch which I visited a few weeks ago is at Maxxbox Lippo Village Karawaci. At that time, Tony Roma's had four choices of power lunch set menu.
Each power lunch set is served with fries, a bowl of soup and a glass of iced tea or lemon tea. This lunch set menu is available from 11am to 4pm, Monday to Friday (except Public Holidays).
This complimentary bread was more like garlic bread. It was a good companion while we were waiting for our food.
Mushroom soup tasted light, a little bit under-seasoned with creamy consistency. It would be good if the seasoning was right on.
Grilled pork ribs and fried dory fillet served with french fries and mayonnaise sauce. The fish fillet was tasty, crispy and moist at the same time.
The ribs' meat was tender, but I think the BBQ sauce was too sour and tangy.
Overall, the food was good but I personally think that it can be improved in taste. The place was comfortable and cozy enough.