text:
Tetanus Vaccine: Composition, Mechanism of Action, Dosage, Side Effects, Contraindications and Interactions
This disease is a serious bacterial infection that causes painful muscle spasms and can lead to death.
Composition of the tetanus vaccine
Mechanism of action of the tetanus vaccine
Diphtheria, tetanus, pertussis, hepatitis B, polio, haemophilus influenzae type b, for children under 7 years of age.
Diphtheria, tetanus, whooping cough, polio, Haemophilus influenzae type b, `for children under 5 years of age
Tetanus, diphtheria, whooping cough, polio
Tetanus, diphtheria, whooping cough
Tetanus, diphtheria
Side Effects of the Tetanus Vaccine
The body system as a whole
The nervious system
Tetanus vaccine interactions
The tetanus vaccine is combined with other vaccines, so that a person can receive protection from several diseases with a single injection.
Tetanus-containing vaccines are provided free of charge as part of immunizations in most countries, it is easy to purchase.
There are several vaccine combinations that are recommended for children and adults at different ages.
Vaccines are made up of tetanus, diphtheria, and pertussis toxins that have been made non-toxic, but still have the ability to create an immune response. These vaccines do not contain live bacteria.
The cultivation of Clostridium tetani is carried out in a peptone-based medium and is detoxified with formaldehyde.
The detoxified material is then purified by serial ammonium sulfate fractionation, followed by sterile filtration.
The toxoid is then diluted with physiological saline (0.85%). Each dose contains the preservative thimerosal, a derivative of mercury, in an amount of 25 mg of mercury per dose.
This product does not contain an aluminum-containing adjuvant.
Immunization is active by the production of protective antibodies induced by toxoids against the exotoxin of Clostridium tetani.
These products transmit active immunity by stimulating the production of endogenously produced antibodies.
The onset of protection against the disease is relatively slow, but the duration is 10 years.
It is manufactured independently and as part of other combination vaccines.
It is presented in injections for intramuscular or subcutaneous use, it is a sterile solution of toxoid in isotonic sodium chloride solution.
Immunizations with tetanus vaccines, to obtain long-term protection, are accompanied by vaccines against diphtheria, tetanus and pertussis and with diphtheria and tetanus toxoids, the vaccination scheme implemented worldwide is as follows:
Three doses are applied and is usually given at 2, 4, and 6 months of age.
Four doses are applied and is usually given at 2, 4, 6, and 18 months of age.
It is given as a booster dose for children who received 3 doses of Diphtheria, Tetanus, Pertussis, Hepatitis B, Polio, Haemophilus influenzae type b.
This vaccine is given to infants as a booster dose at 18 months of age after completing a primary series of three doses of Diphtheria, Tetanus, Pertussis, Hepatitis B, Polio, Haemophilus influenzae type b.
This vaccine is given as one dose for children 4 to 6 years of age.
This is a booster dose for children who were immunized against diphtheria, tetanus, pertussis, and polio at an earlier age.
The booster dose strengthens or boosts the immune system to provide better protection against these diseases as children start school.
This vaccine is offered to all students in grade 9. This is a booster dose for children immunized against these diseases at an earlier age.
The vaccine can also be given to children 7 years of age and older who have not been fully immunized, and to adults or immigrants who have not been vaccinated or whose vaccination history is unknown.
People born in 1989 or later who missed their dose of Tetanus, Diphtheria, and Pertussis in Teens are eligible for one dose of this vaccine.
A booster dose of Tetanus, Diphtheria, Pertussis, Polio vaccine is recommended for adults who were vaccinated in childhood,
Increases immunity to previous doses of tetanus, diphtheria, and pertussis-containing vaccines.
Adults who were immunized against tetanus and diphtheria when they were younger should receive a booster dose of the Tetanus, Diphtheria vaccine every 10 years.
Adults who have not been vaccinated or do not have a prior immunization record should also receive the vaccine.
This vaccine can also be given to people with severe cuts or deep wounds if their last tetanus shot was more than 5 years ago.
It is important to know that, in general, the risk of problems from getting tetanus is much higher than from getting a tetanus shot.
You cannot get tetanus from the tetanus shot, however sometimes the tetanus shot can cause side effects. These may include:
Adverse reactions can be local and include:
Redness, warmth, edema, induration with or without sensitivity.
Hives and skin rash.
General malaise, headache, or body aches.
Transient fever.
Hypotension, nausea, and arthralgias.
Hypersensitivity reactions, characterized by severe local reactions (usually beginning 2 to 8 hours after an injection), can occur, particularly in people who have received multiple previous boosters.
The following neurological diseases have been reported to be temporarily associated with vaccines containing tetanus toxoid.
Neurologic complications include cochlear injury, brachial plexus neuropathies, radial nerve palsy, recurrent nerve palsy, lodging paresis, Guillain-Barré syndrome, and EEG disturbances with encephalopathy.
A severe allergic reaction (anaphylaxis) is very rare, but can occur within minutes of receiving the vaccine. Symptoms can include:
Redness, itching, or swelling of the skin.
Difficulty breathing or other respiratory symptoms.
Nausea, vomiting, diarrhea, or abdominal cramps.
Dizziness, low blood pressure, fast heartbeat.
It is contraindicated in people with hypersensitivity to thimerosal.
For passive immunization, use Tetanus Immune Globulin.
If you are hypersensitive to aluminum the alternative is the fluid toxoid for use.
Intramuscular injections should be administered with great care in patients suffering from thrombocytopenia or other bleeding disorders.
In the case of nursing mothers, it is unknown whether it is excreted in human milk.
In pregnancy it should be used with caution if the benefits outweigh the risks.
Its use is contraindicated if belimumab is being administered.
The vaccine should be administered subcutaneously in patients on anticoagulant therapy.
Immunosuppressive therapies can reduce the response to vaccines.


text:
DAY 5: A look back at our FA Cup fifth round derby win over Aston Villa
Matt Joyce
On Day 5 of our Christmas countdown, we look back at our win in Round Five against Aston Villa back in 1998...
In the 12 days leading up to Christmas we're giving Sky Blues supporters a '12 days of Christmas' feature, where every day in the build up to the big day we'll be reflecting on legends and big matches, as well as offering some fantastic competitions to celebrate the festive period. On Day Five of our 12 days, we look at one of our best ever wins in Round Five of the FA Cup, where the Sky Blues beat Aston Villa at Villa Park in 1998...
Coventry City progressed from Round Five of the FA Cup at the expense of local rivals Aston Villa in February 1998.
The only goal of the tight encounter came from Romanian Viorel Moldovan 18 minutes from time, to make sure City won the derby to progress into the FA Cup Quarter-Finals.
Moldovan's strike was only one of two goals he scored for the club as the Sky Blues ended Villa's ten-game unbeaten streak against them in derby matches.
Click on our gallery to see some of the best pictures from that magical day at Villa Park!

redpajama_set_name: RedPajamaCommonCrawl


text:
Davening: A Satanic, Perverted Practice at the Wailing Wall
July 6, 2018 by Yvonne Nachtigal
In the practice known as Davening, the Jews copulate with the feminine aspect of "god" while praying. Rabbi Schochet and HaRivash of San Diego Jewish World write that,
"Hassidic literature teaches that one of the reasons given for Hassidim swaying in prayer is based upon the analogy of the movement that occurs in the act of love making.
Prayer is like "making love to the Shekhinah."
The Baal Shem Tov is purported to have taught:
Prayer is zivug (coupling) with the Shechinah.'
Just as there is motion at the beginning of coupling, so, too, one must move (sway) at the beginning of prayer.
Thereafter one can stand still, without motion, attached to the Shechinah with great deveikut ("cleaving to God)
As a result of your swaying, you can attain great bestirment. For you think to yourself: "Why do I move myself? Presumably it is because the Shechinah surely stands before me." This will effect in you a state of great hitlahavut (enthusiasm; rapture). (Jacob I. Schochet, Tzavat HaRivash Brooklyn, NY: Kehot Publication, 1998, pp.54-55.) (http://www.sdjewishworld.com/…/davening-at-victorias-secret/)
"A favorite ploy of the talmudic jews is to have a religious leader or politician go to the Kotel (aka Western Wall or Wailing Wall) and pay homage to their man made rabbinical religion. It is an outward public profession of submission to the pharisaical faith for the whole world to see. Benedict XVI and the new saint John Paul II both went to the Wailing Wall to demonstrate their faith not in Catholicism but modern day Judaism…John Paul II set the precedent on 26 March 2000 by being the first to visit the Western Wall and place a prayer there. As Benedict XVI continued this sacrilegious and apostate practice, on 12 May 2009, nothing less is expected from Francis. There was much hemming and hawing by the Talmudists before John Paul II and Benedict XVI were allowed to go to the Wailing Wall and place their prayers in the magic stones." (http://callmejorgebergoglio.blogspot.com/…/francis-shekinah…)
So as you can see, its just not Jews who go to this wall and pray. It is presidents., heads of states and popes. And why would non Jews do this? Because they worship the same god…Lucifer. This part of the wall was never a part of the Temple. This was the wall for the Antonia Fortress that not only held the the judgement seat for Rome but also had a temple of both Jupiter and Venus on it (https://www.google.com/…/exploring-aelia-capitolina-ha…/amp/).
Rabbi Luria also allegedly talked to and had visions of Elijah. We know this wasn't actually Elijah, so what demonic spirit is manifesting to these Kabballists rabbis?
"Rabbi Isaac ben Solomon Luria Ashkenazi (aka Ha'ARI) was a 16th century Kabbalistic rabbi who claimed to have conversations with Elias (Elijah) from the Old Testament.
Many of his teachings went against and were contrary to earlier rabbinical teachings. We are digressing.
The reason Jews pray at the Western Wall is because Rabbi Luria told his followers that this site, which Christians were using at the time as a dump, was where the Temple had been located.
The reasoning Rabbi Luria gave behind this, is the Christians are the enemies of the Jews so they are defiling a Jewish holy place.
He further told them the Shekinah emanates from the wall. For those who don't know about Judaism, the Shekinah is the female aspect of God.
It suffices to say when God was in his original form he was a hermaphrodite and it is the Jews responsibility to reunite the Shekinah with the masculine Godhead the details of this are laid out in the Zohar a kabbalistic book.
When at the wall the Talmudists daven.
Davening is a ritualistic form of chasidic jewish prayer which involves using the whole body. If you have seen a Jew rocking back and forth you dear reader have seen one davening.
Rabbi Luria and later Hasidic Kabbalists taught in proper davening one is copulating with the Shekinah." (http://callmejorgebergoglio.blogspot.com/…/francis-shekinah…)
What kind of prayers do these people say while copulating with this feminine presence? Scriptures from the Bible? No, they come from the Talmud.
"Jewish prayer (Hebrew: תְּפִלָּה, tefillah [tefiˈla]; plural Hebrew: תְּפִלּוֹת, tefillot [tefiˈlot]; Yiddish תּפֿלה tfile [ˈtfɪlə], plural תּפֿלות tfilles [ˈtfɪləs]; Yinglish: davening /ˈdɑːvənɪŋ/ from Yiddish דאַוונען daven 'to pray') are the prayer recitations and Jewish meditation traditions that form part of the observance of Rabbinic Judaism.
These prayers, often with instructions and commentary, are found in the siddur, the traditional Jewish prayer book. However, if the Talmud mentions tefillah, it refers to the Shemoneh Esreh only." (https://en.m.wikipedia.org/wiki/Jewish_prayer)
The Shemonah Esreh:
"The Amidah (Hebrew: תפילת העמידה, Tefilat HaAmidah, "The Standing Prayer"), also called the Shmoneh Esreh (שמנה עשרה, "The Eighteen", in reference to the original number of constituent blessings: there are now nineteen), is the central prayer of the Jewish liturgy.
This prayer, among others, is found in the siddur, the traditional Jewish prayer book…
Observant Jews recite the Amidah at each of three prayer services in a typical weekday: morning, afternoon, and evening…
The language of the Amidah most likely dates from the mishnaic period, both before and after the destruction of the Temple (70 CE) at which time it was considered unnecessary to prescribe its text and content." (https://en.m.wikipedia.org/wiki/Amidah)
This ritual comes the Babylonian Talmud Era and are not holy prayers by any means.
And! In the true spirit of Roman Catholic "Indulgences" and bringing to mind Jesus overturning the temples in the Temple, if you can't make it to the wall, you can pay a "righteous" person to pray for you for between $2 to $18 a day. Or you can pay $3,600 for the "Choice Prayers" package~! If you think I'm making this up you can see for yourself what they offer at the Kotel: (https://westernwallprayers.org/aboutwwp/whatwedo.html).
The wailing wall is a demonic place where Jews and non-Jews copulate spiritually with a feminine presence and some even make a profit over it. Much like a divine prostitute, the presence encountered in this act is in fact Sophia, the feminine aspect of Lucifer.
Categories awareness, israel, kabbalah, zionism
The Wailing Wall & Evidence for the Real Site of the Temple in Jerusalem
The Third Temple and Plans for "Greater Israel"


text:
Welcome to Feenom
Feenom
fEEL good rIDE good
This area is used to describe your product's details. Tell customers about the look, feel, and style of your product. Add details on color, materials used, sizing, and where it was made.
FEENOM 2019 Sled EDIT
FEENOM Stainless chain necklace
Rock the Feenom chain necklace.
FEENOM RIDER - CLASSIC TEE
The FEENOM Rider Classic Tee
Size SM M L XL - Sold Out XXL
SM M L XL - Sold Out XXL
Andy Messner
"A slow release of sustained energy that keeps you going for the whole day, not just for a short time. "
KYLE NICOLL
"I use Feenom Preride not only for the energy and focus throughout my entire ride but for the recovery! " @akfullthrottle
Designed for Rider Performance
Black Pepper Extract:
Black pepper extract has a positive effect on absorption of nutrients from the intestine. This effect is known as "bioenhancement.". Piperine may be useful for people who suffer from conditions that cause malabsorption of nutrients and people suffering from malnutrition. Black pepper has been used for centuries to treat gastrointestinal distress, inflammation, pain and other disorders.17
Vitamin D3:
Many people don't get enough of this nutrient. While the body uses sunlight to make vitamin D, it cannot make enough if you live in northern climates or don't spend much time in the sun. This vitamin supports healthy cardiovascular function and inflammatory response. It helps maintain normal blood levels of calcium and phosphorus, which strengthen bones. It helps form bones and teeth. Supplementing with this vitamin can reduce the number of non-spinal fractures.
DMAE Bitartrate:
DMAE Bitartrate is also known as Deanol. Deanol is a precursor to the neurotransmitter choline. This is a naturally occurring compound in the brain. The various neurotransmitters play an important role in brain function and cognitive acuity and affect everything from how happy you feel to how much mental energy you have. In addition, DMAE has even been found to possibly have antiaging effects, especially on the skin, when used as a topical gel.13 DMAE can be a beneficial supplement for a greater overall sense of well-being.
L-Arginine:
Through a process involving an enzyme called nitric oxide synthase, L-arginine is converted to nitric oxide in the innermost lining of the arteries known as the endothelium. L-Arginine is well known to promote vasodilation during exercise or hypercholesterolemia (Definition: condition of very high levels of cholesterol in the blood).18 Vasodilation is hindered by this condition and L-arginine has been found to promote smooth muscle relaxation through nitric oxide production.4
L-Tyrosine:
L-Tyrosine: Tyrosine can be found in nuts, eggs, dairy products, meats, fish, beans, oats and wheat. Tyrosine is an amino acid and is commonly used for depression, sleep deprivation, chronic fatigue syndrome and as an appetite suppressant. Tyrosine is used to improve mental alertness. What has been found in research studies is that one of the main effects of L-tyrosine that have been reported are acute effects in preventing a decline in cognitive function in response to physical stress.22
Rhodiola Rosea Herb
Rhodiola rosea herb grows in the Arctic regions of eastern Siberia. Russians have been drinking rhodiola tea for centuries as an energy booster and Russian and Chinese scientists have researched the benefits of Rhodiola root for several decades. The root has a reputation for stimulating the nervous system, enhancing work performance, decreasing fatigue, and reducing high altitude sickness. This herb has been categorized as an adaptogen by Russian researchers due to its observed ability to increase resistance to a variety of chemical, biological, and physical stressors. The adaptogenic, cardiopulmonary protective, and central nervous system activities of rhodiola rosea root have been attributed primarily to its ability to influence levels and activity of monoamines and opioid peptides such as beta-endorphins. Interestingly, in smaller doses the herb is believed to be more stimulating than in larger doses.†
FEENOM LABS
It is our mission is to inspire peak rider performance through a combination of specific products and gear. We are dedicated to implementing cutting-edge science, pure nutrients, and industry professionals, to help riders improve their experiences and achieve their goals.
Subscribe to get special offers, giveaways, and the latest news!
© Feenom 2023
Feenom Lab


text:
Q: IEVRPresenterRegisterCallback in MVVM gives D3DERR_DRIVERINVALIDCALL I'm working with the enhanced video renderer in WPF and when creating an instance of IEVRPresenterRegisterCallback I sometimes get an annoying error of D3DERR_DRIVERINVALIDCALL.
Using the MVVM design, when I switch views... one view specifically has this presenter inside of it... and runs about 80% of the time when switching between views. When a view is closed, everything is disposed... so going back to the same view will recreate the objects.
The problem is sometimes it does work... and I've nailed down the cause, but can't figure out a solution.
        int hr;
        object comObject;
        Exception exception = null;

        // A COM object we query form our native library.
        IClassFactory factory = null;

        // Create our 'helper' class.
        var evrPresenter = new EVRPresenter();

        // Call the DLL export to create the class factory.
        if (ProcessBits == 64)
        {
            hr = DllGetClassObject64(EVR_PRESENTER_CLSID, IUNKNOWN_GUID, out comObject);
        }
        else
        {
            exception = new Exception(string.Format("{0} bit processes are unsupported", ProcessBits));
            goto bottom;
        }

        // Check if our call to our DLL failed.
        if (hr != 0 || comObject == null)
        {
            exception = new COMException("Could not create a new class factory.", hr);
            goto bottom;
        }

        // Cast the COM object that was returned to a COM interface type.
        factory = comObject as IClassFactory;

        if (factory == null)
        {
            exception = new Exception("Could not QueryInterface for the IClassFactory interface.");
            goto bottom;
        }

        // Get the GUID of the IMFVideoPresenter.
        Guid guidVideoPresenter = typeof(IMFVideoPresenter).GUID;

        // Creates a new instance of the IMFVideoPresenter.
        hr = factory.CreateInstance(null, ref guidVideoPresenter, out comObject);

        // QueryInterface for the IMFVideoPresenter.
        var presenter = comObject as IMFVideoPresenter;

        // QueryInterface for our callback registration interface.
        var registerCb = comObject as IEVRPresenterRegisterCallback;

        if (registerCb == null)
        {
            exception = new Exception("Could not QueryInterface for IEVRPresenterRegisterCallback.");
            goto bottom;
        }

        // Register the callback to the 'helper' class.
        registerCb.RegisterCallback(evrPresenter);

        // Populate the IMFVideoPresenter.
        evrPresenter.VideoPresenter = presenter;

    bottom:
        if (factory != null)
        {
            Marshal.FinalReleaseComObject(factory);
        }

        if (exception != null)
        {
            throw exception;
        }

        return evrPresenter;

When facotry.CreateInstance(null, ref guidVideoPresenter, out comObject) runs... the comObject returns IEVRPresenterRegisterCallback most of the time, however other times, it spits out null and the HRESULT is D3DERR_DRIVERINVALIDCALL which so happens to be a very vague error code.
When this happens my application eventually catches the exception and continues without showing any video.
Has anybody seen something like this before in this type of design?
Cheers.

redpajama_set_name: RedPajamaStackExchange


Thank you for your interest in having a unit custom made by yours truly.
Here you will find references on how to measure your head so that it may be a secure fit.
The size of the custom units made here range from 20.5" to 23.5" in diameter.


text:
Topic Area: Executive Director
Mars Society Appoints New Full-Time Executive Director
The Mars Society is very pleased to announce that James L. Burk has been appointed as the organization's new full-time Executive Director, supervising the group's world-wide efforts to promote the human exploration and settlement of the planet Mars. In this role, James will oversee the organization's fundraising efforts and high-level networking, lead and coordinate volunteers and chapters, both in the U.S. and around the world, and coordinate any organizational involvement in informing government representatives about humans-to-Mars. Commenting on his new position, James… READ MORE >
Mars Society to Hire Full-Time Executive Director
The Mars Society announced today that it is looking to hire a full-time Executive Director for the organization. The Mars Society is the world's largest and most influential space advocacy non-profit organization dedicated to the exploration and human settlement of the planet Mars. With thousands of members and many chapters around the world, the Mars Society operates two Mars analog stations where crews carry out research and test methods of Mars field exploration on Earth. The organization also convenes annual… READ MORE >
Get the latest news about Mars and our organization delivered right to your inbox.
Recent News & Announcements
'Coming Soon' Trailer from MarsVR
Red Planet Live Podcast to Welcome Astrobiologist Graham Lau on Jan. 18th
Mars Society Announces Telerobotic Mars Expedition Design Competition
NASA's Carol Stoker to Discuss Search for Life on Mars – Virtual Talk (MSC)
NASA at Its Best [Zubrin Op-Ed]


A completed rebuild from our facility ready to ship to the customer.
Machine Tool Rebuilders, Inc. works at providing quality work to all of its customers. Customer Satisfaction is valued by the MTR Staff and each job is given special and proper attention. The staff at MTR has a combined 50 years of scraping and aligning, letting the work speak for itself.
MTR has a full machine shop that includes an 14x60 Surface Grinder and 14ft Planer that allows the staff to make personalized parts that are no longer avaliable for purchase. This allows them to fully meet the challenges of each machine repair. This equals a faster turn-around time on repairs putting you back to work with your machine as soon as possible.
All quotes good for one year after issued date.
As the saying goes: "if we can't fix it, it ain't broke!"


text:
Reverse Pharmacology (RP) is a science of integrating documented experiential hits, into leads by transdisciplinary exploratory studies and further developing into drug candidates by experimental research.
In this approach, the candidate travels a reverse path from 'clinics to laboratory' rather than classical 'laboratory to clinics'.
RP enhances the connection, communication and collaboration between modern sciences and technology with traditional medicine and modern biomedicine.
It offers a major paradigm shift in drug discovery. Instead of serendipitous findings pursued randomly an organized path from clinical observations and success is established.
Recently, India has amended the Drug Act to include a category of phytopharmaceuticals to be developed from medicinal plants by Reverse Pharmacology, with evidence of quality, safety and efficacy. These drugs will be distinct from traditional medicines like Ayurvedic, Unani or Siddha.
History of Reverse Pharmacology in India
Sir Ram Nath Chopra was a pioneer in the field of experimental pharmacology of indigenous drugs of India. Along with Gananath Sen he laid the foundation of RP of medicinal plants by pursuing clinically documented effects of Ayurvedic drugs.
Sen and Kartik Bose in 1931 demonstrated the antihypertensive and tranquilizing effect of Rawolfia serpentina.
Scope of Reverse Pharmacology
to understand the mechanisms of action at multiple levels of biology and to optimize safety, efficacy and acceptability of the leads in natural products based on relevant science.
Scientifically validated and technologically standardized botanical products may be explored on a fast track using innovative approaches like reverse pharmacology and systems biology, which are based on traditional medicine knowledge.
Salient features of reverse pharmacology:
Classical drug discovery process is an expensive and time-consuming process. It involves 10 – 15 years of investigation period and investments of the order of US $ 1 to 1.5 billion. This extremely complex, technology bases and capital-intensive process has resulted in 'target rich lead poor' performance. Whereas Reverse Pharmacology is an economical, time sparring and has least bottlenecks. It effectively reduces the duration of drug development to 4 – 5 years.
It also allows understanding the mechanisms of drug action at multiple levels and helps in optimizing the safety, efficacy and acceptability of the leads from the natural products.
RP utilizes traditional knowledge of medicines to discover drugs and is also called as a path of pharmacology from the bedside to bench experiments.
In this process 'safety' remains the most important starting point and the efficacy becomes a matter of validation.
The path of classical and reverse pharmacology approach:
Research and development path for natural products:
The different paths of development of botanical medications are:
The ethno medicine path – Based on observing field use of plants and then standardizing for the activity e.g. tubocurarine isolated from Curare, commonly known as South American arrow poison.
Through screening of extracts in selected models, isolation of the active principles and then definition of a single molecule, for preclinical and clinical evaluation such as reserpine from Rauwolfia serpentina.
The herbal product path of screening of extracts in models and then testing for efficacy and safety in a clinical set up such as Ganoderma lucidum and Hypericum perforatum.
The holistic path of using the formulation mentioned in classical texts of Ayurveda and then evaluating efficacy of popular medicines in use such as chavanprash.
The drawbacks of these botanical medications are:
Although botanical medications continued to be produced in every country, their clinical efficacy was usually not evaluated and the composition of these complex mixtures was only crudely analysed. Investments in these methodologies remained scarce.
Failure to distinguish folklore from traditionally established systems like Ayurveda and TCM (Traditional Chinese Medicine).
Lack of proper identity and implementation of Good Laboratory Practices, improper experiential documentation.
Absence of Phase II, dose optimizing studies.
Cultural prejudice for modern medical sciences.
Lack of political and financial support. Plants are compositional complex mixtures of chemicals and studying them is a challenge.
Reverse pharmacology provides an open – ended approach, to guide us from the traditional wisdom of Ayurveda to the current state-of-art developments in biology. It offers a major paradigm shift in drug discovery. Instead of serendipitous findings pursued randomly, an organized path from clinical observations and successes is established.
R & D path for natural products:
Reverse Pharmacology and Ayurveda:
Ayurvedic knowledge and experiential database can provide new functional leads to reduce time, money and toxicity – the three main hurdles in the drug development.
Basic principle of Ayurveda is based on personalized approach can be used for creating personalized, customized or designer medicines. Therefore, science of Ayurveda has the potential to revolutionize modern medicine and drug discovery processes.
A golden triangle consisting of Ayurveda, modern medicine and science will converge to form a real discovery engine that can result in newer, safer, cheaper and effective therapies.
The salient features of drug discovery by reverse pharmacology through Ayurveda are:
The search is based on Ayurvedic medicine research, clinical experiences, observations or available data on actual use in patients as a starting point.
Use of principles of systems biology where holistic yet rational analysis is done to address multiple therapeutic requirements.
Since safety of the materials is already established from traditional use track record, we undertake pharmaceutical development, safety validation and pharmacodynamic studies in parallel to controlled clinical studies.
The approach has attracted considerable attention, nationally and internationally: Central Scientific Instrumental Research (CSIR) and Indian Council of Medical Research (ICMR) have done clinical trials with natural products. Moreover, Central Council for Research in Ayurveda and Siddha (CCRAS) has recently adopted the golden triangle approach for some new indications of old drugs, as well as for Ayurveda.
A New Millennium for Technological Leadership Initiative (NMITLI) has resulted in hits, leads and effective formulations for diabetes, arthritis and hepatitis with novel mechanism of action and intellectual property as shown in the following table.
Phases of reverse pharmacology:
RP can be perceived to comprise of three phases or domains.
Experiential phase that includes robust documentation of clinical observations of the biodynamic effects of standardized Ayurvedic drugs by meticulous record keeping.
Exploratory studies for tolerability, drug-interactions, dose-range finding in ambulant patients of defined subsets of the disease and para- clinical studies in relevant in vitro and in vivo models to evaluate the target-activity.
Experimentalstudies, basic and clinical, at several levels of biological organization, to identify and validate the reverse pharmacological correlates of Ayurvedic drug safety and efficacy.
The progress of RP in India has led to the following leads from Ayurvedic medicinal plants:
Disease Plants Ayurvedic forms Phytoactives
Diabetes mellitus P. emblica E. littorale Fruits-Chyavanprash Entire plant ghana Gallic acid Swertiamarin
Arthritis T. cordifolia S. anacardum Amrita bhallatak Avaleha Polysaccharide Bhilawanol
hepatitis Multi-ingredients Phalaghrita Multiple
Psoriasis A. mexicana Latex ghana Berberine
NASH P. karroa Powder Picroside 2
Malaria N. arbor-tristis Leaves-paste unknown
Pre-cancer Lesions C. longa Powder Curcumin
Thus, the Reverse pharmacology as an organized trans-discipline would fill up the gaps between the serendipity and research creativity.


New Delhi: India's limited overs captain Mahendra Singh Dhoni feels his heir apparent Virat Kohli will make a good captain in all three formats.
Dhoni, showering praise on India's Test captain, said Kohli is always pushing the envelope and that is what makes him special.
"Virat has been fantastic over the years; if you see what really counts is how you can improve your game. Right from the very first game that he played for India, he is somebody who always wanted to improve and he always wanted to contribute in the team's win and by contribution it was not a small, he always wanted to be the Man of the Match in those terms," Dhoni was quoted as saying by Tamil Nadu T20 Premier League's official website.
"So I feel that he was always pushing himself when it comes to fitness, reading of the game, execution of his plans I feel that's what makes him very special," he said.
"After that, it's how you lead your team and since he has the experience of leading RCB (Royal Challengers Bangalore) and also now that he is the Test captain for the more than a year, I feel in a way he has groomed himself looking at all the challenges that he had to face.
"I feel that he has done an exceptional job and that he has a very bright future ahead of him when it comes to being the captain of the teams," added the wicket-keeper batsman.
Dhoni returns to action with a couple of T20 Internationals against the West Indies to be held in USA on August 27 and 28. He is looking forward to the short-series and also working with new coach Anil Kumble.
"Well Anil Bhai, I have played with him, I have played under him and he's a very special man. He's one of the few players, irrespective of the conditions whether it's (assisting) spin bowling or not, whether we're playing in abroad or not he was somebody who was very aggressive when it comes to his bowling. He was somebody who put in a lot of hard-work who would prepare very well over a period and you know he's just fantastic," said Dhoni.
"The integrity part, the honesty part, the hard-work, the affection and yes the big change has been the sense of humour.
Dhoni has more free time after retiring from Tests and he utilises that by working on his fitness.
"In my case, my motto was to lose a bit of weight; technically in the terms of the fat percentage and what you have to be careful about is when you try to lose fat you don't want to end up losing muscle also. I have managed to lose two kilos," he added.


Find everything about Pendant Track Light on our site. You may also be interested in information about Switchable Track Lights, How To Install Track Lighting, Led Track Lighting. We will be happy if this web site can help you.


text:
Q: How to catch a FacesFileNotFoundException? How can I catch a

com.sun.faces.context.FacesFileNotFoundException

in a Java EE web application?
I tried it with adding the following lines in my web.xml file but I was not successful:
  ...
  <error-page>
    <error-code>404</error-code>
    <location>/404.jsf</location>
  </error-page>
  <error-page>
    <error-code>500</error-code>
    <location>/404.jsf</location>
  </error-page>
  <error-page>
    <exception-type>FacesFileNotFoundException</exception-type>
    <location>/404.jsf</location>
  </error-page>
  <error-page>
    <exception-type>FileNotFoundException</exception-type>
    <location>/404.jsf</location>
  </error-page>
  <error-page>
    <exception-type>FailingHttpStatusCodeException</exception-type>
    <location>/404.jsf</location>
  </error-page>
</web-app>

A: You need to specify the FQN (Full Qualified Name), not just the N as exception type.
<exception-type>com.sun.faces.context.FacesFileNotFoundException</exception-type>

Alternatively, if you already happen to use OmniFaces, register its FacesExceptionFilter and then the FacesFileNotFoundException will be handled as 404.


Doubts regarding request and response objects.
Why both GenericServlet and HttpServlet implements Serializable interface ?
When is J2EE6 JSP/Servlet Developer Certified Professional Exam going to be available?


text:
PO Funding Guaranteed Until End Of Parliament
Defra has pledged to maintain current levels of funding for recognised producer organisations (POs) until the end of the current parliament following Brexit.
The announcement means that the government will take over the £35 million of funding, which is currently provided via the EU Fresh Fruit and Veg Scheme until 2022. The funding will continue to be matched by growers in the 33 UK POs.
NFU Horticulture and Potatoes Board chair Ali Capper said that she was delighted by the news, adding it would provide "much needed clarity and certainty for the grower-members of producer organisations which sell 50 per cent of all British fruit and veg."
Photo Caption: There are 33 producer organisations in the UK.
Photo Credit: pxhere


text:
'use strict';

// Regression test for https://github.com/nodejs/node/issues/13262

const common = require('../common');
const assert = require('assert');
const async_hooks = require('async_hooks');

if (!common.isMainThread)
  common.skip('Worker bootstrapping works differently -> different async IDs');

let seenId, seenResource;

async_hooks.createHook({
  init: common.mustCall((id, provider, triggerAsyncId, resource) => {
    seenId = id;
    seenResource = resource;
    assert.strictEqual(provider, 'Immediate');
    assert.strictEqual(triggerAsyncId, 1);
  }),
  before: common.mustNotCall(),
  after: common.mustNotCall(),
  destroy: common.mustCall((id) => {
    assert.strictEqual(seenId, id);
  })
}).enable();

const immediate = setImmediate(common.mustNotCall());
assert.strictEqual(immediate, seenResource);
clearImmediate(immediate);

redpajama_set_name: RedPajamaGithub


text:
すべてを表示
Complex systems
Medicine, Dentistry, and Pharmacy
Graduate School of Engineering (18)
Graduate School of Medicine (17)
Graduate School of Science (15)
Graduate School of Bioagricultural Sciences (8)
Institute of Transformative Bio-Molecules (7)
Graduate School of Environmental Studies (6)
Institute for Space-Earth Environmental Research (6)
Institute for Advanced Research (5)
ITbM (5)
Arabidopsis (4)
Graduate School of Informatics (4)
Hisashi Kajimura (3)
Institute of Materials and Systems for Sustainability (3)
Interaction between living organisms (3)
Kenichiro Itami (3)
Magnetic field (3)
Nagoya University Foundation
TOP > Researchers' VOICE > Michiko Niimi
Researchers'
VOICE No. 31
Michiko Niimi
Nagoya University Museum / Graduate School of Informatics
My favorite saying: Listen to what the remains tell you
Q: Why did you choose this saying?
It's something my mentor told me when I was a student. We archaeologists are always thinking about how we can get as much information as possible from the remains we unearth. Just blankly gazing at remains will tell us nothing. But if we observe remains with the experience of extensive observation training, they will tell us many things. So, this saying tells us that we must always be ready to listen to what the remains tell us. I've spent many years studying archaeology, but even now — especially now — I strongly feel that this is completely true. It's something I always try to remember.
Q: What kind of research are you doing?
When we excavate archaeological sites, we unearth all sorts of things. Some of the things we discover are bones, including shells and fish bones that were thrown away after people ate them and human bones buried in graves. My research involves using these bones and shells as materials to help us reconstruct the lives and cultures of ancient peoples.
Field work at Onnetou Shell Mound in Nemuro City, Hokkaido
Q: How did you get into this research?
At university, I majored in archaeology for no particular reason. For my first dig, I went to Hokkaido to excavate the remains of a home thought to have been built around the 12th century. As we removed each layer of soil, the shape of the dwelling gradually appeared, and I realized how interesting excavation was. In the home, there was a cooking stove with ashes left in it. We sifted the ashes and found a lot of burned fish vertebrae. They were from a type of codfish called saffron cod. From the size of the bones, we learned that it was a full-grown fish, probably caught when it came to the shallows to lay eggs in the dead of winter. I was amazed that with nothing but some small bones, we were able to learn the season the fish was caught. That was what inspired me.
Q: What sorts of things make you think that research is interesting or rewarding?
I guess when I discover something that may overturn conventional theories or lead to completely new prospects. I really enjoy making observations and taking measurements, collecting and aggregating data, and carving a path to the final conclusion. Although I admit, I too often find something that makes me think, "Wow, this is a big deal!" only to later realize it's not that significant.
Excavation at Hinode Shell Mound in Hamatonbetsu, Hokkaido
Q: Your study "There Were Many Pigs in Okinawa 7,200 Years Ago" is really impressive. Could you tell me your most memorable experience from your field work in Okinawa (the southernmost islands of Japan)?
It was once thought that people in Japan began raising pigs as livestock during the Yayoi Period (about 3,000 years ago), but this study shows that many pigs had already been introduced to Okinawa from China 7,200 years ago. Even now, people in Okinawa eat much more pork than on the main island of Japan. Okinawa is known for its unique food culture; they eat not only pig meat but also its skin and blood. In fact, large amounts of bones from pigs eaten by people have been unearthed at remains from a few hundred years back in the middle and early modern ages. To be honest, even I first thought that the bones unearthed at remains over 7,000 years old had to be from wild boars that they hunted. I couldn't believe that people were raising pigs so long ago, even in Okinawa.
So we went to Okinawa to see materials said to be boar bones that were unearthed from the 7,200-year-old Noguni Shell Mound. When we studied the materials, we saw that the lower jawbones were all shaped like those of pigs (photo below). Pigs are farm animals that evolved from wild boars that were domesticated over the course of thousands of years. It is well known that when animals are domesticated, the shapes of bones in various parts of their bodies change. For example, pigs have developed an indentation in the lower jawbone (indicated by arrows in the photo) that boar lower jawbones lack. I found that every single jawbone unearthed from the Noguni Shell Mound had this kind of indentation. It was so shocking to me that I couldn't help but cry out, "What? Are they all pigs?!"
Unearthed lower jawbones of pigs
Q: Do you ever feel discouraged? What do you do to recharge?
From spring to autumn, I go to many places to excavate and investigate materials. I have a lot of wonderful memories of beautiful scenes from these survey sites — Lake Kutcharo after a rainfall, Hakata Bay sparkling in the setting sun — and when I remember these scenes, I can usually overcome any difficulties I'm facing.
A day off from excavation
Q: Please tell us a story that you can talk about now.
I'm not good at speaking in front of people, so when I became a lecturer, I was worried if I'd be able to give a lecture in front of so many students in class.
Q: What are your goals and ambitions for the future?
I have many research topics I want to address in future, so I want to see and examine a variety of different materials for that. Due to the COVID-19 pandemic, it's been a while since I've gone abroad to see materials, so I want to resume overseas field work as soon as possible.
Name: Michiko Niimi
Affiliation: Nagoya University Museum / Graduate School of Informatics
Title: Associate Professor
Dr. Niimi earned her PhD after completing the doctoral program in Archaeology at the Graduate School of Humanities at the University of Tokyo. Before taking her current position, she worked as an assistant professor at the University of Tokyo's Faculty of Letters and at Nagoya University's Graduate School of Human Informatics.
Her hobbies include nature walks and fishing. These excursions often double as opportunities to collect modern skeletal specimens to use in her research, such as bodies of birds and mammals on the ground or fresh fish.
No. 33 December 7, 2022
Professor Kengo Sudo
No. 32 September 26, 2022
Associate Professor Katsuhiro Shiratake
No. 31 July 5, 2022
Associate Professor Michiko Niimi
No. 30 February 1, 2022
Associate Professor Tadaaki Furuhashi
No. 29 February 19, 2021
Associate Professor Jun Ueyama
Institutes of Innovation for Future Society
Institute of Transformative Bio-Molecules
Office for GaN Research Strategy
Kobayashi-Maskawa Institute for the Origin of Particles and the Universe
Center for Low-temperature Plasma Sciences
Academics-Industrial Cooperation
Collaborative Research / Academics-Industrial Cooperation


text:
Too Much Talk about Space | Ayelet Lerman, 2012
Artists: Ayelet Lerman in collaboration with Zemer Sat, Guy Yitzhaki and Neta Cohen
Curators: Sala-macna | Mamuta at Daniela Passal House, Ein Karem
The project Too Much Talk aboutSpace, concluding 18 months of Ayelet Lerman's stay at Mamuta's Studios is an invitation to a wonder visit which embodies a fascinating encounter between sound and visual art in four performances that were turned into unique musical instruments: a metal chimney attached on the mechanism of an old carousel is transformed into a rotating instrument on which she plays, attached to it by her artificial hair. The viewers watch as they spin on another carousel or swing on a seesaw. Another work incorporates Ayelet and Zemer Sat into Sala-manca's installation Church of Criticism, turning the (wooden) church into a resonance box with taut strings along its length, as the church itself becomes the instrument of the uncompromising luthiers. Another collaboration, with Guy Yizhaki, is a dream in the sounds of spring nights, taking place in the building's backyard.Lerman's sound and playing activate Yizhaki's video work, forming a dialogue that illustrates the wondrous reality of the site, located in a complex historical and political space. The last work is 5 Minutes of Silence, collaboration between Lermanand Neta Cohen, in which the environmental noises were composed and emphasized to illustrate the silence, in a dialogue with John Cage's famous work, 4:33.
Ayelet Lerman is a sound, performance and installation artist, creating at the Daniela Passal Art and Media Center as an artist in residence. She graduated the School of Visual Theater, and received the 2010 Jerusalem Mayor award for her graduation work. She studied viola at the Music Academy in Jerusalem, Tel Aviv and Bologna (Italy). She collaborated with various artists and displayed her works in festivals, culture events and exhibitions. This is her first solo exhibition.
The exhibition is a joint production of Mamuta at the Daniela Passal Art and Media Center and Hazira


After you click the "Available Now" button, the way the titles are sorted changes from "Added to Site" to "Relevancy." For best results, consider re-sorting the collection by "Most Popular" (this is a great way to find yesterday's best sellers you might have missed!) or "Added to Site" to catch the newest titles that just became available.
Now you see a collection of popular, available titles to check out!


Mario Williams came to the Dolphins a year after his time in Buffalo ended in failure and drama.
The failure happened because Williams didn't seem to fit into Rex Ryan's defense and his statistics suffered -- either because he wasn't a fit or simply lost something. The drama came when Williams began discussing his situation and making no secret of the fact he was unhappy and wasn't. There was also some drama when teammates recognized Williams wasn't exactly trying very hard.
Well, Williams is with the Dolphins now and his experiencing failure again. But Wednesday it became clear we're not at the drama stage at all -- at least not publicly.
Williams, who has only one sack among his six solo tackles in six games, was benched last game. But he's not ripping anyone over the situation.
"By all means I've got to get better with all regardless, not even talking about whether I'm starting or not," Williams said Wednesday. "You've just got to better and I think each and every one of us have to do the same. Each and every one of us we still have a lot of work to do, still have a lot of rhythm to catch up with, with situations in the pass game, run game, whatnot. I think everybody would say the same thing."
It was something of a surprise when Williams didn't start last week but Williams wasn't shocked.
"No, because that had been … it's an open locker room for us," he said. "We've already talked about different ways to get guys spark or get guys going, try to manage snaps, things like that. The first five games it was pretty heavy on the defense as far as the amount of snaps and things like that … no, it wasn't a surprise."
So does Williams want to get back in the starting lineup? Sure. Does he expect to keep coming off the bench?
"I have no idea," he said. "It's just whatever the coaches say as far as schematically or the amount of plays or whatever. It's not my call."
Question after question on Wednesday gave Williams the forum and the opportunity to become an issue. Williams was even served up a chance to rip the Bills and he declined.
This is good. There is nothing worse than a player who is not performing also becoming a malcontent or locker room problem.
Williams isn't playing well. But the situation isn't full fledged Buffalo bad at this point because ... no drama.


In 2012 Nikolai Raisov, a Menshevik of uncertain age, died in Dublin.
He was found with notebooks of various quality containing writing of varying clarity on his person and in the two bags he carried.
and shake up everything important.
Thanks to Detective Sgt. Connor O'Connor for access to the records. This book is dedicated to him and to Nikolai Raisov.
It can safely be stated that there is no such thing as an individual human being.
I understand that this, as a first sentence, does not promise a riveting plot but bear with me.
Whether we look at the supposed individual from the physical or the mental perspective we quickly find, with only the least effort that the illusion of selfhood falls to pieces in our hands and turns to dust.
Physically we are not just a collection of limbs, of systems, of tissue, organs, cells and genes whose functions and interactions are impossibly fluid and multiple but we are also home to colonies of microorganisms. These organisms enjoy a particular kind of environment and they seek actively to create and reinforce it. They influence the choices we make in order to maintain the conditions they need to thrive within our bodies. Could we be simply vehicles for these tiny creatures?
Think of the nervous system; that wonderful electrical and chemical dance of the CNS. The volume of information that our Central Nervous Systems can process is vastly larger than the amount of information of which we can be consciously aware at any moment and so the CNS is making most of our decisions before we become aware of them. It promotes the feeling that our consciousness is being created "elsewhere"- perhaps in a shed in the garden next door or in your shoes.
Even that celebrity of modern times the brain turns out to be only A brain and to have competition from a similar collection of cells in the gut.
In traditional Chinese medicine the brain is referred to as "The Sea of Marrow" and appears to have little function. Most of what we think of as the work of the brain is carried out in this paradigm by the Liver and the Heart.
From the point of view of the consciousness the actions and functions that make us who we are happen too fast and in too complex a manner for us to understand.
We run along behind all this trying to piece together a story from the best available evidence like characters in a fairytale chasing crumbs and trying to create another, discrete individual from them- a golem of bread perhaps.
The imaginary individual we are dealing with here was called Connor O'Connor and he was as unaware of the factors that caused him to be Connor O'Connor and act in a Connor O'Connorish way as the rest of us are.
He woke without an alarm and from the same dream as always. He never remembered the dream, he never knew he even had the dream; all its effects were in his body.
If you had asked him he would have told you that he awoke with a Tom Waits song already playing in his head- the quality of Waits' voice and the concept of time mixing together to make him feel disoriented and somewhat sad.
As he sat up he stretched and clicked his jaw, removing the split he wore at night to stop him clenching his teeth. No wait, nothing stopped him clenching his teeth but the "fully adjusted hard occlusal splint" stopped the painful side effects in the teeth and gums, mostly. One good side effect was that he had very large Masseter muscles, which made him harder to knock out. Perhaps there was some rationalisation there.
He winced slightly as he put weight down on his left leg and felt a little bolt of electricity shoot up to his hip.
He straightened up and began the joint mobility exercises he did every morning if he could. Rolling all his joints in turn from this neck to his ankles gently feeling all the cracks and pops.
In the kitchen he made coffee that he put in a blender with butter and coconut oil. This was a variation on the traditional Tibetan Yak 's milk tea. The idea was that the fats in the oil and butter caused the elements of the coffee to be absorbed more slowly.
This was often the kind of thing he thought about and yet he also wondered if he should expend energy on thoughts like this.
At the time he had felt the poem was surprisingly glib for Cohen. However as he got older he began to feel more and more that it had something to say regarding the ego and the proper use of energy.
Life was full of these contradictions or paradoxes, one opening into the other like a labyrinth that stretched exactly as far as you wished it to go and opened back into the world with a shake of the head, mostly.
Then he mixed up some oak meal with peanut butter and cinnamon.
He put the coffee and the oatmeal on the table and drank about half a litre of water before he sat down to eat.
After breakfast (energy, inflammation and brain function dealt with orally to begin the day) he took the hottest shower he could take. He looked in the mirror. He could get away with not shaving for another day or two. It was winter and a cold one and he liked to grow as much of a winter beard as his job would allow.
He looked out a window at the street. Grey and dark and cold- even for October in Dublin. A good place to set some kind of detective book.
A deep breath and time to go to work.
Today, June the sixth, is the first birthday of this blog.
The whole novel will be published, from start to finish, all free. I will try to post a chapter every two weeks or so but I can't absolutely promise to keep exactly to that schedule. I'll do my best though.
When the whole work has been up on the blog I will publish the novel as an e-book for anyone who wants to buy a copy but there's nothing to stop you reading the whole thing for free here. Read it, enjoy it and tell your friends.
Best, Jamie and all at Hovel Press.
made only of impact and sound.


Piaggio, an Italian company, is known for its elegant scooters in the market. Now, the company is launching another hot looker this September, the Vespa Elegante. The Vespa Elegante is an India-specific scooter which is going to be an accessorized version of the Vespa VX.
The exclusive scooter will be come in Crete Senesi Brown color that is seen on the Vespa Primavera. The Elegante will also come with broader split seat which is finished in a light brown color. A foldable front-apron mounted carrier and Elegante badges are the other possible additions.
The Elegante's ex-showroom price could be Rs. 79,000. The Elegante will use a triangular front grille and the round headlamp will be retained. The seats of the Elegante will adopt a split design to give it a retro look.
The Vespa Elegante will be powered by the same 125cc engine that powers other scooters in the Vespa range. This engine produces 10 BHP of power and 10.6 Nm of torque. Piaggio offers a host of customization options for buyers of the Vespa scooter. Since the number of customers are less, buyers prefer to keep their scooters slightly exclusive by opting for these customisation options. Tubeless tyres and a disc brake for the front wheel and a drum brake will handle braking at the rear wheel.


Play IconMania: Movie & Icon Quiz for FREE now!
IconMania: Movie & Icon Quiz is a Pictionary game where you have to guess the pop icons. There will be logos and icons of movies, celebrities, brands, countries, cool people, and anything you can think of. You just have to guess the pic to solve then pop icon puzzle. Some of them are easy and some are quite challenging, but this is definitely a very cute game. This icon mania is truly the best casual game and the most iconic quiz you can find!
If you love pictionary and guess the pic games, you will love our icomania game! Now you can play guess the icon from your Android device. We handcrafted some of the most awesome logos and icons that you have to guess. We have created over 1000 logos and icons so you will have a lot of excitement and fun playing this logo quiz cute game. The pictures will vary. Sometimes you will find logo & movie icons. Sometimes they're logos of cool people or brands. These people can be movie stars, celebrities, famous actors, or famous artists. We created this mix between icomania & movie game just for an icon mania like you. We challenge you to download our game and test your knowledge in this awesome iconic quiz!


Kari attended the Society of Women Engineers Meet and Mingle event at Hedonist Artisan Chocolates.
As a graduate coordinator in optics, Kari went above and beyond the call of duty. She went to this event to assess the value for her students and to network with other women engineers in the area. She left the event with the following words: "From what I could discern, most of the individuals who were in attendance were women working in industry (and a female faculty member from RIT). I think it'd be a great organization to tell our graduate Hajim women about and encourage them to participate in their events. Additionally, if it is in GSO's/Hajim's budget to sponsor women who would like to attend these events, I think that would be wonderful. I think it would show our ladies that the University is making an honest attempt to support them through their graduate degree, help them engage with the local community, and offer different types of professional development." Kari is actively engaged with the engineering community both on and off-campus and is willing to explore opportunities to support her students.


text:
Robert Pattinson on Zoe Gravitz in Lux in 'Batman' Trailer
Posted By: Lois Yates
Batman has played Hollywood heroes including Christian Bale, Ben Affleck and George Clooney, but Robert Pattinson is probably still the best Bruce Wayne.
British Hunk, 35, is playing a cartoon character for the first time "mixture" And it sends fans frenzy after takeoff In the new trailer for the upcoming live-action movie.
During Sneak Peek, which came out on Monday, the star shows off her ripped suit to reveal her ripped body.
It also appears that Pattinson gets along with Zoe Kravitz, who will play Batman and Catwoman.
In the trailer, a crime-fighting couple fall in love while pursuing a Gotham City serial killer nicknamed "The Riddler".
"If we don't get up, no one will," Gravitz tells Batman, who looks him gently in the eyes.
Ready to tear! After delays related to the pandemic, the film will finally hit theaters in early March.
The actors have strong screen chemistry in the trailer and their characters can then flirt with each other.
"You have a lot of cats," Batman says as he enters Catwoman's apartment, which is full of cats.
"I have something to stay away from," Gravitz's character says, referring to Batman being an orphan, an eloquent response.
The film is the first film to portray the famous cartoon character Pattinson.
Fans flock to YouTube To capture Kochian's comments on Pattinson's portrayal at the bottom of the trailer.
"I am so excited to see Robert return to mainstream cinema. One fan exclaimed: This movie is going to be great.
"It will be one of the best Batman movies ever. And Robert Pattinson will surprise everyone. The cinematography looks amazing," said another, referring to the film directed by Matt Reeves.
YouTube fans flocked to comment on Pattinson's portrayal.
Meanwhile, Reeves It was announced last week that late musician Kurt Cobain was inspired by her while writing the film.
"When I write, I listen to music, and when I write my first show, I wear Nirvana's Something in the Way," Reeves, 55, told Empire. "Then, instead of turning Bruce Wayne into the Playboy version we've seen before, there's another version that went through a lot of tragedies and became a single."
It's been more than two years since the selection of Batman Pattinson was announced, and the product will be on hand starting March 2020 as a health restraint for Hollywood's epidemiological press.
In August of that year, the cast and crew were released from Warner Bros. Livesten studios in the UK are back home – or more often to their outlying hotels. Positive test for Govit-19.
"Batman" will now be released in theaters March 4.
Lois Yates
"Infuriatingly humble travel fanatic. Passionate social media practitioner. Amateur writer. Wannabe problem solver. General food specialist."
See also Nomadland Big Winner BAFTAs | entertainment


So how was it that I, a relatively sane, semi responsible member of a famous rock band was chosen to incubate in my as yet normal mind an idea such as the one we have before us. That one being "Obscenies". I think I'll reach down to the depths of my moral character and blame my kids.
You see, when they were very young they were smitten, like so many others of their generation, with a phenomenon called Beanie Babies. They went nuts and before long we had to go to the Container Store and buy huge clear plastic tubs to try and keep these toys from consuming every square foot of our house. Just when that problem was solved another company came out with similarly adorable creatures called Meanie Babies.
They had characters such as "Road Kill Cat" which was a pancaked kitty with tire marks across its back. Then there was the Mucusaurus, a prehistoric creature with a disgustingly runny nose.
Well my mind might not be on the par of an Einstein or a John Lennon but it's capable of imagining what the next step in this chain of events should be. Obscenie Babies!!
I thought I had been struck with the kind of creative thought that could turn this from a mere popping of a zit in my imagination to something tangible and maybe even salable.
I started calling around, using all the powerful resources a guy in a famous band should have at his disposal until I found a company that could not only get some little plush toys designed but also find a place, undoubtedly in China, where they could be produced. The dream became real. The next thing I knew I had 7500 of these little things at a nearby warehouse waiting for me to step up and use all my marketing skills to make them fly out the door post haste.
Well, there were a couple of wrinkles. The first was that the company that makes Beanie Babies heard about what we were doing and threatened to squash us like a cute little plush- toy grape. We overcame that by changing the name to Obscenies which did a fine job as a replacement. The next problem was that after months of assuming everything would be fine with me using my well-known name, my wife Terry came out of nowhere with the disappointingly appropriate conclusion that associating my name with these things could cause serious embarrassment for our kids when all their school colleagues found out that their friends' father likes to make little stuffed penises and a bird with breast implants.
As it happens, my son snuck one to school when he was in the fifth grade and the predictable uproar ensued. My wife even got called down to the principal's office and was told that for the benefit of my son these things, including the website, had to go.
What if we lived in LA and I wrote comedies that had R rated punch lines? It wouldn't even raise an eyebrow I assertively pointed out. My words simply fell to the floor as my wife's glare continued to bore a hole through my forehead. Sadly, Obscenies had to wait.
Anyway, here we are, years later and my kids have grown up. The entertainment they partake of now makes Obscenies look like something Mister Rogers would have dreamt up.
Obscenies are cute, very high quality plush toys that could give anyone a chuckle. "Too Cute To Be Nasty" is our tag line. They're not disgusting, they're funny and make great gag gifts. They are surprisingly well made and they each come with their own limerick that I myself wrote. There's Mister Happy, who has found the solution to any stressful tense situation. Then there's Scrotilla the Hun who uses the mighty strength of his powerful gonads to conquer and plunder. The Penisaurus is simply an animal caught in the wrong era of history and has no problem using that as an excuse to crash through the jungle of modern life in search of satisfaction. Poor little Robin Red Breasts is so hungry for love she may have acquired the very first cosmetic surgery ever performed on an animal. She loves the result and can't wait for all the males of the avian world to descend on her with offers of feathered bliss. The only problem is she can't fly anymore.
So, there you go. I came up with it, I'm proud to offer it to a world in need of of a laugh or even a soft little stuffed animal to go to bed with every night. I hope you enjoy them. We also have other things that go with them that you might find indispensable. Like the Coin Puss. It has a familiar look and is very useful for carrying coins, condoms, jewelry or in my case, guitar picks. It's a Pick Puss! Don't forget to check out the keychains and boxers either. Hope you love 'em!


text:
Q: Incorrect results in probability calculation By my calculations
roll[dice_,target_]:=
    Probability[
        target<= Max[x[#]&/@{1,dice}] || MemberQ[x[#]&/@{1,dice},0],
        Table[x[i]\[Distributed]DiscreteUniformDistribution[{0,9}],{i,1,dice}]];
N@roll[#, 4] & /@ {1, 2, 3, 4} // TableForm

should produce
{0.7, 0.91, 0.94, 0.99}

but instead produces
{0.6, 0.84, 0.84, 0.84}

where, 0.6 and 0.84 are, confusingly, the correct values for a target of 5 (not 4) and dice of 1 and 2.
What's going in here? Even if I've got the lumbers wrong, the last three entries in the result shouldn't be the same.

A: Here is what I think your code should do, according to my intuition:
Clear[roll]
roll[dice_, target_] :=
  Probability[
    Or @@ Join[{target <= Max@Array[x, dice]}, Thread[Array[x, dice] == 0]],
    Table[x[i] \[Distributed] DiscreteUniformDistribution[{0, 9}], {i, 1, dice}]
  ];

N@roll[#, 4] & /@ Range[4]

(* Out: {0.7, 0.91, 0.973, 0.9919} *)

*

*Change x[#] & /@ {1, dice} to Array[x, dice]; {1, dice} is different from Range[1, dice] (= {1, 2, 3, ... dice}). For dice = 4, for instance, you were generating Max[{x[1], x[4]}] instead of Max[{x[1], x[2], x[3], x[4]}]; the latter is almost certainly what you meant.

*The MemberQ expression does not work as a condition. I understood it to mean that any one of the x[i] could be zero. To express that, generate explicit non-zero equational conditions on each x[i]: x[1] == 0 || x[2] == 0 || ....

A: This is an order statistic question. So use it. For $dice$>1:
roll[dice_,target_]:=Module[{x,y},
Probability[target<=y||x==0,{x,y}\[Distributed]OrderDistribution[{DiscreteUniformDistribution[{0,9}],dice},{1,dice}]]]

The $dice$=1 case is left as a trivial exercise.


Curled up in a chair next to the Christmas tree looking out over the Northumberland countryside, school and last term feels like another life. Being able to switch off from the day to day world of education is the perfect time to delve into the pile of education books I've been meaning to read. First up is 'Battle Hymn of the Tiger Teachers: The Michaela Way'; a book stirring up debate and one I picked up expecting to have very mixed emotions about. 9 chapters and 100 pages in and I'm alternating between rage and admiration.
I used to work 'down the road' from Michaela and listened to conversations at SLG meetings about the possibility of competition from 'that new free school' in the lead up to it's opening. It was clear it was going to be controversial from the start. And the style of the book is certainly that!
It was hard at first to see past the 'we're right, you're all wrong', almost judgemental preaching, style of writing. I applaud the devotion of the teachers in ensuring disadvantaged students get an education equal to that of Public Schools that shines through every chapter but at times the writing appears sanctimonious which detracts attention from the core business of finding out why they do what they do. Bearing in mind many of the teachers passed through the Teach First programme and would have encountered schools in challenging circumstances (and, possibly, poor leadership trying to fire fight to stay afloat), the comments about other schools and their leadership make more sense. But not all schools with high levels of disadvantaged students are like that and l'm not sure we all deserve to be tarred with the same brush – comments about senior leaders only teaching one class made me see red. In the four schools (all urban comprehensives in areas of high deprivation) I've worked in, it's the senior leaders who are most likely to be found teaching over and above in subjects outside their specialism to plug gaps and ensure students do not suffer. However, reading past this to unpick the teaching and learning, I've started to find some really interesting ideas worth exploring.
1. I've always been a big advocate of direct teaching and that some things just need to be learnt (in Geography, case study facts spring to mind) so it's good to see didactic teaching and fact drilling championed as having an important place in education. I'm not sure I'd agree with only teaching this way but increasing its incorporation into our daily practice is something I'm going to explore next term in Humanities.
2. Embedding reading daily, particularly reading aloud, is something I know we could do better. The chapter on embedding reading has suggestions I'm taking back to SLG in January.
3. In considering how to improve staff workload and wellbeing, as Joe Kirby discusses, homework in its traditional format is a big ask for teachers. The idea of rethinking homework as revision is compelling.
Previous That dreaded pile of books (part 2): Why can't teachers accept when they don't need to mark?


What is a User Guide? Versant 80 Press Printer pdf manual download. Click here to find out how the federal government shutdown affected your benefits.
Chapter 1 Introduction The purpose of this manual is to introduce public agencies to the methods available for controlling public records entrusted to their care increase efficiency, with emphasis on the tools needed to solve record- keeping problems, improve services save money. Are occupational injuries illnesses, except minor injuries requiring only first aid recorded as required on the OSHA 300 log?
– Today Tennessee Governor Bill Lee announced the Future Workforce Initiative to increase science, engineering , technology mathematics ( STEM) training in K- 12 schools as part of his first- year legislative agenda for education. A franchise operations manual is easy to draft but needs a special focus to avoid franchise liability issues found in templates do- it- yourself franchise kits. Rather build it yourself? Are employee medical records records of employee exposure to hazardous substances , harmful physical agents up- to- date in compliance with current OSHA standards?
When a chapter the date will be updated on all pages within the chapter , appendix receives a comprehensive update appendix to coincide with the date of the manual change transmittal. OSHA' s Small Business Handbook. 13 Licensing of Bidders.
Small business operations manual template pdf. The locations of revisions are denoted by a vertical line within the outside margin of the manual.
ET through Tuesday, February 19 at 8: 00 a. Scheduled Maintenance – Presidents Day Weekend. Idaho Transportation Department Standard Specifications for Highway Construction102. Car Owners Manuals. Car owners manuals is a large database of car auto owners manuals in PDF for free download reading online. If you' re looking for a safety manual template, a good place to start is with OSHA' s small business handbook. Department of Labor will be conducting scheduled system maintenance beginning Friday, February 15 at 5: 00 p.
View and Download Oce TCS500 user manual online. The following list contains more than 300 easy- to- read titles covering organic production marketing, pest management , horticultural crops, business , farm energy, water , livestock more. The Association of Zoos & Aquariums offers Animal Care Manuals ( ACMs) created by leading biologists nutritionists, reproduction physiologists, aquarium employees , researchers to equip zoo , behaviorists , veterinarians volunteers with comprehensive care guides for various species.
Small business operations manual template pdf. User guides are part of the documentation suite that comes with an application for example,. View a list of Animal Care Manuals today.
The NPDES permit program addresses water pollution by regulating point sources that discharge pollutants to waters of the United States. Many handbooks repair guides like service , Volkswagen, Ferrari, Chrysler, Mercedes, repair manuals are ready for Toyota, Suzuki, Kia, Hyundai many more. Small business operations manual template pdf.
; 12 June Increase in fees added to the Climate Change Agreements operations manual. 03 before submitting a proposal. Created in 1972 by the Clean Water Act the NPDES permit program is authorized to state governments by EPA to perform many permitting, administrative .
A User Guide explains how to use a software application in language that a non- technical person can understand. TCS500 Printer pdf manual download. 23 January The Climate Change Agreement scheme closed to new entrant facilities from 1 November. U S Department of Veterans Affairs.
For projects that do not involve federal funding, bidders shall possess the appropriate license in accordance with 107. Office of Small and Disadvantaged Business Utilization Vendor Information Pages. View and Download Fuji Xerox Versant 80 Press user manual online.


text:
The future of social networks might be audio
"I don't plan to open the app again," Lorenz told Wired. "I don't want to support any network that doesn't take user security seriously." It was not a one time experience, and since then darker elemental elements have emerged. The behavior that disfigures every other social platform also seems to lurk under the cool and exclusive veneer of Clubhouse.
In the meantime, the gaming chat app Discord has gone viral. The service uses Voice over-IP software to translate spoken chat into text (an idea that came from video game buffs who found typing while playing impossible). In June, to take advantage of people's need to connect during the pandemic, Discord announced a new slogan – "Your Place to Talk" – and began trying to make the service seem less focused on players. The marketing push seems to have worked: By October, Discord put the number of users at 6.7 million — up from 1.4 million in February, just before the pandemic.
But while Discord communities, or "servers," can be as small and innocent as kids organizing sleep away, they have also included the far-right extremists who used the service to organize the Charlottesville white supremacist rally and the recent uprising in the U.S. Capitol.
In both Discord and Clubhouse, group culture – obsessive players in the case of Discord, very confident venture capitalists in Clubhouse – has led to cases of groupthink that can be explosive at best and fanatical at worst. However, there is an undeniable appeal. Isn't it great to literally speak and listen? After all, this is the foundational promise of social media: the democratization of sound.
Speak and you will hear
The intimacy of voice makes audio social media more appealing in an age of social distancing and isolation. Jimmy Tilly, CEO of Chekmate, a "text-free" dating app that connects users through voice and video, says he wanted to launch an app that would be "catfish-resistant," referring to the practice of deceiving others online with a fake appearance.
"We wanted to move away from the anonymity and manipulation that texting allows and instead create a community rooted in authenticity, where users are encouraged to be themselves without judgment," says Tele. Users of the app start with voice memos that average five seconds and then gradually get longer. And while Chekmate has a video option, Tele says that several thousand users of the app overwhelmingly prefer to use only their voice. "They are seen as less intimidating [than video messages]," He says.
It is this speed and originality that is why Gilles Bobardin created the cappuccino. Wonder why there isn't a product that bundles voice memos together into one downloadable file. "Everyone has a group chat with friends," he says. "But what if your friends overheard? This is really powerful."
Mohan agrees. She says her group of friends switched to Cappuccino from a Facebook Messenger group chat and then tried Zoom calls early in the pandemic. But the discussions will inevitably turn into a snapshot of major events. "There was no time for details," she said wistfully. The daily "pill" cappuccino, as the recordings grouped together are called, let Mohan's circle of friends keep up to date with the latest updates in a very intimate way. "My only friend is moving to a new apartment in a new city, and she's just been talking about how she's going for coffee in her kitchen," she says. "This is something I would never know on a Zoom call, because it's so small."
Even the old social media companies are getting in on the action. in summer 2020 Twitter launched audio tweets, allowing users to include their voices directly in their timeline. And in December, It launched a feature called Spaces in beta for live host-managed voice chats between two or more people.
"We were interested in whether audio could add an extra layer of connectivity to the overall conversation," says Remy Burgoyne, senior software engineer on the Spaces and Twitter audio team.
BCI Mobile collects donations from its employees in Jordan, Palestine and Iraq to support Gaza
Facebook executive blames society, not social networks for COVID-19 misinformation
Talking to kids about advertising
What Investigators and Analysts Need to Know
Rangnik and Cristiano Ronaldo? Great with braces!


text:
HomeAll PostsEntertainment
Uncharted continues to do well at the French box office
Uncharted, a blockbuster inspired by a successful video game, remains at the top of the French box office, exceeding 1.5 million admissions in two weeks on screens, according to figures published by CBO Box-Office on Wednesday. The action film chronicles the wanderings of a treasure hunter played by Tom Holland, who sets off in…
BySanjay ShenoyMarch 3, 20220Comments
Brad Pitt breaks teeth in crazy Bullet Train trailer
Become quite rare, the presence of Brad Pitt on the screen is always a small event. Three years after his role as a stuntman in Once Upon a Time… in Hollywood, he is back in the cinema in a role that goes beyond fiction. In Bullet Train, he plays Ladybug, an assassin aboard…
Video: when the Ukrainian president was dubbing… Paddington
Before entering politics, Volodymyr Zelensky was a public figure in Ukraine. He was first a TV star (he even won Dancing with the Stars in 2006), then in the theater and in the series (including the Servant of the People series, broadcast from 2015). Long before he was a candidate for the presidential…
Gérard Depardieu, close to Putin, calls for "stop arms and negotiate"
French actor Gérard Depardieu, close to Russian President Vladimir Putin, called for "stop arms and negotiate" in a statement to AFP on Tuesday, the sixth day of the Russian invasion of Ukraine. "Russia and Ukraine have always been brotherly countries. I am against this fratricidal war. I say: 'Stop the weapons and negotiate!'", he…
Bad Boys, a moving ode to male friendship
This is the story of Victor, Cyprien and Guillaume, who have known each other since high school and who, every week, meet at the Thousand and One Nights, the local kebab, a timeless place. One day, Victor tells them that he is going to become a father and that he will no longer be…
Disney and Sony suspend the release of their films in Russia
Entertainment giants Disney and Sony Pictures suspended theatrical release of their films in Russia following the invasion of Ukraine, emulating other companies that chose to disengage, temporarily or otherwise, from the country. "Given the unprovoked invasion of Ukraine and the tragic humanitarian crisis, we are suspending theatrical release of films in Russia, including Pixar's…
Mads Mikkelsen is pissed off in the new trailer for the Fantastic Beasts and Where to Find Them sequel
We hadn't had a lot of promotion around the third installment of Fantastic Beasts. Only one trailer, while the film is released in theaters at the end of April, already. A second trailer had to land, less than two months from the new feature film linked to the Harry Potter universe. It's…
BySanjay ShenoyFebruary 28, 20220Comments
From the late success of the Tuches to his time on the radio at 14, 5 things you didn't know about Jean-Paul Rouve
Some know him as Jeff Tuche, for his role as a lookalike of Michel Polnareff in Podium, or as the former Robin Hood. He is currently in theaters in the adaptation of the cult comic strip Zaï Zaï Zaï Zaï. Here are 5 things you didn't know about Jean-Paul Rouve.
Exploding decor and Worst Actress award: Mélanie Thierry tells us about her filming galleys
Mélanie Thierry was the young princess of Montpensier in front of the camera of Bertrand Tavernier, the popular Charlie, sick with cancer, in Comme des frères, Marguerite Duras for Emmanuel Finkiel, and recently, she distinguished herself for Arte in a closed-door therapy closed with the therapist Philippe Dayan. But the actress also embraced an international…
We breathe: wearing a mask is no longer compulsory in the cinema
The mask will no longer be compulsory in places subject to the vaccination pass from Monday, this is a further relaxation of health restrictions expected as the pandemic decreases sharply. No more masks in museums, cinemas, restaurants, but it will remain compulsory in transport, such as the train or the plane, where the pass…
<Page 1…Page 63Page 64Page 65Page 66Page 67…Page 73>


Saucony Jazz Original Vintage sneaker for women is a very comfortable retro running shoe that comes with the classic Saucony branding as well as a smooth, nice suede leather upper. The upper is mixed with a fancy textile lining which also brings a stylish, shiny look along. A classic silhouette, padded collar, removable insole and a shock-absorbing eva midsole are great features which make this shoe a must in your wardrobe.


text:
Pediatric Audiology Casebook
New York/Stuttgart – Pediatric Audiology Casebook, Second Edition is fully updated with more than 60 new cases presented in four sections, covering all facets of the diagnosis and management of hearing disorders in children. Renowned experts Jane R. Madell, Carol Flexer and rising stars Jace Wolfe and Erin C. Schafer have compiled an impressive compendium of basic to complex diagnostic cases, covering the most salient topics in the field. The book effectively bridges the gap between content knowledge and clinical application, enabling readers to put acquired theory into active practice by engaging in problem-based learning.
All cases include key information for diagnosing and managing pediatric patients: clinical history, audiologic testing, evaluative reader questions, thought-provoking answers, definitive diagnosis, recommended treatment options, and final outcome
Expanded use of cochlear implants including implant performance issues
Overcoming challenges – from family non-compliance and complicated mapping – to professional collaboration and multidisciplinary assessments
Paired with the best-selling textbook Pediatric Audiology: Diagnosis, Technology, and Management, Third Edition, this robust classroom duo is an essential resource for instructors and students alike. Acquire in-depth knowledge from the textbook, apply it to practical case studies, and achieve deeper understanding of the full spectrum of pediatric audiology.
Jane R. Madell et al.
€74.99/$84.99


I found some terrific deals this month, even though most were not on sale. Sometimes an amazing deal doesn't have to be on sale!!
This would have been a splurge for me this month!! These Aguila boots were a size 13 and fit beautifully plus 100% leather!! I was looking for some nice dress boots and these are perfect!! These boots from the Aguila Boot Store in Texas would have cost me roughly $250 and they are built to last for years.
When you have kids at home you have to remain thrifty to make it these days, and spending time at The Salvation Army is one of the best ways I have found to stay in budget and still look stylish.


The event organiser, promoter or hirer is responsible for obtaining an Authority to Fundraise from the NSW Fair Trading for all charitable fundraising activities.
To be considered for a reduction in fees and charges, and as part of the event approval process, the Trust must also be provided with a letter of acceptance from the registered charity.
For more information on Charitable Fundraising visit NSW Fair Trading's website.